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Conserved domains on  [gi|1191825913|ref|XP_020924557|]
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nischarin isoform X3 [Sus scrofa]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-173 2.65e-24

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 2.65e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   39 IPTWQALTALDLSHNSISEIDESVKLIPKIEFLDLSHNGVLVV-DNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNIKTLN 117
Cdd:COG4886    155 LGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLD 234

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191825913  118 LAGNLLGSLHGLHKLYSLVNLDLSNNRIeqmEEVRSIGSLPCLEHVALLNNPLSII 173
Cdd:COG4886    235 LSNNQLTDLPELGNLTNLEELDLSNNQL---TDLPPLANLTNLKTLDLSNNQLTDL 287
BASP1 super family cl37731
Brain acid soluble protein 1 (BASP1 protein); This family consists of several brain acid ...
 773-877 2.88e-06

Brain acid soluble protein 1 (BASP1 protein); This family consists of several brain acid soluble protein 1 (BASP1) or neuronal axonal membrane protein NAP-22. The BASP1 is a neuron enriched Ca(2+)-dependent calmodulin-binding protein of unknown function.


The actual alignment was detected with superfamily member pfam05466:

Pssm-ID: 461658 [Multi-domain]  Cd Length: 238  Bit Score: 50.08  E-value: 2.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  773 AKTPATGG------RPQSPLADGQPTEGRARCSDDQHLQEALE----EVPVPAlAPAEAPGLAkipAPAEASEPALvlPE 842
Cdd:pfam05466  116 AAAPAASGeapkasEPSSEAKASQPSEAPATSKADDKSKEEGEakktEAPAAP-GAQETKSEA---APASDSKPSS--SE 189

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1191825913  843 ApteASASEETPAEASAGASVP------APAEGTAQAEAPA 877
Cdd:pfam05466  190 A---APSSKETPAATEAPSSTAkasepgAPAEEAKPSEAPA 227
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-173 2.65e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 2.65e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   39 IPTWQALTALDLSHNSISEIDESVKLIPKIEFLDLSHNGVLVV-DNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNIKTLN 117
Cdd:COG4886    155 LGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLD 234

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191825913  118 LAGNLLGSLHGLHKLYSLVNLDLSNNRIeqmEEVRSIGSLPCLEHVALLNNPLSII 173
Cdd:COG4886    235 LSNNQLTDLPELGNLTNLEELDLSNNQL---TDLPPLANLTNLKTLDLSNNQLTDL 287
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-182 5.47e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 98.70  E-value: 5.47e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   45 LTALDLSHNSISEIdESVKLIPKIEFLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLS----------SLEGVhtkLGNIK 114
Cdd:cd21340     48 LTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPpgekltfdprSLAAL---SNSLR 123

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191825913  115 TLNLAGNLLGSLHGLHKLYSLVNLDLSNNRIEQMEEV-RSIGSLPCLEHVALLNNPLSIIPDYRTKVLA 182
Cdd:cd21340    124 VLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKPKYRDKIIL 192
LRR_8 pfam13855
Leucine rich repeat;
89-145 1.09e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 1.09e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   89 NLVHLDLSYNKLSSLEGVH-TKLGNIKTLNLAGNLLGSLHG--LHKLYSLVNLDLSNNRI 145
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
BASP1 pfam05466
Brain acid soluble protein 1 (BASP1 protein); This family consists of several brain acid ...
 773-877 2.88e-06

Brain acid soluble protein 1 (BASP1 protein); This family consists of several brain acid soluble protein 1 (BASP1) or neuronal axonal membrane protein NAP-22. The BASP1 is a neuron enriched Ca(2+)-dependent calmodulin-binding protein of unknown function.


Pssm-ID: 461658 [Multi-domain]  Cd Length: 238  Bit Score: 50.08  E-value: 2.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  773 AKTPATGG------RPQSPLADGQPTEGRARCSDDQHLQEALE----EVPVPAlAPAEAPGLAkipAPAEASEPALvlPE 842
Cdd:pfam05466  116 AAAPAASGeapkasEPSSEAKASQPSEAPATSKADDKSKEEGEakktEAPAAP-GAQETKSEA---APASDSKPSS--SE 189

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1191825913  843 ApteASASEETPAEASAGASVP------APAEGTAQAEAPA 877
Cdd:pfam05466  190 A---APSSKETPAATEAPSSTAkasepgAPAEEAKPSEAPA 227
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 773-881 1.91e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.21  E-value: 1.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  773 AKTPATGGRPQSPLADGQPTEGRARCSDDQHLQEALEEVPVPALAPAEAPG---LAKIPAPAEASEPALVLPEAPTEASA 849
Cdd:PRK07764   394 PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPagnAPAGGAPSPPPAAAPSAQPAPAPAAA 473

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1191825913  850 SEETPAEASAGASVPAPAEGTAQAEAPAQYPS 881
Cdd:PRK07764   474 PEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAG 505
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-158 1.08e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   45 LTALDLSHNSISE-IDESVKLIPKIEFLDLSHNGV--LVVDNLQHLYNLVHLDLSYNKLS-SLEGVHTKLGNIKTLNLAG 120
Cdd:PLN00113   477 LENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLsgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1191825913  121 NLL-GSL-HGLHKLYSLVNLDLSNNRIEqmeevrsiGSLP 158
Cdd:PLN00113   557 NQLsGEIpKNLGNVESLVQVNISHNHLH--------GSLP 588
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 817-876 1.84e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 42.19  E-value: 1.84e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  817 APAEAPGLAKIPAPAEASEPALVLPEAPTeASASEETPAEASAGASVPAPAEGTAQAEAP 876
Cdd:TIGR00601   86 PPAATPTSAPTPTPSPPASPASGMSAAPA-SAVEEKSPSEESATATAPESPSTSVPSSGS 144
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-173 2.65e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 2.65e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   39 IPTWQALTALDLSHNSISEIDESVKLIPKIEFLDLSHNGVLVV-DNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNIKTLN 117
Cdd:COG4886    155 LGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLD 234

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1191825913  118 LAGNLLGSLHGLHKLYSLVNLDLSNNRIeqmEEVRSIGSLPCLEHVALLNNPLSII 173
Cdd:COG4886    235 LSNNQLTDLPELGNLTNLEELDLSNNQL---TDLPPLANLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-175 3.82e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 106.94  E-value: 3.82e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   39 IPTWQALTALDLSHNSISEIDESVKLIPKIEFLDLSHNGVLVVDN-LQHLYNLVHLDLSYNKLSSLEGVHTKLGNIKTLN 117
Cdd:COG4886    132 LANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEeLGNLTNLKELDLSNNQITDLPEPLGNLTNLEELD 211

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1191825913  118 LAGNLLGSL-HGLHKLYSLVNLDLSNNRIEQMEEvrsIGSLPCLEHVALLNNPLSIIPD 175
Cdd:COG4886    212 LSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPE---LGNLTNLEELDLSNNQLTDLPP 267
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 45-182 5.47e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 98.70  E-value: 5.47e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   45 LTALDLSHNSISEIdESVKLIPKIEFLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLS----------SLEGVhtkLGNIK 114
Cdd:cd21340     48 LTHLYLQNNQIEKI-ENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPpgekltfdprSLAAL---SNSLR 123

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191825913  115 TLNLAGNLLGSLHGLHKLYSLVNLDLSNNRIEQMEEV-RSIGSLPCLEHVALLNNPLSIIPDYRTKVLA 182
Cdd:cd21340    124 VLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELlDLLSSWPSLRELDLTGNPVCKKPKYRDKIIL 192
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-175 1.96e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.47  E-value: 1.96e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   39 IPTWQALTALDLSHNSISEIDESVKLIPKIEFLDLSHNGV-LVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNIKTLN 117
Cdd:COG4886    109 LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLtDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELD 188

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1191825913  118 LAGNLLGSL-HGLHKLYSLVNLDLSNNRIEQMEEvrSIGSLPCLEHVALLNNPLSIIPD 175
Cdd:COG4886    189 LSNNQITDLpEPLGNLTNLEELDLSGNQLTDLPE--PLANLTNLETLDLSNNQLTDLPE 245
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
43-149 7.69e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 87.68  E-value: 7.69e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   43 QALTALDLSHNSISEIDESVKLIPKIEFLDLSHNGVLVV-DNLQHLYNLVHLDLSYNKLSSLEGVhTKLGNIKTLNLAGN 121
Cdd:COG4886    182 TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPEL-GNLTNLEELDLSNN 260

                           90       100
                   ....*....|....*....|....*...
gi 1191825913  122 LLGSLHGLHKLYSLVNLDLSNNRIEQME 149
Cdd:COG4886    261 QLTDLPPLANLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-175 1.55e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.36  E-value: 1.55e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   45 LTALDLSHNSISEIDESVKLIPKIEFLDLSHNgvlvvDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNIKTLNLAGNLLG 124
Cdd:COG4886     75 LLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLT 149

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1191825913  125 SLH-GLHKLYSLVNLDLSNNRIEQMEEvrSIGSLPCLEHVALLNNPLSIIPD 175
Cdd:COG4886    150 DLPePLGNLTNLKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDLPE 199
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-142 1.13e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 1.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   39 IPTWQALTALDLSHNSISEIDESVKLiPKIEFLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLSSLEgvHTKLGNIKTLNL 118
Cdd:COG4886    224 LANLTNLETLDLSNNQLTDLPELGNL-TNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK--LKELELLLGLNS 300

                           90       100
                   ....*....|....*....|....
gi 1191825913  119 AGNLLGSLHGLHKLYSLVNLDLSN 142
Cdd:COG4886    301 LLLLLLLLNLLELLILLLLLTTLL 324
LRR_8 pfam13855
Leucine rich repeat;
89-145 1.09e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.83  E-value: 1.09e-07
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   89 NLVHLDLSYNKLSSLEGVH-TKLGNIKTLNLAGNLLGSLHG--LHKLYSLVNLDLSNNRI 145
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 44-171 1.99e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 54.28  E-value: 1.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   44 ALTALDLSHNSISE----IDESVKLIPKIEFLDLSHNGV------LVVDNLQHLY-NLVHLDLSYNKLSS-----LEGVH 107
Cdd:cd00116     82 GLQELDLSDNALGPdgcgVLESLLRSSSLQELKLNNNGLgdrglrLLAKGLKDLPpALEKLVLGRNRLEGasceaLAKAL 161

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1191825913  108 TKLGNIKTLNLAGNLLGS------LHGLHKLYSLVNLDLSNNRIE-----QMEEVrsIGSLPCLEHVALLNNPLS 171
Cdd:cd00116    162 RANRDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLTdegasALAET--LASLKSLEVLNLGDNNLT 234
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 44-147 2.79e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.90  E-value: 2.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   44 ALTALDLSHNSIS-----EIDESVKLIPKIEFLDLSHNGVLV------VDNLQHLYNLVHLDLSYNKL-----SSLEGVH 107
Cdd:cd00116    138 ALEKLVLGRNRLEgasceALAKALRANRDLKELNLANNGIGDagiralAEGLKANCNLEVLDLNNNGLtdegaSALAETL 217

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1191825913  108 TKLGNIKTLNLAGNLLGSLhGLHKL--------YSLVNLDLSNNRIEQ 147
Cdd:cd00116    218 ASLKSLEVLNLGDNNLTDA-GAAALasallspnISLLTLSLSCNDITD 264
BASP1 pfam05466
Brain acid soluble protein 1 (BASP1 protein); This family consists of several brain acid ...
 773-877 2.88e-06

Brain acid soluble protein 1 (BASP1 protein); This family consists of several brain acid soluble protein 1 (BASP1) or neuronal axonal membrane protein NAP-22. The BASP1 is a neuron enriched Ca(2+)-dependent calmodulin-binding protein of unknown function.


Pssm-ID: 461658 [Multi-domain]  Cd Length: 238  Bit Score: 50.08  E-value: 2.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  773 AKTPATGG------RPQSPLADGQPTEGRARCSDDQHLQEALE----EVPVPAlAPAEAPGLAkipAPAEASEPALvlPE 842
Cdd:pfam05466  116 AAAPAASGeapkasEPSSEAKASQPSEAPATSKADDKSKEEGEakktEAPAAP-GAQETKSEA---APASDSKPSS--SE 189

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1191825913  843 ApteASASEETPAEASAGASVP------APAEGTAQAEAPA 877
Cdd:pfam05466  190 A---APSSKETPAATEAPSSTAkasepgAPAEEAKPSEAPA 227
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 45-145 5.16e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 50.56  E-value: 5.16e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   45 LTALDLSHNSISE-----IDESVKLIPKIEFLDLSHN-----GVLV-VDNLQHLYNLVHLDLSYNKLSSLEGV----HTK 109
Cdd:COG5238    266 VETLYLSGNQIGAegaiaLAKALQGNTTLTSLDLSVNrigdeGAIAlAEGLQGNKTLHTLNLAYNGIGAQGAIalakALQ 345

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1191825913  110 LG-NIKTLNLAGNLLG--SLHGLHKLY----SLVNLDLSNNRI 145
Cdd:COG5238    346 ENtTLHSLDLSDNQIGdeGAIALAKYLegntTLRELNLGKNNI 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-175 1.48e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 1.48e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   30 ALEGPVTAIIPTWQALTALDLSHNSISEIDESVKLIPKIEFLDLSHNGVLVVDNLQHLYNLVHLDLSYNKLSSLEGVhTK 109
Cdd:COG4886     16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL-GD 94

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1191825913  110 LGNIKTLNLAGNLlgslhGLHKLYSLVNLDLSNNRIEQMEEvrSIGSLPCLEHVALLNNPLSIIPD 175
Cdd:COG4886     95 LTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLPE--ELANLTNLKELDLSNNQLTDLPE 153
Rib_recp_KP_reg pfam05104
Ribosome receptor lysine/proline rich region; This highly conserved region is found towards ...
 806-877 1.84e-05

Ribosome receptor lysine/proline rich region; This highly conserved region is found towards the C-terminus of the transmembrane domain. The function is unclear.


Pssm-ID: 461548 [Multi-domain]  Cd Length: 140  Bit Score: 45.88  E-value: 1.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  806 EALEEVPVPALAPAEAPGLAKIPAPAE--ASEPALVLPEAPTEASAS---EE-------TPAEASAGASVPAPAEGTAQA 873
Cdd:pfam05104   57 DESEEEPREFKTPDEAPSAALEPEPVPtpVPAPVEPEPAPPSESPAPspkEKkkkekksAKVEPAETPEAVQPKPALEKE 136


                   ....
gi 1191825913  874 EAPA 877
Cdd:pfam05104  137 EPPA 140
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 773-881 1.91e-05

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 49.21  E-value: 1.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  773 AKTPATGGRPQSPLADGQPTEGRARCSDDQHLQEALEEVPVPALAPAEAPG---LAKIPAPAEASEPALVLPEAPTEASA 849
Cdd:PRK07764   394 PAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAPPSPagnAPAGGAPSPPPAAAPSAQPAPAPAAA 473

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1191825913  850 SEETPAEASAGASVPAPAEGTAQAEAPAQYPS 881
Cdd:PRK07764   474 PEPTAAPAPAPPAAPAPAAAPAAPAAPAAPAG 505
LRR_9 pfam14580
Leucine-rich repeat;
71-184 2.84e-05

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 45.91  E-value: 2.84e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   71 LDLSHNGVLVVDNL-QHLYNLVHLDLSYNKLSSLEGVhTKLGNIKTLNLAGN-LLGSLHGLHK-LYSLVNLDLSNNRIEQ 147
Cdd:pfam14580   24 LDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGF-PLLRRLKTLLLNNNrICRIGEGLGEaLPNLTELILTNNNLQE 102

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1191825913  148 MEEVRSIGSLPCLEHVALLNNPLSIIPDYRTKVLAQF 184
Cdd:pfam14580  103 LGDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKV 139
DUF4813 pfam16072
Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. ...
 812-882 5.64e-05

Domain of unknown function (DUF4813); This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 345 and 672 amino acids in length.


Pssm-ID: 435117 [Multi-domain]  Cd Length: 288  Bit Score: 46.67  E-value: 5.64e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191825913  812 PVPALAPAEAPGLAKIPAPAEASEPalVLPEAPTEASASEETPAEASAGASVPAPAEGTAQAEAPAQYPSE 882
Cdd:pfam16072  178 VAPAAYPAQAPAAAPAPAPGAPQTP--LAPLNPVAAAPAAAAGAAAAPVVAAAAPAAAAPPPPAPAAPPAD 246
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 814-903 5.75e-05

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 47.40  E-value: 5.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  814 PALAPAEAPGLAKIPAPAEASEPALVLPEAPTEASASEETPAEASAGASVPAPAEGTAQAEAPAQYPSERLIQSMSEENQ 893
Cdd:PRK14951   367 AAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAAAPAAVA 446

                           90
                   ....*....|
gi 1191825913  894 IPSHLPACPS 903
Cdd:PRK14951   447 LAPAPPAQAA 456
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
772-877 6.70e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.54  E-value: 6.70e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  772 IAKTPATGGrPQSPLADGQPTEGRARCSDDQHLQEALEEVPVPALAPAEAPGLAKiPAPAEASEPALVLPEAPTEASASE 851
Cdd:PRK07003   356 LAFEPAVTG-GGAPGGGVPARVAGAVPAPGARAAAAVGASAVPAVTAVTGAAGAA-LAPKAAAAAAATRAEAPPAAPAPP 433

                           90       100
                   ....*....|....*....|....*.
gi 1191825913  852 ETPAEASAGASVPAPAEGTAQAEAPA 877
Cdd:PRK07003   434 ATADRGDDAADGDAPVPAKANARASA 459
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
773-887 7.71e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 47.18  E-value: 7.71e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  773 AKTPATGGRPQSPLADGQPTE-GRARCSDDQHLQEALEEVPVPALAPAEAPGLAKIPAPAEASEPAlvlPEAPTEASASE 851
Cdd:PRK12323   394 AAAPAPAAPPAAPAAAPAAAAaARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAPAPAAAPA---AAARPAAAGPR 470

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1191825913  852 ETPAEASAGASVPAPAEGTAQA--------EAPAQYPSERLIQS 887
Cdd:PRK12323   471 PVAAAAAAAPARAAPAAAPAPAdddpppweELPPEFASPAPAQP 514
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
776-877 8.43e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.15  E-value: 8.43e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  776 PATGGRPQSPLADGQPTEGRA--RCSDDQHLQEALEEvPVPALAPAEAP-GLAKIPAPAEASEPALVLPEAPTEASASEE 852
Cdd:PRK07003   433 PATADRGDDAADGDAPVPAKAnaRASADSRCDERDAQ-PPADSGSASAPaSDAPPDAAFEPAPRAAAPSAATPAAVPDAR 511

                           90       100
                   ....*....|....*....|....*
gi 1191825913  853 TPAEASAGASVPAPAEGTAQAEAPA 877
Cdd:PRK07003   512 APAAASREDAPAAAAPPAPEARPPT 536
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 66-105 9.36e-05

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 41.08  E-value: 9.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1191825913   66 PKIEFLDLSHNGVLVVDNLQHLYNLVHLDLSYN-KLSSLEG 105
Cdd:pfam12799    1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSD 41
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 774-905 1.08e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.52  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  774 KTPATGGRPQSPLADGQPTEGRARCSDDQ------HLQEALEEVPVPALAPAEAPGLAKIPAPAEASEPAlvlPEAPTEA 847
Cdd:PRK07764   616 AAPAAPAAPAAPAPAGAAAAPAEASAAPApgvaapEHHPKHVAVPDASDGGDGWPAKAGGAAPAAPPPAP---APAAPAA 692

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1191825913  848 SASEETPAEASAGASVPAPAEGTAQAEAPAQYPSERLIQSMSEENQIPshLPACPSLQ 905
Cdd:PRK07764   693 PAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP--LPPEPDDP 748
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-158 1.08e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.76  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   45 LTALDLSHNSISE-IDESVKLIPKIEFLDLSHNGV--LVVDNLQHLYNLVHLDLSYNKLS-SLEGVHTKLGNIKTLNLAG 120
Cdd:PLN00113   477 LENLDLSRNQFSGaVPRKLGSLSELMQLKLSENKLsgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1191825913  121 NLL-GSL-HGLHKLYSLVNLDLSNNRIEqmeevrsiGSLP 158
Cdd:PLN00113   557 NQLsGEIpKNLGNVESLVQVNISHNHLH--------GSLP 588
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 112-153 1.16e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 40.69  E-value: 1.16e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1191825913  112 NIKTLNLAGNLLGSLHGLHKLYSLVNLDLS-NNRIEQMEEVRS 153
Cdd:pfam12799    2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
PRK14965 PRK14965
DNA polymerase III subunits gamma and tau; Provisional
 806-882 1.23e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237871 [Multi-domain]  Cd Length: 576  Bit Score: 46.27  E-value: 1.23e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1191825913  806 EALEE-VPVPALAPAEAPGLAKIPAPAEASEPAlvlPEAPTEASASEETPAEASAGASVPAPAEGTAQAEAPAQYPSE 882
Cdd:PRK14965   375 EALERgAPAPPSAAWGAPTPAAPAAPPPAAAPP---VPPAAPARPAAARPAPAPAPPAAAAPPARSADPAAAASAGDR 449
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 773-882 1.25e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 46.52  E-value: 1.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  773 AKTPATGGRPQSPLADGQPTEGRArcsddqHLQEALEEVPVPALAPAEAPGlakiPAPAEASEPALVLPEAPTEASASEE 852
Cdd:PRK07764   390 GAGAPAAAAPSAAAAAPAAAPAPA------AAAPAAAAAPAPAAAPQPAPA----PAPAPAPPSPAGNAPAGGAPSPPPA 459

                           90       100       110
                   ....*....|....*....|....*....|
gi 1191825913  853 TPAEASAGASVPAPAEGTAQAEAPAQYPSE 882
Cdd:PRK07764   460 AAPSAQPAPAPAAAPEPTAAPAPAPPAAPA 489
LRR_8 pfam13855
Leucine rich repeat;
112-170 1.43e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.97  E-value: 1.43e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1191825913  112 NIKTLNLAGNLLGSLHG--LHKLYSLVNLDLSNNRIEQMEEvRSIGSLPCLEHVALLNNPL 170
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 812-895 1.44e-04

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 46.42  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  812 PVPALAPAEAPGLAKIPAPAEASEPALVLPEAPTEASASEETPAEASAGASVPAPAEGTAQAEAPAQYPSE--------- 882
Cdd:PRK12270    44 PTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEdevtplrga 123

                           90
                   ....*....|....*
gi 1191825913  883 --RLIQSMSEENQIP 895
Cdd:PRK12270   124 aaAVAKNMDASLEVP 138
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 811-900 1.85e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.86  E-value: 1.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  811 VPVPALAPAEAPGLAKIPAPAEASEPALVLPEAPTEASASEETPAEASAGASVPAPAEGTAQAEAPAQYPSerlIQSMSE 890
Cdd:PRK14951   370 AEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAAAPPAPVAAPAAAAPAAAPAA---APAAVA 446

                           90
                   ....*....|
gi 1191825913  891 ENQIPSHLPA 900
Cdd:PRK14951   447 LAPAPPAQAA 456
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 44-163 1.87e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.55  E-value: 1.87e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   44 ALTALDLSHNSISeiDESVKLIPK-------IEFLDLSHNGV------LVVDNLQHLYNLVHLDLSYNKLS--SLEGVHT 108
Cdd:COG5238    293 TLTSLDLSVNRIG--DEGAIALAEglqgnktLHTLNLAYNGIgaqgaiALAKALQENTTLHSLDLSDNQIGdeGAIALAK 370

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1191825913  109 KL---GNIKTLNLAGNLLG-----SLHGLHKLYSLVNLDLSNNRIEQMEEVRSIGSLPCLEHV 163
Cdd:COG5238    371 YLegnTTLRELNLGKNNIGkqgaeALIDALQTNRLHTLILDGNLIGAEAQQRLEQLLERIKSV 433
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 45-89 2.02e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.02e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1191825913   45 LTALDLSHNSISEIDESVKLiPKIEFLDLSHNGVLvvDNLQHLYN 89
Cdd:pfam12799    3 LEVLDLSNNQITDIPPLAKL-PNLETLDLSGNNKI--TDLSDLAN 44
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 776-909 2.37e-04

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 45.48  E-value: 2.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  776 PATGGRPQSPLADGQPTEgrarcsddqhlqEALEEVPVPALAPAEAPglakiPAPAEASEPALVLPEAPTEASASEETPA 855
Cdd:PRK14951   371 EAAAPAEKKTPARPEAAA------------PAAAPVAQAAAAPAPAA-----APAAAASAPAAPPAAAPPAPVAAPAAAA 433

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1191825913  856 EASAGASVPAPAEgtAQAEAPAQYPSERLIQSMSEENQIPSHLPACPSLQHIAS 909
Cdd:PRK14951   434 PAAAPAAAPAAVA--LAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAA 485
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 774-903 4.78e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.78  E-value: 4.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  774 KTPATGGRPQSPLADGQ-PTEGRARCSDDqhlqEALEEVPVPALAPAEAPGLAKIPAPAEASEPALVLPEAPTEASASEE 852
Cdd:PHA03307    95 LAPASPAREGSPTPPGPsSPDPPPPTPPP----ASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSR 170

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1191825913  853 TPAEASAGASVPAPAEGTAQAEAPAQYPSERLIQSMSEENQIPSHLPACPS 903
Cdd:PHA03307   171 QAALPLSSPEETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPA 221
PHA03247 PHA03247
large tegument protein UL36; Provisional
 775-904 5.32e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 5.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  775 TPATGGRPQSPLADGQPTEGRARcsddqhlqealeevPVPALAPAEAPGLAKIPAPAEASEPALVLPEAPTEASA-SEET 853
Cdd:PHA03247  2738 APAPPAVPAGPATPGGPARPARP--------------PTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLpSPWD 2803

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1191825913  854 PAEASAGASVPAPAEGTAQAEAPAQYPSerliqsmseenqiPSHLPACPSL 904
Cdd:PHA03247  2804 PADPPAAVLAPAAALPPAASPAGPLPPP-------------TSAQPTAPPP 2841
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-207 5.68e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.77  E-value: 5.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   45 LTALDLSHNSISEIDESVKLiPKIEFLDLSHNGvLVVDNLQHLYNLVHLDLSYNKLSSLEGVHTKLGNIKTLNLAGNLLG 124
Cdd:COG4886    252 LEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQ-LTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  125 SLHGLHKLYSLVNLDLSNNRIEQMEEVRSIGSLPCLEHVALLNNPLSIIPDYRTKVLAQFGERASEVCLDNTVTTEKELD 204
Cdd:COG4886    330 LKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409


                   ...
gi 1191825913  205 TVE 207
Cdd:COG4886    410 AVN 412
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
773-877 6.51e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 44.07  E-value: 6.51e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  773 AKTPATGGRPQSPLADGQPT---EGRARCSDDQHLQEALEEVPVPALAPAEAPGLAKIPAPAEASEPAlvlPEAPTEASA 849
Cdd:PRK07003   414 AAAAAAATRAEAPPAAPAPPataDRGDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASAPA---SDAPPDAAF 490

                           90       100
                   ....*....|....*....|....*...
gi 1191825913  850 SEETPAEASAGASVPAPAEGTAQAEAPA 877
Cdd:PRK07003   491 EPAPRAAAPSAATPAAVPDARAPAAASR 518
PHA03247 PHA03247
large tegument protein UL36; Provisional
 771-876 6.74e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 6.74e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  771 VIAKTPATGGRPQSPLADGQPTEGRARCSDDQhlqealEEVPVPALAPAeAPGLAKIPAPAEASE-PALVLPEAPTEASA 849
Cdd:PHA03247  2749 ATPGGPARPARPPTTAGPPAPAPPAAPAAGPP------RRLTRPAVASL-SESRESLPSPWDPADpPAAVLAPAAALPPA 2821

                           90       100
                   ....*....|....*....|....*..
gi 1191825913  850 SEETPAEASAGASVPAPAEGTAQAEAP 876
Cdd:PHA03247  2822 ASPAGPLPPPTSAQPTAPPPPPGPPPP 2848
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
772-880 1.02e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 43.33  E-value: 1.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  772 IAKTPATGGRPQSPLADGQPTEGRARCSDDQHLQEALEEVPVPALAPAEAPGLAKIPAPAEAS---EPALVLPEAPTEAS 848
Cdd:PRK12323   361 LAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAParrSPAPEALAAARQAS 440

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1191825913  849 ASEETPAEASAGASVPAPAEGTAQAEAPAQYP 880
Cdd:PRK12323   441 ARGPGGAPAPAPAPAAAPAAAARPAAAGPRPV 472
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
775-899 1.83e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 42.56  E-value: 1.83e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  775 TPATGGRPQSPLADGQPTEGRARCSDDQHLQEALEEVPVPALAPAEAPGLakiPAPAEASEPALVLPEAPTEASASEETP 854
Cdd:PRK12323   376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPAR---RSPAPEALAAARQASARGPGGAPAPAP 452

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1191825913  855 AEASAGASVPAPAEGTAQAEAPAQYPSERLIQSMSEENQIPSHLP 899
Cdd:PRK12323   453 APAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPP 497
rad23 TIGR00601
UV excision repair protein Rad23; All proteins in this family for which functions are known ...
 817-876 1.84e-03

UV excision repair protein Rad23; All proteins in this family for which functions are known are components of a multiprotein complex used for targeting nucleotide excision repair to specific parts of the genome. In humans, Rad23 complexes with the XPC protein. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273167 [Multi-domain]  Cd Length: 378  Bit Score: 42.19  E-value: 1.84e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  817 APAEAPGLAKIPAPAEASEPALVLPEAPTeASASEETPAEASAGASVPAPAEGTAQAEAP 876
Cdd:TIGR00601   86 PPAATPTSAPTPTPSPPASPASGMSAAPA-SAVEEKSPSEESATATAPESPSTSVPSSGS 144
rne PRK10811
ribonuclease E; Reviewed
 782-878 2.47e-03

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 42.33  E-value: 2.47e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  782 PQSPLADGQPTEGRARcsDDQHLQEALEEVPVPALAPAEAPGLAKIPAPAEASEPALVLPEAPTEASASEETPAEASAgA 861
Cdd:PRK10811   846 PVVRPQDVQVEEQREA--EEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQPEEVVVVETTHPEVIA-A 922

                           90
                   ....*....|....*..
gi 1191825913  862 SVPAPAEGTAQAEAPAQ 878
Cdd:PRK10811   923 PVTEQPQVITESDVAVA 939
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 31-171 3.52e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 3.52e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   31 LEGPVTAIIPTWQALTALDLSHNSIS-EIDESVKLIPKIEFLDLSHNGVL--VVDNLQHLYNLVHLDLSYNKLSSleGVH 107
Cdd:PLN00113   272 LSGPIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgkIPVALTSLPRLQVLQLWSNKFSG--EIP 349

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191825913  108 TKLG---NIKTLNLAGN-LLGSL-HGLHKLYSLVNLDLSNNRIEQmEEVRSIGSLPCLEHVALLNNPLS 171
Cdd:PLN00113   350 KNLGkhnNLTVLDLSTNnLTGEIpEGLCSSGNLFKLILFSNSLEG-EIPKSLGACRSLRRVRLQDNSFS 417
PLN03150 PLN03150
hypothetical protein; Provisional
 31-101 3.88e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 41.34  E-value: 3.88e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1191825913   31 LEGPVTAIIPTWQALTALDLSHNSI-SEIDESVKLIPKIEFLDLSHNGV--LVVDNLQHLYNLVHLDLSYNKLS 101
Cdd:PLN03150   430 LRGFIPNDISKLRHLQSINLSGNSIrGNIPPSLGSITSLEVLDLSYNSFngSIPESLGQLTSLRILNLNGNSLS 503
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 781-884 4.91e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 41.00  E-value: 4.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913  781 RPQSPLAdgQPTEGRARCSDDQHLQEAleEVPVPALAPAEAPGLAKIPAPAEASEPALVLPEAPTEASASEETPAEASAG 860
Cdd:PRK07994   360 HPAAPLP--EPEVPPQSAAPAASAQAT--AAPTAAVAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAARQQLQRAQGA 435

                           90       100
                   ....*....|....*....|....
gi 1191825913  861 ASVPAPAEGTAQAEAPAQYPSERL 884
Cdd:PRK07994   436 TKAKKSEPAAASRARPVNSALERL 459
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 30-175 5.91e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 5.91e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1191825913   30 ALEGPVTAIIPTWQALTALDLSHNSIS-EIDESVKLIPKIEFLDLSHNgvlvvdNLQHLYNLVHLDLSynklsSLEgvht 108
Cdd:PLN00113   391 SLEGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNN------NLQGRINSRKWDMP-----SLQ---- 455

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1191825913  109 klgnikTLNLAGN-LLGSLHGLHKLYSLVNLDLSNNRIEQMEEvRSIGSLPCLEHVALLNNPLS-IIPD 175
Cdd:PLN00113   456 ------MLSLARNkFFGGLPDSFGSKRLENLDLSRNQFSGAVP-RKLGSLSELMQLKLSENKLSgEIPD 517
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 812-878 6.36e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 41.03  E-value: 6.36e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1191825913  812 PVPALAPAEAPGLAKIPAPAEASEPALVLPEAPTEASASEETPAEASAGASVPAPAEGTAQAEAPAQ 878
Cdd:PRK12270    38 PGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAA 104
LRR_8 pfam13855
Leucine rich repeat;
42-76 6.96e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 6.96e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191825913   42 WQALTALDLSHNSISEIDE--SVKLiPKIEFLDLSHN 76
Cdd:pfam13855   24 LSNLKVLDLSNNLLTTLSPgaFSGL-PSLRYLDLSGN 59
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 134-170 8.26e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 8.26e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1191825913  134 SLVNLDLSNNRIEqmeEVRSIGSLPCLEHVALLNNPL 170
Cdd:pfam12799    2 NLEVLDLSNNQIT---DIPPLAKLPNLETLDLSGNNK 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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