folliculin isoform X3 [Homo sapiens]
Protein Classification
folliculin domain-containing protein( domain architecture ID 10966118)
folliculin domain-containing protein such as human folliculin that regulates transferrin receptor 1 transport and iron homeostasis
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| Folliculin_C | pfam16692 | Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine ... |
270-492 | 3.71e-116 | ||||
Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine nucleotide exchange factor (GEF) activity. : Pssm-ID: 465236 Cd Length: 226 Bit Score: 341.32 E-value: 3.71e-116
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| Folliculin super family | cl13199 | Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this ... |
106-191 | 5.35e-20 | ||||
Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex. Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, lung cysts, spontaneous pneumothorax, and renal cell carcinoma. Folliculin is the protein from the BHD4 gene and is found to have no significant homology to any other human proteins. It is expressed in most tissues. These same symptoms also occur in TSC or tuberous sclerosis complex, suggesting that the same pathway is involved, and it is likely that the target is the down-stream Tor2 - an essential gene. Folliculin appears to bind Tor2, and down-regulation of Tor2 activity leads to up-regulation of nitrogen responsive genes including membrane transporters and amino acid permeases. The actual alignment was detected with superfamily member pfam11704: Pssm-ID: 463323 Cd Length: 163 Bit Score: 86.87 E-value: 5.35e-20
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| Name | Accession | Description | Interval | E-value | ||||
| Folliculin_C | pfam16692 | Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine ... |
270-492 | 3.71e-116 | ||||
Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine nucleotide exchange factor (GEF) activity. Pssm-ID: 465236 Cd Length: 226 Bit Score: 341.32 E-value: 3.71e-116
|
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| Folliculin | pfam11704 | Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this ... |
106-191 | 5.35e-20 | ||||
Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex. Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, lung cysts, spontaneous pneumothorax, and renal cell carcinoma. Folliculin is the protein from the BHD4 gene and is found to have no significant homology to any other human proteins. It is expressed in most tissues. These same symptoms also occur in TSC or tuberous sclerosis complex, suggesting that the same pathway is involved, and it is likely that the target is the down-stream Tor2 - an essential gene. Folliculin appears to bind Tor2, and down-regulation of Tor2 activity leads to up-regulation of nitrogen responsive genes including membrane transporters and amino acid permeases. Pssm-ID: 463323 Cd Length: 163 Bit Score: 86.87 E-value: 5.35e-20
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| Name | Accession | Description | Interval | E-value | ||||
| Folliculin_C | pfam16692 | Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine ... |
270-492 | 3.71e-116 | ||||
Folliculin C-terminal domain; This is the C-terminal domain of folliculin. It has guanine nucleotide exchange factor (GEF) activity. Pssm-ID: 465236 Cd Length: 226 Bit Score: 341.32 E-value: 3.71e-116
|
||||||||
| Folliculin | pfam11704 | Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this ... |
106-191 | 5.35e-20 | ||||
Vesicle coat protein involved in Golgi to plasma membrane transport; In yeast cells this family functions in the regulated delivery of Gap1p (a general amino acid permease) to the cell surface, perhaps as a component of a post-Golgi secretory-vesicle coat complex. Birt-Hogg-Dube (BHD)4 syndrome is an autosomal dominant disorder characterized by hamartomas of skin follicles, lung cysts, spontaneous pneumothorax, and renal cell carcinoma. Folliculin is the protein from the BHD4 gene and is found to have no significant homology to any other human proteins. It is expressed in most tissues. These same symptoms also occur in TSC or tuberous sclerosis complex, suggesting that the same pathway is involved, and it is likely that the target is the down-stream Tor2 - an essential gene. Folliculin appears to bind Tor2, and down-regulation of Tor2 activity leads to up-regulation of nitrogen responsive genes including membrane transporters and amino acid permeases. Pssm-ID: 463323 Cd Length: 163 Bit Score: 86.87 E-value: 5.35e-20
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| Blast search parameters | ||||
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