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Conserved domains on  [gi|1034675045|ref|XP_016885253|]
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tafazzin isoform X9 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 57-178 1.07e-19

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


:

Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 81.93  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045  57 RREKGDGvYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAEChlNPIILPLWHVGMNDVLPnsPPYFP 136
Cdd:cd07989    76 DRGNGRS-AREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA--GVPIVPVAISGTWGSLP--KGKKL 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1034675045 137 RFGQKITVLIGKPFSAlpvlerlrAENKSAVEMRKALTDFIQ 178
Cdd:cd07989   151 PRPGRVTVRIGEPIPP--------EGLELAEEDRKELREKVR 184
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 57-178 1.07e-19

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 81.93  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045  57 RREKGDGvYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAEChlNPIILPLWHVGMNDVLPnsPPYFP 136
Cdd:cd07989    76 DRGNGRS-AREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA--GVPIVPVAISGTWGSLP--KGKKL 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1034675045 137 RFGQKITVLIGKPFSAlpvlerlrAENKSAVEMRKALTDFIQ 178
Cdd:cd07989   151 PRPGRVTVRIGEPIPP--------EGLELAEEDRKELREKVR 184
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 6-124 1.10e-13

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 64.68  E-value: 1.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045    6 AADICFTKELHSHFFSLGKCVPVCRGAeffqaenegkgvldtgrhmpgagkrrekgDGVYQKGMDFILEKLNHGDWVHIF 85
Cdd:smart00563  31 AKKELFYVPLLGWLLRLLGAIFIDRSN-----------------------------GRKARAALREAVELLKEGEWLLIF 81

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1034675045   86 PEGKVNMSSEFLRFKWGIGRLIAECHlnPIILPLWHVGM 124
Cdd:smart00563  82 PEGTRSRPGKLLPFKKGAARLALEAG--VPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 5-122 3.92e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 63.45  E-value: 3.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045   5 AAADICFTKeLHSHFFSLGKCVPVCRgaeffqaenegkgvldtgrhmpgagkrreKGDGVYQKGMDFILEKLNHGDWVHI 84
Cdd:pfam01553  46 AKKELFDIP-LVGWLMRLLGCIFIDR-----------------------------KNRKDAAGTLEYLVELLREGKLVVI 95

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1034675045  85 FPEGKVNMSSEFLRFKWGIGRLIAEchLNPIILPLWHV 122
Cdd:pfam01553  96 FPEGTRSREGELLPFKKGAFRLAIE--AGVPIVPVAIS 131
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 69-192 4.20e-11

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 59.64  E-value: 4.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045  69 MDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLnPIIlPLWHVGMNDVLPnsPPYFPRFGqKITVLIGK 148
Cdd:COG0204   106 LRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGV-PIV-PVAIDGTERALP--KGFLPRPG-KVTVRIGP 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034675045 149 PFSAlpvlERLRAENksavemRKALTDFIQEEFQHLKTQAEQLH 192
Cdd:COG0204   181 PIDP----SDLEGED------RRELAERLRAAIEALLAELRAEA 214
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 69-194 1.55e-03

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 38.75  E-value: 1.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045   69 MDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIgRLIAECHLNPIIlP-----LW-------HVGMNDVLPNSPPYfp 136
Cdd:PRK08633   501 LEFIRKALDDGEVVCIFPEGAITRNGQLNEFKRGF-ELIVKGTDVPII-PfyirgLWgsifsraSGKFLWRWPTRIPY-- 576

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034675045  137 rfgqKITVLIGKPfsaLPvlerlraENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNH 194
Cdd:PRK08633   577 ----PVTVAFGKP---MP-------AHSTAHEVKQAVFELSFDSWKSRKEALPPLAEA 620
 
Name Accession Description Interval E-value
LPLAT_AGPAT-like cd07989
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ...
 57-178 1.07e-19

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.


Pssm-ID: 153251 [Multi-domain]  Cd Length: 184  Bit Score: 81.93  E-value: 1.07e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045  57 RREKGDGvYQKGMDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAEChlNPIILPLWHVGMNDVLPnsPPYFP 136
Cdd:cd07989    76 DRGNGRS-AREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEA--GVPIVPVAISGTWGSLP--KGKKL 150

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1034675045 137 RFGQKITVLIGKPFSAlpvlerlrAENKSAVEMRKALTDFIQ 178
Cdd:cd07989   151 PRPGRVTVRIGEPIPP--------EGLELAEEDRKELREKVR 184
PlsC smart00563
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ...
 6-124 1.10e-13

Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.


Pssm-ID: 214724 [Multi-domain]  Cd Length: 118  Bit Score: 64.68  E-value: 1.10e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045    6 AADICFTKELHSHFFSLGKCVPVCRGAeffqaenegkgvldtgrhmpgagkrrekgDGVYQKGMDFILEKLNHGDWVHIF 85
Cdd:smart00563  31 AKKELFYVPLLGWLLRLLGAIFIDRSN-----------------------------GRKARAALREAVELLKEGEWLLIF 81

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1034675045   86 PEGKVNMSSEFLRFKWGIGRLIAECHlnPIILPLWHVGM 124
Cdd:smart00563  82 PEGTRSRPGKLLPFKKGAARLALEAG--VPIVPVAIRGT 118
Acyltransferase pfam01553
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ...
 5-122 3.92e-13

Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.


Pssm-ID: 366704 [Multi-domain]  Cd Length: 131  Bit Score: 63.45  E-value: 3.92e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045   5 AAADICFTKeLHSHFFSLGKCVPVCRgaeffqaenegkgvldtgrhmpgagkrreKGDGVYQKGMDFILEKLNHGDWVHI 84
Cdd:pfam01553  46 AKKELFDIP-LVGWLMRLLGCIFIDR-----------------------------KNRKDAAGTLEYLVELLREGKLVVI 95

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1034675045  85 FPEGKVNMSSEFLRFKWGIGRLIAEchLNPIILPLWHV 122
Cdd:pfam01553  96 FPEGTRSREGELLPFKKGAFRLAIE--AGVPIVPVAIS 131
PlsC COG0204
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ...
 69-192 4.20e-11

1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis


Pssm-ID: 439974 [Multi-domain]  Cd Length: 215  Bit Score: 59.64  E-value: 4.20e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045  69 MDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIGRLIAECHLnPIIlPLWHVGMNDVLPnsPPYFPRFGqKITVLIGK 148
Cdd:COG0204   106 LRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGV-PIV-PVAIDGTERALP--KGFLPRPG-KVTVRIGP 180

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1034675045 149 PFSAlpvlERLRAENksavemRKALTDFIQEEFQHLKTQAEQLH 192
Cdd:COG0204   181 PIDP----SDLEGED------RRELAERLRAAIEALLAELRAEA 214
LPLAT_AAK14816-like cd07992
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ...
 5-168 8.06e-05

Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.


Pssm-ID: 153254 [Multi-domain]  Cd Length: 203  Bit Score: 41.86  E-value: 8.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045   5 AAADIcFTKELHSHFFSLGKCVPVCRgaeffqaenegkgVLDTGRHMPGAGKRREKGDGVYQkgmdfILEKlnhGDWVHI 84
Cdd:cd07992    58 AKADL-FKNPLIGWLLESFGAIPVYR-------------PKDLARGGIGKISNAAVFDAVGE-----ALKA---GGAIGI 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045  85 FPEGKVNMSSEFLRFKWGIGRLIAECHLNPII-LPLWHVGMNdvlpnsppYF--PRFGQKITVLIGKPFSALP--VLERL 159
Cdd:cd07992   116 FPEGGSHDRPRLLPLKAGAARMALEALEAGQKdVKIVPVGLN--------YEdkSRFRSRVLVEFGKPISVSAfeEAEAS 187


                  ....*....
gi 1034675045 160 RAENKSAVE 168
Cdd:cd07992   188 RDVEKKLIN 196
PRK08633 PRK08633
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
 69-194 1.55e-03

2-acyl-glycerophospho-ethanolamine acyltransferase; Validated


Pssm-ID: 236315 [Multi-domain]  Cd Length: 1146  Bit Score: 38.75  E-value: 1.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034675045   69 MDFILEKLNHGDWVHIFPEGKVNMSSEFLRFKWGIgRLIAECHLNPIIlP-----LW-------HVGMNDVLPNSPPYfp 136
Cdd:PRK08633   501 LEFIRKALDDGEVVCIFPEGAITRNGQLNEFKRGF-ELIVKGTDVPII-PfyirgLWgsifsraSGKFLWRWPTRIPY-- 576

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034675045  137 rfgqKITVLIGKPfsaLPvlerlraENKSAVEMRKALTDFIQEEFQHLKTQAEQLHNH 194
Cdd:PRK08633   577 ----PVTVAFGKP---MP-------AHSTAHEVKQAVFELSFDSWKSRKEALPPLAEA 620
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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