phosphatidylcholine:ceramide cholinephosphotransferase 1 isoform X1 [Gallus gallus]
Protein Classification
sphingomyelin synthase family protein; SAM domain-containing protein( domain architecture ID 10175736)
sphingomyelin synthase family protein belonging to the type 2 phosphatidic acid phosphatase (PAP2) superfamily, similar to phosphatidylinositol:ceramide inositolphosphotransferase that is capable of converting phosphatidylinositol (PI) and ceramide to inositol-phosphorylceramide (IPC) and diacylglycerol (DAG) and vice versa| SAM (sterile alpha motif) domain-containing protein may be involved in protein-protein interaction and in developmental regulation; similar to Drosophila melanogaster protein matrimony, a polo kinase inhibitor required to maintain G2 arrest in the meiotic cell cycle in females
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| SAM_SGMS1 | cd09514 | SAM domain of sphingomyelin synthase; SAM (sterile alpha motif) domain of SGMS-1 ... |
1-72 | 1.46e-44 | ||
SAM domain of sphingomyelin synthase; SAM (sterile alpha motif) domain of SGMS-1 (sphingomyelin synthase) subfamily is a potential protein-protein interaction domain. Sphingomyelin synthase 1 is a transmembrane protein with a SAM domain at the N-terminus and a catalytic domain at the C-terminus. Sphingomyelin synthase 1 is a Golgi-associated enzyme, and depending on the concentration of diacylglycerol and ceramide, can catalyze synthesis phosphocholine or sphingomyelin, respectively. It plays a central role in sphingolipid and glycerophospholipid metabolism. : Pssm-ID: 188913 Cd Length: 72 Bit Score: 149.17 E-value: 1.46e-44
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| PAP2_C | pfam14360 | PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2. |
276-349 | 5.84e-33 | ||
PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2. : Pssm-ID: 464150 Cd Length: 74 Bit Score: 118.47 E-value: 5.84e-33
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| Name | Accession | Description | Interval | E-value | ||
| SAM_SGMS1 | cd09514 | SAM domain of sphingomyelin synthase; SAM (sterile alpha motif) domain of SGMS-1 ... |
1-72 | 1.46e-44 | ||
SAM domain of sphingomyelin synthase; SAM (sterile alpha motif) domain of SGMS-1 (sphingomyelin synthase) subfamily is a potential protein-protein interaction domain. Sphingomyelin synthase 1 is a transmembrane protein with a SAM domain at the N-terminus and a catalytic domain at the C-terminus. Sphingomyelin synthase 1 is a Golgi-associated enzyme, and depending on the concentration of diacylglycerol and ceramide, can catalyze synthesis phosphocholine or sphingomyelin, respectively. It plays a central role in sphingolipid and glycerophospholipid metabolism. Pssm-ID: 188913 Cd Length: 72 Bit Score: 149.17 E-value: 1.46e-44
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| PAP2_C | pfam14360 | PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2. |
276-349 | 5.84e-33 | ||
PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2. Pssm-ID: 464150 Cd Length: 74 Bit Score: 118.47 E-value: 5.84e-33
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| SAM_3 | pfam18016 | SAM domain (Sterile alpha motif); |
8-46 | 8.28e-05 | ||
SAM domain (Sterile alpha motif); Pssm-ID: 436214 Cd Length: 65 Bit Score: 40.33 E-value: 8.28e-05
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| SAM | smart00454 | Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ... |
4-68 | 8.69e-04 | ||
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation. Pssm-ID: 197735 Cd Length: 68 Bit Score: 37.66 E-value: 8.69e-04
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| PAP2_like | cd01610 | PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ... |
283-348 | 3.39e-03 | ||
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins. Pssm-ID: 238813 [Multi-domain] Cd Length: 122 Bit Score: 37.44 E-value: 3.39e-03
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| acidPPc | smart00014 | Acid phosphatase homologues; |
283-339 | 9.83e-03 | ||
Acid phosphatase homologues; Pssm-ID: 214471 [Multi-domain] Cd Length: 116 Bit Score: 35.78 E-value: 9.83e-03
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| Name | Accession | Description | Interval | E-value | ||
| SAM_SGMS1 | cd09514 | SAM domain of sphingomyelin synthase; SAM (sterile alpha motif) domain of SGMS-1 ... |
1-72 | 1.46e-44 | ||
SAM domain of sphingomyelin synthase; SAM (sterile alpha motif) domain of SGMS-1 (sphingomyelin synthase) subfamily is a potential protein-protein interaction domain. Sphingomyelin synthase 1 is a transmembrane protein with a SAM domain at the N-terminus and a catalytic domain at the C-terminus. Sphingomyelin synthase 1 is a Golgi-associated enzyme, and depending on the concentration of diacylglycerol and ceramide, can catalyze synthesis phosphocholine or sphingomyelin, respectively. It plays a central role in sphingolipid and glycerophospholipid metabolism. Pssm-ID: 188913 Cd Length: 72 Bit Score: 149.17 E-value: 1.46e-44
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| PAP2_C | pfam14360 | PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2. |
276-349 | 5.84e-33 | ||
PAP2 superfamily C-terminal; This family is closely related to the C-terminal a region of PAP2. Pssm-ID: 464150 Cd Length: 74 Bit Score: 118.47 E-value: 5.84e-33
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| SAM_CP2-like | cd09537 | SAM domain of CP2-like transcription factors; SAM (sterile alpha motif) domain of CP2-like ... |
8-44 | 1.26e-05 | ||
SAM domain of CP2-like transcription factors; SAM (sterile alpha motif) domain of CP2-like transcription factor is a putative protein-protein interaction domain. Proteins of this group have an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and some also have a C-terminal dimerization domain. CP2-like family of transcriptional factors includes three subgroups: LBP1, TFCP2, and LBP9. Members of this family are involved in transcriptional regulation from early development to terminal differentiation. They play a role in regulation of expression of P450scc (the cholesterol side-chain cleavage enzyme, cytochrome) in placenta, and alpha-globin in erythroid cells. They are required for proper maturation of the dust (epithelial component of tubular organs) of kidney and salivary gland. Human LBP1 is known to be induced by HIV type I infection in lymphocytes; it represses HIV transcription by preventing the binding of TFIID to the virus promoter. Additionally, it has been suggested that UBP1 (LBP1) regulator might be a member of a blood pressure controlling network. LBP1 protein isoforms are able to form dimers apparently via SAM domain since SAM deletion or mutation resulted in a loss of this ability. Pssm-ID: 188936 Cd Length: 67 Bit Score: 42.73 E-value: 1.26e-05
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| SAM_3 | pfam18016 | SAM domain (Sterile alpha motif); |
8-46 | 8.28e-05 | ||
SAM domain (Sterile alpha motif); Pssm-ID: 436214 Cd Length: 65 Bit Score: 40.33 E-value: 8.28e-05
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| SAM_WDSUB1 | cd09505 | SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins ... |
4-69 | 1.11e-04 | ||
SAM domain of WDSUB1 proteins; SAM (sterile alpha motif) domain of WDSUB1 subfamily proteins is a putative protein-protein interaction domain. Proteins of this group contain multiple domains: SAM, one or more WD40 repeats and U-box (derived version of the RING-finger domain). Apparently the WDSUB1 subfamily proteins participate in protein degradation through ubiquitination, since U-box domain are known as a member of E3 ubiquitin ligase family, while SAM and WD40 domains most probably are responsible for an E2 ubiquitin-conjugating enzyme binding and a target protein binding. Pssm-ID: 188904 Cd Length: 72 Bit Score: 40.38 E-value: 1.11e-04
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| SAM_SGMS1-like | cd09515 | SAM domain of sphingomyelin synthase related subfamily; SAM (sterile alpha motif) domain of ... |
4-50 | 2.20e-04 | ||
SAM domain of sphingomyelin synthase related subfamily; SAM (sterile alpha motif) domain of SGMS-like (sphingomyelin synthase) subfamily is a potential protein-protein interaction domain. This group of proteins is related to sphingomyelin synthase 1, and contains an N-terminal SAM domain. The function of SGMS1-like proteins is unknown; they may play a role in sphingolipid metabolism. Pssm-ID: 188914 Cd Length: 70 Bit Score: 39.16 E-value: 2.20e-04
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| SAM_LBP9 | cd09590 | SAM domain of LBP9 transcriptional factors; SAM (sterile alpha motif) domain of LBP9 (also ... |
8-44 | 3.78e-04 | ||
SAM domain of LBP9 transcriptional factors; SAM (sterile alpha motif) domain of LBP9 (also known as TFCP2L1 or CRTR-1 (CP2-Related Transcriptional Repressor-1)) transcription factor is a putative protein-protein interaction domain. Proteins of this group have an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and a C-terminal dimerization domain. They are involved in transcriptional regulation from early development to terminal differentiation. In particular, they are required for proper maturation of the dust (epithelial component of tubular organs) of kidney and salivary gland as well as for regulation of P450scc (the cholesterol side-chain cleavage enzyme, cytochrome) in human placenta. Pssm-ID: 188989 Cd Length: 67 Bit Score: 38.73 E-value: 3.78e-04
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| SAM | smart00454 | Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related ... |
4-68 | 8.69e-04 | ||
Sterile alpha motif; Widespread domain in signalling and nuclear proteins. In EPH-related tyrosine kinases, appears to mediate cell-cell initiated signal transduction via the binding of SH2-containing proteins to a conserved tyrosine that is phosphorylated. In many cases mediates homodimerisation. Pssm-ID: 197735 Cd Length: 68 Bit Score: 37.66 E-value: 8.69e-04
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| SAM_TFCP2 | cd09589 | SAM domain of TFCP2 transcription factors; SAM (sterile alpha motif) domain of TFCP2 ... |
8-43 | 1.24e-03 | ||
SAM domain of TFCP2 transcription factors; SAM (sterile alpha motif) domain of TFCP2 transcription factors is a putative protein-protein interaction domain. Proteins of this group have an N-terminal DNA-binding CP2 domain, a central predicted SAM domain and a C-terminal dimerization domain. They are involved in transcriptional regulation from early development to terminal differentiation. In particular, they regulate expression of erythroid cell-specific alpha-globin, fibrinogen, and sex-determining gene SRY as well as lens alpha-crystallin. TFCP2 regulators can interact with NF-E4 proteins forming heteromeric stage selector protein complex (SSP). This complex is able to bind stage selector element (SSE) and regulate embryonic globin expression in fetal-erythroid cells. Pssm-ID: 188988 Cd Length: 67 Bit Score: 37.27 E-value: 1.24e-03
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| SAM_superfamily | cd09487 | SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ... |
11-66 | 2.18e-03 | ||
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases. Pssm-ID: 188886 [Multi-domain] Cd Length: 56 Bit Score: 36.06 E-value: 2.18e-03
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| PAP2_like | cd01610 | PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, ... |
283-348 | 3.39e-03 | ||
PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid phosphatase, vanadium chloroperoxidases, vanadium bromoperoxidases, and several other mostly uncharacterized subfamilies. Several members of this superfamily have been predicted to be transmembrane proteins. Pssm-ID: 238813 [Multi-domain] Cd Length: 122 Bit Score: 37.44 E-value: 3.39e-03
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| SAM_1 | pfam00536 | SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily ... |
6-46 | 3.45e-03 | ||
SAM domain (Sterile alpha motif); It has been suggested that SAM is an evolutionarily conserved protein binding domain that is involved in the regulation of numerous developmental processes in diverse eukaryotes. The SAM domain can potentially function as a protein interaction module through its ability to homo- and heterooligomerise with other SAM domains. Pssm-ID: 425739 Cd Length: 64 Bit Score: 35.71 E-value: 3.45e-03
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| SAM_HD | cd09508 | SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily ... |
6-68 | 9.63e-03 | ||
SAM domain of HD-phosphohydrolase; SAM (sterile alpha motif) domain of SAM_HD subfamily proteins is a putative protein-protein interaction domain. Proteins of this group, additionally to the SAM domain, contain a HD hydrolase domain. Human SAM-HD1 is a nuclear protein involved in innate immune response and may act as a negative regulator of the cell-intrinsic antiviral response. Mutations in this gene lead to Aicardi-Goutieres syndrome (symptoms include cerebral atrophy, leukoencephalopathy, hepatosplenomegaly, and increased production of alpha-interferon). Pssm-ID: 188907 Cd Length: 70 Bit Score: 34.60 E-value: 9.63e-03
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| acidPPc | smart00014 | Acid phosphatase homologues; |
283-339 | 9.83e-03 | ||
Acid phosphatase homologues; Pssm-ID: 214471 [Multi-domain] Cd Length: 116 Bit Score: 35.78 E-value: 9.83e-03
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