Zinc-finger double domain;

                          10        20
                  ....*....|....*....|....*
gi 1039767189 379 LKRHIRSHTGERPYPCETCGKRFTR 403
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  47 LNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYIQDSGRhSTASLDIVTSDAFSTILDFLYSGKLdLCGE 126
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSV-SEITLDDVSPEDFEALLEFMYTGKL-ISEE 78

                          90       100
                  ....*....|....*....|....*....
gi 1039767189 127 NVIEVMSAASYLQMNEVVNFCKTYIRSSL 155
Cdd:pfam00651  79 NVDDLLAAADKLQIPSLVDKCEEFLIKSL 107

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  56 FCDCSIIVE--GRIFKAHRNILFANSGYFRALllhyIQDSGRHSTASLDIvTSDAFSTILDFLYSGKLDLCGENVIEVMS 133
Cdd:PHA03098    9 FCDESIIIVngGGIIKVHKIILSSSSEYFKKM----FKNNFKENEINLNI-DYDSFNEVIKYIYTGKINITSNNVKDILS 83

                          90       100
                  ....*....|....*....|....
gi 1039767189 134 AASYLQMNEVVNFCKTYIRSSLDI 157
Cdd:PHA03098   84 IANYLIIDFLINLCINYIIKIIDD 107

C2H2-type zinc-finger domain;

                          10        20
                  ....*....|....*....|....*
gi 1039767189 364 HRCPFCPYTAKQKGILKRHIRSHTG 388
Cdd:pfam13909   1 YKCSQCDYSTAWKSNLKRHLRKHTG 25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  39 YCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYIQDSGRHSTASLDIVTSDAFSTILDFLYS 118
Cdd:cd18199     1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLSHYIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039767189 119 GKLDLCGENVIEVMSAASYLQMNEVVNFCKTYI 151
Cdd:cd18199    81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  38 SYCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYIQDSGRHSTAS-LDIVTSDAFSTILDFL 116
Cdd:cd18201     3 SYCYQLLQELNEQRKKGILCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTTVThLDVVAVQGFSVILDFM 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1039767189 117 YSGKLDLCGENVIEVMSAASYLQMNEVVNFCKTYIRSSLD 156
Cdd:cd18201    83 YSGNLVLTSQNAIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  39 YCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRAlllhYIQDSGrHSTASLD--IVTSDAFSTILDFL 116
Cdd:cd18217     1 HCEQLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGA----QYKDTE-DNIVFLDqsQVSADGFQKLLEFI 75

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039767189 117 YSGKLDLCGENVIEVMSAASYLQMNEVVNFCKT 149
Cdd:cd18217    76 YTGNLNLDSWNVAEIHQAASYLGMEEVVAKCKI 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  56 FCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYIQDSgRHSTASLDIVTSDAFSTILDFLYSGKLDLCGENVIEVMSAA 135
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKES-SSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAA 79

                  ...
gi 1039767189 136 SYL 138
Cdd:cd18186    80 DKL 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  41 AKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRalLLHYIQDSGRHSTASL--DIVTSDAFSTILDFLYS 118
Cdd:cd18956     8 GRLLGRLRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFH--LFYRDRPAGGRDTVRLngDIVTAPAFGRLLDFMYE 85

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1039767189 119 GKLDLCGENVIEVMSAASYLQMNEVVNFCKTYIR 152
Cdd:cd18956    86 GRLDLRSLPVEDVLAAASYLHMYDIVKVCKGRLR 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  38 SYCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHyiqdsGRHSTASLDIVTSDAFSTILDFLY 117
Cdd:cd18334     3 NHAKQLLLQLNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLH-----DNLINLDTDMVNPTVFRQILDFIY 77

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1039767189 118 SGKL---DLCGE-NVIEVMSAASYLQMNEVVNFCKTYIR 152
Cdd:cd18334    78 TGKLltsDQPGEqNFNALLTAASYLQLHDLAALCRKKLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  42 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHyiqdsgRHSTASLDIVTSDAFSTILDFLYSGKL 121
Cdd:cd18206     8 HVLEQLNQQRQLGLLCDCTFVVDGVDFKAHKAVLAACSEYFRMLFVD------QKDVVHLDISNAAGLGQVLEFMYTAKL 81

                          90       100       110
                  ....*....|....*....|....*....|
gi 1039767189 122 DLCGENVIEVMSAASYLQMNEVVNFCKTYI 151
Cdd:cd18206    82 SLSPENVDDVLAVATFLQMQDIVTACHALK 111

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189   58 DCSIIVEGRIFKAHRNILFANSGYFRALLLHyIQDSGRHSTASLDIVTSDAFSTILDFLYSGKLDLCGENVIEVMSAASY 137
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSS-DFKESDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*...
gi 1039767189  138 LQMNEVVNFCKTYIRSSL 155
Cdd:smart00225  80 LQIPGLVELCEEFLLKLL 97

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  42 KLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRalLLHYIQDSGRHSTA-SLDIVTSDAFSTILDFLYSGK 120
Cdd:cd18323     9 HLLQSLREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFH--MFYKEQLDKRDLVCiNNEIVTAPAFSLLLEFMYEGR 86

                          90       100
                  ....*....|....*....|....*...
gi 1039767189 121 LDLCGENVIEVMSAASYLQMNEVVNFCK 148
Cdd:cd18323    87 LSFNDTPVEDVLAAASYLHMNDIVKVCK 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  41 AKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHyiqDSGRHS--TASLDIVTSDAFSTILDFLYS 118
Cdd:cd18306     3 ESVLAKLNALRKNRQFCDVILQVGGHEIPAHRAVLACASPYLFELFSS---DSDGESilTVKLDGLDPDAVEVLVNYAYT 79

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1039767189 119 GKLDLCGENVIEVMSAASYLQMNEVVNFCKTYIRSSLD 156
Cdd:cd18306    80 SRLEVPADLVKSVYSAAKKLKMDRVKKACGDFLLEKLT 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  43 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHyiQDSGRHSTASLDIVTSDAFSTILDFLYSGKLD 122
Cdd:cd18233     5 LLQQLHEQRIQGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQN--SSSQKNDVFHLDIKNVGGIGQILDFMYTSHLD 82

                          90       100       110
                  ....*....|....*....|....*....|
gi 1039767189 123 LCGENVIEVMSAASYLQMNEVVNFCKTYIR 152
Cdd:cd18233    83 LNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  43 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRallLHYIQDSGRHSTASL--DIVTSDAFSTILDFLYSGK 120
Cdd:cd18324    10 LLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFH---LFYKDQLDKRDIVHLnsDIVTAPAFALLLEFMYEGK 86

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039767189 121 LDLCGENVIEVMSAASYLQMNEVVNFCKTYIR 152
Cdd:cd18324    87 LQFKDLPIEDVLAAASYLHMYDIVKVCKKKLK 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  37 QSYCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYIQDSGRhSTASLDIVTSDAFSTILDFL 116
Cdd:cd18264     9 KSHGEAVLSQYQSLRAEGFLCDVVLEAEGNEFPAHRSLLACSSDYFRALFKDYTQESKA-RVIHLPVVSAAGLQRVLDFI 87

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1039767189 117 YSGKLDLCGENVIEVMSAASYLQMNEVVNFCKTYIRSSLD 156
Cdd:cd18264    88 YTSWLSLSLDTLEDTLEAASYLQVTEAIGLCSQYLINNLA 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  43 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRAlllhYIQDSGRHSTASLDI---VTSDAFSTILDFLYSG 119
Cdd:cd18215     6 VLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYS----IFTDQLKNNVSVINLdpeIEPEGFRILLDFMYTS 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039767189 120 KLDLCGENVIEVMSAASYLQMNEVVNFCKTYI 151
Cdd:cd18215    82 RLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  39 YCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLlhyIQDSGRHSTASL-DIVTSDAFSTILDFLY 117
Cdd:cd18278    14 HCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQAL---VGQTENDLVVSLpEEVTARGFGPLLQFAY 90

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1039767189 118 SGKLDLCGENVIEVMSAASYLQMNEVVNFCKTYI 151
Cdd:cd18278    91 TAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  41 AKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYIQDSgRHSTASLDIVTSDAFSTILDFLYSGK 120
Cdd:cd18237     6 ADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTES-KSSEVELKDAEPDIIELLVEFAYTAR 84

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1039767189 121 LDLCGENVIEVMSAASYLQMNEVVNFCKTYIRSSLD 156
Cdd:cd18237    85 ISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLD 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  39 YCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYIQDSGRHSTASLDIVTSDAFSTILDFLYS 118
Cdd:cd18202     2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIEKGAVSSHEAVVDLSGFCKSSFLPLLEFAYT 81

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1039767189 119 GKL--DLCgeNVIEVMSAASYLQMNEVVNFCK 148
Cdd:cd18202    82 SELtfDFC--SMAEVAMLARHLFMNEVLEICE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  43 LLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLhyiqDSGRHSTASLDI---VTSDAFSTILDFLYSG 119
Cdd:cd18332     6 VLLNLNELRKRDILTDVTLLVGGTPLRAHKAVLIACSGFFYSIFS----GRVGEGVSVLTLpsgLEARGFQLLLDFMYTS 81

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039767189 120 KLDLCGENVIEVMSAASYLQMNEVVNFCKTYIR 152
Cdd:cd18332    82 RLPLTPRTVPAVLAAATYLQMEHVVETCRRFIQ 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  39 YCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLlhyiqDSG----RHSTASLDIVTSDAFSTILD 114
Cdd:cd18326     8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLF-----TSGavvdQQNVYEIDFVSAEALTALLD 82

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039767189 115 FLYSGKLDLCGENVIEVMSAASYLQMNEVVNFC 147
Cdd:cd18326    83 FAYTATLTVSTSNVGDILSAARLLEIPAVSHVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  39 YCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLhyIQDSGRhsTASLDIVTSDAFSTILDFLYS 118
Cdd:cd18227     8 FSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVL--LKNSRR--IVLPDVMNPRVFENILLSCYT 83

                          90       100
                  ....*....|....*....|....*....
gi 1039767189 119 GKLDLCGENVIEVMSAASYLQMNEVVNFC 147
Cdd:cd18227    84 GRLVLPAPEIVSYLTAASFLQMWHVVDKC 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  39 YCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHyiQDSGRHSTASLDIVTSDAFSTILDFLYS 118
Cdd:cd18277    10 HSTNVLLSLNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVG--QADAELNITLPEEVTVKGFEPLIQFAYT 87

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1039767189 119 GKLDLCGENVIEVMSAASYLQMNEVVNFCKTYI 151
Cdd:cd18277    88 AKLILSKDNVDEVCKCVEFLSVHNIEESCFQFL 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  38 SYCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYiQDSGRHSTASLDIVTSDAFSTILDFLY 117
Cdd:cd18328     7 NHSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAG-TLADQPYVYEIDFVTPEALSAILEFAY 85

                          90       100       110
                  ....*....|....*....|....*....|
gi 1039767189 118 SGKLDLCGENVIEVMSAASYLQMNEVVNFC 147
Cdd:cd18328    86 TSTLTITTSNVKHILNAAQMLEIQCIINVC 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039767189  37 QSYCAKLLGELNEQRKRDFFCDCSIIVEGRIFKAHRNILFANSGYFRALLLHYIQDSGRhSTASLDIVTSDAFSTILDFL 116
Cdd:cd18268     4 QDLSSELLRQLNSLRQERILTDVILCTGDKEIPCHRNVLASSSPYFRAMFCNNFRESSQ-AKVDLKGIDSDVLDQIVDYV 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1039767189 117 YSGKLDLCGENVIEVMSAASYLQMNEVVNFCKTYIRSSL--DICRKM 161
Cdd:cd18268    83 YTGEILITRDNVLPLMEAASMLQYPKLFEACSLYLQDQLtpENCLSM 129