NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034663467|ref|XP_016869666|]
View 

rab9 effector protein with kelch motifs isoform X2 [Homo sapiens]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
13-270 3.10e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 111.40  E-value: 3.10e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  13 PRKATWYTLtvpGDSPCARVGHSCSYLPpvgnakRGKVFIVGGANPN----RSFSDVHTMDLGKHQWdldTCKGLLP--R 86
Cdd:COG3055    45 PATNTWSEL---APLPGPPRHHAAAVAQ------DGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPtpR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  87 YEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvq 166
Cdd:COG3055   113 GGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 167 dtklhvFDANTLTWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGdrFYDDLHCIDISDMKWQKLNPTgaaPAGCAAH 246
Cdd:COG3055   180 ------GSGFSNTWT---TLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGEL---PTPRHGH 245

                         250       260
                  ....*....|....*....|....
gi 1034663467 247 SAVAMGKHVYIFGGMTPAGALDTM 270
Cdd:COG3055   246 AAVLTDGKVYVIGGETKPGVRTPL 269
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
13-270 3.10e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 111.40  E-value: 3.10e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  13 PRKATWYTLtvpGDSPCARVGHSCSYLPpvgnakRGKVFIVGGANPN----RSFSDVHTMDLGKHQWdldTCKGLLP--R 86
Cdd:COG3055    45 PATNTWSEL---APLPGPPRHHAAAVAQ------DGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPtpR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  87 YEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvq 166
Cdd:COG3055   113 GGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 167 dtklhvFDANTLTWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGdrFYDDLHCIDISDMKWQKLNPTgaaPAGCAAH 246
Cdd:COG3055   180 ------GSGFSNTWT---TLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGEL---PTPRHGH 245

                         250       260
                  ....*....|....*....|....
gi 1034663467 247 SAVAMGKHVYIFGGMTPAGALDTM 270
Cdd:COG3055   246 AAVLTDGKVYVIGGETKPGVRTPL 269
PLN02193 PLN02193
nitrile-specifier protein
 126-280 2.81e-20

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 91.94  E-value: 2.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 126 WTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVqDTKLHVFDANTLTWS-QPETLGNPPSPRHGHVMVAAGTK 204
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034663467 205 LFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 280
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
Kelch_3 pfam13415
Galactose oxidase, central domain;
149-201 1.26e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 1.26e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034663467 149 GNQLYVFGGGERGAQPVqDTKLHVFDANTLTWsqpETLGNPPSPRHGHVMVAA 201
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR-LNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
13-270 3.10e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 111.40  E-value: 3.10e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  13 PRKATWYTLtvpGDSPCARVGHSCSYLPpvgnakRGKVFIVGGANPN----RSFSDVHTMDLGKHQWdldTCKGLLP--R 86
Cdd:COG3055    45 PATNTWSEL---APLPGPPRHHAAAVAQ------DGKLYVFGGFTGAnpssTPLNDVYVYDPATNTW---TKLAPMPtpR 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  87 YEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGGGErgaqpvq 166
Cdd:COG3055   113 GGATALLLD---GKIYVVGGWDDGGNVAWVEVYDPATGTWTQ---LAPLPTPRDHLAAAVLPDGKILVIGGRN------- 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 167 dtklhvFDANTLTWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGdrFYDDLHCIDISDMKWQKLNPTgaaPAGCAAH 246
Cdd:COG3055   180 ------GSGFSNTWT---TLAPLPTARAGHAAAVLGGKILVFGGESG--FSDEVEAYDPATNTWTALGEL---PTPRHGH 245

                         250       260
                  ....*....|....*....|....
gi 1034663467 247 SAVAMGKHVYIFGGMTPAGALDTM 270
Cdd:COG3055   246 AAVLTDGKVYVIGGETKPGVRTPL 269
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
85-269 8.74e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 104.85  E-value: 8.74e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  85 PRYEHASFIPSctpDRIWVFGGANQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAAIGNQLYVFGG-GERGAQ 163
Cdd:COG3055    12 PRSEAAAALLD---GKVYVAGGLSGGSASNSFEVYDPATNTWSE---LAPLPGPPRHHAAAVAQDGKLYVFGGfTGANPS 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 164 PVQDTKLHVFDANTLTWSQpetLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGC 243
Cdd:COG3055    86 STPLNDVYVYDPATNTWTK---LAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHL 162

                         170       180
                  ....*....|....*....|....*.
gi 1034663467 244 AAhsAVAMGKHVYIFGGMTPAGALDT 269
Cdd:COG3055   163 AA--AVLPDGKILVIGGRNGSGFSNT 186
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
48-283 2.47e-24

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 100.62  E-value: 2.47e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  48 GKVFIVGGANPNRSFSDVHTMDLGKHQW----DLDTckglLPRYEHASFIPSctpDRIWVFGGANQSGNRNCLQ----VL 119
Cdd:COG3055    23 GKVYVAGGLSGGSASNSFEVYDPATNTWselaPLPG----PPRHHAAAVAQD---GKLYVFGGFTGANPSSTPLndvyVY 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 120 NPETRTWTTpevTSPPPSPRTFHTsSAAIGNQLYVFGggerGAQPVQDTKLH-VFDANTLTWSQpetLGNPPSPRHGH-V 197
Cdd:COG3055    96 DPATNTWTK---LAPMPTPRGGAT-ALLLDGKIYVVG----GWDDGGNVAWVeVYDPATGTWTQ---LAPLPTPRDHLaA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 198 MVAAGTKLFIHGGLAGDRFYDdlhcidisdmKWQKLNPtgaAPAGCAAHSAVAMGKHVYIFGGMTpaGALDTMYQYHTEE 277
Cdd:COG3055   165 AVLPDGKILVIGGRNGSGFSN----------TWTTLAP---LPTARAGHAAAVLGGKILVFGGES--GFSDEVEAYDPAT 229


                  ....*.
gi 1034663467 278 QHWTLL 283
Cdd:COG3055   230 NTWTAL 235
PLN02193 PLN02193
nitrile-specifier protein
 126-280 2.81e-20

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 91.94  E-value: 2.81e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 126 WTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVqDTKLHVFDANTLTWS-QPETLGNPPSPRHGHVMVAAGTK 204
Cdd:PLN02193  153 WIKVEQKGEGPGLRCSH-GIAQVGNKIYSFGGEFTPNQPI-DKHLYVFDLETRTWSiSPATGDVPHLSCLGVRMVSIGST 230

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034663467 205 LFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHW 280
Cdd:PLN02193  231 LYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW 306
PLN02153 PLN02153
epithiospecifier protein
 136-279 1.57e-19

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 88.50  E-value: 1.57e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 136 PSPRTFHtSSAAIGNQLYVFGGgERGAQPVQDTKLHVFDANTLTWSQPETLGNPPS-PRHGHVMVAAGTKLFIHGGLAGD 214
Cdd:PLN02153   20 PGPRCSH-GIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRDEK 97

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034663467 215 RFYDDLHCIDISDMKWQ---KLNPTGAaPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQH 279
Cdd:PLN02153   98 REFSDFYSYDTVKNEWTfltKLDEEGG-PEARTFHSMASDENHVYVFGGVSKGGLMKTPERFRTIEAY 164
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
125-283 3.00e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 86.75  E-value: 3.00e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 125 TWTTpevTSPPPSPRTfHTSSAAIGNQLYVFGGGERGAQPvqdTKLHVFDANTLTWSQpetLGNPP-SPRHGHVMVAAGT 203
Cdd:COG3055     2 TWSS---LPDLPTPRS-EAAAALLDGKVYVAGGLSGGSAS---NSFEVYDPATNTWSE---LAPLPgPPRHHAAAVAQDG 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 204 KLFIHGGLAGD----RFYDDLHCIDISDMKWQKLNPtgaAPAGCAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQH 279
Cdd:COG3055    72 KLYVFGGFTGAnpssTPLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGT 148


                  ....
gi 1034663467 280 WTLL 283
Cdd:COG3055   149 WTQL 152
PLN02193 PLN02193
nitrile-specifier protein
 9-283 1.03e-18

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 87.32  E-value: 1.03e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467   9 PGDKPRKATWYTLTVPGDSPCARVGHScsyLPPVGNakrgKVFIVGGA-NPNRSFSD-VHTMDLGKHQWDLDTCKGLLPr 86
Cdd:PLN02193  144 PSTPKLLGKWIKVEQKGEGPGLRCSHG---IAQVGN----KIYSFGGEfTPNQPIDKhLYVFDLETRTWSISPATGDVP- 215

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  87 yeHASFIPSC---TPDRIWVFGGANQSGNRNCLQVLNPETRTWTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAq 163
Cdd:PLN02193  216 --HLSCLGVRmvsIGSTLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVEEGPTPRSFH-SMAADEENVYVFGGVSATA- 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 164 pvqdtKLHVFDANTL---TWSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFyDDLHCIDISDMKWQKLNPTGAAP 240
Cdd:PLN02193  292 -----RLKTLDSYNIvdkKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNGCEV-DDVHYYDPVQDKWTQVETFGVRP 365

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034663467 241 AGCAAHSAVAMGKHVYIFGG---------MTPAGALDTMYQYHTEEQHWTLL 283
Cdd:PLN02193  366 SERSVFASAAVGKHIVIFGGeiamdplahVGPGQLTDGTFALDTETLQWERL 417
PLN02153 PLN02153
epithiospecifier protein
 25-260 1.89e-14

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 73.48  E-value: 1.89e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  25 GDSPCARVGHScsyLPPVGNakrgKVFIVGGA-NPNRSF-SDVHTMDLGKHQWDLDTCKGLLPRYEHASFIPSCTPDRIW 102
Cdd:PLN02153   17 GKGPGPRCSHG---IAVVGD----KLYSFGGElKPNEHIdKDLYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLY 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 103 VFGGANQSGNRNCLQVLNPETRTWT--TPEVTSPPPSPRTFHtSSAAIGNQLYVFGGGERGAQPVQDTKLHVFDANTLT- 179
Cdd:PLN02153   90 IFGGRDEKREFSDFYSYDTVKNEWTflTKLDEEGGPEARTFH-SMASDENHVYVFGGVSKGGLMKTPERFRTIEAYNIAd 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 180 --WSQPETLGNPPSPRHGHVMVAAGTKLFIHGGLA------GDRFYDD--LHCIDISDMKWQKLNPTGAAPAGCAAHSAV 249
Cdd:PLN02153  169 gkWVQLPDPGENFEKRGGAGFAVVQGKIWVVYGFAtsilpgGKSDYESnaVQFFDPASGKWTEVETTGAKPSARSVFAHA 248

                         250
                  ....*....|.
gi 1034663467 250 AMGKHVYIFGG 260
Cdd:PLN02153  249 VVGKYIIIFGG 259
PLN02153 PLN02153
epithiospecifier protein
 187-298 6.94e-11

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 62.70  E-value: 6.94e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 187 GNPPSPRHGHVMVAAGTKLFIHGG-LAGDRFYD-DLHCIDISDMKWQKLNPTGAAPA-GCAAHSAVAMGKHVYIFGGMTP 263
Cdd:PLN02153   17 GKGPGPRCSHGIAVVGDKLYSFGGeLKPNEHIDkDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVAVGTKLYIFGGRDE 96

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1034663467 264 AGALDTMYQYHTEEQHWTLL-KFDTL-LPPGRLDHSM 298
Cdd:PLN02153   97 KREFSDFYSYDTVKNEWTFLtKLDEEgGPEARTFHSM 133
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
179-298 1.26e-10

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 61.33  E-value: 1.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 179 TWSqpeTLGNPPSPRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNPTGAAPAGCAAhsAVAMGKHVYIF 258
Cdd:COG3055     2 TWS---SLPDLPTPRSEAAAALLDGKVYVAGGLSGGSASNSFEVYDPATNTWSELAPLPGPPRHHAA--AVAQDGKLYVF 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034663467 259 GGMTPA----GALDTMYQYHTEEQHWTLLkfdTLLPPGRLDHSM 298
Cdd:COG3055    77 GGFTGAnpssTPLNDVYVYDPATNTWTKL---APMPTPRGGATA 117
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
13-174 5.49e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 56.70  E-value: 5.49e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  13 PRKATWytlTVPGDSPCARVGHSCSYLPpvgnakRGKVFIVGGAN---PNRSFSDVHTMdlgkhqwdldtckgLLPRYEH 89
Cdd:COG3055   144 PATGTW---TQLAPLPTPRDHLAAAVLP------DGKILVIGGRNgsgFSNTWTTLAPL--------------PTARAGH 200

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  90 ASFIPSctpDRIWVFGGanQSGNRNCLQVLNPETRTWTTpevTSPPPSPRTFHTSsAAIGNQLYVFGGG-ERGAQPVQDT 168
Cdd:COG3055   201 AAAVLG---GKILVFGG--ESGFSDEVEAYDPATNTWTA---LGELPTPRHGHAA-VLTDGKVYVIGGEtKPGVRTPLVT 271


                  ....*.
gi 1034663467 169 KLHVFD 174
Cdd:COG3055   272 SAEVYD 277
PRK14131 PRK14131
N-acetylneuraminate epimerase;
145-260 6.41e-09

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 56.95  E-value: 6.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 145 SAAIGNQLYVfGGGERGaqpvqdTKLHVFDANTLT--WSQPETLgnPPSPRHGHVMVAAGTKLFIHGGL------AGDRF 216
Cdd:PRK14131   34 GAIDNNTVYV-GLGSAG------TSWYKLDLNAPSkgWTKIAAF--PGGPREQAVAAFIDGKLYVFGGIgktnseGSPQV 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034663467 217 YDDLHCIDISDMKWQKLNPTgaAPAGCAAHSAVAM-GKHVYIFGG 260
Cdd:PRK14131  105 FDDVYKYDPKTNSWQKLDTR--SPVGLAGHVAVSLhNGKAYITGG 147
PRK14131 PRK14131
N-acetylneuraminate epimerase;
41-272 1.02e-07

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 53.10  E-value: 1.02e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  41 PVGNAKRGKVFIVGG------ANPNRSFSDVHTMDLGKHQWD-LDTC--KGLLpryEHASFIPSctPDRIWVFGGANQS- 110
Cdd:PRK14131   78 AVAAFIDGKLYVFGGigktnsEGSPQVFDDVYKYDPKTNSWQkLDTRspVGLA---GHVAVSLH--NGKAYITGGVNKNi 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 111 ----------------------------------GNRNCLqVLNPETRTWTTPEVTsppPSPRTFHTSSAAIGNQLYVFG 156
Cdd:PRK14131  153 fdgyfedlaaagkdktpkdkindayfdkkpedyfFNKEVL-SYDPSTNQWKNAGES---PFLGTAGSAVVIKGNKLWLIN 228

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 157 G----GERGAQpvqdTKLHVFDANTLTWSQPETLgnPPSPR---------------HGHVMVAAGT------------KL 205
Cdd:PRK14131  229 GeikpGLRTDA----VKQGKFTGNNLKWQKLPDL--PPAPGgssqegvagafagysNGVLLVAGGAnfpgarenyqngKL 302

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034663467 206 FIHGGLAgDRFYDDLHCIDisDMKWQKLnptGAAPAGCAAHSAVAMGKHVYIFGGMTPAG-ALDTMYQ 272
Cdd:PRK14131  303 YAHEGLK-KSWSDEIYALV--NGKWQKV---GELPQGLAYGVSVSWNNGVLLIGGETAGGkAVSDVTL 364
PLN02153 PLN02153
epithiospecifier protein
 17-221 5.63e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 50.76  E-value: 5.63e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  17 TWYTLTVPGDSPcaRVGHSCSYLPPVGNakrgKVFIVGGANPNRSFSDVHTMDLGKHQW----DLDTCKGLLPRYEHASf 92
Cdd:PLN02153   61 TWSIAPANGDVP--RISCLGVRMVAVGT----KLYIFGGRDEKREFSDFYSYDTVKNEWtfltKLDEEGGPEARTFHSM- 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  93 ipSCTPDRIWVFGGANQSG------------------------------------------------------------- 111
Cdd:PLN02153  134 --ASDENHVYVFGGVSKGGlmktperfrtieayniadgkwvqlpdpgenfekrggagfavvqgkiwvvygfatsilpggk 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 112 ---NRNCLQVLNPETRTWTTPEVTSPPPSPRTFHtSSAAIGNQLYVFGG-------GERGAQPVQDTKlHVFDANTLTWS 181
Cdd:PLN02153  212 sdyESNAVQFFDPASGKWTEVETTGAKPSARSVF-AHAVVGKYIIIFGGevwpdlkGHLGPGTLSNEG-YALDTETLVWE 289

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1034663467 182 QPETLGNPPSPRHGHVMVAA---GTK-LFIHGG-LAGDRFYDDLH 221
Cdd:PLN02153  290 KLGECGEPAMPRGWTAYTTAtvyGKNgLLMHGGkLPTNERTDDLY 334
PLN02153 PLN02153
epithiospecifier protein
 81-293 1.20e-06

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 49.98  E-value: 1.20e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  81 KGLLPRYEHASfipSCTPDRIWVFGG---ANQSGNRNcLQVLNPETRTWTTPEVTSPPPSPRTFHTSSAAIGNQLYVFGG 157
Cdd:PLN02153   18 KGPGPRCSHGI---AVVGDKLYSFGGelkPNEHIDKD-LYVFDFNTHTWSIAPANGDVPRISCLGVRMVAVGTKLYIFGG 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 158 GErgaQPVQDTKLHVFDANTLTW---SQPETLGNPPSpRHGHVMVAAGTKLFIHGGLAG-------DRFyDDLHCIDISD 227
Cdd:PLN02153   94 RD---EKREFSDFYSYDTVKNEWtflTKLDEEGGPEA-RTFHSMASDENHVYVFGGVSKgglmktpERF-RTIEAYNIAD 168

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034663467 228 MKWQKL-NPTGAAPAGCAAHSAVAMGKHVYIFGGMT---PAGALD----TMYQYHTEEQHWTLLKFDTLLPPGR 293
Cdd:PLN02153  169 GKWVQLpDPGENFEKRGGAGFAVVQGKIWVVYGFATsilPGGKSDyesnAVQFFDPASGKWTEVETTGAKPSAR 242
Kelch_3 pfam13415
Galactose oxidase, central domain;
149-201 1.26e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 44.97  E-value: 1.26e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034663467 149 GNQLYVFGGGERGAQPVqDTKLHVFDANTLTWsqpETLGNPPSPRHGHVMVAA 201
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTR-LNDLYVYDLDTNTW---TQIGDLPPPRSGHSATYI 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
99-147 3.30e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.82  E-value: 3.30e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034663467  99 DRIWVFGGANQSGNR--NCLQVLNPETRTWTTpevTSPPPSPRTFHTSSAA 147
Cdd:pfam13415   2 DKLYIFGGLGFDGQTrlNDLYVYDLDTNTWTQ---IGDLPPPRSGHSATYI 49
Kelch_6 pfam13964
Kelch motif;
138-193 8.24e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 42.71  E-value: 8.24e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034663467 138 PRTFHtSSAAIGNQLYVFGGGERGAQPVQdtKLHVFDANTLTWsqpETLGNPPSPR 193
Cdd:pfam13964   1 PRTFH-SVVSVGGYIYVFGGYTNASPALN--KLEVYNPLTKSW---EELPPLPTPR 50
PHA03098 PHA03098
kelch-like protein; Provisional
 41-230 1.46e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 46.68  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  41 PVGNAKRGKVFIVGGANPNRSFSDVHTMDLGKHQWDLDTcKGLLPRYEHASFIpscTPDRIWVFGGANQSG-NRNCLQVL 119
Cdd:PHA03098  336 PGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEP-PLIFPRYNPCVVN---VNNLIYVIGGISKNDeLLKTVECF 411

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 120 NPETRTWTTPEvtsppPSPRTFHTSSAAI-GNQLYVFGGGERGAQPVQDTKLHVFDANTLTWSQPETLGNppsPRHGHVM 198
Cdd:PHA03098  412 SLNTNKWSKGS-----PLPISHYGGCAIYhDGKIYVIGGISYIDNIKVYNIVESYNPVTNKWTELSSLNF---PRINASL 483

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1034663467 199 VAAGTKLFIHGGLAGDRFYDDLHCIDISDMKW 230
Cdd:PHA03098  484 CIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 243-283 2.53e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.06  E-value: 2.53e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034663467 243 CAAHSAVAMGKHVYIFGGMTPAGALDTMYQYHTEEQHWTLL 283
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKL 42
PHA03098 PHA03098
kelch-like protein; Provisional
 99-301 1.36e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 1.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467  99 DRIWVFGGANQSGNR-NCLQVLNPETRTWTT-PEVTSPPPSPrtfhtSSAAIGNQLYVFGGgERGAQPVQDTKLHVFDAN 176
Cdd:PHA03098  295 NVIYFIGGMNKNNLSvNSVVSYDTKTKSWNKvPELIYPRKNP-----GVTVFNNRIYVIGG-IYNSISLNTVESWKPGES 368

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034663467 177 TltWSQPETLgnpPSPRHGHVMVAAGTKLFIHGGLA-GDRFYDDLHCIDISDMKWQKLNPTgaaPAGCAAHSAVAMGKHV 255
Cdd:PHA03098  369 K--WREEPPL---IFPRYNPCVVNVNNLIYVIGGISkNDELLKTVECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKI 440

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1034663467 256 YIFGGMTPA---GALDTMYQYHTEEQHWTLLKfdTLLPPgRLDHSMCII 301
Cdd:PHA03098  441 YVIGGISYIdniKVYNIVESYNPVTNKWTELS--SLNFP-RINASLCIF 486
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 192-235 1.55e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 38.75  E-value: 1.55e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034663467 192 PRHGHVMVAAGTKLFIHGGLAGDRFYDDLHCIDISDMKWQKLNP 235
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPS 44
Kelch_4 pfam13418
Galactose oxidase, central domain;
138-191 1.67e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 38.75  E-value: 1.67e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1034663467 138 PRTFHTSSAAIGNQLYVFGGgeRGAQPVQDTKLHVFDANTLTWSQpetLGNPPS 191
Cdd:pfam13418   1 PRAYHTSTSIPDDTIYLFGG--EGEDGTLLSDLWVFDLSTNEWTR---LGSLPS 49
Kelch_4 pfam13418
Galactose oxidase, central domain;
85-136 3.46e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.98  E-value: 3.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034663467  85 PRYEHASFipSCTPDRIWVFGGANQSGNR-NCLQVLNPETRTWTTpeVTSPPP 136
Cdd:pfam13418   1 PRAYHTST--SIPDDTIYLFGGEGEDGTLlSDLWVFDLSTNEWTR--LGSLPS 49
Kelch_6 pfam13964
Kelch motif;
85-139 4.46e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 4.46e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034663467  85 PRYEHASFIPSctpDRIWVFGGANQSGNR-NCLQVLNPETRTWttpEVTSPPPSPR 139
Cdd:pfam13964   1 PRTFHSVVSVG---GYIYVFGGYTNASPAlNKLEVYNPLTKSW---EELPPLPTPR 50
Kelch_4 pfam13418
Galactose oxidase, central domain;
192-233 5.50e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 5.50e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034663467 192 PRHGHVMVA-AGTKLFIHGGLAGD-RFYDDLHCIDISDMKWQKL 233
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEGEDgTLLSDLWVFDLSTNEWTRL 44
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 190-221 5.89e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 37.16  E-value: 5.89e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1034663467 190 PSPRHGHVMVAAGTKLFIHGGLAGDR--FYDDLH 221
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEgqPSDDVY 34
PLN02772 PLN02772
guanylate kinase
 144-214 8.79e-04

guanylate kinase


Pssm-ID: 215414 [Multi-domain]  Cd Length: 398  Bit Score: 40.98  E-value: 8.79e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034663467 144 SSAAIGNQLYVFGGGERGAQPVQDTKLhvFDANTLTWSQPETLGNPPSPRHGH--VMVAAGTKLFIHGGLAGD 214
Cdd:PLN02772   29 TSVTIGDKTYVIGGNHEGNTLSIGVQI--LDKITNNWVSPIVLGTGPKPCKGYsaVVLNKDRILVIKKGSAPD 99
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 240-276 9.97e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 33.69  E-value: 9.97e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1034663467 240 PAGCAAHSAVAMGKHVYIFGGMTPAG--ALDTMYQYHTE 276
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEgqPSDDVYVLSLP 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH