RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575  91 LFGTELSCIYHEGKWPKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEELDLKKFSVHEVAWILKEFLGHI 170
Cdd:cd04402     1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 171 KGCVLTSTLYEQWLDVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWLP 250
Cdd:cd04402    81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPP 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039764575 251 SYRKV-INDIDQKISLITFMIENSPEIFGID 280
Cdd:cd04402   161 ASSELqNEDLKKVTSLVQFLIENCQEIFGED 191

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575  91 LFGTELSCIYHEGKWPKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEELDLKKFSVHEVAWILKEFLGHI 170
Cdd:cd04402     1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 171 KGCVLTSTLYEQWLDVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWLP 250
Cdd:cd04402    81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPP 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039764575 251 SYRKV-INDIDQKISLITFMIENSPEIFGID 280
Cdd:cd04402   161 ASSELqNEDLKKVTSLVQFLIENCQEIFGED 191

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575  106 PKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEELDLK--KFSVHEVAWILKEFLGHIKGCVLTSTLYEQW 183
Cdd:smart00324   4 PIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDPDLDlsEYDVHDVAGLLKLFLRELPEPLITYELYEEF 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575  184 LDVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWLP-SYRKVINDIDQK 262
Cdd:smart00324  84 IEAAKLEDETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSEENKMTARNLAIVFGPTLLRPPdGEVASLKDIRHQ 163

                          170
                   ....*....|.
gi 1039764575  263 ISLITFMIENS 273
Cdd:smart00324 164 NTVIEFLIENA 174

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575  91 LFGTELSCIYHEGKWPKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEELDLKKFSVHEVAWILKEFLGHI 170
Cdd:cd04402     1 LFGQPLSNICEDDNLPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAEPVLLLASVLKDFLRNI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 171 KGCVLTSTLYEQWLDVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWLP 250
Cdd:cd04402    81 PGSLLSSDLYEEWMSALDQENEEEKIAELQRLLDKLPRPNVLLLKHLICVLHNISQNSETNKMDAFNLAVCIAPSLLWPP 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1039764575 251 SYRKV-INDIDQKISLITFMIENSPEIFGID 280
Cdd:cd04402   161 ASSELqNEDLKKVTSLVQFLIENCQEIFGED 191

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 106 PKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEE--LDLKKFSVHEVAWILKEFLGHIKGCVLTSTLYEQW 183
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDvdLDLEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039764575 184 LDVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWLPS 251
Cdd:pfam00620  81 IEAAKLPDEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDVNKMNAHNLAIVFGPTLLRPPD 148

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 114 SVIRKQGPSTEGIFVIAPEETSCKALKEKLESGE-ELDLKKF--SVHEVAWILKEFLGHIKGCVLTSTLYEQWLDVPNKV 190
Cdd:cd04386    29 MCLLETGMNEEGLFRVGGGASKLKRLKAALDAGTfSLPLDEFysDPHAVASALKSYLRELPDPLLTYNLYEDWVQAANKP 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 191 NNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWLP----SYRKVINDIDQKISLI 266
Cdd:cd04386   109 DEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDENKMSPSNIAIVLAPNLLWAKnegsLAEMAAGTSVHVVAIV 188

                         170
                  ....*....|.
gi 1039764575 267 TFMIENSPEIF 277
Cdd:cd04386   189 ELIISHADWFF 199

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 106 PKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEELDLKKF-SVHEVAWILKEFLGHIKGCVLTSTLYEQWL 184
Cdd:cd04404    24 PPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYeDVHLPAVILKTFLRELPEPLLTFDLYDDIV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 185 DVPNkVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWLPSYRKVINDIDQKIS 264
Cdd:cd04404   104 GFLN-VDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQNKMTNSNLAVVFGPNLLWAKDASMSLSAINPINT 182

                         170
                  ....*....|...
gi 1039764575 265 LITFMIENSPEIF 277
Cdd:cd04404   183 FTKFLLDHQDEIF 195

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 108 LIVD-ILSVIRKQGPSTEGIFVIAPEETSCKALKEKLES---GEELDLKKFSVHEVAWILKEFLGHIKGCVLTSTLYEQW 183
Cdd:cd04385    17 VIVDkCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKdarSVQLREGEYTVHDVADVLKRFLRDLPDPLLTSELHAEW 96

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039764575 184 LDVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNIstgiasSILWLPS 251
Cdd:cd04385    97 IEAAELENKDERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDENQMSVHNL------ALVFGPT 158

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 101 HEGKWPKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEELDL-KKFSVHEVAWILKEFLGHIKGCVLTSTL 179
Cdd:cd04376     5 IARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLdENHSVHDVAALLKEFFRDMPDPLLPREL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 180 YEQWLDVpNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSS-----------SINKMKPYNISTGIASSILW 248
Cdd:cd04376    85 YTAFIGT-ALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAadsidedgqevSGNKMTSLNLATIFGPNLLH 163

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1039764575 249 L--PSYRKV------INDIDQKISLITFMIENSPEIFGI 279
Cdd:cd04376   164 KqkSGEREFvqaslrIEESTAIINVVQTMIDNYEELFMV 202

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 123 TEGIFVIAPEETSCKALKEKLES----GEELDLKKFSVHEVAWILKEFLGHIKGCVLTSTLYEQW--------------L 184
Cdd:cd04396    50 VEGIFRVAGSSKRIRELQLIFSTppdyGKSFDWDGYTVHDAASVLRRYLNNLPEPLVPLDLYEEFrnplrkrprilqymK 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 185 DVPNKVNNKDKLRAVKS---LLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWLPSYRKVINDIDQ 261
Cdd:cd04396   130 GRINEPLNTDIDQAIKEyrdLITRLPNLNRQLLLYLLDLLAVFARNSDKNLMTASNLAAIFQPGILSHPDHEMDPKEYKL 209

                         170
                  ....*....|..
gi 1039764575 262 KISLITFMIENS 273
Cdd:cd04396   210 SRLVVEFLIEHQ 221

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 124 EGIFVIAPEETSCKALKEKLESGEELDL----KKFSVHEVAWILKEFLGHIKGCVLTSTLYEQWLDVPNK-VNNKDKLRA 198
Cdd:cd04400    42 EGIFRLSGSASVIKQLKERFNTEYDVDLfsssLYPDVHTVAGLLKLYLRELPTLILGGELHNDFKRLVEEnHDRSQRALE 121

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1039764575 199 VKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNI 238
Cdd:cd04400   122 LKDLVSQLPQANYDLLYVLFSFLRKIIEHSDVNKMNLRNV 161

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 106 PKLIVDILSVIRKQGPSTEGIFviaPEETSCKALKEKLE-----SGEELDLKKFSVHEVAWILKEFLGHIKGCVLTSTLY 180
Cdd:cd04397    28 PALIDDIISAMRQMDMSVEGVF---RKNGNIRRLKELTEeidknPTEVPDLSKENPVQLAALLKKFLRELPDPLLTFKLY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 181 EQWLdVPNKVNNKD-KLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSI-----NKMKPYNISTGIASSILWLPSYRK 254
Cdd:cd04397   105 RLWI-SSQKIEDEEeRKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSSFSHIdeetgSKMDIHNLATVITPNILYSKTDNP 183

                         170       180
                  ....*....|....*....|...
gi 1039764575 255 VINDIDQ-KISLITFMIENSPEI 276
Cdd:cd04397   184 NTGDEYFlAIEAVNYLIENNEEF 206

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575  92 FGTELSCIYHEGKW-PKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLES-GEELDLKKFSVHEVAWILKEFLGH 169
Cdd:cd04406     1 FGVELSRLTSEDRSvPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTdANSVNLDDYNIHVIASVFKQWLRD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 170 IKGCVLTSTLYEQWLDVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWL 249
Cdd:cd04406    81 LPNPLMTFELYEEFLRAMGLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEETNRMSANALAIVFAPCILRC 160

                         170       180
                  ....*....|....*....|..
gi 1039764575 250 PSYRKVINDIdQKISLITFMIE 271
Cdd:cd04406   161 PDTTDPLQSV-QDISKTTTCVE 181

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 106 PKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLES-GEELDLKKFSVHEVAWILKEFLGHIKGCVLTSTLYEQWL 184
Cdd:cd04375    21 PRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESsTDNVNYDGQQAYDVADMLKQYFRDLPEPLLTNKLSETFI 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 185 DVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNISTGIASSILWLPSYRK 254
Cdd:cd04375   101 AIFQYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAANSQENQMTATNLAVCLAPSLFHLNTSRR 170

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 106 PKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEEL-DLKKFSVHEVAWILKEFLGHIKGCVLTSTLYEQWL 184
Cdd:cd04378    17 PFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLvELSELSPHDISSVLKLFLRQLPEPLILFRLYNDFI 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039764575 185 DVPN---KVNNKDK-----------LRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNIstGI 242
Cdd:cd04378    97 ALAKeiqRDTEEDKapntpievnriIRKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEENKMSPNNL--GI 166

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575  92 FGTELSCI--YHEGKWPKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEEL-DLKKFSVHEVAWILKEFLG 168
Cdd:cd04408     1 FGVDFSQLprDFPEEVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLvDLSGHSPHDITSVLKHFLK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 169 HIKGCVLTSTLYEQWLDVPNKVNN------------KDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPY 236
Cdd:cd04408    81 ELPEPVLPFQLYDDFIALAKELQRdsekaaespsivENIIRSLKELLGRLPVSNYNTLRHLMAHLYRVAERFEDNKMSPN 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1039764575 237 NISTGIASSILWLPSYRKV----INDIDQKISLITFMIEN 272
Cdd:cd04408   161 NLGIVFGPTLLRPLVGGDVsmicLLDTGYQAQLVEFLISN 200

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575  94 TELSCIYHEGKWPKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEELDLKKFSVHEVAWILKEFLGHIKGC 173
Cdd:cd04381     9 VERSRCHDGIDLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEEYEPPTVASLLKQYLRELPEP 88

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1039764575 174 VLTSTLYEQWLDVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNIST 240
Cdd:cd04381    89 LLTKELMPRFEEACGRPTEAEREQELQRLLKELPECNRLLLAWLIVHMDHVIAQELETKMNIQNISI 155

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575  90 KLFGTELSCIYHEG--KWPKLIVDILSVIRKQGpSTEGIFVIAPEETSCKALKEKLESGEELDLKKFS----VHEVAWIL 163
Cdd:cd04384     1 RVFGCDLTEHLLNSgqDVPQVLKSCTEFIEKHG-IVDGIYRLSGIASNIQRLRHEFDSEQIPDLTKDVyiqdIHSVSSLC 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 164 KEFLGHIKGCVLTSTLYEQWLDVPNKVNNKDKLRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNIstgia 243
Cdd:cd04384    80 KLYFRELPNPLLTYQLYEKFSEAVSAASDEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKYCSITNMHAKNL----- 154

                  ....*..
gi 1039764575 244 sSILWLP 250
Cdd:cd04384   155 -AIVWAP 160

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 120 GPSTEGIFVIAPEETSCKALKEKLESGEELDLKKFSVHEVAWILKEFLGHIKGCVLTSTLYEQWLDvpnkvnNKDKLRAV 199
Cdd:cd04389    37 GFQTEGIFRVPGDIDEVNELKLRVDQWDYPLSGLEDPHVPASLLKLWLRELEEPLIPDALYQQCIS------ASEDPDKA 110

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1039764575 200 KSLLDKLPLENAALLGNLFRILHTIASSSSI--NKMKPYNISTGIASSIL 247
Cdd:cd04389   111 VEIVQKLPIINRLVLCYLINFLQVFAQPENVahTKMDVSNLAMVFAPNIL 160

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039764575 106 PKLIVDILSVIRKQGPSTEGIFVIAPEETSCKALKEKLESGEEL-DLKKFSVHEVAWILKEFLGHIKGCVLTSTLYEQWL 184
Cdd:cd04409    17 PFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLvELSELSPHDISNVLKLYLRQLPEPLILFRLYNEFI 96

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039764575 185 DVPNKVNNKDK----------------------LRAVKSLLDKLPLENAALLGNLFRILHTIASSSSINKMKPYNI 238
Cdd:cd04409    97 GLAKESQHVNEtqeakknsdkkwpnmctelnriLLKSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEENKMSASNL 172