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Conserved domains on  [gi|982947816|ref|XP_015330562|]
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nucleoside diphosphate kinase 7 isoform X4 [Bos taurus]

Protein Classification

NME7 family nucleoside-diphosphate kinase( domain architecture ID 12218339)

NME7 family nucleoside-diphosphate kinase similar to nucleoside diphosphate kinase 7, which plays a major role in the synthesis of nucleoside triphosphates other than ATP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 92-222 1.41e-83

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239878  Cd Length: 131  Bit Score: 251.21  E-value: 1.41e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSKAGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAVCE 171
Cdd:cd04415    1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982947816 172 WKRLLGPANSGLARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:cd04415   81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 238-367 2.07e-75

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239875  Cd Length: 134  Bit Score: 230.21  E-value: 2.07e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 238 NCTtCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGVVSEYNEMVTEMYSGPCVAMEIQQTN 317
Cdd:cd04412    1 NCT-VCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGEN 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 982947816 318 PTMTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:cd04412   80 AVKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLE 129
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 3-91 9.08e-31

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


:

Pssm-ID: 128921  Cd Length: 104  Bit Score: 113.56  E-value: 9.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816     3 HSERFVFIAEWFDPNA--SLFRRYELLFYPGDGSVEMH--DVKN----HRTFLKRTKY--------EDLHLEDLFIGNKV 66
Cdd:smart00676   1 DKKVLRFDAYWEDPVAmfYLIRRFKIYYYLEDDTIEVFepDVRNsgilQGTFLRRQRVpkpppddpEYYHASDLNVGTTI 80

                           90       100
                   ....*....|....*....|....*
gi 982947816    67 NIFSRQLVLLDYgDQYTARQLGSKK 91
Cdd:smart00676  81 NVFGRQFRIYDC-DEFTRNYLESKG 104
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 92-222 1.41e-83

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 251.21  E-value: 1.41e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSKAGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAVCE 171
Cdd:cd04415    1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982947816 172 WKRLLGPANSGLARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:cd04415   81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 238-367 2.07e-75

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 230.21  E-value: 2.07e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 238 NCTtCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGVVSEYNEMVTEMYSGPCVAMEIQQTN 317
Cdd:cd04412    1 NCT-VCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGEN 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 982947816 318 PTMTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:cd04412   80 AVKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLE 129
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 92-227 7.96e-60

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 190.45  E-value: 7.96e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816    92 EKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:smart00562   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 982947816   170 CEWKRLLGPANsglARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFPSSGV 227
Cdd:smart00562  81 KTWRTLMGPTD---PREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESEI 135
NDK pfam00334
Nucleoside diphosphate kinase;
92-227 2.12e-56

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 181.53  E-value: 2.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816   92 EKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 982947816  170 CEWKRLLGPANSGLArtdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFPSSGV 227
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEEEI 135
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 241-367 1.13e-48

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 161.56  E-value: 1.13e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816   241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:smart00562   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEG-KPFFNDLVEFMTSGPVVAMVLEGEDAVK 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 982947816   321 TFREFCGPADPeiaRHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:smart00562  82 TWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAERE 125
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 90-229 2.61e-42

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 145.21  E-value: 2.61e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  90 KKEKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDD 167
Cdd:COG0105    1 AMERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGEN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982947816 168 AVCEWKRLLGPANSGLArtdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFPSSGVCG 229
Cdd:COG0105   81 AVAVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFSEEEIVS 139
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 92-225 3.30e-40

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 139.47  E-value: 3.30e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:PRK00668   2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982947816 170 CEWKRLLGPANSGLArtdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFPSS 225
Cdd:PRK00668  82 AKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDK pfam00334
Nucleoside diphosphate kinase;
241-367 1.12e-35

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 127.60  E-value: 1.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG-KPFFPDLVEFMTSGPVVAMVLEGENAIS 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 982947816  321 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:pfam00334  82 KWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAERE 125
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 3-91 9.08e-31

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 113.56  E-value: 9.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816     3 HSERFVFIAEWFDPNA--SLFRRYELLFYPGDGSVEMH--DVKN----HRTFLKRTKY--------EDLHLEDLFIGNKV 66
Cdd:smart00676   1 DKKVLRFDAYWEDPVAmfYLIRRFKIYYYLEDDTIEVFepDVRNsgilQGTFLRRQRVpkpppddpEYYHASDLNVGTTI 80

                           90       100
                   ....*....|....*....|....*
gi 982947816    67 NIFSRQLVLLDYgDQYTARQLGSKK 91
Cdd:smart00676  81 NVFGRQFRIYDC-DEFTRNYLESKG 104
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 241-362 2.52e-26

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 102.84  E-value: 2.52e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:COG0105    5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKG-KPFFGELVEFMTSGPVVAMVLEGENAVA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 982947816 321 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPE 362
Cdd:COG0105   84 VVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPE 122
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 244-362 1.92e-21

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 89.01  E-value: 1.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 244 IVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTMTFR 323
Cdd:PRK00668   7 IIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKE-KPFFGELVEFMTSGPVVVMVLEGENAIAKVR 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 982947816 324 EFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPE 362
Cdd:PRK00668  86 ELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPE 121
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 92-222 1.41e-83

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 251.21  E-value: 1.41e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSKAGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAVCE 171
Cdd:cd04415    1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 982947816 172 WKRLLGPANSGLARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:cd04415   81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 238-367 2.07e-75

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 230.21  E-value: 2.07e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 238 NCTtCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGVVSEYNEMVTEMYSGPCVAMEIQQTN 317
Cdd:cd04412    1 NCT-VCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGEN 79

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 982947816 318 PTMTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:cd04412   80 AVKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLE 129
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 92-222 1.77e-65

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 204.90  E-value: 1.77e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVS--KAGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:cd00595    1 ERTLALIKPDAVAegLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982947816 170 CEWKRLLGPANSGLARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:cd00595   81 GEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 92-227 7.96e-60

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 190.45  E-value: 7.96e-60
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816    92 EKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:smart00562   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 982947816   170 CEWKRLLGPANsglARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFPSSGV 227
Cdd:smart00562  81 KTWRTLMGPTD---PREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESEI 135
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 241-367 1.02e-59

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 189.87  E-value: 1.02e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGVvSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:cd00595    3 TLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGR-PFFPDLVQFMSSGPVVAMILEKDNAVG 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 982947816 321 TFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:cd00595   82 EWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAARE 128
NDK pfam00334
Nucleoside diphosphate kinase;
92-227 2.12e-56

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 181.53  E-value: 2.12e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816   92 EKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 982947816  170 CEWKRLLGPANSGLArtdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFPSSGV 227
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEEEI 135
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 241-367 1.13e-48

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 161.56  E-value: 1.13e-48
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816   241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:smart00562   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEG-KPFFNDLVEFMTSGPVVAMVLEGEDAVK 81

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 982947816   321 TFREFCGPADPeiaRHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:smart00562  82 TWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAERE 125
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 92-223 2.23e-48

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 160.68  E-value: 2.23e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSKAGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAVCE 171
Cdd:cd04418    1 ERTLAIIKPDAVHKAEEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAISY 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 982947816 172 WKRLLGPANSGLARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFP 223
Cdd:cd04418   81 WKELLGPTNSLKAKETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 92-222 5.24e-43

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 146.46  E-value: 5.24e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:cd04413    1 ERTLVIIKPDGVQRglIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982947816 170 CEWKRLLGPANSGLArtdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:cd04413   81 KTVRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 92-222 7.33e-43

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 146.20  E-value: 7.33e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAV-SKAGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAVC 170
Cdd:cd04416    1 EYTLALIKPDAVaEKKDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAVE 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 982947816 171 EWKRLLGPANSGLARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:cd04416   81 EWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 90-229 2.61e-42

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 145.21  E-value: 2.61e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  90 KKEKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDD 167
Cdd:COG0105    1 AMERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGEN 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982947816 168 AVCEWKRLLGPANSGLArtdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFPSSGVCG 229
Cdd:COG0105   81 AVAVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFSEEEIVS 139
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 92-225 3.30e-40

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 139.47  E-value: 3.30e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:PRK00668   2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982947816 170 CEWKRLLGPANSGLArtdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFPSS 225
Cdd:PRK00668  82 AKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 92-223 1.54e-38

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 135.22  E-value: 1.54e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVS---KAGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDA 168
Cdd:cd04414    1 QLTLALIKPDAVAhplALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 982947816 169 VCEWKRLLGPANSGLARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFP 223
Cdd:cd04414   81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 89-222 1.10e-35

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 129.17  E-value: 1.10e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  89 SKKEKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRD 166
Cdd:PLN02931  27 SEEERTLAMIKPDGLSGnyTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLEKE 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 982947816 167 DAVCEWKRLLGPANSGLARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:PLN02931 107 NAVSDWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFF 162
NDK pfam00334
Nucleoside diphosphate kinase;
241-367 1.12e-35

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 127.60  E-value: 1.12e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG-KPFFPDLVEFMTSGPVVAMVLEGENAIS 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 982947816  321 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:pfam00334  82 KWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAERE 125
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 3-91 9.08e-31

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 113.56  E-value: 9.08e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816     3 HSERFVFIAEWFDPNA--SLFRRYELLFYPGDGSVEMH--DVKN----HRTFLKRTKY--------EDLHLEDLFIGNKV 66
Cdd:smart00676   1 DKKVLRFDAYWEDPVAmfYLIRRFKIYYYLEDDTIEVFepDVRNsgilQGTFLRRQRVpkpppddpEYYHASDLNVGTTI 80

                           90       100
                   ....*....|....*....|....*
gi 982947816    67 NIFSRQLVLLDYgDQYTARQLGSKK 91
Cdd:smart00676  81 NVFGRQFRIYDC-DEFTRNYLESKG 104
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 94-222 1.36e-30

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 113.88  E-value: 1.36e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  94 TLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQS-RPFLNELIQFITSGPIIAMEILRDDAVC 170
Cdd:cd04412    3 TVCIIKPHAVSHglLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGvVPELPAMVDELTSGPCIALEIAGENAVK 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 982947816 171 EWKRLLGPANSGLARTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:cd04412   83 TFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 92-222 8.97e-28

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 106.68  E-value: 8.97e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:PRK14542   2 SRTFIMIKPDGVKNkhVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982947816 170 CEWKRLLGPANSGLArtdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:PRK14542  82 LHWREVIGATDPKEA---AAGTIRALYAESKEANAVHGSDSDANAALEISFFF 131
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 241-362 2.52e-26

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 102.84  E-value: 2.52e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:COG0105    5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKG-KPFFGELVEFMTSGPVVAMVLEGENAVA 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 982947816 321 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPE 362
Cdd:COG0105   84 VVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPE 122
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 91-222 2.64e-26

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 102.88  E-value: 2.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  91 KEKTLALIKPDAVSK--AGEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDA 168
Cdd:PTZ00093   2 SERTFIMVKPDGVQRglVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982947816 169 VCEWKRLLGPANSGlarTDAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:PTZ00093  82 VKQGRKLLGATNPL---ESAPGTIRGDFCVDVGRNVIHGSDSVESAKREIALWF 132
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 241-367 6.90e-26

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 101.01  E-value: 6.90e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:cd04413    3 TLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKG-KPFFPELVEFMTSGPVVAMVLEGENAVK 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 982947816 321 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:cd04413   82 TVRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSDSVESAERE 125
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 91-222 4.96e-25

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 99.13  E-value: 4.96e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  91 KEKTLALIKPDAVSKA--GEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDA 168
Cdd:PRK14540   2 KERTFVALKPDAVERKliGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENA 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 982947816 169 VCEWKRLLGPANSGLARtdaPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:PRK14540  82 ISTVRKMIGKTNPAEAE---PGTIRGDFGLYTPANIIHASDSKESAEREIKLFF 132
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 241-363 1.69e-24

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 97.67  E-value: 1.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLgKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGVvSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:cd04416    3 TLALIKPDAVAEKKD-EILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEE-DYFEDLVEFMTSGPSLILVLSKENAVE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 982947816 321 TFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPED 363
Cdd:cd04416   81 EWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEE 123
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 93-222 2.52e-23

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 94.59  E-value: 2.52e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  93 KTLALIKPDAVSKA--GEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAVC 170
Cdd:PRK14545   5 RTFTMIKPDAVENGhiGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVE 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 982947816 171 EWKRLLGPANSglarTDAPE-SIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:PRK14545  85 DFRTLIGATNP----ADAAEgTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 92-227 4.13e-23

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 94.24  E-value: 4.13e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSKA--GEIIEIINKAGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMEILRDDAV 169
Cdd:PRK14541   2 ERTLTILKPDCVRKQliGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENAV 81

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 982947816 170 CEWKRLLGPANSGLArtdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFFPSSGV 227
Cdd:PRK14541  82 ADFRTLIGATDPAEA---AEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFFSAEEV 136
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 244-362 1.92e-21

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 89.01  E-value: 1.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 244 IVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTMTFR 323
Cdd:PRK00668   7 IIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKE-KPFFGELVEFMTSGPVVVMVLEGENAIAKVR 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 982947816 324 EFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPE 362
Cdd:PRK00668  86 ELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPE 121
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 241-367 1.12e-18

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 81.64  E-value: 1.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYkGVVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:PRK14542   4 TFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVH-SARPFYNDLCNYMSSGPIVAAALERDNAVL 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 982947816 321 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:PRK14542  83 HWREVIGATDPKEA---AAGTIRALYAESKEANAVHGSDSDANAALE 126
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 241-362 1.77e-18

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 81.02  E-value: 1.77e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:PRK14540   5 TFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKG-KEFYERLINFMTSGRIVAMVIEGENAIS 83

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 982947816 321 TFREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPE 362
Cdd:PRK14540  84 TVRKMIGKTNPAEA---EPGTIRGDFGLYTPANIIHASDSKE 122
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 241-367 2.60e-18

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 80.76  E-value: 2.60e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:PRK14541   4 TLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRE-RPFYGELVEFMSSGPCVPMILEKENAVA 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 982947816 321 TFREFCGPADPEIARHlrpGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:PRK14541  83 DFRTLIGATDPAEAAE---GTVRKLYADSKGENIVHGSDSAENAAIE 126
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 241-367 9.13e-18

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 79.18  E-value: 9.13e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:PRK14545   6 TFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAE-RPFYGELVEFMSRGPIVAAILEKENAVE 84

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 982947816 321 TFREFCGPADPEIARHlrpGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:PRK14545  85 DFRTLIGATNPADAAE---GTIRKKYAKSIGENAVHGSDSDENAQIE 128
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 92-222 7.53e-16

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 75.23  E-value: 7.53e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSKA--GEIIEIINKAGFTLTKLKMMTLSRKEATDFH----------------------IDHQSR---- 143
Cdd:PRK14544   4 ERTLVILKPDAVKRGlvGEIISRFEKAGLKIVAMKMVKATPEQIERFYpsseewyrsvgnkllkayqelgIDPRARlgtd 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 144 -PFL------NELIQFITSGPIIAMEILRDDAVCEWKRLLGPANSGLArtdAPESIRALFGTDG----------IKNAAH 206
Cdd:PRK14544  84 dPVEvgkkvkESLVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYSIDSpdlaaeegrvVYNLVH 160

                        170
                 ....*....|....*.
gi 982947816 207 GPDSFACAAREMELFF 222
Cdd:PRK14544 161 ASDSPEEAEREIKFWF 176
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 241-359 2.05e-15

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 72.47  E-value: 2.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGllGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGVVSeYNEMVTEMYSGPCVAMEIQQTNPTM 320
Cdd:cd04418    3 TLAIIKPDAVHKA--EEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMF-FPHLVAYMSSGPIVAMVLARHNAIS 79

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 982947816 321 TFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTD 359
Cdd:cd04418   80 YWKELLGPTNSLKAKETHPDSLRAIYGTDDLRNAVHGSD 118
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 241-367 1.15e-14

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 70.51  E-value: 1.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGL-LGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGVVSeYNEMVTEMYSGPCVAMEIQQTNPT 319
Cdd:cd04414    3 TLALIKPDAVAHPLaLEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFF-YDRLVSFMTSGPSWALILAHENAI 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 982947816 320 MTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPEDGLLE 367
Cdd:cd04414   82 KTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQRE 129
PLN02619 PLN02619
nucleoside-diphosphate kinase
 92-222 1.94e-13

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 69.49  E-value: 1.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSKaGEIIEIINK---AGFTLTKLKMMTLSRKEATDFHIDHQSRPFLNELIQFITSGPIIAMeILRDDA 168
Cdd:PLN02619  89 ERTFIAIKPDGVQR-GLISEIISRferKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAM-VWEGEG 166

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 982947816 169 VCEWKR-LLG---PANSglartdAPESIRALFGTDGIKNAAHGPDSFACAAREMELFF 222
Cdd:PLN02619 167 VIKYGRkLIGatdPQKS------EPGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWF 218
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 241-363 3.59e-13

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 67.53  E-value: 3.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFY----EVYKGVVSE----YNEM------------- 299
Cdd:PRK14544   6 TLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFYpsseEWYRSVGNKllkaYQELgidprarlgtddp 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 300 -----------VTEMYSGPCVAMEIQQTNPTMTFREFCGPADPEIArhlRPGTLRAIFG----------KTKIQNAVHCT 358
Cdd:PRK14544  86 vevgkkvkeslVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYSidspdlaaeeGRVVYNLVHAS 162


                 ....*
gi 982947816 359 DLPED 363
Cdd:PRK14544 163 DSPEE 167
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 220-362 3.47e-11

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 61.76  E-value: 3.47e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 220 LFFPSSGVCGPANTAKFTNCTTCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGVvSEYNEM 299
Cdd:PLN02931  11 LLLLASFPIRCSSSGASEEERTLAMIKPDGLSGNYTERIKEVILESGFSIVKEMTTQLDEDRASLFYAEHSSR-SFFPSL 89

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 982947816 300 VTEMYSGPCVAMEIQQTNPTMTFREFCGPADPEIARHLRPGTLRAIFGKTKIQNAVHCTDLPE 362
Cdd:PLN02931  90 VKYMTSGPVLVMVLEKENAVSDWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPE 152
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 241-367 7.28e-10

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 57.60  E-value: 7.28e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 241 TCCIVKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYeVYKGVVSEYNEMVTE-----MYSGPCVAMEIQQ 315
Cdd:PRK14543   8 TLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHY-LYDDIAVRHGEAVWKslikfISSSPVFVFVVEG 86

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 982947816 316 TNPTMTFREFCGPADPEIArhlRPGTLRAIFG----------KTKIQNAVHCTDLPEDGLLE 367
Cdd:PRK14543  87 VESVEVVRKFCGSTEPKLA---IPGTIRGDFSyhsfnyanekGFSVYNVIHASANEDDALRE 145
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 245-363 2.32e-09

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 55.50  E-value: 2.32e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 245 VKPHAVSEGLLGKILMTIRDAGFEISAMQMFNMDRINVEEFYEVYKGvVSEYNEMVTEMYSGPCVAMEIQQTNPTMTFRE 324
Cdd:PTZ00093   9 VKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKG-KPFFPGLVKYISSGPVVCMVWEGKNVVKQGRK 87

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 982947816 325 FCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPED 363
Cdd:PTZ00093  88 LLGATNPLES---APGTIRGDFCVDVGRNVIHGSDSVES 123
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 92-222 1.43e-06

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 47.97  E-value: 1.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816  92 EKTLALIKPDAVSKA--GEIIEIINKAGFTLTKLKMMTLSRKEAT------DFHIDHqSRPFLNELIQFITSGPIIAMEI 163
Cdd:PRK14543   6 QKTLCIIKPDGVRRGliGNVVSRFERVGLKIVAAKMLLVDRSMAEkhylydDIAVRH-GEAVWKSLIKFISSSPVFVFVV 84

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982947816 164 LRDDAVCEWKRLLGPANSGLArtdAPESIRALFGTDGIK----------NAAHGPDSFACAAREMELFF 222
Cdd:PRK14543  85 EGVESVEVVRKFCGSTEPKLA---IPGTIRGDFSYHSFNyanekgfsvyNVIHASANEDDALREIPIWF 150
PLN02619 PLN02619
nucleoside-diphosphate kinase
 245-362 3.50e-03

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 38.68  E-value: 3.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982947816 245 VKPHAVSEGLLGKILMTIRDAGFEISAMQMFnmdrINVEEFYEVYKGVVSE---YNEMVTEMYSGPCVAMEIQQTNPTMT 321
Cdd:PLN02619  95 IKPDGVQRGLISEIISRFERKGFKLVAIKVV----VPSKEFAQKHYHDLKErpfFNGLCDFLSSGPVVAMVWEGEGVIKY 170

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 982947816 322 FREFCGPADPEIArhlRPGTLRAIFGKTKIQNAVHCTDLPE 362
Cdd:PLN02619 171 GRKLIGATDPQKS---EPGTIRGDLAVVVGRNIIHGSDGPE 208
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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