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Conserved domains on  [gi|1034589704|ref|XP_016877404|]
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transmembrane protein 266 isoform X1 [Homo sapiens]

Protein Classification

ion transporter( domain architecture ID 1000054)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans super family cl37996
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 100-218 2.29e-07

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


The actual alignment was detected with superfamily member pfam00520:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 51.88  E-value: 2.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034589704 100 LNSFLVACVILVVILLTLELLidikllqFSSAFQFAGVIHWISLVILSVFFSETVLRIVVLGI-WDYIENKIEVFDGAVI 178
Cdd:pfam00520   4 FELFILLLILLNTIFLALETY-------FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034589704 179 ILSLAPMVASTVANGprspwdaiSLIIMLRIWRVKRVIDA 218
Cdd:pfam00520  77 LPSLISLVLSSVGSL--------SGLRVLRLLRLLRLLRL 108
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 100-218 2.29e-07

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 51.88  E-value: 2.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034589704 100 LNSFLVACVILVVILLTLELLidikllqFSSAFQFAGVIHWISLVILSVFFSETVLRIVVLGI-WDYIENKIEVFDGAVI 178
Cdd:pfam00520   4 FELFILLLILLNTIFLALETY-------FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034589704 179 ILSLAPMVASTVANGprspwdaiSLIIMLRIWRVKRVIDA 218
Cdd:pfam00520  77 LPSLISLVLSSVGSL--------SGLRVLRLLRLLRLLRL 108
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 100-218 2.29e-07

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 51.88  E-value: 2.29e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034589704 100 LNSFLVACVILVVILLTLELLidikllqFSSAFQFAGVIHWISLVILSVFFSETVLRIVVLGI-WDYIENKIEVFDGAVI 178
Cdd:pfam00520   4 FELFILLLILLNTIFLALETY-------FQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVV 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034589704 179 ILSLAPMVASTVANGprspwdaiSLIIMLRIWRVKRVIDA 218
Cdd:pfam00520  77 LPSLISLVLSSVGSL--------SGLRVLRLLRLLRLLRL 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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