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Conserved domains on  [gi|1046880085|ref|XP_017447330|]
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volume-regulated anion channel subunit LRRC8A isoform X1 [Rattus norvegicus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 598.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085   1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---WVTKDSCNDSFRGWGASSP 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLespPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085  78 EPTYPNSTVLPTPDtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFV 157
Cdd:pfam12534  81 APTVSSPSASMIPE--PKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 158 SILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDK---KSSTVSEDVEATVPMLQRTKSRIEQGIVDR-SETGVLD 233
Cdd:pfam12534 159 SILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEVpSTVSVLD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 234 KKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFFLIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHP 313
Cdd:pfam12534 239 KKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHN 318

                         330       340
                  ....*....|....*....|....*..
gi 1046880085 314 LATLFKILASFYISLVIFYGLICMYTL 340
Cdd:pfam12534 319 LAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
491-772 5.08e-41

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.86  E-value: 5.08e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQ 570
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 571 KLSINNEGTKLIVLN-----SLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLK 645
Cdd:COG4886    88 GLTDLGDLTNLTELDlsgneELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 646 LWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTLLPADIGLLQNLQNLAVTANRIEALPp 725
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1046880085 726 ELFQCRKLRALHLGNNVLQSLPSrVGELTNLTQIELRGNRLECLPVE 772
Cdd:COG4886   245 ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLK 290
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 598.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085   1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---WVTKDSCNDSFRGWGASSP 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLespPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085  78 EPTYPNSTVLPTPDtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFV 157
Cdd:pfam12534  81 APTVSSPSASMIPE--PKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 158 SILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDK---KSSTVSEDVEATVPMLQRTKSRIEQGIVDR-SETGVLD 233
Cdd:pfam12534 159 SILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEVpSTVSVLD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 234 KKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFFLIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHP 313
Cdd:pfam12534 239 KKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHN 318

                         330       340
                  ....*....|....*....|....*..
gi 1046880085 314 LATLFKILASFYISLVIFYGLICMYTL 340
Cdd:pfam12534 319 LAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
491-772 5.08e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.86  E-value: 5.08e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQ 570
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 571 KLSINNEGTKLIVLN-----SLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLK 645
Cdd:COG4886    88 GLTDLGDLTNLTELDlsgneELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 646 LWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTLLPADIGLLQNLQNLAVTANRIEALPp 725
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1046880085 726 ELFQCRKLRALHLGNNVLQSLPSrVGELTNLTQIELRGNRLECLPVE 772
Cdd:COG4886   245 ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLK 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 461-768 2.08e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.21  E-value: 2.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK-EIPLWIYSLKTLEELHLTGNlsaeNNRYIVIDG 539
Cdd:PLN00113  252 IPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSN----NFTGKIPVA 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 540 LRELKRLKVLRLKSNlsKLP-QVVTDVGVH----LQKLSINNEGTKLIvlNSLKKMVNLTELELIRCDLE-RIPHSIFSL 613
Cdd:PLN00113  328 LTSLPRLQVLQLWSN--KFSgEIPKNLGKHnnltVLDLSTNNLTGEIP--EGLCSSGNLFKLILFSNSLEgEIPKSLGAC 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 614 HNLQEIDLKDNNLK-------------------------TIE----EIISFQHLH-----------------RLTCLKLW 647
Cdd:PLN00113  404 RSLRRVRLQDNSFSgelpseftklplvyfldisnnnlqgRINsrkwDMPSLQMLSlarnkffgglpdsfgskRLENLDLS 483

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 648 YNHIA-YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNNLT-LLPADIGLLQNLQNLAVTANRIEA-L 723
Cdd:PLN00113  484 RNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGeI 563

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1046880085 724 PPELFQCRKLRALHLGNNVLQ-SLPSrVGELTNLTQIELRGNRLEC 768
Cdd:PLN00113  564 PKNLGNVESLVQVNISHNHLHgSLPS-TGAFLAINASAVAGNIDLC 608
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 612-764 4.67e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 4.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 612 SLHNLQEIDLKDNNLKTIEeiiSFQHLHRLTCLKLWYNHIAYIPiQIGNLTNLERLYLNRNKIEKIpTQLFYCRKLRYLD 691
Cdd:cd21340    22 LCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV-EGLENLTNLEELH 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 692 LSHNNL------TLLPADI-GLLQNLQNLAVTANRIEALPPeLFQCRKLRALHLGNNVLQSLP---SRVGELTNLTQIEL 761
Cdd:cd21340    97 IENQRLppgeklTFDPRSLaALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDL 175


                  ...
gi 1046880085 762 RGN 764
Cdd:cd21340   176 TGN 178
LRR_8 pfam13855
Leucine rich repeat;
640-697 1.48e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.48e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 640 RLTCLKLWYNHIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNL 697
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR smart00370
Leucine-rich repeats, outliers;
661-682 8.84e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 8.84e-03
                           10        20
                   ....*....|....*....|..
gi 1046880085  661 LTNLERLYLNRNKIEKIPTQLF 682
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 598.45  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085   1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---WVTKDSCNDSFRGWGASSP 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLespPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085  78 EPTYPNSTVLPTPDtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFV 157
Cdd:pfam12534  81 APTVSSPSASMIPE--PKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 158 SILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDK---KSSTVSEDVEATVPMLQRTKSRIEQGIVDR-SETGVLD 233
Cdd:pfam12534 159 SILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEVpSTVSVLD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 234 KKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFFLIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHP 313
Cdd:pfam12534 239 KKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHN 318

                         330       340
                  ....*....|....*....|....*..
gi 1046880085 314 LATLFKILASFYISLVIFYGLICMYTL 340
Cdd:pfam12534 319 LAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
491-772 5.08e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.86  E-value: 5.08e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQ 570
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 571 KLSINNEGTKLIVLN-----SLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLK 645
Cdd:COG4886    88 GLTDLGDLTNLTELDlsgneELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 646 LWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTLLPADIGLLQNLQNLAVTANRIEALPp 725
Cdd:COG4886   166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1046880085 726 ELFQCRKLRALHLGNNVLQSLPSrVGELTNLTQIELRGNRLECLPVE 772
Cdd:COG4886   245 ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLK 290
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
503-781 4.16e-40

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 153.17  E-value: 4.16e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 503 TDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLI 582
Cdd:COG4886     8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 583 VLNSLKKMVNLTELELIRCDleriphSIFSLHNLQEIDLKDNNLKTIEEIISfqHLHRLTCLKLWYNHIAYIPIQIGNLT 662
Cdd:COG4886    88 GLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQLTDLPEPLGNLT 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTLLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNV 742
Cdd:COG4886   160 NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239

                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1046880085 743 LQSLPSrVGELTNLTQIELRGNRLECLPvELGECPLLKR 781
Cdd:COG4886   240 LTDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
517-799 3.49e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 144.69  E-value: 3.49e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 517 TLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTEL 596
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 597 ELIRCDLerIPHSIFSLHNLQEIDLKDNNlktieeiiSFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Cdd:COG4886    81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 677 IPTQLFYCRKLRYLDLSHNNLTLLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
Cdd:COG4886   151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1046880085 757 TQIELRGNRLECLPvELGECPLLKRsgLVVEEDLFSTLPPEVK 799
Cdd:COG4886   231 ETLDLSNNQLTDLP-ELGNLTNLEE--LDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
503-766 3.07e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 138.91  E-value: 3.07e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 503 TDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN--LSKLPQvvtdvgvhLQKLSINNegTK 580
Cdd:COG4886    55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNeeLSNLTN--------LESLDLSG--NQ 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 581 LIVL-NSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLKLWYNHIAYIPIQIG 659
Cdd:COG4886   125 LTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDLPEPLG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTLLPaDIGLLQNLQNLAVTANRIEALPPELfQCRKLRALHLG 739
Cdd:COG4886   203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA-NLTNLKTLDLS 280

                         250       260
                  ....*....|....*....|....*..
gi 1046880085 740 NNVLQSLPSRVGELTNLTQIELRGNRL 766
Cdd:COG4886   281 NNQLTDLKLKELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
460-775 1.70e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.13  E-value: 1.70e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 460 TIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNlsaennryiviDG 539
Cdd:COG4886    40 LSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----------EE 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 540 LRELKRLKVLRLKSN-LSKLPQVVTDVgVHLQKLSINNegTKLIVL-NSLKKMVNLTELELIRCDLERIPHSIFSLHNLQ 617
Cdd:COG4886   109 LSNLTNLESLDLSGNqLTDLPEELANL-TNLKELDLSN--NQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLK 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 618 EIDLKDNNLKTIEEiiSFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPtQLFYCRKLRYLDLSHNNL 697
Cdd:COG4886   186 ELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQL 262

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046880085 698 TLLPaDIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGE 775
Cdd:COG4886   263 TDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 461-768 2.08e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.21  E-value: 2.08e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK-EIPLWIYSLKTLEELHLTGNlsaeNNRYIVIDG 539
Cdd:PLN00113  252 IPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSN----NFTGKIPVA 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 540 LRELKRLKVLRLKSNlsKLP-QVVTDVGVH----LQKLSINNEGTKLIvlNSLKKMVNLTELELIRCDLE-RIPHSIFSL 613
Cdd:PLN00113  328 LTSLPRLQVLQLWSN--KFSgEIPKNLGKHnnltVLDLSTNNLTGEIP--EGLCSSGNLFKLILFSNSLEgEIPKSLGAC 403

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 614 HNLQEIDLKDNNLK-------------------------TIE----EIISFQHLH-----------------RLTCLKLW 647
Cdd:PLN00113  404 RSLRRVRLQDNSFSgelpseftklplvyfldisnnnlqgRINsrkwDMPSLQMLSlarnkffgglpdsfgskRLENLDLS 483

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 648 YNHIA-YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNNLT-LLPADIGLLQNLQNLAVTANRIEA-L 723
Cdd:PLN00113  484 RNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSGeI 563

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 1046880085 724 PPELFQCRKLRALHLGNNVLQ-SLPSrVGELTNLTQIELRGNRLEC 768
Cdd:PLN00113  564 PKNLGNVESLVQVNISHNHLHgSLPS-TGAFLAINASAVAGNIDLC 608
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 546-792 2.69e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 2.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 546 LKVLRLKSNL--SKLPQvvtDVGVhLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER----IPHSIFSLHNLQEI 619
Cdd:PLN00113  142 LETLDLSNNMlsGEIPN---DIGS-FSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQlvgqIPRELGQMKSLKWI 217

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 620 DLKDNNL-----KTIEEIISFQHLhrltclKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDL 692
Cdd:PLN00113  218 YLGYNNLsgeipYEIGGLTSLNHL------DLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDL 291

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 693 SHNNLT-LLPADIGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRLEcl 769
Cdd:PLN00113  292 SDNSLSgEIPELVIQLQNLEILHLFSNNFTGkIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLT-- 369

                         250       260
                  ....*....|....*....|....
gi 1046880085 770 pvelGECP-LLKRSGLVVEEDLFS 792
Cdd:PLN00113  370 ----GEIPeGLCSSGNLFKLILFS 389
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 612-764 4.67e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 72.13  E-value: 4.67e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 612 SLHNLQEIDLKDNNLKTIEeiiSFQHLHRLTCLKLWYNHIAYIPiQIGNLTNLERLYLNRNKIEKIpTQLFYCRKLRYLD 691
Cdd:cd21340    22 LCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV-EGLENLTNLEELH 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 692 LSHNNL------TLLPADI-GLLQNLQNLAVTANRIEALPPeLFQCRKLRALHLGNNVLQSLP---SRVGELTNLTQIEL 761
Cdd:cd21340    97 IENQRLppgeklTFDPRSLaALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDL 175


                  ...
gi 1046880085 762 RGN 764
Cdd:cd21340   176 TGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 627-781 2.29e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 2.29e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 627 KTIEEIISFQHLHRLTCLKLWYNHIAYIPiQIGNLTNLERLYLNRNKIEKIPtQLFYCRKLRYLDLSHNNLTLLpadIGL 706
Cdd:cd21340    12 KNITKIDNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV---EGL 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 707 --LQNLQNLAVTANRieaLPPE---LFQCRKLRA-------LHLGNNVLQSLpSRVGELTNLTQIELRGNRL---ECLPV 771
Cdd:cd21340    87 enLTNLEELHIENQR---LPPGeklTFDPRSLAAlsnslrvLNISGNNIDSL-EPLAPLRNLEQLDASNNQIsdlEELLD 162

                         170
                  ....*....|
gi 1046880085 772 ELGECPLLKR 781
Cdd:cd21340   163 LLSSWPSLRE 172
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 461-766 1.49e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.42  E-value: 1.49e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 461 IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK-EIPLWIYSLKTLEELHLT-GNLSAEnnryiVID 538
Cdd:PLN00113  180 IPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVyNNLTGP-----IPS 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 539 GLRELKRLKVLRLKSNlsklpqvvtdvgvhlqKLSinnegtklivlnslkkmvnltelelircdlERIPHSIFSLHNLQE 618
Cdd:PLN00113  255 SLGNLKNLQYLFLYQN----------------KLS------------------------------GPIPPSIFSLQKLIS 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 619 IDLKDNNLK-TIEEIISfqHLHRLTCLKLWYNHI-AYIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHN 695
Cdd:PLN00113  289 LDLSDNSLSgEIPELVI--QLQNLEILHLFSNNFtGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTN 366

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1046880085 696 NLT-LLPADIGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRL 766
Cdd:PLN00113  367 NLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 605-774 2.07e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 2.07e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 605 RIPHSIFSLHNLQEIDLKDNNLK-TIEEIIsFQHLHRLTCLKLWYNHIAYiPIQIGNLTNLERLYLNRNKIE-KIPTQLF 682
Cdd:PLN00113   84 KISSAIFRLPYIQTINLSNNQLSgPIPDDI-FTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIG 161

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 683 YCRKLRYLDLSHNNLT-LLPADIGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLG-NNVLQSLPSRVGELTNLTQI 759
Cdd:PLN00113  162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGyNNLSGEIPYEIGGLTSLNHL 241

                         170
                  ....*....|....*.
gi 1046880085 760 ELRGNRLE-CLPVELG 774
Cdd:PLN00113  242 DLVYNNLTgPIPSSLG 257
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
585-795 4.25e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.73  E-value: 4.25e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 585 NSLKKmvNLTELELIRCDLERIPHSIfsLHNLQEIDLKDNNLKTIEEiisfqHLH-RLTCLKLWYNHIAYIPIQIGNltN 663
Cdd:PRK15370  174 DCLKN--NKTELRLKILGLTTIPACI--PEQITTLILDNNELKSLPE-----NLQgNIKTLYANSNQLTSIPATLPD--T 242

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 664 LERLYLNRNKIEKIPTQL--------FYCRK-----------LRYLDLSHNNLTLLPADigLLQNLQNLAVTANRIEALP 724
Cdd:PRK15370  243 IQEMELSINRITELPERLpsalqsldLFHNKisclpenlpeeLRYLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALP 320

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046880085 725 PELFQcrKLRALHLGNNVLQSLPSRV-GELTNLtqiELRGNRLECLPVELGecPLLKRsgLVVEEDLFSTLP 795
Cdd:PRK15370  321 ETLPP--GLKTLEAGENALTSLPASLpPELQVL---DVSKNQITVLPETLP--PTITT--LDVSRNALTNLP 383
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 664-780 9.00e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 9.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 664 LERLYLNRNKIE-KIPTQLFY-CRKLRYLDLSHNNLTlLPADIGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLGN 740
Cdd:PLN00113   95 IQTINLSNNQLSgPIPDDIFTtSSSLRYLNLSNNNFT-GSIPRGSIPNLETLDLSNNMLSGeIPNDIGSFSSLKVLDLGG 173

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1046880085 741 NVLQS-LPSRVGELTNLTQIELRGNRLEC-LPVELGECPLLK 780
Cdd:PLN00113  174 NVLVGkIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLK 215
LRR_8 pfam13855
Leucine rich repeat;
640-697 1.48e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.48e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 640 RLTCLKLWYNHIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNL 697
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 515-701 2.72e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.10  E-value: 2.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 515 LKTLEELHLtgnlsaeNNRYIV-IDGLRELKRLKVLRLKSN-LSKLPQVVTDVG---VHLQklsiNNEGTKLIVLNSLKk 589
Cdd:cd21340     1 LKRITHLYL-------NDKNITkIDNLSLCKNLKVLYLYDNkITKIENLEFLTNlthLYLQ----NNQIEKIENLENLV- 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 590 mvNLTELEL----IRC--DLEriphsifSLHNLQEIDLKDNNLKTIEEII----SFQHL-HRLTCLKLWYNHIAYIpIQI 658
Cdd:cd21340    69 --NLKKLYLggnrISVveGLE-------NLTNLEELHIENQRLPPGEKLTfdprSLAALsNSLRVLNISGNNIDSL-EPL 138

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1046880085 659 GNLTNLERLYLNRNKIEKIP--TQLFY-CRKLRYLDLSHNNLTLLP 701
Cdd:cd21340   139 APLRNLEQLDASNNQISDLEelLDLLSsWPSLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
708-766 4.11e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.11e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046880085 708 QNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRL 766
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
662-720 4.58e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.58e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046880085 662 TNLERLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLTLL-PADIGLLQNLQNLAVTANRI 720
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 468-711 1.04e-06

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 52.57  E-value: 1.04e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085  468 LTGLKELWLYHTAAKIEAPALAfLRENLRALHI-KFTDIKEIPLWIYSLKTLEELHLTGNLSAENnryiVIDGLrELKRL 546
Cdd:PLN03210   633 LTGLRNIDLRGSKNLKEIPDLS-MATNLETLKLsDCSSLVELPSSIQYLNKLEDLDMSRCENLEI----LPTGI-NLKSL 706

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085  547 KVLRLK--SNLSKLPQVVTDVG---------------VHLQKL--------SINNEGTKLIVLNSLKKMVNLTELELIRC 601
Cdd:PLN03210   707 YRLNLSgcSRLKSFPDISTNISwldldetaieefpsnLRLENLdelilcemKSEKLWERVQPLTPLMTMLSPSLTRLFLS 786

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085  602 D---LERIPHSIFSLHNLQEIDLKD-NNLKTIEEIISFQHLHRLT---CLKL-WYNHIAyipiqignlTNLERLYLNRNK 673
Cdd:PLN03210   787 DipsLVELPSSIQNLHKLEHLEIENcINLETLPTGINLESLESLDlsgCSRLrTFPDIS---------TNISDLNLSRTG 857

                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1046880085  674 IEKIPTQLFYCRKLRYLDLSH-NNLTLLPADIGLLQNLQ 711
Cdd:PLN03210   858 IEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLE 896
LRR_8 pfam13855
Leucine rich repeat;
592-651 1.47e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.47e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046880085 592 NLTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEiISFQHLHRLTCLKLWYNHI 651
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 690-778 1.73e-06

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 51.74  E-value: 1.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 690 LDLSHNNLT-LLPADIGLLQNLQNLAVTANRIE-ALPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRL 766
Cdd:PLN03150  423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502

                          90
                  ....*....|...
gi 1046880085 767 EC-LPVELGECPL 778
Cdd:PLN03150  503 SGrVPAALGGRLL 515
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 476-667 6.78e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 6.78e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 476 LYHTAAKIEA-PALAFLReNLRALHIKFTDIKEIPLwIYSLKTLEELHLtgnlsaENNRYIVIDGLRELKRLKVLRLKSN 554
Cdd:cd21340     7 LYLNDKNITKiDNLSLCK-NLKVLYLYDNKITKIEN-LEFLTNLTHLYL------QNNQIEKIENLENLVNLKKLYLGGN 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 555 -------LSKLPQvvtdvgvhLQKLSINN----EGTKLIV----LNSLKKmvNLTELELIRCDLERIpHSIFSLHNLQEI 619
Cdd:cd21340    79 risvvegLENLTN--------LEELHIENqrlpPGEKLTFdprsLAALSN--SLRVLNISGNNIDSL-EPLAPLRNLEQL 147

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1046880085 620 DLKDNNLKTIEEII-SFQHLHRLTCLKLWYNHIAYIPI----QIGNLTNLERL 667
Cdd:cd21340   148 DASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKyrdkIILASKSLEVL 200
PLN03150 PLN03150
hypothetical protein; Provisional
 606-681 2.58e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 2.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046880085 606 IPHSIFSLHNLQEIDLKDNNLKTieEI-ISFQHLHRLTCLKLWYNHI-AYIPIQIGNLTNLERLYLNRNKIE-KIPTQL 681
Cdd:PLN03150  434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
645-783 1.72e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 1.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 645 KLWY--NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLfyCRKLRYldlsHNNLTLLPAdigLLQNLQNLAVTANRIEA 722
Cdd:PRK15387  286 KLWIfgNQLTSLPVLPPGLQELSVSDNQLASLPALPSEL--CKLWAY----NNQLTSLPT---LPSGLQELSVSDNQLAS 356

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1046880085 723 LPPELFQCRKLRALhlgNNVLQSLPSRVgelTNLTQIELRGNRLECLPVELGECPLLKRSG 783
Cdd:PRK15387  357 LPTLPSELYKLWAY---NNRLTSLPALP---SGLKELIVSGNRLTSLPVLPSELKELMVSG 411
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 662-697 2.03e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.54  E-value: 2.03e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1046880085 662 TNLERLYLNRNKIEKIPtQLFYCRKLRYLDLSHNNL 697
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNK 35
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 592-770 2.71e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 44.87  E-value: 2.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085  592 NLTELELIRCDLERIPHSIFSLHNLQEIDL-KDNNLKTIEEI---ISFQHLHRLTCLKLwynhiAYIPIQIGNLTNLERL 667
Cdd:PLN03210   612 NLVKLQMQGSKLEKLWDGVHSLTGLRNIDLrGSKNLKEIPDLsmaTNLETLKLSDCSSL-----VELPSSIQYLNKLEDL 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085  668 YLNR-NKIEKIPT----------QLFYCRKLR----------YLDLSHNNLTLLPADIGlLQNLQNLAVTANRIEAL--- 723
Cdd:PLN03210   687 DMSRcENLEILPTginlkslyrlNLSGCSRLKsfpdistnisWLDLDETAIEEFPSNLR-LENLDELILCEMKSEKLwer 765

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1046880085  724 -----PPELFQCRKLRALHLGNN-VLQSLPSRVGELTNLTQIELRGNR-LECLP 770
Cdd:PLN03210   766 vqpltPLMTMLSPSLTRLFLSDIpSLVELPSSIQNLHKLEHLEIENCInLETLP 819
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
616-766 4.40e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 4.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 616 LQEIDLKDNNLKTIEEIISfqhlhrlTCLKLWY--NHIAYIPI-------------QIGNL----TNLERLYLNRNKIEK 676
Cdd:PRK15387  304 LQELSVSDNQLASLPALPS-------ELCKLWAynNQLTSLPTlpsglqelsvsdnQLASLptlpSELYKLWAYNNRLTS 376

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 677 IPTqlfYCRKLRYLDLSHNNLTLLPAdigLLQNLQNLAVTANRIEALPpelFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
Cdd:PRK15387  377 LPA---LPSGLKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSE 447

                         170
                  ....*....|
gi 1046880085 757 TQIELRGNRL 766
Cdd:PRK15387  448 TTVNLEGNPL 457
PLN03150 PLN03150
hypothetical protein; Provisional
 653-734 1.48e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 1.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 653 YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNNLT-LLPADIGLLQNLQNLAVTANRIEALPPELFQC 730
Cdd:PLN03150  433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALGG 512


                  ....
gi 1046880085 731 RKLR 734
Cdd:PLN03150  513 RLLH 516
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 589-772 7.08e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.26  E-value: 7.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 589 KMVNLTELELIRCD--LERIPHSIFSLHNLQEIDLKDNNLkTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLT---- 662
Cdd:cd00116    54 KELCLSLNETGRIPrgLQSLLQGLTKGCGLQELDLSDNAL-GPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLakgl 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046880085 663 -----NLERLYLNRNKIEKIPTQ-----LFYCRKLRYLDLSHNNLT---------LLPADIGLLQ-NLQNLAVTANRIEA 722
Cdd:cd00116   133 kdlppALEKLVLGRNRLEGASCEalakaLRANRDLKELNLANNGIGdagiralaeGLKANCNLEVlDLNNNGLTDEGASA 212

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1046880085 723 LPPELFQCRKLRALHLGNNVLQS------LPSRVGELTNLTQIELRGNRLECLPVE 772
Cdd:cd00116   213 LAETLASLKSLEVLNLGDNNLTDagaaalASALLSPNISLLTLSLSCNDITDDGAK 268
LRR smart00370
Leucine-rich repeats, outliers;
661-682 8.84e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 8.84e-03
                           10        20
                   ....*....|....*....|..
gi 1046880085  661 LTNLERLYLNRNKIEKIPTQLF 682
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
661-682 8.84e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 8.84e-03
                           10        20
                   ....*....|....*....|..
gi 1046880085  661 LTNLERLYLNRNKIEKIPTQLF 682
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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