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Conserved domains on  [gi|1227962979|ref|XP_021942937|]
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uncharacterized protein LOC110841572 [Zootermopsis nevadensis]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 10607647)

HEAT repeat domain-containing protein similar to Saccharomyces cerevisiae importin subunit beta-2, also called karyopherin-104, that functions as a nuclear transport receptor for arginine/glycine-rich nuclear localization signals (rg-NLS) and PY-NLS in cargo substrates

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 71-126 5.02e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


:

Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 48.90  E-value: 5.02e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1227962979  71 HAVREAACACIAELAsKIHPQTVQPHVERLLNTLLVCFQDDSWPVRDAACLACGNF 126
Cdd:pfam13513   1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
46-165 2.71e-05

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227962979  46 AGKQLVQKYISHTVDYYILATESDNHAVREAACACIAELASkihPQTVQPhverllntLLVCFQDDSWPVRDAACLACGN 125
Cdd:COG1413     5 AARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGD---PRAVPA--------LLEALKDPDPEVRAAAAEALGR 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1227962979 126 FilsfpdESQAALPSLYPMffrnLEDPIPSVRQGAASSLA 165
Cdd:COG1413    74 I------GDPEAVPALIAA----LKDEDPEVRRAAAEALG 103
 
Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 71-126 5.02e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 48.90  E-value: 5.02e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1227962979  71 HAVREAACACIAELAsKIHPQTVQPHVERLLNTLLVCFQDDSWPVRDAACLACGNF 126
Cdd:pfam13513   1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT COG1413
HEAT repeat [General function prediction only];
63-166 1.62e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227962979  63 ILATESDNHAVREAACACIAELASkihpqtvqphvERLLNTLLVCFQDDSWPVRDAACLACGNFilsfpdESQAALPSLY 142
Cdd:COG1413    53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALGRL------GDPAAVPALL 115

                          90       100
                  ....*....|....*....|....
gi 1227962979 143 PMffrnLEDPIPSVRQGAASSLAS 166
Cdd:COG1413   116 EA----LKDPDWEVRRAAARALGR 135
HEAT COG1413
HEAT repeat [General function prediction only];
46-165 2.71e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227962979  46 AGKQLVQKYISHTVDYYILATESDNHAVREAACACIAELASkihPQTVQPhverllntLLVCFQDDSWPVRDAACLACGN 125
Cdd:COG1413     5 AARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGD---PRAVPA--------LLEALKDPDPEVRAAAAEALGR 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1227962979 126 FilsfpdESQAALPSLYPMffrnLEDPIPSVRQGAASSLA 165
Cdd:COG1413    74 I------GDPEAVPALIAA----LKDEDPEVRRAAAEALG 103
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 113-167 2.33e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.81  E-value: 2.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1227962979 113 WPVRDAACLACGNFILSFPDESQAALPSLYPMFFRNLEDPIPSVRQGAASSLASV 167
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
 
Name Accession Description Interval E-value
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 71-126 5.02e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 48.90  E-value: 5.02e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1227962979  71 HAVREAACACIAELAsKIHPQTVQPHVERLLNTLLVCFQDDSWPVRDAACLACGNF 126
Cdd:pfam13513   1 WRVREAAALALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 64-165 8.12e-06

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.87  E-value: 8.12e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227962979  64 LATESDNHAVREAACACIAELASkihpqtvqphvERLLNTLLVCFQDDSWPVRDAACLACGNFilsfpdESQAALPSLYP 143
Cdd:pfam13646   7 ALLRDPDPEVRAAAIRALGRIGD-----------PEAVPALLELLKDEDPAVRRAAAEALGKI------GDPEALPALLE 69

                          90       100
                  ....*....|....*....|..
gi 1227962979 144 MFfrnLEDPIPSVRQGAASSLA 165
Cdd:pfam13646  70 LL---RDDDDDVVRAAAAEALA 88
HEAT COG1413
HEAT repeat [General function prediction only];
63-166 1.62e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227962979  63 ILATESDNHAVREAACACIAELASkihpqtvqphvERLLNTLLVCFQDDSWPVRDAACLACGNFilsfpdESQAALPSLY 142
Cdd:COG1413    53 LEALKDPDPEVRAAAAEALGRIGD-----------PEAVPALIAALKDEDPEVRRAAAEALGRL------GDPAAVPALL 115

                          90       100
                  ....*....|....*....|....
gi 1227962979 143 PMffrnLEDPIPSVRQGAASSLAS 166
Cdd:COG1413   116 EA----LKDPDWEVRRAAARALGR 135
HEAT COG1413
HEAT repeat [General function prediction only];
46-165 2.71e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 43.46  E-value: 2.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227962979  46 AGKQLVQKYISHTVDYYILATESDNHAVREAACACIAELASkihPQTVQPhverllntLLVCFQDDSWPVRDAACLACGN 125
Cdd:COG1413     5 AARALGRLGDPAAVPALIAALADEDPDVRAAAARALGRLGD---PRAVPA--------LLEALKDPDPEVRAAAAEALGR 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1227962979 126 FilsfpdESQAALPSLYPMffrnLEDPIPSVRQGAASSLA 165
Cdd:COG1413    74 I------GDPEAVPALIAA----LKDEDPEVRRAAAEALG 103
HEAT COG1413
HEAT repeat [General function prediction only];
73-223 3.25e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 40.38  E-value: 3.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227962979  73 VREAACACIAELASkihPQTVQPhverllntLLVCFQDDSWPVRDAACLACGNFilsfpdESQAALPSLYPMffrnLEDP 152
Cdd:COG1413     1 VRRAAARALGRLGD---PAAVPA--------LIAALADEDPDVRAAAARALGRL------GDPRAVPALLEA----LKDP 59

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1227962979 153 IPSVRQGAASSLASVvraYGQEALAVVMEKVTAGLKGVRNQPADSERylDLDHSQATFGVVKRLRDNDPEV 223
Cdd:COG1413    60 DPEVRAAAAEALGRI---GDPEAVPALIAALKDEDPEVRRAAAEALG--RLGDPAAVPALLEALKDPDWEV 125
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 113-167 2.33e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.81  E-value: 2.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1227962979 113 WPVRDAACLACGNFILSFPDESQAALPSLYPMFFRNLEDPIPSVRQGAASSLASV 167
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 100-127 2.62e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 35.20  E-value: 2.62e-03
                          10        20
                  ....*....|....*....|....*...
gi 1227962979 100 LLNTLLVCFQDDSWPVRDAACLACGNFI 127
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELA 28
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 97-181 2.71e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 36.55  E-value: 2.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1227962979  97 VERLLNTLLvcfQDDSWPVRDAACLACGNFIlsfpdeSQAALPSLYPMffrnLEDPIPSVRQGAASSLASVvraYGQEAL 176
Cdd:pfam13646   1 LPALLQALL---RDPDPEVRAAAIRALGRIG------DPEAVPALLEL----LKDEDPAVRRAAAEALGKI---GDPEAL 64


                  ....*
gi 1227962979 177 AVVME 181
Cdd:pfam13646  65 PALLE 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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