|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
321-1115 |
8.47e-175 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 535.53 E-value: 8.47e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 321 PQPNYGGAYPGTPNYGSQPGPppkrldpdSIPS-PIQVIEDdrnnrgSEPFVTGVRG----QVPPLvTTNFLVKDQGNAS 395
Cdd:COG5028 85 SQQKFSSPYGGSMADGTAPKP--------TNPLvPVDLFED------QPPPISDLFLppppIVPPL-TTNFVGSEQSNCS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 396 PRYIRCTSYNIPCTSDMAKQSQVPLAAVIKPLATLPPEETLPYLVDHGEsgPVRCNRCKAYMCPFMQFIEGGRRFQCCFC 475
Cdd:COG5028 150 PKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNIC 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 476 SCVTEVPAHYFQHLDHTGKRVDFYDRPELSLGSYEFLATVDYckNNKFPSPPAFIFMIDVSYNAVKSGLVRLICEELKSI 555
Cdd:COG5028 228 RSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEY--SLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILEN 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 556 LDYLPregNMEESAiRVGFVTYNKVLHFYNVKSSLaQPQMMVVSDVADMFVPLLDG-FLVNVNESRTVITSLLDQIPEMF 634
Cdd:COG5028 306 LDQIP---NFDPRT-KIAIICFDSSLHFFKLSPDL-DEQMLIVSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIF 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 635 ADTRETETVFGPviqagleALKAA-----ECAGKLFIFHTSLPIAeAPGKLKNRDDKklintdkEKTLFQPQTSFYSNLA 709
Cdd:COG5028 381 QDNKSPKNALGP-------ALKAAksligGTGGKIIVFLSTLPNM-GIGKLQLREDK-------ESSLLSCKDSFYKEFA 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 710 KDCVAQGCCVDLFLFPNQYLDVATLGVVTYQTGGSIYKYAYFQLE--ADQDRFLNDLRRDVQKEVGFDAVMRVRTSTGIR 787
Cdd:COG5028 446 IECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSATrpNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLR 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 788 ATDFFGAFYMSNTTDVEMAGLDCDKTITVEFKHDDKLSeDSGALLQCALLYTSCAGQRRLRIHNLSLNCCTQLADLYRNC 867
Cdd:COG5028 526 VSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASA 604
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 868 ETDTLINYLAKYAYRGVLNSPVKSVRDSLINQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGpE 947
Cdd:COG5028 605 DQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSG-S 683
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 948 VTTDDRAYIRQLVTSMDVAETNVFFYPRLLPLTKADVDSDS-------LPAAIRNSEERLSKGDIYLLENGLNIFVWVGV 1020
Cdd:COG5028 684 TPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAGLpdegllvLPSPINATSSLLESGGLYLIDTGQKIFLWFGK 763
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 1021 NVQQGLIQNLFGVSSFSQISSTLSTLPVLENPFSKKVRSIIDMLHLQ-RSRYMKLIIVKQ--EDKLEMLFKHFLVEDKSL 1097
Cdd:COG5028 764 DAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVnDDSTLPLVLVRGggDPSLRLWFFSTLVEDKTL 843
|
810
....*....|....*...
gi 971402013 1098 tGGASYVDFLCHMHKEIR 1115
Cdd:COG5028 844 -NIPSYLDYLQILHEKIK 860
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
524-772 |
1.40e-121 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 373.53 E-value: 1.40e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 524 PSPPAFIFMIDVSYNAVKSGLVRLICEELKSILDYLPREgnmeESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 603
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGD----DPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 604 MFVPLLDGFLVNVNESRTVITSLLDQIPEMFADTRETETVFGPVIQAGLEALKaaECAGKLFIFHTSLPIAEApGKLKNR 683
Cdd:cd01479 77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 684 DDKKLINTDKEKTLFQPQTSFYSNLAKDCVAQGCCVDLFLFPNQYLDVATLGVVTYQTGGSIYKYA--YFQLEADQDRFL 761
Cdd:cd01479 154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPsfNFSAPNDVEKLV 233
|
250
....*....|.
gi 971402013 762 NDLRRDVQKEV 772
Cdd:cd01479 234 NELARYLTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
524-768 |
6.62e-115 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 355.79 E-value: 6.62e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 524 PSPPAFIFMIDVSYNAVKSGLVRLICEELKSILDYLPREGNMeesaiRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 603
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRA-----RVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 604 MFVPLLDGFLVNVNESRTVITSLLDQIPEMFADTRETETVFGPVIQAGLEALKAAECAGKLFIFHTSLPIAEAPGKLKNR 683
Cdd:pfam04811 76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 684 DDKKLINTDKEKTLFQPQT-SFYSNLAKDCVAQGCCVDLFLFPNQYLDVATLGVVTYQTGGSIYKYAYFQLEADQDRFLN 762
Cdd:pfam04811 156 LDESHHGTDKEKAKLVKKAdKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235
|
....*.
gi 971402013 763 DLRRDV 768
Cdd:pfam04811 236 DLQRYF 241
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
522-1116 |
1.73e-49 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 192.60 E-value: 1.73e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 522 KFPS-----PPAFIFMIDVSYNAVKSGLVRLICEELKSILDylpregNMEESAIRVGFVTYNKVLHFYNVKSSLAQP--- 593
Cdd:PTZ00395 943 KYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIRYAVQ------NVKCPQTKIAIITFNSSIYFYHCKGGKGVSgee 1016
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 594 ----------QMMVVSDVADMFVPL-LDGFLVNVNESRTVITSLLDQIPEMFADTRETETVFGPVIQAGLEALKAAECAG 662
Cdd:PTZ00395 1017 gdggggsgnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGLG 1096
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 663 KLFIFHTSLPIAeAPGKLKnrddkKLINTDKEKTLFQPQTSFYSNLAKDCVAQGCCVDLFLFP--NQYLDVATLGVVTYQ 740
Cdd:PTZ00395 1097 SICMFYTTTPNC-GIGAIK-----ELKKDLQENFLEVKQKIFYDSLLLDLYAFNISVDIFIISsnNVRVCVPSLQYVAQN 1170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 741 TGGSIYKYAYFQLEAD-QDRFLNDLRRDVQKEVGFDAVMRVRTSTGIRATDFFGAFYMSNTT----DVEMAGLDCDKTIT 815
Cdd:PTZ00395 1171 TGGKILFVENFLWQKDyKEIYMNIMDTLTSEDIAYCCELKLRYSHHMSVKKLFCCNNNFNSIisvdTIKIPKIRHDQTFA 1250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 816 VEFKHDDKLSEDSGALLQCALLYTSCAGQRRLRIHNLSLNCCTQLADLYRNCETDTLINYLAKYAYRGVLNSPVKSvrDS 895
Cdd:PTZ00395 1251 FLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHNDNYS--KI 1328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 896 LINQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQpgPEVTTDDRAYIRQLVTSMDVAETNVFFYP- 974
Cdd:PTZ00395 1329 IIDNLAAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNVTK--KEILHDLKVYSLIKLLSMPIISSLLYVYPv 1406
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 975 --------RLLPLTKADVDSD-SLPAAIRNSEERLSKGDIYLLENGLNIFVWVGVNVQQGLIQNLFGVSSFSQISSTLSt 1045
Cdd:PTZ00395 1407 myvihikgKTNEIDSMDVDDDlFIPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVGDIPTEKNAHELN- 1485
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971402013 1046 lpVLENPFSKKVRSIIDML----HLqrSRYMKLIIVKQEDKLEMLFKHFLVEDKSlTGGASYVDFLCHMHKEIRQ 1116
Cdd:PTZ00395 1486 --LTDTPNAQKVQRIIKNLsrihHF--NKYVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCFIHKLVHK 1555
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
3-281 |
3.26e-13 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 74.42 E-value: 3.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 3 VNQHTHAGPPygqPQPGYQGYQQPAYGGqPLPGVPHT-QYGAYNGPMPGYQQPVPP-----QGSVRALPTSGAPPPASGT 76
Cdd:pfam03154 249 LQPMTQPPPP---SQVSPQPLPQPSLHG-QMPPMPHSlQTGPSHMQHPVPPQPFPLtpqssQSQVPPGPSPAAPGQSQQR 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 77 SLPSGHQGYSQFGQGDVQNGIPTSTAPMQ--RPPASQPFLPGSA------PAPVSQPSTFQQYG--PPPCSVQQLSNHMa 146
Cdd:pfam03154 325 IHTPPSQSQLQSQQPPREQPLPPAPLSMPhiKPPPTTPIPQLPNpqshkhPPHLSGPSPFQMNSnlPPPPALKPLSSLS- 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 147 gmTIGSTSVSAPP----PAGLGYGPPTSVPPV---SGSFSATGSGLYTPYTASPGPpppsvpqglplAQPPFSGQPVPTQ 219
Cdd:pfam03154 404 --THHPPSAHPPPlqlmPQSQQLPPPPAQPPVltqSQSLPPPAASHPPTSGLHQVP-----------SQSPFPQHPFVPG 470
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971402013 220 RLPTEVPGFAPPPPA----TGIGASSYPPPTGAPRPPPMPGPPLSGQTVAGPPMSQPNHVSSPPPP 281
Cdd:pfam03154 471 GPPPITPPSGPPTSTssamPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPP 536
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
46-380 |
3.15e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.96 E-value: 3.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 46 GPMPGYQQPVPPQGSvralPTSGAPPPASGTSLPSGHQGYSQFGQgdvqngiPTSTAPMQRPPASQPFLPGSAPAPVSQP 125
Cdd:PHA03247 2693 GSLTSLADPPPPPPT----PEPAPHALVSATPLPPGPAAARQASP-------ALPAAPAPPAVPAGPATPGGPARPARPP 2761
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 126 STfqqYGPPpcsvqqlsnhmagmtigstsvSAPPPAGLGYGPP--TSVPPVSGSFSATGSGLYTPYTASPGPPPPSVPQG 203
Cdd:PHA03247 2762 TT---AGPP---------------------APAPPAAPAAGPPrrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 204 LPLAQPPFSGQPVPTQRLPTEVPGFAPPPPATGIGASSYPPPTGAPRPPPMPGPPLSGQTVAGPPMSQPNHVSSPPPPLT 283
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES 2897
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 284 LSGPHPGPPMSGPPPPTHPPQPGYQMQQNgsfgqvrgPQPNyggayPGTPNYGSQPGPPPKRLDPDSIPSPIQVIEDDRN 363
Cdd:PHA03247 2898 FALPPDQPERPPQPQAPPPPQPQPQPPPP--------PQPQ-----PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL 2964
|
330
....*....|....*..
gi 971402013 364 NRGSEPFVTGVRGQVPP 380
Cdd:PHA03247 2965 GALVPGRVAVPRFRVPQ 2981
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
2-148 |
1.44e-04 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 45.95 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 2 SVNQHTHAGPPYGQPQPGYQgyqqpaYGGQPLpGVPHTQygayngPMPGYQQPVPPQGsvralPTSGAPPPASGTSlpsg 81
Cdd:TIGR01628 389 SPMGGAMGQPPYYGQGPQQQ------FNGQPL-GWPRMS------MMPTPMGPGGPLR-----PNGLAPMNAVRAP---- 446
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 971402013 82 hqgysqfGQGDVQNGIPTSTAPMQRPPASQPfLPGSAPAPVSQPSTFQQyGPPPCSVQQLSNHMAGM 148
Cdd:TIGR01628 447 -------SRNAQNAAQKPPMQPVMYPPNYQS-LPLSQDLPQPQSTASQG-GQNKKLAQVLASATPQM 504
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
63-285 |
7.42e-03 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 39.88 E-value: 7.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 63 ALPTSGAPPPASGTslPSGHQGYSQFG--QGDVQNGIPTSTAPMQRPPASQPFLPGSAPAPVSqpstfqqygPPPCSVQQ 140
Cdd:COG5651 163 ALTPFTQPPPTITN--PGGLLGAQNAGsgNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLN---------SGPGNTGF 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 141 LSNHMAGMTIGSTSVSAPPPAGLGYGPPTSVPPVSGSFSATGSGLYTPYTASPGPPPPSVPQGLPLAQPPFSGQPVPTQR 220
Cdd:COG5651 232 AGTGAAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLG 311
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971402013 221 LPTEVPGFAPPPPATGIGASSYPPPTGAPRPPPMPGPPLSGQTVAGPPMSQPNHVSSPPPPLTLS 285
Cdd:COG5651 312 AGGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAG 376
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| COG5028 |
COG5028 |
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking ... |
321-1115 |
8.47e-175 |
|
Vesicle coat complex COPII, subunit SEC24/subunit SFB2/subunit SFB3 [Intracellular trafficking and secretion];
Pssm-ID: 227361 [Multi-domain] Cd Length: 861 Bit Score: 535.53 E-value: 8.47e-175
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 321 PQPNYGGAYPGTPNYGSQPGPppkrldpdSIPS-PIQVIEDdrnnrgSEPFVTGVRG----QVPPLvTTNFLVKDQGNAS 395
Cdd:COG5028 85 SQQKFSSPYGGSMADGTAPKP--------TNPLvPVDLFED------QPPPISDLFLppppIVPPL-TTNFVGSEQSNCS 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 396 PRYIRCTSYNIPCTSDMAKQSQVPLAAVIKPLATLPPEETLPYLVDHGEsgPVRCNRCKAYMCPFMQFIEGGRRFQCCFC 475
Cdd:COG5028 150 PKYVRSTMYAIPETNDLLKKSKIPFGLVIRPFLELYPEEDPVPLVEDGS--IVRCRRCRSYINPFVQFIEQGRKWRCNIC 227
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 476 SCVTEVPAHYFQHLDHTGKRVDFYDRPELSLGSYEFLATVDYckNNKFPSPPAFIFMIDVSYNAVKSGLVRLICEELKSI 555
Cdd:COG5028 228 RSKNDVPEGFDNPSGPNDPRSDRYSRPELKSGVVDFLAPKEY--SLRQPPPPVYVFLIDVSFEAIKNGLVKAAIRAILEN 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 556 LDYLPregNMEESAiRVGFVTYNKVLHFYNVKSSLaQPQMMVVSDVADMFVPLLDG-FLVNVNESRTVITSLLDQIPEMF 634
Cdd:COG5028 306 LDQIP---NFDPRT-KIAIICFDSSLHFFKLSPDL-DEQMLIVSDLDEPFLPFPSGlFVLPLKSCKQIIETLLDRVPRIF 380
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 635 ADTRETETVFGPviqagleALKAA-----ECAGKLFIFHTSLPIAeAPGKLKNRDDKklintdkEKTLFQPQTSFYSNLA 709
Cdd:COG5028 381 QDNKSPKNALGP-------ALKAAksligGTGGKIIVFLSTLPNM-GIGKLQLREDK-------ESSLLSCKDSFYKEFA 445
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 710 KDCVAQGCCVDLFLFPNQYLDVATLGVVTYQTGGSIYKYAYFQLE--ADQDRFLNDLRRDVQKEVGFDAVMRVRTSTGIR 787
Cdd:COG5028 446 IECSKVGISVDLFLTSEDYIDVATLSHLCRYTGGQTYFYPNFSATrpNDATKLANDLVSHLSMEIGYEAVMRVRCSTGLR 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 788 ATDFFGAFYMSNTTDVEMAGLDCDKTITVEFKHDDKLSeDSGALLQCALLYTSCAGQRRLRIHNLSLNCCTQLADLYRNC 867
Cdd:COG5028 526 VSSFYGNFFNRSSDLCAFSTMPRDTSLLVEFSIDEKLM-TSDVYFQVALLYTLNDGERRIRVVNLSLPTSSSIREVYASA 604
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 868 ETDTLINYLAKYAYRGVLNSPVKSVRDSLINQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGpE 947
Cdd:COG5028 605 DQLAIACILAKKASTKALNSSLKEARVLINKSMVDILKAYKKELVKSNTSTQLPLPANLKLLPLLMLALLKSSAFRSG-S 683
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 948 VTTDDRAYIRQLVTSMDVAETNVFFYPRLLPLTKADVDSDS-------LPAAIRNSEERLSKGDIYLLENGLNIFVWVGV 1020
Cdd:COG5028 684 TPSDIRISALNRLTSLPLKQLMRNIYPTLYALHDMPIEAGLpdegllvLPSPINATSSLLESGGLYLIDTGQKIFLWFGK 763
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 1021 NVQQGLIQNLFGVSSFSQISSTLSTLPVLENPFSKKVRSIIDMLHLQ-RSRYMKLIIVKQ--EDKLEMLFKHFLVEDKSL 1097
Cdd:COG5028 764 DAVPSLLQDLFGVDSLSDIPSGKFTLPPTGNEFNERVRNIIGELRSVnDDSTLPLVLVRGggDPSLRLWFFSTLVEDKTL 843
|
810
....*....|....*...
gi 971402013 1098 tGGASYVDFLCHMHKEIR 1115
Cdd:COG5028 844 -NIPSYLDYLQILHEKIK 860
|
|
| Sec24-like |
cd01479 |
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the ... |
524-772 |
1.40e-121 |
|
Sec24-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes of vesicular carriers within the endocytic and the biosynthetic pathways are COP- and clathrin-coated vesicles. Formation of COPII vesicles requires the ordered assembly of the coat built from several cytosolic components GTPase Sar1, complexes of Sec23-Sec24 and Sec13-Sec31. The process is initiated by the conversion of GDP to GTP by the GTPase Sar1 which then recruits the heterodimeric complex of Sec23 and Sec24. This heterodimeric complex generates the pre-budding complex. The final step leading to membrane deformation and budding of COPII-coated vesicles is carried by the heterodimeric complex Sec13-Sec31. The members of this CD belong to the Sec23-like family. Sec 24 is very similar to Sec23. The Sec23 and Sec24 polypeptides fold into five distinct domains: a beta-barrel, a zinc finger, a vWA or trunk, an all helical region and a carboxy Gelsolin domain. The members of this subgroup carry a partial MIDAS motif and have the overall Para-Rossmann type fold that is characteristic of this superfamily.
Pssm-ID: 238756 [Multi-domain] Cd Length: 244 Bit Score: 373.53 E-value: 1.40e-121
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 524 PSPPAFIFMIDVSYNAVKSGLVRLICEELKSILDYLPREgnmeESAIRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 603
Cdd:cd01479 1 PQPAVYVFLIDVSYNAIKSGLLATACEALLSNLDNLPGD----DPRTRVGFITFDSTLHFFNLKSSLEQPQMMVVSDLDD 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 604 MFVPLLDGFLVNVNESRTVITSLLDQIPEMFADTRETETVFGPVIQAGLEALKaaECAGKLFIFHTSLPIAEApGKLKNR 683
Cdd:cd01479 77 PFLPLPDGLLVNLKESRQVIEDLLDQIPEMFQDTKETESALGPALQAAFLLLK--ETGGKIIVFQSSLPTLGA-GKLKSR 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 684 DDKKLINTDKEKTLFQPQTSFYSNLAKDCVAQGCCVDLFLFPNQYLDVATLGVVTYQTGGSIYKYA--YFQLEADQDRFL 761
Cdd:cd01479 154 EDPKLLSTDKEKQLLQPQTDFYKKLALECVKSQISVDLFLFSNQYVDVATLGCLSRLTGGQVYYYPsfNFSAPNDVEKLV 233
|
250
....*....|.
gi 971402013 762 NDLRRDVQKEV 772
Cdd:cd01479 234 NELARYLTRKI 244
|
|
| Sec23_trunk |
pfam04811 |
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
524-768 |
6.62e-115 |
|
Sec23/Sec24 trunk domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface.
Pssm-ID: 398467 [Multi-domain] Cd Length: 241 Bit Score: 355.79 E-value: 6.62e-115
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 524 PSPPAFIFMIDVSYNAVKSGLVRLICEELKSILDYLPREGNMeesaiRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 603
Cdd:pfam04811 1 PQPPVFLFVIDVSYNAIKSGLLAALKESLLQSLDLLPGDPRA-----RVGFITFDSTVHFFNLGSSLRQPQMLVVSDLQD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 604 MFVPLLDGFLVNVNESRTVITSLLDQIPEMFADTRETETVFGPVIQAGLEALKAAECAGKLFIFHTSLPIAEAPGKLKNR 683
Cdd:pfam04811 76 MFLPLPDRFLVPLSECRFVLEDLLEQLPPMFPVTKRPERCLGPALQAAFLLLKAAFTGGKIMVFQGGLPTVGPGGKLKSR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 684 DDKKLINTDKEKTLFQPQT-SFYSNLAKDCVAQGCCVDLFLFPNQYLDVATLGVVTYQTGGSIYKYAYFQLEADQDRFLN 762
Cdd:pfam04811 156 LDESHHGTDKEKAKLVKKAdKFYKSLAKECVKQGHSVDLFAFSLDYVDVATLGQLSRLTGGQVYLYPSFQADVDGSKFKQ 235
|
....*.
gi 971402013 763 DLRRDV 768
Cdd:pfam04811 236 DLQRYF 241
|
|
| trunk_domain |
cd01468 |
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi ... |
524-766 |
8.86e-103 |
|
trunk domain. COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is known as the trunk domain and has an alpha/beta vWA fold and forms the dimer interface. Some members of this family possess a partial MIDAS motif that is a characteristic feature of most vWA domain proteins.
Pssm-ID: 238745 [Multi-domain] Cd Length: 239 Bit Score: 323.43 E-value: 8.86e-103
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 524 PSPPAFIFMIDVSYNAVKSGLVRLICEELKSILDYLPREGNMeesaiRVGFVTYNKVLHFYNVKSSLAQPQMMVVSDVAD 603
Cdd:cd01468 1 PQPPVFVFVIDVSYEAIKEGLLQALKESLLASLDLLPGDPRA-----RVGLITYDSTVHFYNLSSDLAQPKMYVVSDLKD 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 604 MFVPLLDGFLVNVNESRTVITSLLDQIPEMFAD--TRETETVFGPVIQAGLEALKAAECAGKLFIFHTSLPIAEaPGKLK 681
Cdd:cd01468 76 VFLPLPDRFLVPLSECKKVIHDLLEQLPPMFWPvpTHRPERCLGPALQAAFLLLKGTFAGGRIIVFQGGLPTVG-PGKLK 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 682 NRDDKKLINTDKEKTLFQPQTSFYSNLAKDCVAQGCCVDLFLFPNQYLDVATLGVVTYQTGGSIYKYAYFQLEADQDRFL 761
Cdd:cd01468 155 SREDKEPIRSHDEAQLLKPATKFYKSLAKECVKSGICVDLFAFSLDYVDVATLKQLAKSTGGQVYLYDSFQAPNDGSKFK 234
|
....*
gi 971402013 762 NDLRR 766
Cdd:cd01468 235 QDLQR 239
|
|
| PTZ00395 |
PTZ00395 |
Sec24-related protein; Provisional |
522-1116 |
1.73e-49 |
|
Sec24-related protein; Provisional
Pssm-ID: 185594 [Multi-domain] Cd Length: 1560 Bit Score: 192.60 E-value: 1.73e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 522 KFPS-----PPAFIFMIDVSYNAVKSGLVRLICEELKSILDylpregNMEESAIRVGFVTYNKVLHFYNVKSSLAQP--- 593
Cdd:PTZ00395 943 KYPQvknmlPPYFVFVVECSYNAIYNNITYTILEGIRYAVQ------NVKCPQTKIAIITFNSSIYFYHCKGGKGVSgee 1016
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 594 ----------QMMVVSDVADMFVPL-LDGFLVNVNESRTVITSLLDQIPEMFADTRETETVFGPVIQAGLEALKAAECAG 662
Cdd:PTZ00395 1017 gdggggsgnhQVIVMSDVDDPFLPLpLEDLFFGCVEEIDKINTLIDTIKSVSTTMQSYGSCGNSALKIAMDMLKERNGLG 1096
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 663 KLFIFHTSLPIAeAPGKLKnrddkKLINTDKEKTLFQPQTSFYSNLAKDCVAQGCCVDLFLFP--NQYLDVATLGVVTYQ 740
Cdd:PTZ00395 1097 SICMFYTTTPNC-GIGAIK-----ELKKDLQENFLEVKQKIFYDSLLLDLYAFNISVDIFIISsnNVRVCVPSLQYVAQN 1170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 741 TGGSIYKYAYFQLEAD-QDRFLNDLRRDVQKEVGFDAVMRVRTSTGIRATDFFGAFYMSNTT----DVEMAGLDCDKTIT 815
Cdd:PTZ00395 1171 TGGKILFVENFLWQKDyKEIYMNIMDTLTSEDIAYCCELKLRYSHHMSVKKLFCCNNNFNSIisvdTIKIPKIRHDQTFA 1250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 816 VEFKHDDKLSEDSGALLQCALLYTSCAGQRRLRIHNLSLNCCTQLADLYRNCETDTLINYLAKYAYRGVLNSPVKSvrDS 895
Cdd:PTZ00395 1251 FLLNYSDISESKKQIYFQCACIYTNLWGDRFVRLHTTHMNLTSSLSTVFRYTDAEALMNILIKQLCTNILHNDNYS--KI 1328
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 896 LINQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQpgPEVTTDDRAYIRQLVTSMDVAETNVFFYP- 974
Cdd:PTZ00395 1329 IIDNLAAILFSYRINCASSAHSGQLILPDTLKLLPLFTSSLLKHNVTK--KEILHDLKVYSLIKLLSMPIISSLLYVYPv 1406
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 975 --------RLLPLTKADVDSD-SLPAAIRNSEERLSKGDIYLLENGLNIFVWVGVNVQQGLIQNLFGVSSFSQISSTLSt 1045
Cdd:PTZ00395 1407 myvihikgKTNEIDSMDVDDDlFIPKTIPSSAEKIYSNGIYLLDACTHFYLYFGFHSDANFAKEIVGDIPTEKNAHELN- 1485
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971402013 1046 lpVLENPFSKKVRSIIDML----HLqrSRYMKLIIVKQEDKLEMLFKHFLVEDKSlTGGASYVDFLCHMHKEIRQ 1116
Cdd:PTZ00395 1486 --LTDTPNAQKVQRIIKNLsrihHF--NKYVPLVMVAPKSNEEEHLISLCVEDKA-DKEYSYVNFLCFIHKLVHK 1555
|
|
| Sec23_helical |
pfam04815 |
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic ... |
870-968 |
3.23e-35 |
|
Sec23/Sec24 helical domain; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is composed of five alpha helices.
Pssm-ID: 461441 [Multi-domain] Cd Length: 103 Bit Score: 129.54 E-value: 3.23e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 870 DTLINYLAKYAYRGVLNSPVKSVRDSLINQCAQILACYRKNCASPSSAGQLILPECMKLLPVYLNCVLKSDVLQPGPEVT 949
Cdd:pfam04815 3 EAIAVLLAKKAVEKALSSSLSDAREALDNKLVDILAAYRKYCASSSSPGQLILPESLKLLPLYMLALLKSPALRGGNSSP 82
|
90
....*....|....*....
gi 971402013 950 TDDRAYIRQLVTSMDVAET 968
Cdd:pfam04815 83 SDERAYARHLLLSLPVEEL 101
|
|
| Sec23_BS |
pfam08033 |
Sec23/Sec24 beta-sandwich domain; |
773-856 |
6.02e-30 |
|
Sec23/Sec24 beta-sandwich domain;
Pssm-ID: 429794 [Multi-domain] Cd Length: 86 Bit Score: 113.79 E-value: 6.02e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 773 GFDAVMRVRTSTGIRATDFFGAFYMSNTTD-VEMAGLDCDKTITVEFKHDDKLSEDSGALLQCALLYTSCAGQRRLRIHN 851
Cdd:pfam08033 1 GFNAVLRVRTSKGLKVSGFIGNFVSRSSGDtWKLPSLDPDTSYAFEFDIDEPLPNGSNAYIQFALLYTHSSGERRIRVTT 80
|
....*
gi 971402013 852 LSLNC 856
Cdd:pfam08033 81 VALPV 85
|
|
| PLN00162 |
PLN00162 |
transport protein sec23; Provisional |
403-849 |
2.00e-20 |
|
transport protein sec23; Provisional
Pssm-ID: 215083 [Multi-domain] Cd Length: 761 Bit Score: 97.32 E-value: 2.00e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 403 SYNI-PCTSDMAKQSQVPLAAVIKPLATLPPEETLPYlvdhgesGPVRCNRCKAYMCPFMQFIEGGRRFQCCFCSCVTEV 481
Cdd:PLN00162 15 SWNVwPSSKIEASKCVIPLAALYTPLKPLPELPVLPY-------DPLRCRTCRAVLNPYCRVDFQAKIWICPFCFQRNHF 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 482 PAHYF----QHLDhtgkrvdfydrPELslgsYEFLATVDY---CKNNKFPSPPAFIFMIDVS-----YNAVKSglvrlic 549
Cdd:PLN00162 88 PPHYSsiseTNLP-----------AEL----FPQYTTVEYtlpPGSGGAPSPPVFVFVVDTCmieeeLGALKS------- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 550 eELKSILDYLPregnmeESAiRVGFVTY----------------------------NKVLHFYNVKSSLAQPQMMVVSDV 601
Cdd:PLN00162 146 -ALLQAIALLP------ENA-LVGLITFgthvhvhelgfsecsksyvfrgnkevskDQILEQLGLGGKKRRPAGGGIAGA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 602 ADMFVPL-LDGFLVNVNESRTVITSLLDQI-PEMF---ADTRETETVfGPVIQ--AGLEALKAAECAGKLFIFhTSLPIA 674
Cdd:PLN00162 218 RDGLSSSgVNRFLLPASECEFTLNSALEELqKDPWpvpPGHRPARCT-GAALSvaAGLLGACVPGTGARIMAF-VGGPCT 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 675 EAPGKLKNRDDKKLINTDKE-----KTLFQPQTSFYSNLAKDCVAQGCCVDLFLFPnqyLD---VATLGVVTYQTGGSIY 746
Cdd:PLN00162 296 EGPGAIVSKDLSEPIRSHKDldkdaAPYYKKAVKFYEGLAKQLVAQGHVLDVFACS---LDqvgVAEMKVAVERTGGLVV 372
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 747 KYAYFqleaDQDRFLNDLRRDVQKE------VGFDAVMRVRTSTGIRATDFFG---------------AFYMSNTTDVEM 805
Cdd:PLN00162 373 LAESF----GHSVFKDSLRRVFERDgegslgLSFNGTFEVNCSKDVKVQGAIGpcaslekkgpsvsdtEIGEGGTTAWKL 448
|
490 500 510 520
....*....|....*....|....*....|....*....|....*....
gi 971402013 806 AGLDCDKTITVEFKHDDKLSEDSGA-----LLQCALLYTSCAGQRRLRI 849
Cdd:PLN00162 449 CGLDKKTSLAVFFEVANSGQSNPQPpgqqfFLQFLTRYQHSNGQTRLRV 497
|
|
| zf-Sec23_Sec24 |
pfam04810 |
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum ... |
447-484 |
6.11e-16 |
|
Sec23/Sec24 zinc finger; COPII-coated vesicles carry proteins from the endoplasmic reticulum to the Golgi complex. This vesicular transport can be reconstituted by using three cytosolic components containing five proteins: the small GTPase Sar1p, the Sec23p/24p complex, and the Sec13p/Sec31p complex. This domain is found to be zinc binding domain.
Pssm-ID: 461437 [Multi-domain] Cd Length: 38 Bit Score: 72.48 E-value: 6.11e-16
10 20 30
....*....|....*....|....*....|....*...
gi 971402013 447 PVRCNRCKAYMCPFMQFIEGGRRFQCCFCSCVTEVPAH 484
Cdd:pfam04810 1 PVRCRRCRAYLNPFCQFDFGGKKWTCNFCGTRNPVPPE 38
|
|
| SEC23 |
COG5047 |
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion]; |
399-1024 |
2.90e-14 |
|
Vesicle coat complex COPII, subunit SEC23 [Intracellular trafficking and secretion];
Pssm-ID: 227380 [Multi-domain] Cd Length: 755 Bit Score: 77.61 E-value: 2.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 399 IRCTSYNIPCTSDMAKQSQVPLAAVIKPLATLPPEETLPYlvdhgesGPVRCNR-CKAYMCPFMQFIEGGRRFQCCFCSC 477
Cdd:COG5047 12 IRLTWNVFPATRGDATRTVIPIACLYTPLHEDDALTVNYY-------EPVKCTApCKAVLNPYCHIDERNQSWICPFCNQ 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 478 VTEVPAHYfqhLDHTGKRVDfydrPELSLGSyeflATVDYCKNNKFPSPPAFIFMIDVsynAVKSGLVRLICEELKSILD 557
Cdd:COG5047 85 RNTLPPQY---RDISNANLP----LELLPQS----STIEYTLSKPVILPPVFFFVVDA---CCDEEELTALKDSLIVSLS 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 558 YLPREgnmeesAIrVGFVTYNKVLHFYNVkSSLAQPQMMVVSDVADMFVPLLD--------------------------- 610
Cdd:COG5047 151 LLPPE------AL-VGLITYGTSIQVHEL-NAENHRRSYVFSGNKEYTKENLQellalskptksggfeskisgigqfass 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 611 GFLVNVNESRTVITSLLDQIPEmfaDTRETETVFGPVIQAGLeALKAA---------ECAGKLFIFhTSLPIAEAPGKLK 681
Cdd:COG5047 223 RFLLPTQQCEFKLLNILEQLQP---DPWPVPAGKRPLRCTGS-ALNIAsslleqcfpNAGCHIVLF-AGGPCTVGPGTVV 297
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 682 NRDDKK------LINTDKEKtLFQPQTSFYSNLAKDCVAQGCCVDLFLFPNQYLDVATLGVVTYQTGGSIYKYAYFQLEA 755
Cdd:COG5047 298 STELKEpmrshhDIESDSAQ-HSKKATKFYKGLAERVANQGHALDIFAGCLDQIGIMEMEPLTTSTGGALVLSDSFTTSI 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 756 DQDRFLNDLRRDVQK--EVGFDAVMRVRTSTGIRATDFFG---------------AFYMSNTTDVEMAGLDCDKTITVEF 818
Cdd:COG5047 377 FKQSFQRIFNRDSEGylKMGFNANMEVKTSKNLKIKGLIGhavsvkkkannisdsEIGIGATNSWKMASLSPKSNYALYF 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 819 K-----HDDKLSEDSGALLQCALLYTSCAGQRRLRIHNLSLNCCTQLADL-YRNCETDTLINYLAKYAyrgVLNSPVKSV 892
Cdd:COG5047 457 EialgaASGSAQRPAEAYIQFITTYQHSSGTYRIRVTTVARMFTDGGLPKiNRSFDQEAAAVFMARIA---AFKAETEDI 533
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 893 RDS-------LINQCaQILACYRKNcaSPSSAGqliLPECMKLLPVYLNCVLKSDVLQPGpEVTTDDRAYIRQLVTSMDV 965
Cdd:COG5047 534 IDVfrwidrnLIRLC-QKFADYRKD--DPSSFR---LDPNFTLYPQFMYHLRRSPFLSVF-NNSPDETAFYRHMLNNADV 606
|
650 660 670 680 690 700
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971402013 966 AETNVFFYPRLLPLTKAD------VDSDSLPAAIrnseerlskgdIYLLENGLNIFVWVGVNVQQ 1024
Cdd:COG5047 607 NDSLIMIQPTLQSYSFEKggvpvlLDSVSVKPDV-----------ILLLDTFFHILIFHGSYIAQ 660
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
3-281 |
3.26e-13 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 74.42 E-value: 3.26e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 3 VNQHTHAGPPygqPQPGYQGYQQPAYGGqPLPGVPHT-QYGAYNGPMPGYQQPVPP-----QGSVRALPTSGAPPPASGT 76
Cdd:pfam03154 249 LQPMTQPPPP---SQVSPQPLPQPSLHG-QMPPMPHSlQTGPSHMQHPVPPQPFPLtpqssQSQVPPGPSPAAPGQSQQR 324
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 77 SLPSGHQGYSQFGQGDVQNGIPTSTAPMQ--RPPASQPFLPGSA------PAPVSQPSTFQQYG--PPPCSVQQLSNHMa 146
Cdd:pfam03154 325 IHTPPSQSQLQSQQPPREQPLPPAPLSMPhiKPPPTTPIPQLPNpqshkhPPHLSGPSPFQMNSnlPPPPALKPLSSLS- 403
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 147 gmTIGSTSVSAPP----PAGLGYGPPTSVPPV---SGSFSATGSGLYTPYTASPGPpppsvpqglplAQPPFSGQPVPTQ 219
Cdd:pfam03154 404 --THHPPSAHPPPlqlmPQSQQLPPPPAQPPVltqSQSLPPPAASHPPTSGLHQVP-----------SQSPFPQHPFVPG 470
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971402013 220 RLPTEVPGFAPPPPA----TGIGASSYPPPTGAPRPPPMPGPPLSGQTVAGPPMSQPNHVSSPPPP 281
Cdd:pfam03154 471 GPPPITPPSGPPTSTssamPGIQPPSSASVSSSGPVPAAVSCPLPPVQIKEEALDEAEEPESPPPP 536
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
46-380 |
3.15e-10 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 64.96 E-value: 3.15e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 46 GPMPGYQQPVPPQGSvralPTSGAPPPASGTSLPSGHQGYSQFGQgdvqngiPTSTAPMQRPPASQPFLPGSAPAPVSQP 125
Cdd:PHA03247 2693 GSLTSLADPPPPPPT----PEPAPHALVSATPLPPGPAAARQASP-------ALPAAPAPPAVPAGPATPGGPARPARPP 2761
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 126 STfqqYGPPpcsvqqlsnhmagmtigstsvSAPPPAGLGYGPP--TSVPPVSGSFSATGSGLYTPYTASPGPPPPSVPQG 203
Cdd:PHA03247 2762 TT---AGPP---------------------APAPPAAPAAGPPrrLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAA 2817
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 204 LPLAQPPFSGQPVPTQRLPTEVPGFAPPPPATGIGASSYPPPTGAPRPPPMPGPPLSGQTVAGPPMSQPNHVSSPPPPLT 283
Cdd:PHA03247 2818 LPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTES 2897
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 284 LSGPHPGPPMSGPPPPTHPPQPGYQMQQNgsfgqvrgPQPNyggayPGTPNYGSQPGPPPKRLDPDSIPSPIQVIEDDRN 363
Cdd:PHA03247 2898 FALPPDQPERPPQPQAPPPPQPQPQPPPP--------PQPQ-----PPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWL 2964
|
330
....*....|....*..
gi 971402013 364 NRGSEPFVTGVRGQVPP 380
Cdd:PHA03247 2965 GALVPGRVAVPRFRVPQ 2981
|
|
| Gelsolin |
pfam00626 |
Gelsolin repeat; |
989-1061 |
3.60e-10 |
|
Gelsolin repeat;
Pssm-ID: 395501 [Multi-domain] Cd Length: 76 Bit Score: 57.32 E-value: 3.60e-10
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971402013 989 LPAAIRNSEERLSKGDIYLLENGLNIFVWVGVNvqQGLIQNLFGVSSFSQISST-LSTLPVLEN-PFSKKVRSII 1061
Cdd:pfam00626 4 LPPPVPLSQESLNSGDCYLLDNGFTIFLWVGKG--SSLLEKLFAALLAAQLDDDeRFPLPEVIRvPQGKEPARFL 76
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
8-350 |
2.79e-08 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 58.41 E-value: 2.79e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 8 HAGPPYGQPQPgyqgyqQPAYGGQPLPGVPHTQYGAYNGPMPGYQQPVPPQGSvrALPTSGAPPPASGTSlpsghqgysq 87
Cdd:PHA03247 2702 PPPPPTPEPAP------HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGP--ATPGGPARPARPPTT---------- 2763
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 88 fgqgdvqNGIPTSTAPMQRPPASQPFL--PGSAPAPVSQPSTFQQYGPPPCSVQQLSNHMAGMTIGS-TSVSAPPPAGLG 164
Cdd:PHA03247 2764 -------AGPPAPAPPAAPAAGPPRRLtrPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASpAGPLPPPTSAQP 2836
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 165 YGPPTSVPPVSGSFS-----ATGSGLYTPYTASPGPPPPSVPQGLP---LAQPPFSGQPVPtQRLPTEVPGFAPPPPAtg 236
Cdd:PHA03247 2837 TAPPPPPGPPPPSLPlggsvAPGGDVRRRPPSRSPAAKPAAPARPPvrrLARPAVSRSTES-FALPPDQPERPPQPQA-- 2913
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 237 igassyppptgapRPPPMPGPPLSGQTVAGPPMSQPNHVSSPPPPLTlsgphpgppmsgPPPPTHPPQPGYQMQQNGSFG 316
Cdd:PHA03247 2914 -------------PPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTT------------DPAGAGEPSGAVPQPWLGALV 2968
|
330 340 350
....*....|....*....|....*....|....
gi 971402013 317 QVRGPQPNYGGAYPGTPNYGSQPGPPPKRLDPDS 350
Cdd:PHA03247 2969 PGRVAVPRFRVPQPAPSREAPASSTPPLTGHSLS 3002
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
15-353 |
4.71e-08 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 57.47 E-value: 4.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 15 QPQPGYQGYQQPAYGgQPLPGVPHTQYGAYNGPMPGyQQPVPPQGSVralPTSgaPPPASGTSLPSGHQGYSQFGQGDVQ 94
Cdd:pfam03154 168 QTQPPVLQAQSGAAS-PPSPPPPGTTQAATAGPTPS-APSVPPQGSP---ATS--QPPNQTQSTAAPHTLIQQTPTLHPQ 240
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 95 NgIPTSTAPMQrpPASQPFLPGS-APAPVSQPSTFQQYGPPPCSVQQLSNHMAgMTIGSTSVSAPPPAGLGYGPPTSVPP 173
Cdd:pfam03154 241 R-LPSPHPPLQ--PMTQPPPPSQvSPQPLPQPSLHGQMPPMPHSLQTGPSHMQ-HPVPPQPFPLTPQSSQSQVPPGPSPA 316
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 174 VSGSFSATgsgLYTPytaspgppppsVPQGLPLAQPPFSGQPVPTQrlPTEVPGFAPPP----PATGIGASSYPPPTGAP 249
Cdd:pfam03154 317 APGQSQQR---IHTP-----------PSQSQLQSQQPPREQPLPPA--PLSMPHIKPPPttpiPQLPNPQSHKHPPHLSG 380
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 250 RPPPMPGPPLSGQTVAGPPMSQPNH--VSSPPPPLTLSGPHPGPPMSGPPPPThppqpgyqMQQNGSFGQVRGPQPNYGG 327
Cdd:pfam03154 381 PSPFQMNSNLPPPPALKPLSSLSTHhpPSAHPPPLQLMPQSQQLPPPPAQPPV--------LTQSQSLPPPAASHPPTSG 452
|
330 340 350
....*....|....*....|....*....|.
gi 971402013 328 AYPGT-----PNYGSQPGPPPKRLDPDSIPS 353
Cdd:pfam03154 453 LHQVPsqspfPQHPFVPGGPPPITPPSGPPT 483
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
9-234 |
9.61e-07 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 53.07 E-value: 9.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 9 AGPPYGQPQPGYQGYQQPAYGGQPLPGVPHTQYGAYNGPMPGYQQPVPPQGSVRALPTSGAPPPASGTSLPSGhqgysqf 88
Cdd:PRK07764 598 EGPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP------- 670
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 89 gqGDVQNGIPTSTAPMQRPPASqpflPGSAPAPVSQPSTFQQYGPPPCSVQQLSNHMAGmtiGSTSVSAPPPAGLGYGPP 168
Cdd:PRK07764 671 --AKAGGAAPAAPPPAPAPAAP----AAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQ---AAQGASAPSPAADDPVPL 741
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 971402013 169 TSVPPVSGSFSATGSGLYTPytaspgppppsvpQGLPLAQPPFSGQPVPTQRLPTEVPGFAPPPPA 234
Cdd:PRK07764 742 PPEPDDPPDPAGAPAQPPPP-------------PAPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMD 794
|
|
| Pro-rich |
pfam15240 |
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
5-135 |
5.00e-06 |
|
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 48.11 E-value: 5.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 5 QHTHAGPPYGQPQPGyqGYQQ-PAYGGQPLPGVPHTQYGayNGPMPGYQQPVPPQGSvralPTSGAPPPasgtslPSGHQ 83
Cdd:pfam15240 57 QPPASDDPPGPPPPG--GPQQpPPQGGKQKPQGPPPQGG--PRPPPGKPQGPPPQGG----NQQQGPPP------PGKPQ 122
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 971402013 84 GYSQFGQGDvqngiPTSTAPMQRPPASQPFLPGSAPAPVSQPStfQQYGPPP 135
Cdd:pfam15240 123 GPPPQGGGP-----PPQGGNQQGPPPPPPGNPQGPPQRPPQPG--NPQGPPQ 167
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
5-137 |
1.50e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 49.55 E-value: 1.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 5 QHTHAGPPYGQPQPGYQGYQQPAYGGQPLPGVPHTQYGAY------------NGPMPGYQQPVPPQGSVRALPTSG---- 68
Cdd:PHA03247 2928 QPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALvpgrvavprfrvPQPAPSREAPASSTPPLTGHSLSRvssw 3007
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 69 ----------APPPAS---------------GTSLPSGHQGYSQFGQGDVQNGIPTStapmqrPPASQPFLPgsAPAPVS 123
Cdd:PHA03247 3008 asslalheetDPPPVSlkqtlwppddtedsdADSLFDSDSERSDLEALDPLPPEPHD------PFAHEPDPA--TPEAGA 3079
|
170
....*....|....
gi 971402013 124 QPSTFQQYGPPPCS 137
Cdd:PHA03247 3080 RESPSSQFGPPPLS 3093
|
|
| PAT1 |
pfam09770 |
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ... |
8-143 |
1.57e-05 |
|
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.
Pssm-ID: 401645 [Multi-domain] Cd Length: 846 Bit Score: 49.26 E-value: 1.57e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 8 HAGPPYGQPQPGYQGYQQPAyggqplpgvPHTQYGAYNGPMPGYQQPVPPQG-SVRAL--PTSGAPPPASGTSLPSGHQG 84
Cdd:pfam09770 218 PAQPPAAPPAQQAQQQQQFP---------PQIQQQQQPQQQPQQPQQHPGQGhPVTILqrPQSPQPDPAQPSIQPQAQQF 288
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 971402013 85 YSQFGQGDVQngiPT------STAPMQRPPASQPFLPGSAPAP--VSQPSTFQQYGPPPCSV--QQLSN 143
Cdd:pfam09770 289 HQQPPPVPVQ---PTqilqnpNRLSAARVGYPQNPQPGVQPAPahQAHRQQGSFGRQAPIIThpQQLAQ 354
|
|
| PHA03377 |
PHA03377 |
EBNA-3C; Provisional |
9-173 |
1.84e-05 |
|
EBNA-3C; Provisional
Pssm-ID: 177614 [Multi-domain] Cd Length: 1000 Bit Score: 48.90 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 9 AGPPygQPQPGYQGYQQPayggqplpgvPHTQygaynGPMPGYQQPVPPQG--------SVRALPTSGAPPPASGTSLPS 80
Cdd:PHA03377 739 APPP--SHQAPYSGHEEP----------QAQQ-----APYPGYWEPRPPQApylgyqepQAQGVQVSSYPGYAGPWGLRA 801
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 81 GHQGYSQ---FGQGDVQNGiPTSTAPMQRPPASQPFLPGSAPAPVSQPSTFQ----QYGPPP---CSVQQLSNHMAGMTI 150
Cdd:PHA03377 802 QHPRYRHswaYWSQYPGHG-HPQGPWAPRPPHLPPQWDGSAGHGQDQVSQFPhlqsETGPPRlqlSQVPQLPYSQTLVSS 880
|
170 180
....*....|....*....|...
gi 971402013 151 GSTSVSAPPPAGLGYGPPTSVPP 173
Cdd:PHA03377 881 SAPSWSSPQPRAPIRPIPTRFPP 903
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
15-160 |
3.42e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 48.16 E-value: 3.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 15 QPQPGYQGyQQPAYGGQPLPGVPHTQYG----AYNGPmpgYQQPVPPQGSVRALPTSGAPPPASGTSLPSGHQGYSQFGQ 90
Cdd:PRK10263 361 QPVPGPQT-GEPVIAPAPEGYPQQSQYAqpavQYNEP---LQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAP 436
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 91 GDVQngiPTSTAPMQRPPASQPFlpgsAPAPVSQPstFQQYGPPpcsVQQLSNHMAGMTIGSTSVSAPPP 160
Cdd:PRK10263 437 APEQ---PVAGNAWQAEEQQSTF----APQSTYQT--EQTYQQP---AAQEPLYQQPQPVEQQPVVEPEP 494
|
|
| Pro-rich |
pfam15240 |
Proline-rich protein; This family includes several eukaryotic proline-rich proteins. |
12-140 |
7.21e-05 |
|
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
Pssm-ID: 464580 [Multi-domain] Cd Length: 167 Bit Score: 44.64 E-value: 7.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 12 PYGQPQPGYQGYQQPAYGGQPLPgvphtqygaynGPMPGYQQPVPPQGSVRALPTSGAPPPASGTSLPSGHQGYSQFGQG 91
Cdd:pfam15240 35 EEGQSQQGGQGPQGPPPGGFPPQ-----------PPASDDPPGPPPPGGPQQPPPQGGKQKPQGPPPQGGPRPPPGKPQG 103
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 971402013 92 DVQNGIPTSTAPMQRPPASQPFLPGSAPAPvsQPSTFQQYGPPPCSVQQ 140
Cdd:pfam15240 104 PPPQGGNQQQGPPPPGKPQGPPPQGGGPPP--QGGNQQGPPPPPPGNPQ 150
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
7-234 |
7.34e-05 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 46.90 E-value: 7.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 7 THAGPPYGQPQPGYQGYQQPAYGGQPlpgvphTQYGAYNGPMPGYQQPVPPQGSVRALPTSGAPPPASGTSLPSGHQGYS 86
Cdd:PRK07764 590 PAPGAAGGEGPPAPASSGPPEEAARP------AAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDAS 663
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 87 QfgQGDVQNGIPTSTAPMQRPPASQPFLP-GSAPAPVSQPSTFQQYGPPPCSVQQLSNHMAGmtiGSTSVSAPPPAGLGY 165
Cdd:PRK07764 664 D--GGDGWPAKAGGAAPAAPPPAPAPAAPaAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQ---AAQGASAPSPAADDP 738
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 971402013 166 GPPTSVPPvsgsfsatgsglytpytaspgppppsvPQGLPLAQPPFSGQPVPTQRLPTEVPGFAPPPPA 234
Cdd:PRK07764 739 VPLPPEPD---------------------------DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPS 780
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
34-279 |
7.82e-05 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 47.07 E-value: 7.82e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 34 PGVPHTQYGAYNGPMPGYQQPVPPQGSVRALPTSGAPPPASGTSLPSghqgysqfgqgdvqngiptsTAPMQRPPASQPF 113
Cdd:pfam03154 146 PSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTT--------------------QAATAGPTPSAPS 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 114 LPGSAPAPVSQPSTFQQYGPPPCSVQQlsnhmAGMTIGSTSVSAPPPAGLGYGPPTsvPPVSGSFSATGS-GLYTPytas 192
Cdd:pfam03154 206 VPPQGSPATSQPPNQTQSTAAPHTLIQ-----QTPTLHPQRLPSPHPPLQPMTQPP--PPSQVSPQPLPQpSLHGQ---- 274
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 193 pgppppSVPQGLPL-AQPPFSGQPVPTQRLPTEVP---GFAPPPPATGI-GASSYPPPTGAPRPPPMPGPPLSGQTVAGP 267
Cdd:pfam03154 275 ------MPPMPHSLqTGPSHMQHPVPPQPFPLTPQssqSQVPPGPSPAApGQSQQRIHTPPSQSQLQSQQPPREQPLPPA 348
|
250
....*....|..
gi 971402013 268 PMSQPnHVSSPP 279
Cdd:pfam03154 349 PLSMP-HIKPPP 359
|
|
| SSDP |
pfam04503 |
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA ... |
46-176 |
1.19e-04 |
|
Single-stranded DNA binding protein, SSDP; This is a family of eukaryotic single-stranded DNA binding proteins with specificity to a pyrimidine-rich element found in the promoter region of the alpha2(I) collagen gene.
Pssm-ID: 461334 [Multi-domain] Cd Length: 293 Bit Score: 45.33 E-value: 1.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 46 GPMPGYQQPVPPqGSVRALPTSGAPPPASGTSLPSGHQGYSQFGQGDVQNGIPTSTAPMQR-----PPASQPFLPGSApA 120
Cdd:pfam04503 37 GPMPPGFFQSPP-SHPSSQPSPHAQPPPHNPATMMGPHSQPFMGPRYPGGPRPSVRMPQQGndfngPPGQQPMMPNSM-D 114
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971402013 121 PVSQPSTFQQYGPPPCSVQQLSNHMAGMTIGSTSVS--APPP---AGLGYGPPTSVPPVSG 176
Cdd:pfam04503 115 PTRPGGHPNMGGPMQRMNPPRGPGMGPMGPQSYGPGmrGPPPnstDGPGGMPPMNMGPGGR 175
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
5-173 |
1.32e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 46.21 E-value: 1.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 5 QHTHAGPPYGQPQPGYQGYQQPAyGGQPLPGVPHTQYGAYNGPMPGYQQPVPPQGSVRALPTSGAPPPASGTSL------ 78
Cdd:PHA03378 735 RPPAAAPGRARPPAAAPGRARPP-AAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMqlmpra 813
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 79 PSGHQGYS-----QFGQGDVQNGIPTSTAPM----QRPPASQPFLPGSAPAPVSQPSTFQqygPPPCSVQQLSNHMAGMT 149
Cdd:PHA03378 814 APGQQGPTkqilrQLLTGGVKRGRPSLKKPAalerQAAAGPTPSPGSGTSDKIVQAPVFY---PPVLQPIQVMRQLGSVR 890
|
170 180 190
....*....|....*....|....*....|.
gi 971402013 150 IGSTSVSAPPPA-------GLGYGPPTSVPP 173
Cdd:PHA03378 891 AAAASTVTQAPTeytgerrGVGPMHPTDIPP 921
|
|
| PABP-1234 |
TIGR01628 |
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ... |
2-148 |
1.44e-04 |
|
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.
Pssm-ID: 130689 [Multi-domain] Cd Length: 562 Bit Score: 45.95 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 2 SVNQHTHAGPPYGQPQPGYQgyqqpaYGGQPLpGVPHTQygayngPMPGYQQPVPPQGsvralPTSGAPPPASGTSlpsg 81
Cdd:TIGR01628 389 SPMGGAMGQPPYYGQGPQQQ------FNGQPL-GWPRMS------MMPTPMGPGGPLR-----PNGLAPMNAVRAP---- 446
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 971402013 82 hqgysqfGQGDVQNGIPTSTAPMQRPPASQPfLPGSAPAPVSQPSTFQQyGPPPCSVQQLSNHMAGM 148
Cdd:TIGR01628 447 -------SRNAQNAAQKPPMQPVMYPPNYQS-LPLSQDLPQPQSTASQG-GQNKKLAQVLASATPQM 504
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
40-236 |
2.00e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 45.64 E-value: 2.00e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 40 QYGAYNGPMPGYQQPVPPQGSVRALPTSGAPPPASGTSLPSGHQGYSQFGQGDVQNGIPTSTAPMQRPPASQPFLPG--- 116
Cdd:PRK12323 367 QSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGpgg 446
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 117 -SAPAPVSQPSTFQQYGPPPCSVQQLSNHMAGMTIGSTSVSAPPPAGLGYGPPTSVPPVSGSFSATGSGLYTPYTASPGP 195
Cdd:PRK12323 447 aPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVAESI 526
|
170 180 190 200
....*....|....*....|....*....|....*....|....
gi 971402013 196 PPPSVPQ---GLPLAQPPFSGQPVPTQRLPTEvPGFAPPPPATG 236
Cdd:PRK12323 527 PDPATADpddAFETLAPAPAAAPAPRAAAATE-PVVAPRPPRAS 569
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
24-135 |
4.74e-04 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 43.31 E-value: 4.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 24 QQPAyGGQPLPGVPHTqygayngPMPGYQQPVPPQGSVRALPTSGAP----PPASGTSLPSGHQGYSQfgqGDVQNGIPT 99
Cdd:PHA02682 74 QRPS-GQSPLAPSPAC-------AAPAPACPACAPAAPAPAVTCPAPapacPPATAPTCPPPAVCPAP---ARPAPACPP 142
|
90 100 110
....*....|....*....|....*....|....*.
gi 971402013 100 STApmQRPPAsqPFLPGSAPAPVSQPSTFQQYGPPP 135
Cdd:PHA02682 143 STR--QCPPA--PPLPTPKPAPAAKPIFLHNQLPPP 174
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
47-283 |
5.59e-04 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 44.29 E-value: 5.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 47 PMPGYQQ-PVPPQGSVRALPTSGAPPPASGTSLPSGHqGYSQFGQGDVQNGIPTSTAPMQRPPASQP------------F 113
Cdd:PHA03378 565 PAPGLGPlQIQPLTSPTTSQLASSAPSYAQTPWPVPH-PSQTPEPPTTQSHIPETSAPRQWPMPLRPipmrplrmqpitF 643
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 114 LPGSAPAPVSQP--------STFQQYGPPPCSVQQlSNHMAGMTIGSTSVSA-PPPAGLGYGPPTSVPPVSGSFSATGSG 184
Cdd:PHA03378 644 NVLVFPTPHQPPqveitpykPTWTQIGHIPYQPSP-TGANTMLPIQWAPGTMqPPPRAPTPMRPPAAPPGRAQRPAAATG 722
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 185 LYTPYTASPGPPPPSvpQGLPLAQPPFSGQPVPTQRlPTEVPGFAPPPPATGiGASSypPPTGAPRPPPMPGPPLSGQTV 264
Cdd:PHA03378 723 RARPPAAAPGRARPP--AAAPGRARPPAAAPGRARP-PAAAPGRARPPAAAP-GAPT--PQPPPQAPPAPQQRPRGAPTP 796
|
250
....*....|....*....
gi 971402013 265 AGPPMSQPNHVSSPPPPLT 283
Cdd:PHA03378 797 QPPPQAGPTSMQLMPRAAP 815
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
46-285 |
5.63e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 5.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 46 GPMPGYQQPVPPQGSVRALPTSGAPPPASGTSLPSGH-------QGYSQFGQGDVQNGIPTSTAPMQRPPAS---QPFLP 115
Cdd:PHA03247 2550 DPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRArrpdappQSARPRAPVDDRGDPRGPAPPSPLPPDThapDPPPP 2629
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 116 GSAPAPVSQPSTFQQYGPPPC------SVQQLSNHMAGMTIGSTSVSAPPPAGlgYGPPTSVPPVsGSFSATGSGLYTPY 189
Cdd:PHA03247 2630 SPSPAANEPDPHPPPTVPPPErprddpAPGRVSRPRRARRLGRAAQASSPPQR--PRRRAARPTV-GSLTSLADPPPPPP 2706
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 190 TASPGPPPPSVPQGLPLAqPPFSGQPVPTqrlPTEVPgfAPPPPATGIGASSyppptgaprpppMPGPPLSGQTVAGPPM 269
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPG-PAAARQASPA---LPAAP--APPAVPAGPATPG------------GPARPARPPTTAGPPA 2768
|
250
....*....|....*.
gi 971402013 270 SQPNHVSSPPPPLTLS 285
Cdd:PHA03247 2769 PAPPAAPAAGPPRRLT 2784
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
18-354 |
6.08e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.16 E-value: 6.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 18 PGYQGYQQPAYGGQPlpgvphtqYGAYNGPMPGYQQPVPPQgsvrALPTSGAPPPASGTSLPSGH----------QGYSQ 87
Cdd:PHA03247 2475 PGAPVYRRPAEARFP--------FAAGAAPDPGGGGPPDPD----APPAPSRLAPAILPDEPVGEpvhprmltwiRGLEE 2542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 88 FGQGDVqNGIPTSTAPMQRPPASQPFLPGSAPAP-VSQPSTFQQYGPPPCSVQQLSnhmaGMTIGSTSVSAPPPAglgyg 166
Cdd:PHA03247 2543 LASDDA-GDPPPPLPPAAPPAAPDRSVPPPRPAPrPSEPAVTSRARRPDAPPQSAR----PRAPVDDRGDPRGPA----- 2612
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 167 PPTSVPPVSGsfsatgsglytpytaspgppppsvpqglPLAQPPFSGQPVPTQrLPTEVPGFAPPPPATGIGASsypppt 246
Cdd:PHA03247 2613 PPSPLPPDTH----------------------------APDPPPPSPSPAANE-PDPHPPPTVPPPERPRDDPA------ 2657
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 247 GAPRPPPMPGPPLSGQTVAGPPMSQPNHVSSPPP--PLTlSGPHPGPPMSGPPPPTHPPQPGYQMQQNGSFGQVRGPQPN 324
Cdd:PHA03247 2658 PGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTvgSLT-SLADPPPPPPTPEPAPHALVSATPLPPGPAAARQASPALP 2736
|
330 340 350
....*....|....*....|....*....|...
gi 971402013 325 YGGAYPGTPNYGSQPG---PPPKRLDPDSIPSP 354
Cdd:PHA03247 2737 AAPAPPAVPAGPATPGgpaRPARPPTTAGPPAP 2769
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
11-138 |
6.51e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 43.99 E-value: 6.51e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 11 PPYGQPQPGY---QGYQQPAYGGQPlPGVPHTQY---GAYNGPMPGYQQPVPPQ-----------GSVRALPTSGaPPPA 73
Cdd:pfam03154 407 PPSAHPPPLQlmpQSQQLPPPPAQP-PVLTQSQSlppPAASHPPTSGLHQVPSQspfpqhpfvpgGPPPITPPSG-PPTS 484
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 971402013 74 SGTSLPSGHQ--GYSQFGQGDVQNGIPTSTAPMQ--RPPASQPFLPGSAPAPVSQPStfqqygPPPCSV 138
Cdd:pfam03154 485 TSSAMPGIQPpsSASVSSSGPVPAAVSCPLPPVQikEEALDEAEEPESPPPPPRSPS------PEPTVV 547
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
46-235 |
2.00e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.28 E-value: 2.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 46 GPMPGYQQPVPPQGSVRALPTSGAPPPASGTSLPSGHQGYSQFGQGDVQNGIPTSTAPMQRPPASQPFLPGSAPAPVSQP 125
Cdd:PRK07764 599 GPPAPASSGPPEEAARPAAPAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWPAKAGGAAP 678
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 126 StfqQYGPPPCSVQQLSNHMAGMTIGSTSVSAPPPAGLGYGPPTSVPPVSGSFSATGsglytPYTASPGPPPPSVpqGLP 205
Cdd:PRK07764 679 A---APPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPS-----PAADDPVPLPPEP--DDP 748
|
170 180 190
....*....|....*....|....*....|
gi 971402013 206 LAQPPFSGQPVPTQRLPTEVPGFAPPPPAT 235
Cdd:PRK07764 749 PDPAGAPAQPPPPPAPAPAAAPAAAPPPSP 778
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
12-356 |
3.54e-03 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 41.59 E-value: 3.54e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 12 PYGQPQPGYQG---YQQPAYGGQPLPGVPHTQYGAYNGPMPGYQQP------------VPPQGSVRALPTSGAPPPASGT 76
Cdd:PHA03378 457 PPTQPLEGPTGplsVQAPLEPWQPLPHPQVTPVILHQPPAQGVQAHgsmldllekddeDMEQRVMATLLPPSPPQPRAGR 536
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 77 SLPSGHQgysqfGQGDVQNGIPTSTAPMQRPPASQPFLPGSAPAPVSQPSTFQ------QYGPPPCSVQQLSNHMAGMTI 150
Cdd:PHA03378 537 RAPCVYT-----EDLDIESDEPASTEPVHDQLLPAPGLGPLQIQPLTSPTTSQlassapSYAQTPWPVPHPSQTPEPPTT 611
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 151 GS--TSVSAPPPAGLGYGPPTSVPPVSGSFSATGSGLYTPYTASPGPPPPSVPQGLPLAQPPFsgQPVP----TQRLPTE 224
Cdd:PHA03378 612 QShiPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTPHQPPQVEITPYKPTWTQIGHIPY--QPSPtganTMLPIQW 689
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 225 VPGFAPPPPATgigassyppptgaprpppmpGPPLSGQTVAGPPMSQPNHVSSP-PPPLTLSGPHPGPPMSGPPPPTHPP 303
Cdd:PHA03378 690 APGTMQPPPRA--------------------PTPMRPPAAPPGRAQRPAAATGRaRPPAAAPGRARPPAAAPGRARPPAA 749
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 971402013 304 QPGYQMQQNGSFGQVRGPQpnyggAYPGTPNYGSQP-GPPPKRLDPDSIPSPIQ 356
Cdd:PHA03378 750 APGRARPPAAAPGRARPPA-----AAPGAPTPQPPPqAPPAPQQRPRGAPTPQP 798
|
|
| dnaA |
PRK14086 |
chromosomal replication initiator protein DnaA; |
9-162 |
3.66e-03 |
|
chromosomal replication initiator protein DnaA;
Pssm-ID: 237605 [Multi-domain] Cd Length: 617 Bit Score: 41.35 E-value: 3.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 9 AGPPYGQP--QPGYQGYQQPAYGGQPLPGVPHTQ--------------------YGAYN-----GPMPGYQQPVPPQgSV 61
Cdd:PRK14086 92 AGEPAPPPphARRTSEPELPRPGRRPYEGYGGPRaddrppglprqdqlptarpaYPAYQqrpepGAWPRAADDYGWQ-QQ 170
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 62 RALPTSGAPPPASGTSLPSGHQGYSQFGQGDVQNGIPTSTAPMQRPPASQPF-----LPGSAPAPVSQPSTFQQYGPPPC 136
Cdd:PRK14086 171 RLGFPPRAPYASPASYAPEQERDREPYDAGRPEYDQRRRDYDHPRPDWDRPRrdrtdRPEPPPGAGHVHRGGPGPPERDD 250
|
170 180
....*....|....*....|....*.
gi 971402013 137 SVQQLSNHMAGMTIGSTSVSAPPPAG 162
Cdd:PRK14086 251 APVVPIRPSAPGPLAAQPAPAPGPGE 276
|
|
| Glutenin_hmw |
pfam03157 |
High molecular weight glutenin subunit; Members of this family include high molecular weight ... |
14-215 |
3.84e-03 |
|
High molecular weight glutenin subunit; Members of this family include high molecular weight subunits of glutenin. This group of gluten proteins is thought to be largely responsible for the elastic properties of gluten, and hence, doughs. Indeed, glutenin high molecular weight subunits are classified as elastomeric proteins, because the glutenin network can withstand significant deformations without breaking, and return to the original conformation when the stress is removed. Elastomeric proteins differ considerably in amino acid sequence, but they are all polymers whose subunits consist of elastomeric domains, composed of repeated motifs, and non-elastic domains that mediate cross-linking between the subunits. The elastomeric domain motifs are all rich in glycine residues in addition to other hydrophobic residues. High molecular weight glutenin subunits have an extensive central elastomeric domain, flanked by two terminal non-elastic domains that form disulphide cross-links. The central elastomeric domain is characterized by the following three repeated motifs: PGQGQQ, GYYPTS[P/L]QQ, GQQ. It possesses overlapping beta-turns within and between the repeated motifs, and assumes a regular helical secondary structure with a diameter of approx. 1.9 nm and a pitch of approx. 1.5 nm.
Pssm-ID: 367362 [Multi-domain] Cd Length: 786 Bit Score: 41.47 E-value: 3.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 14 GQPQPGY--QGYQQPAYGGQPLPGVPHTQYG-AYNGPMPGYQQPvPPQGSVRALPTSGAPP--------PASGTSLPSGH 82
Cdd:pfam03157 363 GQGQPGYypTSQQQPQQGQQPEQGQQGQQQGqGQQGQQPGQGQQ-PGQGQPGYYPTSPQQSgqgqpgyyPTSPQQSGQGQ 441
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 83 Q-------GYSQFGQGD-----VQNGIPTSTAPMQRPPASQpflPGSAPAPVSQPSTFQQYGPPPCSVQQLSNHMAgmti 150
Cdd:pfam03157 442 QpgqgqqpGQEQPGQGQqpgqgQQGQQPGQPEQGQQPGQGQ---PGYYPTSPQQSGQGQQLGQWQQQGQGQPGYYP---- 514
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971402013 151 gsTSVSAPPPAGLGYGPPTSVPPVSGSFSATgsgLYTPYTASPGPPPPSVPQGLPLAQPPFSGQP 215
Cdd:pfam03157 515 --TSPLQPGQGQPGYYPTSPQQPGQGQQLGQ---LQQPTQGQQGQQSGQGQQGQQPGQGQQGQQP 574
|
|
| PHA02682 |
PHA02682 |
ORF080 virion core protein; Provisional |
64-237 |
5.27e-03 |
|
ORF080 virion core protein; Provisional
Pssm-ID: 177464 [Multi-domain] Cd Length: 280 Bit Score: 40.23 E-value: 5.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 64 LPTSGAPPPASGTSLPSGHQGYSQFGQGdVQNGIPTSTAPMQRPPASQPFLPgSAPAPVSQPSTFQQYGPPPCSvqqlsn 143
Cdd:PHA02682 34 IPAPAAPCPPDADVDPLDKYSVKEAGRY-YQSRLKANSACMQRPSGQSPLAP-SPACAAPAPACPACAPAAPAP------ 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 144 hmagmtigSTSVSAPPPAGLGYGPPTSVPPVSGSFSATGSGLYTPYTAS-PGPPPPSVPQGLPLAQPPFSGQPVPTQRLP 222
Cdd:PHA02682 106 --------AVTCPAPAPACPPATAPTCPPPAVCPAPARPAPACPPSTRQcPPAPPLPTPKPAPAAKPIFLHNQLPPPDYP 177
|
170
....*....|....*.
gi 971402013 223 -TEVPGFAPPPPATGI 237
Cdd:PHA02682 178 aASCPTIETAPAASPV 193
|
|
| GGN |
pfam15685 |
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the ... |
54-379 |
5.81e-03 |
|
Gametogenetin; GGN is a family of proteins largely found in mammals. It reacts with POG in the maturation of sperm and is expressed virtually only in the testis. It is found to be associated with the intracellular membrane, binds with GGNBP1 and may be involved in vesicular trafficking.
Pssm-ID: 434857 [Multi-domain] Cd Length: 668 Bit Score: 40.91 E-value: 5.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 54 PV-PPQGSVRALPTSGAPPPASGTSLPS----------------GHQGYSQFGQGDvqngiPTSTAPMQRPPASQPFLPG 116
Cdd:pfam15685 83 PVtPPPEEAAAAAVSTAPPPAVGSLLPApskwrkptgtavarirGLLEASHRGQGD-----PLSLRPLLPLLPRQLIEKD 157
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 117 SAP-APVSQPSTF---QQYGPPPCSVQQLSN--------------------HMA-GMTIGSTSVSAPPPAGLG------- 164
Cdd:pfam15685 158 PAPgAPAPPPPTPlepRKPPPLPPSDRQPPNrgitpalatsatsptdsqakHIAeGKTAGGACGGAPPQAGEGemarfaa 237
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 165 --------------YGPPTSVPPVSGSFSAT-------GSGLYTpyTASPGPPPPSVPQGlPLaqPPfsGQPvptqRLPT 223
Cdd:pfam15685 238 sesglsllckvtfkSAAPLCPAAASGPLAAKaslggggGGGLFA--ASGAISCAEVLKQG-PL--AP--GAA----RPLG 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 224 EVPGFAPPPPAtGIGassyppptgaprpppmpgpplSGQTVAGPPMSQPNHVSS-PPPPLTLSGPHPGPPMSGPPPPTHP 302
Cdd:pfam15685 307 EVPRAALETEG-GEG---------------------DGEGCSGGPAAPASHARAlPPPAYTTFPGSKPKFDWVSPPDGPE 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 303 PqpgyQMQQNGSFGQVRGPQPNYGG-----AYPGTPNYGSQPGPPPKRLDPDSIPSPIQVIEDDRNNRGSEPFVTGVRGQ 377
Cdd:pfam15685 365 R----HFRFNGAGGGIGAPRRRAAAlsgpwGSPPPPPGKAHPIPGPRRPAPALLAPPMFIFPAPTNGEPVRPGPPAPQAL 440
|
..
gi 971402013 378 VP 379
Cdd:pfam15685 441 LP 442
|
|
| PRK12727 |
PRK12727 |
flagellar biosynthesis protein FlhF; |
99-285 |
6.25e-03 |
|
flagellar biosynthesis protein FlhF;
Pssm-ID: 237182 [Multi-domain] Cd Length: 559 Bit Score: 40.36 E-value: 6.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 99 TSTAPMQRPPASQPFLPGSAPAPVSQPSTFQQYGPPPCSVQQLSNHM-AGMTI-GSTSVSAPPPAGLGYGPPTSVPPVSG 176
Cdd:PRK12727 62 TPATAAAPAPAPQAPTKPAAPVHAPLKLSANANMSQRQRVASAAEDMiAAMALrQPVSVPRQAPAAAPVRAASIPSPAAQ 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 177 SFSATGSGLYTPYTASPGPPPPSVPQGLPLAQPPFSGQPVPtqrlPTEVPGFAPPPPATGIGASSYPPPTGAPRPPPMPG 256
Cdd:PRK12727 142 ALAHAAAVRTAPRQEHALSAVPEQLFADFLTTAPVPRAPVQ----APVVAAPAPVPAIAAALAAHAAYAQDDDEQLDDDG 217
|
170 180 190
....*....|....*....|....*....|
gi 971402013 257 PPL-SGQTVAGPPMSQPNHVSSPPPPLTLS 285
Cdd:PRK12727 218 FDLdDALPQILPPAALPPIVVAPAAPAALA 247
|
|
| PPE |
COG5651 |
PPE-repeat protein [Function unknown]; |
63-285 |
7.42e-03 |
|
PPE-repeat protein [Function unknown];
Pssm-ID: 444372 [Multi-domain] Cd Length: 385 Bit Score: 39.88 E-value: 7.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 63 ALPTSGAPPPASGTslPSGHQGYSQFG--QGDVQNGIPTSTAPMQRPPASQPFLPGSAPAPVSqpstfqqygPPPCSVQQ 140
Cdd:COG5651 163 ALTPFTQPPPTITN--PGGLLGAQNAGsgNTSSNPGFANLGLTGLNQVGIGGLNSGSGPIGLN---------SGPGNTGF 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971402013 141 LSNHMAGMTIGSTSVSAPPPAGLGYGPPTSVPPVSGSFSATGSGLYTPYTASPGPPPPSVPQGLPLAQPPFSGQPVPTQR 220
Cdd:COG5651 232 AGTGAAAGAAAAAAAAAAAAGAGASAALASLAATLLNASSLGLAATAASSAATNLGLAGSPLGLAGGGAGAAAATGLGLG 311
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971402013 221 LPTEVPGFAPPPPATGIGASSYPPPTGAPRPPPMPGPPLSGQTVAGPPMSQPNHVSSPPPPLTLS 285
Cdd:COG5651 312 AGGAAGAAGATGAGAALGAGAAAAAAGAAAGAGAAAAAAAGGAGGGGGGALGAGGGGGSAGAAAG 376
|
|
| |
