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Conserved domains on  [gi|1039761671|ref|XP_017174694|]
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protein TANC1 isoform X4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1069-1285 3.05e-52

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 186.31  E-value: 3.05e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1069 GETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1148
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1149 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1228
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761671 1229 HVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEE 1285
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKL 270
PHA03095 super family cl33707
ankyrin-like protein; Provisional
 896-1208 9.54e-22

ankyrin-like protein; Provisional


The actual alignment was detected with superfamily member PHA03095:

Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.87  E-value: 9.54e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  896 RNLYTPNVKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLGHE---EVVTLLLEFGACLDGMSENGMNAL-CYAAAAG 969
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  970 HMKLVCLLIKKGARVDHLDKKGQCALvHSALRG---HSDILQYLLNcewsagppqpgtlrksqalqqaltaaasMGhssv 1046
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLR----------------------------KG---- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1047 vqsllgmaeeheIEVNGTDtLWGETALTA--AAGRGKVEICELLLERGAAVSRANRRGVPPL-----FCAARQGhwqVVR 1119
Cdd:PHA03095   143 ------------ADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAVDDRFRSLLhhhlqSFKPRAR---IVR 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1120 LLLDRGCDVNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQT 1197
Cdd:PHA03095   207 ELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286

                          330
                   ....*....|.
gi 1039761671 1198 DKNGRTPLDLA 1208
Cdd:PHA03095   287 SSDGNTPLSLM 297
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1286-1403 4.02e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 4.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1286 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1365
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1039761671 1366 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
NACHT super family cl26020
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
511-1132 2.91e-09

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG5635:

Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 62.13  E-value: 2.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  511 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTSLRNEQKIpeeeyIILIDGLNE--A 587
Cdd:COG5635    196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEvpD 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  588 EFHKPDYGDTLSSFITKiipkFPTwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSN 667
Cdd:COG5635    271 EADRDEVLNQLRRFLER----YPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEA 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  668 ISLNGKadaaliskvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFDRALP 746
Cdd:COG5635    345 LEENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLT 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  747 ILN-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMEALSCFLIKRRDKTRMFCHPSFRE 809
Cdd:COG5635    401 IYRelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQE 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  810 WLV-----WRADGESTAFL----CEPRNgHALLAFMFSRQESKLNRQQTMELGHHILKAHIFKGLSKKTGVSS--SHLQA 878
Cdd:COG5635    480 YLAaralvEELDEELLELLaehlEDPRW-REVLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALLLALLlaLALLA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  879 LWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENG 958
Cdd:COG5635    559 LLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLL 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  959 MNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLRKSQALQQALTAA 1038
Cdd:COG5635    639 LALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAALDL 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1039 ASMGHSSVVQSLLGMAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVV 1118
Cdd:COG5635    719 LLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLLL 798

                          650
                   ....*....|....
gi 1039761671 1119 RLLLDRGCDVNLSD 1132
Cdd:COG5635    799 ILLLVLLGSLLLLR 812
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1069-1285 3.05e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 186.31  E-value: 3.05e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1069 GETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1148
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1149 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1228
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761671 1229 HVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEE 1285
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKL 270
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1082-1306 5.90e-24

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 107.06  E-value: 5.90e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1082 VEICELLLERGAAVSRANRRGVPPLFCAA--RQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVA--SCEGHLSTVEFLLSK 1157
Cdd:PHA03100    86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDK 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1158 GAALSSLDKeglsalswaclkghravVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRP 1237
Cdd:PHA03100   166 GVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761671 1238 LDRAIGCRNTAVVVTLLRKGaklgnaawamATSKPDILIILLQKLVEEGNVmyKKGKMKEAAQRYQYAL 1306
Cdd:PHA03100   229 LHIAILNNNKEIFKLLLNNG----------PSIKTIIETLLYFKDKDLNTI--TKIKMLKKSIMYMFLL 285
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1106-1198 3.07e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.49  E-value: 3.07e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1106 LFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAlsSLDKEGLSALSWACLKGHRAVVQ 1185
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039761671 1186 YLVEEGAEIDQTD 1198
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 896-1208 9.54e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.87  E-value: 9.54e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  896 RNLYTPNVKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLGHE---EVVTLLLEFGACLDGMSENGMNAL-CYAAAAG 969
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  970 HMKLVCLLIKKGARVDHLDKKGQCALvHSALRG---HSDILQYLLNcewsagppqpgtlrksqalqqaltaaasMGhssv 1046
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLR----------------------------KG---- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1047 vqsllgmaeeheIEVNGTDtLWGETALTA--AAGRGKVEICELLLERGAAVSRANRRGVPPL-----FCAARQGhwqVVR 1119
Cdd:PHA03095   143 ------------ADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAVDDRFRSLLhhhlqSFKPRAR---IVR 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1120 LLLDRGCDVNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQT 1197
Cdd:PHA03095   207 ELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286

                          330
                   ....*....|.
gi 1039761671 1198 DKNGRTPLDLA 1208
Cdd:PHA03095   287 SSDGNTPLSLM 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
962-1093 1.98e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 1.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  962 LCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNcewsagppqpgtlrksqalqqaltaaasm 1041
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE----------------------------- 51

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1042 ghssvvqsllgmaeeheiEVNGTDTLWGETALTAAAGRGKVEICELLLERGA 1093
Cdd:pfam12796   52 ------------------HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGA 85
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1286-1403 4.02e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 4.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1286 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1365
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1039761671 1366 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
511-1132 2.91e-09

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 62.13  E-value: 2.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  511 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTSLRNEQKIpeeeyIILIDGLNE--A 587
Cdd:COG5635    196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEvpD 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  588 EFHKPDYGDTLSSFITKiipkFPTwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSN 667
Cdd:COG5635    271 EADRDEVLNQLRRFLER----YPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEA 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  668 ISLNGKadaaliskvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFDRALP 746
Cdd:COG5635    345 LEENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLT 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  747 ILN-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMEALSCFLIKRRDKTRMFCHPSFRE 809
Cdd:COG5635    401 IYRelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQE 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  810 WLV-----WRADGESTAFL----CEPRNgHALLAFMFSRQESKLNRQQTMELGHHILKAHIFKGLSKKTGVSS--SHLQA 878
Cdd:COG5635    480 YLAaralvEELDEELLELLaehlEDPRW-REVLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALLLALLlaLALLA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  879 LWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENG 958
Cdd:COG5635    559 LLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLL 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  959 MNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLRKSQALQQALTAA 1038
Cdd:COG5635    639 LALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAALDL 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1039 ASMGHSSVVQSLLGMAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVV 1118
Cdd:COG5635    719 LLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLLL 798

                          650
                   ....*....|....
gi 1039761671 1119 RLLLDRGCDVNLSD 1132
Cdd:COG5635    799 ILLLVLLGSLLLLR 812
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1069-1188 5.09e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 5.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1069 GETALTAAAGRGKVEICELLLERGAAVS---------RANRR-----GVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQ 1134
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039761671 1135 GRTPLMV--------ASCEghlsTVEFLLS--KGAALSSLD----KEGLSALSWACLKGHRAVVQYLV 1188
Cdd:cd22192    169 GNTVLHIlvlqpnktFACQ----MYDLILSydKEDDLQPLDlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1069-1209 4.96e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.07  E-value: 4.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1069 GETALTAAAGRGKVEICELLLERGAAVS-RAN-------------RRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQ 1134
Cdd:TIGR00870  128 GITALHLAAHRQNYEIVKLLLERGASVPaRACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1135 GRTPLmvascegHLSTVEfllskgaALSSLDKEGLSalswaclkghRAVVQYLVEEGAEIDQTDK-------NGRTPLDL 1207
Cdd:TIGR00870  208 GNTLL-------HLLVME-------NEFKAEYEELS----------CQMYNFALSLLDKLRDSKElevilnhQGLTPLKL 263


                   ..
gi 1039761671 1208 AA 1209
Cdd:TIGR00870  264 AA 265
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 1327-1393 9.10e-04

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 44.14  E-value: 9.10e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761671 1327 SLYLNLSRCRRKTNDFGLAEEFASKALELKPkSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNN 1393
Cdd:PRK09782   577 ALYWWLHAQRYIPGQPELALNDLTRSLNIAP-SANAYVARATIYRQRHNVPAAVSDLRAALELEPNN 642
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1200-1228 1.14e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.14e-03
                            10        20
                    ....*....|....*....|....*....
gi 1039761671  1200 NGRTPLDLAAFYGDAETVLYLVEKGAVIE 1228
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1290-1402 3.03e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 3.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1290 YKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARA 1369
Cdd:TIGR02917  510 IQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY 576

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1039761671 1370 KRNSRQFLAALADLQEAVKLCPNNQEIKRLLAR 1402
Cdd:TIGR02917  577 YLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
TPR_14 pfam13428
Tetratricopeptide repeat;
1361-1403 3.72e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 37.02  E-value: 3.72e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039761671 1361 EAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 957-985 4.43e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.43e-03
                            10        20
                    ....*....|....*....|....*....
gi 1039761671   957 NGMNALCYAAAAGHMKLVCLLIKKGARVD 985
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1069-1285 3.05e-52

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 186.31  E-value: 3.05e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1069 GETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1148
Cdd:COG0666     54 GALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNL 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1149 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIE 1228
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761671 1229 HVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEE 1285
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKL 270
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1053-1264 7.94e-51

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 182.08  E-value: 7.94e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1053 MAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSD 1132
Cdd:COG0666     71 LLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQD 150

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1133 KQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYG 1212
Cdd:COG0666    151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1213 DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAA 1264
Cdd:COG0666    231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAAL 282
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
923-1238 3.99e-46

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 168.59  E-value: 3.99e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  923 LNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRG 1002
Cdd:COG0666     19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1003 HSDILQYLLncewsagppqpgtlrksqalqqaltaaasmghssvvqsllgmaeEHEIEVNGTDTlWGETALTAAAGRGKV 1082
Cdd:COG0666     99 DLEIVKLLL--------------------------------------------EAGADVNARDK-DGETPLHLAAYNGNL 133

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1083 EICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALS 1162
Cdd:COG0666    134 EIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761671 1163 SLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1238
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
890-1205 1.40e-42

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 158.19  E-value: 1.40e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  890 AALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAG 969
Cdd:COG0666     19 LLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNG 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  970 HMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLncewsagppqpgtlrksqalqqaltaaasmghssvvqs 1049
Cdd:COG0666     99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLL-------------------------------------- 140

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1050 llgmaeEHEIEVNGTDTlWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVN 1129
Cdd:COG0666    141 ------EAGADVNAQDN-DGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVN 213

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761671 1130 LSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPL 1205
Cdd:COG0666    214 AKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1050-1317 3.10e-41

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 154.34  E-value: 3.10e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1050 LLGMAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVN 1129
Cdd:COG0666      2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1130 LSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAA 1209
Cdd:COG0666     82 AKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAA 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1210 FYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGA------KLGNAA--WAMATSKPDILIILLQK 1281
Cdd:COG0666    162 ANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAdvnakdNDGKTAldLAAENGNLEIVKLLLEA 241

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 1039761671 1282 LVEEGNVMYKKGKMKEAAQRYQYALRKFPREGLGED 1317
Cdd:COG0666    242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLL 277
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1082-1281 4.88e-28

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 116.21  E-value: 4.88e-28
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1082 VEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAL 1161
Cdd:COG0666      1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADI 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1162 SSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRA 1241
Cdd:COG0666     81 NAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLA 160

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|....*...
gi 1039761671 1242 IGCRNTAVVVTLLRKGA------KLGNAA--WAMATSKPDILIILLQK 1281
Cdd:COG0666    161 AANGNLEIVKLLLEAGAdvnardNDGETPlhLAAENGHLEIVKLLLEA 208
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1082-1306 5.90e-24

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 107.06  E-value: 5.90e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1082 VEICELLLERGAAVSRANRRGVPPLFCAA--RQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVA--SCEGHLSTVEFLLSK 1157
Cdd:PHA03100    86 KEIVKLLLEYGANVNAPDNNGITPLLYAIskKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYleSNKIDLKILKLLIDK 165

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1158 GAALSSLDKeglsalswaclkghravVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRP 1237
Cdd:PHA03100   166 GVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761671 1238 LDRAIGCRNTAVVVTLLRKGaklgnaawamATSKPDILIILLQKLVEEGNVmyKKGKMKEAAQRYQYAL 1306
Cdd:PHA03100   229 LHIAILNNNKEIFKLLLNNG----------PSIKTIIETLLYFKDKDLNTI--TKIKMLKKSIMYMFLL 285
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1106-1198 3.07e-22

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 92.49  E-value: 3.07e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1106 LFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAlsSLDKEGLSALSWACLKGHRAVVQ 1185
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039761671 1186 YLVEEGAEIDQTD 1198
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 896-1208 9.54e-22

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 100.87  E-value: 9.54e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  896 RNLYTPNVKVS--RLLILGGANVNYRTEvLNNAPiLCVQSHLGHE---EVVTLLLEFGACLDGMSENGMNAL-CYAAAAG 969
Cdd:PHA03095    18 YLLNASNVTVEevRRLLAAGADVNFRGE-YGKTP-LHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLhLYLYNAT 95

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  970 HMKLVCLLIKKGARVDHLDKKGQCALvHSALRG---HSDILQYLLNcewsagppqpgtlrksqalqqaltaaasMGhssv 1046
Cdd:PHA03095    96 TLDVIKLLIKAGADVNAKDKVGRTPL-HVYLSGfniNPKVIRLLLR----------------------------KG---- 142

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1047 vqsllgmaeeheIEVNGTDtLWGETALTA--AAGRGKVEICELLLERGAAVSRANRRGVPPL-----FCAARQGhwqVVR 1119
Cdd:PHA03095   143 ------------ADVNALD-LYGMTPLAVllKSRNANVELLRLLIDAGADVYAVDDRFRSLLhhhlqSFKPRAR---IVR 206

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1120 LLLDRGCDVNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQT 1197
Cdd:PHA03095   207 ELIRAGCDPAATDMLGNTPLhsMATGSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAV 286

                          330
                   ....*....|.
gi 1039761671 1198 DKNGRTPLDLA 1208
Cdd:PHA03095   287 SSDGNTPLSLM 297
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1139-1231 3.44e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 86.71  E-value: 3.44e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1139 LMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEgAEIDQTDkNGRTPLDLAAFYGDAETVL 1218
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78

                           90
                   ....*....|...
gi 1039761671 1219 YLVEKGAVIEHVD 1231
Cdd:pfam12796   79 LLLEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1073-1159 4.45e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 83.63  E-value: 4.45e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1073 LTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRgCDVNLSDkQGRTPLMVASCEGHLSTVE 1152
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVK 78


                   ....*..
gi 1039761671 1153 FLLSKGA 1159
Cdd:pfam12796   79 LLLEKGA 85
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 948-1264 2.53e-17

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 86.94  E-value: 2.53e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  948 GACLDGMSENGMNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLL-NCEWSAGPPQPGTlr 1026
Cdd:PHA02874    25 GNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIdNGVDTSILPIPCI-- 102

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1027 ksqalqqaltaaasmgHSSVVQSLLgmaeEHEIEVNGTDTLwGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPL 1106
Cdd:PHA02874   103 ----------------EKDMIKTIL----DCGIDVNIKDAE-LKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPI 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1107 FCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKgHRAVVQY 1186
Cdd:PHA02874   162 HIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIH-NRSAIEL 240

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761671 1187 LVEEgAEIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAA 1264
Cdd:PHA02874   241 LINN-ASINDQDIDGSTPLHHAINPPcDIDIIDILLYHKADISIKDNKGENPIDTAFKYINKDPVIKDIIANAVLIKEA 318
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1082-1258 2.17e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 84.31  E-value: 2.17e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1082 VEICELLLERGAAVSRANRRGVPPLFCAARQGH-WQVVRLLLDRGCDVNLSDKQGRTPLMVASC--EGHLSTVEFLLSKG 1158
Cdd:PHA03095    63 KDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINPKVIRLLLRKG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1159 AALSSLDKEGLSALSwACLKGHRA---VVQYLVEEGAEIDQTDKNGRTPL----------------------DLAAFYGD 1213
Cdd:PHA03095   143 ADVNALDLYGMTPLA-VLLKSRNAnveLLRLLIDAGADVYAVDDRFRSLLhhhlqsfkprarivreliragcDPAATDML 221

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1214 AETVLY---------------LVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGA 1258
Cdd:PHA03095   222 GNTPLHsmatgssckrslvlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGA 281
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1042-1132 4.15e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 72.46  E-value: 4.15e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1042 GHSSVVQSLLgmaeEHEIEVNGTDTlWGETALTAAAGRGKVEICELLLERGAAvsRANRRGVPPLFCAARQGHWQVVRLL 1121
Cdd:pfam12796    8 GNLELVKLLL----ENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVKLL 80

                           90
                   ....*....|.
gi 1039761671 1122 LDRGCDVNLSD 1132
Cdd:pfam12796   81 LEKGADINVKD 91
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1172-1260 6.69e-15

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 71.69  E-value: 6.69e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1172 LSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVieHVDHSGMRPLDRAIGCRNTAVVV 1251
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVK 78


                   ....*....
gi 1039761671 1252 TLLRKGAKL 1260
Cdd:pfam12796   79 LLLEKGADI 87
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1117-1260 7.11e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 79.30  E-value: 7.11e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1117 VVRLLLDRGCDVNLSDKQGRTPL---MVASCEGHLSTVEFLLSKGAALSSLDKEGLSAL-SWACLKGHRAVVQYLVEEGA 1192
Cdd:PHA03095    29 EVRRLLAAGADVNFRGEYGKTPLhlyLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGA 108

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1193 EIDQTDKNGRTPLD--LAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNT--AVVVTLLRKGAKL 1260
Cdd:PHA03095   109 DVNAKDKVGRTPLHvyLSGFNINPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNAnvELLRLLIDAGADV 180
Ank_2 pfam12796
Ankyrin repeats (3 copies);
962-1093 1.98e-12

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 64.75  E-value: 1.98e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  962 LCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNcewsagppqpgtlrksqalqqaltaaasm 1041
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE----------------------------- 51

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1042 ghssvvqsllgmaeeheiEVNGTDTLWGETALTAAAGRGKVEICELLLERGA 1093
Cdd:pfam12796   52 ------------------HADVNLKDNGRTALHYAARSGHLEIVKLLLEKGA 85
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1286-1403 4.02e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 68.11  E-value: 4.02e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1286 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1365
Cdd:COG0457     15 GLAYRRLGRYEEAIEDYEKALELDPDD-------------AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1039761671 1366 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:COG0457     82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLA 119
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 844-1260 5.26e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 70.86  E-value: 5.26e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  844 LNRQQTMELGHHILKAhifkglskktGVSSSHLQALWIGYSTEGLSAALASLRNlytPNVKVSRLLILGGANVNYRtEVL 923
Cdd:PHA02876   112 LNKHKLDEACIHILKE----------AISGNDIHYDKINESIEYMKLIKERIQQ---DELLIAEMLLEGGADVNAK-DIY 177

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  924 NNAPILCVQSHlGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLIKKGARVDhldkKGQCALVhSALRgH 1003
Cdd:PHA02876   178 CITPIHYAAER-GNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNIN----KNDLSLL-KAIR-N 250

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1004 SDILQYLLncEWSAGPPQPGTLRKSQALQQALTAAASMghSSVVQSLLgmaeEHEIEVNGTDtLWGETALTAAAGRG-KV 1082
Cdd:PHA02876   251 EDLETSLL--LYDAGFSVNSIDDCKNTPLHHASQAPSL--SRLVPKLL----ERGADVNAKN-IKGETPLYLMAKNGyDT 321

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1083 EICELLLERGAAVSRANRRGVPPLFCAARQGHWQ-VVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAL 1161
Cdd:PHA02876   322 ENIRTLIMLGADVNAADRLYITPLHQASTLDRNKdIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADI 401

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1162 SSLDKEGLSALSWA-CLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYG-DAETVLYLVEKGAVIEHVDHSGMRPLD 1239
Cdd:PHA02876   402 EALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPLL 481

                          410       420
                   ....*....|....*....|.
gi 1039761671 1240 RAIGCRntAVVVTLLRKGAKL 1260
Cdd:PHA02876   482 IALEYH--GIVNILLHYGAEL 500
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 938-1195 1.00e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 69.31  E-value: 1.00e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  938 EEVVTLLLEFGACLDGMSENGMNALCYAAAAGH-----MKLVCLLIKKGARVDHLDKKGqcalvhsalrghSDILQYLLn 1012
Cdd:PHA03100    48 IDVVKILLDNGADINSSTKNNSTPLHYLSNIKYnltdvKEIVKLLLEYGANVNAPDNNG------------ITPLLYAI- 114

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1013 cewsagppqpgtlrksqalqqaltaAASMGHSSVVQSLLgmaeEHEIEVNgTDTLWGETALTAAA--GRGKVEICELLLE 1090
Cdd:PHA03100   115 -------------------------SKKSNSYSIVEYLL----DNGANVN-IKNSDGENLLHLYLesNKIDLKILKLLID 164

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1091 RGAAVSRANRrgvpplfcaarqghwqvVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLS 1170
Cdd:PHA03100   165 KGVDINAKNR-----------------VNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDT 227

                          250       260
                   ....*....|....*....|....*
gi 1039761671 1171 ALSWACLKGHRAVVQYLVEEGAEID 1195
Cdd:PHA03100   228 PLHIAILNNNKEIFKLLLNNGPSIK 252
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1258-1393 1.39e-11

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 64.06  E-value: 1.39e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1258 AKLGNAAWAMATSKPDILIILLQKLVEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrV 1326
Cdd:COG4783      6 ALYALAQALLLAGDYDEAEALLEKALELdpdnpeafallGEILLQLGDLDEAIVLLHEALELDPDE-------------P 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761671 1327 SLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNN 1393
Cdd:COG4783     73 EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1286-1406 1.45e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.57  E-value: 1.45e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1286 GNVMYKKGKMKEAAQRYQYALRKFPReglgedmrpfnelRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1365
Cdd:COG0457     49 GLAYLRLGRYEEALADYEQALELDPD-------------DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1039761671 1366 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEEE 1406
Cdd:COG0457    116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEK 156
Ank_2 pfam12796
Ankyrin repeats (3 copies);
936-1014 2.62e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 61.67  E-value: 2.62e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761671  936 GHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLIKKgARVDHLDkKGQCALVHSALRGHSDILQYLLNCE 1014
Cdd:pfam12796    8 GNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKG 84
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1263-1400 3.04e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.48  E-value: 3.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1263 AAWAMATSKPDILIILLQKLVEE-----------GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLN 1331
Cdd:COG3914     85 ALLLQALGRYEEALALYRRALALnpdnaealfnlGNLLLALGRLEEALAALRRALALNPDF-------------AEAYLN 151

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761671 1332 LSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLL 1400
Cdd:COG3914    152 LGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
PHA03095 PHA03095
ankyrin-like protein; Provisional
 882-1148 8.86e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.59  E-value: 8.86e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  882 GYSTEGLSAALASLRNLYTpnVKVSRLLILGGANVNYRTEVLNNApilcVQSHLG----HEEVVTLLLEFGACLDGMSEN 957
Cdd:PHA03095    78 APERCGFTPLHLYLYNATT--LDVIKLLIKAGADVNAKDKVGRTP----LHVYLSgfniNPKVIRLLLRKGADVNALDLY 151

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  958 GMNAL-CYAAAAG-HMKLVCLLIKKGARVDHLDKKGQCALVHsalrghsdILQYllncewsagppqpgtLRKSqalqqal 1035
Cdd:PHA03095   152 GMTPLaVLLKSRNaNVELLRLLIDAGADVYAVDDRFRSLLHH--------HLQS---------------FKPR------- 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1036 taaasmghSSVVQSLLgmaeEHEIEVNGTDTLwGETALTAAA--GRGKVEICELLLERGAAVSRANRRGVPPLFCAARQG 1113
Cdd:PHA03095   202 --------ARIVRELI----RAGCDPAATDML-GNTPLHSMAtgSSCKRSLVLPLLIAGISINARNRYGQTPLHYAAVFN 268

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1039761671 1114 HWQVVRLLLDRGCDVNLSDKQGRTPL--MVASCEGHL 1148
Cdd:PHA03095   269 NPRACRRLIALGADINAVSSDGNTPLslMVRNNNGRA 305
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1275-1403 1.80e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 65.78  E-value: 1.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1275 LIILLQKLVEEGNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALE 1354
Cdd:COG3914     74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPDN-------------AEALFNLGNLLLALGRLEEALAALRRALA 140

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1039761671 1355 LKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:COG3914    141 LNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNA 189
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1116-1265 1.91e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 65.29  E-value: 1.91e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1116 QVVRLLLDRGCDVNLSDK-QGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEI 1194
Cdd:PHA02878   148 EITKLLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST 227

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039761671 1195 DQTDKNGRTPLDLAAFY-GDAETVLYLVEKGAVIEHVDH-SGMRPLDRAIgcRNTAVVVTLLRKGAKLGNAAW 1265
Cdd:PHA02878   228 DARDKCGNTPLHISVGYcKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI--KSERKLKLLLEYGADINSLNS 298
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1286-1405 2.50e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 60.02  E-value: 2.50e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1286 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1365
Cdd:COG4235     24 GRAYLRLGRYDEALAAYEKALRLDPDN-------------ADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039761671 1366 RARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEE 1405
Cdd:COG4235     91 LGLAAFQQGDYAEAIAAWQKLLALLPADAPARLLEASIAE 130
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1279-1406 2.97e-10

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 60.21  E-value: 2.97e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1279 LQKLVEEGNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPK 1358
Cdd:COG4783      4 AEALYALAQALLLAGDYDEAEALLEKALELDPDN-------------PEAFALLGEILLQLGDLDEAIVLLHEALELDPD 70

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1039761671 1359 SYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEEE 1406
Cdd:COG4783     71 EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1297-1406 4.30e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.25  E-value: 4.30e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1297 EAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQF 1376
Cdd:COG4235      1 EAIARLRQALAANPND-------------AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDT 67

                           90       100       110
                   ....*....|....*....|....*....|
gi 1039761671 1377 LAALADLQEAVKLCPNNQEIKRLLARVEEE 1406
Cdd:COG4235     68 EEAEELLERALALDPDNPEALYLLGLAAFQ 97
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1073-1257 4.72e-10

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 64.89  E-value: 4.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1073 LTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHlSTVE 1152
Cdd:PLN03192   529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKH-HKIF 607

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1153 FLLSKGAALSSLDKEGlSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVD- 1231
Cdd:PLN03192   608 RILYHFASISDPHAAG-DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANt 686

                          170       180       190
                   ....*....|....*....|....*....|....*....
gi 1039761671 1232 HSGMRPLD-------RAIGCRNT------AVVVTLLRKG 1257
Cdd:PLN03192   687 DDDFSPTElrellqkRELGHSITivdsvpADEPDLGRDG 725
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1288-1395 4.72e-10

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 58.26  E-value: 4.72e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1288 VMYKKGKMKEAAQRYQYALRKFPREGlgedmrpfnelrvSLYLNLSRCRRKTNDFGLAEEFaSKALELKPKSYEAFYARA 1367
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNA-------------DALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLA 66

                           90       100
                   ....*....|....*....|....*...
gi 1039761671 1368 RAKRNSRQFLAALADLQEAVKLCPNNQE 1395
Cdd:COG3063     67 ELLLELGDYDEALAYLERALELDPSALR 94
Ank_4 pfam13637
Ankyrin repeats (many copies);
1168-1221 4.73e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 56.51  E-value: 4.73e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761671 1168 GLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLV 1221
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1275-1403 7.98e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 59.20  E-value: 7.98e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1275 LIILLQKLVEEGNVMYKKGKMKEAAQRYQYALRKFPREGLGEDMRPFNELRVSLYLNLSRCRRKTNDFGLAEEFASKALE 1354
Cdd:COG5010      3 ALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1039761671 1355 LKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:COG5010     83 LDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAAL 131
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1070-1201 2.03e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 61.93  E-value: 2.03e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1070 ETALTAAAGRGKVEICELLLERGAAVSRA-NRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1148
Cdd:PHA02875    69 ESELHDAVEEGDVKAVEELLDLGKFADDVfYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDI 148

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1039761671 1149 STVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNG 1201
Cdd:PHA02875   149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNG 201
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1260-1391 2.48e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.05  E-value: 2.48e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1260 LGNAAWAMATSKPDILIILLQKLVEEGNVMYKKGKMKEAAQRYQYALRKFPREGlgedmrpfnelrvSLYLNLSRCRRKT 1339
Cdd:COG5010     35 NNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNP-------------ELYYNLALLYSRS 101

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1340 NDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCP 1391
Cdd:COG5010    102 GDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Ank_2 pfam12796
Ankyrin repeats (3 copies);
907-988 2.69e-09

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.89  E-value: 2.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  907 RLLILGGANVNYRTEVLNNAPILCVQShlGHEEVVTLLLEFGACldGMSENGMNALCYAAAAGHMKLVCLLIKKGARVDH 986
Cdd:pfam12796   14 KLLLENGADANLQDKNGRTALHLAAKN--GHLEIVKLLLEHADV--NLKDNGRTALHYAARSGHLEIVKLLLEKGADINV 89


                   ..
gi 1039761671  987 LD 988
Cdd:pfam12796   90 KD 91
NACHT COG5635
Predicted NTPase, NACHT family domain [Signal transduction mechanisms];
511-1132 2.91e-09

Predicted NTPase, NACHT family domain [Signal transduction mechanisms];


Pssm-ID: 444362 [Multi-domain]  Cd Length: 935  Bit Score: 62.13  E-value: 2.91e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  511 FVHSIAALLCRSHQLAAYR-DLLIKEPQLQSMLSLRSCVQDPVAAFKRGVLEPLTSLRNEQKIpeeeyIILIDGLNE--A 587
Cdd:COG5635    196 LLRYLALELAERYLDAEDPiPILIELRDLAEEASLEDLLAEALEKRGGEPEDALERLLRNGRL-----LLLLDGLDEvpD 270

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  588 EFHKPDYGDTLSSFITKiipkFPTwLKLIVTVRANFQEIISALPFVKLSLDDFpDNKDIHSDLHAYVQHRVHSSQDILSN 667
Cdd:COG5635    271 EADRDEVLNQLRRFLER----YPK-ARVIITSRPEGYDSSELEGFEVLELAPL-SDEQIEEFLKKWFEATERKAERLLEA 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  668 ISLNGKadaaliskvsshlvLRSL-GSYLYLKLTLDLFQRGHlviksasykVVPVSLSELYLLQCNMkFMTQSAFDRALP 746
Cdd:COG5635    345 LEENPE--------------LRELaRNPLLLTLLALLLRERG---------ELPDTRAELYEQFVEL-LLERWDEQRGLT 400

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  747 ILN-------------VALASLH----PMTDEQIFQAINAgHIQGEQGWEDFQQRMEALSCFLIKRRDKTRMFCHPSFRE 809
Cdd:COG5635    401 IYRelsreelrellseLALAMQEngrtEFAREELEEILRE-YLGRRKDAEALLDELLLRTGLLVERGEGRYSFAHRSFQE 479

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  810 WLV-----WRADGESTAFL----CEPRNgHALLAFMFSRQESKLNRQQTMELGHHILKAHIFKGLSKKTGVSS--SHLQA 878
Cdd:COG5635    480 YLAaralvEELDEELLELLaehlEDPRW-REVLLLLAGLLDDVKQIKELIDALLARDDAAALALAAALLLALLlaLALLA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  879 LWIGYSTEGLSAALASLRNLYTPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENG 958
Cdd:COG5635    559 LLALLLLLRLLLALLALLLLALLLLLLLALLLALLALDLGLAALLLLLLLLLLLLLLLALALLLALLLLLLLLLLAELLL 638

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  959 MNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLRKSQALQQALTAA 1038
Cdd:COG5635    639 LALLALVLLSLLLASRLLLITLLLLAAASAALLLLLLLLLAELLLALLALASLLLLLLLALALALALLLLAVLLAAALDL 718

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1039 ASMGHSSVVQSLLGMAEEHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVV 1118
Cdd:COG5635    719 LLLLVLLLALLLVLALALSLLLLALALLLAGALLLESSALLAVLLASLLLALLLLSLLLLLVLLLALALLASLLLALLLL 798

                          650
                   ....*....|....
gi 1039761671 1119 RLLLDRGCDVNLSD 1132
Cdd:COG5635    799 ILLLVLLGSLLLLR 812
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1276-1406 3.12e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 3.12e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1276 IILLQKLVEE-----------GNVMYKKGKMKEAAQRYQYALrkfpreglgeDMRPFNElrvSLYLNLSRCRRKTNDFGL 1344
Cdd:COG2956     62 IRIHQKLLERdpdraeallelAQDYLKAGLLDRAEELLEKLL----------ELDPDDA---EALRLLAEIYEQEGDWEK 128

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1345 AEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEEE 1406
Cdd:COG2956    129 AIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLE 190
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1258-1395 3.14e-09

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.16  E-value: 3.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1258 AKLGNAAWAMATSKPDILIILLqklvEEGNVMYKKGKMKEAAQRYQYALRKFPReglgedmrpfnelRVSLYLNLSRCRR 1337
Cdd:COG4785     56 AALAAERIDRALALPDLAQLYY----ERGVAYDSLGDYDLAIADFDQALELDPD-------------LAEAYNNRGLAYL 118

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1039761671 1338 KTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQE 1395
Cdd:COG4785    119 LLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPE 176
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1118-1201 4.40e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.45  E-value: 4.40e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1118 VRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQT 1197
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177


                   ....
gi 1039761671 1198 DKNG 1201
Cdd:PTZ00322   178 GANA 181
Ank_4 pfam13637
Ankyrin repeats (many copies);
1102-1155 6.15e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.43  E-value: 6.15e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761671 1102 GVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLL 1155
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_4 pfam13637
Ankyrin repeats (many copies);
958-1011 8.24e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.05  E-value: 8.24e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761671  958 GMNALCYAAAAGHMKLVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLL 1011
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1056-1208 1.66e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 59.12  E-value: 1.66e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1056 EHEIEVNGTDTLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQG 1135
Cdd:PHA02878   155 SYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCG 234

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761671 1136 RTPLMVASceGHL---STVEFLLSKGA---ALSSLdkEGLSALSWAcLKGHRaVVQYLVEEGAEIDQTDKNGRTPLDLA 1208
Cdd:PHA02878   235 NTPLHISV--GYCkdyDILKLLLEHGVdvnAKSYI--LGLTALHSS-IKSER-KLKLLLEYGADINSLNSYKLTPLSSA 307
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1286-1386 3.65e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.55  E-value: 3.65e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1286 GNVMYKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1365
Cdd:COG0457     83 GLALQALGRYEEALEDYDKALELDPDD-------------AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYN 149

                           90       100
                   ....*....|....*....|.
gi 1039761671 1366 RARAKRNSRQFLAALADLQEA 1386
Cdd:COG0457    150 LGIALEKLGRYEEALELLEKL 170
Ank_4 pfam13637
Ankyrin repeats (many copies);
1071-1122 4.27e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.12  E-value: 4.27e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1071 TALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLL 1122
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1329-1403 4.72e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 56.17  E-value: 4.72e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039761671 1329 YLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:COG0457     11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1082-1168 5.44e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.99  E-value: 5.44e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1082 VEICEL-----------LLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLST 1150
Cdd:PTZ00322    84 VELCQLaasgdavgariLLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREV 163

                           90
                   ....*....|....*...
gi 1039761671 1151 VEFLLSKGAALSSLDKEG 1168
Cdd:PTZ00322   164 VQLLSRHSQCHFELGANA 181
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 900-1130 5.72e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 5.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  900 TPNVKVSRLLILGGANVNYrtEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLIK 979
Cdd:PHA02875    12 FGELDIARRLLDIGINPNF--EIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLD 89

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  980 KGARVDH-LDKKGQCALVHSALRGHSDILQYLLncEWSAGPPQPGTLRKSQAlqqaltaaasmgHSSVVQSLLGMAE--- 1055
Cdd:PHA02875    90 LGKFADDvFYKDGMTPLHLATILKKLDIMKLLI--ARGADPDIPNTDKFSPL------------HLAVMMGDIKGIElli 155

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761671 1056 EHEIEVNGTDTlWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHW-QVVRLLLDRGCDVNL 1130
Cdd:PHA02875   156 DHKACLDIEDC-CGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiDIVRLFIKRGADCNI 230
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1069-1258 5.82e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 57.31  E-value: 5.82e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1069 GETALTAAAGRGKVEICELLLERGAaVSRANRRGV-PPLFCAARQGHWQVVRLLLDRGCDVN-LSDKQGRTPLMVASCEG 1146
Cdd:PHA02875    35 GISPIKLAMKFRDSEAIKLLMKHGA-IPDVKYPDIeSELHDAVEEGDVKAVEELLDLGKFADdVFYKDGMTPLHLATILK 113

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1147 HLSTVEFLLSKGA--ALSSLDKegLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKG 1224
Cdd:PHA02875   114 KLDIMKLLIARGAdpDIPNTDK--FSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSG 191

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1039761671 1225 AVIEHVDHSG-MRPLDRAIGCRNTAVVVTLLRKGA 1258
Cdd:PHA02875   192 ANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGA 226
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1325-1403 9.69e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.89  E-value: 9.69e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1039761671 1325 RVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:COG4783      3 CAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLA 81
Ank_4 pfam13637
Ankyrin repeats (many copies);
927-978 1.22e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.97  E-value: 1.22e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1039761671  927 PILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKLVCLLI 978
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
1154-1208 1.25e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.04  E-value: 1.25e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761671 1154 LLSKG-AALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLA 1208
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_4 pfam13637
Ankyrin repeats (many copies);
1135-1188 1.57e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 49.58  E-value: 1.57e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761671 1135 GRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLV 1188
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 1082-1210 2.47e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 53.28  E-value: 2.47e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1082 VEICELLLERGAAVSRANR-RGVPPLfcaarqGHW---------QVVRLLLDRGCDVNLSDKQGRTPLMV--ASCEGHLS 1149
Cdd:PHA02859    66 VEILKFLIENGADVNFKTRdNNLSAL------HHYlsfnknvepEILKILIDSGSSITEEDEDGKNLLHMymCNFNVRIN 139

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1150 TVEFLLSKGAALSSLDKEGLSAL-SWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAF 1210
Cdd:PHA02859   140 VIKLLIDSGVSFLNKDFDNNNILySYILFHSDKKIFDFLTSLGIDINETNKSGYNCYDLIKF 201
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1069-1193 3.68e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 54.61  E-value: 3.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1069 GETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHL 1148
Cdd:PHA02875   102 GMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDI 181

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1039761671 1149 STVEFLLSKGAALSSLDKEG-LSALSWACLKGHRAVVQYLVEEGAE 1193
Cdd:PHA02875   182 AICKMLLDSGANIDYFGKNGcVAALCYAIENNKIDIVRLFIKRGAD 227
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1298-1396 3.73e-07

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 53.00  E-value: 3.73e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1298 AAQRYQYALRKFPREGLGEDMRPFNELR----VSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNS 1373
Cdd:COG4785     41 LADLALALAAAALAAAALAAERIDRALAlpdlAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLL 120

                           90       100
                   ....*....|....*....|...
gi 1039761671 1374 RQFLAALADLQEAVKLCPNNQEI 1396
Cdd:COG4785    121 GDYDAALEDFDRALELDPDYAYA 143
PHA02946 PHA02946
ankyin-like protein; Provisional
 1086-1254 4.74e-07

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 54.29  E-value: 4.74e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1086 ELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAAL-S 1162
Cdd:PHA02946    56 EELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLyyLSGTDDEVIERINLLVQYGAKInN 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1163 SLDKEGLSALsWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPL--DLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDr 1240
Cdd:PHA02946   136 SVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLH- 213

                          170
                   ....*....|....
gi 1039761671 1241 aIGCRNTAVVVTLL 1254
Cdd:PHA02946   214 -IVCSKTVKNVDII 226
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1335-1406 5.03e-07

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.40  E-value: 5.03e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1335 CRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALAdLQEAVKLCPNNQEIKRLLARVEEE 1406
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLE 71
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1069-1188 5.09e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 5.09e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1069 GETALTAAAGRGKVEICELLLERGAAVS---------RANRR-----GVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQ 1134
Cdd:cd22192     89 GETALHIAVVNQNLNLVRELIARGADVVspratgtffRPGPKnliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSL 168

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039761671 1135 GRTPLMV--------ASCEghlsTVEFLLS--KGAALSSLD----KEGLSALSWACLKGHRAVVQYLV 1188
Cdd:cd22192    169 GNTVLHIlvlqpnktFACQ----MYDLILSydKEDDLQPLDlvpnNQGLTPFKLAAKEGNIVMFQHLV 232
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1139-1220 5.24e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.52  E-value: 5.24e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1139 LMVASCE----GHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQYLVEEGAEIDQTDKNGRTPLDLAAFYGDA 1214
Cdd:PTZ00322    82 LTVELCQlaasGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFR 161


                   ....*.
gi 1039761671 1215 ETVLYL 1220
Cdd:PTZ00322   162 EVVQLL 167
Ank_4 pfam13637
Ankyrin repeats (many copies);
1201-1254 6.84e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 47.65  E-value: 6.84e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039761671 1201 GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLL 1254
Cdd:pfam13637    1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
Ank_5 pfam13857
Ankyrin repeats (many copies);
1088-1142 7.13e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 47.73  E-value: 7.13e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1039761671 1088 LLERG-AAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVA 1142
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1290-1405 1.05e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 49.22  E-value: 1.05e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1290 YKKGKMKEAAQRYQYALRKFPReglgedmrpfNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSY---EAFYAR 1366
Cdd:COG1729      4 LKAGDYDEAIAAFKAFLKRYPN----------SPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPkapDALLKL 73

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039761671 1367 ARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARVEE 1405
Cdd:COG1729     74 GLSYLELGDYDKARATLEELIKKYPDSEAAKEARARLAR 112
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1238-1408 1.46e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 1.46e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1238 LDRAIgcrntAVVVTLLRKGAKLGNAAWAMA-----TSKPDILIILLQKLVEE-----------GNVMYKKGKMKEAAQR 1301
Cdd:COG2956     92 LDRAE-----ELLEKLLELDPDDAEALRLLAeiyeqEGDWEKAIEVLERLLKLgpenahaycelAELYLEQGDYDEAIEA 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1302 YQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAALA 1381
Cdd:COG2956    167 LEKALKLDPDC-------------ARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALE 233

                          170       180
                   ....*....|....*....|....*..
gi 1039761671 1382 DLQEAVKLCPNNqEIKRLLARVEEECK 1408
Cdd:COG2956    234 LLRKALELDPSD-DLLLALADLLERKE 259
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1040-1167 1.72e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.33  E-value: 1.72e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1040 SMGHSSVVQSLLgmaeEHEIEVNGTDtLWGETALTAAAGRGKVEICELLLERgAAVSRANRRGvpPLFC-AARQGHWQVV 1118
Cdd:PLN03192   567 SKGYEDCVLVLL----KHACNVHIRD-ANGNTALWNAISAKHHKIFRILYHF-ASISDPHAAG--DLLCtAAKRNDLTAM 638

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039761671 1119 RLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAL--SSLDKE 1167
Cdd:PLN03192   639 KELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVdkANTDDD 689
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 1286-1371 3.26e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 47.68  E-value: 3.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1286 GNVMYKKGKMKEAAQRYQYALRKFPReglgedmrpfNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYA 1365
Cdd:COG1729     37 GEAYYALGDYDEAAEAFEKLLKRYPD----------SPKAPDALLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKEA 106


                   ....*.
gi 1039761671 1366 RARAKR 1371
Cdd:COG1729    107 RARLAR 112
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 900-1129 2.00e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 49.28  E-value: 2.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  900 TPNVKVSRLLILGGANVNYRTEVLNNAPILCVQSHLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMKL--VCLL 977
Cdd:PHA03100    83 TDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLkiLKLL 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  978 IKKGARVDHLDKkgqcalvhsalrghsdiLQYLLncewsagppqpgtlrksqalqqaltaaasmghssvvqsllgmaeEH 1057
Cdd:PHA03100   163 IDKGVDINAKNR-----------------VNYLL--------------------------------------------SY 181

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039761671 1058 EIEVNGTDtLWGETALTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDVN 1129
Cdd:PHA03100   182 GVPINIKD-VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
PHA02798 PHA02798
ankyrin-like protein; Provisional
 1117-1233 3.81e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 48.29  E-value: 3.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1117 VVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLL---SKGAALSSLDKEGLSALSWACLKGHRA---VVQYLVEE 1190
Cdd:PHA02798    91 IVKILIENGADINKKNSDGETPLYCLLSNGYINNLEILLfmiENGADTTLLDKDGFTMLQVYLQSNHHIdieIIKLLLEK 170

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1039761671 1191 GAEIDQ-TDKNGRTPLDLAAFYG----DAETVLYLVEKGAVIEHVDHS 1233
Cdd:PHA02798   171 GVDINThNNKEKYDTLHCYFKYNidriDADILKLFVDNGFIINKENKS 218
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1106-1258 4.06e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 48.71  E-value: 4.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1106 LFCAARQGHWQVVRLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRAVVQ 1185
Cdd:PLN03192   529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039761671 1186 YLVEEGAEIDQtdKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGA 1258
Cdd:PLN03192   609 ILYHFASISDP--HAAGDLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 1046-1223 2.26e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 46.29  E-value: 2.26e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1046 VVQSLLGMAEEHEIE---VNGTDT---LWGETALTAAAGRGKVEICELLLERGAAVSrANRRGVppLFcaarqghwqvvr 1119
Cdd:cd22194    112 IVRILLAFAEENGILdrfINAEYTeeaYEGQTALNIAIERRQGDIVKLLIAKGADVN-AHAKGV--FF------------ 176

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1120 llldrgcdvNLSDKQ-----GRTPLMVASCEGHLSTVEFLLSKGAA-LSSLDKEG---LSALSWAC--LKGHRAVVQYLV 1188
Cdd:cd22194    177 ---------NPKYKHegfyfGETPLALAACTNQPEIVQLLMEKESTdITSQDSRGntvLHALVTVAedSKTQNDFVKRMY 247

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1039761671 1189 E------EGAEIDQ-TDKNGRTPLDLAAFYGDAETVLYLVEK 1223
Cdd:cd22194    248 DmillksENKNLETiRNNEGLTPLQLAAKMGKAEILKYILSR 289
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1292-1403 2.80e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 2.80e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1292 KGKMKEAAQRYQYALRKFPReglgedmrpfnelRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKR 1371
Cdd:COG2956     21 NGQPDKAIDLLEEALELDPE-------------TVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1039761671 1372 NSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:COG2956     88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEI 119
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1105-1133 2.84e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.97  E-value: 2.84e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 1039761671 1105 PLFCAA-RQGHWQVVRLLLDRGCDVNLSDK 1133
Cdd:pfam00023    5 PLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 895-1151 4.73e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 45.24  E-value: 4.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  895 LRNLYTPNVKVSRLLI--LGGANVNYRTEVLNNAPILCVQShLGHEEVVTLLLEFGACLDGMSENGMNALCYAAAAGHMK 972
Cdd:PLN03192   494 LKNFLQHHKELHDLNVgdLLGDNGGEHDDPNMASNLLTVAS-TGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYED 572

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  973 LVCLLIKKGARVDHLDKKGQCALVHSALRGHSDILQYLLNCEWSAGPPQPGTLrksqalqqaltaaasmghssvvqsllg 1052
Cdd:PLN03192   573 CVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISDPHAAGDL--------------------------- 625

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1053 maeeheievngtdtlwgetaLTAAAGRGKVEICELLLERGAAVSRANRRGVPPLFCAARQGHWQVVRLLLDRGCDV---N 1129
Cdd:PLN03192   626 --------------------LCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVdkaN 685

                          250       260
                   ....*....|....*....|....*
gi 1039761671 1130 LSDKQGRTPL--MVASCE-GHLSTV 1151
Cdd:PLN03192   686 TDDDFSPTELreLLQKRElGHSITI 710
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 1069-1209 4.96e-04

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 45.07  E-value: 4.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1069 GETALTAAAGRGKVEICELLLERGAAVS-RAN-------------RRGVPPLFCAARQGHWQVVRLLLDRGCDVNLSDKQ 1134
Cdd:TIGR00870  128 GITALHLAAHRQNYEIVKLLLERGASVPaRACgdffvksqgvdsfYHGESPLNAAACLGSPSIVALLSEDPADILTADSL 207

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1135 GRTPLmvascegHLSTVEfllskgaALSSLDKEGLSalswaclkghRAVVQYLVEEGAEIDQTDK-------NGRTPLDL 1207
Cdd:TIGR00870  208 GNTLL-------HLLVME-------NEFKAEYEELS----------CQMYNFALSLLDKLRDSKElevilnhQGLTPLKL 263


                   ..
gi 1039761671 1208 AA 1209
Cdd:TIGR00870  264 AA 265
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1134-1166 6.24e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.81  E-value: 6.24e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039761671 1134 QGRTPLMVASCE-GHLSTVEFLLSKGAALSSLDK 1166
Cdd:pfam00023    1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1064-1240 6.41e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 44.49  E-value: 6.41e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1064 TDTLW-GETALTAAAGRGKVEICELLLERGAAVS-RANRR------------GVPPLFCAARQGHWQVVRLLLDRGCD-- 1127
Cdd:cd21882     67 TDEFYqGQTALHIAIENRNLNLVRLLVENGADVSaRATGRffrkspgnlfyfGELPLSLAACTNQEEIVRLLLENGAQpa 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1128 -VNLSDKQGRTPL--MVASCEGHLSTVEFLLSKGAALSSLDKEGLSALSWACLKGHRavvqylveegaeidqtdknGRTP 1204
Cdd:cd21882    147 aLEAQDSLGNTVLhaLVLQADNTPENSAFVCQMYNLLLSYGAHLDPTQQLEEIPNHQ-------------------GLTP 207

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1039761671 1205 LDLAAFYGDAETVLYLVEKGAviehvdHSGMRPLDR 1240
Cdd:cd21882    208 LKLAAVEGKIVMFQHILQREF------SGPYQPLSR 237
PRK09782 PRK09782
bacteriophage N4 receptor, outer membrane subunit; Provisional
 1327-1393 9.10e-04

bacteriophage N4 receptor, outer membrane subunit; Provisional


Pssm-ID: 236624 [Multi-domain]  Cd Length: 987  Bit Score: 44.14  E-value: 9.10e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039761671 1327 SLYLNLSRCRRKTNDFGLAEEFASKALELKPkSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNN 1393
Cdd:PRK09782   577 ALYWWLHAQRYIPGQPELALNDLTRSLNIAP-SANAYVARATIYRQRHNVPAAVSDLRAALELEPNN 642
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1200-1228 1.14e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.14e-03
                            10        20
                    ....*....|....*....|....*....
gi 1039761671  1200 NGRTPLDLAAFYGDAETVLYLVEKGAVIE 1228
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1101-1129 1.24e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 1.24e-03
                           10        20
                   ....*....|....*....|....*....
gi 1039761671 1101 RGVPPLFCAARQGHWQVVRLLLDRGCDVN 1129
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1134-1159 1.32e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 1.32e-03
                            10        20
                    ....*....|....*....|....*.
gi 1039761671  1134 QGRTPLMVASCEGHLSTVEFLLSKGA 1159
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGA 26
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1184-1273 1.98e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 1.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1184 VQYLVEEGAEIDQTDKNGRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNA 1263
Cdd:PTZ00322    98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177

                           90
                   ....*....|
gi 1039761671 1264 AwamATSKPD 1273
Cdd:PTZ00322   178 G---ANAKPD 184
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 1101-1130 2.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.18  E-value: 2.02e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1039761671  1101 RGVPPLFCAARQGHWQVVRLLLDRGCDVNL 1130
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1105-1238 2.45e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 42.69  E-value: 2.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1105 PLFCAARQGHWQVV-RLLLDRGCDVNLSDKQGRTPLMVASCEGHLSTVEFLLSKGAAL------SSLdKEGLSALSWACL 1177
Cdd:cd22192     20 PLLLAAKENDVQAIkKLLKCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvnepmtSDL-YQGETALHIAVV 98

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039761671 1178 KGHRAVVQYLVEEGAEIDQ----------TDKN----GRTPLDLAAFYGDAETVLYLVEKGAVIEHVDHSGMRPL 1238
Cdd:cd22192     99 NQNLNLVRELIARGADVVSpratgtffrpGPKNliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1290-1402 3.03e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 3.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1290 YKKGKMKEAAQRYQYALRKFPREglgedmrpfnelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARA 1369
Cdd:TIGR02917  510 IQEGNPDDAIQRFEKVLTIDPKN-------------LRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQY 576

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1039761671 1370 KRNSRQFLAALADLQEAVKLCPNNQEIKRLLAR 1402
Cdd:TIGR02917  577 YLGKGQLKKALAILNEAADAAPDSPEAWLMLGR 609
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1232-1404 3.59e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 3.59e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1232 HSGMRPLDRAIGCRNTAVVVTLLRKGAKLGNAAWAMATSKPDILIILLQKLVEE-----------GNVMYKKGKMKEAAQ 1300
Cdd:TIGR02917  135 YLGLGQLELAQKSYEQALAIDPRSLYAKLGLAQLALAENRFDEARALIDEVLTAdpgnvdalllkGDLLLSLGNIELALA 214

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1301 RYQYALRkfpreglgedMRPFNelrVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFYARARAKRNSRQFLAAL 1380
Cdd:TIGR02917  215 AYRKAIA----------LRPNN---IAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLAHYLKALVDFQKKNYEDAR 281

                          170       180
                   ....*....|....*....|....
gi 1039761671 1381 ADLQEAVKLCPNNQEIKRLLARVE 1404
Cdd:TIGR02917  282 ETLQDALKSAPEYLPALLLAGASE 305
TPR_14 pfam13428
Tetratricopeptide repeat;
1361-1403 3.72e-03

Tetratricopeptide repeat;


Pssm-ID: 463874 [Multi-domain]  Cd Length: 44  Bit Score: 37.02  E-value: 3.72e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039761671 1361 EAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:pfam13428    2 EALLALARALLALGDPDEALALLERALALDPDDPEAWLALAQL 44
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 1323-1403 3.86e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 41.43  E-value: 3.86e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671 1323 ELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPKSYEAFY-ARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLA 1401
Cdd:COG3071     47 EAPLLAYLLAARAAQALGDYERRDEYLAQALELAPEAELAVLlTRAELLLDQGQAEQALATLEALRAGAPRHPQVLRLLL 126


                   ..
gi 1039761671 1402 RV 1403
Cdd:COG3071    127 QA 128
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1353-1403 4.01e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 4.01e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039761671 1353 LELKPKSYEAFYARARAKRNSRQFLAALADLQEAVKLCPNNQEIKRLLARV 1403
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLA 51
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 957-985 4.43e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.43e-03
                            10        20
                    ....*....|....*....|....*....
gi 1039761671   957 NGMNALCYAAAAGHMKLVCLLIKKGARVD 985
Cdd:smart00248    1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 957-989 5.02e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 36.11  E-value: 5.02e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039761671  957 NGMNALCYAAA-AGHMKLVCLLIKKGARVDHLDK 989
Cdd:pfam00023    1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 901-1019 6.06e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 41.40  E-value: 6.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039761671  901 PNVKVSRLLILGGANVNYrTEVLNNAPILCVQSHlGHEEVVTLLLEFGACLDGMSENGMNALCYAAAA-GHMKLVCLLIK 979
Cdd:PHA02878   179 KDQRLTELLLSYGANVNI-PDKTNNSPLHHAVKH-YNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLE 256

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039761671  980 KGARVDHLDKKGQCALVHSALRGhSDILQYLLncEWSAGP 1019
Cdd:PHA02878   257 HGVDVNAKSYILGLTALHSSIKS-ERKLKLLL--EYGADI 293
TPR_12 pfam13424
Tetratricopeptide repeat;
1286-1358 6.42e-03

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 37.37  E-value: 6.42e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039761671 1286 GNVMYKKGKMKEAAQRYQYALRKFpREGLGEDmrpfNELRVSLYLNLSRCRRKTNDFGLAEEFASKALELKPK 1358
Cdd:pfam13424   10 AAVLRRLGRYDEALELLEKALEIA-RRLLGPD----HPLTATTLLNLGRLYLELGRYEEALELLERALALAEK 77
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1200-1232 7.22e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 7.22e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039761671 1200 NGRTPLDLAA-FYGDAETVLYLVEKGAVIEHVDH 1232
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1069-1100 7.51e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.73  E-value: 7.51e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039761671 1069 GETALTAAAGR-GKVEICELLLERGAAVSRANR 1100
Cdd:pfam00023    2 GNTPLHLAAGRrGNLEIVKLLLSKGADVNARDK 34
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1167-1195 9.18e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 35.31  E-value: 9.18e-03
                           10        20
                   ....*....|....*....|....*....
gi 1039761671 1167 EGLSALSWACLKGHRAVVQYLVEEGAEID 1195
Cdd:pfam13606    1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_4 pfam13637
Ankyrin repeats (many copies);
1042-1089 9.57e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 36.10  E-value: 9.57e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1039761671 1042 GHSSVVQSLLgmaeEHEIEVNGTDtLWGETALTAAAGRGKVEICELLL 1089
Cdd:pfam13637   12 GHLELLRLLL----EKGADINAVD-GNGETALHFAASNGNVEVLKLLL 54
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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