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Conserved domains on  [gi|1034598731|ref|XP_016879834|]
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protein spinster homolog 3 isoform X7 [Homo sapiens]

Protein Classification

spinster family MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085|GO:0006869
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1.49

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 16-223 2.75e-74

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 232.13  E-value: 2.75e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  16 WSFVWSTLGVTAMAFVTGALGFWAPKFLLEARVVhglqppcfQEPCSNPDSLIFGALTIMTGVIGVILGAEAARRYKKVI 95
Cdd:cd17328   207 PSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKT 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  96 PGAEPLICASSLLATAPCLYLALVLAPTTLLASYVFLGLGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVGHILGD 175
Cdd:cd17328   279 PRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGD 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1034598731 176 AGSPYLTGLISSVLRArRPDSYLQRFRSLQQSFLCCAFVIALGGGCFL 223
Cdd:cd17328   359 AGSPYLIGLISDLLRQ-NKDSPLAEAASLQYALLLCSFVLVLGGFFFL 405
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 16-223 2.75e-74

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 232.13  E-value: 2.75e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  16 WSFVWSTLGVTAMAFVTGALGFWAPKFLLEARVVhglqppcfQEPCSNPDSLIFGALTIMTGVIGVILGAEAARRYKKVI 95
Cdd:cd17328   207 PSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKT 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  96 PGAEPLICASSLLATAPCLYLALVLAPTTLLASYVFLGLGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVGHILGD 175
Cdd:cd17328   279 PRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGD 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1034598731 176 AGSPYLTGLISSVLRArRPDSYLQRFRSLQQSFLCCAFVIALGGGCFL 223
Cdd:cd17328   359 AGSPYLIGLISDLLRQ-NKDSPLAEAASLQYALLLCSFVLVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
16-231 2.11e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  16 WSFVWSTLGVTAMAFVTGALGFWAPKFLLEarvVHGLqppcfqepcSNPDSLIFGALTIMTGVIGVILGAEAARRYKKvi 95
Cdd:COG2271   180 LRFWLLALAYFLVYFALYGFLTWLPTYLVE---VRGL---------SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR-- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  96 pgAEPLICASSLLATAPCLYLALVLAPTTLLasYVFLGLGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVGhILGD 175
Cdd:COG2271   246 --RRKLVLAIGLLLAALALLLLALLPSPALA--IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG-FLGG 320

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034598731 176 AGSPYLTGLISSVLrarrpdsylqrfrSLQQSFLCCAFVIALGGGCFLLTALYLER 231
Cdd:COG2271   321 ALGPLLVGYLLDAT-------------GYQAAFLLLAALALLAALLALLLLRETRK 363
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 16-223 2.75e-74

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 232.13  E-value: 2.75e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  16 WSFVWSTLGVTAMAFVTGALGFWAPKFLLEARVVhglqppcfQEPCSNPDSLIFGALTIMTGVIGVILGAEAARRYKKVI 95
Cdd:cd17328   207 PSFILSTLGFTAVSFVTGALAFWAPTFFLRAFGV--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKT 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  96 PGAEPLICASSLLATAPCLYLALVLAPTTLLASYVFLGLGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVGHILGD 175
Cdd:cd17328   279 PRADPLVCAVGLLAAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHLLGD 358

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1034598731 176 AGSPYLTGLISSVLRArRPDSYLQRFRSLQQSFLCCAFVIALGGGCFL 223
Cdd:cd17328   359 AGSPYLIGLISDLLRQ-NKDSPLAEAASLQYALLLCSFVLVLGGFFFL 405
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
16-231 2.11e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 51.41  E-value: 2.11e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  16 WSFVWSTLGVTAMAFVTGALGFWAPKFLLEarvVHGLqppcfqepcSNPDSLIFGALTIMTGVIGVILGAEAARRYKKvi 95
Cdd:COG2271   180 LRFWLLALAYFLVYFALYGFLTWLPTYLVE---VRGL---------SLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGR-- 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  96 pgAEPLICASSLLATAPCLYLALVLAPTTLLasYVFLGLGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVGhILGD 175
Cdd:COG2271   246 --RRKLVLAIGLLLAALALLLLALLPSPALA--IALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFG-FLGG 320

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034598731 176 AGSPYLTGLISSVLrarrpdsylqrfrSLQQSFLCCAFVIALGGGCFLLTALYLER 231
Cdd:COG2271   321 ALGPLLVGYLLDAT-------------GYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 16-224 3.73e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 50.65  E-value: 3.73e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  16 WSFVWSTLGVTAMAFVTGALGFWAPKFLLEARVVHGLQppcfqepcsnpdsliFGALTIMTGVIGVILGAEAARRYKKVI 95
Cdd:cd17319   179 RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQ---------------VGLLAAIPFLAGAIGMILGGRLSDRLL 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  96 PGAEPLICASSLLATAPCLYLALVLapTTLLASYVFLGLGELLLSCNWAVVADILLSVVVPRCRGTAEALQITVGHILGd 175
Cdd:cd17319   244 RGARRLVIIIGLLLAAVGLLLAYLT--TSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGG- 320

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 1034598731 176 AGSPYLTGLIssvlrarrpdsyLQRFRSLQQSFLCCAFVIALGGGCFLL 224
Cdd:cd17319   321 FVAPLLIGYL------------VDATGSYTAAFLFLAAVALLAALLVLL 357
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 16-148 1.21e-03

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 39.93  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034598731  16 WSFVWSTLGVTAMAFVTGALGFWAPKFLLEArvvhglqppcFQEPCSNPdSLIFGALTIMTGVIGVILGAEAARRYKKVI 95
Cdd:cd17403   200 PTFMFLNLAGASEGMLLAGFATFLPKLIESQ----------FSLSASLA-ALLVGVVVVPGGILGTFLGGLIVKKLKLKC 268

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034598731  96 PGAEPLICASSLLATAPCLYLaLVLAPTTLLASyVFLGLGELLLSCNWAVVAD 148
Cdd:cd17403   269 KGILKFCIVCSIVAFLFSFIL-LIYCPNAPFAG-VTVPYGNSPLEGTSNLTST 319
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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