|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
24-483 |
0e+00 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 655.15 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 24 HIVVFLLTFFSYSLLHASRKTFSNVKVSISSQWTPSCLNSTTFELrpNELWNSNHLFPNAEEATLFLGTLDTIFLFSYAV 103
Cdd:cd17342 1 HVVVFILTFFSYALLHATRKTFSNVKPSISAEWTPSNSNTSIELH--EETWNANPLFPSQDDAALFLGVLDTIFLFSYAI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 104 GLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHFYNKWFYCCLWVVNGLLQSTGWPCVVAVMGNWFGKAGRGF 183
Cdd:cd17342 79 GLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYNKYLYCILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 184 VFGLWSACASVGNILGAFLASCVLKYGYEYAFLVTASVQFAGGVIVFCGLLTSPkevglpelgadeegsveedanrplmg 263
Cdd:cd17342 159 VLGLWSACASVGNIIGALLASSVLDYGYEYAFLVTSSLLFAGAIVVFFGLLSSP-------------------------- 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 264 dddadddegnysiqaadtdsqpkaigffqacclPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADQLSIWYD 343
Cdd:cd17342 213 ---------------------------------PGVIPYSLAYACLKLVNYSFFFWLPFYLSNNFHWKESEADQLSIWYD 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 344 VGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYSRSPNSKPINAVIMAITGFFIGGPSNMISSAISADLGRQDLV 423
Cdd:cd17342 260 VGGIIGGIVAGYISDRMGSRSPVVVVMLLLAIPSLFVYSHSPSDKVLNAFVMTITGFFIGGPANLISSAISADLGRQPQL 339
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 424 RGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFFILMTSSTILFISPLI 483
Cdd:cd17342 340 RGSSEALATVTGIIDGTGSIGAAIGQVLVPLIQNRLGWMWVFYFFIIMTILTIVCILPLL 399
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
24-483 |
1.42e-96 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 296.49 E-value: 1.42e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 24 HIVVFLLTFFSYSLLHASRKTFSNVKVSISSqwtpsclnsttfelrpnelwnsnhlfpNAEEATLFLGTLDTIFLFSYAV 103
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVE---------------------------EIGLSKDDLGIIGSAFLIAYAV 53
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 104 GLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEwlhfynKWFYCCLWVVNGLLQSTGWPCVVAVMGNWFGKAGRGF 183
Cdd:cd17312 54 GKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTS------LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGT 127
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 184 VFGLWSACASVGNILGAFLA-SCVLKYGYEYAFLVTASVQFAGGVIVFCGLLTSPkevglpelgadeegsveedanrplm 262
Cdd:cd17312 128 VYGIWSTSHNFGGILAPILAaSLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP------------------------- 182
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 263 gdddadddegnysiqaadtdsqpkaigffqacclPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADQLSIWY 342
Cdd:cd17312 183 ----------------------------------PYVWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLY 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 343 DVGGIIGGTIQGLISDVL--QKRAPVLAISLLFAVGSLFGYSRSPNSKPINAVIMAITGFFIGGPSNMISSAISADLGRQ 420
Cdd:cd17312 229 EVGGIAGTILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRK 308
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 971371854 421 dlvrgssEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFFILMTSSTILFISPLI 483
Cdd:cd17312 309 -------EAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
25-486 |
1.57e-96 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 297.69 E-value: 1.57e-96
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 25 IVVFLLTFFSYSLLHASRKTFSNVKvsisSQWTPSCLNSTTFELR--PNELWNSNHLFpNAEEATLFLGTLDTIFLFSYA 102
Cdd:cd17344 2 GFILVLTFLAYACYHLSRKPISIVK----SVLHPNCSALIPPPNIvlNNTTWCGWAPF-DGKNGTELLGALDSAFLFAYA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 103 VGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGtLTEWLHFYNKWFYCCLWVVNGLLQSTGWPCVVAVMGNWFGKAGRG 182
Cdd:cd17344 77 IGMFFSGHIGERLPLRYFLSFGMLLSGLFTALFG-LGYYWNIHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 183 FVFGLWSACASVGNILGAFLASCVLKYGYEYAFLVTASVQFAGGVIVFCGLLTSPkevglpelgadeegsveedanrplm 262
Cdd:cd17344 156 LIMGIWNSHTSVGNILGSLIAGIFVSSAWGLSFIVPGIIIAAMGVLVFLFLVEHP------------------------- 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 263 gdddadddegnysiqaadtdsqpkaigffqacclPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADQLSIWY 342
Cdd:cd17344 211 ----------------------------------PGVIEFSLCLFFAKLVSYTFLYWLPLYISNTAILSAKKAGDLSTLF 256
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 343 DVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYSR-SPNSKPINAVIMAITGFFIGGPSNMISSAISADLGRQD 421
Cdd:cd17344 257 DVGGIVGGILAGYISDYTGGRATTCAAMLILAAPMLFIYNYfGQVSMTTNIVLLIVCGLLVNGPYALITTAVSADLGTHK 336
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971371854 422 LVRGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQeNLGWMWVFYFFILMTSSTILFISPLIVRE 486
Cdd:cd17344 337 SLKGNARALATVTAIIDGTGSIGAALGPLLAGLIS-SRGWNNVFYMLIAADVCAGLLLTRLVYKE 400
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
90-482 |
1.79e-28 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 116.96 E-value: 1.79e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEwlHFYNKWFYCCLWVVNGLLQSTGWPCVV 169
Cdd:cd17345 40 IGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPS--ATSSVGLMFILLFLNGWFQGMGWPPSG 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGN----ILGAFLASCVLKYGYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLPel 245
Cdd:cd17345 118 RTMVHWFSKKERGTWTSIWNISHNVGGglvgPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLP-- 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 246 gadeegSVEEDANRPlmgdddadddEGNYSIQAADTDSQPKAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLS 325
Cdd:cd17345 196 ------PIEEYKGDY----------PEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYLS 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 326 NNFGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQK--RAPVLAISLLFAVGSLFGYSRSPNSKPINaVIMAITGFFIG 403
Cdd:cd17345 260 EVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKgrRAPTGIIFMILVIVALIVYWLAPNVLVDL-IALIALGFLIY 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 404 GPSNMIS-SAIsadlgrqDLVrgSSEALATVTGIVDGTGSI-GAAVGQYLVSLIQENLGWMWVFYFFILMTSSTILFISP 481
Cdd:cd17345 339 GPVMLIGlQAL-------ELV--PKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGWNGGFIVLLASCILAIIFLAL 409
|
.
gi 971371854 482 L 482
Cdd:cd17345 410 V 410
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
90-471 |
8.41e-28 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 114.20 E-value: 8.41e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHFYnkwfycCLWVVNGLLQSTGWPCVV 169
Cdd:COG2271 47 LGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLL------LLRFLLGLGEAGFFPAAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGAFLAS-CVLKYGYEYAFLVTASVQFAGGVIVFcglltspkevglpelgad 248
Cdd:COG2271 121 KLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGwLLAAFGWRAAFLILGLPGLLLALLRF------------------ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 eegsveedanrplmgdddadddegnysiqaadtdsqpkaigffqacclpgvVLYSLAYACLKLVNYSFFFWLPFYLSNNF 328
Cdd:COG2271 183 ---------------------------------------------------WLLALAYFLVYFALYGFLTWLPTYLVEVR 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKR-APVLAISLLFAVGSLFGYSRSPNSkPINAVIMAITGFFIGGPSN 407
Cdd:COG2271 212 GLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRrKLVLAIGLLLAALALLLLALLPSP-ALAIALLFLAGFGLGGAFG 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 971371854 408 MISSAISADLGRqdlvrgssEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFFILM 471
Cdd:COG2271 291 LLWALAAELFPK--------KARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAAL 346
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
90-461 |
7.32e-25 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 105.92 E-value: 7.32e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWlhfynkWFYCCLWVVNGLLQSTGWPCVV 169
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL------WVMAALWALNGIFQGMGWPPCG 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGA--FLASCVLKYGYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLPELGA 247
Cdd:TIGR00881 106 RTVTKWFSRSERGTWVSFWNCSHNVGGGLLPplVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 248 DEEGSVEEDAnrplmgdddadddegnysiQAADTDSQPKAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLSNN 327
Cdd:TIGR00881 186 MPNEEPDGDA-------------------EKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQE 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 328 FGWKEAEADQLSIWYDVGGIIGGTIQGLISDVL--QKRAPVLAISLLFAVGSLFGYSRSP-NSKPINAVIMAITGFFIGG 404
Cdd:TIGR00881 247 KGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIVSLLVYWLNPaANPLMDLICLFALGFLVYG 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 971371854 405 PSNMISSAISAdlgrqdlvRGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGW 461
Cdd:TIGR00881 327 PQMLIGVIASE--------LAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGW 375
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
90-483 |
1.76e-19 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 90.54 E-value: 1.76e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTewlhfyNKWFYCCLWVVNGLLQSTGWPCVV 169
Cdd:PRK11663 60 IGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIATGIINILFGFSS------SLWAFALLWVLNAFFQGWGWPVCA 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCV-LKYGYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLPELGAD 248
Cdd:PRK11663 134 KLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGAIaLHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEW 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 EEGSVEedanrplmgdddadddegnYSIQAADTDSQPKAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNF 328
Cdd:PRK11663 214 RHDALE-------------------LAQQQEGAGLSRKEILTKYVLLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETL 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVL--QKRAP---VLAISLLFAVGSLfgYSRSPNSKPINAVIMAITGFFIG 403
Cdd:PRK11663 275 GVDLVTANSAVSMFELGGFIGALVAGWGSDKLfnGNRGPmnlIFAAGILLSVGSL--WLMPFASYVMQAACFFTIGFFVF 352
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 404 GPSNMISSAiSADLGRQDlvrgsseALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFFILMTSSTILFISPLI 483
Cdd:PRK11663 353 GPQMLIGMA-AAECSHKE-------AAGAATGFVGLFAYLGAALSGYPLAKVLEIWHWTGFFVVISIAAGISALLLLPFL 424
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
90-483 |
1.82e-18 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 86.69 E-value: 1.82e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHFYnkwfycCLWVVNGLLQSTGWPCVV 169
Cdd:cd17488 40 IGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGIINILFGFSSSLWAFA------VLWTLNAFFQGWGWPPCA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCV-LKYGYEYAFLVtasvqfAGGVIVFCGLLTSpkevglpelgad 248
Cdd:cd17488 114 RLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAaLTYGWRAGMYV------PGIIAILMGIVLC------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 eegsveedanrplmgdddadddegnYSIQaadtdSQPKAIGFFQACclpgvvlYSLAYACLKLVNYsfffWLPFYLSNNF 328
Cdd:cd17488 176 -------------------------WRLR-----DRPPYIWLLAFC-------YVLVYVVRTAIND----WGNLYLSETH 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQK--RAP---VLAISLLFAVGSLFgYSRSpNSKPINAVIMAITGFFIG 403
Cdd:cd17488 215 GYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKgnRGPmnlIFALGLLVSVGALW-LVPV-HSYWLLATCFFTIGFFVF 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 404 GPSNMISSAiSADLGRQDlvrgsseALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFFILMTSSTILFISPLI 483
Cdd:cd17488 293 GPQMLIGMA-AAECSHKD-------AAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAAAISGLLLLPLL 364
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
90-448 |
1.87e-16 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 80.54 E-value: 1.87e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWlhfynkWFYCCLWVVNGLLQSTGWPCVV 169
Cdd:pfam07690 34 IGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL------WLLLVLRVLQGLGAGALFPAAL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGAFLAS-CVLKYGYEYAFLVTASVQFAGGVIVFcgLLTSPKEVGLPELGAD 248
Cdd:pfam07690 108 ALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGlLASLFGWRAAFLILAILSLLAAVLLL--LPRPPPESKRPKPAEE 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 EEGSveedanrplmgdddadddegnysiqaadtdsqpkAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLsNNF 328
Cdd:pfam07690 186 ARLS----------------------------------LIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVL 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSL-FGYSRSPNSKPINAVIMAITGFFIGGPSN 407
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALgLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 971371854 408 MISSAISADLGRqdlvrgssEALATVTGIVDGTGSIGAAVG 448
Cdd:pfam07690 311 ALNALVSDLAPK--------EERGTASGLYNTAGSLGGALG 343
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
90-472 |
9.46e-16 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 78.77 E-value: 9.46e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHFYnkwfycCLWVVNGLLQSTGWPCVV 169
Cdd:cd17319 40 YGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLY------VLRFLLGVAEAGFFPGAI 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGA-FLASCVLKYGYEYAFLVTASVQFAGGVIVFCGLltspkevglpelgad 248
Cdd:cd17319 114 KALAEWFPARERGRATGLFNSGAPLGAAIGPpLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL--------------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 eegsveedanrplmgdddadddegnysiqaadtdsqpkaigffqacclPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNF 328
Cdd:cd17319 179 ------------------------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQAR 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYSRSPNSKPINAVI-MAITGFFIGGPSN 407
Cdd:cd17319 211 GFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVIlLSLAGFGIGAASP 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971371854 408 MISSaISADLgrqdlvrGSSEALATVTGIVDGTGSIGAAVGQYLVS-LIQENLGWMWVFYFFILMT 472
Cdd:cd17319 291 VFWS-LPADL-------LPGEAAATAGGLINSGGNLGGFVAPLLIGyLVDATGSYTAAFLFLAAVA 348
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
87-471 |
1.31e-14 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 75.16 E-value: 1.31e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 87 TLFLGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWlhfynkWFYCCLWVVNGLLQSTGWP 166
Cdd:cd06174 30 ASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF------WLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 167 CVVAVMGNWFGKAGRGFVFGLWSACASVGNILGAFLAScVLKYGYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLPELG 246
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG-ILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 247 ADEEGSveedanrplmgdddadddegnysiqaadtdSQPKAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLSN 326
Cdd:cd06174 183 KNEEAS------------------------------SKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 327 NFGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYSRSPNSKPInAVIMAITGFFIGGPS 406
Cdd:cd06174 233 LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLL-LLLLLLLGFGLGGLL 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971371854 407 NMISSAISadlgrqdlVRGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQ-ENLGWMWVFYFFILM 471
Cdd:cd06174 312 PLSFALIA--------ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLaATFGLTGAFLVLAVL 369
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
26-476 |
2.04e-14 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 75.06 E-value: 2.04e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 26 VVFLLTFFSYSLLHASRKTFSNVkvsissqwTPSCLNSTTfeLRPNELwnsnhlfpnaeeatlflGTLDTIFLFSYAVGL 105
Cdd:cd17343 3 TIFASMFVGYTLYYFNRKSFSFV--------LPSLMNELG--LDKSDL-----------------GLITSSQSLAYAISK 55
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 106 FVSGIVGDRLNLRWVLSFGMCSSALVVFFFGtltewlHFYNKWFYCCLWVVNGLLQSTGWPCVVAVMGNWFGKAGRGFVF 185
Cdd:cd17343 56 FIGGVLSDQISARWLFSSGLVLSGLTTVAFS------GSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWW 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 186 GLWSACASVGNILGAFLA-SCVLKYGYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLPELGADEEGSveedanrplmgd 264
Cdd:cd17343 130 SVLSTSMNLAGSLGPILAtLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKG------------ 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 265 ddadddegnysiqaaDTDSQPKAIGFFQACCL-PGVVLYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADQLSIWYD 343
Cdd:cd17343 198 ---------------KKKKSPRGESTLKELLLsPFLWLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLE 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 344 VGGIIGGTIQGLISDVLQKRAP---------VLAISLLFAVGSLFGYSRSPNSKPINAVIMAITGFFIG----GPSNMis 410
Cdd:cd17343 263 VGGFVGSIAAGYLSDWAVAKHGsssrgnprmPLALVFMAGLTVSLHLFRVHITSDSSELFILLLGFLIGfslyGPIAI-- 340
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971371854 411 SAISADLGRQDLVRGSSEAlatvtgIVDGTGSIGAAVGQYLVSLIQENLGWMWVfyFFILMTSSTI 476
Cdd:cd17343 341 FGVIANESAPSHLCGTSHA------IVALAANVGGVLAGLPFSYIAKHYDWRTA--FLLLEILCAI 398
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
90-427 |
3.09e-14 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 73.85 E-value: 3.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWlhfynkWFYCCLWVVNGLLQSTGWPCVV 169
Cdd:COG2814 47 AGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL------WLLLAARFLQGLGAGALFPAAL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVLKY-GYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLPELGAd 248
Cdd:COG2814 121 ALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLfGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGS- 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 eegsveedanrplmgdddadddegnysiqaadtdsqpkaigFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNF 328
Cdd:COG2814 200 -----------------------------------------LRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRaPVLAISLLFAVGSLFGYSRSPNSkPINAVIMAITGFFIGGPSNM 408
Cdd:COG2814 239 GLSASAAGLLLALFGLGGVLGALLAGRLADRFGRR-RLLLIGLLLLALGLLLLALAGSL-WLLLLALFLLGFGFGLLFPL 316
|
330
....*....|....*....
gi 971371854 409 ISSAISADLGRQDLVRGSS 427
Cdd:COG2814 317 LQALVAELAPPEARGRASG 335
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
90-486 |
4.35e-14 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 73.76 E-value: 4.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHFYnkwFYCCLWvvnGLLQSTGWPCVV 169
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLL---LLGLLL---GIGGGGSFAVGI 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVLK-YGYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLPElgad 248
Cdd:COG2223 116 ALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAaFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAA---- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 eegsveedanrplmgdddadddegnysiqaadtdsQPKAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNF 328
Cdd:COG2223 192 -----------------------------------KASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQF 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVLqKRAPVLAISLLFAVGSLFGYSRSPNSKPINAVIMAITGFFIGGPSNM 408
Cdd:COG2223 237 GLSAATAGLLAALFALLGALGRPLGGWLSDRI-GGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGA 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 971371854 409 ISSAISADLGRqdlvrgssEALATVTGIVDGTGSIGAAVGQYLVSLIQENLG-WMWVFYFFILMTSSTILFISPLIVRE 486
Cdd:COG2223 316 VFALVPDIFPT--------KNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRP 386
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
95-451 |
1.11e-13 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 72.67 E-value: 1.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 95 TIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLtewlhfYNKWFYCCLWVVNGLLQSTGWPCVVAVMGN 174
Cdd:cd17327 48 TVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAV------KNFGGLIALRFFLGLFESGVFPGFILYLGM 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 175 WFGKAGRGFVFGLWSACASVGNILGAFLASCVLK-------YGYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLpeLGA 247
Cdd:cd17327 122 WYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKilgvgglAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWF--LTE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 248 DEEGSVEE--DANRPLMGdddadddegnysiqaadtDSQPKAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLS 325
Cdd:cd17327 200 EEKELAVErlRANQTGKG------------------DQKFKWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILK 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 326 NNfGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFA-VGSLFGYSRSPNSKPINAVIMAITGFFIGG 404
Cdd:cd17327 262 SL-GFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLAlVGSIILLAAPNPPGAYFAAYILGGGSYAGF 340
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 971371854 405 PSNM--ISSAISADLGRqdlvrgssealATVTGIVDGTGSIGAAVGQYL 451
Cdd:cd17327 341 PILLswISSNCAGYTKR-----------ATVLAIMLIFYNVGNIVAPQI 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
88-479 |
4.18e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 67.60 E-value: 4.18e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 88 LFLGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWlhfynkWFYCCLWVVNGLLQSTGWPC 167
Cdd:cd17325 31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY------WQLLLARFLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 168 VVAVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVLK-YGYEYAFLVTASVQFAGGVIVfcgLLTSPKEVGLPELG 246
Cdd:cd17325 105 AMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADaLGYRAPFLVCAALALLALVLA---LLLLPEPRPPPNKR 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 247 ADEEGSVEEDANRPLMGdddadddegnysiqaadtdsqpkaigffqacclPGVVLYSLAYACLKLVNYSFFFWLPFYLSN 326
Cdd:cd17325 182 AVSAARLRSGLRLLLRD---------------------------------RRLLALFLAIFVLAFAFGALEPFLPLYAAE 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 327 NFGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRaPVLAISLLFAVGSLFGYSRSPnSKPINAVIMAITGFFIGgps 406
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRK-PLILIGLLLSAVALLLLPLAT-SFWLLLLLLALLGLGLG--- 303
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 971371854 407 nMISSAISADLGRqdlvRGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFF-ILMTSSTILFI 479
Cdd:cd17325 304 -LVFPATLALLAD----IVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAaALLLLAAVLFL 372
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
87-409 |
3.12e-10 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 62.37 E-value: 3.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 87 TLFLGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHfYNKWFYCCLWVVNGLLQSTGWP 166
Cdd:PRK09556 63 TTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGASLGSGS-VSLGLMIALWALSGFFQSTGGP 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 167 CVVAVMGNWFGKAGRGFVFGLWSACASVGNILGAFLAscvlkygyeyafLVTASVQFAGGVIvfcGLLTSPKEVGLP--- 243
Cdd:PRK09556 142 CSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVA------------LWGANYFFDGHVI---GMFIFPSIIALIigf 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 244 ---ELGADEE-----GSVEEDANRPlmgdddadddegnysIQAADTDSQPKAIGFFQACC---LPGVVLYSLAYA--CLK 310
Cdd:PRK09556 207 iglRYGSDSPeelgwGKAEEIFGEP---------------ISEEDKETESTDMTKWQIFVeyvLKNPVIWLLCFAniFLY 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 311 LVNYSFFFWLPFYLSNNFGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQ-KRAPVLAISLLFAVGSLFGYSRSPNSKP 389
Cdd:PRK09556 272 IVRIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLANgRRALVACIALALIIFTLGVYQHATSEYM 351
|
330 340
....*....|....*....|
gi 971371854 390 INAVIMAItGFFIGGPSNMI 409
Cdd:PRK09556 352 YLASLFAL-GFLVFGPQLLI 370
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
90-485 |
2.54e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.02 E-value: 2.54e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLhfynkWFYCCLWVV---NGLLQSTGWP 166
Cdd:COG0738 45 AGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP-----LLLLALFLLglgLGLLDVAANP 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 167 CVVAVmgnwfGKAGRGFVFGLWSACASVGNILGAFLASCVLKYGYE----YAFLVTASVQFAGGVIVFCglltspkeVGL 242
Cdd:COG0738 120 YVAAL-----GPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSlswhLPYLILAVLLLLLALLFLR--------SKL 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 243 PELGADEEgsveedanrplmgdddadddegnysiqaadtDSQPKAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPF 322
Cdd:COG0738 187 PEIEEEEE-------------------------------EAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 323 YLSNNFGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLqKRAPVLAISLLFAVGSLFGYSRSPNSkPINAVIMAITGFFI 402
Cdd:COG0738 236 YLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRF-GPVRLLRLSALLAAVGLLLALLAPGP-WLALIGLALVGLGL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 403 ggpSNMISSAISAdlgrqdLVRGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFFILMTsSTILFISPL 482
Cdd:COG0738 314 ---SLMFPTIFSL------ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCY-LLILLLALA 383
|
...
gi 971371854 483 IVR 485
Cdd:COG0738 384 LKR 386
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
90-483 |
3.02e-06 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 49.54 E-value: 3.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMcssalvvFFFGTLTEWLHFYNKWFYCCLW-VVNGLLQSTGWPCV 168
Cdd:cd17328 36 AGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGI-------LIWSAATLLSSFAPNFWQLLLFrALVGIGEASYSPIA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 169 VAVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCV--LKYGYEYAFLVTASVQFAGGVIVFCGlltspkeVGLPELG 246
Cdd:cd17328 109 PTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVaqATGGWRWAFRVTGVLGVLLAILLLLF-------VREPPRG 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 247 ADEEGSVEEDANRPLMGDDDADDDEgnysiqaadtdsqpkaigffqacclPGVVLYSLAYACLKLVNYSFFFWLPFYLSN 326
Cdd:cd17328 182 AAEGGVMAKSTATSFLADLKALAKN-------------------------PSFILSTLGFTAVSFVTGALAFWAPTFFLR 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 327 NFGWKEAEADQLSIWYDVGGIIG----GTIQGLISDVLQKRAP-----VLAISLLFAVGSLFGysrSPNSKPINAVIMAI 397
Cdd:cd17328 237 AFGVGDLSSADVGLIFGAITCIAgvlgVLLGGILADRLRRKTPradplVCAVGLLAAAPFLFL---ALVLALSNLLLAWV 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 398 TGFFIGGPSNMIsSAISADLGRQDLV---RGSSEALATVTgivdgTGSIGAAVGQYLVSLIQENLGWMWVFYFFILMTSS 474
Cdd:cd17328 314 LLFLGEFLLSLN-WAPVFAILLYVVIptrRSTASAIQILL-----SHLLGDAGSPYLIGLISDLLRQNKDSPLAEAASLQ 387
|
....*....
gi 971371854 475 TILFISPLI 483
Cdd:cd17328 388 YALLLCSFV 396
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
90-230 |
3.86e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.16 E-value: 3.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFffgtLTEWLHFYnkWFYCCLWVVNGLLQSTGWPCVV 169
Cdd:cd17475 33 VGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAAL----LMALVGSY--PVLLVLLFLVGAGYGSVQPGGG 106
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 971371854 170 -AVMGnWFGKAGRGFVFGLWSACASVGNILGA-FLASCVLKYGYEYAFLVTASVQFAGGVIVF 230
Cdd:cd17475 107 rAIMR-WFPPRERGLAMGIRQTGVPLGGALAAaLLPPLALHYGWRAAFVVAGLVSILAAVLFW 168
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
95-455 |
9.80e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 47.97 E-value: 9.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 95 TIFLFSYAVGLFVSGIVG---DRLNLRW-----VLSFGMCSSALVVFFFGTLTEWLHFYNKWFYCCLWVVNGLLQSTGWP 166
Cdd:COG2211 50 LILLVARLWDAITDPLIGalsDRTRTRWgrrrpWILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTYLLLGLAYTLVNI 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 167 CVVAVMGNWFGKAG-RGFVFGLWSACASVGNILGAFLASCVLKY-------GYEYAFLVTASVQFAGGVIVFCGLltspK 238
Cdd:COG2211 130 PYSALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaalGYRLTALIFAVLGLLAFLLTFFGT----K 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 239 EVGLPElgaDEEGSVEED-----ANRPLMgdddadddegnysiqaadtdsqpkaigffqacclpgvvLYSLAYACLKLVN 313
Cdd:COG2211 206 ERPVPE---EEKVSLKESlkallKNRPFL--------------------------------------LLLLAYLLFFLAL 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 314 YSFFFWLPFYLSNNFGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYSRSPNSKPINAV 393
Cdd:COG2211 245 ALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLV 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 971371854 394 IMAITGFFIGGPsNMISSAISADLGRQDLVRGSSEALATVTGIVDGTGSIGAAVGQYLVSLI 455
Cdd:COG2211 325 LAALAGIGLGAI-LVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
96-230 |
1.97e-05 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 46.84 E-value: 1.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 96 IFLFSYAVGLFVSGIVG----DRLNLRWVLSFGMCSSALVVFFFGTLTEWlhfynkWFYCCLWVVNGLLQSTGWPCVVAV 171
Cdd:cd17329 39 LVLALSAVAGIVASLIGgrlaDRFGRKPVMLAGLLLRALGFALLGFAHSP------WLFAIALVLTGFGGGLFEPASEAM 112
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 971371854 172 MGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVLKYGYEYAFLVTASVQFAGGVIVF 230
Cdd:cd17329 113 IADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFLLAALVLL 171
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
90-478 |
2.80e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.40 E-value: 2.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHFYnkwfycCLWVVNGLLQSTGWPCVV 169
Cdd:COG2807 55 AGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLL------AGTALIGAGIAVGNVLLP 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAgRGFVFGLWSACASVGNILGAFLASCVLK-YGYEYAFLVTASVQFAGGVIVFCGLLTSPKEvglpelgad 248
Cdd:COG2807 129 GLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAAaLGWRGALAVWALLALLALLLWLPLLRRRPAA--------- 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 eegsveedanrplmgdddadddegnysiqAADTDSQPKAIGFFQAcclPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNf 328
Cdd:COG2807 199 -----------------------------AAAAPAAASLRSLWRS---PLAWLLTLFFGLQSLLYYAVVAWLPPILRDA- 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYSRSPNSKPInaVIMAITGFFIGGPSNM 408
Cdd:COG2807 246 GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW--LWAVLLGLGQGGLFPL 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971371854 409 ISSAISadlgrqDLVRGSSEAlATVTGIVDGTGSIGAAVGQYLVSLIQENLG-WMWVFYFFILMTSSTILF 478
Cdd:COG2807 324 ALTLIG------LRARTPAEA-AALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVLMLVA 387
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
90-479 |
3.42e-05 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 46.18 E-value: 3.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHFYnkwfycCLWVVNGLLQSTGWPCVV 169
Cdd:TIGR00893 31 YGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAYVSLY------ILRVLLGAAEAPFFPGII 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNIL-GAFLASCVLKYGYEYAFLVTASVQFAGGVIVFCGLLTSPKEVGLpelgad 248
Cdd:TIGR00893 105 LIVASWFPASERATAVSIFNSAQGLGGIIgGPLVGWILIHFSWQWAFIIEGVLGIIWGVLWLKFIPDPPQKAKW------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 eegSVEEDANRPLMGDDDADDDEGNysiqaadtdSQPKAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNF 328
Cdd:TIGR00893 179 ---LTEEEKYIVVGGLLAEQQGKGP---------STPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQER 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYSRSP---NSKPINAVIMAIT--GFFIG 403
Cdd:TIGR00893 247 GLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMfatNYVNIPYAALALValGFFGL 326
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 404 GPSNMISSAISADLGRqdlvrgssEALATVTGIVDGTGSIGAAVGQYLVSLIQE-----NLGWMWVFYFFILMTSSTILF 478
Cdd:TIGR00893 327 GAGAIGWALISDNAPG--------NIAGLTGGLINSLGNLGGIVGPIVIGAIAAttgsfAGALMVVAALALIGALSYLLL 398
|
.
gi 971371854 479 I 479
Cdd:TIGR00893 399 V 399
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
87-230 |
4.33e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 45.62 E-value: 4.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 87 TLFLGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFgtltewLHFYNKWFYCCLWVVNGLLQSTGWP 166
Cdd:cd17478 229 LVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLF------LLTPGIWSYILLVLAGFLLFASFPV 302
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971371854 167 CVVAVMGNWFGKAG--RGFVFGLwsaCASVGNILGAFLASCVLKYGYEYAFLVTASVQFAGGVIVF 230
Cdd:cd17478 303 TVVLAQELLPGNVGlaSGLMMGL---SFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
89-220 |
5.79e-05 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 45.24 E-value: 5.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 89 FLGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFffgtLTEWLHFYNKWFYCCLWVVNGLLQSTGWPCV 168
Cdd:cd17380 35 DQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATL----LTPLLAYSSLPLLILSRILLGLGEGVHFPSM 110
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 971371854 169 VAVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVL-KYGYEYAFLVTAS 220
Cdd:cd17380 111 TSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLeYYGWPSVFYFFGL 163
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
90-230 |
1.11e-04 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 44.03 E-value: 1.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 90 LGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTewlhfyNKWFYCCLWVVNGLLQSTGWPCVV 169
Cdd:COG0477 51 LGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAP------SPELLIAARALQGIGAGGLMPGAL 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVLKY-GYEYAFLVTASVQFAGGVIVF 230
Cdd:COG0477 125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAlGWRWIFLINAPLGLLALVLRL 186
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
95-230 |
1.86e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.71 E-value: 1.86e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 95 TIFLFSYAVGLFVSGIVGDRLN--LRWVLSFGMCSSALVVFFFGTLTewlhfyNKWFYCCLWVVNGLLQSTGWPCVVAVM 172
Cdd:COG2271 223 SLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLLLALLP------SPALAIALLFLAGFGLGGAFGLLWALA 296
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 971371854 173 GNWFGKAGRGFVFGLWSACASVGNILGAFLASCVL-KYGYEYAFLVTASVQFAGGVIVF 230
Cdd:COG2271 297 AELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLdATGYQAAFLLLAALALLAALLAL 355
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
89-230 |
3.85e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.97 E-value: 3.85e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 89 FLGTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGtlteWLHFYNKWFYCCLWVVNGLLQSTGWPCV 168
Cdd:COG2211 265 LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLF----FLGPGNLWLLLVLAALAGIGLGAILVLP 340
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 169 VAVM------GNW-FGKAGRGFVFGLWSACASVGNILGAFLASCVLK-YGYEYAFLVTASVQFAGGVIVF 230
Cdd:COG2211 341 WAMLadvvdyDEWkTGRRREGLYFGIFTFAIKLGQALAGALAGLLLAlFGYVAGAAQSPSALTGIRLLFF 410
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
95-234 |
4.06e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 42.60 E-value: 4.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 95 TIFLFSYAVGLFVSGIVGDRLNLRWVLSFG--MCSSALVVFFFGTltewlhfYNKWFYCCLWVVNGLLQSTGWPCVVAVM 172
Cdd:cd17353 45 TLTIVFLAISAPFAGRLVDRGGPRKAILIGgiLFGLGFILSAFAI-------SLPLLFLGYGVLGGIGAGIGYITPVSTA 117
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 971371854 173 GNWFgKAGRGFVFGLWSACASVGNILGAFLASCVLK-YGYEYAFLVTASVQFAggVIVFCGLL 234
Cdd:cd17353 118 VKWF-PDKRGLATGIVIAGFGLGSLIFSPLIAYLINtVGVPTTFLILGIIFLI--IIVIGAFL 177
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
96-230 |
4.26e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 42.60 E-value: 4.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 96 IFLFSYAVGLFVSGIV----GDRLNLRWVLSFGMCSSALVVFFFGTLTEWlhfynkWFYCCLWVVNGLLQSTGWPCVVAV 171
Cdd:cd06173 248 LLLAAFGVGALLGALLlgrlSKRRRRGRLLLIGALLLGLALLVLGLSPSL------WLLLAALFLLGLAGGLFNVPLNTL 321
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 172 MGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVL-KYGYEYAFLVTASVQFAGGVIVF 230
Cdd:cd06173 322 LQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAdALGLSAVFLLAGALLLLAALLLL 381
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
97-221 |
6.04e-04 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 42.22 E-value: 6.04e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 97 FLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFffgtLTEWLHFYNKWFYCCLWVVNGLLQSTGWPCVVAVMGNWF 176
Cdd:cd17318 65 FFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTL----LTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWA 140
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 971371854 177 GKAGRGFVFGLWSACASVGNI----LGAFLAScvlKYGYEYAFLVTASV 221
Cdd:cd17318 141 PPLERSRLTSIAYSGSQFGTViampLSGFLCE---SLGWPSIFYIFGGL 186
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
91-198 |
7.60e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.88 E-value: 7.60e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 91 GTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWlhfynkWFYCCLWVVNGLLQSTGWPCVVA 170
Cdd:COG2814 246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL------WLLLLALFLLGFGFGLLFPLLQA 319
|
90 100
....*....|....*....|....*...
gi 971371854 171 VMGNWFGKAGRGFVFGLWSACASVGNIL 198
Cdd:COG2814 320 LVAELAPPEARGRASGLYNSAFFLGGPL 347
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
91-472 |
1.22e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 41.00 E-value: 1.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 91 GTLDTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMcssalVVFFFGTLTEWlhFYNKWFYCCLW-VVNGLLQSTGWPCVV 169
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLL-----LLFILGNLLAA--LAPSFALLLLArALAGLAHGGFWAIAA 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 170 AVMGNWFGKAGRGFVFGLWSACASVGNILGAFLASCVLKY-GYEYAFLVTASVQFAGGVIVFcglltspkeVGLPELGAD 248
Cdd:cd17324 110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlGWRAAFLAIAVLALLAALLLW---------RLLPSLPPK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 249 EEGSveedanrplmgdddadddegnysiqaadtdsQPKAIGFFQACCLPGVVLYSLAYACLKLVNYSFFFWLPFYLSNNF 328
Cdd:cd17324 181 KPGS-------------------------------LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 329 GWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYSrsPNSKPINAVIMAITGFFIGGPSNM 408
Cdd:cd17324 230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLL--GPSPLLLLVGLVLWGLGFFAAHSA 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 971371854 409 ISSAISadlgrqdlvRGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWMWVFYFFILMT 472
Cdd:cd17324 308 LQTRVL---------RLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALL 362
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
95-230 |
2.14e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 2.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 95 TIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTEWLHFynkWFYCCLW-VVNGLLQSTGwPCVVAVMG 173
Cdd:cd17370 241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLL---LLGFILWgLYMGAQESIE-RAAVADLV 316
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 971371854 174 nwfGKAGRGFVFGLWSACASVGNILGAFLASCVL-KYGYEYAFLVTASVQFAGGVIVF 230
Cdd:cd17370 317 ---PAELRGTAYGLFNTVVGIGWLLASLIAGYLWdLISPSAAFLFSAVLALIALLLLL 371
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
82-238 |
3.95e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.45 E-value: 3.95e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 82 NAEEATLFLgtldTIFLFSYAVGLFVSGIVGDRLNLRWVLSFGMCSSALVVFFFGTLTewlhfyNKWFYCCLWVVNGLLQ 161
Cdd:COG0738 244 SEATAALGL----SLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP------GPWLALIGLALVGLGL 313
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 971371854 162 STGWPCVVAVMGNWFGKAGrGFVFGLWSACASVGNILGAFLASCVL-KYGYEYAFLVTAsvqFAGGVIVFCGLLTSPK 238
Cdd:COG0738 314 SLMFPTIFSLALDGLGKRT-AAAVSAVLIMGIVGGAIGPPLIGFLAdAFGLRAAFLVPL---VCYLLILLLALALKRK 387
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
299-480 |
5.99e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 38.74 E-value: 5.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 299 VVLYSLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRaPVLAISLLFAVGSL 378
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRK-KTLVIGLILSGILA 257
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 379 FGYSRSPNSKPINAVIMAITGFFIGGPSNMISSAISADLgrqdlvrGSSEALATVTGIVDGTGSIGAAVGQYLVSLIQEN 458
Cdd:cd17316 258 LPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAEL-------FPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
|
170 180
....*....|....*....|..
gi 971371854 459 LGWMWVFYFFILMTSSTILFIS 480
Cdd:cd17316 331 TGGTGVPALILALLAIVALIVA 352
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
303-472 |
7.67e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.55 E-value: 7.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 303 SLAYACLKLVNYSFFFWLPFYLSNNFGWKEAEADQLSIWYDVGGIIGGTIQGLISDVLQKRAPVLAISLLFAVGSLFGYS 382
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971371854 383 RSPNskPINAVIMAITGFFIGGPSNMISSAISADLGRqdlvrgssEALATVTGIVDGTGSIGAAVGQYLVSLIQENLGWM 462
Cdd:pfam07690 82 ASSL--WLLLVLRVLQGLGAGALFPAALALIADWFPP--------EERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170
....*....|
gi 971371854 463 WVFYFFILMT 472
Cdd:pfam07690 152 AAFLILAILS 161
|
|
| |
