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Conserved domains on  [gi|1039753239|ref|XP_017172885|]
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valine--tRNA ligase isoform X2 [Mus musculus]

Protein Classification

valine--tRNA ligase( domain architecture ID 1000888)

valine--tRNA ligase catalyzes the attachment of valine to tRNA(Val)

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PTZ00419 super family cl36560
valyl-tRNA synthetase-like protein; Provisional
1-895 0e+00

valyl-tRNA synthetase-like protein; Provisional


The actual alignment was detected with superfamily member PTZ00419:

Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 1291.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:PTZ00419   95 MKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDE 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTGRTLLPVPGYKEKVEFGVLVSFAYKVQGSDsDE 160
Cdd:PTZ00419  175 QRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYPLEDSG-QE 253
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLS-RSLPIVFDD-FVDMEFGTGAVKITPAHDQNDYEVGQRH 238
Cdd:PTZ00419  254 EIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRH 333
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 239 RLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQ 318
Cdd:PTZ00419  334 NLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAK 413
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 319 AASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITVHD-PAVPPGEDPdgryWVSGRTEAEAREK 397
Cdd:PTZ00419  414 RAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGpETDPSDEEP----WVVARSEEEALEK 489
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 398 AAREFGVSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPF 477
Cdd:PTZ00419  490 AKKKFGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPF 569
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 478 REVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHGVSLQGLYDQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGL 557
Cdd:PTZ00419  570 KTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDALRFGL 649
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 558 CAYTSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVP--SATSKPEGHESL--VDRWIRSRLTEAVRLSNEGF 633
Cdd:PTZ00419  650 LAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLpnSTLFKPNNVESLpwEDKWILHRLNVAIKEVTEGF 729
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 634 QAYDFPAITTAQYSFWLYELCDVYLECLKPVLN-GVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTPK 712
Cdd:PTZ00419  730 KEYDFSEATQATYNFWLYELCDVYLELIKPRLSkQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRK 809
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 713 APaSLCVTPYPEPSeCSWKDPEAEAALELALSITRAVRSLRADYNLT-RTRPDCFLEVADEATGALASAVSGYVQALASA 791
Cdd:PTZ00419  810 SE-SISIAKYPQPN-PGWNNEALDEEMKIIMSIVKSIRSLIATLGIPnKTKPDCYVTAKDAELIELIESAENLISTLAKI 887
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 792 G---VVAVLALGAPAPQGCAVAVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQE 868
Cdd:PTZ00419  888 GsvsVIPPIEEEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVRK 967
                         890       900
                  ....*....|....*....|....*..
gi 1039753239 869 ADEAKLQQTEAELRKVDEAIALFQKML 895
Cdd:PTZ00419  968 LNDEKIDELNEEIKQLEQAIEELKSLL 994
 
Name Accession Description Interval E-value
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
1-895 0e+00

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 1291.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:PTZ00419   95 MKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDE 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTGRTLLPVPGYKEKVEFGVLVSFAYKVQGSDsDE 160
Cdd:PTZ00419  175 QRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYPLEDSG-QE 253
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLS-RSLPIVFDD-FVDMEFGTGAVKITPAHDQNDYEVGQRH 238
Cdd:PTZ00419  254 EIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRH 333
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 239 RLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQ 318
Cdd:PTZ00419  334 NLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAK 413
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 319 AASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITVHD-PAVPPGEDPdgryWVSGRTEAEAREK 397
Cdd:PTZ00419  414 RAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGpETDPSDEEP----WVVARSEEEALEK 489
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 398 AAREFGVSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPF 477
Cdd:PTZ00419  490 AKKKFGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPF 569
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 478 REVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHGVSLQGLYDQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGL 557
Cdd:PTZ00419  570 KTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDALRFGL 649
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 558 CAYTSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVP--SATSKPEGHESL--VDRWIRSRLTEAVRLSNEGF 633
Cdd:PTZ00419  650 LAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLpnSTLFKPNNVESLpwEDKWILHRLNVAIKEVTEGF 729
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 634 QAYDFPAITTAQYSFWLYELCDVYLECLKPVLN-GVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTPK 712
Cdd:PTZ00419  730 KEYDFSEATQATYNFWLYELCDVYLELIKPRLSkQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRK 809
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 713 APaSLCVTPYPEPSeCSWKDPEAEAALELALSITRAVRSLRADYNLT-RTRPDCFLEVADEATGALASAVSGYVQALASA 791
Cdd:PTZ00419  810 SE-SISIAKYPQPN-PGWNNEALDEEMKIIMSIVKSIRSLIATLGIPnKTKPDCYVTAKDAELIELIESAENLISTLAKI 887
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 792 G---VVAVLALGAPAPQGCAVAVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQE 868
Cdd:PTZ00419  888 GsvsVIPPIEEEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVRK 967
                         890       900
                  ....*....|....*....|....*..
gi 1039753239 869 ADEAKLQQTEAELRKVDEAIALFQKML 895
Cdd:PTZ00419  968 LNDEKIDELNEEIKQLEQAIEELKSLL 994
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
1-889 0e+00

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 1083.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLwKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:COG0525    70 MQGYNTLWQPGTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDE 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDkkeltgrtllpvpgYKEKVefGVLVSFAYKVqgSDSDE 160
Cdd:COG0525   149 GLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVE--------------HEEVK--GHLWHIRYPL--ADGSG 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRL 240
Cdd:COG0525   211 YIVVATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 241 EAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAA 320
Cdd:COG0525   291 PMINILDEDGTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPA 370
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 321 SAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFitvhdpavppgeDPDGRYWVSgRTEAEAREKAar 400
Cdd:COG0525   371 IEAVEDGEIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWY------------CPDGEVYVA-RTEPEACAKA-- 435
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 401 efgvspDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREV 480
Cdd:COG0525   436 ------GSVNLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDV 509
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 481 YLHAIVRDAHGRKMSKSLGNVIDPLDVIhgvslqglyDQLlnsnldpsevekakegqkadfpagipecGTDALRFGLCAY 560
Cdd:COG0525   510 YIHGLVRDEQGRKMSKSKGNVIDPLDLI---------DKY----------------------------GADALRFTLAAL 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 561 TSQGRDINLDVNRILGYRHFCNKLWNATKFALrGLGKGFVPSATSKPEgHESLVDRWIRSRLTEAVRLSNEGFQAYDFPA 640
Cdd:COG0525   553 ASPGRDIKFDEERVEGYRNFANKLWNASRFVL-MNLEGFDPGLDPDPE-ELSLADRWILSRLNKTIAEVTEALEKYRFDE 630
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 641 ITTAQYSF-WlYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRtpKAPASLCV 719
Cdd:COG0525   631 AAQALYDFvW-NEFCDWYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPR--KEGESIML 707
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 720 TPYPEPSEcSWKDPEAEAALELALSITRAVRSLRADYNLT-RTRPDCFLEVADEATGALASAVSGYVQALASAGVVAVLA 798
Cdd:COG0525   708 APWPEADE-ELIDEEAEAEFEWLKEVISAIRNIRAEMNIPpSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILV 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 799 lgAPAPQGCAVAVASDrCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKLQQTE 878
Cdd:COG0525   787 --DEKPEGAASAVVGG-AEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAE 863
                         890
                  ....*....|.
gi 1039753239 879 AELRKVDEAIA 889
Cdd:COG0525   864 AKLEKLEEQLA 874
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
1-874 0e+00

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 884.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKErGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:TIGR00422  68 MKGYNVLWLPGTDHAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDE 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTGRtllpVPGYKEKVEFGvlvsfaykvqgsdSDE 160
Cdd:TIGR00422 147 GLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGK----LYYIRYPLANG-------------SKD 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRL 240
Cdd:TIGR00422 210 YLVVATTRPETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNL 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 241 EAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAA 320
Cdd:TIGR00422 290 EFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKA 369
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 321 SAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFItvhdpavppgeDPDGRYWVsGRTEAEAREKAAR 400
Cdd:TIGR00422 370 LEAAEEGEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYC-----------KECGEVYV-AKEEPLPDDKTNT 437
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 401 EFGVSpdkisLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREV 480
Cdd:TIGR00422 438 GPSVE-----LEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEV 512
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 481 YLHAIVRDAHGRKMSKSLGNVIDPLDVIHgvslqglydqllnsnldpsevekakegqkadfpagipECGTDALRFGLCAY 560
Cdd:TIGR00422 513 YIHGLVRDEQGRKMSKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASL 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 561 TSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKgfvPSATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDFPA 640
Cdd:TIGR00422 556 VTPGDDINFDWKRVESARNFLNKLWNASRFVLMNLSD---DLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAE 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 641 ITTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTpkapASLCVT 720
Cdd:TIGR00422 633 AAKALYEFIWNDFCDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGA----DSIMLQ 708
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 721 PYPEPSEcSWKDPEAEAALELALSITRAVRSLRADYNLTRTRPDCFLEVADEATGALA-SAVSGYVQALASAGVVAVLAl 799
Cdd:TIGR00422 709 SYPVVDA-EFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERlKLNAVDIKGAINFSEVEVVI- 786
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039753239 800 GAPaPQGCAVAVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKL 874
Cdd:TIGR00422 787 EKP-EVTEAVVELVPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKL 860
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
1-570 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 614.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:pfam00133  58 MKGYYVLWVPGWDHHGLPTEQVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDP 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTgrtllpvpgykekvefGVLVSFAYKVQGsDSDE 160
Cdd:pfam00133 138 ELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEYKDVK----------------GPSIHVAFPLAD-DEGA 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHP-------------------------------KDPRYQHLKGKCVVHPFLSRSLPIVFD 209
Cdd:pfam00133 201 SLVIWTTTPWTLPGNTAVAVNPefdyvitgegyilaeallkslykkgtdkkilEDFRGKELEGKEAIHPFVNREIPIITD 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 210 DFVDMEFGTGAVKITPAHDQNDYEVGQRHRLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPM 289
Cdd:pfam00133 281 DYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTH 360
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 290 VVPLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTrgDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITV 369
Cdd:pfam00133 361 SYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVE--KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKD 438
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 370 HDPAVPPGEdpdGRYWVSGRTEAEAREKA-AREFG--VSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQS-EDLSVFY 445
Cdd:pfam00133 439 TEEVVCRGE---LFELVAGRFEEEGSIKWlHREAKdkLGYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNtEEFKKFF 515
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 446 PGTLLETGHDILFFWVARMVMLGLKLTGKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHgvslqglydqllnsnl 525
Cdd:pfam00133 516 PADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID---------------- 579
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 1039753239 526 dpsevekakegqkadfpagipECGTDALRFGLCaYTSQGRDINLD 570
Cdd:pfam00133 580 ---------------------KYGADALRLWLA-NSDYGRDINLS 602
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
1-569 0e+00

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 542.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKERGlNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:cd00817    36 MKGYNVLWPPGTDHAGIATQVVVEKKLGIEGK-TRHDLGREEFLEKCWEWKEESGGKIREQLKRLGASVDWSREYFTMDP 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVdkkeltgrtllpvpgykekvefgvlvsfaykvqgsdsde 160
Cdd:cd00817   115 GLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV--------------------------------------- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 evvvattrietmlgdvavavhpkdpryqhlkgkcvvhpflsrslpivfddfvdmefgtgavkitpahdqndyevgqrhrl 240
Cdd:cd00817       --------------------------------------------------------------------------------
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 241 eaisimdskgalinvpppflglprfearkavlaalkerglfrgvkdnpmvvplCNRSKDVVEPLLRPQWYVRCGEMAQAA 320
Cdd:cd00817   156 -----------------------------------------------------CSRSGDVIEPLLKPQWFVKVKDLAKKA 182
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 321 SAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFItvhdpavppgedPDGRYWVSGRTEAEAREKAAR 400
Cdd:cd00817   183 LEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYC------------KDGGHWVVAREEDEAIDKAAP 250
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 401 EFGVSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREV 480
Cdd:cd00817   251 EACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEV 330
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 481 YLHAIVRDAHGRKMSKSLGNVIDPLDVihgvslqglydqllnsnldpsevekakegqkadfpagIPECGTDALRFGLCAY 560
Cdd:cd00817   331 YLHGLVRDEDGRKMSKSLGNVIDPLDV-------------------------------------IDGYGADALRFTLASA 373

                  ....*....
gi 1039753239 561 TSQGRDINL 569
Cdd:cd00817   374 ATQGRDINL 382
 
Name Accession Description Interval E-value
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
1-895 0e+00

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 1291.89  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:PTZ00419   95 MKGDETLWVPGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDE 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTGRTLLPVPGYKEKVEFGVLVSFAYKVQGSDsDE 160
Cdd:PTZ00419  175 QRSKAVKEAFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEKPTKITIPGYDKKVEVGVLWHFAYPLEDSG-QE 253
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLS-RSLPIVFDD-FVDMEFGTGAVKITPAHDQNDYEVGQRH 238
Cdd:PTZ00419  254 EIVVATTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRH 333
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 239 RLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQ 318
Cdd:PTZ00419  334 NLPFINIFTLDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAK 413
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 319 AASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITVHD-PAVPPGEDPdgryWVSGRTEAEAREK 397
Cdd:PTZ00419  414 RAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYRVISKGpETDPSDEEP----WVVARSEEEALEK 489
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 398 AAREFGVSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPF 477
Cdd:PTZ00419  490 AKKKFGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPF 569
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 478 REVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHGVSLQGLYDQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDALRFGL 557
Cdd:PTZ00419  570 KTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKLYEGNLPEKEIKRAIELQKKEFPNGIPECGTDALRFGL 649
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 558 CAYTSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVP--SATSKPEGHESL--VDRWIRSRLTEAVRLSNEGF 633
Cdd:PTZ00419  650 LAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLpnSTLFKPNNVESLpwEDKWILHRLNVAIKEVTEGF 729
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 634 QAYDFPAITTAQYSFWLYELCDVYLECLKPVLN-GVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTPK 712
Cdd:PTZ00419  730 KEYDFSEATQATYNFWLYELCDVYLELIKPRLSkQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPNYLRK 809
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 713 APaSLCVTPYPEPSeCSWKDPEAEAALELALSITRAVRSLRADYNLT-RTRPDCFLEVADEATGALASAVSGYVQALASA 791
Cdd:PTZ00419  810 SE-SISIAKYPQPN-PGWNNEALDEEMKIIMSIVKSIRSLIATLGIPnKTKPDCYVTAKDAELIELIESAENLISTLAKI 887
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 792 G---VVAVLALGAPAPQGCAVAVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQE 868
Cdd:PTZ00419  888 GsvsVIPPIEEEAEVPKGCGFDVVDNKVIIYLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVRK 967
                         890       900
                  ....*....|....*....|....*..
gi 1039753239 869 ADEAKLQQTEAELRKVDEAIALFQKML 895
Cdd:PTZ00419  968 LNDEKIDELNEEIKQLEQAIEELKSLL 994
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ...
1-889 0e+00

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440291 [Multi-domain]  Cd Length: 877  Bit Score: 1083.54  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLwKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:COG0525    70 MQGYNTLWQPGTDHAGIATQAVVERQL-AEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDE 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDkkeltgrtllpvpgYKEKVefGVLVSFAYKVqgSDSDE 160
Cdd:COG0525   149 GLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLKTALSDLEVE--------------HEEVK--GHLWHIRYPL--ADGSG 210
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRL 240
Cdd:COG0525   211 YIVVATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 241 EAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAA 320
Cdd:COG0525   291 PMINILDEDGTINENAGKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPA 370
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 321 SAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFitvhdpavppgeDPDGRYWVSgRTEAEAREKAar 400
Cdd:COG0525   371 IEAVEDGEIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWY------------CPDGEVYVA-RTEPEACAKA-- 435
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 401 efgvspDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREV 480
Cdd:COG0525   436 ------GSVNLTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTGEVPFKDV 509
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 481 YLHAIVRDAHGRKMSKSLGNVIDPLDVIhgvslqglyDQLlnsnldpsevekakegqkadfpagipecGTDALRFGLCAY 560
Cdd:COG0525   510 YIHGLVRDEQGRKMSKSKGNVIDPLDLI---------DKY----------------------------GADALRFTLAAL 552
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 561 TSQGRDINLDVNRILGYRHFCNKLWNATKFALrGLGKGFVPSATSKPEgHESLVDRWIRSRLTEAVRLSNEGFQAYDFPA 640
Cdd:COG0525   553 ASPGRDIKFDEERVEGYRNFANKLWNASRFVL-MNLEGFDPGLDPDPE-ELSLADRWILSRLNKTIAEVTEALEKYRFDE 630
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 641 ITTAQYSF-WlYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRtpKAPASLCV 719
Cdd:COG0525   631 AAQALYDFvW-NEFCDWYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPPR--KEGESIML 707
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 720 TPYPEPSEcSWKDPEAEAALELALSITRAVRSLRADYNLT-RTRPDCFLEVADEATGALASAVSGYVQALASAGVVAVLA 798
Cdd:COG0525   708 APWPEADE-ELIDEEAEAEFEWLKEVISAIRNIRAEMNIPpSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILV 786
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 799 lgAPAPQGCAVAVASDrCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKLQQTE 878
Cdd:COG0525   787 --DEKPEGAASAVVGG-AEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAE 863
                         890
                  ....*....|.
gi 1039753239 879 AELRKVDEAIA 889
Cdd:COG0525   864 AKLEKLEEQLA 874
valS PRK05729
valyl-tRNA synthetase; Reviewed
1-893 0e+00

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 1050.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKErGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:PRK05729   71 MQGYNTLWLPGTDHAGIATQMVVERQLAAE-GKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDE 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDkkeltgrtllpvpgYKEkVEfGVLVSFAYKVqgSDSDE 160
Cdd:PRK05729  150 GLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEVE--------------YKE-VK-GKLWHIRYPL--ADGSD 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRL 240
Cdd:PRK05729  212 YLVVATTRPETMLGDTAVAVNPEDERYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNL 291
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 241 EAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAA 320
Cdd:PRK05729  292 PMINIMDEDGTINENPGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPA 371
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 321 SAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFitvhdpavppgeDPDGRYWVsGRTEAEAREKAAr 400
Cdd:PRK05729  372 LEAVENGEIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWY------------DEDGEVYV-GREEPEAREKAL- 437
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 401 efgvspdkisLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREV 480
Cdd:PRK05729  438 ----------LTQDEDVLDTWFSSALWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTGQVPFKDV 507
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 481 YLHAIVRDAHGRKMSKSLGNVIDPLDVIhgvslqglyDQLlnsnldpsevekakegqkadfpagipecGTDALRFGLCAY 560
Cdd:PRK05729  508 YIHGLVRDEQGRKMSKSKGNVIDPLDLI---------DKY----------------------------GADALRFTLAAL 550
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 561 TSQGRDINLDVNRILGYRHFCNKLWNATKFALrgLGKGFVPSATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDFPA 640
Cdd:PRK05729  551 ASPGRDIRFDEERVEGYRNFANKLWNASRFVL--MNLEGADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDE 628
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 641 ITTAQYSFWLYELCDVYLECLKPVLNGVDQVAaecARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTPKapASLCVT 720
Cdd:PRK05729  629 AARALYEFIWNEFCDWYLELAKPVLQEAAKRA---TRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGIE--ESIMLA 703
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 721 PYPEPSECswKDPEAEAALELALSITRAVRSLRADYNLT-RTRPDCFLEVADEATGALASAVSGYVQALASAGVVAVLAL 799
Cdd:PRK05729  704 PWPEADEA--IDEAAEAEFEWLKELITAIRNIRAEMNIPpSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILAD 781
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 800 GAPAPQGCAVAVASDrCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKLQQTEA 879
Cdd:PRK05729  782 DEEAPEGAASAVVGG-AELFLPLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEE 860
                         890
                  ....*....|....
gi 1039753239 880 ELRKVDEAIALFQK 893
Cdd:PRK05729  861 KLAKLKERLARLKA 874
PLN02381 PLN02381
valyl-tRNA synthetase
1-887 0e+00

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 1037.16  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239    1 MRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:PLN02381   163 MSGYNALWVPGVDHAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDE 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTGRTLLPVPGYKEKVEFGVLVSFAYKVQGSDSde 160
Cdd:PLN02381   243 QRSKAVTEAFVRLYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKERTLLKVPGYDKPVEFGVLTSFAYPLEGGLG-- 320
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLSRSLPIVFD-DFVDMEFGTGAVKITPAHDQNDYEVGQRHR 239
Cdd:PLN02381   321 EIVVATTRIETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHN 400
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  240 LEAISIMDSKGAL-INVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQ 318
Cdd:PLN02381   401 LEFINIFTDDGKInSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAK 480
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  319 AASAAVTRGD---LRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITVHDPAvppgEDPDGRY---WVSGRTEA 392
Cdd:PLN02381   481 QALDAAIDGEnkkLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYVTLEDDQ----LKELGSYndhWVVARNES 556
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  393 EAREKAAREFgvSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLT 472
Cdd:PLN02381   557 DALLEASQKF--PGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLG 634
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  473 GKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHGVSLQGLYDQLLNSNLDPSEVEKAKEGQKADFPAGIPECGTDA 552
Cdd:PLN02381   635 GDVPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKDFPNGIAECGTDA 714
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  553 LRFGLCAYTSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVPSATSKPEGHESLVdRWIRSRLTEAVRLSNEG 632
Cdd:PLN02381   715 LRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSC-KWILSVLNKAISKTVSS 793
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  633 FQAYDFPAITTAQYSFWLYELCDVYLECLKPVLNGVDQ---VAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPR- 708
Cdd:PLN02381   794 LDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNPefaSERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQp 873
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  709 RTPKAPASLCVTPYPEPSEcSWKDPEAEAALELALSITRAVRSLRADYNLTRT--RPDCFLEVADEATGALASAVSGYVQ 786
Cdd:PLN02381   874 KDHTRKDSIMISEYPSAVE-AWTNEKVEYEMDLVLSTVKCLRSLRAEVLEKQKneRLPAFALCRNQEIAAIIKSHQLEIL 952
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  787 ALASAGVVAVLALGAPA-PQGCAVAVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLE 865
Cdd:PLN02381   953 TLANLSSLKVLLSENDApPAGCAFENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKEKVPAN 1032
                          890       900
                   ....*....|....*....|..
gi 1039753239  866 VQEADEAKLQQTEAELRKVDEA 887
Cdd:PLN02381  1033 IQEEDARKLTKLLQELEFFEKE 1054
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
1-874 0e+00

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 884.01  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKErGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:TIGR00422  68 MKGYNVLWLPGTDHAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDE 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTGRtllpVPGYKEKVEFGvlvsfaykvqgsdSDE 160
Cdd:TIGR00422 147 GLSKAVKEAFVRLYEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGK----LYYIRYPLANG-------------SKD 209
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRL 240
Cdd:TIGR00422 210 YLVVATTRPETMFGDTAVAVHPEDERYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNL 289
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 241 EAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQAA 320
Cdd:TIGR00422 290 EFINILDEDGLLNENAGKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKA 369
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 321 SAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFItvhdpavppgeDPDGRYWVsGRTEAEAREKAAR 400
Cdd:TIGR00422 370 LEAAEEGEIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYC-----------KECGEVYV-AKEEPLPDDKTNT 437
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 401 EFGVSpdkisLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREV 480
Cdd:TIGR00422 438 GPSVE-----LEQDTDVLDTWFSSSLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEV 512
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 481 YLHAIVRDAHGRKMSKSLGNVIDPLDVIHgvslqglydqllnsnldpsevekakegqkadfpagipECGTDALRFGLCAY 560
Cdd:TIGR00422 513 YIHGLVRDEQGRKMSKSLGNVIDPLDVIE-------------------------------------KYGADALRFTLASL 555
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 561 TSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKgfvPSATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDFPA 640
Cdd:TIGR00422 556 VTPGDDINFDWKRVESARNFLNKLWNASRFVLMNLSD---DLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAE 632
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 641 ITTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTpkapASLCVT 720
Cdd:TIGR00422 633 AAKALYEFIWNDFCDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGA----DSIMLQ 708
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 721 PYPEPSEcSWKDPEAEAALELALSITRAVRSLRADYNLTRTRPDCFLEVADEATGALA-SAVSGYVQALASAGVVAVLAl 799
Cdd:TIGR00422 709 SYPVVDA-EFVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERlKLNAVDIKGAINFSEVEVVI- 786
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039753239 800 GAPaPQGCAVAVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKL 874
Cdd:TIGR00422 787 EKP-EVTEAVVELVPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKL 860
valS PRK14900
valyl-tRNA synthetase; Provisional
1-890 0e+00

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 788.42  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239    1 MRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:PRK14900    83 MSGFNTLWLPGTDHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDE 162
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKEltgrtllpvpgykekVEFGVLVSFAYKVqgSDSDE 160
Cdd:PRK14900   163 GLSRAVREVFVRLHEEGLIYREKKLINWCPDCRTALSDLEVEHEE---------------AHQGELWSFAYPL--ADGSG 225
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLSRSLPIVFD-DFVDMEFGTGAVKITPAHDQNDYEVGQRHR 239
Cdd:PRK14900   226 EIVVATTRPETMLGDTAVAVHPLDPRYMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHG 305
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  240 LEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQA 319
Cdd:PRK14900   306 LEMITVIGPDGRMTAEAGPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARP 385
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  320 ASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFItvhdpavppgedPDGRYWVSGRTEAEAREKAA 399
Cdd:PRK14900   386 AIEAVEQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYC------------PDGHVTVARETPEACSTCGK 453
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  400 REFgvspdkislQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFRE 479
Cdd:PRK14900   454 AEL---------RQDEDVLDTWFSSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRT 524
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  480 VYLHAIVRDAHGRKMSKSLGNVIDPLDVihgvslqglydqllnsnldpsevekakegqkadfpagIPECGTDALRFGLCA 559
Cdd:PRK14900   525 VYLHPMVRDEKGQKMSKTKGNVIDPLVI-------------------------------------TEQYGADALRFTLAA 567
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  560 YTSQGRDINLDVNRILGYRHFCNKLWNATKFALRGLGkGFVPSATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDFP 639
Cdd:PRK14900   568 LTAQGRDIKLAKERIEGYRAFANKLWNASRFALMNLS-GYQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFN 646
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  640 AITTAQYSFWLYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLP--RRTPKAPASL 717
Cdd:PRK14900   647 DAANAVYAFVWHELCDWYIELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRaqVGASAWADSV 726
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  718 CVTPYPEPSECswkDPEAEAALELALSITRAVRSLRADYNLT-----RTRPDCFLEVADEATGALASAVS-GYVQALASA 791
Cdd:PRK14900   727 LAAEYPRKGEA---DEAAEAAFRPVLGIIDAVRNIRGEMGIPwkvklGAQAPVEIAVADPALRDLLQAGElARVHRVAGV 803
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  792 GVVAVLALGAPAPQGCAVAVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQEADE 871
Cdd:PRK14900   804 EGSRLVVAAATAPAPQSAVGVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDR 883
                          890
                   ....*....|....*....
gi 1039753239  872 AKLQQTEAELRKVDEAIAL 890
Cdd:PRK14900   884 ARAEELREKRGKLEAHRAM 902
PLN02943 PLN02943
aminoacyl-tRNA ligase
1-894 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 215509 [Multi-domain]  Cd Length: 958  Bit Score: 655.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKErGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:PLN02943  123 MKGRPTLWIPGTDHAGIATQLVVEKMLASE-GIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDE 201
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKEltgrtllpvpgykekvEFGVLVSFAYKVQGSdSDE 160
Cdd:PLN02943  202 QLSRAVVEAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEVEYSE----------------EPGTLYYIKYRVAGG-SED 264
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPF-LSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHR 239
Cdd:PLN02943  265 FLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMtYGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLG 344
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 240 LEAISIMDSKGALINVPppflGLPRFEARKAVLAALKERGLfrGVKDNP--MVVPLCNRSKDVVEPLLRPQWYVRCGEMA 317
Cdd:PLN02943  345 LPILNVMNKDGTLNEVA----GLYWFEAREKLWSDLEETGL--AVKKEPhtLRVPRSQRGGEVIEPLVSKQWFVTMEPLA 418
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 318 QAASAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITvhdpavppGEDPDGRYWVSgRTEAEAREK 397
Cdd:PLN02943  419 EKALKAVENGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIPVWYIV--------GKDCEEDYIVA-RSAEEALEK 489
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 398 AAREFGVSpdkISLQQDEDVLDTWFSSGLFPFSIFGWPNQS-EDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLP 476
Cdd:PLN02943  490 AREKYGKD---VEIYQDPDVLDTWFSSALWPFSTLGWPDVSaEDFKKFYPTTVLETGHDILFFWVARMVMMGIEFTGTVP 566
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 477 FREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHgvslqglydqllnsnldpsevekakegqkadfpagipECGTDALRFG 556
Cdd:PLN02943  567 FSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIK-------------------------------------EFGTDALRFT 609
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 557 LCAYTSqGRDINLDVNRILGYRHFCNKLWNATKFALRGLGKGFVPSA-----TSKPEGHESLV-----DRWIRSRLTEAV 626
Cdd:PLN02943  610 LALGTA-GQDLNLSTERLTSNKAFTNKLWNAGKFVLQNLPSQSDTSAwehilACKFDKEESLLslplpECWVVSKLHELI 688
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 627 RLSNEGFQAYDFPAITTAQYSFWLYELCDVYLECLKPVLNGV-DQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQR 705
Cdd:PLN02943  689 DSVTTSYDKYFFGDVGREIYDFFWSDFADWYIEASKTRLYHSgDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQA 768
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 706 LPRRTpkapASLCVTPYPEPSECswKDPEAEAALELALSITRAVRSLRADYNLTRTRPDCFLEVADEATGALASAVSGYV 785
Cdd:PLN02943  769 LPYRK----EALIVSPWPQTSLP--KDLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVASAEVIEYISKEKEVL 842
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 786 QALASAGVVAVLALGAP---APQGCAVaVASDRCSIHLQLQGLVDPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKV 862
Cdd:PLN02943  843 ALLSRLDLQNVHFTDSPpgdANQSVHL-VASEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKA 921
                         890       900       910
                  ....*....|....*....|....*....|..
gi 1039753239 863 PLEVQEADEAKLQQTEAELRKVDEAIALFQKM 894
Cdd:PLN02943  922 PEDVVRGVREKAAEAEEKIKLTKNRLAFLKST 953
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
1-570 0e+00

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 459685 [Multi-domain]  Cd Length: 602  Bit Score: 614.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKERGLNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:pfam00133  58 MKGYYVLWVPGWDHHGLPTEQVVEKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDP 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTgrtllpvpgykekvefGVLVSFAYKVQGsDSDE 160
Cdd:pfam00133 138 ELEAAVWEVFVRLHDKGLIYRGKKLVNWSPALNTALSNLEVEYKDVK----------------GPSIHVAFPLAD-DEGA 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 EVVVATTRIETMLGDVAVAVHP-------------------------------KDPRYQHLKGKCVVHPFLSRSLPIVFD 209
Cdd:pfam00133 201 SLVIWTTTPWTLPGNTAVAVNPefdyvitgegyilaeallkslykkgtdkkilEDFRGKELEGKEAIHPFVNREIPIITD 280
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 210 DFVDMEFGTGAVKITPAHDQNDYEVGQRHRLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPM 289
Cdd:pfam00133 281 DYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDDGTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTH 360
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 290 VVPLCNRSKDVVEPLLRPQWYVRCGEMAQAASAAVTrgDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFITV 369
Cdd:pfam00133 361 SYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVE--KVQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKD 438
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 370 HDPAVPPGEdpdGRYWVSGRTEAEAREKA-AREFG--VSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQS-EDLSVFY 445
Cdd:pfam00133 439 TEEVVCRGE---LFELVAGRFEEEGSIKWlHREAKdkLGYGKGTLEQDEDVLDTWFSSGSWPFSTLGWPFVNtEEFKKFF 515
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 446 PGTLLETGHDILFFWVARMVMLGLKLTGKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHgvslqglydqllnsnl 525
Cdd:pfam00133 516 PADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID---------------- 579
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 1039753239 526 dpsevekakegqkadfpagipECGTDALRFGLCaYTSQGRDINLD 570
Cdd:pfam00133 580 ---------------------KYGADALRLWLA-NSDYGRDINLS 602
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
1-569 0e+00

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 542.99  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLWKERGlNRHQLGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDP 80
Cdd:cd00817    36 MKGYNVLWPPGTDHAGIATQVVVEKKLGIEGK-TRHDLGREEFLEKCWEWKEESGGKIREQLKRLGASVDWSREYFTMDP 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  81 KLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVdkkeltgrtllpvpgykekvefgvlvsfaykvqgsdsde 160
Cdd:cd00817   115 GLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV--------------------------------------- 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 161 evvvattrietmlgdvavavhpkdpryqhlkgkcvvhpflsrslpivfddfvdmefgtgavkitpahdqndyevgqrhrl 240
Cdd:cd00817       --------------------------------------------------------------------------------
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 241 eaisimdskgalinvpppflglprfearkavlaalkerglfrgvkdnpmvvplCNRSKDVVEPLLRPQWYVRCGEMAQAA 320
Cdd:cd00817   156 -----------------------------------------------------CSRSGDVIEPLLKPQWFVKVKDLAKKA 182
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 321 SAAVTRGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYFItvhdpavppgedPDGRYWVSGRTEAEAREKAAR 400
Cdd:cd00817   183 LEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYC------------KDGGHWVVAREEDEAIDKAAP 250
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 401 EFGVSPDKISLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREV 480
Cdd:cd00817   251 EACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGKLPFKEV 330
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 481 YLHAIVRDAHGRKMSKSLGNVIDPLDVihgvslqglydqllnsnldpsevekakegqkadfpagIPECGTDALRFGLCAY 560
Cdd:cd00817   331 YLHGLVRDEDGRKMSKSLGNVIDPLDV-------------------------------------IDGYGADALRFTLASA 373

                  ....*....
gi 1039753239 561 TSQGRDINL 569
Cdd:cd00817   374 ATQGRDINL 382
valS PRK13208
valyl-tRNA synthetase; Reviewed
1-805 4.03e-120

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 383.77  E-value: 4.03e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   1 MRGETTLWNPGCDHAGIATQVVVEKKLwkerGLNRHQLGREAFLE--EVWKWKAEKGDRiyHQLKKLGSSLDWDRACFTM 78
Cdd:PRK13208   73 MRGYNVFFPQGWDDNGLPTERKVEKYY----GIRKDDISREEFIElcRELTDEDEKKFR--ELWRRLGLSVDWSLEYQTI 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  79 DPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKELTGRtllpvpgykekvefgvLVSFAYKVQGsds 158
Cdd:PRK13208  147 SPEYRRISQKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGK----------------LNYIKFPVED--- 207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 159 DEEVVVATTRIETMLGDVAVAVHPKDPRYQHLKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRH 238
Cdd:PRK13208  208 GEEIEIATTRPELLPACVAVVVHPDDERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWREL 287
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 239 RLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGLFRGVKDNPMVVPLCNRSKDVVEPLLRPQWYVRCGEMAQ 318
Cdd:PRK13208  288 NLPTRIIIDEDGRMTEAAGKLAGLTIEEARKKIVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKE 367
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 319 AAsaaVTRGD-LRILPEAHQRTWHSWMDNIR-DWCISRQ--------LWW----GHRIPA----YFItvhDPA--VPPGE 378
Cdd:PRK13208  368 EL---LERGKeINWYPEHMRVRLENWIEGLNwDWCISRQryfgtpipVWYckdcGHPILPdeedLPV---DPTkdEPPGY 441
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 379 DPDGRywvsGRTEAEArekaarefgvspdkislqqDEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILF 458
Cdd:PRK13208  442 KCPQC----GSPGFEG-------------------ETDVMDTWATSSITPLIVTGWERDEDLFEKVFPMDLRPQGHDIIR 498
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 459 FW----VARMVMLglklTGKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIhgvslqglydqllnsnldpsevekak 534
Cdd:PRK13208  499 TWlfytILRAYLL----TGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELL-------------------------- 548
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 535 egqkadfpagiPECGTDALRFGLcAYTSQGRDINLDVNRILGYRHFCNKLWNATKFALrGLGKGFVPSATSKPEghesLV 614
Cdd:PRK13208  549 -----------EKYGADAVRYWA-ASARLGSDTPFDEKQVKIGRRLLTKLWNASRFVL-HFSADPEPDKAEVLE----PL 611
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 615 DRWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFWLYELCDVYLECLKPVL-NGVDQVAAECARQTLYTCLDVGLRLLSP 693
Cdd:PRK13208  612 DRWILAKLAKVVEKATEALENYDFAKALEEIESFFWHVFCDDYLELVKSRAyGEDEEEEQKSARYTLYTVLDTLLRLLAP 691
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 694 FMPFVTEELFQRLPRRtpkapaSLCVTPYPEPSEcSWKDPEAEAALELALSITRAVRSLRADYNLTRTRPdcfLEVADEA 773
Cdd:PRK13208  692 FLPFITEEVWSWLYGG------SVHRASWPEPDE-ELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAP---LKKVEVY 761
                         810       820       830
                  ....*....|....*....|....*....|..
gi 1039753239 774 TGALASAVSGYVQALASAGVVAVLALGAPAPQ 805
Cdd:PRK13208  762 GPADLELLEAAEEDLKAAGNIEELELVEGDPE 793
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ...
23-780 7.88e-80

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439830 [Multi-domain]  Cd Length: 931  Bit Score: 277.73  E-value: 7.88e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  23 VEKKLwkerGLNR---HQLGREAFLEE----VWKWKAEKGDriyhQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHE 95
Cdd:COG0060   103 VEKEL----GIKKkdiEKVGIAEFREKcreyALKYVDEQRE----DFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYE 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  96 EGVIYRSTRLVNWSCTLNSAISDIEVdkkeltgrtllpvpGYKEKVEFGVLVSFayKVQGS-----DSDEEVVVATTRIE 170
Cdd:COG0060   175 KGLLYKGLKPVPWCPRCGTALAEAEV--------------EYKDVTSPSIYVKF--PVKDEkalllLEDAYLVIWTTTPW 238
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 171 TMLGDVAVAVHP---------KDPRY----------------------------QHLKGKCVVHPFL-----SRSLPIVF 208
Cdd:COG0060   239 TLPANLAVAVHPdidyvlvevTGGERlilaealveavlkelgiedyevlatfkgAELEGLRYEHPFYyvvgyDRAHPVIL 318
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 209 DDFVDMEFGTGAVKITPAHDQNDYEVGQRHRLEAISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERG-LFRGVKdn 287
Cdd:COG0060   319 GDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGaLLAREK-- 396
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 288 pmVV---PLCNRSKdvvEPLL---RPQWYVRCGEMAQAASAAVTR-------GDLRIlpeahqrtwHSWMDNIRDWCISR 354
Cdd:COG0060   397 --IThsyPHCWRCK---TPLIyraTPQWFISMDKLRDRALEAIEKvnwipewGEGRF---------GNMLENRPDWCISR 462
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 355 QLWWGHRIPAYfitVHDPavpPGEDPDGRYWVSGRTEAEAREKAAREFGVSPDKISLQQD-------------EDVLDTW 421
Cdd:COG0060   463 QRYWGVPIPIW---VCED---CGELHRTEEVIGSVAELLEEEGADAWFELDLHRPFLDETlkcpkcggtmrrvPDVLDVW 536
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 422 FSSGLFPFSIFgwpNQSEDLSvfYPGTL-LEtGHD---------ILffwvarmvmLGLKLTGKLPFREVYLHAIVRDAHG 491
Cdd:COG0060   537 FDSGSMHFAVL---ENREELH--FPADFyLE-GSDqtrgwfyssLL---------TSTALFGRAPYKNVLTHGFVLDEDG 601
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 492 RKMSKSLGNVIDPLDVIhgvslqglyDQLlnsnldpsevekakegqkadfpagipecGTDALRFgLCAYTSQGRDINLDV 571
Cdd:COG0060   602 RKMSKSLGNVVDPQEVI---------DKY----------------------------GADILRL-WVASSDYWGDLRFSD 643
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 572 NRILGYRHFCNKLWNATKFALRGLGkGFVPSATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDFPAITTAqysfwLY 651
Cdd:COG0060   644 EILKEVRDVYRRLRNTYRFLLANLD-DFDPAEDAVPYEDLPELDRWILSRLNELIKEVTEAYDNYDFHRAYRA-----LH 717
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 652 ELCDV-----YLECLKPVL--NGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRrtpKAPASLCVTPYPE 724
Cdd:COG0060   718 NFCVEdlsnwYLDISKDRLytEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQNLPG---EAEESVHLADWPE 794
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039753239 725 PSEcSWKDPeaeaalelalsitravrSLRADYNLTRtrpdcflEVADEATGALASA 780
Cdd:COG0060   795 VDE-ELIDE-----------------ELEAKWDLVR-------EVRSAVLKALEAA 825
Anticodon_Ia_Val cd07962
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ...
569-706 5.00e-61

Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.


Pssm-ID: 153416 [Multi-domain]  Cd Length: 135  Bit Score: 203.17  E-value: 5.00e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 569 LDVNRILGYRHFCNKLWNATKFALRGLGKGFVPSATSKPEgheSLVDRWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSF 648
Cdd:cd07962     1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPESL---SLADRWILSRLNKTVEEVTEALENYRFSEAATALYEF 77
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039753239 649 WLYELCDVYLECLKPVLNGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRL 706
Cdd:cd07962    78 FWNDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
PLN02843 PLN02843
isoleucyl-tRNA synthetase
61-730 3.76e-39

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 157.24  E-value: 3.76e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  61 QLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKEltgrtllpvpGYKEK 140
Cdd:PLN02843  124 SFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIYRGRKPVHWSPSSRTALAEAELEYPE----------GHVSK 193
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 141 VEFGVL-VSFAYKVQGSDSDE-----EVVVATTRIETMLGDVAVAVHPK----------------------DPRYQHL-- 190
Cdd:PLN02843  194 SIYVAFpVVSPSETSPEELEEflpglSLAIWTTTPWTMPANAAVAVNDKlqysvvevqsfsedestsggnkKKRPGNVlk 273
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 191 ---KGKCVV---------------------------------HPFLSRSLPIVFD-DFVDMEFGTGAVKITPAHDQNDYE 233
Cdd:PLN02843  274 eqqKLFLIVatdlvpaleakwgvklvvlktfpgsdlegcryiHPLYNRESPVVIGgDYITTESGTGLVHTAPGHGQEDYI 353
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 234 VGQRHRLEAISIMDSKGALINVPPPFLGLPRF-EARKAVLAALKERGLFrgVKDNPMV--VPLCNRSKdvvEP-LLRP-- 307
Cdd:PLN02843  354 TGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLgEGNAAVVEALDEAGSL--LMEEAYGhkYPYDWRTK---KPtIFRAte 428
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 308 QWYVRCGEMAQAASAAVtrGDLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPAYF------------ITVHDPAVP 375
Cdd:PLN02843  429 QWFASVEGFRQAALDAI--DKVKWIPAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFYhvetkeplmneeTIAHVKSIV 506
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 376 PGEDPDGrYW---VSGRTEAEAREKAARefgvspdkisLQQDEDVLDTWFSSGlfpFSIFGWPNQSEDLSvfYPGTLLET 452
Cdd:PLN02843  507 AQKGSDA-WWymdVEDLLPEKYRDKASD----------YEKGTDTMDVWFDSG---SSWAGVLGSREGLS--YPADLYLE 570
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 453 GHDILFFWVARMVMLGLKLTGKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHGvslqglydqllnsnldpsevek 532
Cdd:PLN02843  571 GSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEG---------------------- 628
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 533 aKEGQKADfpagiPECGTDALRFGLCA--YTSqgrDINLDVNrIL-----GYRhfcnKLWNATKFALRGLGKgFVPSATS 605
Cdd:PLN02843  629 -GKNQKQE-----PAYGADVLRLWVASvdYTG---DVLIGPQ-ILkqmsdIYR----KLRGTLRYLLGNLHD-WKPDNAV 693
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 606 KpegHESL--VDRWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFWLYELCDVYLECLKPVL--NGVDQVAAECARQTLY 681
Cdd:PLN02843  694 P---YEDLpsIDKYALFQLENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDRLyvGGTTSFTRRSCQTVLA 770
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039753239 682 TCLDVGLRLLSPFMPFVTEELFQRLPRRTPKAPA-SLCVTPYPEPSEcSW 730
Cdd:PLN02843  771 AHLLSLLRAIAPILPHLAEDAWQNLPFQEDGSAAeSVFEAGWPTPNE-EW 819
PLN02882 PLN02882
aminoacyl-tRNA ligase
63-727 3.20e-38

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 154.50  E-value: 3.20e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   63 KKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDKKeltgrtllpvpgYKEKVE 142
Cdd:PLN02882   135 TRTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAGLN------------YKDVSD 202
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  143 FGVLVSFAykVQGsDSDEEVVVA-TTRIETMLGDVAVAVHPK------------------DPRYQHL--------KGK-- 193
Cdd:PLN02882   203 PAVMVSFP--IVG-DPDNASFVAwTTTPWTLPSNLALCVNPNftyvkvrnkytgkvyivaESRLSALptakpkskKGSkp 279
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  194 -------CVVHPFLSRSL------PI--------------VFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRL-----E 241
Cdd:PLN02882   280 enaaegyEVLAKVPGSSLvgkkyePLfdyfsefsdtafrvVADDYVTDDSGTGVVHCAPAFGEDDYRVCLANGIiekggN 359
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  242 AISIMDSKGALINVPPPFLGLPRFEARKAVLAALKERGlfRGVKDNPMV--VPLCNRSKdvvEPLLR---PQWYVRCGEM 316
Cdd:PLN02882   360 LPVPVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKG--RLVKSGSIThsYPFCWRSD---TPLIYravPSWFVKVEEI 434
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  317 AQaasaavtrgdlRILPEAHQRTW----------HSWMDNIRDWCISRQLWWGHRIPAYFitvhdpavppgeDPDGRYWV 386
Cdd:PLN02882   435 KD-----------RLLENNKQTYWvpdyvkekrfHNWLENARDWAVSRSRFWGTPLPIWI------------SDDGEEVV 491
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  387 SGRTEAEARE---------------------KAAREFGVspdkisLQQDEDVLDTWFSSGLFPFSIFGWPNQSEDLsvF- 444
Cdd:PLN02882   492 VIGSIAELEKlsgvkvtdlhrhfidhitipsSRGPEFGV------LRRVDDVFDCWFESGSMPYAYIHYPFENKEL--Fe 563
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  445 --YPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHGVSLQGLYDQLLN 522
Cdd:PLN02882   564 knFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLIN 643
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  523 SnldpsevekakegqkadfpagiPECGTDALRFGLCAYTSQGRDINLD-VNrilGYRHFcnkLWNATKFALRGLGKgFVP 601
Cdd:PLN02882   644 S----------------------PVVRAEPLRFKEEGVFGVVKDVFLPwYN---AYRFL---VQNAKRLEVEGGAP-FVP 694
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  602 SATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFwLYELCDVYLECLKPVLNGVDQVA-AECARQTL 680
Cdd:PLN02882   695 LDLAKLQNSANVLDRWINSATQSLVKFVREEMGAYRLYTVVPYLVKF-IDNLTNIYVRFNRKRLKGRTGEEdCRTALSTL 773
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*..
gi 1039753239  681 YTCLDVGLRLLSPFMPFVTEELFQRLPRRTPKAPASLCVTPYPEPSE 727
Cdd:PLN02882   774 YNVLLTSCKVMAPFTPFFTEVLYQNLRKVLPGSEESIHYCSFPQVDE 820
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
307-508 6.99e-37

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 141.40  E-value: 6.99e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 307 PQWYVRCGEMAQAASAAVTRGDlrILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIPayfitvhdpavppgedpdgrywv 386
Cdd:cd00668   140 EQWFFDMPKFKEKLLKALRRGK--IVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP----------------------- 194
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 387 sgrteaearekaarefgvspdkislqqdEDVLDTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVM 466
Cdd:cd00668   195 ----------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRGWANFWIT 246
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 1039753239 467 LGLKLTGKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVI 508
Cdd:cd00668   247 MLVALFGEIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV 288
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
263-524 1.04e-29

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 121.19  E-value: 1.04e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 263 PRFEArkAVLAALKE---RGL-FRGVKdnPMVVPLCNRSKdvvepllrPQWYVRCGEMAQAASAAVTRgdLRILPEAHQR 338
Cdd:cd00818   115 PEYME--SVWWVFKQlheKGLlYRGYK--VVPWPLIYRAT--------PQWFIRVTKIKDRLLEANDK--VNWIPEWVKN 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 339 TWHSWMDNIRDWCISRQLWWGHRIPAyfitvhdpavppgedpdgryWVSgrteaearekaarefgVSPDKISLQQDEDVL 418
Cdd:cd00818   181 RFGNWLENRRDWCISRQRYWGTPIPV--------------------WYC----------------EDCGEVLVRRVPDVL 224
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 419 DTWFSSGLFPFSIFGWPNQSEDLSVFYPGTLLETGHDILFFWVARMVMLGLKLTGKLPFREVYLHAIVRDAHGRKMSKSL 498
Cdd:cd00818   225 DVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTRGWFYSLLLLSTALFGKAPYKNVIVHGFVLDEDGRKMSKSL 304
                         250       260
                  ....*....|....*....|....*...
gi 1039753239 499 GNVIDPLDVI--HGVSLQGLYdqLLNSN 524
Cdd:cd00818   305 GNYVDPQEVVdkYGADALRLW--VASSD 330
PTZ00427 PTZ00427
isoleucine-tRNA ligase, putative; Provisional
23-708 4.19e-29

isoleucine-tRNA ligase, putative; Provisional


Pssm-ID: 173617 [Multi-domain]  Cd Length: 1205  Bit Score: 125.46  E-value: 4.19e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   23 VEKKLWKERGLNRHQ----LGREAFLEEVWKWKAEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGV 98
Cdd:PTZ00427   155 IEYEIEKENNINKKEdilkMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNY 234
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239   99 IYRSTRLVNWSCTLNSAISDIEV--------------------------------DKKELTGRTLLPVpgYKEKVEFG-- 144
Cdd:PTZ00427   235 VYKSFKVMPYSCKCNTPISNFELnlnykdtpdpsiiisfvlcsdfpkveeecnieEDKQLLGEKYSVL--YNNKRENSnn 312
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  145 ----------------------------------VLVSFAY-KVQGSDSDEEVVVATTRIETMLGDVAVAV--------- 180
Cdd:PTZ00427   313 gnnnstnnvcyaqhseilawtttpwtlpsnlalcVNEHFTYlRIHHVKSNRVVIVGECRLEWIMKELKWNVedlkivnrf 392
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  181 ---HPKDPRYQHLKGKCV-VHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRL----EAISI--MDSKG 250
Cdd:PTZ00427   393 kgkELKGLRYKPLFTNFYeKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidpeKNIFIdpLDANG 472
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  251 ALINVPPPFLGLPRFEARKAVLAALKERGlfRGVKDNPMV--VPLCNRSKdvvEPLLR---PQWYVRcgeMAQAASAAVT 325
Cdd:PTZ00427   473 YFTNEVEEVQNLYIKEADNVIKKKLKNEN--RLLSNNTIVhsYPFCWRSD---TPLIYraiPAWFIR---VSNSTNELVK 544
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  326 RGDLRILPEAH--QRTWHSWMDNIRDWCISRQLWWGHRIPAY-------FITVHdpAVPPGEDPDG--------RYWVSg 388
Cdd:PTZ00427   545 NNETTYWIPAHikEKKFHNWIKDAKDWCISRNRYWGTPIPIWadekmetVICVE--SIKHLEELSGvknindlhRHFID- 621
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  389 rtEAEAREKAAREFGvspdkiSLQQDEDVLDTWFSSGLFPFSIFGWP--NQSEDLSVFYPGTLLETGHDILFFWVARMVM 466
Cdd:PTZ00427   622 --HIEIKNPKGKTYP------KLKRIPEVFDCWFESGSMPYAKVHYPfsTEKEDFHKIFPADFIAEGLDQTRGWFYTLLV 693
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  467 LGLKLTGKLPFREVYLHAIVRDAHGRKMSKSLGNVIDPLDVIHGVSLQGLYDQLLNSNLDPSEVEKAKEgqkadfpAGIP 546
Cdd:PTZ00427   694 ISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLINSVAVRAENLKFQE-------KGVN 766
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  547 EcgtdALRFGLCAYTSQGRDINLDVNRIlgyrhfcnKLWNATKFALRglgkgfvpsaTSKPEGHESLVDRWIRSRLTEAV 626
Cdd:PTZ00427   767 E----VVKSFILPFYHSFRFFSQEVTRY--------ECLNKKQFLFN----------TDYIYKNDNIMDQWIFSSVQSLT 824
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  627 RLSNEGFQAYDFPAITTAQYSFwLYELCDVYLECLKPVLNGV----DQVAAECarqTLYTCLDVGLRLLSPFMPFVTEEL 702
Cdd:PTZ00427   825 KSVHTEMKAYKLYNVLPKLLQF-IENLTNWYIRLNRDRMRGSlgeeNCLQSLC---TTYRTLHLFTVLMAPFTPFITEYI 900

                   ....*.
gi 1039753239  703 FQRLPR 708
Cdd:PTZ00427   901 YQQLRR 906
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ...
615-758 7.76e-29

Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 112.50  E-value: 7.76e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 615 DRWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFWLYELCDVYLECLKPVLNGVDqvAAECARQTLYTCLDVGLRLLSPF 694
Cdd:pfam08264   1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEE--PDSRAQTTLYEVLETLLRLLAPF 78
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039753239 695 MPFVTEELFQRLprrtpkapaSLCVTPYPEPSECSwkDPEAEAALELALSITRAVRSLRADYNL 758
Cdd:pfam08264  79 MPFITEELWQKE---------SIHLAPWPEDAELE--EAELEEAFELRQEIVQAIRKLRSELKI 131
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
49-706 1.70e-23

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 107.14  E-value: 1.70e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  49 KWKAEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAI------------ 116
Cdd:TIGR00396  95 KWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGTVLaneqvdsdgrsw 174
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 117 -SDIEVDKKELTgRTLLPVPGYKEKV------------------------EFGVLVSFAYKvqgsDSDEEVVVATTRIET 171
Cdd:TIGR00396 175 rGDTPVEKKELK-QWFLKITAYAEELlndleeldhwpesvkemqrnwigkSEGVEITFKIA----DHDEKITVFTTRPDT 249
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 172 MLGDVAVAVHPKDPRYQH---------------------------------LKGKCVVHPFLSRSLPIVFDDFVDMEFGT 218
Cdd:TIGR00396 250 IFGVTYLALAPEHPLVEKaaennpkvaafikkilnktvaertkatkekkgvDTGIKAIHPLTGEKIPIWVANYVLMEYGT 329
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 219 GAVKITPAHDQNDYEVGQRHRLEAISIMDS-------------KGALINvPPPFLGLPRFEARKAVLAALKERGLfrgvk 285
Cdd:TIGR00396 330 GAVMGVPAHDERDFEFAQKYGLPIKPVIDPaekdlsltaayteDGVLVN-SGEFNGLNSSEARNAIIDMLEKEGK----- 403
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 286 dnpmvvplcnrSKDVVEpllrpqwYvrcgemaqaasaavtrgdlrilpeahqrtwhswmdNIRDWCISRQLWWGHRIPAY 365
Cdd:TIGR00396 404 -----------GKRKVN-------Y-----------------------------------RLRDWGFSRQRYWGEPIPII 430
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 366 FITVHDPAVPPGED------------PDG-------RYWVSgRTEAEAREKAAREfgvspdkislqqdEDVLDTWFSSG- 425
Cdd:TIGR00396 431 HCEDGGVVPVPEEDlpvilpedvvydGDGgsplsriPEWVN-VTCPSCGKPALRE-------------TDTMDTFAGSSw 496
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 426 -LFPFSIFGWPNQSED---LSVFYPGTLLETG--HDILF-----FWVARMVMLGLkLTGKLPFREVYLHAIV-------- 486
Cdd:TIGR00396 497 yYLRYLDPKNTDGPFDkekAEYWLPVDLYIGGieHAILHllyarFFHKFLRDIGY-VNTKEPFKKLINQGMVlgfyyppn 575
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 487 ---------------RDAHGR--------KMSKSLGNVIDPLDVIHgvslqglydqllnsnldpsevekakegqkadfpa 543
Cdd:TIGR00396 576 gkvpadvlterdekgKDKAGGelvyvgyeKMSKSKGNGIDPQEIVE---------------------------------- 621
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 544 gipECGTDALRFGLCAYTSQGRDINLDVNRILGYRHFCNKLWNatkFALRGLGKgfvPSATSKPEGHESLVDRWIRSRLT 623
Cdd:TIGR00396 622 ---SYGADALRLFIMFMGPIAASLEWNESGLEGARRFLDRVWN---LVYEITGE---LDAASLTVTALEEAQKELRRDVH 692
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 624 EAVRLSNEGFQ-AYDF-PAIttAQYSFWLYEL-----CDVYLECLKPVlngvdqvaaecarqtlytcldvgLRLLSPFMP 696
Cdd:TIGR00396 693 KFLKKVTEDLEkRESFnTAI--SAMMELLNKLykakkEALMLEYLKGF-----------------------VTVLSPFAP 747
                         810
                  ....*....|
gi 1039753239 697 FVTEELFQRL 706
Cdd:TIGR00396 748 HLAEELWEKL 757
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ...
61-508 7.62e-21

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 440261 [Multi-domain]  Cd Length: 826  Bit Score: 98.20  E-value: 7.62e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  61 QLKKLGSSLDWDRACFTMDP-------KLsatvteaFVRLHEEGVIYRSTRLVNWSCTLN------------SAISDIEV 121
Cdd:COG0495   111 QLKRLGLSYDWSREIATCDPeyykwtqWI-------FLQLYEKGLAYRKEAPVNWCPVDQtvlaneqvidgrCWRCGAPV 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 122 DKKELTG----------RtLL----PVPGYKEKV----------EFGVLVSFAYKvqgsDSDEEVVVATTRIETMLGD-- 175
Cdd:COG0495   184 EKKELPQwflkitdyadE-LLddldKLDGWPEKVktmqrnwigrSEGAEVDFPVE----GSDEKITVFTTRPDTLFGAtf 258
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 176 VAVAV-HP---------KDPRYQHLKGKC-----------------------VVHPFLSRSLPIVFDDFVDMEFGTGAVK 222
Cdd:COG0495   259 MVLAPeHPlvkelatpeQNAAVAAFIEEAkkkseiertsetkektgvftglyAINPLTGEKIPIWIADYVLMDYGTGAVM 338
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 223 ITPAHDQNDYEVGQRHRL-----------EAISIMDS----KGALINvPPPFLGLPRFEARKAVLAALKERGLfrgvkdn 287
Cdd:COG0495   339 AVPAHDQRDFEFAKKYGLpikqviapedgDDPDILEEaytgDGVLIN-SGEFDGLDSEEAKEAIIEWLEEKGL------- 410
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 288 pmvvplcnrskdvvepllrpqwyvrcGEmaqaasAAVT-RgdlrilpeahqrtwhswmdnIRDWCISRQLWWGHRIPAyf 366
Cdd:COG0495   411 --------------------------GK------RKVNyR--------------------LRDWLISRQRYWGEPIPI-- 436
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 367 itVHDP-----AVP----------------PGEDPDGRY--WVS------GRteaeareKAAREFgvspdkislqqdeDV 417
Cdd:COG0495   437 --IHCEdcgvvPVPedqlpvelpedvdfdpTGGSPLARApeWVNvtcpkcGG-------PARRET-------------DT 494
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 418 LDTWF-SSglfpfsifgW-------PNQSE--------------DLsvfYPGtlletG--HDIL------FFWvarMVM- 466
Cdd:COG0495   495 MDTFVdSS---------WyylrytdPHNDEapfdpeaanywlpvDQ---YIG-----GieHAILhllyarFFT---KVLr 554
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1039753239 467 -LGLkLTGKLPFR---------EVYLHAIVRDAHGrKMSKSLGNVIDPLDVI 508
Cdd:COG0495   555 dLGL-VSFDEPFKrlltqgmvlEVGKDGVVIGGIE-KMSKSKGNVVDPDEII 604
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
62-733 2.14e-19

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 93.78  E-value: 2.14e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  62 LKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDieVDKKELTGrtllpvpgyKEKV 141
Cdd:PRK12300   89 MKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGD--HDLLDGEE---------PEIV 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 142 EFgVLVSFAykvqgsDSDEEV-VVATTRIETMLGDVAVAVHPKDP---------------------RYQH---------- 189
Cdd:PRK12300  158 EY-TLIKFE------ESEDLIlPAATLRPETIFGVTNLWVNPDATyvkaevdgekwivskeaaeklSFQDrdveiieeik 230
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 190 ---LKGKCVVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDY----EVGQRHRL----EAISIMD----------- 247
Cdd:PRK12300  231 gseLIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELldviEPIPLIEvegygefpake 310
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 248 ---------------------------SKGALINVPPPFLGLPRFEARKAVLAALKERGLfrGVK----DNPMVVPLCNr 296
Cdd:PRK12300  311 vveklgiksqedpeleeatkevyraefHKGVLKENTGEYAGKPVREAREKITKDLIEKGI--ADImyefSNRPVYCRCG- 387
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 297 SKDVVEpLLRPQWYVRCGEMAQAASA--AVTRgdLRILPEAHQRTWHSWMDNIRDWCISRQLWWGHRIP----------- 363
Cdd:PRK12300  388 TECVVK-VVKDQWFIDYSDPEWKELAhkALDN--MEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLPwdeewiiesls 464
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 364 ------AYFITVHdpavppgedpdgrywvsgrteaearekAAREFGVSPDKIslqqDEDVLDTWFSSGLFPFSIfgwpnq 437
Cdd:PRK12300  465 dstiymAYYTIAH---------------------------KIREYGIKPEQL----TPEFFDYVFLGKGDPEEV------ 507
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 438 SEDLSVfyPGTLLETGHDILFFWVArmvmLGLKLTGK------LPFReVYLH-AIVRDAH--------------GRKMSK 496
Cdd:PRK12300  508 SKKTGI--PKEILEEMREEFLYWYP----VDWRHSGKdlipnhLTFF-IFNHvAIFPEEKwprgivvngfvlleGKKMSK 580
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 497 SLGNVIdPLdvihgvslqglydqllnsnldpsevEKAKEgqkadfpagipECGTDALRFGLCAYTSQGRDINLDVNRILG 576
Cdd:PRK12300  581 SKGNVI-PL-------------------------RKAIE-----------EYGADVVRLYLTSSAELLQDADWREKEVES 623
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 577 YRHFCNKLWNatkFALRGLGKGfvpsatskPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDF-PAITTAQYSfwLYELCD 655
Cdd:PRK12300  624 VRRQLERFYE---LAKELIEIG--------GEEELRFIDKWLLSRLNRIIKETTEAMESFQTrDAVQEAFYE--LLNDLR 690
                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039753239 656 VYLEcLKPVLNgvdqvaaecaRQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTpkaPASLcvTPYPEPSEcSWKDP 733
Cdd:PRK12300  691 WYLR-RVGEAN----------NKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEG---FVSL--EKWPEPDE-SKIDE 751
Anticodon_Ia_Ile_ABEc cd07961
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ...
578-727 1.51e-17

Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153415 [Multi-domain]  Cd Length: 183  Bit Score: 81.44  E-value: 1.51e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 578 RHFCNKLWNATKFAL--RGLgKGFVPSATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFWLyELCD 655
Cdd:cd07961    11 RKVLLPLWNAYRFFVtyANL-DGFDPGKDDDAVASLNVLDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFID-ELTN 88
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039753239 656 VYL----ECLKPVLNGVDQVAAecaRQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTPKAPASLCVTPYPEPSE 727
Cdd:cd07961    89 WYIrrnrKRFWGEEGDDDKLAA---YATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPESVHLLDWPEVDE 161
PLN02563 PLN02563
aminoacyl-tRNA ligase
18-379 6.93e-16

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 82.56  E-value: 6.93e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  18 ATQVVveKKLWKERGLN-RHQLGREAFLEEVWKWKAEKG-----------DRIYHQLKKLGSSLDWDRACFTMDPKLSAT 85
Cdd:PLN02563  136 ATDIL--ARYKRMQGYNvLHPMGWDAFGLPAEQYAIETGthpkittlkniARFRSQLKSLGFSYDWDREISTTEPEYYKW 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  86 VTEAFVRLHEEGVIYRSTRLVNWSCTLNSAISDIEVDK--KELTGRTLLPVP--------------------------GY 137
Cdd:PLN02563  214 TQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVDglSERGGHPVIRKPmrqwmlkitayadrlledlddldwpeSI 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 138 KE------------KVEFGVLvsfayKVQGSDSDEEVVVATTRIETMLGDVAVAVHPKDP-------------------- 185
Cdd:PLN02563  294 KEmqrnwigrsegaELDFSVL-----DGEGKERDEKITVYTTRPDTLFGATYLVVAPEHPllsslttaeqkeaveeyvda 368
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 186 --------RYQHLKGKCVV-------HPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRLEAISIMDS-- 248
Cdd:PLN02563  369 asrksdleRTELQKEKTGVftgsyaiNPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKPad 448
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 249 ------------KGALINVPPPFL---GLPRFEARKAVLAALKERGlfrgvkdnpmvvplcNRSKDVVEPLlrpqwyvrc 313
Cdd:PLN02563  449 gneddaekaytgEGVIVNSSSSGLdinGLSSKEAAKKVIEWLEETG---------------NGKKKVNYKL--------- 504
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039753239 314 gemaqaasaavtrgdlrilpeahqrtwhswmdniRDWCISRQLWWGHRIPAYFITVHDPAVPPGED 379
Cdd:PLN02563  505 ----------------------------------RDWLFARQRYWGEPIPVVFLEDSGEPVPVPES 536
Anticodon_Ia_Ile_BEm cd07960
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ...
577-733 6.64e-13

Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.


Pssm-ID: 153414 [Multi-domain]  Cd Length: 180  Bit Score: 67.94  E-value: 6.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 577 YRhfcnKLWNATKFALRGLGkGFVPSATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFWLYELCDV 656
Cdd:cd07960    13 YR----KIRNTFRFLLGNLN-DFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAF 87
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039753239 657 YLECLKPVL--NGVDQVAAECARQTLYTCLDVGLRLLSPFMPFVTEELFQRLPRRTPKAPASLcvTPYPEPSEcSWKDP 733
Cdd:cd07960    88 YLDIIKDRLycDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLPGEKKEESVFL--EDWPELPE-EWKDE 163
tRNA-synt_1_2 pfam13603
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ...
144-271 2.33e-12

Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.


Pssm-ID: 433342 [Multi-domain]  Cd Length: 185  Bit Score: 66.42  E-value: 2.33e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 144 GVLVSFAYKvqgsDSDEEVVVATTRIETMLGD--VAVAV-HP-------KDPRYQHLKGKC------------------- 194
Cdd:pfam13603   9 GAEITFPVE----GTDEKIEVFTTRPDTLMGVtfVALAPeHPlveklaeKNPEVAAFIEECkntseiertsetkekegvf 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 195 ----VVHPFLSRSLPIVFDDFVDMEFGTGAVKITPAHDQNDYEVGQRHRL------------EAISIMDS----KGALIN 254
Cdd:pfam13603  85 tglyAIHPITGEKIPIWIANFVLMEYGTGAVMAVPAHDQRDFEFAKKYNLpikpviqpedgdLDLDIMTEayteEGILVN 164
                         170
                  ....*....|....*..
gi 1039753239 255 vPPPFLGLPRFEARKAV 271
Cdd:pfam13603 165 -SGEFDGLDSEEAKEAI 180
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ...
342-706 8.43e-11

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases


Pssm-ID: 439913 [Multi-domain]  Cd Length: 544  Bit Score: 65.52  E-value: 8.43e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 342 SWMDN-IRDWCISRQLWWGhrIPayfitvhdpaVPpgEDPDGRYWVsgrteaearekaarefgvspdkislqqdedvldt 420
Cdd:COG0143   217 SWLKEgLQDLSISRDFDWG--IP----------VP--GDPGKVFYV---------------------------------- 248
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 421 WF-------SSglfpfsIFGWP---NQSEDLSVFYPGTLLETGH----DILFF----WVArMVM-LGLKLTGKLPfrevy 481
Cdd:COG0143   249 WFdaligyiSA------TKGYAddrGLPEDFEKYWPAPDTELVHfigkDIIRFhaiiWPA-MLMaAGLPLPKKVF----- 316
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 482 lhaivrdAH------GRKMSKSLGNVIDPLDVIhgvslqglydqllnsnldpsevekakegqkADFPAgipecgtDALRF 555
Cdd:COG0143   317 -------AHgfltveGEKMSKSRGNVIDPDDLL------------------------------DRYGP-------DALRY 352
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 556 GLCAYTSQGRDINLD-------------------VNRILGyrhFCNKLWNatkfalrglgkGFVPSAtskpeGHESLVDR 616
Cdd:COG0143   353 YLLREVPFGQDGDFSwedfvarvnsdlandlgnlASRTLS---MIHKYFD-----------GKVPEP-----GELTEADE 413
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 617 WIRSRLTEAVRLSNEGFQAYDFPAITTAqysfwLYELCDV---YLECLKP-VLngVDQVAAECARQTLYTCLDVgLR--- 689
Cdd:COG0143   414 ELLAEAEAALEEVAEAMEAFEFRKALEE-----IMALARAankYIDETAPwKL--AKDEDPERLATVLYTLLEA-LRila 485
                         410
                  ....*....|....*...
gi 1039753239 690 -LLSPFMPFVTEELFQRL 706
Cdd:COG0143   486 iLLKPFLPETAEKILEQL 503
Anticodon_Ia_like cd07375
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ...
572-695 2.02e-08

Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.


Pssm-ID: 153408 [Multi-domain]  Cd Length: 117  Bit Score: 53.28  E-value: 2.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 572 NRILGYRHFCNKLWNATKFALRGLGKGFVPSATSKPEGheslVDRWIRSRLTEAVRLSNEGFQAYDFPAITTAQYSFWLY 651
Cdd:cd07375     2 ERLKQARAFLNRLYRLLSFFRKALGGTQPKWDNELLEE----ADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNE 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1039753239 652 ElcDVYLECLKPVLNgvDQVAAECARQTLYTCLDVGLRLLSPFM 695
Cdd:cd07375    78 L--NWYLDELKPALQ--TEELREAVLAVLRAALVVLTKLLAPFT 117
Anticodon_Ia_Leu_AEc cd07959
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ...
602-706 9.65e-08

Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153413 [Multi-domain]  Cd Length: 117  Bit Score: 51.05  E-value: 9.65e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 602 SATSKPEGHESLVDRWIRSRLTEAVRLSNEGFQAYDF-PAITTAQYSFwlYELCDVYLEclkpvlngvdQVAAECARQTL 680
Cdd:cd07959    24 IETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFrEALKEGLYEL--QNDLDWYRE----------RGGAGMNKDLL 91
                          90       100
                  ....*....|....*....|....*.
gi 1039753239 681 YTCLDVGLRLLSPFMPFVTEELFQRL 706
Cdd:cd07959    92 RRFIEVWTRLLAPFAPHLAEEIWHEL 117
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
409-706 1.01e-06

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 52.19  E-value: 1.01e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 409 ISLQQDED-VLDTWFSsGLFPF-SIFGWPNQSEDLSV----FYPGTLLETGHDILFF----WVARMVMLGLKLTGKlpfr 478
Cdd:PRK11893  212 IPVPGDPKhVIYVWFD-ALTNYlTALGYPDDEELLAElfnkYWPADVHLIGKDILRFhavyWPAFLMAAGLPLPKR---- 286
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 479 eVYLHA-IVRDahGRKMSKSLGNVIDPLDVIHgvslqglydqllnsnldpsevekakegqkadfpagipECGTDALRFGL 557
Cdd:PRK11893  287 -VFAHGfLTLD--GEKMSKSLGNVIDPFDLVD-------------------------------------EYGVDAVRYFL 326
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 558 CAYTSQGRDINLDVNRILGYR--HFCNKLWN---ATKFALRGLGKGFVPSATSKPEGHESLVDRWIRSRltEAVRlsneg 632
Cdd:PRK11893  327 LREIPFGQDGDFSREAFINRInaDLANDLGNlaqRTLSMIAKNFDGKVPEPGALTEADEALLEAAAALL--ERVR----- 399
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 633 fQAYDFPAITTAQYSFW-LYELCDVYLECLKP-VLNGVDQvaaECARQTLYTCLDvGLR----LLSPFMPFVTEELFQRL 706
Cdd:PRK11893  400 -AAMDNLAFDKALEAILaLVRAANKYIDEQAPwSLAKTDP---ERLATVLYTLLE-VLRgiavLLQPVMPELAAKILDQL 474
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
433-508 1.26e-06

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 52.11  E-value: 1.26e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 433 GWPNQSEDLS-VFYPGTLLETGHDIL-F---FWVARMVMLGLKLtgklpFREVYLHA-IVRDahGRKMSKSLGNVIDPLD 506
Cdd:PRK12267  240 GYGSDDDELFkKFWPADVHLVGKDILrFhaiYWPIMLMALGLPL-----PKKVFAHGwWLMK--DGKMSKSKGNVVDPEE 312

                  ..
gi 1039753239 507 VI 508
Cdd:PRK12267  313 LV 314
Val_tRNA-synt_C pfam10458
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ...
827-889 7.13e-05

Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.


Pssm-ID: 431296 [Multi-domain]  Cd Length: 66  Bit Score: 41.48  E-value: 7.13e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039753239 827 DPARELGKLQAKRSEAQRQAQRLQERRAASSYSAKVPLEVQEADEAKLQQTEAELRKVDEAIA 889
Cdd:pfam10458   1 DVEKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLS 63
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
49-108 2.15e-04

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 44.16  E-value: 2.15e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239  49 KWKAEKGDRIYHQLKKLGSSLDWDRACFTMDPKLSATVTEAFVRLHEEGVIYRSTRLVNW 108
Cdd:cd00812    66 DWTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNW 125
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
305-508 4.02e-04

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 43.39  E-value: 4.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 305 LRPQWYVRCGEMAQAASAAVTRGDLRILPEAHQRTWHSWMDnirdwcISRQLWWGHRIPayfitvhdpavppgedpdgry 384
Cdd:cd00812   128 LLDQWFLKYSETEWKEKLLKDLEKLDGWPEEVRAMQENWIG------CSRQRYWGTPIP--------------------- 180
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 385 WvsgrteaearekaarefgvspdkislqqdEDVLDTWFSSGLFP--FSIFGWPNQ---------SEDLSVFYPGTLLETG 453
Cdd:cd00812   181 W-----------------------------TDTMESLSDSTWYYarYTDAHNLEQpyegdlefdREEFEYWYPVDIYIGG 231
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039753239 454 HD-----ILF--FWVArmVMLGLKLTGKLPFREVYLHAIVRdAHGRKMSKSLGNVIDPLDVI 508
Cdd:cd00812   232 KEhapnhLLYsrFNHK--ALFDEGLVTDEPPKGLIVQGMVL-LEGEKMSKSKGNVVTPDEAI 290
PLN02224 PLN02224
methionine-tRNA ligase
385-509 8.41e-04

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 43.16  E-value: 8.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 385 WVSGRTEAEAREKAAREFGVS-PDkislqQDEDVLDTWFSSGLFPFSIFGWPNQSEDL----SVFYPGTLLETGHDILFF 459
Cdd:PLN02224  260 WIKSGLRDFSISRALVDWGIPvPD-----DDKQTIYVWFDALLGYISALTEDNKQQNLetavSFGWPASLHLIGKDILRF 334
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1039753239 460 ----WVARMVMLGLKLTgKLPFREVYLhaiVRDahGRKMSKSLGNVIDPLDVIH 509
Cdd:PLN02224  335 havyWPAMLMSAGLELP-KMVFGHGFL---TKD--GMKMGKSLGNTLEPFELVQ 382
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
342-508 3.03e-03

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 40.59  E-value: 3.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 342 SWMDN-IRDWCISRQLW-WGhrIPayfitvhdpaVPpgEDPDGRYWVsgrteaearekaarefgvspdkislqqdedvld 419
Cdd:cd00814   173 SWLKEgLKDLSITRDLFdWG--IP----------VP--LDPGKVIYV--------------------------------- 205
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039753239 420 tWF-------SSGLFPFSIFG-----WPNQSEDLSVFypgtlletGHDILFF----WVArMVM-LGLKLTGKLPfrevyl 482
Cdd:cd00814   206 -WFdaligyiSATGYYNEEWGnswwwKDGWPELVHFI--------GKDIIRFhaiyWPA-MLLgAGLPLPTRIV------ 269
                         170       180       190
                  ....*....|....*....|....*....|..
gi 1039753239 483 haivrdAH------GRKMSKSLGNVIDPLDVI 508
Cdd:cd00814   270 ------AHgyltveGKKMSKSRGNVVDPDDLL 295
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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