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Conserved domains on  [gi|1207177251|ref|XP_021332337|]
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zinc finger protein 436 [Danio rerio]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-300 3.27e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 3.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251  84 CDRCGKSFTRKERLKEHTRIHTGEKPFACAQ--CGKRFGCSSNLKQHMMTHTGEKPHKCDQCGKT--FLKPSDLISHLRV 159
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 160 HTNeKPYSCSVCGKSFTHQQYLRKHQKFHSGVREYVCFEC-EKTFIRVEELKRHQRIHTGEKPYKCSHCDTSFsqiqhlr 238
Cdd:COG5048   116 NSN-DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL------- 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207177251 239 THQRIHTGEKPHKCSHCDKRFTQLGVLKTHERIHTGEKPYTCDQCFRSFTYSLQLKKHMKIH 300
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS 249
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-300 3.27e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 3.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251  84 CDRCGKSFTRKERLKEHTRIHTGEKPFACAQ--CGKRFGCSSNLKQHMMTHTGEKPHKCDQCGKT--FLKPSDLISHLRV 159
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 160 HTNeKPYSCSVCGKSFTHQQYLRKHQKFHSGVREYVCFEC-EKTFIRVEELKRHQRIHTGEKPYKCSHCDTSFsqiqhlr 238
Cdd:COG5048   116 NSN-DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL------- 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207177251 239 THQRIHTGEKPHKCSHCDKRFTQLGVLKTHERIHTGEKPYTCDQCFRSFTYSLQLKKHMKIH 300
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS 249
zf-H2C2_2 pfam13465
Zinc-finger double domain;
124-147 1.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.83e-04
                          10        20
                  ....*....|....*....|....
gi 1207177251 124 NLKQHMMTHTGEKPHKCDQCGKTF 147
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-300 3.27e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.70  E-value: 3.27e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251  84 CDRCGKSFTRKERLKEHTRIHTGEKPFACAQ--CGKRFGCSSNLKQHMMTHTGEKPHKCDQCGKT--FLKPSDLISHLRV 159
Cdd:COG5048    36 CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLSSSSS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 160 HTNeKPYSCSVCGKSFTHQQYLRKHQKFHSGVREYVCFEC-EKTFIRVEELKRHQRIHTGEKPYKCSHCDTSFsqiqhlr 238
Cdd:COG5048   116 NSN-DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL------- 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1207177251 239 THQRIHTGEKPHKCSHCDKRFTQLGVLKTHERIHTGEKPYTCDQCFRSFTYSLQLKKHMKIH 300
Cdd:COG5048   188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLS 249
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-287 8.73e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.00  E-value: 8.73e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 136 KPHKCDQCGKTFLKPSDLISHLR--VHTNE--KPYSC--SVCGKSFTHQQYLRKHQKFHSGVREYVCFECEKTFIRVEEL 209
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 210 K-------RHQRIHTGEKPYKCSH--CDTSFSQIQHLRTHQRIHTGEKPH--KCSHCDKRFTQLGVLKTHERIHTGEKPY 278
Cdd:COG5048   368 NneppqslQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447


                  ....*....
gi 1207177251 279 TCDQCFRSF 287
Cdd:COG5048   448 LCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
131-290 1.45e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 1.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 131 THTGEKPHKCDQCGKTFLKPSDLISHLRVHTNEKPYSCSVCG----KSFTHQQYLRKHQKFHSGVREYVCFECEKTfiRV 206
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSSLSSSDSSSSASESPRSSLPT--AS 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 207 EELKRHQRIHTGE-----KPYKCSHCDTSFSQIQHLRTHQR--IHTGE--KPHKCSH--CDKRFTQLGVLKTHERIHTGE 275
Cdd:COG5048   270 SQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSI 349

                         170
                  ....*....|....*
gi 1207177251 276 KPYTCDQCFRSFTYS 290
Cdd:COG5048   350 SPAKEKLLNSSSKFS 364
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
82-257 4.11e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 4.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251  82 FTCDRCGKSFTRKERLKEHTR--IHTGE--KPFAC--AQCGKRFGCSSNLKQHMMTHTGEKPHKC--DQCGKTFLKPSDL 153
Cdd:COG5048   290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLNN 369

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 154 ISHLRVH-----TNEKPYSCSV--CGKSFTHQQYLRKHQKFHSGVREYVCfecektfirveelkrhqrihtgekpyKCSH 226
Cdd:COG5048   370 EPPQSLQqykdlKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNC--------------------------KNPP 423

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1207177251 227 CDTSFSQIQHLRTHQRIHTGEKPHKCSHCDK 257
Cdd:COG5048   424 CSKSFNRHYNLIPHKKIHTNHAPLLCSILKS 454
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
178-255 5.46e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.69  E-value: 5.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 178 QQYLRKHQKFHSGVREYVCFECEKTFIRVEELKRHQRIHTGEKPYKCSH--CDTSFSQIQHLRTHQRIHTGEKPHKCSHC 255
Cdd:COG5048    18 STPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKS 97
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 106-189 8.05e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 8.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 106 GEKPFACA--QCGKRFGCSSNLKQHMMT-HTGEKPHKcdqcgktflkPSDLISHLRVHTNEKPYSCSVCGKSFTHQQYLR 182
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE----------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                  ....*..
gi 1207177251 183 KHQKfHS 189
Cdd:COG5189   416 YHRK-HS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
124-147 1.83e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 1.83e-04
                          10        20
                  ....*....|....*....|....
gi 1207177251 124 NLKQHMMTHTGEKPHKCDQCGKTF 147
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
236-261 2.01e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.01e-04
                          10        20
                  ....*....|....*....|....*.
gi 1207177251 236 HLRTHQRIHTGEKPHKCSHCDKRFTQ 261
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
63-301 4.46e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 4.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251  63 WKSFRRPNNHITIHNGEKAFTCDRCGKSFTRKERLKEHTRIHTGEKPFACAQCGKRFGCSSNLKQHMMTHTGEKPHKCDQ 142
Cdd:COG5048   180 PSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASE 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 143 CGKTFLKPSDLISHLRVHTNE-------KPYSCSVCGKSFTHQQYLRKHQ--KFHSG--VREYVCFE--CEKTFIRVEEL 209
Cdd:COG5048   260 SPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGesLKPFSCPYslCGKLFSRNDAL 339

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 210 KRHQRIHTGEKPYKC--SHCDTSFSQIQHLRTHQRIHTGEKPHK-----CSH--CDKRFTQLGVLKTHERIHTGEKPY-- 278
Cdd:COG5048   340 KRHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNdkkseTLSnsCIRNFKRDSNLSLHIITHLSFRPYnc 419

                         250       260
                  ....*....|....*....|...
gi 1207177251 279 TCDQCFRSFTYSLQLKKHMKIHT 301
Cdd:COG5048   420 KNPPCSKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
208-233 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....*.
gi 1207177251 208 ELKRHQRIHTGEKPYKCSHCDTSFSQ 233
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
136-254 2.15e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.68  E-value: 2.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1207177251 136 KPHKCDQCGKTFLKPSDLISHLRVHTNEKPYSCSVCGksfthqqylrkhqkfhsgvreyvcfeCEKTFIRVEELKRHQRI 215
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSG--------------------------CDKSFSRPLELSRHLRT 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1207177251 216 HTGEKPYKCSHC------DTSFSQIQHLRTHQRIHTGEKPHKCSH 254
Cdd:COG5048    86 HHNNPSDLNSKSlplsnsKASSSSLSSSSSNSNDNNLLSSHSLPP 130
zf-H2C2_2 pfam13465
Zinc-finger double domain;
96-119 2.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 2.93e-03
                          10        20
                  ....*....|....*....|....
gi 1207177251  96 RLKEHTRIHTGEKPFACAQCGKRF 119
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
108-169 7.81e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 37.75  E-value: 7.81e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1207177251 108 KPFACAQCGKRFGCSSNLKQHMMTHTGEKPHKC--DQCGKTFLKPSDLISHLRVHTNEKPYSCS 169
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS 95
zf-H2C2_2 pfam13465
Zinc-finger double domain;
152-177 9.73e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.11  E-value: 9.73e-03
                          10        20
                  ....*....|....*....|....*.
gi 1207177251 152 DLISHLRVHTNEKPYSCSVCGKSFTH 177
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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