Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034609765   47 RRGSPGILQGPNVCGSRFHAYCCPGWRTFPGRSQCVV 83
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034609765  627 GSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALC 670
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034609765 1659 GTCQNELAFNVTRKMCCCSYnIGQAWNRPCEACPTPISPDYQILC 1703
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034609765 1284 CEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC 1319
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034609765 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRAC 1194
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1034609765 2485 DNDECsAQPGPCGAHGHCHNTPGSFRCECHQGFTL 2519
Cdd:cd00054      1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1034609765  1028 DIDECRiSPDLCGQG-TCVNTPGSFECECFPGYESG 1062
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034609765 2403 CLDMDECSQVPKPCTFLCKNTKGSFLCSCPRGYLLEEDGRT 2443
Cdd:cd01475    184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034609765 1325 CVSQEHRCSPRGDCLNVPGSYRCTCRQGFAGDGFFC 1360
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1034609765  2528 DVNECDGPHRCQHG--CQNQLGGYRCSCPQGFT 2558
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1034609765  2126 DTDECSVGHPCGQG-TCTNVIGGFECACADGFEPGlmMTCE 2165
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034609765 2084 DVNECAENPGVC-TNGVCVNTDGSFRCECPFG 2114
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034609765 2446 DLDECTSRQHNCQ--FLCVNTVGAFTCRCPPG 2475
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034609765  1969 DIDECsEEPNLCLFG-TCTNSPGSFQCLCPPGFVlsdNGHRC 2009
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNC 38

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034609765  196 CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQ 228
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034609765  820 RCEVNLQGASLRSECC-ATLGAAWGSPCERCEI 851
Cdd:pfam00683    2 RCSNPLPGNVTKSECCcTSVGRAWGSPCELCPP 34

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034609765  1404 DVDECAQGNLCAFGS-CENLPGMFRCICNGGYEldrGGGNCT 1444
Cdd:smart00179    1 DIDECASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1034609765  2363 DVDECRMLaHLCAHG-ECINSLGSFRCHCQAGYTPDAT 2399
Cdd:smart00179    1 DIDECASG-NPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034609765 1800 GGACVGRNECREIPNVCSHGdCMDTEGSYMCLCHRGFQASADQ 1842
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1034609765   47 RRGSPGILQGPNVCGSRFHAYCCPGWRTFPGRSQCVV 83
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1034609765  627 GSCARPFPGTVTKSECCCANPDHGFGEPCQLCPAKDSAEFQALC 670
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1034609765 1659 GTCQNELAFNVTRKMCCCSYnIGQAWNRPCEACPTPISPDYQILC 1703
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034609765 1284 CEVGGHNCDSHASCLNIPGSFSCRCLPGWVGDGFEC 1319
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034609765 1159 CRVQNGGCDVHCINTEGSYRCSCGQGYSLMPDGRAC 1194
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1034609765 2485 DNDECsAQPGPCGAHGHCHNTPGSFRCECHQGFTL 2519
Cdd:cd00054      1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034609765  869 DVNECESFPGVCP-NGRCVNTAGSFRCECPEG 899
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034609765 2207 DVDECADGQQDCHaRGMECKNLIGTFACVCPPG 2239
Cdd:pfam07645    1 DVDECATGTHNCP-ANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034609765   572 DIDECQTPGICVNG-HCTNTEGSFRCQCLGGLavgTDGRVCV 612
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034609765  1071 DVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELtakGTACE 1112
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYTD---GRNCE 39

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1034609765 1761 CEDVDECGSRESPCQQNadCINIPGSYRCKCTRGYKLSP 1799
Cdd:cd01475    184 CVVPDLCATLSHVCQQV--CISTPGSYLCACTEGYALLE 220

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1034609765  2126 DTDECSVGHPCGQG-TCTNVIGGFECACADGFEPGlmMTCE 2165
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1034609765  1445 DINECADPVNCING-VCINTPGSYLCSCPQDFE 1476
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1034609765 1071 DVDECARDPLLCRGGTCTNTDGSYKCQCPPGHELT 1105
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034609765 2446 DLDECTSRQHNCQ--FLCVNTVGAFTCRCPPG 2475
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034609765 1071 DVDECARDPLLC-RGGTCTNTDGSYKCQCPPG 1101
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034609765  724 DVDECALNSLLCDNGWCQNSPGSYSCSCPPGFH 756
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1034609765   724 DVDECALNSLLCDNGWCQNSPGSYSCSCPPGFH 756
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034609765 2528 DVNECDGPHRCQHG--CQNQLGGYRCSCPQGFT 2558
Cdd:cd00054      1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034609765 1445 DINECADPVNCIN-GVCINTPGSYLCSCPQDFEL 1477
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|.
gi 1034609765   869 DVNECESFPGVCPNGRCVNTAGSFRCECPEG 899
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPG 31

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.

                           10        20        30
                   ....*....|....*....|....*....|...
gi 1034609765  196 CQHQLTGLVCTKALCCATVGRAWGLPCELCPAQ 228
Cdd:pfam00683    3 CSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|...
gi 1034609765  1280 DVDECEVGgHNCDSHASCLNIPGSFSCRCLPGW 1312
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1034609765  2166 DIDEC-SLNPLLCAFRCHNTEGSYLCTCPAGYTlreDGAMC 2205
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNC 38

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034609765  572 DIDECQTPGICVNGH-CTNTEGSFRCQCLGG 601
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCSCPPG 31

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034609765 1028 DIDECRiSPDLCG-QGTCVNTPGSFECECFPGYE 1060
Cdd:cd00054      1 DIDECA-SGNPCQnGGTCVNTVGSYRCSCPPGYT 33

Calcium-binding EGF-like domain;

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1034609765  1404 DVDECAQGNLCAFGS-CENLPGMFRCICNGGYEldrGGGNCT 1444
Cdd:smart00179    1 DIDECASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNCE 39

Calcium-binding EGF domain;

                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034609765  724 DVDECALNSLLCD-NGWCQNSPGSYSCSCPPG 754
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1034609765 2164 CEDIDECSLNPLLCAFRCHNTEGSYLCTCPAGYTLREDG 2202
Cdd:cd01475    184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDN 222

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                           10        20        30
                   ....*....|....*....|....*....|
gi 1034609765 2489 CSAQPGPCGAHGHCHNTPGSFRCECHQGFT 2518
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYT 30

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034609765 1404 DVDECAQGNLCAF-GSCENLPGMFRCICNGGYELDR 1438
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1034609765 1321 DLDECVSqEHRCSPRGDCLNVPGSYRCTCRQGFAGD 1356
Cdd:cd00054      1 DIDECAS-GNPCQNGGTCVNTVGSYRCSCPPGYTGR 35

Calcium-binding EGF-like domain;

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1034609765  1847 DIDEC-DRQPCGNG-TCKNIIGSYNCLCFPGFVVTHN 1881
Cdd:smart00179    1 DIDECaSGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1034609765 1800 GGACVGRNECREIPNVCSHGdCMDTEGSYMCLCHRGFQASADQ 1842
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222