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Conserved domains on  [gi|1034648124|ref|XP_016865648|]
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sodium-dependent phosphate transport protein 3 isoform X6 [Homo sapiens]

Protein Classification

SLC17 family MFS transporter( domain architecture ID 13022888)

SLC17 (solute carrier 17) family major facilitator superfamily (MFS) transporter is involved in the transport of organic anions

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0016020|GO:0055085|GO:0015711
PubMed:  23506876|26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 1-439 2.80e-153

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 440.52  E-value: 2.80e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124   1 MHFSNFTMITQRVSLSIAIIAMVNttqqqglSNASTEGpvadafNNSSISIKEFDTKASVYQWSPETQGIIFSSINYGII 80
Cdd:cd17318     4 LFLGFAVVYAMRVNLSVAIVAMVN-------STATHDN------NNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  81 LTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTT 160
Cdd:cd17318    71 LTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 161 IAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTViyddpmhhpcisvrekehilsslaqqpsspgra 240
Cdd:cd17318   151 IAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL--------------------------------- 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 241 vpikamvtCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLR 320
Cdd:cd17318   198 --------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILS 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 321 LITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGII 400
Cdd:cd17318   270 TTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGII 349

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1034648124 401 SSTATGFLISQDF-ESGWRNVFFLSAAVNMFGLVFYLTFG 439
Cdd:cd17318   350 SPLIVGAIVKNDQtIGQWRIVFFISAAIYILGAIFYLIFG 389
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 1-439 2.80e-153

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 440.52  E-value: 2.80e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124   1 MHFSNFTMITQRVSLSIAIIAMVNttqqqglSNASTEGpvadafNNSSISIKEFDTKASVYQWSPETQGIIFSSINYGII 80
Cdd:cd17318     4 LFLGFAVVYAMRVNLSVAIVAMVN-------STATHDN------NNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  81 LTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTT 160
Cdd:cd17318    71 LTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 161 IAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTViyddpmhhpcisvrekehilsslaqqpsspgra 240
Cdd:cd17318   151 IAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL--------------------------------- 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 241 vpikamvtCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLR 320
Cdd:cd17318   198 --------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILS 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 321 LITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGII 400
Cdd:cd17318   270 TTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGII 349

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1034648124 401 SSTATGFLISQDF-ESGWRNVFFLSAAVNMFGLVFYLTFG 439
Cdd:cd17318   350 SPLIVGAIVKNDQtIGQWRIVFFISAAIYILGAIFYLIFG 389
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 1-454 3.33e-132

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 389.49  E-value: 3.33e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124   1 MHFSNFTMITQRVSLSIAIIAMVNTTQQQGLSNASTEGPVadafnnssisikeFDTKASVYQWSPETQGIIFSSINYGII 80
Cdd:TIGR00894  24 LHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENEL-------------DNIKNPNFKWSGALQGLILSSHFYGQI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  81 LTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTT 160
Cdd:TIGR00894  91 IIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 161 IAGSGSAFGSFIILCVGGLISQA-LSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILSSLAQQPSSPGR 239
Cdd:TIGR00894 171 MSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTRQ 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 240 AVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLL 319
Cdd:TIGR00894 251 SLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTL 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 320 RLITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGI 399
Cdd:TIGR00894 331 SLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGL 410

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034648124 400 ISSTATGFLISQDFESGWRNVFFLSAAVNMFGLVFYLTFGQAELQDWAKERTLTR 454
Cdd:TIGR00894 411 IASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
61-439 6.97e-29

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 116.51  E-value: 6.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  61 YQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWT 140
Cdd:COG2271    40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLL--RFLLGLGEAGFFP 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 141 GQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGstgcVCCLLWFTviyddpmhhpcisv 220
Cdd:COG2271   118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG----LPGLLLAL-------------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 221 rekehilsslaqqpsspgravpikamvtcLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAA 300
Cdd:COG2271   180 -----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 301 SCTILGGQLADFLLSRnllrlitvRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIpGTSNLCDSGFIINTLDIAP 380
Cdd:COG2271   231 VGSLLGGWLSDRLGRR--------RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG-FGLGGAFGLLWALAAELFP 301

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 381 -RYASFLMGISRGFGLIAGIISSTATGFLISQdfeSGWRNVFFLSAAVNMFGLVFYLTFG 439
Cdd:COG2271   302 kKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLL 358
MFS_1 pfam07690
Major Facilitator Superfamily;
58-402 2.99e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.41  E-value: 2.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  58 ASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVimVRTVQGMAQGM 137
Cdd:pfam07690  24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV--LRVLQGLGAGA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 138 AWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFtviyddpmhhpc 217
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL------------ 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 218 isVREKEHILSSLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTlLHVNIRDSGVLSSLPFI 297
Cdd:pfam07690 170 --LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 298 AAASCTILGGQLADFLLSRNLLRLITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFiintld 377
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA------ 320

                         330       340
                  ....*....|....*....|....*
gi 1034648124 378 iAPRYASFLMGISRGFGLIAGIISS 402
Cdd:pfam07690 321 -PKEERGTASGLYNTAGSLGGALGP 344
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 64-194 2.15e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 43.41  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  64 SPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVimVRTVQGMAQGMAWTGQF 143
Cdd:PRK11551   48 DVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLV--ARLLTGVGLGGALPNLI 125

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034648124 144 TIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFG 194
Cdd:PRK11551  126 ALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGG 176
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 1-439 2.80e-153

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 440.52  E-value: 2.80e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124   1 MHFSNFTMITQRVSLSIAIIAMVNttqqqglSNASTEGpvadafNNSSISIKEFDTKASVYQWSPETQGIIFSSINYGII 80
Cdd:cd17318     4 LFLGFAVVYAMRVNLSVAIVAMVN-------STATHDN------NNTSTDKDTLPVEAPEFDWSEKTQGIILSSFFYGYI 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  81 LTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTT 160
Cdd:cd17318    71 LTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTS 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 161 IAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTViyddpmhhpcisvrekehilsslaqqpsspgra 240
Cdd:cd17318   151 IAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFL--------------------------------- 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 241 vpikamvtCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLR 320
Cdd:cd17318   198 --------VLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILS 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 321 LITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGII 400
Cdd:cd17318   270 TTTVRKLFTSIGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGII 349

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1034648124 401 SSTATGFLISQDF-ESGWRNVFFLSAAVNMFGLVFYLTFG 439
Cdd:cd17318   350 SPLIVGAIVKNDQtIGQWRIVFFISAAIYILGAIFYLIFG 389
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 1-454 3.33e-132

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 389.49  E-value: 3.33e-132
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124   1 MHFSNFTMITQRVSLSIAIIAMVNTTQQQGLSNASTEGPVadafnnssisikeFDTKASVYQWSPETQGIIFSSINYGII 80
Cdd:TIGR00894  24 LHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENEL-------------DNIKNPNFKWSGALQGLILSSHFYGQI 90

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  81 LTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTT 160
Cdd:TIGR00894  91 IIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLG 170

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 161 IAGSGSAFGSFIILCVGGLISQA-LSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILSSLAQQPSSPGR 239
Cdd:TIGR00894 171 MSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQKGSTRQ 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 240 AVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLL 319
Cdd:TIGR00894 251 SLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTL 330

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 320 RLITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGI 399
Cdd:TIGR00894 331 SLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGL 410

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034648124 400 ISSTATGFLISQDFESGWRNVFFLSAAVNMFGLVFYLTFGQAELQDWAKERTLTR 454
Cdd:TIGR00894 411 IASTLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKDTR 465
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 1-439 1.45e-100

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 306.32  E-value: 1.45e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124   1 MHFSNFTMITQRVSLSIAIIAMVNTTQQQGLSNASTEGPvadafNNSSISIKEFDTKASVYQWSPETQGIIFSSINYGII 80
Cdd:cd17381     5 AFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACP-----EHSSSPSVEHNETGKKYDWDAETQGWILGSFFYGYI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  81 LTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTT 160
Cdd:cd17381    80 ITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 161 IAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIyddpmhhpcisvrekehilsslaqqpsspgra 240
Cdd:cd17381   160 ISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV-------------------------------- 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 241 vpikamvtcLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLR 320
Cdd:cd17381   208 ---------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFS 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 321 LITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGII 400
Cdd:cd17381   279 TVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMV 358

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1034648124 401 SSTATGFLISQDFESGWRNVFFLSAAVNMFGLVFYLTFG 439
Cdd:cd17381   359 GPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 12-439 1.73e-74

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 238.39  E-value: 1.73e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  12 RVSLSIAIIAMV-NTTQQQGLSNASTEgpvadafnnssisiKEFDtkasvyqWSPETQGIIFSSINYGIILTLIPSGYLA 90
Cdd:cd17382    15 RCNLGVAIVRMVnNFTDAYGGKVIVHK--------------AEFN-------WTPETVGLIESSFFWGYLVTQIPGGFIA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  91 GIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGS 170
Cdd:cd17382    74 AKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 171 FIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWftviyddpmhhpcisvrekehilsslaqqpsspgravpikaMVTCL 250
Cdd:cd17382   154 VVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFW-----------------------------------------MLVSM 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 251 PLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLRLITVRKLFSS 330
Cdd:cd17382   193 PVYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNC 272

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 331 LGLLLPSICAVALPFVaSSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGIISSTATGFLIS 410
Cdd:cd17382   273 GGFGMEATFLLVVAFS-HSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTK 351

                         410       420
                  ....*....|....*....|....*....
gi 1034648124 411 QDFESGWRNVFFLSAAVNMFGLVFYLTFG 439
Cdd:cd17382   352 HKTREEWQYVFLIASLVHFFGVIFYAIFA 380
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 58-439 5.04e-66

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 215.88  E-value: 5.04e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  58 ASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGM 137
Cdd:cd17380    26 AKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGV 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 138 AWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIyddpmhhpc 217
Cdd:cd17380   106 HFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL--------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 218 isvrekehilsslaqqpsspgravpikamvtcLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLhVNIRDSGVLSSLPFI 297
Cdd:cd17380   177 --------------------------------PPVWAIIVAHFCMNWGFYILLSWLPTYFHEVL-VPLAKGWVFNVVPWL 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 298 AAASCTILGGQLADFLLSRNLlRLITVRKLFSSLGLLLPSICAVALPFVaSSYVITIILLILIPGTSNLCDSGFIINTLD 377
Cdd:cd17380   224 VMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQD 301

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648124 378 IAPRYASFLMGISRGFGLIAGIISSTATGFLISQdfESGWRNVFFLSAAVNMFGLVFYLTFG 439
Cdd:cd17380   302 IAPNYAGIVFGISNTAGTIPGIVGVYLTGYILEA--TGSWSLVFVLAAVVNLVGAVVFLLFG 361
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
61-439 6.97e-29

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 116.51  E-value: 6.97e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  61 YQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWT 140
Cdd:COG2271    40 LGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLL--RFLLGLGEAGFFP 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 141 GQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGstgcVCCLLWFTviyddpmhhpcisv 220
Cdd:COG2271   118 AALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILG----LPGLLLAL-------------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 221 rekehilsslaqqpsspgravpikamvtcLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAA 300
Cdd:COG2271   180 -----------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 301 SCTILGGQLADFLLSRnllrlitvRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIpGTSNLCDSGFIINTLDIAP 380
Cdd:COG2271   231 VGSLLGGWLSDRLGRR--------RKLVLAIGLLLAALALLLLALLPSPALAIALLFLAG-FGLGGAFGLLWALAAELFP 301

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 381 -RYASFLMGISRGFGLIAGIISSTATGFLISQdfeSGWRNVFFLSAAVNMFGLVFYLTFG 439
Cdd:COG2271   302 kKARGTASGLVNTFGFLGGALGPLLVGYLLDA---TGYQAAFLLLAALALLAALLALLLL 358
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 62-437 1.51e-28

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 115.36  E-value: 1.51e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  62 QWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWTG 141
Cdd:cd17319    34 GLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVL--RFLLGVAEAGFFPG 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 142 QFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDdpmhhpcisvr 221
Cdd:cd17319   112 AIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ----------- 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 222 ekehilsslaqqpsspgravpikamvtclpLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAAS 301
Cdd:cd17319   181 ------------------------------VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAI 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 302 CTILGGQLADFLLSRNllrlitvRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGtSNLCDSGFIINTLDIAPR 381
Cdd:cd17319   231 GMILGGRLSDRLLRGA-------RRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFG-IGAASPVFWSLPADLLPG 302

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648124 382 -YASFLMGISRGFGLIAGIISSTATGFLIsqDFESGWRNVFFLSAAVNMFGLVFYLT 437
Cdd:cd17319   303 eAAATAGGLINSGGNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALLAALLVLL 357
MFS_1 pfam07690
Major Facilitator Superfamily;
58-402 2.99e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.41  E-value: 2.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  58 ASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVimVRTVQGMAQGM 137
Cdd:pfam07690  24 AEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLV--LRVLQGLGAGA 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 138 AWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFtviyddpmhhpc 217
Cdd:pfam07690 102 LFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLL------------ 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 218 isVREKEHILSSLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTlLHVNIRDSGVLSSLPFI 297
Cdd:pfam07690 170 --LPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGL 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 298 AAASCTILGGQLADFLLSRNLLRLITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFiintld 377
Cdd:pfam07690 247 LGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA------ 320

                         330       340
                  ....*....|....*....|....*
gi 1034648124 378 iAPRYASFLMGISRGFGLIAGIISS 402
Cdd:pfam07690 321 -PKEERGTASGLYNTAGSLGGALGP 344
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 58-436 7.01e-21

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 94.03  E-value: 7.01e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  58 ASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVrtVQGMAQGM 137
Cdd:cd06174    23 LQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRF--LLGLGSGL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 138 AWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQAL--SWPFIFYIFGSTGCVCCLLWFTVIYDDPMHH 215
Cdd:cd06174   101 IDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPDPPESA 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 216 PcisvreKEHILSSLAQQPSSPGRAVPIKamvtclPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLP 295
Cdd:cd06174   181 R------AKNEEASSKSVLKLLKRVLKNP------GLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLF 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 296 FIAAASCTILGGQLADFLLSRNLLRLItvrklfsslGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINT 375
Cdd:cd06174   249 GLAGALGSLLLGLLSDRLIGRKPLLLI---------GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034648124 376 LDIAPRYASFLMGISRGFGLIAGIISSTATGFLISQDFesGWRNVFFLSAAVNMFGLVFYL 436
Cdd:cd06174   320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATF--GLTGAFLVLAVLLLLAAILLL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 69-438 7.64e-20

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 90.71  E-value: 7.64e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  69 GIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVimVRTVQGMAQGMAWTGQFTIWAK 148
Cdd:cd17325    34 GLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL--ARFLQGLASAAVWPAAMALIAD 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 149 WAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIyddpmhhpcisvreKEHILS 228
Cdd:cd17325   112 IAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLL--------------PEPRPP 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 229 SLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQ 308
Cdd:cd17325   178 PNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 309 LADFLLSRnllRLITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLcdsgfiinTLDIAPRYA-SFLM 387
Cdd:cd17325   258 LSDRIGRK---PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLAL--------LADIVPPEGrGTAM 326

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034648124 388 GISRGFGLIAGIISSTATGFLISQdfeSGWRNVFFLSAAVNMFGLVFYLTF 438
Cdd:cd17325   327 GLFNTAFSLGMVLGPLLGGFLYDA---FGFATPFLAAAALLLLAAVLFLLL 374
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
58-366 2.94e-18

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 85.80  E-value: 2.94e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  58 ASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVimVRTVQGMAQGM 137
Cdd:COG2814    37 AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA--ARFLQGLGAGA 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 138 AWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIyddpmhhPC 217
Cdd:COG2814   115 LFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLL-------PE 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 218 ISVREKEHILSSLAQQPSSPGravpikamvtclpLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFI 297
Cdd:COG2814   188 SRPAARARLRGSLRELLRRPR-------------LLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGL 254

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034648124 298 AAASCTILGGQLADFLLSRNLLRLITvrkLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNL 366
Cdd:COG2814   255 GGVLGALLAGRLADRFGRRRLLLIGL---LLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQAL 320
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
61-434 1.32e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 78.38  E-value: 1.32e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  61 YQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVrtVQGMAQGMAWT 140
Cdd:COG2223    35 FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGL--LLGIGGGGSFA 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 141 GQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPcisv 220
Cdd:COG2223   113 VGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAA---- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 221 rekehilsslaqqPSSPGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAA 300
Cdd:COG2223   189 -------------AAAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGA 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 301 SCTILGGQLADFLLSRNLLrlitvrklfsSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAP 380
Cdd:COG2223   256 LGRPLGGWLSDRIGGRRVL----------LIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFP 325

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034648124 381 -RYASFLMGISRGFGLIAGIISSTATGFLIsqDFESGWRNVFFLSAAVNMFGLVF 434
Cdd:COG2223   326 tKNAGAVYGLVGAAGGLGGFLGPLLFGALL--DATGSYTAAFLVFAVLALVALVL 378
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 69-317 5.97e-13

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 70.10  E-value: 5.97e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  69 GIIFS--SINYGIilTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFtpLAADFGVILVIMVRTVQGMAQGMAWTGQFTIW 146
Cdd:TIGR00881  33 GLLLSsfSIAYGI--SKFVMGSVSDRSNPRVFLPIGLILCAIVNLF--FGFSTSLWVMAALWALNGIFQGMGWPPCGRTV 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 147 AKWAPPLERSKLTTIAGSGSAF-GSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHhPCISVREKEH 225
Cdd:TIGR00881 109 TKWFSRSERGTWVSFWNCSHNVgGGLLPPLVLFGIAELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPAEEMP 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 226 ILSSLAQQPSSPGRAVPIKAMVTCL----PLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAAS 301
Cdd:TIGR00881 188 NEEPDGDAEKKEEELTKKQIFLQYVllnkVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLV 267

                         250
                  ....*....|....*.
gi 1034648124 302 CTILGGQLADFLLSRN 317
Cdd:TIGR00881 268 GTLLAGWLSDKLFNGR 283
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 64-436 1.73e-12

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 68.34  E-value: 1.73e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  64 SPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWTGQF 143
Cdd:cd17324    32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA--RALAGLAHGGFWAIAA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 144 TIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVC-CLLWFTVIYDDPMHHPcisvre 222
Cdd:cd17324   110 AYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAaLLLWRLLPSLPPKKPG------ 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 223 kehILSSLAQQPSSPGRAVPIKAMVtclplwAIFLGFFSHFwlctIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASC 302
Cdd:cd17324   184 ---SLGLLSSLLLLLRNPRLRLAYL------ITFLLFGGFF----ALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVG 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 303 TILGGQLADFLLSRNLLrlitvrklfssLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRY 382
Cdd:cd17324   251 SPLAGRLADRGGRRALL-----------IALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEA 319

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034648124 383 ASFLMGISRGFGLIAGIISSTATGFLISQDfesGWRNVFFLSAAVNMFGLVFYL 436
Cdd:cd17324   320 RGLASSLYLAAYNLGGALGAALGGLVLDHG---GWAGVGWVGAALLLLALLLAL 370
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 64-315 2.73e-11

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 64.06  E-value: 2.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  64 SPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAadFGVILVIMVRTVQGMAQGMAWTGQF 143
Cdd:COG0477    47 SSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLA--PSPELLIAARALQGIGAGGLMPGAL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 144 TIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIfgstGCVCCLLWFTVIYDDPMHHPCISVREK 223
Cdd:COG0477   125 ALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI----NAPLGLLALVLRLRLPESRGLLLALLA 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 224 EHILSSLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCT 303
Cdd:COG0477   201 LALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLL 280

                         250
                  ....*....|..
gi 1034648124 304 ILGGQLADFLLS 315
Cdd:COG0477   281 LLLLLLLLLLLA 292
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 70-438 9.66e-10

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 59.98  E-value: 9.66e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  70 IIFSSINYGIILTLIP---------SGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVrtVQGMAQGMAWT 140
Cdd:cd17312    33 IGLSKDDLGIIGSAFLiayavgkfiSGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWG--LNGLFQSMGWP 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 141 GQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHhpcisv 220
Cdd:cd17312   111 PCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSPPY------ 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 221 rekehilsslaqqpsspgravpikamvtclpLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAA 300
Cdd:cd17312   185 -------------------------------VWVLSLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGI 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 301 SCTILGGQLAD--FLLSRNLLRLITVRKLFSSLGLLLpsicavalpFVASSYVITIILLILIPGTSNLCDSGF-IINTLD 377
Cdd:cd17312   234 AGTILAGLLSDklFGGRRAPIAVIYMLLMTLSLALFW---------FFPHNKLLSIVLLFLIGFFVGGPINLIgGAAAQD 304

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648124 378 IAPRYA-SFLMGISRGFGLIAGIISSTATGFLISQdfeSGWRNVFFLSAAVNMFGLVFYLTF 438
Cdd:cd17312   305 IGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDH---YGWSTVFYFLISAALLSVLLLLSL 363
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 69-347 1.36e-09

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 59.56  E-value: 1.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  69 GIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVrtVQGMAQGMAWTGQFTIWAK 148
Cdd:cd17475    34 GLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLF--LVGAGYGSVQPGGGRAIMR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 149 WAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGsTGCVCCLLWFTVIYDDPmhhpcisvrekehiLS 228
Cdd:cd17475   112 WFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAG-LVSILAAVLFWLFYREP--------------PA 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 229 SLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQ 308
Cdd:cd17475   177 ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGR 256

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1034648124 309 LADFLLSRNLLRLITVRKLFSSLGLLLPSICAVALPFVA 347
Cdd:cd17475   257 VSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWL 295
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 58-209 9.26e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 53.73  E-value: 9.26e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  58 ASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVrtVQGMAQGM 137
Cdd:cd17325   227 AELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA--LLGLGLGL 304

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648124 138 AWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTgCVCCLLWFTVIY 209
Cdd:cd17325   305 VFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAAL-LLLAAVLFLLLR 375
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 64-436 2.05e-07

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 52.60  E-value: 2.05e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  64 SPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAAdfGVILVIMVRTVQGMAQGMAWTGQF 143
Cdd:cd17489    29 SEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT--SVALLLVLRLIHGIGWGAFTTAAA 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 144 TIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTViyddpmhHPCISVREK 223
Cdd:cd17489   107 TLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLV-------KDPPPVAAE 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 224 EHILSSLAqqpssPGRAVPIKAMVTCLPLWAIFLGFFShfwlctiILTYLPTYISTLLHVNIrdsGVLSSLPFIAAASCT 303
Cdd:cd17489   180 EAEAGTRA-----FRRLVEKKVLPPALILFLASIAYGA-------ISTFLPLYAAERGISNA---GLFFTVYAIALLLSR 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 304 ILGGQLADFllsRNLLRLITVRKLFSSLGLLLPSICAVALPFVASSYVITIILLILIPGTSNLcdsgfiinTLDIAPRYA 383
Cdd:cd17489   245 PFSGKLSDR---KGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQAL--------AVDLVPPHR 313

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034648124 384 -SFLMGISRGFGLIAGIISSTATGFLISqdfESGWRNVFFLSAAVNMFGLVFYL 436
Cdd:cd17489   314 rGAANGTFFIFFDLGIGLGGLLLGLVAE---LFGYRAMFLLAAVVVLLALVLYI 364
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 43-404 4.65e-07

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 51.87  E-value: 4.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  43 AFNNSSISIKEFDTKASVYQWSpetqgIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVI 122
Cdd:cd17327    23 NISNAAVMGMKEDLKLVGNQYN-----WGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGL 97

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 123 LVimVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTI----AGSGSAFGSFI------ILCVGGLisqaLSWPFIFYI 192
Cdd:cd17327    98 IA--LRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFfyaaAGLGSIFGGLLaygvfkILGVGGL----AGWRWLFII 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 193 FGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILSSLAQQPSSPGRAVP----IKAMVTCLPLWAIFLGFFSHFWLCTI 268
Cdd:cd17327   172 EGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFkwkqIKEAFKDPRTWLLFLFFFCSQITNNG 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 269 ILTYLPTYISTLLHVNIrDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLrlitvrKLFSSLGLLLPSICAVALPFVAS 348
Cdd:cd17327   252 ISNFLPLILKSLGFYSL-QTNLLSVPIGALGAVSLLIAALLSDRFKKRGLF------AIFACVLALVGSIILLAAPNPPG 324

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034648124 349 SYVITIILLILIPGTSNLCdSGFIINTLDIAPRYASFLmGISRGFGLIAGIISSTA 404
Cdd:cd17327   325 AYFAAYILGGGSYAGFPIL-LSWISSNCAGYTKRATVL-AIMLIFYNVGNIVAPQI 378
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 69-324 7.49e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 51.17  E-value: 7.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  69 GIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAK 148
Cdd:cd17333    34 SVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALF 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 149 WAPPLER-SKLTTIAGSGSAFGSFIIlcvGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDpmhhpcisvrekehiL 227
Cdd:cd17333   114 EESSATRlNVLHGFFGLGALIGPLIA---TSLLTSELSWSWAYLIIGLIYLLLAILILLTLFPE---------------L 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 228 SSLAQQPSSPGRAVPIKAMVtclpLWAIFLGFFSHFWLC-----TIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASC 302
Cdd:cd17333   176 PSARNPQQSVGAFSASASRL----LRNPSIILGALALFLyvgaeTAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIG 251

                         250       260
                  ....*....|....*....|..
gi 1034648124 303 TILGGQLADFLLSRNLLRLITV 324
Cdd:cd17333   252 RLLGGPISRRIKPHTLLVLSGS 273
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 82-192 8.15e-07

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 51.04  E-value: 8.15e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  82 TLIP-SGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVIlvIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTT 160
Cdd:cd17503    46 IMIPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASL--IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMG 123

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1034648124 161 IAGSGSAFGSFIILCVGGLISQALSWPFIFYI 192
Cdd:cd17503   124 LVGLVILLAPAIGPTLGGWLTDNLSWRWIFYI 155
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
60-438 1.33e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 50.24  E-value: 1.33e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  60 VYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVrtVQGMAQGMAW 139
Cdd:COG0738    37 AFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALF--LLGLGLGLLD 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 140 TGQFTIwAKWAPPLERSKLTTIAGSGSAFGSFI-ILCVGGLISQALS--WPFIFYIFGSTGCVCCLLWFTVIYDDPMHHP 216
Cdd:COG0738   115 VAANPY-VAALGPETAASRLNLLHAFFSLGALLgPLLGGLLILLGLSlsWHLPYLILAVLLLLLALLFLRSKLPEIEEEE 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 217 cisvrekehilSSLAQQPSSPGRAVPIKAmvtclpLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPF 296
Cdd:COG0738   194 -----------EEAAGSAASLKSLLKNPR------LLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFW 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 297 IAAASCTILGGQLADFLLSRNLLRLITVRKLFSSLGLLLPSICAVALPFVASSYVitiillilipGTSNLCDSGFIInTL 376
Cdd:COG0738   257 GGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGL----------GLSLMFPTIFSL-AL 325

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648124 377 DIAPRYASFLMGISRGFGLIAGIISSTATGFLISQdfeSGWRNVFFLSAAvnMFGLVFYLTF 438
Cdd:COG0738   326 DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADA---FGLRAAFLVPLV--CYLLILLLAL 382
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 82-215 5.40e-06

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 48.53  E-value: 5.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  82 TLIP-SGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFgvILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTT 160
Cdd:TIGR00711  52 ISIPlTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNL--ELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMA 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034648124 161 IAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGC-VCCLLWFTVIYDDPMHH 215
Cdd:TIGR00711 130 IWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGIiVVVVAFFILPRDKPAAS 185
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 73-208 7.86e-06

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 48.09  E-value: 7.86e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  73 SSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWTGQFTIWAKWAPP 152
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--RLLVGMGIGGIWVQAVVLNTEFLPK 211

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034648124 153 LERSKLTTIAGSGSAFGSFIILCVGGLISQ------ALSWPFIfyifgstgcVCCLLWFTVI 208
Cdd:TIGR00898 212 KQRAIVGTLIQVFFSLGLVLLPLVAYFIPDwrwlqlAVSLPTF---------LFFLLSWFVP 264
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 78-335 1.06e-05

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 47.57  E-value: 1.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  78 GIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVimVRTVQGMAQGMAWTGQFTIWAKWAPPLERSK 157
Cdd:cd17473    47 FIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLA--SRALLGIGVAGIMTLATALIGDYFEGEERAK 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 158 LTTIAGSGSAFGSFIILCVGGLISQaLSWPFIFYIFGSTGCVCCLLWFTViyddpmhhPCISVREKEHILSSLAQQPSSP 237
Cdd:cd17473   125 MLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFL--------PEPARKSKSAASPGAATAAALP 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 238 GRAVPIKAMVTCLplwaIFLGFFshfwlctIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRN 317
Cdd:cd17473   196 WKRVLPIYFLAFL----AMLLFY-------VIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRR 264

                         250
                  ....*....|....*...
gi 1034648124 318 LLRLITVrklFSSLGLLL 335
Cdd:cd17473   265 LLAIGFA---LMALGFLL 279
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
58-208 1.19e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 1.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  58 ASVYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGA--KKMLGAGLLISSLLTLFTPLAADFGVILVIMVrtVQGMAQ 135
Cdd:COG2271   208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLF--LAGFGL 285

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034648124 136 GMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVI 208
Cdd:COG2271   286 GGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 64-203 2.08e-05

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 46.40  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  64 SPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWTGQF 143
Cdd:cd17321    29 SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAA--RALQGIGAAAIMPASL 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 144 TIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLL 203
Cdd:cd17321   107 ALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL 166
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 83-206 2.85e-05

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 46.10  E-value: 2.85e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  83 LIPSGYLAGIFGAKKMLGAGlliSSLLTLFTpLAADF--GVILVIMVRTVQGMAQGMAWTGQFTIWAK-WAPPLERSKLT 159
Cdd:cd17476    50 ILIFGRLGDIYGHKKMFVIG---SFWFAIWS-LIAGFspNFIFFIICRALQGLGPAFLLPNAMALLGRtYPPGPRKNIVF 125

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034648124 160 TIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFG---STGCVCCLLWFT 206
Cdd:cd17476   126 SLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAilaAIVAVAAIFWTS 175
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 61-313 4.99e-05

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 45.31  E-value: 4.99e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  61 YQWSPETQGIIFS--SINYGIILTLipSGYLAGIFGAKKMLGAGLLISSLLTLFTPLA----ADFGVILVIMVrtVQGMA 134
Cdd:cd17345    33 YGLSKTEIGLIGSalSIAYGLSKFV--MGNLSDRSNPKRFLAIGLILSAIINILIGFVpsatSSVGLMFILLF--LNGWF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 135 QGMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQAL---SWPFIFYIFGSTGCVCCLLWFTVIYDD 211
Cdd:cd17345   109 QGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgdgWWRGAFIFPAIIAIIVAVIVLFLGKDT 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 212 PmhhpcisvreKEHILSSLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFF---SHFWLCTI-----------ILTYLPTYI 277
Cdd:cd17345   189 P----------ESEGLPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYVlknKLLWYIAIanvfvylvrygILDWAPTYL 258

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1034648124 278 STLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFL 313
Cdd:cd17345   259 SEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKL 294
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 84-349 6.07e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 45.30  E-value: 6.07e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  84 IPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTIAG 163
Cdd:cd17328    52 PIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLF--RALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFY 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 164 SGSAFGSFIILCVGGLISQA-LSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCISVREKEHILSSLAQqpsspgravp 242
Cdd:cd17328   130 FAIPLGSGLGYVVGGLVAQAtGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLAD---------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 243 IKAMVTCLPLWAIFLGF----FSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNl 318
Cdd:cd17328   200 LKALAKNPSFILSTLGFtavsFVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKT- 278

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1034648124 319 lrlITVRKLFSSLGLLLPSICAVALPFVASS 349
Cdd:cd17328   279 ---PRADPLVCAVGLLAAAPFLFLALVLALS 306
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 78-351 8.81e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 44.48  E-value: 8.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  78 GIILTLIpSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWTGQFTIWAKWAPPLERSK 157
Cdd:cd17474    47 AAVLMPV-AGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG--RALQGIGAAGLGPLALTLIGDLFEGGERAK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 158 ----LTTIAGSGSAFGSFIilcvGGLISqALSWPFIFYIFGSTGCVccLLWFTVIYDDPMHHPcisvrekehilsslAQQ 233
Cdd:cd17474   124 amglYEAALGLGIAVGPLL----GGLLA-AISWRYPFFLLAALIPV--AFLAILFLLPEPKEK--------------AKS 182

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 234 PSSPGRAVPIKAMvTCLPLWAIFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIA-AASCTILGGQLADF 312
Cdd:cd17474   183 SSATKLRDLKKAL-RGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLlALGSLFVGRLLKKR 261

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1034648124 313 LLSRNLLRlitvrklfssLGLLLPSICAVALPFVASSYV 351
Cdd:cd17474   262 FGARRILV----------IGLLLYALSLLLLGFVPSLAL 290
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 64-411 9.15e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.51  E-value: 9.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  64 SPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFgvILVIMVRTVQGMAQGMAWTGQF 143
Cdd:cd17316    34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTP--ILLLVLRFLQGIGIGGEYPGAS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 144 TIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPF---IFYIFGSTGCVCCLLWFtviyddpmhhpcisv 220
Cdd:cd17316   112 TYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGDWgwrILFLIGALPALLALLLR--------------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 221 rekehilsslaqqpsspgravpiKAMVTCLPLWAIFLGFFshfwlcTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAA 300
Cdd:cd17316   177 -----------------------RRTLLLILLWFFISFGY------YGLTTFLPTYLQTVLGLSPATSSLYLLLISLGAL 227

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 301 SCTILGGQLADFLlsrnllrlitVRKLFSSLGLLLPSICAVALPFVASSYVITIILLIL-IPGTSNLCDSGFIINTLDIA 379
Cdd:cd17316   228 VGALIAGLLSDRI----------GRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFiLSFFVGGVWGALYAYLAELF 297

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1034648124 380 P-RYASFLMGISRGFGLIAGIISSTATGFLISQ 411
Cdd:cd17316   298 PtEVRATGVGLSYNLGRLGGGGAPPLIALLLAS 330
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 64-208 1.26e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 44.11  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  64 SPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWTGQF 143
Cdd:cd17365    32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALL--RFLTGLGLGAAMPNAI 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034648124 144 TIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVI 208
Cdd:cd17365   110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPLLRGTL 174
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 62-223 1.69e-04

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 43.83  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  62 QWSPETQGIIfSSINY-GIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWT 140
Cdd:cd06180    30 GLSYAQAGWI-ATANYaGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMALTSGFAALLAL--RFLAGAASAFVFV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 141 GQFTIWAKWAPPLERSKLTTIAGSGSAFGSFII-LCVGGLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDPMHHPCIS 219
Cdd:cd06180   107 FGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSgLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPTEAS 186


                  ....
gi 1034648124 220 VREK 223
Cdd:cd06180   187 AAES 190
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 64-194 2.15e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 43.41  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  64 SPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVimVRTVQGMAQGMAWTGQF 143
Cdd:PRK11551   48 DVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLV--ARLLTGVGLGGALPNLI 125

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034648124 144 TIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFG 194
Cdd:PRK11551  126 ALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGG 176
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 60-206 3.97e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 42.60  E-value: 3.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  60 VYQWSPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVIMVrtVQGMAQGMAW 139
Cdd:cd06173   238 VLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALF--LLGLAGGLFN 315

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034648124 140 TGQFTIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVCCLLWFT 206
Cdd:cd06173   316 VPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 52-192 5.57e-04

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 42.18  E-value: 5.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  52 KEFDTKASVYQWspetqgIIFSSINYGIILTLIpSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQ 131
Cdd:cd17504    24 REFGTSAAAVSW------VLTAYLLVGAVSTPI-LGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAG--RALQ 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034648124 132 GMAQGMAWTGQFTIWAKWAPPLERSKLTTIAGSGSAfGSFIILCVGGLISQALSWPFIFYI 192
Cdd:cd17504    95 GIGGAVFPLAFALVREEFPPERVPVAQGILSATFGI-GAGIGLPLGGWIVQHLGWRWIFWT 154
MFS_1 pfam07690
Major Facilitator Superfamily;
255-438 1.10e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 40.86  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 255 IFLGFFSHFWLCTIILTYLPTYISTLLHVNIRDSGVLSSLPFIAAASCTILGGQLADFLLSRNLLrlitvrklfsSLGLL 334
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVL----------LIGLL 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 335 LPSICAVALPFVASSYVITIILLILIPGTSNLCDSGFIINTLDIAPRYASFLMGISRGFGLIAGIISSTATGFLISQdfe 414
Cdd:pfam07690  71 LFALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL--- 147

                         170       180
                  ....*....|....*....|....
gi 1034648124 415 SGWRNVFFLSAAVNMFGLVFYLTF 438
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLP 171
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
 69-212 1.66e-03

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 40.78  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  69 GIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFtpLAADFGVILVIMVRTVQGMAQGMAWTGQFTIWAK 148
Cdd:cd17343    41 GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVA--FSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRK 118

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034648124 149 WAPPLE----RSKLTTIAGSGSAFGSFIILcvggLISQALSWPFIFYIFGSTGCVCCLLWFTVIYDDP 212
Cdd:cd17343   119 WFSPSQfgtwWSVLSTSMNLAGSLGPILAT----LLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEP 182
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 87-192 1.78e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 40.24  E-value: 1.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  87 GYLAGIFGAKKMLGAGL---LISSLLTLFTPlaadfGVILVIMVRTVQGMAQGMAWTGQFTIWAKWAPPLERSKLTTIAG 163
Cdd:cd17502    51 GKLSDLFGRKWVLLIAIvifELGSLLCGLAP-----NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIG 125

                          90       100
                  ....*....|....*....|....*....
gi 1034648124 164 SGSAFGSFIILCVGGLISQALSWPFIFYI 192
Cdd:cd17502   126 AVFGIASVAGPLIGGAFTDHLSWRWCFYI 154
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 64-347 5.15e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 38.88  E-value: 5.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124  64 SPETQGIIFSSINYGIILTLIPSGYLAGIFGAKKMLGAGLLISSLLTLFTPLAADFGVILVImvRTVQGMAQGMAWTGQF 143
Cdd:TIGR00895  50 DPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL--RFLAGLGLGGLMPNLN 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 144 TIWAKWAPPLERSKLTTIAGSGSAFGSFIILCVGGLISQALSWPFIFYIFGSTGCVccLLWFTVIYddpMHHPCISVREK 223
Cdd:TIGR00895 128 ALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPLL--LLLLLMRF---LPESIDFLVSK 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034648124 224 E---------HILSSLAQQPSSPGRAVPIKAMVTCLPLWAIFLGFFSH----FWLCTIILTYLPTYISTLLHVNIRDSGV 290
Cdd:TIGR00895 203 RpetvrrivnAIAPQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARitvlLWLLYFMLLVGVYFLTNWLPKLMVELGF 282

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034648124 291 LSSLPFI-------AAASCTILGGQLADFLLSRNLLRLITVRKLFSSLGLLLPSICAVALPFVA 347
Cdd:TIGR00895 283 SLSLAATggalfnfGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGA 346
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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