NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1207159545|ref|XP_021324550|]
View 

calpastatin isoform X20 [Danio rerio]

Protein Classification

calpastatin family protein( domain architecture ID 10286369)

calpastatin family protein specifically inhibits calpain (calcium-dependent cysteine protease)

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
353-498 7.89e-22

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


:

Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 91.61  E-value: 7.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545 353 AMDILSGDFTTPASAPVVKAPVPPAQDTKKHAAvpektkdipktkadaLSSDFVAPAHSAPKVSSAAPKTIPPGPPqtPD 432
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAAAA---------------LAGEVVSAASASSVKSAAPPPEKKRKDE--VM 63
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207159545 433 EDPFSALGDTLSAPEPpKKQPDLKPKDIVHEKdVTSKKGVRVGERDDTLPPEYR--FKEEDLKKYPPP 498
Cdd:pfam00748  64 DDALDALSDTLGGREP-DPEEDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
509-651 3.64e-13

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


:

Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 66.95  E-value: 3.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545 509 ALDILSGDFTTPSAPSAVSPASKSSAKSSDSalDALAGDFVASSSASSVHSAVSGPPRSDRLLsdGTSSALDALSETLGD 588
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAA--AALAGEVVSAASASSVKSAAPPPEKKRKDE--VMDDALDALSDTLGG 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207159545 589 IKAAPEPaPVLPKTVVKEKtVIEERVSKPGERDDSLPPDQRftaedrkaFEEAKKKDAKPKQP 651
Cdd:pfam00748  77 REPDPEE-DKPPVDKVKEK-AKEEKREKLGERDDTIPPEYR--------LLPAKDKDGKPLLP 129
Calpain_inhib super family cl08287
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
186-342 3.22e-12

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


The actual alignment was detected with superfamily member pfam00748:

Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 64.26  E-value: 3.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545 186 ALESLSSTFVSPAQAAPKKTDVKTETigavdvKSAGTTNfappppsQQKQPASSQAAAVTKSPAPPADKKAKMEthaqpa 265
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAE------KSSAAAA-------LAGEVVSAASASSVKSAAPPPEKKRKDE------ 61
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207159545 266 kaktesdssISLDALDALSDTLGASKPPQKlPELKPGQIVDEKkQTSEKGVRVGERDDTLPPQYR--FKEEDLKKYPPP 342
Cdd:pfam00748  62 ---------VMDDALDALSDTLGGREPDPE-EDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib super family cl08287
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
59-168 2.82e-09

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


The actual alignment was detected with superfamily member pfam00748:

Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 55.78  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545  59 ATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQVEVGPSAAK-----ADDPFDALSGTLPSSQPLAPKVHYTGPEIKEpK 133
Cdd:pfam00748  16 PKPKKPAPKAEKSSAAAALAGEVVSAASASSVKSAAPPPEKKrkdevMDDALDALSDTLGGREPDPEEDKPPVDKVKE-K 94
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1207159545 134 LKSEKGVLCGERDDTLPPGYRKEDLEKKHGAGVPA 168
Cdd:pfam00748  95 AKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 129
 
Name Accession Description Interval E-value
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
353-498 7.89e-22

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 91.61  E-value: 7.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545 353 AMDILSGDFTTPASAPVVKAPVPPAQDTKKHAAvpektkdipktkadaLSSDFVAPAHSAPKVSSAAPKTIPPGPPqtPD 432
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAAAA---------------LAGEVVSAASASSVKSAAPPPEKKRKDE--VM 63
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207159545 433 EDPFSALGDTLSAPEPpKKQPDLKPKDIVHEKdVTSKKGVRVGERDDTLPPEYR--FKEEDLKKYPPP 498
Cdd:pfam00748  64 DDALDALSDTLGGREP-DPEEDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
509-651 3.64e-13

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 66.95  E-value: 3.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545 509 ALDILSGDFTTPSAPSAVSPASKSSAKSSDSalDALAGDFVASSSASSVHSAVSGPPRSDRLLsdGTSSALDALSETLGD 588
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAA--AALAGEVVSAASASSVKSAAPPPEKKRKDE--VMDDALDALSDTLGG 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207159545 589 IKAAPEPaPVLPKTVVKEKtVIEERVSKPGERDDSLPPDQRftaedrkaFEEAKKKDAKPKQP 651
Cdd:pfam00748  77 REPDPEE-DKPPVDKVKEK-AKEEKREKLGERDDTIPPEYR--------LLPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
186-342 3.22e-12

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 64.26  E-value: 3.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545 186 ALESLSSTFVSPAQAAPKKTDVKTETigavdvKSAGTTNfappppsQQKQPASSQAAAVTKSPAPPADKKAKMEthaqpa 265
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAE------KSSAAAA-------LAGEVVSAASASSVKSAAPPPEKKRKDE------ 61
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207159545 266 kaktesdssISLDALDALSDTLGASKPPQKlPELKPGQIVDEKkQTSEKGVRVGERDDTLPPQYR--FKEEDLKKYPPP 342
Cdd:pfam00748  62 ---------VMDDALDALSDTLGGREPDPE-EDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
59-168 2.82e-09

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 55.78  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545  59 ATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQVEVGPSAAK-----ADDPFDALSGTLPSSQPLAPKVHYTGPEIKEpK 133
Cdd:pfam00748  16 PKPKKPAPKAEKSSAAAALAGEVVSAASASSVKSAAPPPEKKrkdevMDDALDALSDTLGGREPDPEEDKPPVDKVKE-K 94
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1207159545 134 LKSEKGVLCGERDDTLPPGYRKEDLEKKHGAGVPA 168
Cdd:pfam00748  95 AKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 129
PRK10263 PRK10263
DNA translocase FtsK; Provisional
32-214 7.60e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.07  E-value: 7.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545   32 YPIESQQVTPTTTSQVSTVKPAQYEKGATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQVEVGPSAAKADDP---FDAL 108
Cdd:PRK10263   380 YPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQqstFAPQ 459
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545  109 SGTLPSS---QPLAPKVHYTGPEIKEPKLKSEKGVLCGERDDTLPPGYRKEDLEKKHG------AGVPAGVPEKPKE-VP 178
Cdd:PRK10263   460 STYQTEQtyqQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRArereqlAAWYQPIPEPVKEpEP 539
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1207159545  179 KPISTDDALESLSSTFVSPAQAAPKKTDVKTETIGA 214
Cdd:PRK10263   540 IKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLAT 575
 
Name Accession Description Interval E-value
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
353-498 7.89e-22

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 91.61  E-value: 7.89e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545 353 AMDILSGDFTTPASAPVVKAPVPPAQDTKKHAAvpektkdipktkadaLSSDFVAPAHSAPKVSSAAPKTIPPGPPqtPD 432
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAAAA---------------LAGEVVSAASASSVKSAAPPPEKKRKDE--VM 63
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1207159545 433 EDPFSALGDTLSAPEPpKKQPDLKPKDIVHEKdVTSKKGVRVGERDDTLPPEYR--FKEEDLKKYPPP 498
Cdd:pfam00748  64 DDALDALSDTLGGREP-DPEEDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
509-651 3.64e-13

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 66.95  E-value: 3.64e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545 509 ALDILSGDFTTPSAPSAVSPASKSSAKSSDSalDALAGDFVASSSASSVHSAVSGPPRSDRLLsdGTSSALDALSETLGD 588
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAEKSSAA--AALAGEVVSAASASSVKSAAPPPEKKRKDE--VMDDALDALSDTLGG 76
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1207159545 589 IKAAPEPaPVLPKTVVKEKtVIEERVSKPGERDDSLPPDQRftaedrkaFEEAKKKDAKPKQP 651
Cdd:pfam00748  77 REPDPEE-DKPPVDKVKEK-AKEEKREKLGERDDTIPPEYR--------LLPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
186-342 3.22e-12

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 64.26  E-value: 3.22e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545 186 ALESLSSTFVSPAQAAPKKTDVKTETigavdvKSAGTTNfappppsQQKQPASSQAAAVTKSPAPPADKKAKMEthaqpa 265
Cdd:pfam00748   1 LLDALSSDFTSSSAAPKPKKPAPKAE------KSSAAAA-------LAGEVVSAASASSVKSAAPPPEKKRKDE------ 61
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1207159545 266 kaktesdssISLDALDALSDTLGASKPPQKlPELKPGQIVDEKkQTSEKGVRVGERDDTLPPQYR--FKEEDLKKYPPP 342
Cdd:pfam00748  62 ---------VMDDALDALSDTLGGREPDPE-EDKPPVDKVKEK-AKEEKREKLGERDDTIPPEYRllPAKDKDGKPLLP 129
Calpain_inhib pfam00748
Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.
59-168 2.82e-09

Calpain inhibitor; This region is found multiple times in calpain inhibitor proteins.


Pssm-ID: 459923 [Multi-domain]  Cd Length: 129  Bit Score: 55.78  E-value: 2.82e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545  59 ATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQVEVGPSAAK-----ADDPFDALSGTLPSSQPLAPKVHYTGPEIKEpK 133
Cdd:pfam00748  16 PKPKKPAPKAEKSSAAAALAGEVVSAASASSVKSAAPPPEKKrkdevMDDALDALSDTLGGREPDPEEDKPPVDKVKE-K 94
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1207159545 134 LKSEKGVLCGERDDTLPPGYRKEDLEKKHGAGVPA 168
Cdd:pfam00748  95 AKEEKREKLGERDDTIPPEYRLLPAKDKDGKPLLP 129
PRK10263 PRK10263
DNA translocase FtsK; Provisional
32-214 7.60e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.07  E-value: 7.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545   32 YPIESQQVTPTTTSQVSTVKPAQYEKGATQSSTAAATVKSGAGDPATTQKGSSQVKPQVQVEVGPSAAKADDP---FDAL 108
Cdd:PRK10263   380 YPQQSQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQqstFAPQ 459
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207159545  109 SGTLPSS---QPLAPKVHYTGPEIKEPKLKSEKGVLCGERDDTLPPGYRKEDLEKKHG------AGVPAGVPEKPKE-VP 178
Cdd:PRK10263   460 STYQTEQtyqQPAAQEPLYQQPQPVEQQPVVEPEPVVEETKPARPPLYYFEEVEEKRArereqlAAWYQPIPEPVKEpEP 539
                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1207159545  179 KPISTDDALESLSSTFVSPAQAAPKKTDVKTETIGA 214
Cdd:PRK10263   540 IKSSLKAPSVAAVPPVEAAAAVSPLASGVKKATLAT 575
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH