NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|2024338615|ref|XP_015137936|]
View 

A disintegrin and metalloproteinase with thrombospondin motifs 20 isoform X2 [Gallus gallus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1700-1897 2.50e-113

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


:

Pssm-ID: 462559  Cd Length: 200  Bit Score: 357.70  E-value: 2.50e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615 1700 TTCKDIQIKKGMRKDGEYLLNIKGRMIKIYCSDMHLDNPKEYLTLLKGEADNFSEVYGLRLQNPYECPFNGSRRQDCACR 1779
Cdd:pfam08685    2 RSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCACR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615 1780 NDYLA-AGFTVFSKIRFDVASMQIRTTDFLFAQTILGRAVPFATAGDCYSAARCPQGQFSINLAGTGLRLSSTVRWMAQG 1858
Cdd:pfam08685   82 QDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQG 161

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2024338615 1859 NYATADIHKSHDGTKIYGRCGGFCGKCVPNTITGLQLQI 1897
Cdd:pfam08685  162 NYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 253-459 5.39e-112

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 353.85  E-value: 5.39e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  253 RYVEVMVTADTKMVR-HHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLIIIHNEQEGPTITFNAATTLRNFCIWQ 331
Cdd:cd04273      1 RYVETLVVADSKMVEfHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  332 QAQNILDDAHPSHHDTAVLITREDICRAREKCDTLGLAELGTMCDPLRSCSISEENGLSAAFTIAHELGHVFNVPHDDSF 411
Cdd:cd04273     81 KKLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2024338615  412 K-CKEAGikHQYHVMAPTLNYHTSPWTWSKCSQKYITEFLDTGYGECLL 459
Cdd:cd04273    161 NsCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 41-177 1.73e-35

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 132.05  E-value: 1.73e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615   41 EIVTPVRVNEFgevfphtrhfsRRKRSSEPAAL---RTHYRLSAYGQLFQLNLSADAGFIAAHFAA---LHVGAPRQPPS 114
Cdd:pfam01562    1 EVVIPVRLDPS-----------RRRRSLASESTyldTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVtyyLDGGTGVESPP 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024338615  115 PDLRHCFYRGHVNAQQAHVAVLSVCGGLMGTFKAHDGEYFLEPLMKtdggEHEDEHNKPHLIY 177
Cdd:pfam01562   70 VQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 720-826 1.97e-31

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


:

Pssm-ID: 461796  Cd Length: 115  Bit Score: 119.61  E-value: 1.97e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  720 GYNVVVKIPKGATNIDIRQHSYSGkpeddNYLALSDIHGNFILNGNFVVSMSKREINIHGAIFEYNGSNNTVERINSTDR 799
Cdd:pfam05986   13 GYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRSLPALEELHAPGP 87

                           90       100
                   ....*....|....*....|....*...
gi 2024338615  800 IEEELTLQVLCV-GNLYNPDVRYSFNIP 826
Cdd:pfam05986   88 TQEDLEIQVLRQyGKGTNPGITYEYFIP 115
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 474-541 2.10e-18

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 80.85  E-value: 2.10e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  474 PGLMYDVNKQCELMFGLGSQVCPYLKQ--CKRLWCTSTEGvhKGCRTQHMPLADGTVCGVGMHCRHGICV 541
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1348-1401 2.03e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 69.02  E-value: 2.03e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1348 WNYGNWGECTQTCGDGIKTRLVICQLPTGQ-MLGDQNCEILDKPPNMAQCNVHSC 1401
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1066-1121 5.08e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.86  E-value: 5.08e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024338615 1066 WQVGPWGACTVTCGRGYQMRAVRCVTGTYRvILDDDRECNAATRPRDNQECELPSC 1121
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGG-SIVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 554-606 1.94e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 66.46  E-value: 1.94e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024338615   554 WGPWGPYSSCSRTCGGGIKSTTRLCNRPEPRNGGKYCVGRRMKFRSCNTDSCP 606
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1294-1345 8.80e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.40  E-value: 8.80e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1294 WRTGPWGACSSTCAGGFHRRVVVCQDEEGRSA---SYCDEASKPPESRHCDSGPC 1345
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvpdSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1198-1250 7.12e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.09  E-value: 7.12e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1198 WQVGNWSPCTVTCDSGIITRQVICVNYHQQI--NENYCDPEGRPSKEQECNMPPC 1250
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSivPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 super family cl41950
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 611-715 2.54e-11

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


The actual alignment was detected with superfamily member pfam19236:

Pssm-ID: 437068  Cd Length: 115  Bit Score: 62.42  E-value: 2.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  611 DFREQQCSEFDGKHFNIN-GLTSAVRW---LPKYSGISMkdrCKLFCRVSGTTSYYQLKDRVADGTPCGAE------TND 680
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024338615  681 LCVQGLCRQAGCDHVLNSKARRDKCGICGGDNSSC 715
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1143-1195 4.38e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.77  E-value: 4.38e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1143 WRYGSWTPCSASCGKGDRARYVSCRDAHGGIA-DESFCAHLPRPAEVSSCFS-PC 1195
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKPPETQSCNLkPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1407-1460 6.42e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 6.42e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1407 WHRGPWKSCSVSCGKGLKHRDVHCFNSF-RAKVEDGNCRHLKKPRTYKICRAGRC 1460
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1011-1063 4.32e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 4.32e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1011 WSASEWSECPVTCGKGMKHRQVWCQ--LNDEQLRDDFCNLNDRPGSVTPCELPEC 1063
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1463-1516 1.76e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 1.76e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1463 WKTSGWKECSVSCGVGIQQRDIYC-QLKGLGKVSEAMCNHNARPAGHRPCWLPAC 1516
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1645-1696 2.04e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.07  E-value: 2.04e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1645 WRVGKWTKCSVSCGAGVKERTVACMTENGLS---SDLCLPHLKPDNRRICHTEEC 1696
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSivpDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 956-1008 5.39e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 5.39e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615  956 WHYAEWSECSRSCERGIRTREAFCLNNLGRHL-PDRECQELPR-VVTESCNEFLC 1008
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKpPETQSCNLKPC 55
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 836-887 9.10e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.75  E-value: 9.10e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024338615  836 WDpYGPWQDCSRMC-QGIRRRRMTCIRKSDHVVVSDQRCEHiPPVPDVSEECN 887
Cdd:pfam19030    1 WV-AGPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSA-QKKPPETQSCN 51
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1521-1573 1.44e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.59  E-value: 1.44e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615 1521 WLADGWENCSTSYRRKEIHQKVKCVDEK-QIQVDESFCDPATKPPSVKNCRRAP 1573
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKPPETQSCNLKP 54
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 894-947 8.31e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.28  E-value: 8.31e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615  894 WHsIGK-SDCTSKCGPGYRSIEIHCMKysvsKGLSALVDDRYCADQQKPPTREAC 947
Cdd:pfam19030    1 WV-AGPwGECSVTCGGGVQTRLVQCVQ----KGGGSIVPDSECSAQKKPPETQSC 50
 
Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1700-1897 2.50e-113

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 357.70  E-value: 2.50e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615 1700 TTCKDIQIKKGMRKDGEYLLNIKGRMIKIYCSDMHLDNPKEYLTLLKGEADNFSEVYGLRLQNPYECPFNGSRRQDCACR 1779
Cdd:pfam08685    2 RSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCACR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615 1780 NDYLA-AGFTVFSKIRFDVASMQIRTTDFLFAQTILGRAVPFATAGDCYSAARCPQGQFSINLAGTGLRLSSTVRWMAQG 1858
Cdd:pfam08685   82 QDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQG 161

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2024338615 1859 NYATADIHKSHDGTKIYGRCGGFCGKCVPNTITGLQLQI 1897
Cdd:pfam08685  162 NYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 253-459 5.39e-112

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 353.85  E-value: 5.39e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  253 RYVEVMVTADTKMVR-HHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLIIIHNEQEGPTITFNAATTLRNFCIWQ 331
Cdd:cd04273      1 RYVETLVVADSKMVEfHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  332 QAQNILDDAHPSHHDTAVLITREDICRAREKCDTLGLAELGTMCDPLRSCSISEENGLSAAFTIAHELGHVFNVPHDDSF 411
Cdd:cd04273     81 KKLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2024338615  412 K-CKEAGikHQYHVMAPTLNYHTSPWTWSKCSQKYITEFLDTGYGECLL 459
Cdd:cd04273    161 NsCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 41-177 1.73e-35

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 132.05  E-value: 1.73e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615   41 EIVTPVRVNEFgevfphtrhfsRRKRSSEPAAL---RTHYRLSAYGQLFQLNLSADAGFIAAHFAA---LHVGAPRQPPS 114
Cdd:pfam01562    1 EVVIPVRLDPS-----------RRRRSLASESTyldTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVtyyLDGGTGVESPP 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024338615  115 PDLRHCFYRGHVNAQQAHVAVLSVCGGLMGTFKAHDGEYFLEPLMKtdggEHEDEHNKPHLIY 177
Cdd:pfam01562   70 VQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 720-826 1.97e-31

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 119.61  E-value: 1.97e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  720 GYNVVVKIPKGATNIDIRQHSYSGkpeddNYLALSDIHGNFILNGNFVVSMSKREINIHGAIFEYNGSNNTVERINSTDR 799
Cdd:pfam05986   13 GYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRSLPALEELHAPGP 87

                           90       100
                   ....*....|....*....|....*...
gi 2024338615  800 IEEELTLQVLCV-GNLYNPDVRYSFNIP 826
Cdd:pfam05986   88 TQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 253-462 1.24e-30

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 120.48  E-value: 1.24e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  253 RYVEVMVTADTKMVRHHGQNLQH---YVLTLMSIVAAIYKDSSIgnliNIVIVKLIIiHNEQEGPTITFNAATTLRNFCI 329
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqRVFQVVNLVNSIYKELNI----RVVLVGLEI-WTDEDKIDVSGDANDTLRNFLK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  330 WQQaQNILddaHPSHHDTAVLITREDIcrareKCDTLGLAELGTMCDPLRSCSISE---ENGLSAAFTIAHELGHVFNVP 406
Cdd:pfam01421   76 WRQ-EYLK---KRKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEdhsKNLESFAVTMAHELGHNLGMQ 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024338615  407 HDDSF---KCKEAGIkhqyHVMAPTLNyHTSPWTWSKCSQKYITEFLDTGYGECLLDKP 462
Cdd:pfam01421  147 HDDFNggcKCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 474-541 2.10e-18

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 80.85  E-value: 2.10e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  474 PGLMYDVNKQCELMFGLGSQVCPYLKQ--CKRLWCTSTEGvhKGCRTQHMPLADGTVCGVGMHCRHGICV 541
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1348-1401 2.03e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 69.02  E-value: 2.03e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1348 WNYGNWGECTQTCGDGIKTRLVICQLPTGQ-MLGDQNCEILDKPPNMAQCNVHSC 1401
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1066-1121 5.08e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.86  E-value: 5.08e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024338615 1066 WQVGPWGACTVTCGRGYQMRAVRCVTGTYRvILDDDRECNAATRPRDNQECELPSC 1121
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGG-SIVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 554-606 1.94e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 66.46  E-value: 1.94e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024338615   554 WGPWGPYSSCSRTCGGGIKSTTRLCNRPEPRNGGKYCVGRRMKFRSCNTDSCP 606
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1294-1345 8.80e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.40  E-value: 8.80e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1294 WRTGPWGACSSTCAGGFHRRVVVCQDEEGRSA---SYCDEASKPPESRHCDSGPC 1345
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvpdSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1198-1250 7.12e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.09  E-value: 7.12e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1198 WQVGNWSPCTVTCDSGIITRQVICVNYHQQI--NENYCDPEGRPSKEQECNMPPC 1250
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSivPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 611-715 2.54e-11

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 62.42  E-value: 2.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  611 DFREQQCSEFDGKHFNIN-GLTSAVRW---LPKYSGISMkdrCKLFCRVSGTTSYYQLKDRVADGTPCGAE------TND 680
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024338615  681 LCVQGLCRQAGCDHVLNSKARRDKCGICGGDNSSC 715
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1143-1195 4.38e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.77  E-value: 4.38e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1143 WRYGSWTPCSASCGKGDRARYVSCRDAHGGIA-DESFCAHLPRPAEVSSCFS-PC 1195
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKPPETQSCNLkPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1407-1460 6.42e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 6.42e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1407 WHRGPWKSCSVSCGKGLKHRDVHCFNSF-RAKVEDGNCRHLKKPRTYKICRAGRC 1460
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1011-1063 4.32e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 4.32e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1011 WSASEWSECPVTCGKGMKHRQVWCQ--LNDEQLRDDFCNLNDRPGSVTPCELPEC 1063
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1463-1516 1.76e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 1.76e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1463 WKTSGWKECSVSCGVGIQQRDIYC-QLKGLGKVSEAMCNHNARPAGHRPCWLPAC 1516
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1645-1696 2.04e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.07  E-value: 2.04e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1645 WRVGKWTKCSVSCGAGVKERTVACMTENGLS---SDLCLPHLKPDNRRICHTEEC 1696
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSivpDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1195-1251 2.80e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.82  E-value: 2.80e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024338615  1195 CGEWqvGNWSPCTVTCDSGIITRQVICVNYHQQINENYCDpeGRPSKEQECNMPPCP 1251
Cdd:smart00209    1 WSEW--SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT--GEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 956-1008 5.39e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 5.39e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615  956 WHYAEWSECSRSCERGIRTREAFCLNNLGRHL-PDRECQELPR-VVTESCNEFLC 1008
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKpPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
555-605 6.68e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 47.80  E-value: 6.68e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024338615  555 GPWGPYSSCSRTCGGGIKSTTRLCNRPEPrnGGKYCVGRRMKFRSCNTDSC 605
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 956-1009 1.54e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.81  E-value: 1.54e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615   956 WHYAEWSECSRSCERGIRTREAFCLNNLGRHlPDRECQElPRVVTESCNEFLCP 1009
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTG-EDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1011-1063 7.88e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.89  E-value: 7.88e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615  1011 WSA-SEWSECPVTCGKGMKHRQVWCQLNDEQLRDDFCNLNDRpgSVTPCELPEC 1063
Cdd:smart00209    1 WSEwSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 836-887 9.10e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.75  E-value: 9.10e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024338615  836 WDpYGPWQDCSRMC-QGIRRRRMTCIRKSDHVVVSDQRCEHiPPVPDVSEECN 887
Cdd:pfam19030    1 WV-AGPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSA-QKKPPETQSCN 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1066-1122 3.94e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 3.94e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024338615  1066 WQVGPWGACTVTCGRGYQMRAVRCVTGTYRVildDDRECNAATrpRDNQECELPSCP 1122
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN---GGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1348-1402 6.25e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 6.25e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615  1348 WNYGNWGECTQTCGDGIKTRLVICQLPTGQmLGDQNCEILDkpPNMAQCNVHSCP 1402
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1294-1346 1.22e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.22e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615  1294 WRTGPWGACSSTCAGGFHRRVVVCQDEEGR-SASYCDEASkpPESRHCDSGPCP 1346
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQnGGGPCTGED--VETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1521-1573 1.44e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.59  E-value: 1.44e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615 1521 WLADGWENCSTSYRRKEIHQKVKCVDEK-QIQVDESFCDPATKPPSVKNCRRAP 1573
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKPPETQSCNLKP 54
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1410-1461 3.37e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 3.37e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024338615  1410 GPWKSCSVSCGKGLKHRDVHCfNSFRAKVEDGNCRHLKkpRTYKICRAGRCP 1461
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 894-947 8.31e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.28  E-value: 8.31e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615  894 WHsIGK-SDCTSKCGPGYRSIEIHCMKysvsKGLSALVDDRYCADQQKPPTREAC 947
Cdd:pfam19030    1 WV-AGPwGECSVTCGGGVQTRLVQCVQ----KGGGSIVPDSECSAQKKPPETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1143-1171 9.21e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 9.21e-03
                            10        20
                    ....*....|....*....|....*....
gi 2024338615  1143 WRYGSWTPCSASCGKGDRARYVSCRDAHG 1171
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPP 30
 
Name Accession Description Interval E-value
GON pfam08685
GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain ...
 1700-1897 2.50e-113

GON domain; The GON domain is found in the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) family of proteins. It contains several conserved cysteine residues.


Pssm-ID: 462559  Cd Length: 200  Bit Score: 357.70  E-value: 2.50e-113
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615 1700 TTCKDIQIKKGMRKDGEYLLNIKGRMIKIYCSDMHLDNPKEYLTLLKGEADNFSEVYGLRLQNPYECPFNGSRRQDCACR 1779
Cdd:pfam08685    2 RSCKEIQSRSGVRKDGEYTLNVRGRNVRIYCHGMNTSSPKEYLTLPSGPQENYSEVYGYRLKNPNECPFNGSRRDDCACR 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615 1780 NDYLA-AGFTVFSKIRFDVASMQIRTTDFLFAQTILGRAVPFATAGDCYSAARCPQGQFSINLAGTGLRLSSTVRWMAQG 1858
Cdd:pfam08685   82 QDYPAnAGTTTFSKVRLDLTSLRIITNDFTFARTIRGKPVPFGTAGDCYSAAKCPQGRFSINLTGTGLRVSPDTKWVSQG 161

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 2024338615 1859 NYATADIHKSHDGTKIYGRCGGFCGKCVPNTITGLQLQI 1897
Cdd:pfam08685  162 NYAVSKIHRSQDGTKVRGRCGGYCGKCTPSPGTGLLLDV 200
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 253-459 5.39e-112

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 353.85  E-value: 5.39e-112
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  253 RYVEVMVTADTKMVR-HHGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLIIIHNEQEGPTITFNAATTLRNFCIWQ 331
Cdd:cd04273      1 RYVETLVVADSKMVEfHHGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLLISGNAQKSLKSFCRWQ 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  332 QAQNILDDAHPSHHDTAVLITREDICRAREKCDTLGLAELGTMCDPLRSCSISEENGLSAAFTIAHELGHVFNVPHDDSF 411
Cdd:cd04273     81 KKLNPPNDSDPEHHDHAILLTRQDICRSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELGHVLGMPHDGDG 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*....
gi 2024338615  412 K-CKEAGikHQYHVMAPTLNYHTSPWTWSKCSQKYITEFLDTGYGECLL 459
Cdd:cd04273    161 NsCGPEG--KDGHIMSPTLGANTGPFTWSKCSRRYLTSFLDTGDGNCLL 207
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 253-451 1.88e-53

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 185.70  E-value: 1.88e-53
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  253 RYVEVMVTADTKMVRH---HGQNLQHYVLTLMSIVAAIYKDSSIGNLINIVIVKLIIIHNEQEGPTITFNAATTLRNFCI 329
Cdd:cd04267      1 REIELVVVADHRMVSYfnsDENILQAYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPIDSDASNTLNSFSF 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  330 WQQAQnilddahPSHHDTAVLITREDIcrarEKCDTLGLAELGTMCDPLRSCSISEENG--LSAAFTIAHELGHVFNVPH 407
Cdd:cd04267     81 WRAEG-------PIRHDNAVLLTAQDF----IEGDILGLAYVGSMCNPYSSVGVVEDTGftLLTALTMAHELGHNLGAEH 149

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 2024338615  408 DDSFKCKEAGIKHQYHVMAPTLNYhTSPWTWSKCSQKYITEFLD 451
Cdd:cd04267    150 DGGDELAFECDGGGNYIMAPVDSG-LNSYRFSQCSIGSIREFLD 192
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 41-177 1.73e-35

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 132.05  E-value: 1.73e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615   41 EIVTPVRVNEFgevfphtrhfsRRKRSSEPAAL---RTHYRLSAYGQLFQLNLSADAGFIAAHFAA---LHVGAPRQPPS 114
Cdd:pfam01562    1 EVVIPVRLDPS-----------RRRRSLASESTyldTLSYRLAAFGKKFHLHLTPNRLLLAPGFTVtyyLDGGTGVESPP 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2024338615  115 PDLRHCFYRGHVNAQQAHVAVLSVCGGLMGTFKAHDGEYFLEPLMKtdggEHEDEHNKPHLIY 177
Cdd:pfam01562   70 VQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEYLIEPLEK----YSREEGGHPHVVY 128
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 253-460 1.30e-34

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 131.97  E-value: 1.30e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  253 RYVEVMVTADTKMVRHHGQNL---QHYVLTLMSIVAAIYKDSSIgnlinIVIVKLIIIHNEQEGPTITFNAATTLRNFCI 329
Cdd:cd04269      1 KYVELVVVVDNSLYKKYGSNLskvRQRVIEIVNIVDSIYRPLNI-----RVVLVGLEIWTDKDKISVSGDAGETLNRFLD 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  330 WQQaqNILDDAHPshHDTAVLITREDICRarekcDTLGLAELGTMCDPLRSCSISE---ENGLSAAFTIAHELGHVFNVP 406
Cdd:cd04269     76 WKR--SNLLPRKP--HDNAQLLTGRDFDG-----NTVGLAYVGGMCSPKYSGGVVQdhsRNLLLFAVTMAHELGHNLGME 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615  407 HDDSF-KCKEAGIkhqyhVMAPTLNYHTspWTWSKCSQKYITEFLDTGYGECLLD 460
Cdd:cd04269    147 HDDGGcTCGRSTC-----IMAPSPSSLT--DAFSNCSYEDYQKFLSRGGGQCLLN 194
ADAMTS_spacer1 pfam05986
ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like ...
 720-826 1.97e-31

ADAM-TS Spacer 1; This domain represents the Spacer-1 region from the ADAM-TS and ADAM-TS-like proteins. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase) and is a subfamily of the metalloprotease family, sharing a high degree of sequence similarity and conserved domain organization among its members. Members of the ADAM-TS family have been implicated in a range of diseases. ADAM-TS-like proteins lack a metalloprotease domain. They resides in the ECM and have regulatory roles. Examples of ADAM-TS-like proteins are papilin and punctin.


Pssm-ID: 461796  Cd Length: 115  Bit Score: 119.61  E-value: 1.97e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  720 GYNVVVKIPKGATNIDIRQHSYSGkpeddNYLALSDIHGNFILNGNFVVSMSKREINIHGAIFEYNGSNNTVERINSTDR 799
Cdd:pfam05986   13 GYVTFVTIPAGATHIHIVNRKPSF-----THLAVKNVQGKYILNGKGSISLNPTYPSLLGTVLEYRRSLPALEELHAPGP 87

                           90       100
                   ....*....|....*....|....*...
gi 2024338615  800 IEEELTLQVLCV-GNLYNPDVRYSFNIP 826
Cdd:pfam05986   88 TQEDLEIQVLRQyGKGTNPGITYEYFIP 115
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 253-462 1.24e-30

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 120.48  E-value: 1.24e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  253 RYVEVMVTADTKMVRHHGQNLQH---YVLTLMSIVAAIYKDSSIgnliNIVIVKLIIiHNEQEGPTITFNAATTLRNFCI 329
Cdd:pfam01421    1 KYIELFIVVDKQLFQKMGSDTTVvrqRVFQVVNLVNSIYKELNI----RVVLVGLEI-WTDEDKIDVSGDANDTLRNFLK 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  330 WQQaQNILddaHPSHHDTAVLITREDIcrareKCDTLGLAELGTMCDPLRSCSISE---ENGLSAAFTIAHELGHVFNVP 406
Cdd:pfam01421   76 WRQ-EYLK---KRKPHDVAQLLSGVEF-----GGTTVGAAYVGGMCSLEYSGGVNEdhsKNLESFAVTMAHELGHNLGMQ 146

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 2024338615  407 HDDSF---KCKEAGIkhqyHVMAPTLNyHTSPWTWSKCSQKYITEFLDTGYGECLLDKP 462
Cdd:pfam01421  147 HDDFNggcKCPPGGG----CIMNPSAG-SSFPRKFSNCSQEDFEQFLTKQKGACLFNKP 200
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 253-450 1.99e-22

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 96.05  E-value: 1.99e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  253 RYVEVMVTADTKMVrhHGQNLQHYVLTLMSIVAAIYKDSsigNLINIVIVKLIIIHneqegptitfnaattlrnfciwqq 332
Cdd:cd00203      1 KVIPYVVVADDRDV--EEENLSAQIQSLILIAMQIWRDY---LNIRFVLVGVEIDK------------------------ 51

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  333 aqnilddahpshHDTAVLITREDIcrareKCDTLGLAELGTMCDPLRSCSISEENGL---SAAFTIAHELGHVFNVPHDD 409
Cdd:cd00203     52 ------------ADIAILVTRQDF-----DGGTGGWAYLGRVCDSLRGVGVLQDNQSgtkEGAQTIAHELGHALGFYHDH 114

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024338615  410 SFKCKEAGIKH----------QYHVMAPTL--NYHTSPWTWSKCSQKYITEFL 450
Cdd:cd00203    115 DRKDRDDYPTIddtlnaedddYYSVMSYTKgsFSDGQRKDFSQCDIDQINKLY 167
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 474-541 2.10e-18

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 80.85  E-value: 2.10e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  474 PGLMYDVNKQCELMFGLGSQVCPYLKQ--CKRLWCTSTEGvhKGCRTQHMPLADGTVCGVGMHCRHGICV 541
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTFCPNGDEdvCSKLWCSNPGG--STCTTKNLPAADGTPCGNKKWCLNGKCV 68
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1348-1401 2.03e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 69.02  E-value: 2.03e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1348 WNYGNWGECTQTCGDGIKTRLVICQLPTGQ-MLGDQNCEILDKPPNMAQCNVHSC 1401
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGsIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1066-1121 5.08e-14

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 67.86  E-value: 5.08e-14
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024338615 1066 WQVGPWGACTVTCGRGYQMRAVRCVTGTYRvILDDDRECNAATRPRDNQECELPSC 1121
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGG-SIVPDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 554-606 1.94e-13

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 66.46  E-value: 1.94e-13
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 2024338615   554 WGPWGPYSSCSRTCGGGIKSTTRLCNRPEPRNGGKYCVGRRMKFRSCNTDSCP 606
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1294-1345 8.80e-13

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 64.40  E-value: 8.80e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1294 WRTGPWGACSSTCAGGFHRRVVVCQDEEGRSA---SYCDEASKPPESRHCDSGPC 1345
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvpdSECSAQKKPPETQSCNLKPC 55
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 254-458 5.35e-12

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 67.38  E-value: 5.35e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  254 YVEVMVTADTKMVRHHGQNLQ--HYVLTLMSIVAAIYKDSSIGNlINIVIVKLIIIHNEQEGPTI------TFNAATTLR 325
Cdd:cd04272      2 YPELFVVVDYDHQSEFFSNEQliRYLAVMVNAANLRYRDLKSPR-IRLLLVGITISKDPDFEPYIhpinygYIDAAETLE 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  326 NFciwqqAQNILDDAHPSHHDTAVLITREDICRARE-KCDT--LGLAELGTMCDPLRsCSISEENGLS--AAFTIAHELG 400
Cdd:cd04272     81 NF-----NEYVKKKRDYFNPDVVFLVTGLDMSTYSGgSLQTgtGGYAYVGGACTENR-VAMGEDTPGSyyGVYTMTHELA 154

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2024338615  401 HVFNVPHD------------DSFKCK-EAGikhqyHVMApTLNYHTSPWTWSKCSQKYITEFLDTGYGECL 458
Cdd:cd04272    155 HLLGAPHDgspppswvkghpGSLDCPwDDG-----YIMS-YVVNGERQYRFSQCSQRQIRNVFRRLGASCL 219
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1198-1250 7.12e-12

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 62.09  E-value: 7.12e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1198 WQVGNWSPCTVTCDSGIITRQVICVNYHQQI--NENYCDPEGRPSKEQECNMPPC 1250
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSivPDSECSAQKKPPETQSCNLKPC 55
ADAMTS_CR_3 pfam19236
ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ...
 611-715 2.54e-11

ADAMTS cysteine-rich domain; This cysteine rich domain is found in a variety of ADAMTS and ADAMTS-like endopeptidases widely spread in animals. It is a well-conserved cysteine-rich sequence containing 10 cysteine residues. ADAM-TS (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) is closely related to the ADAM family (A Disintegrin and Metalloproteinase, pfam08516) and consists of at least 20 members sharing a high degree of sequence similarity and conserved domain organization. Members of the ADAMTS family have been implicated in a range of diseases.


Pssm-ID: 437068  Cd Length: 115  Bit Score: 62.42  E-value: 2.54e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  611 DFREQQCSEFDGKHFNIN-GLTSAVRW---LPKYSGISMkdrCKLFCRVSGTTSYYQLKDRVADGTPCGAE------TND 680
Cdd:pfam19236    4 EFMSQQCARTDGQPLRSSpGGASFYHWgaaVPHSQGDAL---CRHMCRAIGESFIMKRGDSFLDGTRCMPSgpredgTLS 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 2024338615  681 LCVQGLCRQAGCDHVLNSKARRDKCGICGGDNSSC 715
Cdd:pfam19236   81 LCVLGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC 115
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1143-1195 4.38e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.77  E-value: 4.38e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1143 WRYGSWTPCSASCGKGDRARYVSCRDAHGGIA-DESFCAHLPRPAEVSSCFS-PC 1195
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKPPETQSCNLkPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1407-1460 6.42e-11

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 59.39  E-value: 6.42e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1407 WHRGPWKSCSVSCGKGLKHRDVHCFNSF-RAKVEDGNCRHLKKPRTYKICRAGRC 1460
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1011-1063 4.32e-10

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 57.08  E-value: 4.32e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1011 WSASEWSECPVTCGKGMKHRQVWCQ--LNDEQLRDDFCNLNDRPGSVTPCELPEC 1063
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVqkGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1463-1516 1.76e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.46  E-value: 1.76e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1463 WKTSGWKECSVSCGVGIQQRDIYC-QLKGLGKVSEAMCNHNARPAGHRPCWLPAC 1516
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCvQKGGGSIVPDSECSAQKKPPETQSCNLKPC 55
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1645-1696 2.04e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 52.07  E-value: 2.04e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1645 WRVGKWTKCSVSCGAGVKERTVACMTENGLS---SDLCLPHLKPDNRRICHTEEC 1696
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSivpDSECSAQKKPPETQSCNLKPC 55
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1195-1251 2.80e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 51.82  E-value: 2.80e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024338615  1195 CGEWqvGNWSPCTVTCDSGIITRQVICVNYHQQINENYCDpeGRPSKEQECNMPPCP 1251
Cdd:smart00209    1 WSEW--SEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCT--GEDVETRACNEQPCP 53
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
251-408 2.80e-07

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 52.81  E-value: 2.80e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  251 YPRYVEVMVTADTKMVRHHGQN-LQHYVLTLM-SIVAAIYKDSSIgnliNIVIVKLIIIHNE---QEGPTITFNAATTLR 325
Cdd:pfam13688    1 STRTVALLVAADCSYVAAFGGDaAQANIINMVnTASNVYERDFNI----SLGLVNLTISDSTcpyTPPACSTGDSSDRLS 76

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  326 NFciwqQAQNILDDAHpsHHDTAVLITREDicrarekCDTLGLAELGTMCDPLRSCSISEENG--------LSAAFTIAH 397
Cdd:pfam13688   77 EF----QDFSAWRGTQ--NDDLAYLFLMTN-------CSGGGLAWLGQLCNSGSAGSVSTRVSgnnvvvstATEWQVFAH 143

                          170
                   ....*....|.
gi 2024338615  398 ELGHVFNVPHD 408
Cdd:pfam13688  144 EIGHNFGAVHD 154
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 956-1008 5.39e-07

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 5.39e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615  956 WHYAEWSECSRSCERGIRTREAFCLNNLGRHL-PDRECQELPR-VVTESCNEFLC 1008
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGGGSIvPDSECSAQKKpPETQSCNLKPC 55
TSP_1 pfam00090
Thrombospondin type 1 domain;
555-605 6.68e-07

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 47.80  E-value: 6.68e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 2024338615  555 GPWGPYSSCSRTCGGGIKSTTRLCNRPEPrnGGKYCVGRRMKFRSCNTDSC 605
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 552-605 1.21e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.89  E-value: 1.21e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615  552 GEWGPWgpySSCSRTCGGGIKSTTRLCNRPePRNGGKYCvGRRMKFRSCNTDSC 605
Cdd:pfam19028    4 SEWSEW---SECSVTCGGGVQTRTRTVIVE-PQNGGRPC-PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 956-1009 1.54e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 46.81  E-value: 1.54e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615   956 WHYAEWSECSRSCERGIRTREAFCLNNLGRHlPDRECQElPRVVTESCNEFLCP 1009
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN-GGGPCTG-EDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1011-1063 7.88e-06

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.89  E-value: 7.88e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615  1011 WSA-SEWSECPVTCGKGMKHRQVWCQLNDEQLRDDFCNLNDRpgSVTPCELPEC 1063
Cdd:smart00209    1 WSEwSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDV--ETRACNEQPC 52
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 836-887 9.10e-06

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 44.75  E-value: 9.10e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 2024338615  836 WDpYGPWQDCSRMC-QGIRRRRMTCIRKSDHVVVSDQRCEHiPPVPDVSEECN 887
Cdd:pfam19030    1 WV-AGPWGECSVTCgGGVQTRLVQCVQKGGGSIVPDSECSA-QKKPPETQSCN 51
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 276-408 4.41e-05

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 44.67  E-value: 4.41e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  276 YVLTLMSIVAAIY-KDSSIG-NLINIVIVkliiihNEQEGPTITFNAATTLRNFCIWQQAQNILDDAhpshhDTAVLITR 353
Cdd:pfam13582    2 RIVSLVNRANTIYeRDLGIRlQLAAIIIT------TSADTPYTSSDALEILDELQEVNDTRIGQYGY-----DLGHLFTG 70

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 2024338615  354 EDicrareKCDTLGLAELGTMCDPLRSCSISE---ENGLSAAFTIAHELGHVFNVPHD 408
Cdd:pfam13582   71 RD------GGGGGGIAYVGGVCNSGSKFGVNSgsgPVGDTGADTFAHEIGHNFGLNHT 122
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 271-450 8.79e-05

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 45.31  E-value: 8.79e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  271 QNLQHYVLTLMSIVAAIYKDSSIGnlINIVIVkliiihNEQEGPTITfNAATTLRNFC---IWQ-QAQNILDDAH-PSHH 345
Cdd:pfam13574    1 GNVTENLVNVVNRVNQIYEPDDIN--INGGLV------NPGEIPATT-SASDSGNNYCnspTTIvRRLNFLSQWRgEQDY 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024338615  346 DTAVLITREDICRArekcdTLGLAELGTMCDPLRSCsISEENGLSAAFT-------------IAHELGHVFNVPHDD--- 409
Cdd:pfam13574   72 CLAHLVTMGTFSGG-----ELGLAYVGQICQKGASS-PKTNTGLSTTTNygsfnyptqewdvVAHEVGHNFGATHDCdgs 145

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 2024338615  410 ------------SFKCKEAGikhqYHVMAPT---LNYHTSPwtwskCSQKYITEFL 450
Cdd:pfam13574  146 qyassgcernaaTSVCSANG----SFIMNPAsksNNDLFSP-----CSISLICDVL 192
TSP_1 pfam00090
Thrombospondin type 1 domain;
1014-1063 1.03e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 41.63  E-value: 1.03e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 2024338615 1014 SEWSECPVTCGKGMKHRQVWCQLNDEQlrDDFCNLNDRPgsVTPCELPEC 1063
Cdd:pfam00090    4 SPWSPCSVTCGKGIQVRQRTCKSPFPG--GEPCTGDDIE--TQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1066-1122 3.94e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.88  E-value: 3.94e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 2024338615  1066 WQVGPWGACTVTCGRGYQMRAVRCVTGTYRVildDDRECNAATrpRDNQECELPSCP 1122
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQN---GGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1348-1402 6.25e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 39.49  E-value: 6.25e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615  1348 WNYGNWGECTQTCGDGIKTRLVICQLPTGQmLGDQNCEILDkpPNMAQCNVHSCP 1402
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQ-NGGGPCTGED--VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1294-1346 1.22e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 38.72  E-value: 1.22e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615  1294 WRTGPWGACSSTCAGGFHRRVVVCQDEEGR-SASYCDEASkpPESRHCDSGPCP 1346
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPPQnGGGPCTGED--VETRACNEQPCP 53
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1521-1573 1.44e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.59  E-value: 1.44e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 2024338615 1521 WLADGWENCSTSYRRKEIHQKVKCVDEK-QIQVDESFCDPATKPPSVKNCRRAP 1573
Cdd:pfam19030    1 WVAGPWGECSVTCGGGVQTRLVQCVQKGgGSIVPDSECSAQKKPPETQSCNLKP 54
TSP_1 pfam00090
Thrombospondin type 1 domain;
1196-1250 1.48e-03

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 38.17  E-value: 1.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615 1196 GEWqvGNWSPCTVTCDSGIITRQVICVnyHQQINENYCDPEGRPSkeQECNMPPC 1250
Cdd:pfam00090    1 SPW--SPWSPCSVTCGKGIQVRQRTCK--SPFPGGEPCTGDDIET--QACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1014-1031 3.27e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 3.27e-03
                           10
                   ....*....|....*...
gi 2024338615 1014 SEWSECPVTCGKGMKHRQ 1031
Cdd:pfam19028    7 SEWSECSVTCGGGVQTRT 24
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1410-1461 3.37e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 3.37e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 2024338615  1410 GPWKSCSVSCGKGLKHRDVHCfNSFRAKVEDGNCRHLKkpRTYKICRAGRCP 1461
Cdd:smart00209    5 SEWSPCSVTCGGGVQTRTRSC-CSPPPQNGGGPCTGED--VETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 951-975 5.57e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 36.87  E-value: 5.57e-03
                           10        20
                   ....*....|....*....|....*
gi 2024338615  951 CMLTSWhyAEWSECSRSCERGIRTR 975
Cdd:pfam19028    1 CVVSEW--SEWSECSVTCGGGVQTR 23
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 894-947 8.31e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.28  E-value: 8.31e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 2024338615  894 WHsIGK-SDCTSKCGPGYRSIEIHCMKysvsKGLSALVDDRYCADQQKPPTREAC 947
Cdd:pfam19030    1 WV-AGPwGECSVTCGGGVQTRLVQCVQ----KGGGSIVPDSECSAQKKPPETQSC 50
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1143-1171 9.21e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.03  E-value: 9.21e-03
                            10        20
                    ....*....|....*....|....*....
gi 2024338615  1143 WRYGSWTPCSASCGKGDRARYVSCRDAHG 1171
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPPP 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH