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Conserved domains on  [gi|1034660530|ref|XP_016869007|]
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regulator of microtubule dynamics protein 1 isoform X5 [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
145-286 1.17e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 145 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAkianayiiKEHFEKAIELNPKDATSIHLMGIWCYTFAEmpwy 224
Cdd:COG0457    26 EAIEDYEKALELDPDDAEALYNLGLAYLRLGRYE--EA--------LADYEQALELDPDDAEALNNLGLALQALGR---- 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034660530 225 qrriakmlfatppsstYEKALGYFHRAEQVDPNfYSKNLLLLGKTYLKLHNKKLAAFWLMKA 286
Cdd:COG0457    92 ----------------YEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERA 136
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
145-286 1.17e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 145 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAkianayiiKEHFEKAIELNPKDATSIHLMGIWCYTFAEmpwy 224
Cdd:COG0457    26 EAIEDYEKALELDPDDAEALYNLGLAYLRLGRYE--EA--------LADYEQALELDPDDAEALNNLGLALQALGR---- 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034660530 225 qrriakmlfatppsstYEKALGYFHRAEQVDPNfYSKNLLLLGKTYLKLHNKKLAAFWLMKA 286
Cdd:COG0457    92 ----------------YEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERA 136
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 145-207 6.62e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 41.07  E-value: 6.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034660530 145 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgikakiaNAYiikEHFEKAIELNPKDATS 207
Cdd:cd24142    18 LALKFLQRALELEPNNVEALELLGEILLELGDVE-------EAR---EVLLRAIELDPDGGYE 70
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
145-286 1.17e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.32  E-value: 1.17e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 145 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAkianayiiKEHFEKAIELNPKDATSIHLMGIWCYTFAEmpwy 224
Cdd:COG0457    26 EAIEDYEKALELDPDDAEALYNLGLAYLRLGRYE--EA--------LADYEQALELDPDDAEALNNLGLALQALGR---- 91

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034660530 225 qrriakmlfatppsstYEKALGYFHRAEQVDPNfYSKNLLLLGKTYLKLHNKKLAAFWLMKA 286
Cdd:COG0457    92 ----------------YEEALEDYDKALELDPD-DAEALYNLGLALLELGRYDEAIEAYERA 136
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
145-289 7.20e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 50.01  E-value: 7.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 145 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAKianayiikEHFEKAIELNPKDATSIHLMGiWCYTFAEMpwy 224
Cdd:COG0457    60 EALADYEQALELDPDDAEALNNLGLALQALGRYE--EAL--------EDYDKALELDPDDAEALYNLG-LALLELGR--- 125

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034660530 225 qrriakmlfatppsstYEKALGYFHRAEQVDPNfYSKNLLLLGKTYLKLHNKKLAAFWLMKAKDY 289
Cdd:COG0457   126 ----------------YDEAIEAYERALELDPD-DADALYNLGIALEKLGRYEEALELLEKLEAA 173
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 87-286 6.88e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.03  E-value: 6.88e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530  87 LEQADYLYESG---ETEKLYQLLTQyKESEDAELLWRLARAsrdvaqLSRTSEEEKkllvyeALEYAKRALEKNESSFAS 163
Cdd:COG2956    80 LELAQDYLKAGlldRAEELLEKLLE-LDPDDAEALRLLAEI------YEQEGDWEK------AIEVLERLLKLGPENAHA 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 164 HKWYAICLSDVGDYEgiKAKianayiikEHFEKAIELNPKDAtsihlmgiwcytfaempWYQRRIAKMLFATppsSTYEK 243
Cdd:COG2956   147 YCELAELYLEQGDYD--EAI--------EALEKALKLDPDCA-----------------RALLLLAELYLEQ---GDYEE 196

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034660530 244 ALGYFHRAEQVDPNfYSKNLLLLGKTYLKLHNKKLAAFWLMKA 286
Cdd:COG2956   197 AIAALERALEQDPD-YLPALPRLAELYEKLGDPEEALELLRKA 238
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 80-258 1.05e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.80  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530  80 TAKVEEILEQADYLYESGETEKLYQLLTQY--KESEDAELLWRLARASRDVAQLSrtseeekkllvyEALEYAKRALEKN 157
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKAleLDPDNPEAFALLGEILLQLGDLD------------EAIVLLHEALELD 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 158 ESSFASHKWYAICLSDVGDYEgiKAkianayiiKEHFEKAIELNPKDatsihlmgiwcytfaemPWYQRRIAKMLFATPp 237
Cdd:COG4783    69 PDEPEARLNLGLALLKAGDYD--EA--------LALLEKALKLDPEH-----------------PEAYLRLARAYRALG- 120

                         170       180
                  ....*....|....*....|.
gi 1034660530 238 ssTYEKALGYFHRAEQVDPNF 258
Cdd:COG4783   121 --RPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 73-275 8.10e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 8.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530  73 QAAVVHATAKVEEILEQADYLYESGEtekLYQLLTQYKESEDAELLWRLARASRDVAQLSRTSEEEKKLLVY-------- 144
Cdd:COG3914    18 LAAAAAAELALAAELEAAALAAALGL---ALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALllqalgry 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 145 -EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAkianayiiKEHFEKAIELNPKDATSIHLMGiwcytfaempw 223
Cdd:COG3914    95 eEALALYRRALALNPDNAEALFNLGNLLLALGRLE--EA--------LAALRRALALNPDFAEAYLNLG----------- 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034660530 224 yqrriaKMLFATppsSTYEKALGYFHRAEQVDPNfYSKNLLLLGKTYLKLHN 275
Cdd:COG3914   154 ------EALRRL---GRLEEAIAALRRALELDPD-NAEALNNLGNALQDLGR 195
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 87-279 1.32e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 43.18  E-value: 1.32e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530  87 LEQADYLYESGETEKLYQLLTQYKESED--AELLWRLARASRDVAQLSRtseeekkllvyeALEYAKRALEKNESSFASH 164
Cdd:COG2956    46 LALGNLYRRRGEYDRAIRIHQKLLERDPdrAEALLELAQDYLKAGLLDR------------AEELLEKLLELDPDDAEAL 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 165 KWYAICLSDVGDYEgiKAKianayiikEHFEKAIELNPKDAtsihlmgiwcytfaempWYQRRIAKMLFATppsSTYEKA 244
Cdd:COG2956   114 RLLAEIYEQEGDWE--KAI--------EVLERLLKLGPENA-----------------HAYCELAELYLEQ---GDYDEA 163

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1034660530 245 LGYFHRAEQVDPNfYSKNLLLLGKTYLKLHNKKLA 279
Cdd:COG2956   164 IEALEKALKLDPD-CARALLLLAELYLEQGDYEEA 197
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
145-259 1.61e-04

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 40.15  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 145 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAkianayiikEHFEKAIELNPKDATSIHLMgiwcytfAEMPWY 224
Cdd:COG3063    10 EAEEYYEKALELDPDNADALNNLGLLLLEQGRYD--EA---------IALEKALKLDPNNAEALLNL-------AELLLE 71

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1034660530 225 QRRiakmlfatppsstYEKALGYFHRAEQVDPNFY 259
Cdd:COG3063    72 LGD-------------YDEALAYLERALELDPSAL 93
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 73-292 2.25e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.06  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530  73 QAAVVHATAKVEEILEQADYLYESG---ETEKLYQLLTQYKeSEDAELLWRLARASRDVAQLSrtseeekkllvyEALEY 149
Cdd:COG3914   102 RRALALNPDNAEALFNLGNLLLALGrleEALAALRRALALN-PDFAEAYLNLGEALRRLGRLE------------EAIAA 168

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 150 AKRALEKNESSFASHKWYAICLSDVGDY-EGIkakianayiikEHFEKAIELNPKDATSIHLMGIWCYTFAEMPWYQRRI 228
Cdd:COG3914   169 LRRALELDPDNAEALNNLGNALQDLGRLeEAI-----------AAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFE 237

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034660530 229 AKMlfATPPSSTYEKALGYFHRAEQVDPnfysKNLLLLGKTYLKLHNKKLAAFWLMKAKDYPAH 292
Cdd:COG3914   238 ELL--AALARGPSELSPFALLYLPDDDP----AELLALARAWAQLVAAAAAPELPPPPNPRDPD 295
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 145-207 6.62e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 41.07  E-value: 6.62e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034660530 145 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgikakiaNAYiikEHFEKAIELNPKDATS 207
Cdd:cd24142    18 LALKFLQRALELEPNNVEALELLGEILLELGDVE-------EAR---EVLLRAIELDPDGGYE 70
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 145-286 1.90e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 38.25  E-value: 1.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 145 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAKianayiikEHFEKAIELNPKDatsihlmgiwcytfaemPWY 224
Cdd:COG4783    22 EAEALLEKALELDPDNPEAFALLGEILLQLGDLD--EAI--------VLLHEALELDPDE-----------------PEA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034660530 225 QRRIAKMLFAtppSSTYEKALGYFHRAEQVDPNFYSKnLLLLGKTYLKLHNKKLAAFWLMKA 286
Cdd:COG4783    75 RLNLGLALLK---AGDYDEALALLEKALKLDPEHPEA-YLRLARAYRALGRPDEAIAALEKA 132
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 87-213 2.00e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530  87 LEQADYLYESGETEKLYQLLTQYKESEDAELLWRLARASRDVAQLSRTSEEEKKLLVY-------EALEYAKRALEKNES 159
Cdd:COG5010     7 FDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYnklgdfeESLALLEQALQLDPN 86

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034660530 160 SFASHKWYAICLSDVGDYEgiKAkianayiiKEHFEKAIELNPKDATSIHLMGI 213
Cdd:COG5010    87 NPELYYNLALLYSRSGDKD--EA--------KEYYEKALALSPDNPNAYSNLAA 130
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 113-286 2.06e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 113 EDAELLWRLARASRDVAQLSRTSEEEKKLLVYEALEYAKRALEKNESSFASHKWYAICLSDVGDYEGIKAkianayiike 192
Cdd:COG5010     6 GFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLA---------- 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 193 HFEKAIELNPKDATSIHLMGiWCYTFAEMpwyqrriakmlfatppsstYEKALGYFHRAEQVDPNfYSKNLLLLGKTYLK 272
Cdd:COG5010    76 LLEQALQLDPNNPELYYNLA-LLYSRSGD-------------------KDEAKEYYEKALALSPD-NPNAYSNLAALLLS 134

                         170
                  ....*....|....
gi 1034660530 273 LHNKKLAAFWLMKA 286
Cdd:COG5010   135 LGQDDEAKAALQRA 148
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 145-280 6.82e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.52  E-value: 6.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034660530 145 EALEYAKRALEKNESSFASHKWYAICLSDVGDYEgiKAKIAnayiikehFEKAIELNPKDATsihlmgiwcytfaempwY 224
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYD--EALAA--------YEKALRLDPDNAD-----------------A 53

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034660530 225 QRRIAKMLFAtppSSTYEKALGYFHRAEQVDPNFYsKNLLLLGKTYLKLHNKKLAA 280
Cdd:COG4235    54 LLDLAEALLA---AGDTEEAEELLERALALDPDNP-EALYLLGLAAFQQGDYAEAI 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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