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Conserved domains on  [gi|1034599643|ref|XP_016880103|]
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keratin, type I cytoskeletal 15 isoform X2 [Homo sapiens]

Protein Classification

intermediate filament family protein( domain architecture ID 11981676)

intermediate filament (IF) family protein is a primordial component of the cytoskeleton and the nuclear envelope; such as type I keratins

CATH:  1.20.5.170
Gene Ontology:  GO:0005882
PubMed:  2183847|12596228|28101862

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
104-423 5.83e-140

Intermediate filament protein;


:

Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 402.76  E-value: 5.83e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 104 NEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPtSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDN 183
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGA-EPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 184 ARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppilqEMKEFSSQLA 263
Cdd:pfam00038  80 LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEE-------EVRELQAQVS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 264 -GQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIE 342
Cdd:pfam00038 153 dTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 343 LQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDA 422
Cdd:pfam00038 233 LQSLKKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEEC 312


                  .
gi 1034599643 423 K 423
Cdd:pfam00038 313 R 313
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
104-423 5.83e-140

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 402.76  E-value: 5.83e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 104 NEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPtSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDN 183
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGA-EPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 184 ARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppilqEMKEFSSQLA 263
Cdd:pfam00038  80 LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEE-------EVRELQAQVS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 264 -GQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIE 342
Cdd:pfam00038 153 dTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 343 LQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDA 422
Cdd:pfam00038 233 LQSLKKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEEC 312


                  .
gi 1034599643 423 K 423
Cdd:pfam00038 313 R 313
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 122-427 6.01e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.98  E-value: 6.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  122 KVRALEEANADLEVKIHDWYQKQTptSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELAL 201
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELE--ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAE 762

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  202 RQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHeewvppilqemKEFSSQLagqvnvemdaapgvDLTRV 281
Cdd:TIGR02168  763 IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL-----------DELRAEL--------------TLLNE 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  282 LAEMREQYEAMAEKNRRDVEAWFfsktEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETE 361
Cdd:TIGR02168  818 EAANLRERLESLERRIAATERRL----EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  362 CRYATQLQQIQGL---IGGLEAQLSELRCEMEA-QNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGI 427
Cdd:TIGR02168  894 SELEELSEELRELeskRSELRRELEELREKLAQlELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKI 963
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
148-432 5.66e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 5.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 148 SPECDYSQYFKTIEELRDKIMATTIDNSRVIlEI----DNARLAAddfrlKYENELA---LRQGVEADINGLRRVLDELT 220
Cdd:COG3206   108 DPLGEEASREAAIERLRKNLTVEPVKGSNVI-EIsytsPDPELAA-----AVANALAeayLEQNLELRREEARKALEFLE 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 221 LARTDLEMQIEGLNEELAYLKKNH-----EEWVPPILQEMKEFSSQLAgqvnvemdaapgvDLTRVLAEMREQYEAMAEK 295
Cdd:COG3206   182 EQLPELRKELEEAEAALEEFRQKNglvdlSEEAKLLLQQLSELESQLA-------------EARAELAEAEARLAALRAQ 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 296 NRRDVEAwffskteelnKEVASNTEMIQTSKTEITDLRRTMQELE----------IELQSQL-SMKAGLENSLAETECRY 364
Cdd:COG3206   249 LGSGPDA----------LPELLQSPVIQQLRAQLAELEAELAELSarytpnhpdvIALRAQIaALRAQLQQEAQRILASL 318

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034599643 365 ATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLdiktRLEQEIATYRSLLEGQDAKMAGIAIREA 432
Cdd:COG3206   319 EAELEALQAREASLQAQLAQLEARLAELPELEAELR----RLEREVEVARELYESLLQRLEEARLAEA 382
PRK11281 PRK11281
mechanosensitive channel MscK;
306-422 3.46e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 39.89  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  306 SKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAgLENSLAETEcryaTQLQQIQGLIGGLEAQLSEL 385
Cdd:PRK11281    80 EETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLRQ-LESRLAQTL----DQLQNAQNDLAEYNSQLVSL 154

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1034599643  386 RCEME-AQNQEYKMLldikTRLeQEIatyRSLLEGQDA 422
Cdd:PRK11281   155 QTQPErAQAALYANS----QRL-QQI---RNLLKGGKV 184
 
Name Accession Description Interval E-value
Filament pfam00038
Intermediate filament protein;
104-423 5.83e-140

Intermediate filament protein;


Pssm-ID: 459643 [Multi-domain]  Cd Length: 313  Bit Score: 402.76  E-value: 5.83e-140
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 104 NEKITMQNLNDRLASYLDKVRALEEANADLEVKIHDWYQKQTPtSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDN 183
Cdd:pfam00038   1 NEKEQLQELNDRLASYIDKVRFLEQQNKLLETKISELRQKKGA-EPSRLYSLYEKEIEDLRRQLDTLTVERARLQLELDN 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 184 ARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppilqEMKEFSSQLA 263
Cdd:pfam00038  80 LRLAAEDFRQKYEDELNLRTSAENDLVGLRKDLDEATLARVDLEAKIESLKEELAFLKKNHEE-------EVRELQAQVS 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 264 -GQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAWFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIE 342
Cdd:pfam00038 153 dTQVNVEMDAARKLDLTSALAEIRAQYEEIAAKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRTIQSLEIE 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 343 LQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDA 422
Cdd:pfam00038 233 LQSLKKQKASLERQLAETEERYELQLADYQELISELEAELQETRQEMARQLREYQELLNVKLALDIEIATYRKLLEGEEC 312


                  .
gi 1034599643 423 K 423
Cdd:pfam00038 313 R 313
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 122-427 6.01e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.98  E-value: 6.01e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  122 KVRALEEANADLEVKIHDWYQKQTptSPECDYSQYFKTIEELRDKIMATTIDNSRVILEIDNARLAADDFRLKYENELAL 201
Cdd:TIGR02168  685 KIEELEEKIAELEKALAELRKELE--ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAE 762

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  202 RQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHeewvppilqemKEFSSQLagqvnvemdaapgvDLTRV 281
Cdd:TIGR02168  763 IEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREAL-----------DELRAEL--------------TLLNE 817

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  282 LAEMREQYEAMAEKNRRDVEAWFfsktEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETE 361
Cdd:TIGR02168  818 EAANLRERLESLERRIAATERRL----EDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLR 893

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  362 CRYATQLQQIQGL---IGGLEAQLSELRCEMEA-QNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGI 427
Cdd:TIGR02168  894 SELEELSEELRELeskRSELRRELEELREKLAQlELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKI 963
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 194-432 4.75e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 4.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  194 KYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEEL----AYLKKNHEEWVPPILQEMKEFSSQLAGQVNVE 269
Cdd:TIGR02169  231 EKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLeelnKKIKDLGEEEQLRVKEKIGELEAEIASLERSI 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  270 MDAApgvDLTRVLAEMREQYEAMAEKNRRDVEAwFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIE------- 342
Cdd:TIGR02169  311 AEKE---RELEDAEERLAKLEAEIDKLLAEIEE-LEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEfaetrde 386

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  343 ---LQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLS--------------ELRCEMEAQNQEYKMLLDIKTR 405
Cdd:TIGR02169  387 lkdYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAgieakineleeekeDKALEIKKQEWKLEQLAADLSK 466

                          250       260       270
                   ....*....|....*....|....*....|.
gi 1034599643  406 LEQEI----ATYRSLLEGQDAKMAGIAIREA 432
Cdd:TIGR02169  467 YEQELydlkEEYDRVEKELSKLQRELAEAEA 497
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
148-432 5.66e-05

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 45.39  E-value: 5.66e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 148 SPECDYSQYFKTIEELRDKIMATTIDNSRVIlEI----DNARLAAddfrlKYENELA---LRQGVEADINGLRRVLDELT 220
Cdd:COG3206   108 DPLGEEASREAAIERLRKNLTVEPVKGSNVI-EIsytsPDPELAA-----AVANALAeayLEQNLELRREEARKALEFLE 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 221 LARTDLEMQIEGLNEELAYLKKNH-----EEWVPPILQEMKEFSSQLAgqvnvemdaapgvDLTRVLAEMREQYEAMAEK 295
Cdd:COG3206   182 EQLPELRKELEEAEAALEEFRQKNglvdlSEEAKLLLQQLSELESQLA-------------EARAELAEAEARLAALRAQ 248

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 296 NRRDVEAwffskteelnKEVASNTEMIQTSKTEITDLRRTMQELE----------IELQSQL-SMKAGLENSLAETECRY 364
Cdd:COG3206   249 LGSGPDA----------LPELLQSPVIQQLRAQLAELEAELAELSarytpnhpdvIALRAQIaALRAQLQQEAQRILASL 318

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034599643 365 ATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLdiktRLEQEIATYRSLLEGQDAKMAGIAIREA 432
Cdd:COG3206   319 EAELEALQAREASLQAQLAQLEARLAELPELEAELR----RLEREVEVARELYESLLQRLEEARLAEA 382
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 180-392 8.16e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 8.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 180 EIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEWVPPILQEMKE-F 258
Cdd:COG4942    35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRAlY 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 259 SSQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKnrrdveawffskTEELN---KEVASNTEMIQTSKTEITDLRRT 335
Cdd:COG4942   115 RLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQ------------AEELRadlAELAALRAELEAERAELEALLAE 182

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034599643 336 MQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQ 392
Cdd:COG4942   183 LEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAA 239
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 180-433 1.31e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.66  E-value: 1.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  180 EIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEWVPPILQEMKEFS 259
Cdd:TIGR02168  678 EIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELT 757

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  260 SQLAGQVNVEMDAAPGVDLTRVLAEMREQYEAMAEKNRRDVEAW------FFSKTEELNKEVASNTEMIQTSKTEITDLR 333
Cdd:TIGR02168  758 ELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALrealdeLRAELTLLNEEAANLRERLESLERRIAATE 837

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  334 RTMQELE---IELQSQLSMKAGLENSLAETECRYATQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEI 410
Cdd:TIGR02168  838 RRLEDLEeqiEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRREL 917

                          250       260
                   ....*....|....*....|...
gi 1034599643  411 ATYRSLLEGQDAKMAGIAIREAY 433
Cdd:TIGR02168  918 EELREKLAQLELRLEGLEVRIDN 940
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 186-432 2.37e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 186 LAADDFRLKYENELalrQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppILQEMKEFSSQLAgQ 265
Cdd:COG4942    16 AAQADAAAEAEAEL---EQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRA----LEQELAALEAELA-E 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 266 VNVEMDAapgvdLTRVLAEMREQYEAM---AEKNRRDVEAWFFSKTEELNKEVASNT---EMIQTSKTEITDLRRTMQEL 339
Cdd:COG4942    88 LEKEIAE-----LRAELEAQKEELAELlraLYRLGRQPPLALLLSPEDFLDAVRRLQylkYLAPARREQAEELRADLAEL 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 340 EIELQSQLSMKAGLENSLAETEcryaTQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKmlldiktRLEQEIATYRSLLEG 419
Cdd:COG4942   163 AALRAELEAERAELEALLAELE----EERAALEALKAERQKLLARLEKELAELAAELA-------ELQQEAEELEALIAR 231

                         250
                  ....*....|...
gi 1034599643 420 QDAKMAGIAIREA 432
Cdd:COG4942   232 LEAEAAAAAERTP 244
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 105-426 1.02e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 41.64  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  105 EKITMQN----LNDRLASYLDKVRALEEANADL-------EVKIHDWYQKQTP------TSPECD-----YSQYFKTIEE 162
Cdd:pfam15921  487 KKMTLESsertVSDLTASLQEKERAIEATNAEItklrsrvDLKLQELQHLKNEgdhlrnVQTECEalklqMAEKDKVIEI 566

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  163 LRDKIM--------------ATTIDNSRVILEIDNARLAADDFRLkyenelaLRQGVEADINGLRRVLDELTLARTDLem 228
Cdd:pfam15921  567 LRQQIEnmtqlvgqhgrtagAMQVEKAQLEKEINDRRLELQEFKI-------LKDKKDAKIRELEARVSDLELEKVKL-- 637

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  229 qIEGLNEELAYLKknheewvppilqEMKEFSSQLAGQVNVEMDAapgvdltrvLAEMREQYEAMAEKnrrdveawFFSKT 308
Cdd:pfam15921  638 -VNAGSERLRAVK------------DIKQERDQLLNEVKTSRNE---------LNSLSEDYEVLKRN--------FRNKS 687

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  309 EELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENslaetecryatQLQQIQGLIGGLEAQLSELRCE 388
Cdd:pfam15921  688 EEMETTTNKLKMQLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQK-----------QITAKRGQIDALQSKIQFLEEA 756

                          330       340       350
                   ....*....|....*....|....*....|....*...
gi 1034599643  389 MEAQNQEYKMLLDIKTRLEQEIATYRSllegQDAKMAG 426
Cdd:pfam15921  757 MTNANKEKHFLKEEKNKLSQELSTVAT----EKNKMAG 790
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 206-434 2.66e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 39.81  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 206 EADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppILQEMKEfssqlagqVNVEMDAApGVDLTRVLAEM 285
Cdd:COG3883    15 DPQIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNE----LQAELEA--------LQAEIDKL-QAEIAEAEAEI 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 286 REQYEAMAE------KNRRDVEAW-----------FFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLS 348
Cdd:COG3883    82 EERREELGEraralyRSGGSVSYLdvllgsesfsdFLDRLSALSKIADADADLLEELKADKAELEAKKAELEAKLAELEA 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 349 MKAGLENSLAETEcryaTQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIA 428
Cdd:COG3883   162 LKAELEAAKAELE----AQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAAAAAAAAAAAAAAAAAAAAAAAA 237


                  ....*.
gi 1034599643 429 IREAYS 434
Cdd:COG3883   238 AAAAAA 243
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 193-432 2.88e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 2.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 193 LKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppiLQEmkEFSSQLAGQVNVEMDA 272
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEE-----AQA--EEYELLAELARLEQDI 304

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 273 APGVDLTRVLAEMREQYEAMAEKNRRDVEAwFFSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAG 352
Cdd:COG1196   305 ARLEERRRELEERLEELEEELAELEEELEE-LEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEE 383

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 353 LENSLAETEcryaTQLQQIQGLIGGLEAQLSELRCEMEAQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIAIREA 432
Cdd:COG1196   384 LAEELLEAL----RAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEE 459
PRK11281 PRK11281
mechanosensitive channel MscK;
306-422 3.46e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 39.89  E-value: 3.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  306 SKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAgLENSLAETEcryaTQLQQIQGLIGGLEAQLSEL 385
Cdd:PRK11281    80 EETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETLSTLSLRQ-LESRLAQTL----DQLQNAQNDLAEYNSQLVSL 154

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1034599643  386 RCEME-AQNQEYKMLldikTRLeQEIatyRSLLEGQDA 422
Cdd:PRK11281   155 QTQPErAQAALYANS----QRL-QQI---RNLLKGGKV 184
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 158-431 5.27e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.15  E-value: 5.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 158 KTIEELRDKIMATTidnsrviLEIDNARLAADDFRLKYENELALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEEL 237
Cdd:COG1196   267 AELEELRLELEELE-------LELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEEL 339

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 238 AYLKKNHEEWVPPILQEMKEFSSQLAGQVNVEMDAAPGVD--LTRVLAEMREQYEAMAEKNRRDVEAwffSKTEELNKEV 315
Cdd:COG1196   340 EELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEelEELAEELLEALRAAAELAAQLEELE---EAEEALLERL 416

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 316 ASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETECRYATQLQQIQgligGLEAQLSELRCEMEAQNQE 395
Cdd:COG1196   417 ERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA----LLEAALAELLEELAEAAAR 492

                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1034599643 396 YKMLLDIKTRLEQEIATYRSLLEGQDAKMAGIAIRE 431
Cdd:COG1196   493 LLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAV 528
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 203-392 8.92e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 37.60  E-value: 8.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 203 QGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwvppILQEMKEFSSQLAgqvnvemdaapgvDLTRVL 282
Cdd:COG1579    13 QELDSELDRLEHRLKELPAELAELEDELAALEARLEAAKTELED----LEKEIKRLELEIE-------------EVEARI 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643 283 AEMREQyeAMAEKNRRDVEAwffskteeLNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLENSLAETEC 362
Cdd:COG1579    76 KKYEEQ--LGNVRNNKEYEA--------LQKEIESLKRRISDLEDEILELMERIEELEEELAELEAELAELEAELEEKKA 145

                         170       180       190
                  ....*....|....*....|....*....|
gi 1034599643 363 RYATQLQQIQGLIGGLEAQLSELRCEMEAQ 392
Cdd:COG1579   146 ELDEELAELEAELEELEAEREELAAKIPPE 175
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 200-421 9.99e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.51  E-value: 9.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  200 ALRQGVEADINGLRRVLDELTLARTDLEMQIEGLNEELAYLKKNHEEwVPPILQEMKEFSSQLagQVNVEMDAAPGVDLT 279
Cdd:TIGR02169  688 RELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEK-LKERLEELEEDLSSL--EQEIENVKSELKELE 764

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034599643  280 RVLAEMREQY----EAMAEKNRRDVEawffSKTEELNKEVASNTEMIQTSKTEITDLRRTMQELEIELQSQLSMKAGLEN 355
Cdd:TIGR02169  765 ARIEELEEDLhkleEALNDLEARLSH----SRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE 840

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034599643  356 SLAETECRYATQLQQIQGLIGGLEAQLSELRcEMEAQNQEY-KMLLDIKTRLEQEIATYRSLLEGQD 421
Cdd:TIGR02169  841 QRIDLKEQIKSIEKEIENLNGKKEELEEELE-ELEAALRDLeSRLGDLKKERDELEAQLRELERKIE 906
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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