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Conserved domains on  [gi|1039737460|ref|XP_017170098|]
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centrosomal protein of 95 kDa isoform X3 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5745 pfam19016
Domain of unknown function (DUF5745); This is a domain of unknown function found in ...
 55-107 1.76e-23

Domain of unknown function (DUF5745); This is a domain of unknown function found in Platyhelminthes. It shows homology with the calponin homology (CH) domain.


:

Pssm-ID: 465945  Cd Length: 59  Bit Score: 93.40  E-value: 1.76e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039737460  55 PRNQEDEAHNVQAVIDSLALDYLQVSLSHITGENIVKGDNESIRNLLEIFDGL 107
Cdd:pfam19016   7 PSSVEDRIHNIQAVIDSLANDVLNVDLSHITPEDIVDGDPEAIRNLLEIFVGI 59
CH_SF super family cl00030
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
 7-97 7.95e-04

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


The actual alignment was detected with superfamily member pfam00307:

Pssm-ID: 469584 [Multi-domain]  Cd Length: 109  Bit Score: 39.19  E-value: 7.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737460   7 EWVtiaNNLLFKCHIHLRIHELQD--CDANVFIALYQSILGEKVpDLIVLPRNQEDEAHNVQAVIDsLALDYLQVSLSHI 84
Cdd:pfam00307   9 RWI---NSHLAEYGPGVRVTNFTTdlRDGLALCALLNKLAPGLV-DKKKLNKSEFDKLENINLALD-VAEKKLGVPKVLI 83

                          90
                  ....*....|...
gi 1039737460  85 TGENIVKGDNESI 97
Cdd:pfam00307  84 EPEDLVEGDNKSV 96
 
Name Accession Description Interval E-value
DUF5745 pfam19016
Domain of unknown function (DUF5745); This is a domain of unknown function found in ...
 55-107 1.76e-23

Domain of unknown function (DUF5745); This is a domain of unknown function found in Platyhelminthes. It shows homology with the calponin homology (CH) domain.


Pssm-ID: 465945  Cd Length: 59  Bit Score: 93.40  E-value: 1.76e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039737460  55 PRNQEDEAHNVQAVIDSLALDYLQVSLSHITGENIVKGDNESIRNLLEIFDGL 107
Cdd:pfam19016   7 PSSVEDRIHNIQAVIDSLANDVLNVDLSHITPEDIVDGDPEAIRNLLEIFVGI 59
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 7-97 7.95e-04

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 39.19  E-value: 7.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737460   7 EWVtiaNNLLFKCHIHLRIHELQD--CDANVFIALYQSILGEKVpDLIVLPRNQEDEAHNVQAVIDsLALDYLQVSLSHI 84
Cdd:pfam00307   9 RWI---NSHLAEYGPGVRVTNFTTdlRDGLALCALLNKLAPGLV-DKKKLNKSEFDKLENINLALD-VAEKKLGVPKVLI 83

                          90
                  ....*....|...
gi 1039737460  85 TGENIVKGDNESI 97
Cdd:pfam00307  84 EPEDLVEGDNKSV 96
CH_NAV2-like cd21212
calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; ...
 12-101 5.24e-03

calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; This family includes neuron navigator 2 (NAV2) and NAV3, both of which contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. NAV2, also called helicase APC down-regulated 1 (HELAD1), pore membrane and/or filament-interacting-like protein 2 (POMFIL2), retinoic acid inducible in neuroblastoma 1 (RAINB1), Steerin-2 (STEERIN2), or Unc-53 homolog 2 (unc53H2), possesses 3' to 5' helicase activity and exonuclease activity. It is involved in neuronal development, specifically in the development of different sensory organs. NAV3, also called pore membrane and/or filament-interacting-like protein 1 (POMFIL1), Steerin-3 (STEERIN3), or Unc-53 homolog 3 (unc53H3), may regulate IL2 production by T-cells. It may be involved in neuron regeneration.


Pssm-ID: 409061  Cd Length: 105  Bit Score: 36.79  E-value: 5.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737460  12 ANNLLFKCHIHLRIHELQD--CDANVFIALYQSILGEKVPDLIVLPRNQEDEAHNVQAvidslALDYLQ---VSLSHITG 86
Cdd:cd21212     9 ANHYLEKGGHKRIITDLQKdlGDGLTLVNLIEAVAGEKVPGIHSRPKTRAQKLENIQA-----CLQFLAalgVDVQGITA 83

                          90
                  ....*....|....*
gi 1039737460  87 ENIVKGDNESIRNLL 101
Cdd:cd21212    84 EDIVDGNLKAILGLF 98
 
Name Accession Description Interval E-value
DUF5745 pfam19016
Domain of unknown function (DUF5745); This is a domain of unknown function found in ...
 55-107 1.76e-23

Domain of unknown function (DUF5745); This is a domain of unknown function found in Platyhelminthes. It shows homology with the calponin homology (CH) domain.


Pssm-ID: 465945  Cd Length: 59  Bit Score: 93.40  E-value: 1.76e-23
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1039737460  55 PRNQEDEAHNVQAVIDSLALDYLQVSLSHITGENIVKGDNESIRNLLEIFDGL 107
Cdd:pfam19016   7 PSSVEDRIHNIQAVIDSLANDVLNVDLSHITPEDIVDGDPEAIRNLLEIFVGI 59
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
 7-97 7.95e-04

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596 [Multi-domain]  Cd Length: 109  Bit Score: 39.19  E-value: 7.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737460   7 EWVtiaNNLLFKCHIHLRIHELQD--CDANVFIALYQSILGEKVpDLIVLPRNQEDEAHNVQAVIDsLALDYLQVSLSHI 84
Cdd:pfam00307   9 RWI---NSHLAEYGPGVRVTNFTTdlRDGLALCALLNKLAPGLV-DKKKLNKSEFDKLENINLALD-VAEKKLGVPKVLI 83

                          90
                  ....*....|...
gi 1039737460  85 TGENIVKGDNESI 97
Cdd:pfam00307  84 EPEDLVEGDNKSV 96
CH_NAV2-like cd21212
calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; ...
 12-101 5.24e-03

calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; This family includes neuron navigator 2 (NAV2) and NAV3, both of which contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. NAV2, also called helicase APC down-regulated 1 (HELAD1), pore membrane and/or filament-interacting-like protein 2 (POMFIL2), retinoic acid inducible in neuroblastoma 1 (RAINB1), Steerin-2 (STEERIN2), or Unc-53 homolog 2 (unc53H2), possesses 3' to 5' helicase activity and exonuclease activity. It is involved in neuronal development, specifically in the development of different sensory organs. NAV3, also called pore membrane and/or filament-interacting-like protein 1 (POMFIL1), Steerin-3 (STEERIN3), or Unc-53 homolog 3 (unc53H3), may regulate IL2 production by T-cells. It may be involved in neuron regeneration.


Pssm-ID: 409061  Cd Length: 105  Bit Score: 36.79  E-value: 5.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039737460  12 ANNLLFKCHIHLRIHELQD--CDANVFIALYQSILGEKVPDLIVLPRNQEDEAHNVQAvidslALDYLQ---VSLSHITG 86
Cdd:cd21212     9 ANHYLEKGGHKRIITDLQKdlGDGLTLVNLIEAVAGEKVPGIHSRPKTRAQKLENIQA-----CLQFLAalgVDVQGITA 83

                          90
                  ....*....|....*
gi 1039737460  87 ENIVKGDNESIRNLL 101
Cdd:cd21212    84 EDIVDGNLKAILGLF 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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