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Conserved domains on  [gi|1034632745|ref|XP_016861714|]
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zinc finger protein 619 isoform X4 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-318 1.76e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.76e-05
                          10        20
                  ....*....|....*....|....*
gi 1034632745 294 LIRHQRIHTGEKPFKCKECGKAFSC 318
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-365 7.38e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 7.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 207 HSDFHLHQRVHTN-EKPYTCKECGKTFRYNSKLSRHQ--KIHTGE--KPYSCEE--CGQAFSQNSHLLQHQKLHGGQRPY 279
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 280 ECTDCGKTFSYNSKLI--RHQRIHtgekPFKCKECGKAFSCSYDCII-----------HERIHNGEKPYECK--ECGKSL 344
Cdd:COG5048   353 KEKLLNSSSKFSPLLNnePPQSLQ----QYKDLKNDKKSETLSNSCIrnfkrdsnlslHIITHLSFRPYNCKnpPCSKSF 428

                         170       180
                  ....*....|....*....|.
gi 1034632745 345 SSNSVLIQHQRIHTGEKPYEC 365
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-456 2.08e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.08e-04
                          10        20
                  ....*....|....*....|...
gi 1034632745 434 LVQHQRVHTGEKPYECKECGKAF 456
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-430 1.97e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|..
gi 1034632745 409 HQRIHNGEKPYECQECGKTFSQ 430
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-318 1.76e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.76e-05
                          10        20
                  ....*....|....*....|....*
gi 1034632745 294 LIRHQRIHTGEKPFKCKECGKAFSC 318
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-365 7.38e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 7.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 207 HSDFHLHQRVHTN-EKPYTCKECGKTFRYNSKLSRHQ--KIHTGE--KPYSCEE--CGQAFSQNSHLLQHQKLHGGQRPY 279
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 280 ECTDCGKTFSYNSKLI--RHQRIHtgekPFKCKECGKAFSCSYDCII-----------HERIHNGEKPYECK--ECGKSL 344
Cdd:COG5048   353 KEKLLNSSSKFSPLLNnePPQSLQ----QYKDLKNDKKSETLSNSCIrnfkrdsnlslHIITHLSFRPYNCKnpPCSKSF 428

                         170       180
                  ....*....|....*....|.
gi 1034632745 345 SSNSVLIQHQRIHTGEKPYEC 365
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-372 1.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|...
gi 1034632745 350 LIQHQRIHTGEKPYECKECGKAF 372
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-456 2.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.08e-04
                          10        20
                  ....*....|....*....|...
gi 1034632745 434 LVQHQRVHTGEKPYECKECGKAF 456
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-430 1.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|..
gi 1034632745 409 HQRIHNGEKPYECQECGKTFSQ 430
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-318 1.76e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 1.76e-05
                          10        20
                  ....*....|....*....|....*
gi 1034632745 294 LIRHQRIHTGEKPFKCKECGKAFSC 318
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
207-365 7.38e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 7.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 207 HSDFHLHQRVHTN-EKPYTCKECGKTFRYNSKLSRHQ--KIHTGE--KPYSCEE--CGQAFSQNSHLLQHQKLHGGQRPY 279
Cdd:COG5048   273 SSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 280 ECTDCGKTFSYNSKLI--RHQRIHtgekPFKCKECGKAFSCSYDCII-----------HERIHNGEKPYECK--ECGKSL 344
Cdd:COG5048   353 KEKLLNSSSKFSPLLNnePPQSLQ----QYKDLKNDKKSETLSNSCIrnfkrdsnlslHIITHLSFRPYNCKnpPCSKSF 428

                         170       180
                  ....*....|....*....|.
gi 1034632745 345 SSNSVLIQHQRIHTGEKPYEC 365
Cdd:COG5048   429 NRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
350-372 1.34e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.34e-04
                          10        20
                  ....*....|....*....|...
gi 1034632745 350 LIQHQRIHTGEKPYECKECGKAF 372
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-456 2.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.08e-04
                          10        20
                  ....*....|....*....|...
gi 1034632745 434 LVQHQRVHTGEKPYECKECGKAF 456
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-262 3.12e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.12e-04
                          10        20
                  ....*....|....*....|....*
gi 1034632745 238 LSRHQKIHTGEKPYSCEECGQAFSQ 262
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 279-301 6.36e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 37.28  E-value: 6.36e-04
                          10        20
                  ....*....|....*....|...
gi 1034632745 279 YECTDCGKTFSYNSKLIRHQRIH 301
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
211-476 9.69e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 9.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 211 HLHQRVHTNEKPYTC--KECGKTFRYNSKLSRHQKIHTGEKPYSCE-ECGQAFSQNSH--------------LLQHQKLH 273
Cdd:COG5048    50 TRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSsslsssssnsndnnLLSSHSLP 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 274 GGQRPYE-CTDCGKTFSYNSKLIRHQRIHTGEK-------PFKCKECGKAFSCSYDCIIHERIHNGEKPYECKECGKSLS 345
Cdd:COG5048   130 PSSRDPQlPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSY 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 346 SNSVLIQHQRIHTGEKPYECKECGKAFHRSSVFLQHQRFHTGEQLYKCNECWKTFSCSSRFIVHQRIHNGE-------KP 418
Cdd:COG5048   210 SIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLP 289

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034632745 419 YECQECGKTFSQKITLVQHQR--VHTGE--KPYECKE--CGKAFRWNASFIQHQKWHTRKKLIN 476
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAK 353
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
181-430 1.63e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.63e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 181 HLITKQGFAKEQVFYKCGECGSYYNPHSDFHLHQRVHTNEKPYTCKECGKTFRYNSKLSRHQKIHTGE-------KPYSC 253
Cdd:COG5048   213 SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKS 292

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 254 EECGQAFSQNSHLLQHQ--KLHGGQ--RPYECT--DCGKTFSYNSKLIRHQRIHTGEKPFKCKEcgkafscsydcIIHER 327
Cdd:COG5048   293 KQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKL-----------LNSSS 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 328 IHNGEKPYEckecgkslssNSVLIQHQRIHTGEKPYEC--KECGKAFHRSSVFLQHQRFHTGEQ--LYKCNECWKTFSCS 403
Cdd:COG5048   362 KFSPLLNNE----------PPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRpyNCKNPPCSKSFNRH 431

                         250       260
                  ....*....|....*....|....*..
gi 1034632745 404 SRFIVHQRIHNGEKPYECQECGKTFSQ 430
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 223-245 1.82e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.82e-03
                          10        20
                  ....*....|....*....|...
gi 1034632745 223 YTCKECGKTFRYNSKLSRHQKIH 245
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
409-430 1.97e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.97e-03
                          10        20
                  ....*....|....*....|..
gi 1034632745 409 HQRIHNGEKPYECQECGKTFSQ 430
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
213-234 3.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.52e-03
                          10        20
                  ....*....|....*....|..
gi 1034632745 213 HQRVHTNEKPYTCKECGKTFRY 234
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 239-316 3.58e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034632745 239 SRHQKIhTGEKPYSCE--ECGQAFsQNSHLLQHQKLHGGQRPyectdcgkTFSYNSKLIRHQRIHTGEKPFKCKECGKAF 316
Cdd:COG5189   339 SRMLKV-KDGKPYKCPveGCNKKY-KNQNGLKYHMLHGHQNQ--------KLHENPSPEKMNIFSAKDKPYRCEVCDKRY 408
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
249-307 3.65e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 3.65e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034632745 249 KPYSCEECGQAFSQNSHLLQHQKLHGGQRPYECTD--CGKTFSYNSKLIRHQRIHTGEKPF 307
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD 92
zf-H2C2_2 pfam13465
Zinc-finger double domain;
265-290 5.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 1034632745 265 HLLQHQKLHGGQRPYECTDCGKTFSY 290
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 419-441 8.00e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 8.00e-03
                          10        20
                  ....*....|....*....|...
gi 1034632745 419 YECQECGKTFSQKITLVQHQRVH 441
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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