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Conserved domains on  [gi|1046848796|ref|XP_017452591|]
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sialate:O-sulfotransferase 1 isoform X1 [Rattus norvegicus]

Protein Classification

WSC domain-containing protein; sulfotransferase family protein( domain architecture ID 10646090)

WSC (cell wall integrity and stress response component) domain-containing protein may bind carbohydrates; the domain contains up to eight conserved cysteine residues that may be involved in disulfide bridges| sulfotransferase family protein may catalyze the transfer of sulfate from a donor such as 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to an acceptor substrate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 139-231 2.17e-30

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


:

Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 114.10  E-value: 2.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796  139 QGNYLGCFSEEgQERTLKGAVFYDLRKMTVSHCQEACAERSYVYAGLEAGAECYCGNRLPATRVSLK---ECNQECKGEK 215
Cdd:smart00321   1 GATYVGCYSDN-SSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALENGNECYCGDSLPSTSVSASdssQCSTTCSGYP 79

                           90
                   ....*....|....*.
gi 1046848796  216 GSMCGALHRLSVYSVG 231
Cdd:smart00321  80 AEVCGGPNRLSVYVLA 95
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 242-337 8.29e-22

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


:

Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 90.22  E-value: 8.29e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796  242 TATYRGCFPLPENITRTFSSSMTQANVTVETCSGFCSQKEFPLAILR-GWACYCAYPTPQFSLRdAVDGALCSQGTEAQG 320
Cdd:smart00321   1 GATYVGCYSDNSSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALEnGNECYCGDSLPSTSVS-ASDSSQCSTTCSGYP 79

                           90
                   ....*....|....*..
gi 1046848796  321 LPgYCEVYQTPVQDTRC 337
Cdd:smart00321  80 AE-VCGGPNRLSVYVLA 95
Sulfotransfer_1 super family cl21551
Sulfotransferase domain;
422-551 7.00e-08

Sulfotransferase domain;


The actual alignment was detected with superfamily member pfam00685:

Pssm-ID: 473908 [Multi-domain]  Cd Length: 253  Bit Score: 53.89  E-value: 7.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796 422 ILLIRNPYRSLVAEFNRKCAGHLGYAPDRnwKSKEWPDFVN---SYASWWSsHVLDWLKYGK--RLLVVHYEELRHSLVP 496
Cdd:pfam00685  96 IYLVRNPKDVAVSYYHFFRMAKLLKAPGT--PFEFVEDFLNgkvNCGSYFD-HVKGWWKLRPpgNILFLRYEDLKKDPRG 172

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046848796 497 TLREMVAFLNVSVSEERL-----LCVENN--------------KEGSFRRRGR----HPHdqepFTPEMKDLINGYIR 551
Cdd:pfam00685 173 EIKKIAEFLGIPLTEEELdkivkHLSFENmkgnpclnysklpkEVSPFFRKGLvgdwKNY----FTPEQAEKFDEIYQ 246
 
Name Accession Description Interval E-value
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 139-231 2.17e-30

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 114.10  E-value: 2.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796  139 QGNYLGCFSEEgQERTLKGAVFYDLRKMTVSHCQEACAERSYVYAGLEAGAECYCGNRLPATRVSLK---ECNQECKGEK 215
Cdd:smart00321   1 GATYVGCYSDN-SSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALENGNECYCGDSLPSTSVSASdssQCSTTCSGYP 79

                           90
                   ....*....|....*.
gi 1046848796  216 GSMCGALHRLSVYSVG 231
Cdd:smart00321  80 AEVCGGPNRLSVYVLA 95
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 142-221 3.55e-26

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 101.77  E-value: 3.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796 142 YLGCFSEEGQERTLKGAVFYDLRKMTVSHCQEACAERSYVYAGLEAGAECYCGNRLP--ATRVSLKECNQECKGEKGSMC 219
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGSSGDYDDMTPEKCIAFCSAAGYTYAGLEYGGECYCGNSLPsgSALADSSDCNTPCPGDSSQTC 80


                  ..
gi 1046848796 220 GA 221
Cdd:pfam01822  81 GG 82
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 242-337 8.29e-22

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 90.22  E-value: 8.29e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796  242 TATYRGCFPLPENITRTFSSSMTQANVTVETCSGFCSQKEFPLAILR-GWACYCAYPTPQFSLRdAVDGALCSQGTEAQG 320
Cdd:smart00321   1 GATYVGCYSDNSSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALEnGNECYCGDSLPSTSVS-ASDSSQCSTTCSGYP 79

                           90
                   ....*....|....*..
gi 1046848796  321 LPgYCEVYQTPVQDTRC 337
Cdd:smart00321  80 AE-VCGGPNRLSVYVLA 95
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 245-314 8.02e-13

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 64.02  E-value: 8.02e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046848796 245 YRGCFPL-PENITRTFSSSMTQANVTVETCSGFCSQKEFPLAILR-GWACYCAYPTPQFSLRDAVDgaLCSQ 314
Cdd:pfam01822   1 YLGCYSDgTGGRRLLLGSSGDYDDMTPEKCIAFCSAAGYTYAGLEyGGECYCGNSLPSGSALADSS--DCNT 70
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
422-551 7.00e-08

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 53.89  E-value: 7.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796 422 ILLIRNPYRSLVAEFNRKCAGHLGYAPDRnwKSKEWPDFVN---SYASWWSsHVLDWLKYGK--RLLVVHYEELRHSLVP 496
Cdd:pfam00685  96 IYLVRNPKDVAVSYYHFFRMAKLLKAPGT--PFEFVEDFLNgkvNCGSYFD-HVKGWWKLRPpgNILFLRYEDLKKDPRG 172

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046848796 497 TLREMVAFLNVSVSEERL-----LCVENN--------------KEGSFRRRGR----HPHdqepFTPEMKDLINGYIR 551
Cdd:pfam00685 173 EIKKIAEFLGIPLTEEELdkivkHLSFENmkgnpclnysklpkEVSPFFRKGLvgdwKNY----FTPEQAEKFDEIYQ 246
 
Name Accession Description Interval E-value
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 139-231 2.17e-30

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 114.10  E-value: 2.17e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796  139 QGNYLGCFSEEgQERTLKGAVFYDLRKMTVSHCQEACAERSYVYAGLEAGAECYCGNRLPATRVSLK---ECNQECKGEK 215
Cdd:smart00321   1 GATYVGCYSDN-SSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALENGNECYCGDSLPSTSVSASdssQCSTTCSGYP 79

                           90
                   ....*....|....*.
gi 1046848796  216 GSMCGALHRLSVYSVG 231
Cdd:smart00321  80 AEVCGGPNRLSVYVLA 95
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 142-221 3.55e-26

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 101.77  E-value: 3.55e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796 142 YLGCFSEEGQERTLKGAVFYDLRKMTVSHCQEACAERSYVYAGLEAGAECYCGNRLP--ATRVSLKECNQECKGEKGSMC 219
Cdd:pfam01822   1 YLGCYSDGTGGRRLLLGSSGDYDDMTPEKCIAFCSAAGYTYAGLEYGGECYCGNSLPsgSALADSSDCNTPCPGDSSQTC 80


                  ..
gi 1046848796 220 GA 221
Cdd:pfam01822  81 GG 82
WSC smart00321
present in yeast cell wall integrity and stress response component proteins; Domain present in ...
 242-337 8.29e-22

present in yeast cell wall integrity and stress response component proteins; Domain present in WSC proteins, polycystin and fungal exoglucanase


Pssm-ID: 214616 [Multi-domain]  Cd Length: 95  Bit Score: 90.22  E-value: 8.29e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796  242 TATYRGCFPLPENITRTFSSSMTQANVTVETCSGFCSQKEFPLAILR-GWACYCAYPTPQFSLRdAVDGALCSQGTEAQG 320
Cdd:smart00321   1 GATYVGCYSDNSSRTLAAVSSYAYHNMSVEACSNFCFSAGYALAALEnGNECYCGDSLPSTSVS-ASDSSQCSTTCSGYP 79

                           90
                   ....*....|....*..
gi 1046848796  321 LPgYCEVYQTPVQDTRC 337
Cdd:smart00321  80 AE-VCGGPNRLSVYVLA 95
WSC pfam01822
WSC domain; This domain is involved in carbohydrate binding.
 245-314 8.02e-13

WSC domain; This domain is involved in carbohydrate binding.


Pssm-ID: 460348  Cd Length: 82  Bit Score: 64.02  E-value: 8.02e-13
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1046848796 245 YRGCFPL-PENITRTFSSSMTQANVTVETCSGFCSQKEFPLAILR-GWACYCAYPTPQFSLRDAVDgaLCSQ 314
Cdd:pfam01822   1 YLGCYSDgTGGRRLLLGSSGDYDDMTPEKCIAFCSAAGYTYAGLEyGGECYCGNSLPSGSALADSS--DCNT 70
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
422-551 7.00e-08

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 53.89  E-value: 7.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1046848796 422 ILLIRNPYRSLVAEFNRKCAGHLGYAPDRnwKSKEWPDFVN---SYASWWSsHVLDWLKYGK--RLLVVHYEELRHSLVP 496
Cdd:pfam00685  96 IYLVRNPKDVAVSYYHFFRMAKLLKAPGT--PFEFVEDFLNgkvNCGSYFD-HVKGWWKLRPpgNILFLRYEDLKKDPRG 172

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1046848796 497 TLREMVAFLNVSVSEERL-----LCVENN--------------KEGSFRRRGR----HPHdqepFTPEMKDLINGYIR 551
Cdd:pfam00685 173 EIKKIAEFLGIPLTEEELdkivkHLSFENmkgnpclnysklpkEVSPFFRKGLvgdwKNY----FTPEQAEKFDEIYQ 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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