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Concise Results
Standard Results
Full Results
insulin-degrading enzyme isoform X3 [Homo sapiens]
Protein Classification
M16 family metallopeptidase ( domain architecture ID 1000463 )
M16 family metallopeptidase is a zinc-dependent protease, similar to insulin-degrading enzyme (insulinase)
List of domain hits
Name
Accession
Description
Interval
E-value
Ptr super family
cl34066 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
13-965
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
COG1025 :Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 925.79
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 13 I T KSP E D K R E YR GLE L A NG I KVLL I SDP TT DKS S AAL D V HI GS LS DP PNIA GL S HF C EHMLFLGTKKYP KEN EY SQ F L S E 92
Cdd:COG1025 35 I I KSP N D P R Q YR AIT L D NG L KVLL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L EHMLFLGTKKYP EPG EY QE F I S K 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 93 H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ESCK DRE V NAV DS E HEKNVMN D AW R LF Q LE K A T G NP K H 172
Cdd:COG1025 115 H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E YTLKRSD D GR R IY Q VH K E T L NP A H 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 173 PFS K F GT GN KY TL ETR P NQE gid V R Q ELL K F HSA YYS S NLM AVCVLGRE SLD D L TN L VVKL F SEVE N K N VPL P EFPEHPF 252
Cdd:COG1025 195 PFS R F SV GN LE TL SDK P GSK --- L R D ELL A F YQR YYS A NLM KLVLYSNQ SLD E L EK L ARQT F GAIP N R N LSV P PITVPLY 271
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 253 QE E H L KQLYK IVP I K DI R N L YVT FPIP DL Q K YY K S N P GH Y LGH L I G H EG P GSLL SE LK SK G WVNT L VG G QKEGA R G F MF F 332
Cdd:COG1025 272 TP E Q L GIIIH IVP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW LK KQ G LAES L SA G GGISG R N F GD F 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 333 I I N V D LT EE GL L H VED II LHM F Q YI QKL R AE G P QEW V F Q E CKD L NAV AFRF KD K E RP RG Y T S KIAGILHY YP L E E VL T A E 412
Cdd:COG1025 352 S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP MD Y V S WLSDNMLR YP V E D VL D A D 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 413 YL LEE F R P DL I EMV L DK L R PEN V R VAIV S K sf EGK TD R T EE WY G T Q Y KQEA I PD E VIK KWQ N A DL N GKFK LP TK N EF IP T 492
Cdd:COG1025 432 YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQ E QLA KWQ Q A SQ N PALS LP EL N PY IP D 509
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 493 N F EILP L E KE AT p Y P A L IK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHCNMAY L YLE LL K D S LNE YA Y A A EL 572
Cdd:COG1025 510 D F SLIK L D KE SA - K P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQVLTR L LDY LL N D A LNE LS Y Q A SV 588
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 573 AGLSY D L QNTIY G MY LS VK G YND KQP I LL KKIIEKM A T FE ID E K RF EII K EAYM R S L N N FRAEQ P HQHAMYY L RL L MTEV 652
Cdd:COG1025 589 AGLSY S L YAHQG G LT LS AS G FTQ KQP K LL EALLDQL A S FE PT E E RF AQA K SQLL R Q L D N AEKAK P YSQLFSP L SR L LQPP 668
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 653 AWTKD EL KE AL DDV TL PR L K AF IP QLL SR LH I E A L LH GN ITKQA A LGIMQMVEDT L IEHAHTKPLLP sqlvry RE V Q L PD 732
Cdd:COG1025 669 YFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L APNGTGEEPRR ------ QV V D L DK 742
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 733 R G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLGY I V FS G PRRANGIQ GL R F II QS - 811
Cdd:COG1025 743 S G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLGY V V GA G YMPLGRQP GL G F YV QS p 821
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 812 EKP P H YL ES R VEA FL ITM E KSIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W GE I ISQQYN FD RDNTEV A YL K T LT 891
Cdd:COG1025 822 VAS P A YL LE R IDD FL KQF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W VD I GNGDFE FD TREKLI A AV K K LT 901
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034568067 892 KE D I I K F YKE ml AV D AP RRHKVSVHVLAR emdscpvvgefpcqndi NL S Q A PA L PQPEV I QNMTE F KRG LP LFP 965
Cdd:COG1025 902 RA D L I D F FQQ -- AV I AP QGLRLLSQSQGT ----------------- KH S K A DE L KGWKT I TDISA F QKT LP VKE 956
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
13-965
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 925.79
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 13 I T KSP E D K R E YR GLE L A NG I KVLL I SDP TT DKS S AAL D V HI GS LS DP PNIA GL S HF C EHMLFLGTKKYP KEN EY SQ F L S E 92
Cdd:COG1025 35 I I KSP N D P R Q YR AIT L D NG L KVLL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L EHMLFLGTKKYP EPG EY QE F I S K 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 93 H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ESCK DRE V NAV DS E HEKNVMN D AW R LF Q LE K A T G NP K H 172
Cdd:COG1025 115 H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E YTLKRSD D GR R IY Q VH K E T L NP A H 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 173 PFS K F GT GN KY TL ETR P NQE gid V R Q ELL K F HSA YYS S NLM AVCVLGRE SLD D L TN L VVKL F SEVE N K N VPL P EFPEHPF 252
Cdd:COG1025 195 PFS R F SV GN LE TL SDK P GSK --- L R D ELL A F YQR YYS A NLM KLVLYSNQ SLD E L EK L ARQT F GAIP N R N LSV P PITVPLY 271
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 253 QE E H L KQLYK IVP I K DI R N L YVT FPIP DL Q K YY K S N P GH Y LGH L I G H EG P GSLL SE LK SK G WVNT L VG G QKEGA R G F MF F 332
Cdd:COG1025 272 TP E Q L GIIIH IVP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW LK KQ G LAES L SA G GGISG R N F GD F 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 333 I I N V D LT EE GL L H VED II LHM F Q YI QKL R AE G P QEW V F Q E CKD L NAV AFRF KD K E RP RG Y T S KIAGILHY YP L E E VL T A E 412
Cdd:COG1025 352 S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP MD Y V S WLSDNMLR YP V E D VL D A D 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 413 YL LEE F R P DL I EMV L DK L R PEN V R VAIV S K sf EGK TD R T EE WY G T Q Y KQEA I PD E VIK KWQ N A DL N GKFK LP TK N EF IP T 492
Cdd:COG1025 432 YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQ E QLA KWQ Q A SQ N PALS LP EL N PY IP D 509
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 493 N F EILP L E KE AT p Y P A L IK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHCNMAY L YLE LL K D S LNE YA Y A A EL 572
Cdd:COG1025 510 D F SLIK L D KE SA - K P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQVLTR L LDY LL N D A LNE LS Y Q A SV 588
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 573 AGLSY D L QNTIY G MY LS VK G YND KQP I LL KKIIEKM A T FE ID E K RF EII K EAYM R S L N N FRAEQ P HQHAMYY L RL L MTEV 652
Cdd:COG1025 589 AGLSY S L YAHQG G LT LS AS G FTQ KQP K LL EALLDQL A S FE PT E E RF AQA K SQLL R Q L D N AEKAK P YSQLFSP L SR L LQPP 668
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 653 AWTKD EL KE AL DDV TL PR L K AF IP QLL SR LH I E A L LH GN ITKQA A LGIMQMVEDT L IEHAHTKPLLP sqlvry RE V Q L PD 732
Cdd:COG1025 669 YFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L APNGTGEEPRR ------ QV V D L DK 742
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 733 R G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLGY I V FS G PRRANGIQ GL R F II QS - 811
Cdd:COG1025 743 S G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLGY V V GA G YMPLGRQP GL G F YV QS p 821
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 812 EKP P H YL ES R VEA FL ITM E KSIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W GE I ISQQYN FD RDNTEV A YL K T LT 891
Cdd:COG1025 822 VAS P A YL LE R IDD FL KQF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W VD I GNGDFE FD TREKLI A AV K K LT 901
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034568067 892 KE D I I K F YKE ml AV D AP RRHKVSVHVLAR emdscpvvgefpcqndi NL S Q A PA L PQPEV I QNMTE F KRG LP LFP 965
Cdd:COG1025 902 RA D L I D F FQQ -- AV I AP QGLRLLSQSQGT ----------------- KH S K A DE L KGWKT I TDISA F QKT LP VKE 956
PRK15101
PRK15101 protease3; Provisional
13-909
6.09e-150
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 469.07
E-value: 6.09e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 13 I T KS PE D K R E Y RGLE L A NG IK VLL I SDP TTD KS S AAL DVHI GSL S DP PNIA GL S H FC EHM LFL G T KKYP KENEYSQ FL SE 92
Cdd:PRK15101 34 I R KS EK D P R Q Y QAIR L D NG MT VLL V SDP QAV KS L AAL ALPV GSL E DP DAQQ GL A H YL EHM VLM G S KKYP QPDSLAE FL KK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 93 H A GS S NA F T SGEH T NY Y FD V SHEH L EG A L DR F A QFFLC PL F D ESCK DRE V NAV DS E HEKNVMN D AW R LF Q LEKA T G NP K H 172
Cdd:PRK15101 114 H G GS H NA S T ASYR T AF Y LE V ENDA L PP A V DR L A DAIAE PL L D PKNA DRE R NAV NA E LTMARSR D GM R MA Q VSAE T I NP A H 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 173 P F S K F GT GN KY TL ETR P NQE gid VRQE L LK F HSA YYS S NLM AVCVLGRES L DD L TN L VVKL F SE V E NKN VPL PE FPEHPF 252
Cdd:PRK15101 194 P G S R F SG GN LE TL SDK P GSK --- LQDA L VD F YQR YYS A NLM KAVIYSNQP L PE L AK L AADT F GR V P NKN ASV PE ITVPVV 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 253 QEEHLKQLYKI VP IKDIRN L Y V T F P I PDLQKYYK S NPGH Y LGH LIG HEG PG S L LSE L KSK G WVNTLVG G QK --- EGAR G F 329
Cdd:PRK15101 271 TDAQKGIIIHY VP AQPRKV L R V E F R I DNNSAKFR S KTDE Y ISY LIG NRS PG T L SDW L QKQ G LAEGISA G AD pmv DRNS G V 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 330 mf F I I N V D LT EE GL LHVEDIILHM F Q Y IQK LR AE G PQEWV F Q E CKDLNAVA FR FKDKE R PRG Y TSKI A GILHYY P L E EV L 409
Cdd:PRK15101 351 -- F A I S V S LT DK GL AQRDQVVAAI F S Y LNL LR EK G IDKSY F D E LAHVLDLD FR YPSIT R DMD Y IEWL A DTMLRV P V E HT L 428
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 410 T A E Y LLEEFR P DL I EMV L DKLR P E N V R VAIV S K sf EGKTDR T EEWYGTQ Y KQEA I PDEVIKK WQ NADL N GKFK LP TK N EF 489
Cdd:PRK15101 429 D A P Y IADRYD P KA I KAR L AEMT P Q N A R IWYI S P -- QEPHNK T AYFVDAP Y QVDK I SEQTFAD WQ QKAQ N IALS LP EL N PY 506
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 490 IP TN F EILPLE K EAT p Y P A LI K D T ------ A M SKLW F KQD dkffl PKA CLNFEFFS P F A YVDPLHCNMAY L -- YL EL L kd 561
Cdd:PRK15101 507 IP DD F SLIKAD K AYK - H P E LI V D E pglrvv Y M PSQY F ADE ----- PKA DISLVLRN P K A MDSARNQVLFA L nd YL AG L -- 578
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 562 S L NEYAYA A ELA G L S YDL q N TIY G MYLSVK GY NDKQ P I LL KKII E KMAT F EID E KRFEII K EA Y MRS L NNFRAEQPHQH A 641
Cdd:PRK15101 579 A L DQLSNQ A SVG G I S FST - N ANN G LMVNAN GY TQRL P Q LL QALL E GYFS F TPT E EQLAQA K SW Y REQ L DSAEKGKAYEQ A 657
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 642 MYYLRL L MTEVAWTK DE LKEA L DDV TL PRLK A FIPQ LLS RLHI E A L LH GN I T KQAA lgimqmve D TL IEHAHTK - PLLPS 720
Cdd:PRK15101 658 IMPAQM L SQVPYFER DE RRKL L PSI TL KDVL A YRDA LLS GATP E F L VV GN L T EEQV -------- T TL ARDVQKQ l GADGT 729
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 721 QLV R YRE V QLPDRGWFVYQQRNEVHNNCGIEI Y YQ T --- DM QS TSENMF L E lfc QII SEPCF N T LRT K EQLGY I VF SG P R 797
Cdd:PRK15101 730 EWW R GKD V VVDKKQSVNFEKAGSSTDSALAAV Y VP T gyd EY QS SAYSSL L G --- QII QPWFY N Q LRT E EQLGY A VF AF P M 806
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 798 RANGIQ G LR F II QS - E K P P H YL ES R VE AF LITM E KSIED M TE E A F QKHI QAL AIRR L DK P KK L SA E CAKYWGEIISQQYN 876
Cdd:PRK15101 807 SVGRQW G MG F LL QS n D K Q P A YL WQ R YQ AF FPQA E AKLRA M KP E E F AQYQ QAL INQL L QA P QT L GE E ASRLSKDFDRGNMR 886
890 900 910
....*....|....*....|....*....|...
gi 1034568067 877 FD RDNTEV A YL K T LT KEDIIK F YKE ml AV DA P R 909
Cdd:PRK15101 887 FD SRDKII A QI K L LT PQKLAD F FHQ -- AV IE P Q 917
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
381-662
2.33e-134
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 405.03
E-value: 2.33e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 381 FRF KD K ER P RG Y T S KI A GILHY YP L E EV L TAE YLL E E FR P D LI EMV LD K L R PEN V R VAI VSK S FEG K TD RT E E WYGT Q Y K 460
Cdd:pfam16187 1 FRF QE K SP P SD Y V S SL A SNMQP YP P E DI L SGD YLL R E YD P E LI QEL LD Y L T PEN A R ITL VSK E FEG E TD QK E P WYGT E Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 461 Q E A IP D E VI KKW Q N - ADL N GKFK LP TK N E FIPT N F EILPL E - KE ATP YP A LI K DT AM S K LW F K Q DD K F FL PKA CLNFEFF 538
Cdd:pfam16187 81 V E P IP E E LL KKW K N a PEP N PELH LP EP N P FIPT D F DLKKK E v KE PAK YP V LI R DT PL S R LW Y K K DD T F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 539 SP F AY VD P LHCNMAY LY L ELLKDSLNEYAY A AELAGLSY D L QN T IY G MY LSV K GYNDK Q P I LL K KI I EK MAT FEID EK RF 618
Cdd:pfam16187 161 SP L AY SS P RNAVLTR LY V ELLKDSLNEYAY D AELAGLSY S L SA T ER G LT LSV S GYNDK L P V LL E KI L EK LRD FEID PD RF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1034568067 619 EIIKE AYM RS LN NF RA EQP H Q H A MY YL RL L MT E VA WT KD E LK EA 662
Cdd:pfam16187 241 EIIKE QLL RS YK NF AL EQP Y Q Q A FD YL LY L LE E RS WT PE E KL EA 284
Name
Accession
Description
Interval
E-value
Ptr
COG1025 Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, ...
13-965
0e+00
Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones];
Pssm-ID: 440648 [Multi-domain]
Cd Length: 956
Bit Score: 925.79
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 13 I T KSP E D K R E YR GLE L A NG I KVLL I SDP TT DKS S AAL D V HI GS LS DP PNIA GL S HF C EHMLFLGTKKYP KEN EY SQ F L S E 92
Cdd:COG1025 35 I I KSP N D P R Q YR AIT L D NG L KVLL V SDP QA DKS A AAL A V PV GS FD DP DDQQ GL A HF L EHMLFLGTKKYP EPG EY QE F I S K 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 93 H A GS S NA F T SG E H TNYYF D V SHEH LE G ALDRFA Q FF LC PLFD ESCK DRE V NAV DS E HEKNVMN D AW R LF Q LE K A T G NP K H 172
Cdd:COG1025 115 H G GS H NA S T AT E R TNYYF E V ENDA LE E ALDRFA D FF AA PLFD PEYV DRE R NAV NA E YTLKRSD D GR R IY Q VH K E T L NP A H 194
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 173 PFS K F GT GN KY TL ETR P NQE gid V R Q ELL K F HSA YYS S NLM AVCVLGRE SLD D L TN L VVKL F SEVE N K N VPL P EFPEHPF 252
Cdd:COG1025 195 PFS R F SV GN LE TL SDK P GSK --- L R D ELL A F YQR YYS A NLM KLVLYSNQ SLD E L EK L ARQT F GAIP N R N LSV P PITVPLY 271
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 253 QE E H L KQLYK IVP I K DI R N L YVT FPIP DL Q K YY K S N P GH Y LGH L I G H EG P GSLL SE LK SK G WVNT L VG G QKEGA R G F MF F 332
Cdd:COG1025 272 TP E Q L GIIIH IVP L K PR R Q L RLE FPIP NN Q A YY R S K P LT Y ISY L L G N EG E GSLL DW LK KQ G LAES L SA G GGISG R N F GD F 351
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 333 I I N V D LT EE GL L H VED II LHM F Q YI QKL R AE G P QEW V F Q E CKD L NAV AFRF KD K E RP RG Y T S KIAGILHY YP L E E VL T A E 412
Cdd:COG1025 352 S I S V S LT DK GL A H RDE II AAV F A YI ELI R QQ G I QEW Y F D E QAQ L LEL AFRF QE K T RP MD Y V S WLSDNMLR YP V E D VL D A D 431
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 413 YL LEE F R P DL I EMV L DK L R PEN V R VAIV S K sf EGK TD R T EE WY G T Q Y KQEA I PD E VIK KWQ N A DL N GKFK LP TK N EF IP T 492
Cdd:COG1025 432 YL MDG F D P AA I RAR L AQ L T PEN A R IWLI S P -- DVP TD K T AY WY D T P Y SVDP I TQ E QLA KWQ Q A SQ N PALS LP EL N PY IP D 509
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 493 N F EILP L E KE AT p Y P A L IK D TAMSK LW FKQ D DK F FL PKA CLNFEFFS P F A YVDPLHCNMAY L YLE LL K D S LNE YA Y A A EL 572
Cdd:COG1025 510 D F SLIK L D KE SA - K P E L LV D EPGLR LW YMP D QY F AE PKA DIYLSLRN P Q A VDSARNQVLTR L LDY LL N D A LNE LS Y Q A SV 588
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 573 AGLSY D L QNTIY G MY LS VK G YND KQP I LL KKIIEKM A T FE ID E K RF EII K EAYM R S L N N FRAEQ P HQHAMYY L RL L MTEV 652
Cdd:COG1025 589 AGLSY S L YAHQG G LT LS AS G FTQ KQP K LL EALLDQL A S FE PT E E RF AQA K SQLL R Q L D N AEKAK P YSQLFSP L SR L LQPP 668
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 653 AWTKD EL KE AL DDV TL PR L K AF IP QLL SR LH I E A L LH GN ITKQA A LGIMQMVEDT L IEHAHTKPLLP sqlvry RE V Q L PD 732
Cdd:COG1025 669 YFERE EL LA AL ESI TL QD L R AF RE QLL QQ LH L E M L VV GN LSEEQ A KQLADSLKKQ L APNGTGEEPRR ------ QV V D L DK 742
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 733 R G WFVYQQRNE v H NNCGIE IYYQ TDMQ S TSENMFLE L FC QIIS EPC FN T LRT K EQLGY I V FS G PRRANGIQ GL R F II QS - 811
Cdd:COG1025 743 S G SLNLEKACD - H TDSALL IYYQ SGYD S LASMALSS L LG QIIS PWF FN Q LRT E EQLGY V V GA G YMPLGRQP GL G F YV QS p 821
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 812 EKP P H YL ES R VEA FL ITM E KSIEDMT EE A F QKHI Q A L AIRR L DKPKK LS A E CAKY W GE I ISQQYN FD RDNTEV A YL K T LT 891
Cdd:COG1025 822 VAS P A YL LE R IDD FL KQF E ERLLALS EE E F AQYK Q G L INQL L EPDQN LS E E AQRL W VD I GNGDFE FD TREKLI A AV K K LT 901
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034568067 892 KE D I I K F YKE ml AV D AP RRHKVSVHVLAR emdscpvvgefpcqndi NL S Q A PA L PQPEV I QNMTE F KRG LP LFP 965
Cdd:COG1025 902 RA D L I D F FQQ -- AV I AP QGLRLLSQSQGT ----------------- KH S K A DE L KGWKT I TDISA F QKT LP VKE 956
PRK15101
PRK15101 protease3; Provisional
13-909
6.09e-150
protease3; Provisional
Pssm-ID: 185056 [Multi-domain]
Cd Length: 961
Bit Score: 469.07
E-value: 6.09e-150
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 13 I T KS PE D K R E Y RGLE L A NG IK VLL I SDP TTD KS S AAL DVHI GSL S DP PNIA GL S H FC EHM LFL G T KKYP KENEYSQ FL SE 92
Cdd:PRK15101 34 I R KS EK D P R Q Y QAIR L D NG MT VLL V SDP QAV KS L AAL ALPV GSL E DP DAQQ GL A H YL EHM VLM G S KKYP QPDSLAE FL KK 113
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 93 H A GS S NA F T SGEH T NY Y FD V SHEH L EG A L DR F A QFFLC PL F D ESCK DRE V NAV DS E HEKNVMN D AW R LF Q LEKA T G NP K H 172
Cdd:PRK15101 114 H G GS H NA S T ASYR T AF Y LE V ENDA L PP A V DR L A DAIAE PL L D PKNA DRE R NAV NA E LTMARSR D GM R MA Q VSAE T I NP A H 193
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 173 P F S K F GT GN KY TL ETR P NQE gid VRQE L LK F HSA YYS S NLM AVCVLGRES L DD L TN L VVKL F SE V E NKN VPL PE FPEHPF 252
Cdd:PRK15101 194 P G S R F SG GN LE TL SDK P GSK --- LQDA L VD F YQR YYS A NLM KAVIYSNQP L PE L AK L AADT F GR V P NKN ASV PE ITVPVV 270
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 253 QEEHLKQLYKI VP IKDIRN L Y V T F P I PDLQKYYK S NPGH Y LGH LIG HEG PG S L LSE L KSK G WVNTLVG G QK --- EGAR G F 329
Cdd:PRK15101 271 TDAQKGIIIHY VP AQPRKV L R V E F R I DNNSAKFR S KTDE Y ISY LIG NRS PG T L SDW L QKQ G LAEGISA G AD pmv DRNS G V 350
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 330 mf F I I N V D LT EE GL LHVEDIILHM F Q Y IQK LR AE G PQEWV F Q E CKDLNAVA FR FKDKE R PRG Y TSKI A GILHYY P L E EV L 409
Cdd:PRK15101 351 -- F A I S V S LT DK GL AQRDQVVAAI F S Y LNL LR EK G IDKSY F D E LAHVLDLD FR YPSIT R DMD Y IEWL A DTMLRV P V E HT L 428
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 410 T A E Y LLEEFR P DL I EMV L DKLR P E N V R VAIV S K sf EGKTDR T EEWYGTQ Y KQEA I PDEVIKK WQ NADL N GKFK LP TK N EF 489
Cdd:PRK15101 429 D A P Y IADRYD P KA I KAR L AEMT P Q N A R IWYI S P -- QEPHNK T AYFVDAP Y QVDK I SEQTFAD WQ QKAQ N IALS LP EL N PY 506
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 490 IP TN F EILPLE K EAT p Y P A LI K D T ------ A M SKLW F KQD dkffl PKA CLNFEFFS P F A YVDPLHCNMAY L -- YL EL L kd 561
Cdd:PRK15101 507 IP DD F SLIKAD K AYK - H P E LI V D E pglrvv Y M PSQY F ADE ----- PKA DISLVLRN P K A MDSARNQVLFA L nd YL AG L -- 578
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 562 S L NEYAYA A ELA G L S YDL q N TIY G MYLSVK GY NDKQ P I LL KKII E KMAT F EID E KRFEII K EA Y MRS L NNFRAEQPHQH A 641
Cdd:PRK15101 579 A L DQLSNQ A SVG G I S FST - N ANN G LMVNAN GY TQRL P Q LL QALL E GYFS F TPT E EQLAQA K SW Y REQ L DSAEKGKAYEQ A 657
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 642 MYYLRL L MTEVAWTK DE LKEA L DDV TL PRLK A FIPQ LLS RLHI E A L LH GN I T KQAA lgimqmve D TL IEHAHTK - PLLPS 720
Cdd:PRK15101 658 IMPAQM L SQVPYFER DE RRKL L PSI TL KDVL A YRDA LLS GATP E F L VV GN L T EEQV -------- T TL ARDVQKQ l GADGT 729
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 721 QLV R YRE V QLPDRGWFVYQQRNEVHNNCGIEI Y YQ T --- DM QS TSENMF L E lfc QII SEPCF N T LRT K EQLGY I VF SG P R 797
Cdd:PRK15101 730 EWW R GKD V VVDKKQSVNFEKAGSSTDSALAAV Y VP T gyd EY QS SAYSSL L G --- QII QPWFY N Q LRT E EQLGY A VF AF P M 806
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 798 RANGIQ G LR F II QS - E K P P H YL ES R VE AF LITM E KSIED M TE E A F QKHI QAL AIRR L DK P KK L SA E CAKYWGEIISQQYN 876
Cdd:PRK15101 807 SVGRQW G MG F LL QS n D K Q P A YL WQ R YQ AF FPQA E AKLRA M KP E E F AQYQ QAL INQL L QA P QT L GE E ASRLSKDFDRGNMR 886
890 900 910
....*....|....*....|....*....|...
gi 1034568067 877 FD RDNTEV A YL K T LT KEDIIK F YKE ml AV DA P R 909
Cdd:PRK15101 887 FD SRDKII A QI K L LT PQKLAD F FHQ -- AV IE P Q 917
Peptidase_M16_M
pfam16187 Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 ...
381-662
2.33e-134
Middle or third domain of peptidase_M16; Peptidase_M16_M is the third domain of peptidase_M16 in eukaryotes of the insulin-degrading-enzyme type. Insulin-degrading enzymes - insulysin - are zinc metallopeptidases that metabolize several bioactive peptides, including insulin and the amyloid-beta-peptide. The tertiary structure of insulin-degrading enzymes resembles a clamshell composed of four structurally similar domains arranged to enclose a large central chamber. Substrates must enter the chamber, and it is likely that a hinge-like conformational change allows substrate binding and product release. Triphosphates are found to dock between the inner surfaces of the non-catalytic domains three and four.
Pssm-ID: 465051 [Multi-domain]
Cd Length: 284
Bit Score: 405.03
E-value: 2.33e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 381 FRF KD K ER P RG Y T S KI A GILHY YP L E EV L TAE YLL E E FR P D LI EMV LD K L R PEN V R VAI VSK S FEG K TD RT E E WYGT Q Y K 460
Cdd:pfam16187 1 FRF QE K SP P SD Y V S SL A SNMQP YP P E DI L SGD YLL R E YD P E LI QEL LD Y L T PEN A R ITL VSK E FEG E TD QK E P WYGT E Y S 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 461 Q E A IP D E VI KKW Q N - ADL N GKFK LP TK N E FIPT N F EILPL E - KE ATP YP A LI K DT AM S K LW F K Q DD K F FL PKA CLNFEFF 538
Cdd:pfam16187 81 V E P IP E E LL KKW K N a PEP N PELH LP EP N P FIPT D F DLKKK E v KE PAK YP V LI R DT PL S R LW Y K K DD T F WV PKA NIYLSLR 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 539 SP F AY VD P LHCNMAY LY L ELLKDSLNEYAY A AELAGLSY D L QN T IY G MY LSV K GYNDK Q P I LL K KI I EK MAT FEID EK RF 618
Cdd:pfam16187 161 SP L AY SS P RNAVLTR LY V ELLKDSLNEYAY D AELAGLSY S L SA T ER G LT LSV S GYNDK L P V LL E KI L EK LRD FEID PD RF 240
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1034568067 619 EIIKE AYM RS LN NF RA EQP H Q H A MY YL RL L MT E VA WT KD E LK EA 662
Cdd:pfam16187 241 EIIKE QLL RS YK NF AL EQP Y Q Q A FD YL LY L LE E RS WT PE E KL EA 284
Peptidase_M16
pfam00675 Insulinase (Peptidase family M16);
33-171
1.76e-49
Insulinase (Peptidase family M16);
Pssm-ID: 425812 [Multi-domain]
Cd Length: 149
Bit Score: 171.72
E-value: 1.76e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 33 K V LLI SDP TT D K S SAA L DVHI GS LSD P P N IA GL S HF C EHM L F L GTKKYP k E NE YSQF L SEHA GS S NAFTS G E H T N YY FD V 112
Cdd:pfam00675 1 R V ASE SDP PA D T S TVG L WIDA GS RYE P D N NN GL A HF L EHM A F K GTKKYP - S NE LEEE L EKLG GS L NAFTS R E N T V YY AE V 79
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 113 SHEH L EG A L DR F A Q FF LC PLF D ES CKD R ------- EV N AVDSE HEK ---- N VMND A W R LFQ L EKATGN P K 171
Cdd:pfam00675 80 LNDD L PK A V DR L A D FF RN PLF T ES EIE R erlvvly EV E AVDSE PQL vvle N LHAA A Y R NTP L GRSLLG P G 149
PqqL
COG0612 Predicted Zn-dependent peptidase, M16 family [General function prediction only];
27-440
9.25e-46
Predicted Zn-dependent peptidase, M16 family [General function prediction only];
Pssm-ID: 440377 [Multi-domain]
Cd Length: 427
Bit Score: 170.49
E-value: 9.25e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 27 E L A NG IK V L L IS DP TTDKS S AA L D V HI GS LSD PP NIA GL S HF C EHMLF L GTKK YPK e N E YSQF L SEHA GS S NAFTS GEH T 106
Cdd:COG0612 19 T L P NG LR V I L VP DP EAPVV S VR L W V RV GS RDE PP GKT GL A HF L EHMLF K GTKK RSA - G E IAEE L EALG GS L NAFTS FDY T 97
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 107 N YY FD V SH E H LE G AL DRF A QFF L C P L FDE SCKD RE VNA V DS E HEKNVMNDAWRL F Q -- L EKAT G N pk HP FSKFGT G NKYT 184
Cdd:COG0612 98 V YY LS V LS E D LE L AL ELL A DRL L N P T FDE EELE RE RGV V LE E IRRYEDDPDGLA F E al L AALY G D -- HP YGRPII G TEES 175
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 185 L E T rpnqeg I D v R QE L LK F HSA YY SS N LMAVC V L G RESLDDLTN LV V K L F SEVENKNV P LPEF P EH P F Q E ehl KQLYKI V 264
Cdd:COG0612 176 I E A ------ I T - R ED L RA F YKR YY RP N NAVLV V V G DVDPEEVLA LV E K Y F GDLPAGPA P PRPD P AE P P Q T --- GPRRVV V 245
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 265 PIK D IR -- NLYVTF P I P DL qkyyk SN P GH Y ---- L GHLI G H e G PG S L L SEL -- KS KG WVNT l VG GQKEGA R GFMF F I I NV 336
Cdd:COG0612 246 DDP D AE qa HILLGY P G P AR ----- DD P DY Y aldv L NEIL G G - G FS S R L FQE lr EK KG LAYS - VG SSFSPY R DAGL F T I YA 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 337 DLTEEG L LHVEDI IL hmf QYIQK L RA EG PQ E WVFQEC K D -- L NAV A FRF kdk E RPR G YT S KIAGILH Y Y - P L EEVLTAEY 413
Cdd:COG0612 319 GTAPDK L EEALAA IL --- EELER L AK EG VT E EELERA K N ql L GSL A LSL --- E SNS G LA S QLGRYEL Y G g D L DYLEEYLE 392
410 420
....*....|....*....|....*...
gi 1034568067 414 LL E EFRPDLIEM V LD K - L R P E N VR V AI V 440
Cdd:COG0612 393 RI E AVTAEDVQA V AR K y L D P D N LV V VV V 420
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
197-375
2.33e-28
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 112.49
E-value: 2.33e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 197 R QE L LK F HSAY YS SNL M AVCVL G RESLDD L TN L VV K L F SEVENK nv P LPEFPEH P FQEEH LK QLYKI VP I KD IRN -- L YV 274
Cdd:pfam05193 4 R ED L RD F YKKH YS PDN M VLVIV G DVDHEE L LD L AE K Y F GDLPAS -- P KGKPRPP P LEPAK LK GREVV VP K KD EPQ ah L AL 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 275 T FP I P D L QKYYK S NPGHY L GH L I G HEGPGS L LS EL KS K - G WVNTLVGGQKEG a RGFMF F I I NVDLTE E gll H V EDI I LHM 353
Cdd:pfam05193 82 A FP G P P L NNDED S LALDV L NE L L G GGMSSR L FQ EL RE K e G LAYSVSSFNDSY - SDSGL F G I YATVDP E --- N V DEV I ELI 157
170 180
....*....|....*....|..
gi 1034568067 354 FQYIQ KL RA EG PQ E WVFQEC K D 375
Cdd:pfam05193 158 LEELE KL AQ EG VT E EELERA K N 179
Peptidase_M16_C
pfam05193 Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One ...
665-848
2.52e-14
Peptidase M16 inactive domain; Peptidase M16 consists of two structurally related domains. One is the active peptidase, whereas the other is inactive. The two domains hold the substrate like a clamp.
Pssm-ID: 428362 [Multi-domain]
Cd Length: 181
Bit Score: 72.04
E-value: 2.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 665 DV T LPR L KA F IPQLL S RLHIEALLH G NITKQAA L gim QMV E DTL ieh AHTKPLLPSQLVRYREVQLPDR G WF V YQQRNEV 744
Cdd:pfam05193 1 SL T RED L RD F YKKHY S PDNMVLVIV G DVDHEEL L --- DLA E KYF --- GDLPASPKGKPRPPPLEPAKLK G RE V VVPKKDE 74
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034568067 745 HNNC g IEIYYQT - DMQSTSENMF L ELFCQIISE ---- PC F NT LR T KE Q L G Y I V F S GPRRAN -- G IQ G LRFIIQS E K pphy 817
Cdd:pfam05193 75 PQAH - LALAFPG p PLNNDEDSLA L DVLNELLGG gmss RL F QE LR E KE G L A Y S V S S FNDSYS ds G LF G IYATVDP E N ---- 149
170 180 190
....*....|....*....|....*....|..
gi 1034568067 818 LESRV E AF L ITM EK SI - E DM TEE AFQKHIQA L 848
Cdd:pfam05193 150 VDEVI E LI L EEL EK LA q E GV TEE ELERAKNQ L 181
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
