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Conserved domains on  [gi|1039738591|ref|XP_017170310|]
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ankyrin repeat domain 36 isoform X2 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-240 4.74e-45

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.74  E-value: 4.74e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   38 HKAASVGDIPQVQKMLEFGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVK 117
Cdd:COG0666     58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  118 ILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDN 197
Cdd:COG0666    138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039738591  198 CKRSALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAV 240
Cdd:COG0666    218 DGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-240 4.74e-45

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.74  E-value: 4.74e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   38 HKAASVGDIPQVQKMLEFGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVK 117
Cdd:COG0666     58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  118 ILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDN 197
Cdd:COG0666    138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039738591  198 CKRSALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAV 240
Cdd:COG0666    218 DGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 57-240 2.61e-21

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 98.20  E-value: 2.61e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   57 DIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQH------EIcVKILLENGADSNAVD 130
Cdd:PHA03100    25 DDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvkEI-VKLLLEYGANVNAPD 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  131 IHQNTSLHYTVYNK--DTTIAAKLLAFNADTEVKTKNGYTPLILAV--LENKQEMVELLLQAAANINALDNCKR------ 200
Cdd:PHA03100   104 NNGITPLLYAISKKsnSYSIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKNRVNYllsygv 183

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039738591  201 ----------SALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAV 240
Cdd:PHA03100   184 pinikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI 233
Ank_2 pfam12796
Ankyrin repeats (3 copies);
37-130 5.25e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.16  E-value: 5.25e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   37 IHKAASVGDIPQVQKMLEFGdIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYdCNIEARDREEsTALIKATQRQHEICV 116
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1039738591  117 KILLENGADSNAVD 130
Cdd:pfam12796   78 KLLLEKGADINVKD 91
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 35-243 2.55e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 58.55  E-value: 2.55e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   35 KRIHKAASVGDIPQVQKML-EFGDIDVNVTDRKKRTALHYACAHGQS-EMVSLLLWYDCNIEARDreesTALIKATQRQH 112
Cdd:TIGR00870   19 KAFLPAAERGDLASVYRDLeEPKKLNINCPDRLGRSALFVAAIENENlELTELLLNLSCRGAVGD----TLLHAISLEYV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  113 EICVKILLENGAdsnavdIHQNTSLHYTVYNKDTtiaakllafnaDTEVKtknGYTPLILAVLENKQEMVELLLQAAANI 192
Cdd:TIGR00870   95 DAVEAILLHLLA------AFRKSGPLELANDQYT-----------SEFTP---GITALHLAAHRQNYEIVKLLLERGASV 154

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039738591  193 NALDNCK--------------RSALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAVFET 243
Cdd:TIGR00870  155 PARACGDffvksqgvdsfyhgESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLVMEN 219
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 69-187 2.96e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 2.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   69 TALHYACAHGQSEMVSLLLWYDCN-IEARD-----REESTALIK--------ATQRQHEICVKILLENGADSNAVDIHQN 134
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADvVSPRAtgtffRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039738591  135 TSLHYTVYNKDTTIAAKLLAF--NADTE--------VKTKNGYTPLILAVLENKQEMVELLLQ 187
Cdd:cd22192    171 TVLHILVLQPNKTFACQMYDLilSYDKEddlqpldlVPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 165-194 2.24e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.24e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1039738591   165 NGYTPLILAVLENKQEMVELLLQAAANINA 194
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
38-240 4.74e-45

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 164.74  E-value: 4.74e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   38 HKAASVGDIPQVQKMLEFGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVK 117
Cdd:COG0666     58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  118 ILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDN 197
Cdd:COG0666    138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDN 217

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039738591  198 CKRSALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAV 240
Cdd:COG0666    218 DGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAA 260
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
49-240 3.85e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 153.57  E-value: 3.85e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   49 VQKMLEFGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVKILLENGADSNA 128
Cdd:COG0666     36 LLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNA 115

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  129 VDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDNCKRSALIHAVR 208
Cdd:COG0666    116 RDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAE 195

                          170       180       190
                   ....*....|....*....|....*....|..
gi 1039738591  209 TQSKNMISLLLQQGANASLVDIYGATAQSYAV 240
Cdd:COG0666    196 NGHLEIVKLLLEAGADVNAKDNDGKTALDLAA 227
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
37-235 1.05e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 149.33  E-value: 1.05e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   37 IHKAASVGDIPQVQKMLEFGdIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICV 116
Cdd:COG0666     91 LHAAARNGDLEIVKLLLEAG-ADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIV 169

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  117 KILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALD 196
Cdd:COG0666    170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKD 249

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1039738591  197 NCKRSALIHAVRTQSKNMISLLLQQGANASLVDIYGATA 235
Cdd:COG0666    250 KDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
37-203 4.30e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.30  E-value: 4.30e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   37 IHKAASVGDIPQVQKMLEFGdIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICV 116
Cdd:COG0666    124 LHLAAYNGNLEIVKLLLEAG-ADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  117 KILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALD 196
Cdd:COG0666    203 KLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282


                   ....*..
gi 1039738591  197 NCKRSAL 203
Cdd:COG0666    283 LDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
53-240 2.63e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 121.98  E-value: 2.63e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   53 LEFGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVKILLENGADSNAVDIH 132
Cdd:COG0666      7 LLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG 86

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  133 QNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDNCKRSALIHAVRTQSK 212
Cdd:COG0666     87 GNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNL 166

                          170       180
                   ....*....|....*....|....*...
gi 1039738591  213 NMISLLLQQGANASLVDIYGATAQSYAV 240
Cdd:COG0666    167 EIVKLLLEAGADVNARDNDGETPLHLAA 194
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 57-240 2.61e-21

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 98.20  E-value: 2.61e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   57 DIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQH------EIcVKILLENGADSNAVD 130
Cdd:PHA03100    25 DDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvkEI-VKLLLEYGANVNAPD 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  131 IHQNTSLHYTVYNK--DTTIAAKLLAFNADTEVKTKNGYTPLILAV--LENKQEMVELLLQAAANINALDNCKR------ 200
Cdd:PHA03100   104 NNGITPLLYAISKKsnSYSIVEYLLDNGANVNIKNSDGENLLHLYLesNKIDLKILKLLIDKGVDINAKNRVNYllsygv 183

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039738591  201 ----------SALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAV 240
Cdd:PHA03100   184 pinikdvygfTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAI 233
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
81-241 7.52e-21

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.64  E-value: 7.52e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   81 EMVSLLLWYDCNIEARDREESTALIKATQRQHEICVKILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTE 160
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  161 VKTKNGYTPLILAVLENKQEMVELLLQAAANINALDNCKRSALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAV 240
Cdd:COG0666     82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAA 161


                   .
gi 1039738591  241 F 241
Cdd:COG0666    162 A 162
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 42-232 6.27e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 91.18  E-value: 6.27e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   42 SVGDIPQVQK-----MLEFGdIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICV 116
Cdd:PHA02874    95 SILPIPCIEKdmiktILDCG-IDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDII 173

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  117 KILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQeMVELLLQAAAnINALD 196
Cdd:PHA02874   174 KLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS-AIELLINNAS-INDQD 251

                          170       180       190
                   ....*....|....*....|....*....|....*..
gi 1039738591  197 NCKRSALIHAVRTQ-SKNMISLLLQQGANASLVDIYG 232
Cdd:PHA02874   252 IDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKG 288
Ank_2 pfam12796
Ankyrin repeats (3 copies);
37-130 5.25e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.16  E-value: 5.25e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   37 IHKAASVGDIPQVQKMLEFGdIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYdCNIEARDREEsTALIKATQRQHEICV 116
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 1039738591  117 KILLENGADSNAVD 130
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 15-240 2.68e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 86.47  E-value: 2.68e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   15 SFRHAENqepprYLTGY--MPVKRIHKAASVGDIPQVQKMLEFGdIDVNVTDRKKRTALHYACAH----GQSEMVSLLLw 88
Cdd:PHA02878    22 YIDHTEN-----YSTSAslIPFIPLHQAVEARNLDVVKSLLTRG-HNVNQPDHRDLTPLHIICKEpnklGMKEMIRSIN- 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   89 yDCNIEARDREESTALikaTQRQHEIcVKILLENGADSN-AVDIHQNTSLHYTvYNKDTTIAAKLLAFNADTEVKTKN-G 166
Cdd:PHA02878    95 -KCSVFYTLVAIKDAF---NNRNVEI-FKIILTNRYKNIqTIDLVYIDKKSKD-DIIEAEITKLLLSYGADINMKDRHkG 168

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039738591  167 YTPLILAVLENKQEMVELLLQAAANINALDNCKRSALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAV 240
Cdd:PHA02878   169 NTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV 242
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 49-211 4.21e-17

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 86.09  E-value: 4.21e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   49 VQKMLEFGdIDVNVTDRKK-RTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVKILLENGADSN 127
Cdd:PHA02878   150 TKLLLSYG-ADINMKDRHKgNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTD 228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  128 AVDIHQNTSLHYTV-YNKDTTIAAKLLAFNADTEVK-TKNGYTPLILAVleNKQEMVELLLQAAANINALDNCKRSALIH 205
Cdd:PHA02878   229 ARDKCGNTPLHISVgYCKDYDILKLLLEHGVDVNAKsYILGLTALHSSI--KSERKLKLLLEYGADINSLNSYKLTPLSS 306


                   ....*.
gi 1039738591  206 AVRTQS 211
Cdd:PHA02878   307 AVKQYL 312
Ank_2 pfam12796
Ankyrin repeats (3 copies);
71-196 5.54e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.08  E-value: 5.54e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   71 LHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVKILLENgADSNAVDihqntslhytvynkdttiaa 150
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-------------------- 59

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1039738591  151 kllafnadtevktkNGYTPLILAVLENKQEMVELLLQAAANINALD 196
Cdd:pfam12796   60 --------------NGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 31-231 6.33e-16

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 81.64  E-value: 6.33e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   31 YMPVKRIHKAASVGDIPQVQKMLEFGdIDVNVTDRKKRTALHYACAHGQS-----EMVSLLLWYDCNIEARDREESTAL- 104
Cdd:PHA03100    33 KKPVLPLYLAKEARNIDVVKILLDNG-ADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLl 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  105 --IKATQRQHEIcVKILLENGADSNAVDIHQNTSLH-YTVYNKDTT------------IAAK-----LLAFNADTEVKTK 164
Cdd:PHA03100   112 yaISKKSNSYSI-VEYLLDNGANVNIKNSDGENLLHlYLESNKIDLkilkllidkgvdINAKnrvnyLLSYGVPINIKDV 190

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039738591  165 NGYTPLILAVLENKQEMVELLLQAAANINALDNCKRSALIHAVRTQSKNMISLLLQQGANASLVDIY 231
Cdd:PHA03100   191 YGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIET 257
Ank_2 pfam12796
Ankyrin repeats (3 copies);
137-229 2.07e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.84  E-value: 2.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  137 LHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQaAANINALDNcKRSALIHAVRTQSKNMIS 216
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039738591  217 LLLQQGANASLVD 229
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 30-228 3.44e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 79.26  E-value: 3.44e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   30 GYMPVKRihkAASVGDIPQVQKMLEFGDI-DVNVTDrkKRTALHYACAHGQSEMVSLLLwyDCNIEARD---REESTALI 105
Cdd:PHA02875    35 GISPIKL---AMKFRDSEAIKLLMKHGAIpDVKYPD--IESELHDAVEEGDVKAVEELL--DLGKFADDvfyKDGMTPLH 107

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  106 KATQRQHEICVKILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELL 185
Cdd:PHA02875   108 LATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....
gi 1039738591  186 LQAAANINALD-NCKRSALIHAVRTQSKNMISLLLQQGANASLV 228
Cdd:PHA02875   188 LDSGANIDYFGkNGCVAALCYAIENNKIDIVRLFIKRGADCNIM 231
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 49-239 8.52e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 79.34  E-value: 8.52e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   49 VQKMLEFGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWY--DCNIEARD---------------------------RE 99
Cdd:PHA02876   160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYgaDVNIIALDdlsvlecavdsknidtikaiidnrsniNK 239

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  100 ESTALIKATQRQHEICVKILLENGADSNAVDIHQNTSLHYTVYNKD-TTIAAKLLAFNADTEVKTKNGYTPLILAVLEN- 177
Cdd:PHA02876   240 NDLSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPLYLMAKNGy 319

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039738591  178 KQEMVELLLQAAANINALDNCKRSALiHAVRT--QSKNMISLLLQQGANASLVDIYGATAQSYA 239
Cdd:PHA02876   320 DTENIRTLIMLGADVNAADRLYITPL-HQASTldRNKDIVITLLELGANVNARDYCDKTPIHYA 382
PHA03095 PHA03095
ankyrin-like protein; Provisional
 116-235 3.55e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 73.52  E-value: 3.55e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  116 VKILLENGADSNAVDIHQNTSLHYTVYN---KDTTIAAKLLAFNADTEVKTKNGYTPLILAVL-ENKQEMVELLLQAAAN 191
Cdd:PHA03095    30 VRRLLAAGADVNFRGEYGKTPLHLYLHYsseKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYnATTLDVIKLLIKAGAD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1039738591  192 INALDNCKRSALiHA-VRTQS--KNMISLLLQQGANASLVDIYGATA 235
Cdd:PHA03095   110 VNAKDKVGRTPL-HVyLSGFNinPKVIRLLLRKGADVNALDLYGMTP 155
PHA03095 PHA03095
ankyrin-like protein; Provisional
 52-229 9.45e-13

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 71.98  E-value: 9.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   52 MLEFGdIDVNVTDRKKRTALH-YACAHGQS-EMVSLLLWYDCNIEARDREESTAL--IKATQRQHEICVKILLENGADSN 127
Cdd:PHA03095   138 LLRKG-ADVNALDLYGMTPLAvLLKSRNANvELLRLLIDAGADVYAVDDRFRSLLhhHLQSFKPRARIVRELIRAGCDPA 216

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  128 AVDIHQNTSLHY--TVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDNCKRSALIH 205
Cdd:PHA03095   217 ATDMLGNTPLHSmaTGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSL 296

                          170       180
                   ....*....|....*....|....
gi 1039738591  206 AVRTQSKNMISLLLQQGANASLVD 229
Cdd:PHA03095   297 MVRNNNGRAVRAALAKNPSAETVA 320
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 45-223 2.93e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 71.25  E-value: 2.93e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   45 DIPQVQKMLEFGdIDVNVTDRKKRTALHYACAHGQ-SEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVKILLENG 123
Cdd:PHA02876   320 DTENIRTLIMLG-ADVNAADRLYITPLHQASTLDRnKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYG 398

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  124 ADSNAVDIHQNTSLHYTVYNKDTTIAAKLLaFNADTEVKTKNGY--TPLILAVLEN-KQEMVELLLQAAANINALDNCKR 200
Cdd:PHA02876   399 ADIEALSQKIGTALHFALCGTNPYMSVKTL-IDRGANVNSKNKDlsTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQ 477

                          170       180
                   ....*....|....*....|...
gi 1039738591  201 SALIHAVRTQSknMISLLLQQGA 223
Cdd:PHA02876   478 YPLLIALEYHG--IVNILLHYGA 498
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 32-234 4.31e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.48  E-value: 4.31e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   32 MPVKRIHKAASVGDIPQVQKMLEFGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNI------------------ 93
Cdd:PHA02876    40 IPFTAIHQALQLRQIDIVEEIIQQNPELIYITDHKCHSTLHTICIIPNVMDIVISLTLDCDIildikyasiilnkhklde 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   94 ------------------EARDREESTALIKATQRQHEICV-KILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLA 154
Cdd:PHA02876   120 acihilkeaisgndihydKINESIEYMKLIKERIQQDELLIaEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLS 199

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  155 FNADTEVKTKNGYTPL-----------ILAVLENKQ------------------EMVELLLQAAANINALDNCKRSALIH 205
Cdd:PHA02876   200 YGADVNIIALDDLSVLecavdsknidtIKAIIDNRSninkndlsllkairnedlETSLLLYDAGFSVNSIDDCKNTPLHH 279

                          250       260       270
                   ....*....|....*....|....*....|
gi 1039738591  206 AVRTQS-KNMISLLLQQGANASLVDIYGAT 234
Cdd:PHA02876   280 ASQAPSlSRLVPKLLERGADVNAKNIKGET 309
PHA03095 PHA03095
ankyrin-like protein; Provisional
 49-239 1.24e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.51  E-value: 1.24e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   49 VQKMLEFGdIDVNVTDRKKRTALH-YACAHGQSEMVSLLLWYDCNIEARDREESTALIK--ATQRQHEICVKILLENGAD 125
Cdd:PHA03095    66 VRLLLEAG-ADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVylSGFNINPKVIRLLLRKGAD 144

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  126 SNAVDIHQNTSLHYTVYNKDTTIaakllafnadtevktkngytplilavlenkqEMVELLLQAAANINALDNCKRSAL-I 204
Cdd:PHA03095   145 VNALDLYGMTPLAVLLKSRNANV-------------------------------ELLRLLIDAGADVYAVDDRFRSLLhH 193

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1039738591  205 HAVRTQSKN-MISLLLQQGANASLVDIYGATAQSYA 239
Cdd:PHA03095   194 HLQSFKPRArIVRELIRAGCDPAATDMLGNTPLHSM 229
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 40-240 2.36e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 67.32  E-value: 2.36e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   40 AASVGDIPQVQKMLEFGdIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVKIL 119
Cdd:PHA02875     9 AILFGELDIARRLLDIG-INPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEEL 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  120 LENGADSNAVDIHQ-NTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDNC 198
Cdd:PHA02875    88 LDLGKFADDVFYKDgMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCC 167

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|...
gi 1039738591  199 KRSALIHAVRTQSKNMISLLLQQGANASLVDIYG-ATAQSYAV 240
Cdd:PHA02875   168 GCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGcVAALCYAI 210
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 44-226 6.95e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 66.14  E-value: 6.95e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   44 GDIPQVQKMLEFGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQ-RQHEIcVKILLEN 122
Cdd:PHA02874    12 GDIEAIEKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKiGAHDI-IKLLIDN 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  123 GADS-----------------------NAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQ 179
Cdd:PHA02874    91 GVDTsilpipciekdmiktildcgidvNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFF 170

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*..
gi 1039738591  180 EMVELLLQAAANINALDNCKRSALIHAVRTQSKNMISLLLQQGANAS 226
Cdd:PHA02874   171 DIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIM 217
Ank_5 pfam13857
Ankyrin repeats (many copies);
52-107 5.63e-10

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 56.20  E-value: 5.63e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039738591   52 MLEFGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKA 107
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 40-194 7.30e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 63.73  E-value: 7.30e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   40 AASVGDIPQVQKMLEFGdIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVKIL 119
Cdd:PLN03192   532 VASTGNAALLEELLKAK-LDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRIL 610

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039738591  120 LENGADSNAvdiHQNTSLHYTVYNK-DTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINA 194
Cdd:PLN03192   611 YHFASISDP---HAAGDLLCTAAKRnDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDK 683
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
116-242 8.79e-10

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 61.51  E-value: 8.79e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  116 VKILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINAL 195
Cdd:COG0666      4 LLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAK 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1039738591  196 DNCKRSALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAVFE 242
Cdd:COG0666     84 DDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYN 130
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 116-198 3.99e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.07  E-value: 3.99e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  116 VKILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINAL 195
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177


                   ...
gi 1039738591  196 DNC 198
Cdd:PTZ00322   178 GAN 180
Ank_4 pfam13637
Ankyrin repeats (many copies);
37-87 5.89e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 5.89e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039738591   37 IHKAASVGDIPQVQKMLEFGdIDVNVTDRKKRTALHYACAHGQSEMVSLLL 87
Cdd:pfam13637    5 LHAAAASGHLELLRLLLEKG-ADINAVDGNGETALHFAASNGNVEVLKLLL 54
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 35-243 2.55e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 58.55  E-value: 2.55e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   35 KRIHKAASVGDIPQVQKML-EFGDIDVNVTDRKKRTALHYACAHGQS-EMVSLLLWYDCNIEARDreesTALIKATQRQH 112
Cdd:TIGR00870   19 KAFLPAAERGDLASVYRDLeEPKKLNINCPDRLGRSALFVAAIENENlELTELLLNLSCRGAVGD----TLLHAISLEYV 94

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  113 EICVKILLENGAdsnavdIHQNTSLHYTVYNKDTtiaakllafnaDTEVKtknGYTPLILAVLENKQEMVELLLQAAANI 192
Cdd:TIGR00870   95 DAVEAILLHLLA------AFRKSGPLELANDQYT-----------SEFTP---GITALHLAAHRQNYEIVKLLLERGASV 154

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039738591  193 NALDNCK--------------RSALIHAVRTQSKNMISLLLQQGANASLVDIYGATAQSYAVFET 243
Cdd:TIGR00870  155 PARACGDffvksqgvdsfyhgESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLVMEN 219
Ank_4 pfam13637
Ankyrin repeats (many copies);
166-219 1.12e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 1.12e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039738591  166 GYTPLILAVLENKQEMVELLLQAAANINALDNCKRSALIHAVRTQSKNMISLLL 219
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 51-197 3.43e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 54.26  E-value: 3.43e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   51 KMLEFGDIDVNVTDRKKRTALHYAC--AHGQSEMVSLLLWYDCNIEARDREESTALIKATQrqHEICVKI----LLENGA 124
Cdd:PHA03095   171 RLLIDAGADVYAVDDRFRSLLHHHLqsFKPRARIVRELIRAGCDPAATDMLGNTPLHSMAT--GSSCKRSlvlpLLIAGI 248

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039738591  125 DSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDN 197
Cdd:PHA03095   249 SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVAA 321
Ank_4 pfam13637
Ankyrin repeats (many copies);
68-120 1.06e-06

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 46.88  E-value: 1.06e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039738591   68 RTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQHEICVKILL 120
Cdd:pfam13637    2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
119-173 2.37e-06

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.80  E-value: 2.37e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039738591  119 LLENG-ADSNAVDIHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKNGYTPLILA 173
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 165-197 8.06e-06

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 43.82  E-value: 8.06e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039738591  165 NGYTPLILAVLE-NKQEMVELLLQAAANINALDN 197
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 69-187 2.96e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 48.47  E-value: 2.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   69 TALHYACAHGQSEMVSLLLWYDCN-IEARD-----REESTALIK--------ATQRQHEICVKILLENGADSNAVDIHQN 134
Cdd:cd22192     91 TALHIAVVNQNLNLVRELIARGADvVSPRAtgtffRPGPKNLIYygehplsfAACVGNEEIVRLLIEHGADIRAQDSLGN 170

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039738591  135 TSLHYTVYNKDTTIAAKLLAF--NADTE--------VKTKNGYTPLILAVLENKQEMVELLLQ 187
Cdd:cd22192    171 TVLHILVLQPNKTFACQMYDLilSYDKEddlqpldlVPNNQGLTPFKLAAKEGNIVMFQHLVQ 233
Ank_5 pfam13857
Ankyrin repeats (many copies);
152-206 1.20e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 41.18  E-value: 1.20e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1039738591  152 LLAFNADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDNCKRSALIHA 206
Cdd:pfam13857    2 LEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 68-98 1.92e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 1.92e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039738591   68 RTALHYACAH-GQSEMVSLLLWYDCNIEARDR 98
Cdd:pfam00023    3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 165-194 2.24e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.49  E-value: 2.24e-04
                            10        20        30
                    ....*....|....*....|....*....|
gi 1039738591   165 NGYTPLILAVLENKQEMVELLLQAAANINA 194
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02798 PHA02798
ankyrin-like protein; Provisional
 81-197 2.48e-04

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 45.21  E-value: 2.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   81 EMVSLLLWYDCNIEARDREESTAL------IKATQRQHEIcVKILLENGADSNAVDIHQNTSLHYTVYNK---DTTIAAK 151
Cdd:PHA02798    52 DIVKLFINLGANVNGLDNEYSTPLctilsnIKDYKHMLDI-VKILIENGADINKKNSDGETPLYCLLSNGyinNLEILLF 130

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1039738591  152 LLAFNADTEVKTKNGYTPLILAVLENKQ---EMVELLLQAAANINALDN 197
Cdd:PHA02798   131 MIENGADTTLLDKDGFTMLQVYLQSNHHidiEIIKLLLEKGVDINTHNN 179
PHA03095 PHA03095
ankyrin-like protein; Provisional
 125-235 2.80e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 45.02  E-value: 2.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  125 DSNAVDIHQNTSLHYTVYNKDTTIA--AKLLAFNADTEVKTKNGYTPLILAV---LENKQEMVELLLQAAANINALDNCK 199
Cdd:PHA03095     4 DESVDIIMEAALYDYLLNASNVTVEevRRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGADVNAPERCG 83

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1039738591  200 RSALIHAVRTQSK-NMISLLLQQGANASLVDIYGATA 235
Cdd:PHA03095    84 FTPLHLYLYNATTlDVIKLLIKAGADVNAKDKVGRTP 120
PHA02989 PHA02989
ankyrin repeat protein; Provisional
 89-224 4.05e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222954 [Multi-domain]  Cd Length: 494  Bit Score: 44.35  E-value: 4.05e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   89 YDCNIEARDREESTALIKATQRQHEIcVKILLENGADSN--------AVDIHQNTSLHYTVYNKDTTIaakLLAFNADTE 160
Cdd:PHA02989    27 FDVNEEYRGNSILLLYLKRKDVKIKI-VKLLIDNGADVNykgyietpLCAVLRNREITSNKIKKIVKL---LLKFGADIN 102

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  161 VKTKNGYTPLILAVLE---NKQEMVELLLQAAANINALDNCKRSALIHAVRTQ---SKNMISLLLQQGAN 224
Cdd:PHA02989   103 LKTFNGVSPIVCFIYNsniNNCDMLRFLLSKGINVNDVKNSRGYNLLHMYLESfsvKKDVIKILLSFGVN 172
Ank_4 pfam13637
Ankyrin repeats (many copies);
100-153 4.46e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 4.46e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039738591  100 ESTALIKATQRQHEICVKILLENGADSNAVDIHQNTSLHYTVYNKDTTIAAKLL 153
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 94-213 1.15e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 43.21  E-value: 1.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   94 EARDREESTAL-IKATQRQHEIcVKILLENGADsnaVDIHqntslhytvynkdttiaAKLLAFNAdtevKTKN-----GY 167
Cdd:cd22194    135 TEEAYEGQTALnIAIERRQGDI-VKLLIAKGAD---VNAH-----------------AKGVFFNP----KYKHegfyfGE 189

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1039738591  168 TPLILAVLENKQEMVELLLQAAANINALDNCKRSALIHAVRTQSKN 213
Cdd:cd22194    190 TPLALAACTNQPEIVQLLMEKESTDITSQDSRGNTVLHALVTVAED 235
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 99-232 2.99e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 2.99e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   99 EESTALIKATQRQHEICVKILLENGADSNavdiHQNTSLHYTVYNKDTTIAAKLLAFNADTEVKTKngytplILAVLENK 178
Cdd:PHA02874    34 ETTTPLIDAIRSGDAKIVELFIKHGADIN----HINTKIPHPLLTAIKIGAHDIIKLLIDNGVDTS------ILPIPCIE 103

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039738591  179 QEMVELLLQAAANINALDNCKRSALIHAVRTQSKNMISLLLQQGANASLVDIYG 232
Cdd:PHA02874   104 KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNG 157
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 141-230 3.77e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.49  E-value: 3.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  141 VYNKDTTIAAKLLAFNAD-TEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDNCKRSALIHAVRTQSKNMISLLL 219
Cdd:PHA02874     9 IYSGDIEAIEKIIKNKGNcINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI 88

                           90
                   ....*....|.
gi 1039738591  220 QQGANASLVDI 230
Cdd:PHA02874    89 DNGVDTSILPI 99
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 32-120 7.13e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 40.65  E-value: 7.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591   32 MPVKRIHKAASvGDIPQVQKMLEfGDIDVNVTDRKKRTALHYACAHGQSEMVSLLLWYDCNIEARDREESTALIKATQRQ 111
Cdd:PTZ00322    82 LTVELCQLAAS-GDAVGARILLT-GGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENG 159


                   ....*....
gi 1039738591  112 HEICVKILL 120
Cdd:PTZ00322   160 FREVVQLLS 168
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 139-248 9.42e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.03  E-value: 9.42e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039738591  139 YTVYNKDTTIAAKLLAF----NADTEVKTKNGYTPLILAVLENKQEMVELLLQAAANINALDNCKRSAL-----IHAVRT 209
Cdd:PHA03100     4 YIVLTKSRIIKVKNIKYiimeDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLhylsnIKYNLT 83

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039738591  210 QSKNMISLLLQQGANASLVDIYGATAQSYAVFETFQVLS 248
Cdd:PHA03100    84 DVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYS 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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