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Conserved domains on  [gi|1046888785|ref|XP_017448957|]
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G1/S-specific cyclin-E2 isoform X2 [Rattus norvegicus]

Protein Classification

cyclin family protein( domain architecture ID 1750054)

cyclin family protein may associate with and activate its cognate cyclin-dependent kinase (CDK)

CATH:  1.10.472.10
Gene Ontology:  GO:0000079|GO:0019901|GO:0007049
PubMed:  14744433|30185601|15269391|15840440
SCOP:  4001102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 100-236 4.02e-92

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20580:

Pssm-ID: 477360 [Multi-domain]  Cd Length: 137  Bit Score: 273.26  E-value: 4.02e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 100 SPLPDLSWACSQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKD 179
Cdd:cd20580     1 SPLPELSWGNSKDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046888785 180 VNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKW 236
Cdd:cd20580    81 INKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_SF super family cl40454
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 240-328 5.13e-54

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


The actual alignment was detected with superfamily member cd20582:

Pssm-ID: 477360  Cd Length: 99  Bit Score: 174.19  E-value: 5.13e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 240 PVTVISWLNLFLQVDAVKDIPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWD 319
Cdd:cd20582     1 PVTIISWLNLYLQVDSLKDHPNVLLPQYSQETFIQIAQLLDLCILDINSLDFQYRVLAAAALCHFTSFEVVKKASGLEWD 80


                  ....*....
gi 1046888785 320 DISECVDWM 328
Cdd:cd20582    81 CISECVNWM 89
 
Name Accession Description Interval E-value
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 100-236 4.02e-92

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 273.26  E-value: 4.02e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 100 SPLPDLSWACSQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKD 179
Cdd:cd20580     1 SPLPELSWGNSKDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046888785 180 VNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKW 236
Cdd:cd20580    81 INKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNE2_rpt2 cd20582
second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 240-328 5.13e-54

second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410285  Cd Length: 99  Bit Score: 174.19  E-value: 5.13e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 240 PVTVISWLNLFLQVDAVKDIPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWD 319
Cdd:cd20582     1 PVTIISWLNLYLQVDSLKDHPNVLLPQYSQETFIQIAQLLDLCILDINSLDFQYRVLAAAALCHFTSFEVVKKASGLEWD 80


                  ....*....
gi 1046888785 320 DISECVDWM 328
Cdd:cd20582    81 CISECVNWM 89
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 112-239 2.81e-51

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 168.08  E-value: 2.81e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 112 EVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGIT 191
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRF-LSKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1046888785 192 SLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWELC 239
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
117-309 9.55e-26

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 107.94  E-value: 9.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 117 MLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGITSLFIA 196
Cdd:COG5024   188 LLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRF-LSSRVVSLEKYQLVGISALFIA 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 197 SKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWELCPVTVISWLNLFLQVDavkdipkvllpQYSQETFIQIA 276
Cdd:COG5024   267 SKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKAS-----------DYDIFSRTPAK 335

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1046888785 277 QLLDLCILAIDSLEFQYRILAAAAlcHFTSIEV 309
Cdd:COG5024   336 FSSEISPVDYKFIQISPSWCAAAA--MYLSRKI 366
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 147-232 6.70e-18

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 77.63  E-value: 6.70e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785  147 DWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDgaCSEVDILKM 226
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRF-LSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 1046888785  227 ELNILK 232
Cdd:smart00385  78 ERLLLE 83
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 241-361 1.14e-10

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 58.40  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 241 VTVISWLNLFLQVDAVKDIPKVL-LPQYsqetfiqiaqLLDLCILAIDSLEFQYRILAAAALCHFTSI-------EVVKK 312
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLELRtLAKY----------LLELTLLDYDFLKYPPSLIAAAAVYLARKTlnspewtETLEH 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1046888785 313 ASGLEWDDISECVDWMvpFVSVVKSVSPVKLKTFKKIPMEDRHNIQTHT 361
Cdd:pfam02984  71 YTGYSEEDLKPCVKLL--LELLLNAPSSKLQAVRRKYSSSKFMKVSTLP 117
 
Name Accession Description Interval E-value
CYCLIN_CCNE2_rpt1 cd20580
first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 100-236 4.02e-92

first cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410283 [Multi-domain]  Cd Length: 137  Bit Score: 273.26  E-value: 4.02e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 100 SPLPDLSWACSQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKD 179
Cdd:cd20580     1 SPLPELSWGNSKDVWLNMLKKESKYVHDKHFLQLHPALQPKMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046888785 180 VNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKW 236
Cdd:cd20580    81 INKSMLQLIGITSLFIASKLEEIYPPKLHEFAYVTDGACSEDDILDMELIILKALKW 137
CYCLIN_CCNE_rpt1 cd20519
first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 106-236 5.13e-85

first cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form a serine/threonine kinase holoenzyme complexes. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410223  Cd Length: 131  Bit Score: 254.93  E-value: 5.13e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 106 SWACSQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKDVNKNML 185
Cdd:cd20519     1 SWADSEEVWDLMLKKEELYKRDRDFLNRHPSLQPRMRAILLDWLMEVCEVYRLHRETFYLAVDFVDRYLSTQTNVPKTQL 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1046888785 186 QLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKW 236
Cdd:cd20519    81 QLIGITCLFIAAKLEEIYPPKLSEFAYVTDGACTEDEILTMELIILKALNW 131
CYCLIN_CCNE1_rpt1 cd20579
first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 100-236 7.27e-74

first cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410282 [Multi-domain]  Cd Length: 137  Bit Score: 226.68  E-value: 7.27e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 100 SPLPDLSWACSQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKD 179
Cdd:cd20579     1 SPLPVLGWANRDEVWKNMLNKDKTYLRDKNFLQKHPLLQPKMRAILLDWLMEVCEVYKLHRETFYLAQDFFDRFMATQEN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1046888785 180 VNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKW 236
Cdd:cd20579    81 VVKTRLQLIGISSLFIAAKLEEIYPPKLHQFAYVTDGACTEDEILSMELIIMKALKW 137
CYCLIN_CCNE2_rpt2 cd20582
second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control ...
 240-328 5.13e-54

second cyclin box found in G1/S-specific cyclin-E2 (CCNE2); CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. CCNE2 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410285  Cd Length: 99  Bit Score: 174.19  E-value: 5.13e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 240 PVTVISWLNLFLQVDAVKDIPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWD 319
Cdd:cd20582     1 PVTIISWLNLYLQVDSLKDHPNVLLPQYSQETFIQIAQLLDLCILDINSLDFQYRVLAAAALCHFTSFEVVKKASGLEWD 80


                  ....*....
gi 1046888785 320 DISECVDWM 328
Cdd:cd20582    81 CISECVNWM 89
Cyclin_N pfam00134
Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 112-239 2.81e-51

Cyclin, N-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the N-terminal domain.


Pssm-ID: 459686 [Multi-domain]  Cd Length: 127  Bit Score: 168.08  E-value: 2.81e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 112 EVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGIT 191
Cdd:pfam00134   1 DIFQYLRELELKYLPKPDYMDQQPDINPKMRAILIDWLVEVHEKFKLLPETLYLAVNYLDRF-LSKKSVPKNKLQLVGVT 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1046888785 192 SLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWELC 239
Cdd:pfam00134  80 CLFIAAKYEEIYPPTVEDLVYITDNAYTREEILRMERLILETLNFDLS 127
CYCLIN_CCNB1-like_rpt1 cd20507
first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two ...
 110-235 5.30e-42

first cyclin box found in cyclin-B1 (CCNB1)-like family; The CCNB1-like family includes two B-type cyclins, CCNB1 and CCNB2, both of which are essential for the control of the cell cycle at the G2/M (mitosis) transition. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410211 [Multi-domain]  Cd Length: 130  Bit Score: 144.21  E-value: 5.30e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 110 SQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIG 189
Cdd:cd20507     5 VKDIYKYLRQLEKKYAIDPDYLSGQPEITERMRAILVDWLVEVHLKFKLLPETLYLTVNIIDRY-LSKKQVPRKKLQLVG 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1046888785 190 ITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALK 235
Cdd:cd20507    84 VTALLIASKYEEIYPPEIKDFVYITDNAYTREEILQMERDILKTLD 129
CYCLIN_CCNE1_rpt2 cd20581
second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control ...
 240-353 1.65e-40

second cyclin box found in G1/S-specific cyclin-E1 (CCNE1); CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE1 contains two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410284  Cd Length: 114  Bit Score: 139.53  E-value: 1.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 240 PVTVISWLNLFLQVDAVKDIPKVLLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILAAAALCHFTSIEVVKKASGLEWD 319
Cdd:cd20581     1 PLTIVSWLNVYMQVAYLNELQEVLLPQYPQEIFIQIAELLDLCVLDICCLEFPYGVLAASALYHFSSSELMQKVSGYKWC 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1046888785 320 DISECVDWMVPFVSVVKSVSPVKLKTFKKIPMED 353
Cdd:cd20581    81 EIEECVKWMVPFAMAIREVGSSKLKFFKGVAIED 114
CYCLIN_CCNA_rpt1 cd20504
first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, ...
 110-235 1.69e-38

first cyclin box found in cyclin-A (CCNA) family; The CCNA family includes two A-type cyclins, CCNA1 and CCNA2. CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. Members in this family contain two cyclin boxes. The model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410208 [Multi-domain]  Cd Length: 128  Bit Score: 134.68  E-value: 1.69e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 110 SQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIG 189
Cdd:cd20504     3 ADDIYEYLRESELKHRPKPDYMRKQPDINPSMRSILVDWLVEVAEEYKLVPETLYLAVNYIDRF-LSQMSVLRSKLQLVG 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1046888785 190 ITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALK 235
Cdd:cd20504    82 TACMFIAAKYEEIYPPEVEEFVYITDDTYTKKQVLRMEHLVLKVLS 127
CYCLIN_AtCycA_like_rpt1 cd20562
first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; ...
 106-237 2.86e-34

first cyclin box found in Arabidopsis thaliana A-type cyclins (CycAs) and similar proteins; Plant A-type cyclins (CycAs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycAs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410265  Cd Length: 136  Bit Score: 124.06  E-value: 2.86e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 106 SWACSQEVWQNMLQKESRYVHDkHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNML 185
Cdd:cd20562     7 LYATDIYLNLRVAELKRRPLPD-YMEKIQRDITPSMRGILVDWLVEVAEEYKLVPDTLYLTVSYIDRF-LSGNYVNRQRL 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1046888785 186 QLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWE 237
Cdd:cd20562    85 QLLGVSCMLIASKYEEICAPQVEEFCYITDNTYTKQEVLEMEIDVLNALQFE 136
CYCLIN_CCNE_rpt2 cd20520
second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two ...
 240-328 6.49e-34

second cyclin box found in G1/S-specific cyclin-E (CCNE) family; The CCNE family includes two E-type cyclins, CCNE1 and CCNE2. CCNE1 is essential for the control of the cell cycle at the G1/S (start) transition. It interacts with CDK2 protein kinase to form a serine/threonine kinase holoenzyme complex. CCNE2 is essential for the control of the cell cycle at the late G1 and early S phase. It interacts with the CDK2 (in vivo) and CDK3 (in vitro) protein kinases to form serine/threonine kinase holoenzyme complexes. Members in this family contain two cyclin boxes. This model corresponds to the second one. The cyclin box is a protein binding domain.


Pssm-ID: 410224 [Multi-domain]  Cd Length: 105  Bit Score: 122.01  E-value: 6.49e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 240 PVTVISWLNLFLQVDAVKDIPKV-----LLPQYSQETFIQIAQLLDLCILAIDSLEFQYRILAAAALCH-FTSIEVVKKA 313
Cdd:cd20520     1 PPTPNSWLNLYLQLAQLNPPPKEndsafLLPQYSLDRFVRAAQLLDLCILDIGSLQFSYSVLAASALYLvSPDDEAIEQV 80

                          90
                  ....*....|....*
gi 1046888785 314 SGLEWDDISECVDWM 328
Cdd:cd20520    81 TGYSWEQLAPCVEWM 95
CYCLIN_CLBs_yeast_rpt1 cd20568
first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces ...
 136-236 5.00e-33

first cyclin box found in yeast B-type cyclins; This subfamily includes Saccharomyces cerevisiae G2/mitotic-specific cyclins 1-4 (ScCLB1-4), S-phase entry cyclins 5-6 (ScCLB5-6), and Schizosaccharomyces pombe G2/mitotic-specific cyclins, cig1, cig2 and cdc13. ScCLB1-4 are essential for the control of the cell cycle at the G2/M (mitosis) transition. They interact with the CDC2 protein kinase to form maturation promoting factor (MPF). ScCLB5-6 interact with CDC28 and are involved in DNA replication in Saccharomyces cerevisiae. ScCLB5 is required for efficient progression through S phase and possibly for the normal progression through meiosis. ScCLB6 is involved in G1/S and or S phase progression. Cig1 is required for efficient passage of the G1/S transition. Cig2 and cdc13 are essential for the control of the cell cycle at the G2/M and G1/S (mitosis) transitions. They interact with the cdc2 protein kinase to form MPF. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410271  Cd Length: 134  Bit Score: 120.48  E-value: 5.00e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 136 DLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTD 215
Cdd:cd20568    35 ELRWKMRGILVDWLVEVHEKFRLLPETLFLAVNIIDRF-LSKRVVSLNKLQLVGISALFIASKYEEVNSPSIKNFAYMTD 113

                          90       100
                  ....*....|....*....|.
gi 1046888785 216 GACSEVDILKMELNILKALKW 236
Cdd:cd20568   114 GAYTVEDILRAERYMLNTLEF 134
CYCLIN_CCNB3_rpt1 cd20508
first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is ...
 111-235 8.10e-33

first cyclin box found in G2/mitotic-specific cyclin-B3 (CCNB3) and similar proteins; CCNB3 is a mitotic B-type cyclin that promotes the metaphase-anaphase transition. It controls anaphase onset independent of spindle assembly checkpoint in meiotic oocytes. CCNB3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410212 [Multi-domain]  Cd Length: 142  Bit Score: 120.44  E-value: 8.10e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 111 QEVWQNMLQKESRYVHDKHFEVlHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGI 190
Cdd:cd20508    18 KDIFDYMKEREEKFVVPDYLEK-QTELTPSMRAILVDWLVEVQENFELNHETLYLAVKLVDLY-LSKKVVKKEKLQLLGA 95

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1046888785 191 TSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALK 235
Cdd:cd20508    96 TAILIASKFDERCPPCVDDFLYICDDAYTREELLKMEREILKTLD 140
CYCLIN_CCNA1_rpt1 cd20560
first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of ...
 110-237 2.76e-27

first cyclin box found in cyclin-A1 (CCNA1); CCNA1 may primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. CCNA1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410263  Cd Length: 163  Bit Score: 106.08  E-value: 2.76e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 110 SQEVWQNMLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIG 189
Cdd:cd20560    37 AEDIHQYLREAELKHRPKPGYMRKQPDITTGMRTILVDWLVEVGEEYKLQTETLYLAVNYLDRF-LSCMSVLRGKLQLVG 115

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1046888785 190 ITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWE 237
Cdd:cd20560   116 TAAILLASKYEEIYPPEVDEFVYITDDTYTKKQLLRMEHLLLKVLAFD 163
CYCLIN_AtCycB-like_rpt1 cd20567
first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; ...
 136-236 3.38e-27

first cyclin box found in Arabidopsis thaliana B-type cyclins (CycBs) and similar proteins; Plant B-type cyclins (CycBs) correspond to a group of G2/mitotic-specific cyclins that are functionally linked to S- and M-phases of the mitotic cycle, which predicts their involvement also in meiosis. CycBs associate with their partner cyclin-dependent kinases (CDKs) to trigger the kinase activity. They contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410270  Cd Length: 147  Bit Score: 105.50  E-value: 3.38e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 136 DLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTD 215
Cdd:cd20567    48 DINEKMRAILIDWLIEVHLKFELMPETLYLTVNLIDRF-LSVKQVPRKELQLVGVTAMLIASKYEEIWAPEVNDFVYISD 126

                          90       100
                  ....*....|....*....|.
gi 1046888785 216 GACSEVDILKMELNILKALKW 236
Cdd:cd20567   127 NAYTRKQILVMEKTMLNTLEF 147
CYCLIN_CCNA2_rpt1 cd20561
first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S ...
 136-237 5.46e-27

first cyclin box found in cyclin-A2 (CCNA2) and similar proteins; CCNA2 controls both the G1/S and the G2/M transition phases of the cell cycle. It is significantly over-expressed in various cancer types, and can be used as a prognostic biomarker for estrogen receptor positive (ER+) breast cancer and tamoxifen resistance. CCNA2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410264 [Multi-domain]  Cd Length: 131  Bit Score: 104.37  E-value: 5.46e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 136 DLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTD 215
Cdd:cd20561    31 DITNSMRAILVDWLVEVGEEYKLQNETLHLAVNYIDRF-LSSMSVLRGKLQLVGTAAMLLASKFEEIYPPEVAEFVYITD 109

                          90       100
                  ....*....|....*....|..
gi 1046888785 216 GACSEVDILKMELNILKALKWE 237
Cdd:cd20561   110 DTYTKKQVLRMEHLVLKVLTFD 131
CYCLIN_CCND_rpt1 cd20515
first cyclin box found in cyclin-D (CCND) family; The CCND family includes three ...
 113-237 3.54e-26

first cyclin box found in cyclin-D (CCND) family; The CCND family includes three mitogen-induced D-type cyclins, CCND1, CCND2 and CCND3, which function as regulatory subunits of the cyclin-dependent kinases CDK4 and CDK6, that drive progression through the G1 phase of the cell cycle. Members in this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410219  Cd Length: 150  Bit Score: 102.76  E-value: 3.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 113 VWQNMLQKESRYVHDKH-FEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGIT 191
Cdd:cd20515    26 VLQNLLSLEERYLPSASyFKCVQTEIQPFMRKMVTTWMLEVCEEQNCEEEVFPLAVNYLDRF-LSLVPIRKSQLQLLGAV 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1046888785 192 SLFIASKLEE---IYAPKLqefAYVTDGACSEVDILKMELNILKALKWE 237
Cdd:cd20515   105 CLFLASKLKEtipLTAEKL---CIYTDNSITLQELLDWELLVLTKLKWD 150
COG5024 COG5024
Cyclin [Cell division and chromosome partitioning];
117-309 9.55e-26

Cyclin [Cell division and chromosome partitioning];


Pssm-ID: 227357 [Multi-domain]  Cd Length: 440  Bit Score: 107.94  E-value: 9.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 117 MLQKESRYVHDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGITSLFIA 196
Cdd:COG5024   188 LLKLELIDLPNPNYLIKQSLYEWSMRSILVDWLVEVHGKFGLLPETLFLAINIIDRF-LSSRVVSLEKYQLVGISALFIA 266

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 197 SKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWELCPVTVISWLNLFLQVDavkdipkvllpQYSQETFIQIA 276
Cdd:COG5024   267 SKYEEVNCPSIKDLVYATDGAFTRDDIIRAERYMLEVLDFNISWPSPMSFLRRISKAS-----------DYDIFSRTPAK 335

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1046888785 277 QLLDLCILAIDSLEFQYRILAAAAlcHFTSIEV 309
Cdd:COG5024   336 FSSEISPVDYKFIQISPSWCAAAA--MYLSRKI 366
CYCLIN_CCNB1_rpt1 cd20565
first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the ...
 141-236 3.24e-24

first cyclin box found in G2/mitotic-specific cyclin-B1 (CCNB1); CCNB1 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for embryo development. Over-expression of human CCNB1 has been found in numerous cancers and has been associated with tumor aggressiveness. CCNB1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410268 [Multi-domain]  Cd Length: 129  Bit Score: 96.87  E-value: 3.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 141 MRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSE 220
Cdd:cd20565    35 MRAILIDWLVQVQMKFRLLQETMYMTVAIIDRF-LQNNPVPKKMLQLVGVTAMFIASKYEEMYPPEIGDFAFVTDNTYTK 113

                          90
                  ....*....|....*.
gi 1046888785 221 VDILKMELNILKALKW 236
Cdd:cd20565   114 HQIRQMEMKILRALDF 129
CYCLIN_CCNB2_rpt1 cd20566
first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is ...
 124-236 1.45e-23

first cyclin box found in G2/mitotic-specific cyclin-B2 (CCNB2) and similar proteins; CCNB2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. It is required for progression through meiosis. CCNB2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410269 [Multi-domain]  Cd Length: 133  Bit Score: 95.31  E-value: 1.45e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 124 YVHDKHFEVLHS---------DLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKdVNKNMLQLIGITSLF 194
Cdd:cd20566    13 YQYLRQLEVQQSirphyldgkEINERMRAILVDWLVQVHSRFQLLQETLYMCVAIMDRFLQVQP-VSRKKLQLVGVTALL 91

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1046888785 195 IASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKW 236
Cdd:cd20566    92 LASKYEEMYSPEIGDFVYITDNAYTKAQIREMEMLILKELNF 133
CYCLIN_CCNO_rpt1 cd20536
first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required ...
 141-234 1.72e-23

first cyclin box found in cyclin-O (CCNO) and similar proteins; CCNO is specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. It acts downstream of MCIDAS (multiciliate differentiation and DNA synthesis associated cell cycle protein) to promote mother centriole amplification and maturation in preparation for apical docking. CCNO is involved in the activation of cyclin-dependent kinase 2. CCNO contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410239  Cd Length: 93  Bit Score: 93.55  E-value: 1.72e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 141 MRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKdVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSE 220
Cdd:cd20536     1 MRAKLISWLIPVHRHFNLSQETLFLAVNILDRFLATTP-VARDCFQLLGVTSLLIACKQEEIYPPEVKDLLALCCGAYTR 79

                          90
                  ....*....|....
gi 1046888785 221 VDILKMELNILKAL 234
Cdd:cd20536    80 EQICNLECIILTKL 93
CYCLIN_CNTD2 cd20542
cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; ...
 142-238 2.08e-22

cyclin box found in Cyclin N-terminal domain-containing protein 2 (CNTD2) and similar proteins; CNTD2 is an atypical cyclin upregulated in human cancer tissues. It promotes cell proliferation and migration, as well as increases tumor growth in vivo. It can function as a prognostic factor and drug target. CNTD2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410245 [Multi-domain]  Cd Length: 96  Bit Score: 90.84  E-value: 2.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 142 RSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKdVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEV 221
Cdd:cd20542     1 RAILVDWLVQVQEHLELSTQTLHLAVALLDRYLSRQK-ISLSLLQLLGITCLFIACKFEERFPPEVATLCYLTDDSYSKK 79

                          90
                  ....*....|....*..
gi 1046888785 222 DILKMELNILKALKWEL 238
Cdd:cd20542    80 QVLRMERRVLRRLRFDL 96
CYCLIN_CCND3_rpt1 cd20575
first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a ...
 99-237 2.36e-22

first cyclin box found in G1/S-specific cyclin-D3 (CCND3) and similar proteins; CCND3 is a regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. In skeletal muscle, CCND3 plays a unique function in controlling the proliferation/differentiation balance of myogenic progenitor cells. CCND3 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410278  Cd Length: 150  Bit Score: 92.36  E-value: 2.36e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785  99 PSPLPDLSWACSQEVWQNMLQKESRYV-HDKHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQ 177
Cdd:cd20575    12 PRAGPDPRLLGDQRVLQNLLRLEERYVpRVSYFQCVQREIKPYMRKMLAYWMLEVCEEQKCEEEVFPLAMNYVDRY-LSC 90

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 178 KDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWE 237
Cdd:cd20575    91 VPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDNSISPRQLLDWEILVLGKLKWD 150
CYCLIN_CCND2_rpt1 cd20574
first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of ...
 102-236 1.99e-21

first cyclin box found in G1/S-specific cyclin-D2 (CCND2); CCND2 is a regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1, and regulates the cell-cycle during G(1)/S transition. It is a critical mediator of exercise-induced cardiac hypertrophy. It also acts as a regulator of cell cycle proteins affecting SAMHD1-mediated HIV-1 restriction in non-proliferating macrophages. CCND2 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410277  Cd Length: 150  Bit Score: 89.67  E-value: 1.99e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 102 LPDLSWACSQEVWQNMLQKESRYVHD-KHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDV 180
Cdd:cd20574    15 LPDPNLLYDDRVLQNLLTIEERYLPQcSYFKCVQKDIQPFMRRMVATWMLEVCEEQKCEEEVFPLAMNYLDRF-LAVVPT 93

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1046888785 181 NKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKW 236
Cdd:cd20574    94 RKCHLQLLGAVCMFLASKLKETIPLTAEKLCIYTDNSIKPQELLEWELVVLGKLKW 149
CYCLIN_CCND1_rpt1 cd20573
first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma ...
 113-237 3.64e-20

first cyclin box found in G1/S-specific cyclin-D1 (CCND1); CCND1, also called B-cell lymphoma 1 protein (BCL-1), or BCL-1 oncogene, or PRAD1 oncogene, is a regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family, including RB1. The complex also regulates the cell-cycle during G(1)/S transition. It is an important cell cycle regulatory protein involved in carcinogenesis of various human cancers. CCND1 contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410276  Cd Length: 149  Bit Score: 86.19  E-value: 3.64e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 113 VWQNMLQKESRYVHD-KHFEVLHSDLEPQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGIT 191
Cdd:cd20573    25 VLQTMLKAEETCLPSvSYFKCVQKEILPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRF-LSVEPTKKSRLQLLGAT 103

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1046888785 192 SLFIASKLEEIYAPKLQEFAYVTDGACSEVDILKMELNILKALKWE 237
Cdd:cd20573   104 CMFLASKMKETIPLTAEKLCIYTDNSIRPEELLQMELLVLNKLKWD 149
CYCLIN smart00385
domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and ...
 147-232 6.70e-18

domain present in cyclins, TFIIB and Retinoblastoma; A helical domain present in cyclins and TFIIB (twice) and Retinoblastoma (once). A protein recognition domain functioning in cell-cycle and transcription control.


Pssm-ID: 214641 [Multi-domain]  Cd Length: 83  Bit Score: 77.63  E-value: 6.70e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785  147 DWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDgaCSEVDILKM 226
Cdd:smart00385   1 DFLRRVCKALNLDPETLNLAVNLLDRF-LSDYKFLKYSPSLIAAAALYLASKTEETPPWTKELVHYTGY--FTEEEILRM 77


                   ....*.
gi 1046888785  227 ELNILK 232
Cdd:smart00385  78 ERLLLE 83
CYCLIN_CCNJ-like_rpt1 cd20528
first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ ...
 140-236 2.00e-15

first cyclin box found in cyclin-J (CCNJ) family; The CCNJ family includes two cyclins, CCNJ and CCNJ-like. CCNJ may regulate the cell cycle or transcription. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410231 [Multi-domain]  Cd Length: 103  Bit Score: 71.48  E-value: 2.00e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 140 QMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLtQKDVNKNMLQLIGITSLFIASKLEEIYA--PKLQEF-AYVTDG 216
Cdd:cd20528     5 HLRRYLVDWLAVVSERLKLSDTTLHLAVYLLDRFMD-RYDISEDQLHLVALTCLLLAAKFEELDDniPKISDLnRYLCNS 83

                          90       100
                  ....*....|....*....|
gi 1046888785 217 ACSEVDILKMELNILKALKW 236
Cdd:cd20528    84 VYSKQEYLQMELLILEFFQW 103
CYCLIN_CCNF_rpt1 cd20521
first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also ...
 139-234 9.90e-14

first cyclin box found in G2/mitotic-specific cyclin-F (CCNF) and similar proteins; CCNF, also termed F-box only protein 1 (FBXO1), is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. CCNF contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410225  Cd Length: 95  Bit Score: 66.57  E-value: 9.90e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 139 PQMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTQKdVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGAC 218
Cdd:cd20521     1 DTMRYILVDWLVEVATMKDFSSLTLHVAVSCVDRYLMVRK-VPRSKLQLLGIACMVIATRFLGKDILTIREAAWLTDNTY 79

                          90
                  ....*....|....*.
gi 1046888785 219 SEVDILKMELNILKAL 234
Cdd:cd20521    80 KYEDVVRMMGEIVAAL 95
CYCLIN_AtCycD-like_rpt1 cd20543
first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta ...
 142-236 1.81e-13

first cyclin box found in plant cyclin-delta family; This subfamily is composed of plant delta family cyclins, including a group of G1/S-specific D-type cyclins from Arabidopsis thaliana which may activate the cell cycle in the root apical meristem (RAM) and promote embryonic root (radicle) protrusion. Members of this family contain two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410246  Cd Length: 99  Bit Score: 65.80  E-value: 1.81e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 142 RSILLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKN---MLQLIGITSLFIASKLEEIYAPKLQEFA-YVTDGA 217
Cdd:cd20543     2 RNEAIDWILKVRSRYGFGPLTAYLAVNYLDRF-LSSYDLPKDkpwMLQLLAVACLSLAAKMEETDVPLLVDLQvEEPKYV 80

                          90
                  ....*....|....*....
gi 1046888785 218 CSEVDILKMELNILKALKW 236
Cdd:cd20543    81 FEAKTIQRMELLVLSTLEW 99
CYCLIN_CCNI-like cd20526
cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because ...
 148-238 3.54e-13

cyclin box found in cyclin-I (CCNI) and similar proteins; CCNI is an atypical cyclin because it is most abundant in post-mitotic cells. It is involved in various biological processes, such as cell survival, angiogenesis, cell differentiation, and cell cycle progression. CCNI contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. The cyclin box is a protein binding domain.


Pssm-ID: 410230  Cd Length: 99  Bit Score: 65.03  E-value: 3.54e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 148 WLLEVCEVYTLHRETFYLAQDFFDRFMLTQKdVNKNMLQLIGITSLFIASKL--EEIYAPKLQEFAYVTDGACSEVDILK 225
Cdd:cd20526     8 WLAELNSQFKFYPETFALAVSILDRFLASVK-ARPKYLRCIAISCLFLAAKTneEDEVIPSTKDLVRVSKCGCSVAEVLR 86

                          90
                  ....*....|...
gi 1046888785 226 MELNILKALKWEL 238
Cdd:cd20526    87 MERIILDKLHWDL 99
CYCLIN_SF cd00043
Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in ...
 145-228 1.16e-12

Cyclin box fold superfamily; The cyclin box is a protein binding domain that functions in cell-cycle and transcriptional control. It is about 100 amino acids in length, composed of five helices, and is present in cyclins, transcription initiation factor IIB (TFIIB), and retinoblastoma tumour suppressor protein (Rb). Cyclins consist of 8 classes of cell cycle regulators that function as regulatory subunits of cyclin-dependent kinases (CDKs), which are serine/threonine kinases. The catalytic activities of CDKs are modulated not only by their interactions with cyclins but also by CDK inhibitors (CKIs). CDKs, cyclins and CKIs play key roles in transcription, epigenetic regulation, metabolism, stem cell self-renewal, neuronal functions, and spermatogenesis. TFIIB is a transcription factor that binds the TATA box. Members in this superfamily contain one or two copies of the cyclin box.


Pssm-ID: 410207 [Multi-domain]  Cd Length: 82  Bit Score: 63.20  E-value: 1.16e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 145 LLDWLLEVCEVYTLHRETFYLAQDFFDRFmLTQKDVNKNMLQLIGITSLFIASKLEEIYaPKLQEFAYVTDgaCSEVDIL 224
Cdd:cd00043     2 AVDFIRRLCSKLGLPEEVLELAIELLDRF-LSKGLLLGRSPELIAAACLYLACKLEELP-RTLKEIAKVSG--VSEKELR 77


                  ....
gi 1046888785 225 KMEL 228
Cdd:cd00043    78 KAEK 81
CYCLIN_vCyC_rpt1 cd20517
first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle ...
 140-236 2.88e-12

first cyclin box found in viral cyclin (v-cyclin); v-Cyclin modulates host cell cycle progression and apoptotic signaling pathways. It forms an active kinase complex with cellular CDK6, a cellular cyclin-dependent kinase known to interact with cellular type D cyclins. v-Cyclin belongs to Cyclin D subfamily. It contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410221  Cd Length: 99  Bit Score: 62.58  E-value: 2.88e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 140 QMRSILLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTqKDVNKNMLQLIGITSLFIASKLEEIYAPKLQEFAYVTDGACS 219
Cdd:cd20517     4 DNRKILLTWMFLVCESFELDKNVFPLAVSLLDRLLLK-KQGTKETLQKTGAACLLIASKIRTVKPITVSKLTYLSCDCFT 82

                          90
                  ....*....|....*..
gi 1046888785 220 EVDILKMELNILKALKW 236
Cdd:cd20517    83 NLELINQEKDILEALKW 99
CYCLIN_ScCLN_like cd20559
cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar ...
 145-236 2.01e-11

cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclins (ScCLNs) and similar proteins; ScCLNs, including ScCLN1-3, are essential for the control of the cell cycle at the G1/S (start) transition in Saccharomyces. ScCLN1 and ScCLN2 interact with the CDC28 protein kinase to form maturation promoting factor (MPF). ScCLN3 may be an upstream activator of the G1 cyclins that directly initiate G1/S transition. This family also includes Schizosaccharomyces pombe cyclin puc1, which contributes to negative regulation of the timing of sexual development in fission yeast, and functions at the transition between cycling and non-cycling cells. It interacts with protein kinase A. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410262 [Multi-domain]  Cd Length: 95  Bit Score: 60.09  E-value: 2.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 145 LLDWLLEVCEVYTLHRETFYLAQDFFDRFMLTqKDVNKNMLQLIGITSLFIASKLEEIYA--PKLQEFAYVTDGACSEVD 222
Cdd:cd20559     2 LLDFLFELHVELRLSPQTFFLSVNLIDRYCSK-RIVLKKHYQLVGCTCLWIASKFWESKArvPLLSELSKMCCNSYGEEL 80

                          90
                  ....*....|....
gi 1046888785 223 ILKMELNILKALKW 236
Cdd:cd20559    81 FIQMEMHILNTLNW 94
Cyclin_C pfam02984
Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a ...
 241-361 1.14e-10

Cyclin, C-terminal domain; Cyclins regulate cyclin dependent kinases (CDKs). Swiss:P22674 is a Uracil-DNA glycosylase that is related to other cyclins. Cyclins contain two domains of similar all-alpha fold, of which this family corresponds with the C-terminal domain.


Pssm-ID: 397230  Cd Length: 119  Bit Score: 58.40  E-value: 1.14e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 241 VTVISWLNLFLQVDAVKDIPKVL-LPQYsqetfiqiaqLLDLCILAIDSLEFQYRILAAAALCHFTSI-------EVVKK 312
Cdd:pfam02984   1 PTPLSFLRRFSKAADYLHDLELRtLAKY----------LLELTLLDYDFLKYPPSLIAAAAVYLARKTlnspewtETLEH 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1046888785 313 ASGLEWDDISECVDWMvpFVSVVKSVSPVKLKTFKKIPMEDRHNIQTHT 361
Cdd:pfam02984  71 YTGYSEEDLKPCVKLL--LELLLNAPSSKLQAVRRKYSSSKFMKVSTLP 117
CYCLIN_CCNH_rpt1 cd20524
first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called ...
 149-238 1.02e-06

first cyclin box found in cyclin-H (CCNH) and similar proteins; CCNH, also called MO15-associated protein, p34, or p37, is normally associated with the cyclin-dependent kinase cdk7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CCNH contains two cyclin boxes. This model corresponds to the first one. The cyclin box is a protein binding domain.


Pssm-ID: 410228  Cd Length: 150  Bit Score: 47.98  E-value: 1.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 149 LLEVCEVYTLHRETFYLAQDFFDRFMLTQ-------KDVnknMLqligiTSLFIASKLEEIYAPkLQEFAYVTDGACSEV 221
Cdd:cd20524    62 LLEFCRAFKLPDSVLATALTYFKRFYLKNsvmeyhpKEI---ML-----TCLYLACKVEEFNIS-IDQFVGNIKESEKTA 132

                          90
                  ....*....|....*...
gi 1046888785 222 D-ILKMELNILKALKWEL 238
Cdd:cd20524   133 EiILEYELLLLQGLNFHL 150
CYCLIN_CCNG cd20523
cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 ...
 149-234 1.11e-03

cyclin box found in the cyclin-G (CCNG) family; The CCNG family includes two cyclins, CCNG1 and CCNG2. CCNG1 is the only cyclin that has either positive or negative effects on cell growth. It is associated with G2/M phase arrest in response to DNA damage. It is also involved in the development of human carcinoma. CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. Members of this family contain one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410227  Cd Length: 94  Bit Score: 38.10  E-value: 1.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046888785 149 LLEVCEVYTLHRETFYLAQDFFDRFMLTQKdVNKNMLQLIGITSLFIASKL--EEIYAPKLQEFAYVTDGACSEVDILKM 226
Cdd:cd20523     8 LRCLHRFYGFSPETFALAVNLLDRFLSKVK-VKPKHLACITVSCFHIAIKSveEDQNIPSAEDLIRISQCGCTAADLMRM 86


                  ....*...
gi 1046888785 227 ELNILKAL 234
Cdd:cd20523    87 EGIILEKL 94
CYCLIN_CCNG2 cd20584
cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth ...
 161-227 9.25e-03

cyclin box found in cyclin-G2 (CCNG2) and similar proteins; CCNG2 may play a role in growth regulation and in negative regulation of cell cycle progression. It has been identified as a tumor suppressor in several cancers. CCNG2 contains one cyclin box. The cyclin box is a protein binding domain.


Pssm-ID: 410287  Cd Length: 96  Bit Score: 35.59  E-value: 9.25e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1046888785 161 ETFYLAQDFFDRFMLTQKdVNKNMLQLIGITSLFIASKL--EEIYAPKLQEFAYVTDGACSEVDILKME 227
Cdd:cd20584    21 ETFVLAVNILDRFLALMK-VKPKHLSCIGICCFHLAARVveEECNIPSSHDLIRISQCKCTVSDLKRME 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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