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Conserved domains on  [gi|1034633158|ref|XP_016861850|]
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protein TOPAZ1 isoform X2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Asp_Glu_race_2 super family cl20623
Putative aspartate racemase; This is a small family of vertebrate putative aspartate racemases. ...
 1287-1435 1.42e-84

Putative aspartate racemase; This is a small family of vertebrate putative aspartate racemases. The family lies on TOPAZ 1 proteins.


The actual alignment was detected with superfamily member pfam14669:

Pssm-ID: 464250  Cd Length: 176  Bit Score: 273.91  E-value: 1.42e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633158 1287 LEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFCACIAETLTKNYEDERPDIPFCEFAETVSKDPQNSKVDKGVLGRIGI 1366
Cdd:pfam14669    1 IQHCKEKEDWAKLGTLYVNVRSGCEHFNDLQKLSLCIAEILTKDSKEDKPGVPFCEFADAVIKNPQHNEADKTFLGRIGI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034633158 1367 SAMYFYHKLLQWSKGRKVLEKLYELKIHFTSLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGAIWVMR 1435
Cdd:pfam14669   81 SVMYSYHKVLQWSKGRKVLDKLHELQIHFTVLKGLTGNERLASRCQIVNVAAEIFLKSGSLDGATWVLR 149
DUF3827 super family cl28786
Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has ...
 53-151 7.06e-04

Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34. Although nothing is known about the function of Swiss:Q9HCM3 protein, the BRAF protein is a well characterized oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion.


The actual alignment was detected with superfamily member pfam12877:

Pssm-ID: 463737  Cd Length: 677  Bit Score: 44.39  E-value: 7.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633158   53 VARATPGR-GEVESDKSVAASGAGKAARrqvegRRGPVSPSDS----SDPRG-LEAAKEAELPLQTERHTKEKRKVTEA- 125
Cdd:pfam12877  345 VKDATPSEnGEVPTPKSKTSSKTSRGER-----RRGRISPSDGdsvgSDESSkRESGEESPRPAATPSDGKQHRKTNRPg 419

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1034633158  126 ----SSDDPQPG---LDLVRKESLTSSESFQTV 151
Cdd:pfam12877  420 npmnGVSEQLSSasiFEHVDRMSRGSADAFRRS 452
 
Name Accession Description Interval E-value
Asp_Glu_race_2 pfam14669
Putative aspartate racemase; This is a small family of vertebrate putative aspartate racemases. ...
 1287-1435 1.42e-84

Putative aspartate racemase; This is a small family of vertebrate putative aspartate racemases. The family lies on TOPAZ 1 proteins.


Pssm-ID: 464250  Cd Length: 176  Bit Score: 273.91  E-value: 1.42e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633158 1287 LEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFCACIAETLTKNYEDERPDIPFCEFAETVSKDPQNSKVDKGVLGRIGI 1366
Cdd:pfam14669    1 IQHCKEKEDWAKLGTLYVNVRSGCEHFNDLQKLSLCIAEILTKDSKEDKPGVPFCEFADAVIKNPQHNEADKTFLGRIGI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034633158 1367 SAMYFYHKLLQWSKGRKVLEKLYELKIHFTSLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGAIWVMR 1435
Cdd:pfam14669   81 SVMYSYHKVLQWSKGRKVLDKLHELQIHFTVLKGLTGNERLASRCQIVNVAAEIFLKSGSLDGATWVLR 149
DUF3827 pfam12877
Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has ...
 53-151 7.06e-04

Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34. Although nothing is known about the function of Swiss:Q9HCM3 protein, the BRAF protein is a well characterized oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion.


Pssm-ID: 463737  Cd Length: 677  Bit Score: 44.39  E-value: 7.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633158   53 VARATPGR-GEVESDKSVAASGAGKAARrqvegRRGPVSPSDS----SDPRG-LEAAKEAELPLQTERHTKEKRKVTEA- 125
Cdd:pfam12877  345 VKDATPSEnGEVPTPKSKTSSKTSRGER-----RRGRISPSDGdsvgSDESSkRESGEESPRPAATPSDGKQHRKTNRPg 419

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1034633158  126 ----SSDDPQPG---LDLVRKESLTSSESFQTV 151
Cdd:pfam12877  420 npmnGVSEQLSSasiFEHVDRMSRGSADAFRRS 452
 
Name Accession Description Interval E-value
Asp_Glu_race_2 pfam14669
Putative aspartate racemase; This is a small family of vertebrate putative aspartate racemases. ...
 1287-1435 1.42e-84

Putative aspartate racemase; This is a small family of vertebrate putative aspartate racemases. The family lies on TOPAZ 1 proteins.


Pssm-ID: 464250  Cd Length: 176  Bit Score: 273.91  E-value: 1.42e-84
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633158 1287 LEHCKEKGDWTKLGKLYINVKMGCEKFADFQTFCACIAETLTKNYEDERPDIPFCEFAETVSKDPQNSKVDKGVLGRIGI 1366
Cdd:pfam14669    1 IQHCKEKEDWAKLGTLYVNVRSGCEHFNDLQKLSLCIAEILTKDSKEDKPGVPFCEFADAVIKNPQHNEADKTFLGRIGI 80

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034633158 1367 SAMYFYHKLLQWSKGRKVLEKLYELKIHFTSLKGLIGPEKLASRCQIVNVAAEIFLKSGSLDGAIWVMR 1435
Cdd:pfam14669   81 SVMYSYHKVLQWSKGRKVLDKLHELQIHFTVLKGLTGNERLASRCQIVNVAAEIFLKSGSLDGATWVLR 149
DUF3827 pfam12877
Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has ...
 53-151 7.06e-04

Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34. Although nothing is known about the function of Swiss:Q9HCM3 protein, the BRAF protein is a well characterized oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion.


Pssm-ID: 463737  Cd Length: 677  Bit Score: 44.39  E-value: 7.06e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034633158   53 VARATPGR-GEVESDKSVAASGAGKAARrqvegRRGPVSPSDS----SDPRG-LEAAKEAELPLQTERHTKEKRKVTEA- 125
Cdd:pfam12877  345 VKDATPSEnGEVPTPKSKTSSKTSRGER-----RRGRISPSDGdsvgSDESSkRESGEESPRPAATPSDGKQHRKTNRPg 419

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1034633158  126 ----SSDDPQPG---LDLVRKESLTSSESFQTV 151
Cdd:pfam12877  420 npmnGVSEQLSSasiFEHVDRMSRGSADAFRRS 452
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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