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Conserved domains on  [gi|1039755873|ref|XP_017173377|]
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protein FAM170A isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Spt46 super family cl39262
Spermatogenesis-associated protein 46; This family is found in chordata. Functional ...
 34-151 2.49e-11

Spermatogenesis-associated protein 46; This family is found in chordata. Functional characterization studies showed that the deletion of Spata46 in mice resulted in subfertility with abnormal sperm head shape and a failure of sperm-egg fusion. Spata46 has also been shown to localize to the nuclear membrane by a transmembrane region in the N-terminal.


The actual alignment was detected with superfamily member pfam17734:

Pssm-ID: 375300  Cd Length: 228  Bit Score: 61.05  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755873  34 LEKQPRMEEATLPE-----GVWVGTPPSDVSTRNLLSDSEPIGEEKEHEEKPESDSPPGSPAVEERPRAKTPDWLVTMEN 108
Cdd:pfam17734 105 TDKESHLEAYSFPEvqrdeGRGDSCLPEDTAESVCSSSSSPENTCPREATRKARHGLDSADSITSQDILMASRWHPAQQN 184

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1039755873 109 GFRCMACCRVFATMESLQEHVQYGIREGFSCHVFHLTMAQLIG 151
Cdd:pfam17734 185 GYKCAACCRMYPTLHSLKSHIKGGFKEGFSCRVYYRKLKTLWG 227
 
Name Accession Description Interval E-value
Spt46 pfam17734
Spermatogenesis-associated protein 46; This family is found in chordata. Functional ...
 34-151 2.49e-11

Spermatogenesis-associated protein 46; This family is found in chordata. Functional characterization studies showed that the deletion of Spata46 in mice resulted in subfertility with abnormal sperm head shape and a failure of sperm-egg fusion. Spata46 has also been shown to localize to the nuclear membrane by a transmembrane region in the N-terminal.


Pssm-ID: 375300  Cd Length: 228  Bit Score: 61.05  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755873  34 LEKQPRMEEATLPE-----GVWVGTPPSDVSTRNLLSDSEPIGEEKEHEEKPESDSPPGSPAVEERPRAKTPDWLVTMEN 108
Cdd:pfam17734 105 TDKESHLEAYSFPEvqrdeGRGDSCLPEDTAESVCSSSSSPENTCPREATRKARHGLDSADSITSQDILMASRWHPAQQN 184

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1039755873 109 GFRCMACCRVFATMESLQEHVQYGIREGFSCHVFHLTMAQLIG 151
Cdd:pfam17734 185 GYKCAACCRMYPTLHSLKSHIKGGFKEGFSCRVYYRKLKTLWG 227
 
Name Accession Description Interval E-value
Spt46 pfam17734
Spermatogenesis-associated protein 46; This family is found in chordata. Functional ...
 34-151 2.49e-11

Spermatogenesis-associated protein 46; This family is found in chordata. Functional characterization studies showed that the deletion of Spata46 in mice resulted in subfertility with abnormal sperm head shape and a failure of sperm-egg fusion. Spata46 has also been shown to localize to the nuclear membrane by a transmembrane region in the N-terminal.


Pssm-ID: 375300  Cd Length: 228  Bit Score: 61.05  E-value: 2.49e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039755873  34 LEKQPRMEEATLPE-----GVWVGTPPSDVSTRNLLSDSEPIGEEKEHEEKPESDSPPGSPAVEERPRAKTPDWLVTMEN 108
Cdd:pfam17734 105 TDKESHLEAYSFPEvqrdeGRGDSCLPEDTAESVCSSSSSPENTCPREATRKARHGLDSADSITSQDILMASRWHPAQQN 184

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1039755873 109 GFRCMACCRVFATMESLQEHVQYGIREGFSCHVFHLTMAQLIG 151
Cdd:pfam17734 185 GYKCAACCRMYPTLHSLKSHIKGGFKEGFSCRVYYRKLKTLWG 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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