cell cycle checkpoint control protein RAD9A isoform X5 [Homo sapiens]
Protein Classification
cell cycle checkpoint control RAD9 family protein( domain architecture ID 707160)
cell cycle checkpoint control RAD9 family protein, similar to RAD9 which is a component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair; may be partial
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| Rad9 super family | cl27191 | Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA ... |
3-73 | 4.74e-20 | ||
Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage. It contains a Bcl-2 homology domain 3 (BH3). The actual alignment was detected with superfamily member pfam04139: Pssm-ID: 427739 Cd Length: 253 Bit Score: 84.73 E-value: 4.74e-20
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| Name | Accession | Description | Interval | E-value | ||
| Rad9 | pfam04139 | Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA ... |
3-73 | 4.74e-20 | ||
Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage. It contains a Bcl-2 homology domain 3 (BH3). Pssm-ID: 427739 Cd Length: 253 Bit Score: 84.73 E-value: 4.74e-20
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| PCNA | cd00577 | Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These ... |
1-75 | 1.62e-03 | ||
Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the attachment of the polymerase. The trimeric PCNA ring is structurally similar to the dimeric ring formed by the DNA polymerase processivity factors in bacteria (beta subunit DNA polymerase III holoenzyme) and in bacteriophages (catalytic subunits in T4 and RB69). This structural correspondence further substantiates the mechanistic connection between eukaryotic and prokaryotic DNA replication that has been suggested on biochemical grounds. PCNA is also involved with proteins involved in cell cycle processes such as DNA repair and apoptosis. Many of these proteins contain a highly conserved motif known as the PIP-box (PCNA interacting protein box) which contains the sequence Qxx[LIM]xxF[FY]. Pssm-ID: 238322 [Multi-domain] Cd Length: 248 Bit Score: 37.99 E-value: 1.62e-03
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| Name | Accession | Description | Interval | E-value | ||
| Rad9 | pfam04139 | Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA ... |
3-73 | 4.74e-20 | ||
Rad9; Rad9 is required for transient cell-cycle arrests and transcriptional induction of DNA repair in response to DNA damage. It contains a Bcl-2 homology domain 3 (BH3). Pssm-ID: 427739 Cd Length: 253 Bit Score: 84.73 E-value: 4.74e-20
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| PCNA | cd00577 | Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These ... |
1-75 | 1.62e-03 | ||
Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the attachment of the polymerase. The trimeric PCNA ring is structurally similar to the dimeric ring formed by the DNA polymerase processivity factors in bacteria (beta subunit DNA polymerase III holoenzyme) and in bacteriophages (catalytic subunits in T4 and RB69). This structural correspondence further substantiates the mechanistic connection between eukaryotic and prokaryotic DNA replication that has been suggested on biochemical grounds. PCNA is also involved with proteins involved in cell cycle processes such as DNA repair and apoptosis. Many of these proteins contain a highly conserved motif known as the PIP-box (PCNA interacting protein box) which contains the sequence Qxx[LIM]xxF[FY]. Pssm-ID: 238322 [Multi-domain] Cd Length: 248 Bit Score: 37.99 E-value: 1.62e-03
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