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Conserved domains on  [gi|971428972|ref|XP_015152472|]
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proton-associated sugar transporter A isoform X4 [Gallus gallus]

Protein Classification

SLC45 family MFS transporter( domain architecture ID 13022743)

SLC45 (solute carrier 45) family major facilitator superfamily (MFS) transporter facilitates the transport of sugars such as sucrose, glucose, and maltose into the cell, with the concomitant uptake of protons (symport system)

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0016020|GO:0015293
PubMed:  26098515|26758938|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 88-727 1.48e-105

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 329.59  E-value: 1.48e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  88 LLFNGCILFGLEFSYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGAL 167
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 168 FGLSLMLNGRDIGSALSDtvNNHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDRGLNIHALLAGLGGGFGY 247
Cdd:cd17313   81 LGLILIPNAADIGLALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 248 VIGGIHWDKTSFGKAVGGQLRVIYVFTSIILTITTVLTLISIPERPLGSfsrkkkvmkspslplppspplffeegvnenf 327
Cdd:cd17313  159 LLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSP------------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 328 asrnsdhlyasftspvsplspltpkygsfvsrdnsltginefassfgtsnidsvlidcftgghssylalpaslprqpvsv 407
Cdd:cd17313      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 408 sfprvpdgcyqqengilEQGERSIIPGPDGEALRVGSLDAIKPRssgilkrpqslaipdivtghcpessrrrnvtfsqqv 487
Cdd:cd17313  208 -----------------EAGEHSENPSLGEVLKSLLKLLKIMPR------------------------------------ 234

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 488 anilldgvkyeselngsgetseqplSMRLLCstichmpralrnlcINHFLGWLSFEGMLLFYTDFMGEVVFEGNPKAphn 567
Cdd:cd17313  235 -------------------------SLLRLL--------------LVIFFWWIAFFPFELFFTDYMGEEVYHGTSAA--- 272

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 568 sdeYQKYNAGVTMGCWGMCIYAFSAAFYSAALEKLEERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFA 647
Cdd:cd17313  273 ---SSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWA 349

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 648 TLCTLPYSLLCDYyqscefagshTEGTRRGMGVDISLLSCQYFLAQILVALAMGPL--TTAVGSASGTMYFASLVSFLGC 725
Cdd:cd17313  350 TININPYPLVSDY----------HSESGRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGA 419


                 ..
gi 971428972 726 LF 727
Cdd:cd17313  420 LF 421
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 88-727 1.48e-105

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 329.59  E-value: 1.48e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  88 LLFNGCILFGLEFSYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGAL 167
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 168 FGLSLMLNGRDIGSALSDtvNNHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDRGLNIHALLAGLGGGFGY 247
Cdd:cd17313   81 LGLILIPNAADIGLALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 248 VIGGIHWDKTSFGKAVGGQLRVIYVFTSIILTITTVLTLISIPERPLGSfsrkkkvmkspslplppspplffeegvnenf 327
Cdd:cd17313  159 LLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSP------------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 328 asrnsdhlyasftspvsplspltpkygsfvsrdnsltginefassfgtsnidsvlidcftgghssylalpaslprqpvsv 407
Cdd:cd17313      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 408 sfprvpdgcyqqengilEQGERSIIPGPDGEALRVGSLDAIKPRssgilkrpqslaipdivtghcpessrrrnvtfsqqv 487
Cdd:cd17313  208 -----------------EAGEHSENPSLGEVLKSLLKLLKIMPR------------------------------------ 234

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 488 anilldgvkyeselngsgetseqplSMRLLCstichmpralrnlcINHFLGWLSFEGMLLFYTDFMGEVVFEGNPKAphn 567
Cdd:cd17313  235 -------------------------SLLRLL--------------LVIFFWWIAFFPFELFFTDYMGEEVYHGTSAA--- 272

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 568 sdeYQKYNAGVTMGCWGMCIYAFSAAFYSAALEKLEERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFA 647
Cdd:cd17313  273 ---SSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWA 349

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 648 TLCTLPYSLLCDYyqscefagshTEGTRRGMGVDISLLSCQYFLAQILVALAMGPL--TTAVGSASGTMYFASLVSFLGC 725
Cdd:cd17313  350 TININPYPLVSDY----------HSESGRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGA 419


                 ..
gi 971428972 726 LF 727
Cdd:cd17313  420 LF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 81-223 3.58e-20

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 94.49  E-value: 3.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972   81 PRRSFLELLFNGCilfGLEFSYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFIL 160
Cdd:TIGR01301   2 PLRKLLRVASVAA---GVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIA 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971428972  161 VLAVGALFGLSLMLNGRDIGSALSDTVN--NHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVC 223
Cdd:TIGR01301  79 AGAALVAFAVILIGFAADIGHLFGDNLDkkTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLT 143
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
80-174 2.34e-14

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 76.09  E-value: 2.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  80 QPRRSFLELLFNGCILFGLEFSYAMETAYVTPVLLQ-MGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPF 158
Cdd:COG2211    4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPW 83

                         90
                 ....*....|....*.
gi 971428972 159 ILVLAVgaLFGLSLML 174
Cdd:COG2211   84 ILIGAI--PLALSFVL 97
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 90-228 7.44e-06

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 49.23  E-value: 7.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972   90 FNGCILFGLEFSYAMETAYVTPVLLQ-MGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALF 168
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDvLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  169 GLSLMLNGRDIGSALSDTvnnhkWGIVLTVCGVVLMDFSadsaDNPSHAYMMDVCSPMDQ 228
Cdd:pfam13347  81 SFILLFTPPELGRAPLFI-----WLLATYILLRIAYTFF----EIPYWSLGPELTRDYDE 131
PRK09669 PRK09669
putative symporter YagG; Provisional
 117-174 6.37e-03

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 39.71  E-value: 6.37e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 971428972 117 GLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGalFGLSLML 174
Cdd:PRK09669  41 GLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPYLLWFAIP--FGVVCLL 96
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 88-727 1.48e-105

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 329.59  E-value: 1.48e-105
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  88 LLFNGCILFGLEFSYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGAL 167
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 168 FGLSLMLNGRDIGSALSDtvNNHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDRGLNIHALLAGLGGGFGY 247
Cdd:cd17313   81 LGLILIPNAADIGLALGD--GPRTWALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMGGLGGVLGY 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 248 VIGGIHWDKTSFGKAVGGQLRVIYVFTSIILTITTVLTLISIPERPLGSfsrkkkvmkspslplppspplffeegvnenf 327
Cdd:cd17313  159 LLGAILWDHNWFGFALGGNLKVPFYIGAIILLVCVLVTLFFVKEPPLSP------------------------------- 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 328 asrnsdhlyasftspvsplspltpkygsfvsrdnsltginefassfgtsnidsvlidcftgghssylalpaslprqpvsv 407
Cdd:cd17313      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 408 sfprvpdgcyqqengilEQGERSIIPGPDGEALRVGSLDAIKPRssgilkrpqslaipdivtghcpessrrrnvtfsqqv 487
Cdd:cd17313  208 -----------------EAGEHSENPSLGEVLKSLLKLLKIMPR------------------------------------ 234

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 488 anilldgvkyeselngsgetseqplSMRLLCstichmpralrnlcINHFLGWLSFEGMLLFYTDFMGEVVFEGNPKAphn 567
Cdd:cd17313  235 -------------------------SLLRLL--------------LVIFFWWIAFFPFELFFTDYMGEEVYHGTSAA--- 272

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 568 sdeYQKYNAGVTMGCWGMCIYAFSAAFYSAALEKLEERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFA 647
Cdd:cd17313  273 ---SSHYGAGVRMGAWGLLIFSLAFLIFSLPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWA 349

                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 648 TLCTLPYSLLCDYyqscefagshTEGTRRGMGVDISLLSCQYFLAQILVALAMGPL--TTAVGSASGTMYFASLVSFLGC 725
Cdd:cd17313  350 TININPYPLVSDY----------HSESGRGQGTDTGLLNLAISLAQILVSLLAGPIidVKGYGTVFPVAAVASFLSLVGA 419


                 ..
gi 971428972 726 LF 727
Cdd:cd17313  420 LF 421
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 81-223 3.58e-20

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 94.49  E-value: 3.58e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972   81 PRRSFLELLFNGCilfGLEFSYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFIL 160
Cdd:TIGR01301   2 PLRKLLRVASVAA---GVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIA 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 971428972  161 VLAVGALFGLSLMLNGRDIGSALSDTVN--NHKWGIVLTVCGVVLMDFSADSADNPSHAYMMDVC 223
Cdd:TIGR01301  79 AGAALVAFAVILIGFAADIGHLFGDNLDkkTKPRAIIVFVVGFWILDVANNMLQGPCRAFLADLT 143
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
80-174 2.34e-14

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 76.09  E-value: 2.34e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  80 QPRRSFLELLFNGCILFGLEFSYAMETAYVTPVLLQ-MGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPF 158
Cdd:COG2211    4 KKKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDvLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPW 83

                         90
                 ....*....|....*.
gi 971428972 159 ILVLAVgaLFGLSLML 174
Cdd:COG2211   84 ILIGAI--PLALSFVL 97
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 92-293 1.88e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 53.97  E-value: 1.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  92 GCILFGLEFSYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFILVLAVGALFGLS 171
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGRRPVLLLGLLLFALGALL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 172 LMLNgrdigsalsdtvnnhkWGIVLTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDRGLNIHALLAGLGGGFGYVIGG 251
Cdd:cd06174   78 FAFA----------------PSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG 141

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 971428972 252 IHWDKTSFGkavggqLRVIYVFTSIILTITTVLTLISIPERP 293
Cdd:cd06174  142 ILASSLGFG------WRAVFLIAAALALLAAILLLLVVPDPP 177
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 90-228 7.44e-06

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 49.23  E-value: 7.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972   90 FNGCILFGLEFSYAMETAYVTPVLLQ-MGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALF 168
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDvLGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  169 GLSLMLNGRDIGSALSDTvnnhkWGIVLTVCGVVLMDFSadsaDNPSHAYMMDVCSPMDQ 228
Cdd:pfam13347  81 SFILLFTPPELGRAPLFI-----WLLATYILLRIAYTFF----EIPYWSLGPELTRDYDE 131
BtlA COG2270
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ...
 119-230 1.48e-05

MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];


Pssm-ID: 441871 [Multi-domain]  Cd Length: 424  Bit Score: 48.23  E-value: 1.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 119 PDQLYGMVWFISPILGFLLQPLLGAWSDRCtsrfGRRRPFILV---LAVGALFGLSLMLNGrdigsalsdtvnnhkwGIV 195
Cdd:COG2270   50 ATALWGYALAIAGLLVALLAPVLGAIADRS----GRKKPFLAFftlLGVLATAALFFVAPG----------------GLW 109

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 971428972 196 LTVCGVVLMDFSADSADNPSHAYMMDVCSPMDQDR 230
Cdd:COG2270  110 LGLLLFVLANIGFEGSLVFYNAFLPDIATPEEIGR 144
MFS_1 pfam07690
Major Facilitator Superfamily;
82-201 9.12e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 45.49  E-value: 9.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972   82 RRSFLELLFNGCILFgleFSYAMETAYVTPVLLQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFILV 161
Cdd:pfam07690 199 RDPVLWLLLALLLFG---FAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSD----RLGRRRRLLLA 271

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 971428972  162 LAVGALFGLSLMLngrdigsaLSDTVNNHKWGIVLTVCGV 201
Cdd:pfam07690 272 LLLLILAALGLLL--------LSLTLSSLWLLLALLLLGF 303
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 82-225 1.24e-04

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 44.87  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  82 RRSFLELLFNGCIL--FGLEFSYAMETAYVTPVL-----LQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGR 154
Cdd:cd17325  189 RSGLRLLLRDRRLLalFLAIFVLAFAFGALEPFLplyaaELGGLSPAQIGLLFGAQGLASALSQPPAGKLSD----RIGR 264

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971428972 155 RRPFILVLAVGALFGLSLmlngrdigsALSDTVnnhkWGIVLtvcGVVLMDFSADSADNPSHAYMMDVCSP 225
Cdd:cd17325  265 KPLILIGLLLSAVALLLL---------PLATSF----WLLLL---LLALLGLGLGLVFPATLALLADIVPP 319
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 90-173 1.61e-04

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 44.90  E-value: 1.61e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  90 FNGCILFGLEFSYAMEtaYVTPVllqMGLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGALFG 169
Cdd:cd17332    9 FGNNLIFQIVSTYLLF--FYTDV---LGLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIPLALL 83


                 ....
gi 971428972 170 LSLM 173
Cdd:cd17332   84 FVLL 87
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 601-728 4.09e-04

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 43.33  E-value: 4.09e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 601 KLEERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFATLctLPYSLLcdyyqsceFAGSHTEGTRRGMGv 680
Cdd:cd17473  255 RLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLL--LPTLNS--------WAMSLVPPELRGRA- 323

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 971428972 681 dISLLSCQYFLAQILVALAMGPLTTAVGSASGTMYFASLVSFLGCLFS 728
Cdd:cd17473  324 -MGIVTSAFFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVL 370
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 88-174 1.11e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.78  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  88 LLFNGCILFGLefsyaMETAYVT--PV-LLQMGLPDQlyGMVWFISPIL--GFLLQPLLGAWSDrctsRFGRRRPFILVL 162
Cdd:cd17477  192 LALLGAFVAGF-----LEGAFYSllPLyGLRLGLSVA--QAALLLAAFVlgGLLLQWPLGWLAD----RFDRRRVLLGCA 260

                         90
                 ....*....|..
gi 971428972 163 AVGALFGLSLML 174
Cdd:cd17477  261 LLGALAALLLPL 272
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
 94-179 1.31e-03

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 41.74  E-value: 1.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  94 ILFGLEFSYAMetAYVTPVLlqmGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFIL--VLAVGALFGLS 171
Cdd:cd17369  242 VLFYLFTTFAL--SYATQTL---GVDRSTVLLAVLIASVVAAITIPLFGWLSD----RVGRRPVYLAgaLLAALFAFPFF 312


                 ....*...
gi 971428972 172 LMLNGRDI 179
Cdd:cd17369  313 WLLDTGST 320
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 526-728 1.36e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.64  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 526 RALRNLCINHFLGWLSFEGMLLFYTDFMGEVVfegnpkapHNSDEYQKYNAGVTMGC--WGMCIYAFSaafysaalekLE 603
Cdd:cd06174  203 PGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLG--------GLSVAVAGLLLSLFGLAgaLGSLLLGLL----------SD 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 604 ERFSTRTLYFIAYLAFGLGTGLATLSRNIYIVLSLCTTYGILFATLCTLPYSLLCDYYQscefagshtegtRRGMGVDIS 683
Cdd:cd06174  265 RLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFP------------PEIRGTAFG 332

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 971428972 684 LLSCQYFLAQILVALAMGPLTTAVGSASGTMYFASLVSFLGCLFS 728
Cdd:cd06174  333 LLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILL 377
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
94-174 1.36e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 1.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  94 ILFGLEFSYAMETAYVTPVL----LQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGRRRPFILVLAVGALFG 169
Cdd:COG2814   14 ALALGAFLSGLGIGIVLPALpliaADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD----RFGRRRVLLLGLLLFALGS 89


                 ....*
gi 971428972 170 LSLML 174
Cdd:COG2814   90 LLCAL 94
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
605-733 1.95e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 1.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972 605 RFSTRTLYFIAYLAFGLGTGLATLSR--NIYIVLSLCTTYGILFATLCTLPYSLL---CDYyqscefaGSHTEGTRRgMG 679
Cdd:COG2211  290 RFGKKKAFIIGLLLAALGLLLLFFLGpgNLWLLLVLAALAGIGLGAILVLPWAMLadvVDY-------DEWKTGRRR-EG 361

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 971428972 680 VDISLLSCQYFLAQILVALAMGPLTTAVG-------SASGTMYFASLVSFLGCLFSSLCVI 733
Cdd:COG2211  362 LYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqSPSALTGIRLLFFLLPAVLLLLAAL 422
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
76-174 3.69e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 40.34  E-value: 3.69e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  76 FGDLQPRRSFLELLFngcILFGLEFSYAMETAYVTPVLLQ-MGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRFGR 154
Cdd:COG2814  200 LRELLRRPRLLLLLL---LAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVLGALLAGRLAD----RFGR 272

                         90       100
                 ....*....|....*....|
gi 971428972 155 RRPFILVLAVGALfGLSLML 174
Cdd:COG2814  273 RRLLLIGLLLLAL-GLLLLA 291
PRK09669 PRK09669
putative symporter YagG; Provisional
 117-174 6.37e-03

putative symporter YagG; Provisional


Pssm-ID: 236610  Cd Length: 444  Bit Score: 39.71  E-value: 6.37e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 971428972 117 GLPDQLYGMVWFISPILGFLLQPLLGAWSDRCTSRFGRRRPFILVLAVGalFGLSLML 174
Cdd:PRK09669  41 GLSAAIMGTMFLVVRVLDAVTDPLMGALVDRTRTRHGQFRPYLLWFAIP--FGVVCLL 96
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
80-183 8.53e-03

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 39.09  E-value: 8.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  80 QPRRSFLELLFNG-----CILFGLEF-SYAMETAYVTPVL-LQMGLPDQLYGMVWFISPILGFLLQPLLGAWSDrctsRF 152
Cdd:COG2223  193 ASLRDQLEALRDPrfwllSLLYFGTFgSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSD----RI 268

                         90       100       110
                 ....*....|....*....|....*....|.
gi 971428972 153 GRRRPFILVLAVGALFGLSLMLNGRDIGSAL 183
Cdd:COG2223  269 GGRRVLLIVFALMALGLLLLALALGSLWLFL 299
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
88-174 8.93e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.12  E-value: 8.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 971428972  88 LLFNGCILFGLEFSYAMETAYVTPVLlqmGLPDQLYGMVWFISPILGFLLQPLLGAWSDRctsrFGRRRPFILVLAVGAL 167
Cdd:COG2211  234 LLAYLLFFLALALVAALLLYYFKYVL---GLSAALVGLLLALYFLAALLGAPLWPRLAKR----FGKKKAFIIGLLLAAL 306


                 ....*..
gi 971428972 168 FGLSLML 174
Cdd:COG2211  307 GLLLLFF 313
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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