|
Name |
Accession |
Description |
Interval |
E-value |
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
48-350 |
2.64e-126 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 363.82 E-value: 2.64e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 48 TLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTS 127
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 128 LYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGdSMTPVSLLADpSFVRAWIGGVGDCKLGGvtrlpsrNYGPTVA 207
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKG-GEKGVSALVS-SFRRAAPGGPGAAKAGG-------NYAASLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 208 VQREAQKRGCEQVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVT 287
Cdd:cd01557 152 AQKEAAEKGYDQALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPIT 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039777056 288 MKELKRALeegrvrEVFGSGTACQVCPVHQILYEGKQlhiPTMENGPELILRFQKELKAIQYG 350
Cdd:cd01557 226 RDELYEAD------EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
|
|
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
1-360 |
1.63e-123 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 359.46 E-value: 1.63e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 1 MTKEPQKKPAPSQaLLFGKTFTDHMLMVEWNNKAgWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFR 80
Cdd:PRK13357 9 PTSDEKRAIDWAN-LGFGYVFTDHMVVIDYKDGK-WHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSIVLFR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 81 PWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWV-PDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVG 159
Cdd:PRK13357 87 PDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIASPVG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 160 SYFPGDsMTPVSLLADPSFVRAWIGGVGDCKLGGvtrlpsrNYGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNI 238
Cdd:PRK13357 167 AYFKGG-VKPVSIWVSDEYDRAAPGGTGAAKVGG-------NYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 239 F-VYwthEDGVlelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRALEEGRVREVFGSGTACQVCPVHQ 317
Cdd:PRK13357 239 FfIT---KDGT---VTPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGG 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1039777056 318 ILYEGKQLHIPTMENGPeLILRFQKELKAIQYGASA--HDWMFRV 360
Cdd:PRK13357 312 IKYKDKEFVIGDGEVGP-VTQKLYDELTGIQFGDVEdpHGWIVKV 355
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
36-360 |
1.60e-97 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 292.05 E-value: 1.60e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 36 WGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEV 115
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 116 DKDWVPD-GNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGDSmTPVSLLADPSFVRAWIGGVGDCKLGGv 194
Cdd:TIGR01123 81 NKDWVPPyGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGL-APVSIFVTTEYDRAAPGGTGAVKVGG- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 195 trlpsrNYGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNIFVYWTheDGvlELVTPPLNGVILPGVVRQSLLDLA 273
Cdd:TIGR01123 159 ------NYAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFFITG--DG--ELVTPPLSGSILPGITRDSLLQLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 274 RTWGeFRVAERKVTMKELKRALEEGrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENGpELILRFQKELKAIQYG--A 351
Cdd:TIGR01123 229 KDLG-MEVEERRIDIDELKAFVEAG--EIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGdfE 304
|
....*....
gi 1039777056 352 SAHDWMFRV 360
Cdd:TIGR01123 305 DPYGWIVEV 313
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
36-353 |
8.06e-70 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 220.06 E-value: 8.06e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 36 WGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIE 114
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 115 VDKDwvpdgngTSLYVRPVLIGNEPSLGVGMVT-QALLYVILCPVGSYFPGDSMTPVSLLADPsFVRAWIGGVGDCKlgg 193
Cdd:COG0115 79 ANGL-------EDGYIRPQVTRGVGGRGVFAEEyEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK--- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 194 vtrlpSRNYGPTVAVQREAQKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLA 273
Cdd:COG0115 148 -----TGNYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGVL--VTPPLSGGILPGITRDSVIELA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 274 RTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQIlyEGKQlhIPTMENGPeLILRFQKELKAIQYGASA 353
Cdd:COG0115 217 RELG-IPVEERPISLEELYTA------DEVFLTGTAAEVTPVTEI--DGRP--IGDGKPGP-VTRRLRELYTDIVRGEAE 284
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
61-318 |
3.91e-34 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 125.55 E-value: 3.91e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 61 QLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVDKDWVPdgngtslYVRPVLIGNEP 139
Cdd:pfam01063 1 GVFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 140 SLGV-GMVTQALLYVILCPVGSYFPGDSMTPVSLLADPSFVRAwiggvgdcklggvtRLPSRNYGPTVAVQREAQKRGCE 218
Cdd:pfam01063 69 GFGLpTSDPTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP--------------GAKTLNYLENVLARREAKAQGAD 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 219 QVLwLYGPDHQLTEVGTMNIFvyWTHEDgvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleeg 298
Cdd:pfam01063 135 DAL-LLDEDGNVTEGSTSNVF--LVKGG---TLYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA---- 203
|
250 260
....*....|....*....|
gi 1039777056 299 rvREVFGSGTACQVCPVHQI 318
Cdd:pfam01063 204 --DEAFLTNSLRGVTPVSSI 221
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BCAT_beta_family |
cd01557 |
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the ... |
48-350 |
2.64e-126 |
|
BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-ketoisovalerate. The enzyme requires pyridoxal 5'-phosphate (PLP) as a cofactor to catalyze the reaction. It has been found that mammals have two foms of the enzyme - mitochondrial and cytosolic forms while bacteria contain only one form of the enzyme. The mitochondrial form plays a significant role in skeletal muscle glutamine and alanine synthesis and in interorgan nitrogen metabolism.Members of this subgroup are widely distributed in all three forms of life.
Pssm-ID: 238798 Cd Length: 279 Bit Score: 363.82 E-value: 2.64e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 48 TLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWVPDGNGTS 127
Cdd:cd01557 1 SLHPATHALHYGQAVFEGLKAYRTPDGKIVLFRPDENAERLNRSARRLGLPPFSVEEFIDAIKELVKLDADWVPYGGGAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 128 LYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGdSMTPVSLLADpSFVRAWIGGVGDCKLGGvtrlpsrNYGPTVA 207
Cdd:cd01557 81 LYIRPFIFGTDPQLGVSPALEYLFAVFASPVGAYFKG-GEKGVSALVS-SFRRAAPGGPGAAKAGG-------NYAASLL 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 208 VQREAQKRGCEQVLWLYGPDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVT 287
Cdd:cd01557 152 AQKEAAEKGYDQALWLDGAHGYVAEVGTMNIFFVK---DG--ELITPPLDGSILPGITRDSILELARDLG-IKVEERPIT 225
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039777056 288 MKELKRALeegrvrEVFGSGTACQVCPVHQILYEGKQlhiPTMENGPELILRFQKELKAIQYG 350
Cdd:cd01557 226 RDELYEAD------EVFATGTAAVVTPVGEIDYRGKE---PGEGEVGPVTKKLYDLLTDIQYG 279
|
|
| PRK13357 |
PRK13357 |
branched-chain amino acid aminotransferase; Provisional |
1-360 |
1.63e-123 |
|
branched-chain amino acid aminotransferase; Provisional
Pssm-ID: 237363 Cd Length: 356 Bit Score: 359.46 E-value: 1.63e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 1 MTKEPQKKPAPSQaLLFGKTFTDHMLMVEWNNKAgWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFR 80
Cdd:PRK13357 9 PTSDEKRAIDWAN-LGFGYVFTDHMVVIDYKDGK-WHDARLVPYGPLELDPAATVLHYGQEIFEGLKAYRHKDGSIVLFR 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 81 PWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEVDKDWV-PDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVG 159
Cdd:PRK13357 87 PDANAKRLQRSADRLLMPELPEELFLEAVKQLVKADRDWVpPYGEGASLYLRPFMIATEPFLGVKPAEEYIFCVIASPVG 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 160 SYFPGDsMTPVSLLADPSFVRAWIGGVGDCKLGGvtrlpsrNYGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNI 238
Cdd:PRK13357 167 AYFKGG-VKPVSIWVSDEYDRAAPGGTGAAKVGG-------NYAASLLAQAEAKEKGCDQVLYLDAVEHTyIEEVGGMNF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 239 F-VYwthEDGVlelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRALEEGRVREVFGSGTACQVCPVHQ 317
Cdd:PRK13357 239 FfIT---KDGT---VTPPLSGSILPGITRDSLLQLAEDLG-LTVEERPVSIDEWQADAASGEFTEAFACGTAAVITPIGG 311
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1039777056 318 ILYEGKQLHIPTMENGPeLILRFQKELKAIQYGASA--HDWMFRV 360
Cdd:PRK13357 312 IKYKDKEFVIGDGEVGP-VTQKLYDELTGIQFGDVEdpHGWIVKV 355
|
|
| ilvE_II |
TIGR01123 |
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are ... |
36-360 |
1.60e-97 |
|
branched-chain amino acid aminotransferase, group II; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family less similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 233278 Cd Length: 313 Bit Score: 292.05 E-value: 1.60e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 36 WGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLCLPDFDKQELLECIRQLIEV 115
Cdd:TIGR01123 1 WHNGRLTPYGPLHLDPGSTVLHYGQECFEGLKAYRCADGSIVLFRPDANAARLRRSARRLLMPELPDELFLEALRQLVKA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 116 DKDWVPD-GNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGDSmTPVSLLADPSFVRAWIGGVGDCKLGGv 194
Cdd:TIGR01123 81 NKDWVPPyGSGASLYLRPFVIGTEPNLGVRPAPEYLFYVFASPVGAYFKGGL-APVSIFVTTEYDRAAPGGTGAVKVGG- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 195 trlpsrNYGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNIFVYWTheDGvlELVTPPLNGVILPGVVRQSLLDLA 273
Cdd:TIGR01123 159 ------NYAASLLAQAKAAEQGCDQVVYLDPVEHTyIEEVGAMNFFFITG--DG--ELVTPPLSGSILPGITRDSLLQLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 274 RTWGeFRVAERKVTMKELKRALEEGrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENGpELILRFQKELKAIQYG--A 351
Cdd:TIGR01123 229 KDLG-MEVEERRIDIDELKAFVEAG--EIVFACGTAAVITPVGEIQHGGKEVVFASGQPG-EVTKALYDELTDIQYGdfE 304
|
....*....
gi 1039777056 352 SAHDWMFRV 360
Cdd:TIGR01123 305 DPYGWIVEV 313
|
|
| PLPDE_IV |
cd00449 |
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, ... |
54-344 |
1.73e-78 |
|
PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate lyases (ADCL). BCAT catalyzes the reversible transamination reaction between the L-branched-chain amino and alpha-keto acids. DAAT catalyzes the synthesis of D-glutamic acid and D-alanine, and ADCL converts 4-amino-4-deoxychorismate to p-aminobenzoate and pyruvate. Except for a few enzymes, i. e., Escherichia coli and Salmonella BCATs, which are homohexamers arranged as a double trimer, the class IV PLPDEs are homodimers. Homodimer formation is required for catalytic activity.
Pssm-ID: 238254 [Multi-domain] Cd Length: 256 Bit Score: 241.35 E-value: 1.73e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 54 SGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVdkdwvpdGNGTSLYVRP 132
Cdd:cd00449 2 RGLHYGDGVFEGLRAGKG-----RLFRLDEHLDRLNRSAKRLGLPiPYDREELREALKELVAA-------NNGASLYIRP 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 133 VLIGNEPSLGVGM--VTQALLYVILCPVGSYFPGdSMTPVSLLADPSFVRAWIGGVGDCKLGgvtrlpsrNYGPTVAVQR 210
Cdd:cd00449 70 LLTRGVGGLGVAPppSPEPTFVVFASPVGAYAKG-GEKGVRLITSPDRRRAAPGGTGDAKTG--------GNLNSVLAKQ 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 211 EAQKRGCEQVLWLYGpDHQLTEVGTMNIFVYWtheDGvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKE 290
Cdd:cd00449 141 EAAEAGADEALLLDD-NGYVTEGSASNVFIVK---DG--ELVTPPLDGGILPGITRDSVIELAKELG-IKVEERPISLDE 213
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1039777056 291 LKRAleegrvREVFGSGTACQVCPVHQILYEGKqlhipTMENGPELILRFQKEL 344
Cdd:cd00449 214 LYAA------DEVFLTGTAAEVTPVTEIDGRGI-----GDGKPGPVTRKLRELL 256
|
|
| IlvE |
COG0115 |
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid ... |
36-353 |
8.06e-70 |
|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism, Coenzyme transport and metabolism]; Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 439885 [Multi-domain] Cd Length: 285 Bit Score: 220.06 E-value: 8.06e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 36 WGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIE 114
Cdd:COG0115 4 WLNGELVPEEEATISVLDRGLHYGDGVFEGIRAYDG-----RLFRLDEHLARLNRSAKRLGIPiPYTEEELLEAIRELVA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 115 VDKDwvpdgngTSLYVRPVLIGNEPSLGVGMVT-QALLYVILCPVGSYFPGDSMTPVSLLADPsFVRAWIGGVGDCKlgg 193
Cdd:COG0115 79 ANGL-------EDGYIRPQVTRGVGGRGVFAEEyEPTVIIIASPLPAYPAEAYEKGVRVITSP-YRRAAPGGLGGIK--- 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 194 vtrlpSRNYGPTVAVQREAQKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLA 273
Cdd:COG0115 148 -----TGNYLNNVLAKQEAKEAGADEALLL-DTDGYVAEGSGSNVFIV---KDGVL--VTPPLSGGILPGITRDSVIELA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 274 RTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQIlyEGKQlhIPTMENGPeLILRFQKELKAIQYGASA 353
Cdd:COG0115 217 RELG-IPVEERPISLEELYTA------DEVFLTGTAAEVTPVTEI--DGRP--IGDGKPGP-VTRRLRELYTDIVRGEAE 284
|
|
| PLN02782 |
PLN02782 |
Branched-chain amino acid aminotransferase |
17-325 |
7.69e-58 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 215418 Cd Length: 403 Bit Score: 192.76 E-value: 7.69e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 17 FGKTFTDHMLMVEWNNKAGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARRLC 96
Cdd:PLN02782 77 FGLVPTDYMYIMKCNRDGEFSKGELQRFGNIELSPSAGVLNYGQGLFEGLKAYRKEDGNILLFRPEENAIRMRNGAERMC 156
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 97 LPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPgDSMTPVSLLADP 176
Cdd:PLN02782 157 MPAPTVEQFVEAVKETVLANKRWVPPPGKGSLYIRPLLMGSGAVLGLAPAPEYTFLIYVSPVGNYFK-EGVAPINLIVEN 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 177 SFVRAWIGGVGDCKLGGvtrlpsrNYGPTVAVQREAQKRGCEQVLWLygpD--HQ--LTEVGTMNIFVYwthEDGVLElv 252
Cdd:PLN02782 236 EFHRATPGGTGGVKTIG-------NYAAVLKAQSIAKAKGYSDVLYL---DcvHKkyLEEVSSCNIFIV---KDNVIS-- 300
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039777056 253 TPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQILYEGKQL 325
Cdd:PLN02782 301 TPAIKGTILPGITRKSIIDVARSQG-FQVEERNVTVDELLEA------DEVFCTGTAVVVSPVGSITYKGKRV 366
|
|
| PLN03117 |
PLN03117 |
Branched-chain-amino-acid aminotransferase; Provisional |
15-360 |
2.23e-51 |
|
Branched-chain-amino-acid aminotransferase; Provisional
Pssm-ID: 178664 Cd Length: 355 Bit Score: 174.73 E-value: 2.23e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 15 LLFGKTFTDHMLMVEWNNKAGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARR 94
Cdd:PLN03117 25 LGFALVPTDYMYVAKCKQGESFSEGKIVPYGDISISPCAGILNYGQGLFEGLKAYRTEDGRITLFRPDQNALRMQTGADR 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 95 LCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPGDSmtPVSLLA 174
Cdd:PLN03117 105 LCMTPPSLEQFVEAVKQTVLANKKWVPPPGKGTLYIRPLLIGSGAVLGVAPAPEYTFLIYASPVGNYHKASS--GLNLKV 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 175 DPSFVRAWIGGVGDCKlggvtrlPSRNYGPTVAVQREAQKRGCEQVLWL-YGPDHQLTEVGTMNIFVYwthEDGVLElvT 253
Cdd:PLN03117 183 DHKHRRAHSGGTGGVK-------SCTNYSPVVKSLIEAKSSGFSDVLFLdAATGKNIEELSACNIFIL---KGNIVS--T 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 254 PPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENG 333
Cdd:PLN03117 251 PPTSGTILPGVTRKSISELARDIG-YQVEERDVSVDELLEA------EEVFCTGTAVVVKAVETVTFHDKKVKYRTGEEA 323
|
330 340
....*....|....*....|....*....
gi 1039777056 334 peLILRFQKELKAIQYGA--SAHDWMFRV 360
Cdd:PLN03117 324 --LSTKLHLILTNIQMGVveDKKGWMVEI 350
|
|
| PLN02883 |
PLN02883 |
Branched-chain amino acid aminotransferase |
15-360 |
1.99e-46 |
|
Branched-chain amino acid aminotransferase
Pssm-ID: 178471 Cd Length: 384 Bit Score: 162.58 E-value: 1.99e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 15 LLFGKTFTDHMLMVEWNNKAGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARR 94
Cdd:PLN02883 57 LGFSLVRTDFMFATKSCRDGNFEQGYLSRYGNIELNPAAGILNYGQGLIEGMKAYRGEDGRILLFRPELNAMRMKIGAER 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 95 LCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPgDSMTPVSLLA 174
Cdd:PLN02883 137 MCMHSPSVHQFIEGVKQTVLANRRWVPPPGKGSLYLRPLLFGSGASLGVAAAPEYTFLVFGSPVQNYFK-EGTAALNLYV 215
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 175 DPSFVRAWIGGVGDCKlggvtrlPSRNYGPTVAVQREAQKRGCEQVLWLYG-PDHQLTEVGTMNIFVYWTHedgvlELVT 253
Cdd:PLN02883 216 EEVIPRAYLGGTGGVK-------AISNYGPVLEVMRRAKSRGFSDVLYLDAdTGKNIEEVSAANIFLVKGN-----IIVT 283
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 254 PPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENG 333
Cdd:PLN02883 284 PATSGTILGGITRKSIIEIALDLG-YKVEERRVPVEELKEA------EEVFCTGTAAGVASVGSITFKNTRTEYKVGDGI 356
|
330 340
....*....|....*....|....*....
gi 1039777056 334 PELILRfqKELKAIQYGA--SAHDWMFRV 360
Cdd:PLN02883 357 VTQQLR--SILLGIQTGSiqDTKDWVLQI 383
|
|
| PLN02259 |
PLN02259 |
branched-chain-amino-acid aminotransferase 2 |
15-350 |
7.10e-45 |
|
branched-chain-amino-acid aminotransferase 2
Pssm-ID: 177901 Cd Length: 388 Bit Score: 158.35 E-value: 7.10e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 15 LLFGKTFTDHMLMVEWNNKAGWGPPRIQPFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVRLFRPWLNMDRMLRSARR 94
Cdd:PLN02259 61 LGFGLNPADYMYVMKCSKDGEFTQGELSPYGNIQLSPSAGVLNYGQAIYEGTKAYRKENGKLLLFRPDHNAIRMKLGAER 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 95 LCLPDFDKQELLECIRQLIEVDKDWVPDGNGTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGSYFPgDSMTPVSLLA 174
Cdd:PLN02259 141 MLMPSPSVDQFVNAVKQTALANKRWVPPAGKGTLYIRPLLMGSGPILGLGPAPEYTFIVYASPVGNYFK-EGMAALNLYV 219
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 175 DPSFVRAWIGGVGDCKlgGVTrlpsrNYGPTVAVQREAQKRGCEQVLWLYGPDHQ-LTEVGTMNIFVYWTHedgvlELVT 253
Cdd:PLN02259 220 EEEYVRAAPGGAGGVK--SIT-----NYAPVLKALSRAKSRGFSDVLYLDSVKKKyLEEASSCNVFVVKGR-----TIST 287
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 254 PPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQILYEGKQLHIPTMENg 333
Cdd:PLN02259 288 PATNGTILEGITRKSVMEIASDQG-YQVVEKAVHVDEVMDA------DEVFCTGTAVVVAPVGTITYQEKRVEYKTGDE- 359
|
330
....*....|....*..
gi 1039777056 334 pELILRFQKELKAIQYG 350
Cdd:PLN02259 360 -SVCQKLRSVLVGIQTG 375
|
|
| Aminotran_4 |
pfam01063 |
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to ... |
61-318 |
3.91e-34 |
|
Amino-transferase class IV; The D-amino acid transferases (D-AAT) are required by bacteria to catalyze the synthesis of D-glutamic acid and D-alanine, which are essential constituents of bacterial cell wall and are the building block for other D-amino acids. Despite the difference in the structure of the substrates, D-AATs and L-ATTs have strong similarity.
Pssm-ID: 395844 [Multi-domain] Cd Length: 221 Bit Score: 125.55 E-value: 3.91e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 61 QLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVDKDWVPdgngtslYVRPVLIGNEP 139
Cdd:pfam01063 1 GVFETLRVYNG-----KIFFLDEHLARLRRSAKLLGIPlPFDEEDLRKIIEELLKANGLGVG-------RLRLTVSRGPG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 140 SLGV-GMVTQALLYVILCPVGSYFPGDSMTPVSLLADPSFVRAwiggvgdcklggvtRLPSRNYGPTVAVQREAQKRGCE 218
Cdd:pfam01063 69 GFGLpTSDPTLAIFVSALPPPPESKKKGVISSLVRRNPPSPLP--------------GAKTLNYLENVLARREAKAQGAD 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 219 QVLwLYGPDHQLTEVGTMNIFvyWTHEDgvlELVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleeg 298
Cdd:pfam01063 135 DAL-LLDEDGNVTEGSTSNVF--LVKGG---TLYTPPLESGILPGITRQALLDLAKALG-LEVEERPITLADLQEA---- 203
|
250 260
....*....|....*....|
gi 1039777056 299 rvREVFGSGTACQVCPVHQI 318
Cdd:pfam01063 204 --DEAFLTNSLRGVTPVSSI 221
|
|
| PRK06606 |
PRK06606 |
branched-chain amino acid transaminase; |
43-318 |
1.61e-23 |
|
branched-chain amino acid transaminase;
Pssm-ID: 235841 Cd Length: 306 Bit Score: 98.68 E-value: 1.61e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 43 PFQNLTLHPACSGLHYSLQLFEGLKAYKGGDQQVrLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVdkdwvp 121
Cdd:PRK06606 17 PWEDAKVHVLTHALHYGTGVFEGIRAYDTPKGPA-IFRLREHTKRLFNSAKILRMEiPYSVDELMEAQREVVRK------ 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 122 dgNG-TSLYVRP-VLIGNEpSLGV---GMVTQALLYVIlcPVGSYFPGDSMTP-----VSlladpSFVRAwiggvgdckl 191
Cdd:PRK06606 90 --NNlKSAYIRPlVFVGDE-GLGVrphGLPTDVAIAAW--PWGAYLGEEALEKgirvkVS-----SWTRH---------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 192 gGVTRLPSR-----NYGPTVAVQREAQKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVleLVTPPLNGVILPGVVR 266
Cdd:PRK06606 150 -APNSIPTRakasgNYLNSILAKTEARRNGYDEALLL-DVEGYVSEGSGENIFIV---RDGV--LYTPPLTSSILEGITR 222
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 1039777056 267 QSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQI 318
Cdd:PRK06606 223 DTVITLAKDLG-IEVIERRITRDELYIA------DEVFFTGTAAEVTPIREV 267
|
|
| D-AAT_like |
cd01558 |
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes ... |
54-318 |
3.57e-23 |
|
D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-glutamate in addition to other D-amino acids. The enzyme like other members of this superfamily requires PLP as a cofactor. Members of this subgroup are found in all three forms of life.
Pssm-ID: 238799 [Multi-domain] Cd Length: 270 Bit Score: 97.28 E-value: 3.57e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 54 SGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCLPD-FDKQELLECIRQLIEvdKDWVPDGNGtslYVRP 132
Cdd:cd01558 19 RGFLFGDGVYEVIRVYNG-----KPFALDEHLDRLYRSAKELRIDIpYTREELKELIRELVA--KNEGGEGDV---YIQV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 133 vlignepSLGVGMV-------TQALLYVILCPVGSYFPGDSMTPVSLLADPsfVRAWiggvGDCklggvtRLPSRNYGPT 205
Cdd:cd01558 89 -------TRGVGPRghdfpkcVKPTVVIITQPLPLPPAELLEKGVRVITVP--DIRW----LRC------DIKSLNLLNN 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 206 VAVQREAQKRGCEQVlWLYGPDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERK 285
Cdd:cd01558 150 VLAKQEAKEAGADEA-ILLDADGLVTEGSSSNVFIV---KNGVL--VTPPLDNGILPGITRATVIELAKELG-IPVEERP 222
|
250 260 270
....*....|....*....|....*....|...
gi 1039777056 286 VTMKELKRAleegrvREVFGSGTACQVCPVHQI 318
Cdd:cd01558 223 FSLEELYTA------DEVFLTSTTAEVMPVVEI 249
|
|
| ilvE_I |
TIGR01122 |
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are ... |
43-318 |
3.20e-22 |
|
branched-chain amino acid aminotransferase, group I; Among the class IV aminotransferases are two phylogenetically separable groups of branched-chain amino acid aminotransferase (IlvE). The last common ancestor of the two lineages appears also to have given rise to a family of D-amino acid aminotransferases (DAAT). This model represents the IlvE family more strongly similar to the DAAT family. [Amino acid biosynthesis, Pyruvate family]
Pssm-ID: 130192 Cd Length: 298 Bit Score: 95.12 E-value: 3.20e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 43 PFQNLTLHPACSGLHYSLQLFEGLKAYKgGDQQVRLFRPWLNMDRMLRSARRLCLP-DFDKQELLECIRQLIEVDkdwvp 121
Cdd:TIGR01122 8 DWEDAKVHVLTHALHYGTGVFEGIRAYD-TDKGPAIFRLKEHIQRLYDSAKIYRMEiPYSKEELMEATRETLRKN----- 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 122 dgNGTSLYVRPVLIGNEPSLGVGMVTQAL--LYVILCPVGSYFpGDSMTPVSLLADPSFVRAwiggvgdcklGGVTRLPS 199
Cdd:TIGR01122 82 --NLRSAYIRPLVFRGDGDLGLNPRAGYKpdVIIAAWPWGAYL-GEEALEKGIDAKVSSWRR----------NAPNTIPT 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 200 R-----NYGPTVAVQREAQKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGVleLVTPPLNGVILPGVVRQSLLDLAR 274
Cdd:TIGR01122 149 AakaggNYLNSLLAKSEARRHGYDEAILL-DVEGYVAEGSGENIFIV---KDGV--LFTPPVTSSILPGITRDTVITLAK 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 1039777056 275 TWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQI 318
Cdd:TIGR01122 223 ELG-IEVVEQPISREELYTA------DEAFFTGTAAEITPIREV 259
|
|
| ADCL_like |
cd01559 |
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent ... |
55-318 |
6.65e-20 |
|
ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most members of this subgroup are likely to function as dimers. The enzyme from E.Coli, the structure of which is available, is a homodimer that is folded into a small and a larger domain. The coenzyme pyridoxal 5; -phosphate resides at the interface of the two domains that is linked by a flexible loop. Members of this subgroup are found in Eukaryotes and bacteria.
Pssm-ID: 238800 [Multi-domain] Cd Length: 249 Bit Score: 87.75 E-value: 6.65e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 55 GLHYSLQLFEGLKAYKGgdqQVRLFRPWLnmDRMLRSARRLCLPDFDKQELLECIRQLIEVDKdwVPDGngtslYVRPVL 134
Cdd:cd01559 3 GFAYGDGVFETMRALDG---RLFLLDAHL--ARLERSARRLGIPEPDLPRLRAALESLLAAND--IDEG-----RIRLIL 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 135 ignepSLGVGmvtqALLYVIL-CPVGSYFPGDSMTPVSLLADPsfVRAWIGGVGDCKLGGVTRLPSRNYGPTVAVQREAQ 213
Cdd:cd01559 71 -----SRGPG----GRGYAPSvCPGPALYVSVIPLPPAWRQDG--VRLITCPVRLGEQPLLAGLKHLNYLENVLAKREAR 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 214 KRGCEQVLWLYGPDHqLTEVGTMNIFvyWTHeDGvlELVTPPLNGVILPGVVRQSLLDLARTWGEfRVAERKVTMKELKR 293
Cdd:cd01559 140 DRGADEALFLDTDGR-VIEGTASNLF--FVK-DG--ELVTPSLDRGGLAGITRQRVIELAAAKGY-AVDERPLRLEDLLA 212
|
250 260
....*....|....*....|....*
gi 1039777056 294 AleegrvREVFGSGTACQVCPVHQI 318
Cdd:cd01559 213 A------DEAFLTNSLLGVAPVTAI 231
|
|
| PRK08320 |
PRK08320 |
branched-chain amino acid aminotransferase; Reviewed |
55-318 |
4.76e-12 |
|
branched-chain amino acid aminotransferase; Reviewed
Pssm-ID: 236238 [Multi-domain] Cd Length: 288 Bit Score: 65.66 E-value: 4.76e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 55 GLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLCL-PDFDKQELLECIRQLIEVDkdwvpdgNGTSLYVRPV 133
Cdd:PRK08320 25 GFLYGDGVFEGIRAYNG-----RVFRLKEHIDRLYDSAKAIMLeIPLSKEEMTEIVLETLRKN-------NLRDAYIRLV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 134 LignepSLGVGMV-------TQALLYVILCPVGSYfPGDsMTPVSLLADPSFVRAWIGGVGDcklggvTRLPSRNYGPTV 206
Cdd:PRK08320 93 V-----SRGVGDLgldprkcPKPTVVCIAEPIGLY-PGE-LYEKGLKVITVSTRRNRPDALS------PQVKSLNYLNNI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 207 AVQREAQKRGCEQVLWLygpDHQ--LTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAER 284
Cdd:PRK08320 160 LAKIEANLAGVDEAIML---NDEgyVAEGTGDNIFIV---KNGKL--ITPPTYAGALEGITRNAVIEIAKELG-IPVREE 230
|
250 260 270
....*....|....*....|....*....|....
gi 1039777056 285 KVTMKELKRAleegrvREVFGSGTACQVCPVHQI 318
Cdd:PRK08320 231 LFTLHDLYTA------DEVFLTGTAAEVIPVVKV 258
|
|
| PRK07544 |
PRK07544 |
branched-chain amino acid aminotransferase; Validated |
43-318 |
5.54e-11 |
|
branched-chain amino acid aminotransferase; Validated
Pssm-ID: 181025 Cd Length: 292 Bit Score: 62.69 E-value: 5.54e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 43 PFQNLTLHPACSGLHYSLQLFEGLKAYKGgdqqvRLFRPWLNMDRMLRSARRLclpDFD----KQELLECIRQLIEVdkd 118
Cdd:PRK07544 19 PWRDAKVHVLTHGLHYASSVFEGERAYGG-----KIFKLREHSERLRRSAELL---DFEipysVAEIDAAKKETLAA--- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 119 wvpdgNG-TSLYVRPVLIGNEPSLGVGMVTQALLYVILC-PVGSYF-PGDSMTPVSL-LADpsfvraWiggvgdcklggv 194
Cdd:PRK07544 88 -----NGlTDAYVRPVAWRGSEMMGVSAQQNKIHLAIAAwEWPSYFdPEAKMKGIRLdIAK------W------------ 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 195 tRLPSRNYGPTVA-----------VQREAQKRGCEQVLWLygpDH--QLTEVGTMNIFVYwthEDGVLELVTPplnGVIL 261
Cdd:PRK07544 145 -RRPDPETAPSAAkaaglymictiSKHAAEAKGYADALML---DYrgYVAEATGANIFFV---KDGVIHTPTP---DCFL 214
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*..
gi 1039777056 262 PGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQI 318
Cdd:PRK07544 215 DGITRQTVIELAKRRG-IEVVERHIMPEELAGF------SECFLTGTAAEVTPVSEI 264
|
|
| PRK07849 |
PRK07849 |
aminodeoxychorismate lyase; |
63-294 |
1.57e-09 |
|
aminodeoxychorismate lyase;
Pssm-ID: 236114 [Multi-domain] Cd Length: 292 Bit Score: 58.05 E-value: 1.57e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 63 FEGLKAYKGgdqQVRLFRPWLnmDRMLRSARRLCLPDFDKQELLECIRQLIEvdkDWvpDGNGTSLYVRPVLignepSLG 142
Cdd:PRK07849 42 FETLLVRDG---RPCNLEAHL--ERLARSAALLDLPEPDLDRWRRAVELAIE---EW--RAPEDEAALRLVY-----SRG 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 143 VGMVTQALLYVILCPVGSYFPGDSMTPVSLLADPsfvRAWIGGVGDCK---LGGVTRLpsrNYGPTVAVQREAQKRGCEQ 219
Cdd:PRK07849 107 RESGGAPTAWVTVSPVPERVARARREGVSVITLD---RGYPSDAAERApwlLAGAKTL---SYAVNMAALRYAARRGADD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 220 VlwlygpdhqltevgtmnIFvywTHEDG-VLE-------------LVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERK 285
Cdd:PRK07849 181 V-----------------IF---TSTDGyVLEgptstvviatddrLLTPPPWYGILPGTTQAALFEVAREKG-WDCEYRA 239
|
....*....
gi 1039777056 286 VTMKELKRA 294
Cdd:PRK07849 240 LRPADLFAA 248
|
|
| PRK12400 |
PRK12400 |
D-amino acid aminotransferase; Reviewed |
55-315 |
3.33e-07 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 171470 Cd Length: 290 Bit Score: 51.17 E-value: 3.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 55 GLHYSLQLFEGLKAYKGgdqQVRLFRPwlNMDRMLRSARR--LCLPdFDKQELLECIRQLIEvDKDWVPDGngtSLYVrp 132
Cdd:PRK12400 29 GLQFGDGVYEVIRLYKG---NFHLLDP--HITRLYRSMEEieLTLP-FSKAELITLLYKLIE-NNNFHEDG---TIYL-- 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 133 vlignEPSLGVGMVTQALLYVILCPVGSYfpgdsmtpVSLLADPSF-----VRA-------WIggvgDCKLggvtrlPSR 200
Cdd:PRK12400 97 -----QVSRGVQARTHTFSYDVPPTIYAY--------ITKKERPALwieygVRAisepdtrWL----RCDI------KSL 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 201 NYGPTVAVQREAQKRGCEQVLWLYgpDHQLTEVGTMNIFVYwthEDGVLelVTPPLNGVILPGVVRQSLLDLARTWgEFR 280
Cdd:PRK12400 154 NLLPNILAATKAERKGCKEALFVR--NGTVTEGSHSNFFLI---KNGTL--YTHPANHLILNGIIRQYVLSLAKTL-RIP 225
|
250 260 270
....*....|....*....|....*....|....*
gi 1039777056 281 VAERKVTMKELKRAleegrvREVFGSGTACQVCPV 315
Cdd:PRK12400 226 VQEELFSVRDVYQA------DECFFTGTTIEILPM 254
|
|
| PRK06680 |
PRK06680 |
D-amino acid aminotransferase; Reviewed |
204-325 |
4.78e-07 |
|
D-amino acid aminotransferase; Reviewed
Pssm-ID: 180656 [Multi-domain] Cd Length: 286 Bit Score: 50.70 E-value: 4.78e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 204 PTVAVQREAQKRGCeQVLWLYGpDHQLTEVGTMNIFVywTHEDGVLelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAE 283
Cdd:PRK06680 155 PNVLAKQAAKEAGA-QEAWMVD-DGFVTEGASSNAWI--VTKDGKL--VTRPADNFILPGITRHTLIDLAKELG-LEVEE 227
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 1039777056 284 RKVTMKELKRAleegrvREVFGSGTACQVCPVHQIlyEGKQL 325
Cdd:PRK06680 228 RPFTLQEAYAA------REAFITAASSFVFPVVQI--DGKQI 261
|
|
| PRK13356 |
PRK13356 |
branched-chain amino acid aminotransferase; |
83-325 |
5.10e-06 |
|
branched-chain amino acid aminotransferase;
Pssm-ID: 237362 Cd Length: 286 Bit Score: 47.64 E-value: 5.10e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 83 LNMDRMLRSARRLCL-PDFDKQELLECIRQ-LIEVDKDwvpdgngTSLYVRPVLIGNEPSLGVGMVTQALLYVILCPVGS 160
Cdd:PRK13356 52 LHCARVNRSAEALGLkPTVSAEEIEALAREgLKRFDPD-------TALYIRPMYWAEDGFASGVAPDPESTRFALCLEEA 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 161 YFPGDSMTPVSLladPSFVRAWIG-GVGDCKLGGVtrlpsrnYGPTVAVQREAQKRGCEQVLWLYGPDHqLTEVGTMNIF 239
Cdd:PRK13356 125 PMPEPTGFSLTL---SPFRRPTLEmAPTDAKAGCL-------YPNNARALREARSRGFDNALVLDMLGN-VAETATSNVF 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 240 VYwthEDGVLelVTPPLNGVILPGVVRQSLLDLARTWGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQIl 319
Cdd:PRK13356 194 MV---KDGVV--FTPVPNGTFLNGITRQRVIALLREDG-VTVVETTLTYEDFLEA------DEVFSTGNYSKVVPVTRF- 260
|
....*.
gi 1039777056 320 yEGKQL 325
Cdd:PRK13356 261 -DDRSL 265
|
|
| PLN02845 |
PLN02845 |
Branched-chain-amino-acid aminotransferase-like protein |
197-296 |
2.92e-05 |
|
Branched-chain-amino-acid aminotransferase-like protein
Pssm-ID: 215454 [Multi-domain] Cd Length: 336 Bit Score: 45.39 E-value: 2.92e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 197 LPSRNYGPTVAVQREAQKRGCEQVLWLYGpDHQLTEVGTMNI-FVywTHEDgvlELVTPPLNGvILPGVVRQSLLDLA-- 273
Cdd:PLN02845 184 VKSVNYLPNALSQMEAEERGAFAGIWLDE-EGFVAEGPNMNVaFL--TNDG---ELVLPPFDK-ILSGCTARRVLELApr 256
|
90 100
....*....|....*....|....*
gi 1039777056 274 -RTWGEFR-VAERKVTMKELKRALE 296
Cdd:PLN02845 257 lVSPGDLRgVKQRKISVEEAKAADE 281
|
|
| PRK12479 |
PRK12479 |
branched-chain-amino-acid transaminase; |
196-318 |
2.92e-04 |
|
branched-chain-amino-acid transaminase;
Pssm-ID: 183549 [Multi-domain] Cd Length: 299 Bit Score: 42.25 E-value: 2.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039777056 196 RLPSRNYGPTVAVQREAQKRGCEQVLWLyGPDHQLTEVGTMNIFVYwthEDGvlELVTPPLNGVILPGVVRQSLLDLART 275
Cdd:PRK12479 150 RIKSMNYLNNVLVKIEAAQAGVLEALML-NQQGYVCEGSGDNVFVV---KDG--KVLTPPSYLGALEGITRNSVIELCER 223
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 1039777056 276 WGeFRVAERKVTMKELKRAleegrvREVFGSGTACQVCPVHQI 318
Cdd:PRK12479 224 LS-IPCEERPFTRHDVYVA------DEVFLTGTAAELIPVVKV 259
|
|
| PRK07546 |
PRK07546 |
hypothetical protein; Provisional |
229-294 |
5.82e-04 |
|
hypothetical protein; Provisional
Pssm-ID: 169002 [Multi-domain] Cd Length: 209 Bit Score: 40.73 E-value: 5.82e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039777056 229 QLTEVGTMNIFVywthEDGVLELVTPPLNGVILPGVVRQSLLDlartwgEFRVAERKVTMKELKRA 294
Cdd:PRK07546 136 EVCEGTITNVFL----DRGGGMLTTPPLSCGLLPGVLRAELLD------AGRAREAVLTVDDLKSA 191
|
|
| |
