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Conserved domains on  [gi|2024357538|ref|XP_015149959|]
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transcription factor E4F1 isoform X2 [Gallus gallus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 501-563 4.60e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.72  E-value: 4.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357538 501 GHRRVHSDERPYSCP--KCGKRYKTKNAQQVHfRTH--------------------LEDKPYVCQYCSRGFREKGSLVRH 558
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 2024357538 559 IRHHT 563
Cdd:COG5189   418 RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
554-578 5.49e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.49e-05
                          10        20
                  ....*....|....*....|....*
gi 2024357538 554 SLVRHIRHHTGEKPFKCYKCGRGFA 578
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-248 1.42e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.42e-04
                          10        20
                  ....*....|....*....|....
gi 2024357538 225 SLIRHHRRHTDERPYKCKKCGKSF 248
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-306 2.97e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357538 182 RYVCELCQKTFKTASILKAHM-ITHSSRKDYE---C--KLCGTSFRTKGSLIRHHRRHTDERPYKCKkcgksfrESGALT 255
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLrSVNHSGESLKpfsCpySLCGKLFSRNDALKRHILLHTSISPAKEK-------LLNSSS 361

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2024357538 256 RHLKSLTPCTEKIRFNvNKEIVVNKDDLPTGSCSSNSETVPSIASESIETS 306
Cdd:COG5048   362 KFSPLLNNEPPQSLQQ-YKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITH 411
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 456-478 8.39e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.39e-03
                          10        20
                  ....*....|....*....|...
gi 2024357538 456 FKCEECGKEFTKGYLLKKHQEVH 478
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 super family cl26169
hypothetical protein
 428-474 9.15e-03

hypothetical protein


The actual alignment was detected with superfamily member PHA00733:

Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 9.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2024357538 428 YVCPHCNEAFSEAASLETHIKGHLDYKpfKCEECGKEFTK-----GYLLKKH 474
Cdd:PHA00733   74 YVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNtdstlDHVCKKH 123
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 501-563 4.60e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.72  E-value: 4.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357538 501 GHRRVHSDERPYSCP--KCGKRYKTKNAQQVHfRTH--------------------LEDKPYVCQYCSRGFREKGSLVRH 558
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 2024357538 559 IRHHT 563
Cdd:COG5189   418 RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
554-578 5.49e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.49e-05
                          10        20
                  ....*....|....*....|....*
gi 2024357538 554 SLVRHIRHHTGEKPFKCYKCGRGFA 578
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-248 1.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.42e-04
                          10        20
                  ....*....|....*....|....
gi 2024357538 225 SLIRHHRRHTDERPYKCKKCGKSF 248
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-306 2.97e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357538 182 RYVCELCQKTFKTASILKAHM-ITHSSRKDYE---C--KLCGTSFRTKGSLIRHHRRHTDERPYKCKkcgksfrESGALT 255
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLrSVNHSGESLKpfsCpySLCGKLFSRNDALKRHILLHTSISPAKEK-------LLNSSS 361

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2024357538 256 RHLKSLTPCTEKIRFNvNKEIVVNKDDLPTGSCSSNSETVPSIASESIETS 306
Cdd:COG5048   362 KFSPLLNNEPPQSLQQ-YKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITH 411
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 211-233 3.01e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 3.01e-04
                          10        20
                  ....*....|....*....|...
gi 2024357538 211 YECKLCGTSFRTKGSLIRHHRRH 233
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 511-587 7.81e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.63  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357538 511 PYSCPKCGKRYKTKNAQQVHFRTH------LEDKPYVCQ--YCSRGFREKGSLVRHIR-HHTGEKPFKCYKCGRGFAEHG 581
Cdd:pfam15909   1 PCSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSalSCTETFPSMQELVAHSKlHYKPNRYFKCENCLLRFRTHR 80


                  ....*.
gi 2024357538 582 TLNRHL 587
Cdd:pfam15909  81 SLFKHL 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 456-478 8.39e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.39e-03
                          10        20
                  ....*....|....*....|...
gi 2024357538 456 FKCEECGKEFTKGYLLKKHQEVH 478
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 428-474 9.15e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 9.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2024357538 428 YVCPHCNEAFSEAASLETHIKGHLDYKpfKCEECGKEFTK-----GYLLKKH 474
Cdd:PHA00733   74 YVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNtdstlDHVCKKH 123
 
Name Accession Description Interval E-value
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 501-563 4.60e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.72  E-value: 4.60e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357538 501 GHRRVHSDERPYSCP--KCGKRYKTKNAQQVHfRTH--------------------LEDKPYVCQYCSRGFREKGSLVRH 558
Cdd:COG5189   339 SRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLHghqnqklhenpspekmnifsAKDKPYRCEVCDKRYKNLNGLKYH 417


                  ....*
gi 2024357538 559 IRHHT 563
Cdd:COG5189   418 RKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
554-578 5.49e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 5.49e-05
                          10        20
                  ....*....|....*....|....*
gi 2024357538 554 SLVRHIRHHTGEKPFKCYKCGRGFA 578
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-248 1.42e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.42e-04
                          10        20
                  ....*....|....*....|....
gi 2024357538 225 SLIRHHRRHTDERPYKCKKCGKSF 248
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
182-306 2.97e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357538 182 RYVCELCQKTFKTASILKAHM-ITHSSRKDYE---C--KLCGTSFRTKGSLIRHHRRHTDERPYKCKkcgksfrESGALT 255
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLrSVNHSGESLKpfsCpySLCGKLFSRNDALKRHILLHTSISPAKEK-------LLNSSS 361

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 2024357538 256 RHLKSLTPCTEKIRFNvNKEIVVNKDDLPTGSCSSNSETVPSIASESIETS 306
Cdd:COG5048   362 KFSPLLNNEPPQSLQQ-YKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITH 411
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 211-233 3.01e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 3.01e-04
                          10        20
                  ....*....|....*....|...
gi 2024357538 211 YECKLCGTSFRTKGSLIRHHRRH 233
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 239-260 7.38e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 7.38e-03
                          10        20
                  ....*....|....*....|..
gi 2024357538 239 YKCKKCGKSFRESGALTRHLKS 260
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRT 22
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 511-587 7.81e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.63  E-value: 7.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2024357538 511 PYSCPKCGKRYKTKNAQQVHFRTH------LEDKPYVCQ--YCSRGFREKGSLVRHIR-HHTGEKPFKCYKCGRGFAEHG 581
Cdd:pfam15909   1 PCSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSalSCTETFPSMQELVAHSKlHYKPNRYFKCENCLLRFRTHR 80


                  ....*.
gi 2024357538 582 TLNRHL 587
Cdd:pfam15909  81 SLFKHL 86
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 456-478 8.39e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.39e-03
                          10        20
                  ....*....|....*....|...
gi 2024357538 456 FKCEECGKEFTKGYLLKKHQEVH 478
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 428-474 9.15e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 9.15e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2024357538 428 YVCPHCNEAFSEAASLETHIKGHLDYKpfKCEECGKEFTK-----GYLLKKH 474
Cdd:PHA00733   74 YVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNtdstlDHVCKKH 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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