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Conserved domains on  [gi|1034643719|ref|XP_016864572|]
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proton-coupled amino acid transporter 2 isoform X2 [Homo sapiens]

Protein Classification

SLC5/6 family protein( domain architecture ID 124)

SLC5/6 (solute carrier 5/6) family protein may function as a transporter

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SLC5-6-like_sbd super family cl00456
Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the ...
 52-281 1.25e-30

Solute carrier families 5 and 6-like; solute binding domain; This superfamily includes the solute-binding domain of SLC5 proteins (also called the sodium/glucose cotransporters or solute sodium symporters), SLC6 proteins (also called the sodium- and chloride-dependent neurotransmitter transporters or Na+/Cl--dependent transporters), and nucleobase-cation-symport-1 (NCS1) transporters. SLC5s co-transport Na+ with sugars, amino acids, inorganic ions or vitamins. SLC6s include Na+/Cl--dependent plasma membrane transporters for the monoamine neurotransmitters serotonin, dopamine, and norepinephrine, and the amino acid neurotransmitters GABA and glycine. NCS1s are essential components of salvage pathways for nucleobases and related metabolites; their known substrates include allantoin, uracil, thiamine, and nicotinamide riboside. Members of this superfamily are important in human physiology and disease. They contain a functional core of 10 transmembrane helices (TMs): an inverted structural repeat, TMs1-5 and TMs6-10; TMs numbered to conform to the SLC6 Aquifex aeolicus LeuT.


The actual alignment was detected with superfamily member pfam01490:

Pssm-ID: 444915  Cd Length: 410  Bit Score: 118.95  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643719  52 KGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAqRFCKRLNKPFMDYGDTVMHgl 131
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCS-KEVPVTGKRNKSYGDLGYR-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643719 132 eanpnawlqNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSttnncysnetvilTPTMDSRLYMLSFLPF 211
Cdd:pfam01490  78 ---------LLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD-------------TCPISLVYFIIIFGLI 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034643719 212 LVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRL-PLVASW-----KTYPLFFGTAIFSFESIGV 281
Cdd:pfam01490 136 FIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVLTAQGvGHLGSKtniklAGTFLAIGIIVFAFEGHAV 211
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
 52-281 1.25e-30

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 118.95  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643719  52 KGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAqRFCKRLNKPFMDYGDTVMHgl 131
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCS-KEVPVTGKRNKSYGDLGYR-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643719 132 eanpnawlqNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSttnncysnetvilTPTMDSRLYMLSFLPF 211
Cdd:pfam01490  78 ---------LLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD-------------TCPISLVYFIIIFGLI 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034643719 212 LVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRL-PLVASW-----KTYPLFFGTAIFSFESIGV 281
Cdd:pfam01490 136 FIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVLTAQGvGHLGSKtniklAGTFLAIGIIVFAFEGHAV 211
 
Name Accession Description Interval E-value
Aa_trans pfam01490
Transmembrane amino acid transporter protein; This transmembrane region is found in many amino ...
 52-281 1.25e-30

Transmembrane amino acid transporter protein; This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance. Other members of this family include proline transporters and amino acid permeases.


Pssm-ID: 279788  Cd Length: 410  Bit Score: 118.95  E-value: 1.25e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643719  52 KGITVFQALIHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGFIACHCMHILVKCAqRFCKRLNKPFMDYGDTVMHgl 131
Cdd:pfam01490   1 GTISAWQAVFNLINAIIGAGVLSLPYAFKQLGWIPGLILLLIVGLISLYTAHLLVRCS-KEVPVTGKRNKSYGDLGYR-- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034643719 132 eanpnawlqNHAHWGRHIVSFFLIITQLGFCCVYIVFLADNLKQVVEAVNSttnncysnetvilTPTMDSRLYMLSFLPF 211
Cdd:pfam01490  78 ---------LLGPKGRLLILFAILLNLFGVCISYLIFAGDNLPAIFDSFFD-------------TCPISLVYFIIIFGLI 135

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034643719 212 LVLLVLIRNLRILTIFSMLANISMLVSLVIIIQYITQEIPDPSRL-PLVASW-----KTYPLFFGTAIFSFESIGV 281
Cdd:pfam01490 136 FIPLSFIPNLSALSILSLLAAVSSLYYIVILVLSVAEGIVLTAQGvGHLGSKtniklAGTFLAIGIIVFAFEGHAV 211
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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