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Conserved domains on  [gi|1003728981|ref|XP_015730811|]
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nucleoside diphosphate kinase 7 isoform X4 [Coturnix japonica]

Protein Classification

NME7 family nucleoside-diphosphate kinase( domain architecture ID 11885871)

NME7 family nucleoside-diphosphate kinase similar to nucleoside diphosphate kinase 7, which plays a major role in the synthesis of nucleoside triphosphates other than ATP

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 92-222 9.60e-88

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239878  Cd Length: 131  Bit Score: 260.84  E-value: 9.60e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAICK 171
Cdd:cd04415     1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1003728981 172 WKTLLGPANSAVARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:cd04415    81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 238-371 9.83e-81

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


:

Pssm-ID: 239875  Cd Length: 134  Bit Score: 242.92  E-value: 9.83e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 238 NCTCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGVVAEYMEMVTVLCSGPCIAMEIIQPEP 317
Cdd:cd04412     1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1003728981 318 PNVFRNFCGPSDPEIARHLRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFF 371
Cdd:cd04412    81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
DM10_dom super family cl26962
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 6-91 8.22e-25

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


The actual alignment was detected with superfamily member smart00676:

Pssm-ID: 474875  Cd Length: 104  Bit Score: 97.00  E-value: 8.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981    6 RFAFTAEWYDPNA--SLFRRYELLYYPKDSSVEMY--DVKN----HRTFLKRTKY--------ESLHLDDLFVGNKITVF 69
Cdd:smart00676   4 VLRFDAYWEDPVAmfYLIRRFKIYYYLEDDTIEVFepDVRNsgilQGTFLRRQRVpkpppddpEYYHASDLNVGTTINVF 83

                           90       100
                   ....*....|....*....|..
gi 1003728981   70 SRHLSLVDYgDQYTARKLGGRK 91
Cdd:smart00676  84 GRQFRIYDC-DEFTRNYLESKG 104
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 92-222 9.60e-88

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 260.84  E-value: 9.60e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAICK 171
Cdd:cd04415     1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1003728981 172 WKTLLGPANSAVARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:cd04415    81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 238-371 9.83e-81

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 242.92  E-value: 9.83e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 238 NCTCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGVVAEYMEMVTVLCSGPCIAMEIIQPEP 317
Cdd:cd04412     1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1003728981 318 PNVFRNFCGPSDPEIARHLRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFF 371
Cdd:cd04412    81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 92-225 7.31e-63

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 197.39  E-value: 7.31e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981   92 ERTLALIKPDAT--PKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:smart00562   1 ERTLAIIKPDAVqrGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1003728981  170 CKWKTLLGPANsavARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFPSS 225
Cdd:smart00562  81 KTWRTLMGPTD---PREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPES 133
NDK pfam00334
Nucleoside diphosphate kinase;
92-225 5.59e-59

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 187.31  E-value: 5.59e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1003728981 170 CKWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFPSS 225
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 92-223 1.07e-48

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 161.00  E-value: 1.07e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:COG0105     3 ERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1003728981 170 CKWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFP 223
Cdd:COG0105    83 AVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 92-225 1.21e-46

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 155.65  E-value: 1.21e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:PRK00668    2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1003728981 170 CKWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFPSS 225
Cdd:PRK00668   82 AKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 238-375 2.48e-46

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 154.63  E-value: 2.48e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  238 NCTCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGvVAEYMEMVTVLCSGPCIAMEIIQPEP 317
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEG-KPFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1003728981  318 PNVFRNFCGPSDPeiaRHLRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFKILD 375
Cdd:smart00562  80 VKTWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDK pfam00334
Nucleoside diphosphate kinase;
240-372 5.73e-36

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 127.60  E-value: 5.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGvVAEYMEMVTVLCSGPCIAMEIiqpEPPN 319
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG-KPFFPDLVEFMTSGPVVAMVL---EGEN 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1003728981 320 V---FRNFCGPSDPEIArhlRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:pfam00334  79 AiskWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFP 131
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 240-372 2.20e-28

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 107.85  E-value: 2.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEI------YKGVVaEYMemvtvlCSGPCIAMEIi 313
Cdd:COG0105     5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEhkgkpfFGELV-EFM------TSGPVVAMVL- 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1003728981 314 qpEPPNV---FRNFCGPSDPEIArhlRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:COG0105    77 --EGENAvavVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 6-91 8.22e-25

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 97.00  E-value: 8.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981    6 RFAFTAEWYDPNA--SLFRRYELLYYPKDSSVEMY--DVKN----HRTFLKRTKY--------ESLHLDDLFVGNKITVF 69
Cdd:smart00676   4 VLRFDAYWEDPVAmfYLIRRFKIYYYLEDDTIEVFepDVRNsgilQGTFLRRQRVpkpppddpEYYHASDLNVGTTINVF 83

                           90       100
                   ....*....|....*....|..
gi 1003728981   70 SRHLSLVDYgDQYTARKLGGRK 91
Cdd:smart00676  84 GRQFRIYDC-DEFTRNYLESKG 104
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 243-372 8.97e-23

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 92.48  E-value: 8.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 243 IIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEI------YKGVVaEYMemvtvlCSGPCIAMEIiqpE 316
Cdd:PRK00668    7 IIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEhkekpfFGELV-EFM------TSGPVVVMVL---E 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1003728981 317 PPNV---FRNFCGPSDPEIArhlRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:PRK00668   77 GENAiakVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFS 132
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 9-83 9.08e-07

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 46.69  E-value: 9.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981   9 FTAEWYDPNASLF---RRYELLYYPKDSSVEMYDVKNHR------TFLKRTKY--------ESLHLDDLFVGNKITVFSR 71
Cdd:pfam06565  14 FYAYWDDPTESPEdeyRKFVISYYLADDTIEIFEPPVRNsgrpggKFLKRQRIpkpgtggpEYYTPKDLYVGATVNIYGR 93

                          90
                  ....*....|..
gi 1003728981  72 HLSLVDYgDQYT 83
Cdd:pfam06565  94 RFLLYDC-DEFT 104
 
Name Accession Description Interval E-value
NDPk7A cd04415
Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate ...
 92-222 9.60e-88

Nucleoside diphosphate kinase 7 domain A (NDPk7A): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239878  Cd Length: 131  Bit Score: 260.84  E-value: 9.60e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAICK 171
Cdd:cd04415     1 EKTLALIKPDAYSKIGKIIQIIEDAGFTITKAKMTKLSRKEAQDFYAEHQSKPFYNELVQFMTSGPIVAMELVGDDAISE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1003728981 172 WKTLLGPANSAVARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:cd04415    81 WRKLLGPTNSSVARSDAPNSIRALFGTDGTRNAAHGSDSVASAARELEFFF 131
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 238-371 9.83e-81

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 242.92  E-value: 9.83e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 238 NCTCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGVVAEYMEMVTVLCSGPCIAMEIIQPEP 317
Cdd:cd04412     1 NCTVCIIKPHAVSHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGVVPELPAMVDELTSGPCIALEIAGENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1003728981 318 PNVFRNFCGPSDPEIARHLRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFF 371
Cdd:cd04412    81 VKTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 92-222 7.38e-64

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 199.89  E-value: 7.38e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDAT--PKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:cd00595     1 ERTLALIKPDAVaeGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGRPFFPDLVQFMSSGPVVAMILEKDNAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1003728981 170 CKWKTLLGPANSAVARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:cd00595    81 GEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 92-225 7.31e-63

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 197.39  E-value: 7.31e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981   92 ERTLALIKPDAT--PKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:smart00562   1 ERTLAIIKPDAVqrGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEGKPFFNDLVEFMTSGPVVAMVLEGEDAV 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1003728981  170 CKWKTLLGPANsavARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFPSS 225
Cdd:smart00562  81 KTWRTLMGPTD---PREAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPES 133
NDK pfam00334
Nucleoside diphosphate kinase;
92-225 5.59e-59

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 187.31  E-value: 5.59e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:pfam00334   1 ERTLAIIKPDAVQRglIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKGKPFFPDLVEFMTSGPVVAMVLEGENAI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1003728981 170 CKWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFPSS 225
Cdd:pfam00334  81 SKWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFPEE 133
NDPk cd00595
Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the ...
 238-371 1.17e-52

Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are vital for DNA/RNA synthesis, cell division, macromolecular metabolism and growth. The enzymes generate NTPs or their deoxy derivatives by terminal (gamma) phosphotransfer from an NTP such as ATP or GTP to any nucleoside diphosphate (NDP) or its deoxy derivative. The sequence of NDPk has been highly conserved through evolution. There is a single histidine residue conserved in all known NDK isozymes, which is involved in the catalytic mechanism. The first confirmed metastasis suppressor gene was the NDP kinase protein encoded by the nm23 gene. Unicellular organisms generally possess only one gene encoding NDP kinase, while most multicellular organisms possess not only an ortholog that provides most of the NDP kinase enzymatic activity but also multiple divergent paralogous genes. The human genome codes for at least nine NDP kinases and can be classified into two groups, Groups I and II, according to their genomic architecture and distinct enzymatic activity. Group I isoforms (A-D) are well-conserved, catalytically active, and share 58-88% identity between each other, while Group II are more divergent, with only NDPk6 shown to be active. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. The hexamer can be viewed as trimer of dimers, while tetramers are dimers of dimers, with the dimerization interface conserved.


Pssm-ID: 238335  Cd Length: 133  Bit Score: 171.00  E-value: 1.17e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 238 NCTCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGVvAEYMEMVTVLCSGPCIAMEIIQPEP 317
Cdd:cd00595     1 ERTLALIKPDAVAEGLLGEIIMRIEDAGFEIVAMKELHLTEEQAEEFYVEHKGR-PFFPDLVQFMSSGPVVAMILEKDNA 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1003728981 318 PNVFRNFCGPSDPEIARHLRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFF 371
Cdd:cd00595    80 VGEWREMLGPTNPEIARHLAPGSLRADFGTDVLRNAVHGSDSVESAAREIAFFF 133
NDPk5 cd04418
Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of ...
 92-223 1.05e-48

Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, in association with axoneme microtubules, and may play a role in spermatogenesis by increasing the ability of late-stage spermatids to eliminate reactive oxygen species. It belongs to the nm23 Group II genes and appears to differ from the other human NDPks in that it lacks two important catalytic site residues, and thus does not appear to possess NDP kinase activity. NDPk5 confers protection from cell death by Bax and alters the cellular levels of several antioxidant enzymes, including glutathione peroxidase 5 (Gpx5).


Pssm-ID: 239880  Cd Length: 132  Bit Score: 161.07  E-value: 1.05e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAICK 171
Cdd:cd04418     1 ERTLAIIKPDAVHKAEEIEDIILESGFTIVQKRKLQLSPEQCSDFYAEHYGKMFFPHLVAYMSSGPIVAMVLARHNAISY 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1003728981 172 WKTLLGPANSAVARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFP 223
Cdd:cd04418    81 WKELLGPTNSLKAKETHPDSLRAIYGTDDLRNAVHGSDSFSSAEREIRFMFP 132
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 92-223 1.07e-48

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 161.00  E-value: 1.07e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:COG0105     3 ERTLVIIKPDAVQRglIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEHKGKPFFGELVEFMTSGPVVAMVLEGENAV 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1003728981 170 CKWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFP 223
Cdd:COG0105    83 AVVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 92-225 1.21e-46

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 155.65  E-value: 1.21e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:PRK00668    2 ERTFSIIKPDAVQRglIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEHKEKPFFGELVEFMTSGPVVVMVLEGENAI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1003728981 170 CKWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFPSS 225
Cdd:PRK00668   82 AKVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFSEE 134
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 92-222 1.33e-46

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 155.32  E-value: 1.33e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:cd04413     1 ERTLVIIKPDGVQRglIGEIISRFERKGLKIVALKMLQLTEELAEEHYAEHKGKPFFPELVEFMTSGPVVAMVLEGENAV 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1003728981 170 CKWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:cd04413    81 KTVRKLMGATNPADA---APGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
NDK smart00562
Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to ...
 238-375 2.48e-46

Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates; These enzymes play important roles in bacterial growth, signal transduction and pathogenicity.


Pssm-ID: 197791  Cd Length: 135  Bit Score: 154.63  E-value: 2.48e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  238 NCTCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGvVAEYMEMVTVLCSGPCIAMEIIQPEP 317
Cdd:smart00562   1 ERTLAIIKPDAVQRGLIGEIISRFERKGFKIVAMKMLQLTEEQAEEFYAEHEG-KPFFNDLVEFMTSGPVVAMVLEGEDA 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1003728981  318 PNVFRNFCGPSDPeiaRHLRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFKILD 375
Cdd:smart00562  80 VKTWRTLMGPTDP---REAAPGTIRGDFGLDIGRNAVHGSDSPESAEREIALFFPESE 134
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 92-222 8.08e-46

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 153.52  E-value: 8.08e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDAT-PKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAIC 170
Cdd:cd04416     1 EYTLALIKPDAVaEKKDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEEEDYFEDLVEFMTSGPSLILVLSKENAVE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1003728981 171 KWKTLLGPANSAVARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:cd04416    81 EWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 92-223 5.46e-41

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 141.00  E-value: 5.46e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDA---TPKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDA 168
Cdd:cd04414     1 QLTLALIKPDAvahPLALEAVRQLILSNGFTIVRKKELRWTTEDAERFYAEHKGKFFYDRLVSFMTSGPSWALILAHENA 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1003728981 169 ICKWKTLLGPANSAVARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFFP 223
Cdd:cd04414    81 IKTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFFP 135
PLN02931 PLN02931
nucleoside diphosphate kinase family protein
 90-222 1.01e-39

nucleoside diphosphate kinase family protein


Pssm-ID: 215503  Cd Length: 177  Bit Score: 139.19  E-value: 1.01e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  90 RKERTLALIKPDA-----TPKIGElidIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEIL 164
Cdd:PLN02931   28 EEERTLAMIKPDGlsgnyTERIKE---VILESGFSIVKEMTTQLDEDRASLFYAEHSSRSFFPSLVKYMTSGPVLVMVLE 104

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1003728981 165 RDDAICKWKTLLGPANSAVARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:PLN02931  105 KENAVSDWRTLIGPTDARKAKISHPNSIRAMCGLDSEKNCVHGSDSPESAEREISFFF 162
NDK pfam00334
Nucleoside diphosphate kinase;
240-372 5.73e-36

Nucleoside diphosphate kinase;


Pssm-ID: 459766  Cd Length: 135  Bit Score: 127.60  E-value: 5.73e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGvVAEYMEMVTVLCSGPCIAMEIiqpEPPN 319
Cdd:pfam00334   3 TLAIIKPDAVQRGLIGEIISRFERKGFKIVALKMLQLTREQAEEHYAEHKG-KPFFPDLVEFMTSGPVVAMVL---EGEN 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1003728981 320 V---FRNFCGPSDPEIArhlRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:pfam00334  79 AiskWRELMGATNPAEA---APGTIRGDFAVSIGRNAVHGSDSPESAEREIALFFP 131
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 91-222 3.74e-29

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 109.91  E-value: 3.74e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  91 KERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDA 168
Cdd:PRK14540    2 KERTFVALKPDAVERklIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKGKEFYERLINFMTSGRIVAMVIEGENA 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1003728981 169 ICKWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:PRK14540   82 ISTVRKMIGKTNPAEA---EPGTIRGDFGLYTPANIIHASDSKESAEREIKLFF 132
NDPk7B cd04412
Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate ...
 93-222 4.18e-29

Nucleoside diphosphate kinase 7 domain B (NDPk7B): The nm23-H7 class of nucleoside diphosphate kinase (NDPk7) consists of an N-terminal DM10 domain and two functional catalytic NDPk modules, NDPk7A and NDPk7B. The function of the DM10 domain, which also occurs in multiple copies in other proteins, is unknown. NDPk7 is predominantly expressed in testes, although appreciable amount are also found in liver, heart, brain, ovary, small intestine and spleen. The nm23-H7 gene is located in or near the hereditary prostrate cancer susceptibility locus. Nm23-H7 may be involved in the development of colon and gastric carcinoma, the latter possibly in a type-specific manner.


Pssm-ID: 239875  Cd Length: 134  Bit Score: 109.65  E-value: 4.18e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  93 RTLALIKPDA--TPKIGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQS-RPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:cd04412     2 CTVCIIKPHAvsHGLLGEILQQILDEGFEITALQMFNLTRANAEEFLEVYKGvVPELPAMVDELTSGPCIALEIAGENAV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1003728981 170 CKWKTLLGPANSAVARTDEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:cd04412    82 KTFREFCGPFDPEIAKQLRPNTLRARYGKDKVQNAVHCTDLPEDGPLELKFFF 134
Ndk COG0105
Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate ...
 240-372 2.20e-28

Nucleoside diphosphate kinase [Nucleotide transport and metabolism]; Nucleoside diphosphate kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 439875  Cd Length: 140  Bit Score: 107.85  E-value: 2.20e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEI------YKGVVaEYMemvtvlCSGPCIAMEIi 313
Cdd:COG0105     5 TLVIIKPDAVQRGLIGEIISRFERKGLKIVALKMLQLTREQAEEHYAEhkgkpfFGELV-EFM------TSGPVVAMVL- 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1003728981 314 qpEPPNV---FRNFCGPSDPEIArhlRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:COG0105    77 --EGENAvavVRKLMGATNPAEA---APGTIRGDFALSIGENAVHGSDSPESAEREIALFFS 133
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 92-222 2.45e-28

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 107.83  E-value: 2.45e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:PRK14542    2 SRTFIMIKPDGVKNkhVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVHSARPFYNDLCNYMSSGPIVAAALERDNAV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1003728981 170 CKWKTLLGPANSAVARTDepeSIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:PRK14542   82 LHWREVIGATDPKEAAAG---TIRALYAESKEANAVHGSDSDANAALEISFFF 131
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 91-222 3.37e-28

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 107.89  E-value: 3.37e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  91 KERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDA 168
Cdd:PTZ00093    2 SERTFIMVKPDGVQRglVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKGKPFFPGLVKYISSGPVVCMVWEGKNV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1003728981 169 ICKWKTLLG---PANSAvartdePESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:PTZ00093   82 VKQGRKLLGatnPLESA------PGTIRGDFCVDVGRNVIHGSDSVESAKREIALWF 132
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 92-222 4.28e-27

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 104.64  E-value: 4.28e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAI 169
Cdd:PRK14541    2 ERTLTILKPDCVRKqlIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRERPFYGELVEFMSSGPCVPMILEKENAV 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1003728981 170 CKWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:PRK14541   82 ADFRTLIGATDPAEA---AEGTVRKLYADSKGENIVHGSDSAENAAIEAGFFF 131
NDPk_I cd04413
Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large ...
 240-371 4.86e-27

Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside triphosphate (NTP) donor onto a nucleoside diphosphate (NDP) acceptor through a phosphohistidine intermediate. The mammalian nm23/NDP kinase gene family can be divided into two distinct groups. The group I genes encode proteins that generally have highly homologous counterparts in other organisms and possess the classic enzymatic activity of a kinase. This group includes vertebrate NDP kinases A-D (Nm23- H1 to -H4), and its counterparts in bacteria, archea and other eukaryotes. NDP kinases exist in two different quaternary structures; all known eukaryotic enzymes are hexamers, while some bacterial enzymes are tetramers, as in Myxococcus. They possess the NDP kinase active site motif (NXXH[G/A]SD) and the nine residues that are most essential for catalysis.


Pssm-ID: 239876  Cd Length: 130  Bit Score: 104.09  E-value: 4.86e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYE------IYKGVVaEYMemvtvlCSGPCIAMEIi 313
Cdd:cd04413     3 TLVIIKPDGVQRGLIGEIISRFERKGLKIVALKMLQLTEELAEEHYAehkgkpFFPELV-EFM------TSGPVVAMVL- 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1003728981 314 qpEPPNV---FRNFCGPSDPEIARhlrPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFF 371
Cdd:cd04413    75 --EGENAvktVRKLMGATNPADAA---PGTIRGDFALSIGRNIVHGSDSVESAEREIALWF 130
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 93-222 4.78e-25

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 98.82  E-value: 4.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  93 RTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMEILRDDAIC 170
Cdd:PRK14545    5 RTFTMIKPDAVENghIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAERPFYGELVEFMSRGPIVAAILEKENAVE 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1003728981 171 KWKTLLGPANSAVArtdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:PRK14545   85 DFRTLIGATNPADA---AEGTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
DM10 smart00676
Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some ...
 6-91 8.22e-25

Domains in hypothetical proteins in Drosophila, C. elegans and mammals. Occurs singly in some nucleoside diphosphate kinases;


Pssm-ID: 128921  Cd Length: 104  Bit Score: 97.00  E-value: 8.22e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981    6 RFAFTAEWYDPNA--SLFRRYELLYYPKDSSVEMY--DVKN----HRTFLKRTKY--------ESLHLDDLFVGNKITVF 69
Cdd:smart00676   4 VLRFDAYWEDPVAmfYLIRRFKIYYYLEDDTIEVFepDVRNsgilQGTFLRRQRVpkpppddpEYYHASDLNVGTTINVF 83

                           90       100
                   ....*....|....*....|..
gi 1003728981   70 SRHLSLVDYgDQYTARKLGGRK 91
Cdd:smart00676  84 GRQFRIYDC-DEFTRNYLESKG 104
ndk PRK00668
mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
 243-372 8.97e-23

mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated


Pssm-ID: 179085  Cd Length: 134  Bit Score: 92.48  E-value: 8.97e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 243 IIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEI------YKGVVaEYMemvtvlCSGPCIAMEIiqpE 316
Cdd:PRK00668    7 IIKPDAVQRGLIGEIISRFEKKGLKIVALKMMQLSRELAEGHYAEhkekpfFGELV-EFM------TSGPVVVMVL---E 76

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1003728981 317 PPNV---FRNFCGPSDPEIArhlRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:PRK00668   77 GENAiakVRELMGATNPAEA---APGTIRGDFALSIGENVVHGSDSPESAAREIALFFS 132
NDPk_TX cd04416
NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 ...
 239-371 1.48e-21

NDP kinase domain of thioredoxin domain-containing proteins (TXNDC3 and TXNDC6): Txl-2 (TXNDC6) and Sptrx-2 (TXNDC3) are fusion proteins of Group II N-terminal thioredoxin domains followed by one or three NDP kinase domains, respectively. Sptrx-2, which has a tissue specific distribution in human testis, has been considered as a member of the nm23 family (nm23-H8) and exhibits a high homology with sea urchin IC1 (intermediate chain-1) protein, a component of the sperm axonemal outer dynein arm complex. Txl-2 is mainly represented in close association with microtubules within tissues with cilia and flagella such as seminiferous epithelium (spermatids) and lung airway epithelium, suggesting possible role in control of microtubule stability and maintenance.


Pssm-ID: 239879  Cd Length: 132  Bit Score: 89.19  E-value: 1.48e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 239 CTCCIIKPHAVNEGlAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGvvAEYME-MVTVLCSGPCIAMEIIQPEP 317
Cdd:cd04416     2 YTLALIKPDAVAEK-KDEILEKIKEAGFEILAQKEMVLTEEQAREFYKEHEE--EDYFEdLVEFMTSGPSLILVLSKENA 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1003728981 318 PNVFRNFCGPSDPEIARHLRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFF 371
Cdd:cd04416    79 VEEWRELMGPTDPEEAKEEKPDSLRAQFARDHLSNAVHGSSSAEEAEKEIDFFF 132
PRK14540 PRK14540
nucleoside diphosphate kinase; Provisional
 240-372 8.70e-20

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184733  Cd Length: 134  Bit Score: 84.49  E-value: 8.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGvvAEYME-MVTVLCSGPCIAMEIIQPEPP 318
Cdd:PRK14540    5 TFVALKPDAVERKLIGKIIQRFENKGFEIVEMKMLKLTREMAEEYYEEHKG--KEFYErLINFMTSGRIVAMVIEGENAI 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1003728981 319 NVFRNFCGPSDPEIArhlRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:PRK14540   83 STVRKMIGKTNPAEA---EPGTIRGDFGLYTPANIIHASDSKESAEREIKLFFG 133
PRK14542 PRK14542
nucleoside diphosphate kinase; Provisional
 240-372 5.42e-18

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173008 [Multi-domain]  Cd Length: 137  Bit Score: 79.71  E-value: 5.42e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYkGVVAEYMEMVTVLCSGPCIAMEIIQPEPPN 319
Cdd:PRK14542    4 TFIMIKPDGVKNKHVGNILQRIEKEGFKILGLKYLKLSLEDAKQFYKVH-SARPFYNDLCNYMSSGPIVAAALERDNAVL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1003728981 320 VFRNFCGPSDPEIARhlrPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:PRK14542   83 HWREVIGATDPKEAA---AGTIRALYAESKEANAVHGSDSDANAALEISFFFK 132
PRK14545 PRK14545
nucleoside diphosphate kinase; Provisional
 237-371 5.50e-18

nucleoside diphosphate kinase; Provisional


Pssm-ID: 184734  Cd Length: 139  Bit Score: 79.56  E-value: 5.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 237 TNCTCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGvVAEYMEMVTVLCSGPCIAMEIIQPE 316
Cdd:PRK14545    3 GNRTFTMIKPDAVENGHIGGILDMITAAGFRIVAMKLTQLTVADAETFYAVHAE-RPFYGELVEFMSRGPIVAAILEKEN 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1003728981 317 PPNVFRNFCGPSDPEIARHlrpGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFF 371
Cdd:PRK14545   82 AVEDFRTLIGATNPADAAE---GTIRKKYAKSIGENAVHGSDSDENAQIEGAFHF 133
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 92-222 2.29e-17

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 79.09  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQS--RPFYNELL----------------- 150
Cdd:PRK14544    4 ERTLVILKPDAVKRglVGEIISRFEKAGLKIVAMKMVKATPEQIERFYPSSEEwyRSVGNKLLkayqelgidprarlgtd 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 151 --------------QFITSGPVVAMEILRDDAICKWKTLLGPANSAVArtdEPESIRANFGHDG----------LKNAAH 206
Cdd:PRK14544   84 dpvevgkkvkeslvKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYSIDSpdlaaeegrvVYNLVH 160

                         170
                  ....*....|....*.
gi 1003728981 207 GPDSVASAARELEFFF 222
Cdd:PRK14544  161 ASDSPEEAEREIKFWF 176
NDPk6 cd04414
Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced ...
 240-371 4.20e-17

Nucleoside diphosphate kinase 6 (NDP kinase 6, NDPk6, NM23-H6; NME6; Inhibitor of p53-induced apoptosis-alpha, IPIA-alpha): The nm23-H6 gene encoding NDPk6 is expressed mainly in mitochondria, but also found at a lower level in most tissues. NDPk6 has all nine residues considered crucial for enzyme structure and activity, and has been found to have NDP kinase activity. It may play a role in cell growth and cell cycle progression. The nm23-H6 gene locus has been implicated in a variety of malignant tumors.


Pssm-ID: 239877  Cd Length: 135  Bit Score: 77.05  E-value: 4.20e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKA-IVNEGFQISALQMFNMERANAEEFYEIYKGVVAeYMEMVTVLCSGPCIAMEIIQPEPP 318
Cdd:cd04414     3 TLALIKPDAVAHPLALEAVRQlILSNGFTIVRKKELRWTTEDAERFYAEHKGKFF-YDRLVSFMTSGPSWALILAHENAI 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1003728981 319 NVFRNFCGPSDPEIARHLRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFF 371
Cdd:cd04414    82 KTWRALMGPTKVFRARASAPDSIRGLYGLTDTRNATHGSDSPASAQREIALFF 134
PRK14541 PRK14541
nucleoside diphosphate kinase; Provisional
 240-371 2.36e-16

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173007  Cd Length: 140  Bit Score: 74.98  E-value: 2.36e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGvVAEYMEMVTVLCSGPCIAMEIIQPEPPN 319
Cdd:PRK14541    4 TLTILKPDCVRKQLIGAVIDKIERAGFRVVAMKKTRLTKETAGEFYAVHRE-RPFYGELVEFMSSGPCVPMILEKENAVA 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1003728981 320 VFRNFCGPSDPEIARHlrpGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFF 371
Cdd:PRK14541   83 DFRTLIGATDPAEAAE---GTVRKLYADSKGENIVHGSDSAENAAIEAGFFF 131
PLN02619 PLN02619
nucleoside-diphosphate kinase
 92-222 5.31e-14

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 71.03  E-value: 5.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFYVDHQSRPFYNELLQFITSGPVVAMeILRDDAI 169
Cdd:PLN02619   89 ERTFIAIKPDGVQRglISEIISRFERKGFKLVAIKVVVPSKEFAQKHYHDLKERPFFNGLCDFLSSGPVVAM-VWEGEGV 167

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1003728981 170 CKW-KTLLG---PANSavartdEPESIRANFGHDGLKNAAHGPDSVASAARELEFFF 222
Cdd:PLN02619  168 IKYgRKLIGatdPQKS------EPGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWF 218
PRK14544 PRK14544
nucleoside diphosphate kinase; Provisional
 240-372 1.66e-13

nucleoside diphosphate kinase; Provisional


Pssm-ID: 173010 [Multi-domain]  Cd Length: 183  Bit Score: 68.30  E-value: 1.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFY----EIYKGV----VAEYMEM------------- 298
Cdd:PRK14544    6 TLVILKPDAVKRGLVGEIISRFEKAGLKIVAMKMVKATPEQIERFYpsseEWYRSVgnklLKAYQELgidprarlgtddp 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 299 -----------VTVLCSGPCIAMEIIQPEPPNVFRNFCGPSDPEIArhlRPGTLRAVFG----------KNKIRNAVHCT 357
Cdd:PRK14544   86 vevgkkvkeslVKYMTSGPIVAMVLKGNRAVEVVRKLVGPTSPHKA---PPGTIRGDYSidspdlaaeeGRVVYNLVHAS 162

                         170
                  ....*....|....*
gi 1003728981 358 DLPEDGLLEVQYFFK 372
Cdd:PRK14544  163 DSPEEAEREIKFWFR 177
PTZ00093 PTZ00093
nucleoside diphosphate kinase, cytosolic; Provisional
 244-372 8.03e-13

nucleoside diphosphate kinase, cytosolic; Provisional


Pssm-ID: 173387  Cd Length: 149  Bit Score: 65.51  E-value: 8.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 244 IKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKGvVAEYMEMVTVLCSGPCIAMEIIQPEPPNVFRN 323
Cdd:PTZ00093    9 VKPDGVQRGLVGEIIKRFEKKGYKLVALKMLQPTPEIAEEHYKEHKG-KPFFPGLVKYISSGPVVCMVWEGKNVVKQGRK 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1003728981 324 FCGPSDPEIArhlRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:PTZ00093   88 LLGATNPLES---APGTIRGDFCVDVGRNVIHGSDSVESAKREIALWFK 133
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 240-372 9.03e-13

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 65.69  E-value: 9.03e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 240 TCCIIKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYeIYKGVVAEYME-----MVTVLCSGPCIAMEIIQ 314
Cdd:PRK14543    8 TLCIIKPDGVRRGLIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHY-LYDDIAVRHGEavwksLIKFISSSPVFVFVVEG 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1003728981 315 PEPPNVFRNFCGPSDPEIArhlRPGTLRAVFG----------KNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:PRK14543   87 VESVEVVRKFCGSTEPKLA---IPGTIRGDFSyhsfnyanekGFSVYNVIHASANEDDALREIPIWFK 151
PRK14543 PRK14543
nucleoside diphosphate kinase; Provisional
 92-222 3.04e-08

nucleoside diphosphate kinase; Provisional


Pssm-ID: 237749  Cd Length: 169  Bit Score: 52.59  E-value: 3.04e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981  92 ERTLALIKPDATPK--IGELIDIIINAGFTITKAKMMMLSRKEAADFY-----VDHQSRPFYNELLQFITSGPVVAMEIL 164
Cdd:PRK14543    6 QKTLCIIKPDGVRRglIGNVVSRFERVGLKIVAAKMLLVDRSMAEKHYlyddiAVRHGEAVWKSLIKFISSSPVFVFVVE 85

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1003728981 165 RDDAICKWKTLLGPANSAVArtdEPESIRANFGHDGLK----------NAAHGPDSVASAARELEFFF 222
Cdd:PRK14543   86 GVESVEVVRKFCGSTEPKLA---IPGTIRGDFSYHSFNyanekgfsvyNVIHASANEDDALREIPIWF 150
DM10_dom pfam06565
DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 ...
 9-83 9.08e-07

DM10 domain; This entry represents the DM10 domain, which consists of approximately 105 residues whose function is unknown. It has been identified in nucleoside diphosphate kinases, namely Nucleoside diphosphate kinase 7 (NDK7), which contain a single copy of the DM10 domain, and in uncharacterized proteins including Rib72 from Chlamydomonas and EF-hand domain-containing protein 1/EF-hand domain-containing family member C2 (EFHC1/2) from mammals, which contain multiple copies of DM10 domains. In Chlamydomonas, and possibly mammals, DM10 domain-containing proteins are tightly bound to the flagellar doublet microtubules. This suggests that DM10 domains might act as flagellar NDK regulatory modules or as units specifically involved in axonemal targeting or assembly. This domain have a PH-like fold which includes seven beta strands, with a short 3-4 residue helix after the first strand, and a more extended alpha helical region at the C terminus.


Pssm-ID: 461948  Cd Length: 104  Bit Score: 46.69  E-value: 9.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981   9 FTAEWYDPNASLF---RRYELLYYPKDSSVEMYDVKNHR------TFLKRTKY--------ESLHLDDLFVGNKITVFSR 71
Cdd:pfam06565  14 FYAYWDDPTESPEdeyRKFVISYYLADDTIEIFEPPVRNsgrpggKFLKRQRIpkpgtggpEYYTPKDLYVGATVNIYGR 93

                          90
                  ....*....|..
gi 1003728981  72 HLSLVDYgDQYT 83
Cdd:pfam06565  94 RFLLYDC-DEFT 104
PLN02619 PLN02619
nucleoside-diphosphate kinase
 244-372 3.76e-05

nucleoside-diphosphate kinase


Pssm-ID: 178228  Cd Length: 238  Bit Score: 44.45  E-value: 3.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1003728981 244 IKPHAVNEGLAGKIIKAIVNEGFQISALQMFNMERANAEEFYEIYKgvvaE---YMEMVTVLCSGPCIAMEIiqpEPPNV 320
Cdd:PLN02619   95 IKPDGVQRGLISEIISRFERKGFKLVAIKVVVPSKEFAQKHYHDLK----ErpfFNGLCDFLSSGPVVAMVW---EGEGV 167

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1003728981 321 F---RNFCGPSDPEIArhlRPGTLRAVFGKNKIRNAVHCTDLPEDGLLEVQYFFK 372
Cdd:PLN02619  168 IkygRKLIGATDPQKS---EPGTIRGDLAVVVGRNIIHGSDGPETAKDEINLWFK 219
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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