NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2024405819|ref|XP_015132093|]
View 

protein FAM13A isoform X1 [Gallus gallus]

Protein Classification

Rho GTPase-activating protein( domain architecture ID 1569)

Rho GTPase-activating protein for Rho/Rac/Cdc42-like small GTPases that act as molecular switches, active in their GTP-bound form but inactive when bound to GDP

CATH:  1.10.555.10
Gene Ontology:  GO:0007165|GO:0005096
PubMed:  17222083|12480336
SCOP:  4001255

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
RhoGAP super family cl02570
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 70-258 1.60e-94

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


The actual alignment was detected with superfamily member cd04393:

Pssm-ID: 470621 [Multi-domain]  Cd Length: 189  Bit Score: 297.84  E-value: 1.60e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   70 KVFGVSLLELQQQGLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLK 149
Cdd:cd04393      1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  150 LFLRELPDGIITSALHSKFIQLYQDGRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFG 229
Cdd:cd04393     81 LFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFG 160

                          170       180
                   ....*....|....*....|....*....
gi 2024405819  230 PNCFHVPSGFEGIKEQEICNKIMTKMLES 258
Cdd:cd04393    161 PDVFHVYTDVEDMKEQEICSRIMAKLLEN 189
 
Name Accession Description Interval E-value
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 70-258 1.60e-94

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 297.84  E-value: 1.60e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   70 KVFGVSLLELQQQGLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLK 149
Cdd:cd04393      1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  150 LFLRELPDGIITSALHSKFIQLYQDGRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFG 229
Cdd:cd04393     81 LFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFG 160

                          170       180
                   ....*....|....*....|....*....
gi 2024405819  230 PNCFHVPSGFEGIKEQEICNKIMTKMLES 258
Cdd:cd04393    161 PDVFHVYTDVEDMKEQEICSRIMAKLLEN 189
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 89-259 2.63e-50

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 175.15  E-value: 2.63e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819    89 IPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEE-VELVKDGDVYSAASLLKLFLRELPDGIITSALHSK 167
Cdd:smart00324    3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEE 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   168 FIQLYQDGrNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPNCFHVPSGF-EGIKEQE 246
Cdd:smart00324   83 FIEAAKLE-DETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEvASLKDIR 161

                           170
                    ....*....|...
gi 2024405819   247 ICNKIMTKMLESY 259
Cdd:smart00324  162 HQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 90-237 3.92e-50

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 173.89  E-value: 3.92e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   90 PIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEV-ELVKDGDVYSAASLLKLFLRELPDGIITSALHSKF 168
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024405819  169 IQLYQDGrNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPNCFHVPS 237
Cdd:pfam00620   81 IEAAKLP-DEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
 
Name Accession Description Interval E-value
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 70-258 1.60e-94

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 297.84  E-value: 1.60e-94
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   70 KVFGVSLLELQQQGLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLK 149
Cdd:cd04393      1 KVFGVPLQELQQAGQPENGVPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  150 LFLRELPDGIITSALHSKFIQLYQDGRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFG 229
Cdd:cd04393     81 LFLQELPEGLIPASLQIRLMQLYQDYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENRMTAENLAAVFG 160

                          170       180
                   ....*....|....*....|....*....
gi 2024405819  230 PNCFHVPSGFEGIKEQEICNKIMTKMLES 258
Cdd:cd04393    161 PDVFHVYTDVEDMKEQEICSRIMAKLLEN 189
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 90-257 2.57e-51

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 177.88  E-value: 2.57e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   90 PIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLKLFLRELPDGIITSALHSKFI 169
Cdd:cd00159      1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  170 QLYQDGRNEVQKErNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPNCFHVPSGFEGIKEQ-EIC 248
Cdd:cd00159     81 ELAKIEDEEERIE-ALKELLKSLPPENRDLLKYLLKLLHKISQNSEVNKMTASNLAIVFAPTLLRPPDSDDELLEDiKKL 159


                   ....*....
gi 2024405819  249 NKIMTKMLE 257
Cdd:cd00159    160 NEIVEFLIE 168
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 89-259 2.63e-50

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 175.15  E-value: 2.63e-50
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819    89 IPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEE-VELVKDGDVYSAASLLKLFLRELPDGIITSALHSK 167
Cdd:smart00324    3 IPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELYEE 82

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   168 FIQLYQDGrNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPNCFHVPSGF-EGIKEQE 246
Cdd:smart00324   83 FIEAAKLE-DETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPDGEvASLKDIR 161

                           170
                    ....*....|...
gi 2024405819   247 ICNKIMTKMLESY 259
Cdd:smart00324  162 HQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 90-237 3.92e-50

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 173.89  E-value: 3.92e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   90 PIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEV-ELVKDGDVYSAASLLKLFLRELPDGIITSALHSKF 168
Cdd:pfam00620    1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVdLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2024405819  169 IQLYQDGrNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPNCFHVPS 237
Cdd:pfam00620   81 IEAAKLP-DEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 72-263 3.24e-38

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 141.32  E-value: 3.24e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQGLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLKLF 151
Cdd:cd04404      6 FGVSLQFLKEKNPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTF 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  152 LRELPDGIITSALHSKFIQLYQdgRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPN 231
Cdd:cd04404     86 LRELPEPLLTFDLYDDIVGFLN--VDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPN 163

                          170       180       190
                   ....*....|....*....|....*....|..
gi 2024405819  232 CFHVPSGFEGIKEQEICNKIMTKMLESYNTLF 263
Cdd:cd04404    164 LLWAKDASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 71-230 5.18e-34

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 129.02  E-value: 5.18e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   71 VFGVSL---LELQQQGLSKNGIPIVVWNIVEYL-TQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDG---DVYS 143
Cdd:cd04400      1 IFGSPLeeaVELSSHKYNGRDLPSVVYRCIEYLdKNRAIYEEGIFRLSGSASVIKQLKERFNTEYDVDLFSSSlypDVHT 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  144 AASLLKLFLRELPDGIITSALHSKFIQLYQDGRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCN 223
Cdd:cd04400     81 VAGLLKLYLRELPTLILGGELHNDFKRLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRN 160


                   ....*..
gi 2024405819  224 LATVFGP 230
Cdd:cd04400    161 VCIVFSP 167
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 79-259 6.55e-33

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 125.88  E-value: 6.55e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   79 LQQQGLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGE-EVELVKDGD-VYSAASLLKLFLRELP 156
Cdd:cd04385      5 LEDQQLTDNDIPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKDArSVQLREGEYtVHDVADVLKRFLRDLP 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  157 DGIITSALHSKFIQlYQDGRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPNCFHVP 236
Cdd:cd04385     85 DPLLTSELHAEWIE-AAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNLALVFGPTLFQTD 163

                          170       180
                   ....*....|....*....|...
gi 2024405819  237 SGFEGIKEQEIcnKIMTKMLESY 259
Cdd:cd04385    164 EHSVGQTSHEV--KVIEDLIDNY 184
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 71-233 4.68e-30

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 118.31  E-value: 4.68e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   71 VFGVSLLE--LQQQGLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLL 148
Cdd:cd04390      2 VFGQRLEDtvAYERKFGPRLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLL 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  149 KLFLRELPDGIITSALHSKFIQLYQD-GRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATV 227
Cdd:cd04390     82 KLYLRELPEPVIPWAQYEDFLSCAQLlSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSVNKMSVQNLATV 161


                   ....*.
gi 2024405819  228 FGPNCF 233
Cdd:cd04390    162 FGPNIL 167
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 72-263 4.95e-30

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 117.89  E-value: 4.95e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLEL-QQQGLSkngIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVEL-----VKDGDVYSAA 145
Cdd:cd04398      1 FGVPLEDLiLREGDN---VPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLlispeDYESDIHSVA 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  146 SLLKLFLRELPDGIITSALHSKFIQLYQDgRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLA 225
Cdd:cd04398     78 SLLKLFFRELPEPLLTKALSREFIEAAKI-EDESRRRDALHGLINDLPDANYATLRALMFHLARIKEHESVNRMSVNNLA 156

                          170       180       190
                   ....*....|....*....|....*....|....*...
gi 2024405819  226 TVFGPNCFHVPSgfEGIKEQEICNKIMTKMLESYNTLF 263
Cdd:cd04398    157 IIWGPTLMNAAP--DNAADMSFQSRVIETLLDNAYQIF 192
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 71-242 3.35e-28

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 112.95  E-value: 3.35e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   71 VFGVSLLELQQQGLSKNG-IPIVVWNIVEYLTQHGMTqEGLFRVNGSMKTVEQLRLQYERGEEV-ELVKDGDVysaASLL 148
Cdd:cd04394      1 VFGVPLHSLPHSTVPEYGnVPKFLVDACTFLLDHLST-EGLFRKSGSVVRQKELKAKLEGGEAClSSALPCDV---AGLL 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  149 KLFLRELPDGIITSALHSKFIQLYQDGRNEVQKERN-LKELLkeLPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATV 227
Cdd:cd04394     77 KQFFRELPEPLLPYDLHEALLKAQELPTDEERKSATlLLTCL--LPDEHVNTLRYFFSFLYDVAQRCSENKMDSSNLAVI 154

                          170
                   ....*....|....*
gi 2024405819  228 FGPNCFHVPSGFEGI 242
Cdd:cd04394    155 FAPNLFQSEEGGEKM 169
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 89-263 1.56e-26

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 108.30  E-value: 1.56e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   89 IPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLKLFLRELPDGIITSALHSKF 168
Cdd:cd04376      9 VPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLLPRELYTAF 88

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  169 IQLyQDGRNEVQKErNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVE-----------NRMNLCNLATVFGPNCFHVPS 237
Cdd:cd04376     89 IGT-ALLEPDEQLE-ALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADsidedgqevsgNKMTSLNLATIFGPNLLHKQK 166

                          170       180       190
                   ....*....|....*....|....*....|....
gi 2024405819  238 GFE--------GIKEQEICNKIMTKMLESYNTLF 263
Cdd:cd04376    167 SGErefvqaslRIEESTAIINVVQTMIDNYEELF 200
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 89-236 2.00e-26

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 107.60  E-value: 2.00e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   89 IPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYER-GEEVELVKD--GDVYSAASLLKLFLRELPDGIITSALH 165
Cdd:cd04372     16 RPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRdGEKADISATvyPDINVITGALKLYFRDLPIPVITYDTY 95

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024405819  166 SKFIQLYQDGRNEVQKErNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPNCFHVP 236
Cdd:cd04372     96 PKFIDAAKISNPDERLE-AVHEALMLLPPAHYETLRYLMEHLKRVTLHEKDNKMNAENLGIVFGPTLMRPP 165
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 71-231 3.63e-26

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 107.16  E-value: 3.63e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   71 VFGVSLlelqQQGLSKNG--IPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKD--GDVYSAAS 146
Cdd:cd04386      4 VFGTPL----EEHLKRTGreIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGTFSLPLDEfySDPHAVAS 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  147 LLKLFLRELPDGIITSALHSKFIQLYQDgRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLAT 226
Cdd:cd04386     80 ALKSYLRELPDPLLTYNLYEDWVQAANK-PDEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAI 158


                   ....*
gi 2024405819  227 VFGPN 231
Cdd:cd04386    159 VLAPN 163
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 71-263 1.56e-25

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 105.51  E-value: 1.56e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   71 VFGVS---LLELQQQGLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYER--GEEVELVKDGDVYSAA 145
Cdd:cd04391      1 LFGVPlstLLERDQKKVPGSKVPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAkfYEGTFLWDQVKQHDAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  146 SLLKLFLRELPDGIITSALHSKFIQLyQDGRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLA 225
Cdd:cd04391     81 SLLKLFIRELPQPLLTVEYLPAFYSV-QGLPSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEKNKMNLWNVA 159

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*.
gi 2024405819  226 TVFGPNCF--------HVPSGFEGIKEQEICNKIMTKMLESYNTLF 263
Cdd:cd04391    160 MIMAPNLFpprgkhskDNESLQEEVNMAAGCANIMRLLIRYQDLLW 205
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 72-230 2.27e-25

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 104.05  E-value: 2.27e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQGLSKNGI--PIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELvKDGDVYSAASLLK 149
Cdd:cd04381      1 FGASLSLAVERSRCHDGIdlPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNL-EEYEPPTVASLLK 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  150 LFLRELPDGIITSALHSKFIQLYqdGR-NEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVF 228
Cdd:cd04381     80 QYLRELPEPLLTKELMPRFEEAC--GRpTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISIVL 157


                   ..
gi 2024405819  229 GP 230
Cdd:cd04381    158 SP 159
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 70-252 3.03e-25

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 104.04  E-value: 3.03e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   70 KVFGVSLLELQQQglSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEE--VELVKDGDVYSAASL 147
Cdd:cd04383      1 KLFNGSLEEYIQD--SGQAIPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGEDplADDQNDHDINSVAGV 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  148 LKLFLRELPDGIITSALHSKFIQLYQDgRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATV 227
Cdd:cd04383     79 LKLYFRGLENPLFPKERFEDLMSCVKL-ENPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENMMDPYNLAIC 157

                          170       180
                   ....*....|....*....|....*
gi 2024405819  228 FGPNCFHVPSGFEGIKEQEICNKIM 252
Cdd:cd04383    158 FGPTLMPVPEGQDQVSCQAHVNELI 182
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 72-234 4.56e-25

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 103.24  E-value: 4.56e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQglSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVEL--VKDGDVYSAASLLK 149
Cdd:cd04403      1 FGCHLEALCQR--ENSTVPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRFAVDHDEKLDLddSKWEDIHVITGALK 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  150 LFLRELPDGIITSALHSKFIQLYQDgRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFG 229
Cdd:cd04403     79 LFFRELPEPLFPYSLFNDFVAAIKL-SDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEKNRMTTQNLAIVFG 157


                   ....*
gi 2024405819  230 PNCFH 234
Cdd:cd04403    158 PTLLR 162
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 89-257 3.00e-24

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 101.22  E-value: 3.00e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   89 IPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLKLFLRELPDGIITSALHSKF 168
Cdd:cd04382     17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKEF 96

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  169 IQLYQdGRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHvENRMNLCNLATVFGPNCF-HV---PSGFEGIKE 244
Cdd:cd04382     97 MEAAE-ILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQSP-ECKMDINNLARVFGPTIVgYSvpnPDPMTILQD 174

                          170
                   ....*....|...
gi 2024405819  245 QEICNKIMTKMLE 257
Cdd:cd04382    175 TVRQPRVVERLLE 187
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 72-230 7.43e-24

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 100.57  E-value: 7.43e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQglSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEE-VELvKDGDVYSAASLLKL 150
Cdd:cd04378      1 FGVDFSQVPRD--FPDEVPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDlVEL-SELSPHDISSVLKL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  151 FLRELPDGIITSALHSKFIQLYQDGR--NEVQKE-----------RNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVEN 217
Cdd:cd04378     78 FLRQLPEPLILFRLYNDFIALAKEIQrdTEEDKApntpievnriiRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEEN 157

                          170
                   ....*....|...
gi 2024405819  218 RMNLCNLATVFGP 230
Cdd:cd04378    158 KMSPNNLGIVFGP 170
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 70-265 3.92e-23

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 99.03  E-value: 3.92e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   70 KVFGVSL-LELQQQGLSkngIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLL 148
Cdd:cd04375      3 NVFGVPLlVNLQRTGQP---LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADML 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  149 KLFLRELPDGIITSALHSKFIQLYQDGRNEVQKERNLKELLKeLPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVF 228
Cdd:cd04375     80 KQYFRDLPEPLLTNKLSETFIAIFQYVPKEQRLEAVQCAILL-LPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCL 158

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024405819  229 GPNCFHV----------------------PSGFEgIKEQEICNKIMTKMLESYNTLFEL 265
Cdd:cd04375    159 APSLFHLntsrrenssparrmqrkkslgkPDQKE-LSENKAAHQCLAYMIEECNTLFMV 216
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 70-236 4.53e-23

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 97.96  E-value: 4.53e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   70 KVFGVSLLELQQQglSKNGIPIVVWNIVEYLTQHGMTqEGLFRVNGSMKTVEQLRLQYERGEEVELVKDG---DVYSAAS 146
Cdd:cd04384      1 RVFGCDLTEHLLN--SGQDVPQVLKSCTEFIEKHGIV-DGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVyiqDIHSVSS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  147 LLKLFLRELPDGIITSALHSKFIQLYQDGRNEVQKERnLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLAT 226
Cdd:cd04384     78 LCKLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEK-IHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNLAI 156

                          170
                   ....*....|
gi 2024405819  227 VFGPNCFHVP 236
Cdd:cd04384    157 VWAPNLLRSK 166
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 72-233 5.21e-23

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 97.53  E-value: 5.21e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQqqgLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELV-KDGDVYSAASLLKL 150
Cdd:cd04373      1 FGVPLANVV---TSEKPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVsKDFTVNAVAGALKS 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  151 FLRELPDGIITSALHSKFIQLYQDGRNEvQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGP 230
Cdd:cd04373     78 FFSELPDPLIPYSMHLELVEAAKINDRE-QRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNLMTSENLSICFWP 156


                   ...
gi 2024405819  231 NCF 233
Cdd:cd04373    157 TLM 159
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 71-231 9.32e-23

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 97.09  E-value: 9.32e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   71 VFGVSLlELQQQGLSKNGIPIVV---WNIVEyltQHGMTQEGLFRVNGSMKTVEQLRLQYERG-EEVELVKD--GDVYSA 144
Cdd:cd04395      1 TFGVPL-DDCPPSSENPYVPLIVevcCNIVE---ARGLETVGIYRVPGNNAAISALQEELNRGgFDIDLQDPrwRDVNVV 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  145 ASLLKLFLRELPDGIITSALHSKFIQLyqdGRNEVQKER--NLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLC 222
Cdd:cd04395     77 SSLLKSFFRKLPEPLFTNELYPDFIEA---NRIEDPVERlkELRRLIHSLPDHHYETLKHLIRHLKTVADNSEVNKMEPR 153


                   ....*....
gi 2024405819  223 NLATVFGPN 231
Cdd:cd04395    154 NLAIVFGPT 162
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 72-244 3.57e-22

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 95.06  E-value: 3.57e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELqqqgLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELvKDGDVYSAASLLKLF 151
Cdd:cd04402      2 FGQPLSNI----CEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDL-KAEPVLLLASVLKDF 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  152 LRELPDGIITSALHSKFIQLYQDGRNEvQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPN 231
Cdd:cd04402     77 LRNIPGSLLSSDLYEEWMSALDQENEE-EKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPS 155

                          170
                   ....*....|...
gi 2024405819  232 CFHVPSGFEGIKE 244
Cdd:cd04402    156 LLWPPASSELQNE 168
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 72-230 2.62e-21

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 92.50  E-value: 2.62e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQglsKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLKLF 151
Cdd:cd04377      1 FGVSLSSLTSE---DRSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHVITSVLKQW 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  152 LRELPDGIITSALHSKFIQL--YQDGRNEVqkeRNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFG 229
Cdd:cd04377     78 LRELPEPLMTFELYENFLRAmeLEEKQERV---RALYSVLEQLPRANLNTLERLIFHLVRVALQEEVNRMSANALAIVFA 154


                   .
gi 2024405819  230 P 230
Cdd:cd04377    155 P 155
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 72-230 7.39e-21

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 91.53  E-value: 7.39e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQGLSKngIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERG--EEVELVKDGDVYSAASLLK 149
Cdd:cd04387      1 FGVKISTVTKRERSK--VPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNnkDVSVMLSEMDVNAIAGTLK 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  150 LFLRELPDGIITSALHSKFIQLYqDGRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFG 229
Cdd:cd04387     79 LYFRELPEPLFTDELYPNFAEGI-ALSDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVAEREEVNKMSLHNLATVFG 157


                   .
gi 2024405819  230 P 230
Cdd:cd04387    158 P 158
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 72-238 1.14e-20

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 91.03  E-value: 1.14e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQglSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLKLF 151
Cdd:cd04408      1 FGVDFSQLPRD--FPEEVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHF 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  152 LRELPDGIITSALHSKFIQL---YQDGRNEVQKE--------RNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMN 220
Cdd:cd04408     79 LKELPEPVLPFQLYDDFIALakeLQRDSEKAAESpsiveniiRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMS 158

                          170
                   ....*....|....*...
gi 2024405819  221 LCNLATVFGPNCFHVPSG 238
Cdd:cd04408    159 PNNLGIVFGPTLLRPLVG 176
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 72-232 1.31e-19

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 87.83  E-value: 1.31e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLEL---QQQGLSKNGIPIVVWNIVEYLTQHGMTQ-EGLFRVNGSMKTVEQLRLQYERGEeVELVKDGDVYSAASL 147
Cdd:cd04389      1 FGSSLEEImdrQKEKYPELKLPWILTFLSEKVLALGGFQtEGIFRVPGDIDEVNELKLRVDQWD-YPLSGLEDPHVPASL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  148 LKLFLRELPDGIITSAlhskfiqLYQDGRNEVQKERNLKELLKELPDAHYCLLKYLCQFL-IKVAEHHVE-NRMNLCNLA 225
Cdd:cd04389     80 LKLWLRELEEPLIPDA-------LYQQCISASEDPDKAVEIVQKLPIINRLVLCYLINFLqVFAQPENVAhTKMDVSNLA 152


                   ....*..
gi 2024405819  226 TVFGPNC 232
Cdd:cd04389    153 MVFAPNI 159
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 72-236 7.64e-19

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 85.43  E-value: 7.64e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQglsKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLKLF 151
Cdd:cd04407      1 FGVRVGSLTSN---KTSVPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLENYPIHAITGLLKQW 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  152 LRELPDGIITSALHSKFiqLYQDGRNEVQKE-RNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGP 230
Cdd:cd04407     78 LRELPEPLMTFAQYNDF--LRAVELPEKQEQlQAIYRVLEQLPTANHNTLERLIFHLVKVALEEDVNRMSPNALAIVFAP 155


                   ....*.
gi 2024405819  231 NCFHVP 236
Cdd:cd04407    156 CLLRCP 161
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 72-230 3.16e-18

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 84.47  E-value: 3.16e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQglSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLKLF 151
Cdd:cd04409      1 FGADFAQVAKK--SPDGIPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLY 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  152 LRELPDGIITSALHSKFIQLY---------QDGRNEVQKER------------NLKELLKELPDAHYCLLKYLCQFLIKV 210
Cdd:cd04409     79 LRQLPEPLILFRLYNEFIGLAkesqhvnetQEAKKNSDKKWpnmctelnrillKSKDLLRQLPAPNYNTLQFLIVHLHRV 158

                          170       180
                   ....*....|....*....|
gi 2024405819  211 AEHHVENRMNLCNLATVFGP 230
Cdd:cd04409    159 SEQAEENKMSASNLGIIFGP 178
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 72-231 4.93e-18

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 83.95  E-value: 4.93e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQ---------GLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERG--EEVELVKDGD 140
Cdd:cd04397      1 FGVPLEILVEKfgadstlgvGPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNptEVPDLSKENP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  141 VYSAAsLLKLFLRELPDGIITSALHSKFIQlYQDGRNEVQKERNLKELLKELPDAHYCLLKYLCQFLIKVAE-HHVE--- 216
Cdd:cd04397     81 VQLAA-LLKKFLRELPDPLLTFKLYRLWIS-SQKIEDEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSfSHIDeet 158

                          170
                   ....*....|....*.
gi 2024405819  217 -NRMNLCNLATVFGPN 231
Cdd:cd04397    159 gSKMDIHNLATVITPN 174
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 93-230 1.48e-16

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 79.43  E-value: 1.48e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   93 VWNIVEYLTQHgMTQEGLFRVNGSMKTVEQLRLQYERGEEVELvkDGDVYSA---ASLLKLFLRELPDGIITSA---LHS 166
Cdd:cd04392     13 IYQLIEYLEKN-LRVEGLFRKPGNSARQQELRDLLNSGTDLDL--ESGGFHAhdcATVLKGFLGELPEPLLTHAhypAHL 89

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2024405819  167 KFIQLYQ--DGRNE---VQKER---NLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGP 230
Cdd:cd04392     90 QIADLCQfdEKGNKtsaPDKERlleALQLLLLLLPEENRNLLKLILDLLYQTAKHEDKNKMSADNLALLFTP 161
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 71-237 4.02e-16

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 78.61  E-value: 4.02e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   71 VFGVSLLELQQQG------LSKNG-------IPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVK 137
Cdd:cd04396      1 VFGVSLEESLKYAsvaisiVDEDGeqyvygyIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDYGKSF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  138 DGDVYS---AASLLKLFLRELPDGIITSALHSKF---------IQLYQDGRNEVQKERNL-------KELLKELPDAHYC 198
Cdd:cd04396     81 DWDGYTvhdAASVLRRYLNNLPEPLVPLDLYEEFrnplrkrprILQYMKGRINEPLNTDIdqaikeyRDLITRLPNLNRQ 160

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2024405819  199 LLKYLCQFLIKVAEHHVENRMNLCNLATVFGPNCFHVPS 237
Cdd:cd04396    161 LLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPD 199
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 72-230 4.31e-15

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 75.20  E-value: 4.31e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQGLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEE-VELVKDG--DVYSAASLL 148
Cdd:cd04379      1 FGVPLSRLVEREGESRDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNSAaVELSEELypDINVITGVL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  149 KLFLRELPDGIITSALHSKFIQ-LYQDGRNEVQKERNL-KELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLAT 226
Cdd:cd04379     81 KDYLRELPEPLITPQLYEMVLEaLAVALPNDVQTNTHLtLSIIDCLPLSAKATLLLLLDHLSLVLSNSERNKMTPQNLAV 160


                   ....
gi 2024405819  227 VFGP 230
Cdd:cd04379    161 CFGP 164
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 89-230 5.35e-15

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 75.07  E-value: 5.35e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   89 IPIVVWNIVEYLTQHGMTQEGLFrvngsmktvEQLRLQYERGEEVELVKD-----------GDVYSAASLLKLFLRELPD 157
Cdd:cd04380     50 IPKEIWRLVDYLYTRGLAQEGLF---------EEPGLPSEPGELLAEIRDaldtgspfnspGSAESVAEALLLFLESLPD 120

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024405819  158 GIITSALHSKFIQLYQDgrnevqKERNLKELLKE-LPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGP 230
Cdd:cd04380    121 PIIPYSLYERLLEAVAN------NEEDKRQVIRIsLPPVHRNVFVYLCSFLRELLSESADRGLDENTLATIFGR 188
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 72-236 9.22e-14

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 70.80  E-value: 9.22e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLLELQQQglsKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEQLRLQYERGEEVELVKDGDVYSAASLLKLF 151
Cdd:cd04406      1 FGVELSRLTSE---DRSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQW 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  152 LRELPDGIITSALHSKFIQLY--QDGRNEVqkeRNLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFG 229
Cdd:cd04406     78 LRDLPNPLMTFELYEEFLRAMglQERRETV---RGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFA 154


                   ....*..
gi 2024405819  230 PNCFHVP 236
Cdd:cd04406    155 PCILRCP 161
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 84-230 3.77e-13

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 69.34  E-value: 3.77e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   84 LSKNGIPIVVwNIVEYLTQHGMTQEGLFRVNGSMKTVEQLR---LQYERGEEVEL---VKDGDVYSAASLLKLFLRELPD 157
Cdd:cd04374     24 LDDIGFKFVR-KCIEAVETRGINEQGLYRVVGVNSKVQKLLslgLDPKTSTPGDVdldNSEWEIKTITSALKTYLRNLPE 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2024405819  158 GIITSALHSKFIQLyqdGRNEVQKER--NLKELLKELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGP 230
Cdd:cd04374    103 PLMTYELHNDFINA---AKSENLESRvnAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKKNLMTVSNLGVVFGP 174
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 75-258 8.43e-06

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 47.95  E-value: 8.43e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   75 SLLELQQQGLSKNGIPIVVWNIVEYLTQHGMTQEGLFRVNGSMKTVEqLRLQYERGEEVELVKDGDVYSAASLLKLFLRE 154
Cdd:cd04388      1 TLPDLTEQFSPPDVAPPLLIKLVEAIEKKGLESSTLYRTQSSSSLTE-LRQILDCDAASVDLEQFDVAALADALKRYLLD 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  155 LPDGIITSALHSKFIQLYQDGRNEVQKERNLKELLK--ELPDAHYCLLKYLCQFLIKVAEHHVENRMNLCNLATVFGPNC 232
Cdd:cd04388     80 LPNPVIPAPVYSEMISRAQEVQSSDEYAQLLRKLIRspNLPHQYWLTLQYLLKHFFRLCQSSSKNLLSARALAEIFSPLL 159

                          170       180
                   ....*....|....*....|....*.
gi 2024405819  233 FHVPSGFEGIKEQEIcnKIMTKMLES 258
Cdd:cd04388    160 FRFQPASSDSPEFHI--RIIEVLITS 183
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 72-196 6.95e-05

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 45.02  E-value: 6.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819   72 FGVSLlELQQqGLSKNGIPIVVWNIVEYLTQHGMTQEG------LFRVNGSMKTVEQLRLQYERG----EEVELVKDGDV 141
Cdd:cd04399      1 FGVDL-ETRC-RLDKKVVPLIVSAILSYLDQLYPDLINdevrrnVWTDPVSLKETHQLRNLLNKPkkpdKEVIILKKFEP 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  142 YSAASLLKLFLRELPDGIITSALHSKFIQLYQ-----DGRNEVQKERNLKELLKELPDAH 196
Cdd:cd04399     79 STVASVLKLYLLELPDSLIPHDIYDLIRSLYSayppsQEDSDTARIQGLQSTLSQLPKSH 138
RhoGAP_fMSB1 cd04401
RhoGAP_fMSB1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 129-263 3.87e-03

RhoGAP_fMSB1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal MSB1-like proteins. Msb1 was originally identified as a multicopy suppressor of temperature sensitive cdc42 mutation. Msb1 is a positive regulator of the Pkc1p-MAPK pathway and 1,3-beta-glucan synthesis, both pathways involve Rho1 regulation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239866  Cd Length: 198  Bit Score: 39.64  E-value: 3.87e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024405819  129 RGEEVELVKDGDVYSAASLLKLFLRELPDGIITSalhskfIQLYQDGRnevQKERNLK-------ELLKEL--PDAHYCL 199
Cdd:cd04401     58 TAELLDELRYADPHTLILVLKWIWSRLPGSKVIW------WEVYEEFK---ARERRSNypadaflDLLPQClsSPAHASI 128

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2024405819  200 LKYLCQFLIKVAEHHVENRMNLCNLATVFGPNCFHVPSGFEGIKEQEICNKIMTKMLESYNTLF 263
Cdd:cd04401    129 LYDFFDLLSSIAAHSSVNGMSGRKLSKMAGPWAFGKPTGATGPPSFQEGLDAWVRAANATEHLF 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH