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Conserved domains on  [gi|1370465771|ref|XP_024305522|]
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A-kinase anchor protein 6 isoform X1 [Homo sapiens]

Protein Classification

spectrin repeat-containing protein( domain architecture ID 10242646)

spectrin repeat-containing protein such as plectin, a prototypical plakin that tethers intermediate filaments to membrane-associated complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 962-1190 7.11e-09

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


:

Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 58.23  E-value: 7.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  962 LLDFDSEYQELWDWLIDMESLVMD---SHDLMMSEEQQQHLyKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEK 1038
Cdd:cd00176      2 LQQFLRDADELEAWLSEKEELLSStdyGDDLESVEALLKKH-EALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQER 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771 1039 VDSINEKWELLGKTL---GEKIQDTMAGHSGSspRDLLspesgslvrqlevrikELKGWLRDTELFIfnscLRQEKEGTM 1115
Cdd:cd00176     81 LEELNQRWEELRELAeerRQRLEEALDLQQFF--RDAD----------------DLEQWLEEKEAAL----ASEDLGKDL 138

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465771 1116 NT-EKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQliivNLERRWEAIVMQAVQWQTRLQ 1190
Cdd:cd00176    139 ESvEELLKKHKELEEELEAHEPRLKSLNELAEELLEEGHPDADEEIEEKLE----ELNERWEELLELAEERQKKLE 210
SPEC super family cl02488
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 784-888 1.71e-04

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


The actual alignment was detected with superfamily member cd00176:

Pssm-ID: 413338 [Multi-domain]  Cd Length: 213  Bit Score: 45.13  E-value: 1.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  784 FVNKLDEFIQWLNEAMETTENWTPPKaEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELiASHKAEGLKDMLR 863
Cdd:cd00176      5 FLRDADELEAWLSEKEELLSSTDYGD-DLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEE-GHPDAEEIQERLE 82

                           90       100
                   ....*....|....*....|....*
gi 1370465771  864 MIASQWKELQRQIKRQHSWILRALD 888
Cdd:cd00176     83 ELNQRWEELRELAEERRQRLEEALD 107
 
Name Accession Description Interval E-value
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 962-1190 7.11e-09

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 58.23  E-value: 7.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  962 LLDFDSEYQELWDWLIDMESLVMD---SHDLMMSEEQQQHLyKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEK 1038
Cdd:cd00176      2 LQQFLRDADELEAWLSEKEELLSStdyGDDLESVEALLKKH-EALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQER 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771 1039 VDSINEKWELLGKTL---GEKIQDTMAGHSGSspRDLLspesgslvrqlevrikELKGWLRDTELFIfnscLRQEKEGTM 1115
Cdd:cd00176     81 LEELNQRWEELRELAeerRQRLEEALDLQQFF--RDAD----------------DLEQWLEEKEAAL----ASEDLGKDL 138

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465771 1116 NT-EKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQliivNLERRWEAIVMQAVQWQTRLQ 1190
Cdd:cd00176    139 ESvEELLKKHKELEEELEAHEPRLKSLNELAEELLEEGHPDADEEIEEKLE----ELNERWEELLELAEERQKKLE 210
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 784-888 1.71e-04

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 45.13  E-value: 1.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  784 FVNKLDEFIQWLNEAMETTENWTPPKaEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELiASHKAEGLKDMLR 863
Cdd:cd00176      5 FLRDADELEAWLSEKEELLSSTDYGD-DLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEE-GHPDAEEIQERLE 82

                           90       100
                   ....*....|....*....|....*
gi 1370465771  864 MIASQWKELQRQIKRQHSWILRALD 888
Cdd:cd00176     83 ELNQRWEELRELAEERRQRLEEALD 107
SPEC smart00150
Spectrin repeats;
965-1056 9.23e-04

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 40.78  E-value: 9.23e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771   965 FDSEYQELWDWLIDMESLVMD---SHDLMMSEEQQQHLyKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDS 1041
Cdd:smart00150    3 FLRDADELEAWLEEKEQLLASedlGKDLESVEALLKKH-EAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLEE 81

                            90
                    ....*....|....*
gi 1370465771  1042 INEKWELLGKTLGEK 1056
Cdd:smart00150   82 LNERWEELKELAEER 96
Spectrin pfam00435
Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in ...
 784-885 1.19e-03

Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin and dystrophin. The sequence repeat used in this family is taken from the structural repeat in reference. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteriztic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in multiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.


Pssm-ID: 395348 [Multi-domain]  Cd Length: 105  Bit Score: 40.38  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  784 FVNKLDEFIQWLNEAMETTeNWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELiASHKAEGLKDMLR 863
Cdd:pfam00435    6 FFRDADDLESWIEEKEALL-SSEDYGKDLESVQALLKKHKALEAELAAHQDRVEALNELAEKLIDE-GHYASEEIQERLE 83

                           90       100
                   ....*....|....*....|..
gi 1370465771  864 MIASQWKELQRQIKRQHSWILR 885
Cdd:pfam00435   84 ELNERWEQLLELAAERKQKLEE 105
SPEC smart00150
Spectrin repeats;
784-883 2.97e-03

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 39.24  E-value: 2.97e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771   784 FVNKLDEFIQWLNEaMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAEgLKDMLR 863
Cdd:smart00150    3 FLRDADELEAWLEE-KEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEE-IEERLE 80

                            90       100
                    ....*....|....*....|
gi 1370465771   864 MIASQWKELQRQIKRQHSWI 883
Cdd:smart00150   81 ELNERWEELKELAEERRQKL 100
 
Name Accession Description Interval E-value
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 962-1190 7.11e-09

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 58.23  E-value: 7.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  962 LLDFDSEYQELWDWLIDMESLVMD---SHDLMMSEEQQQHLyKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEK 1038
Cdd:cd00176      2 LQQFLRDADELEAWLSEKEELLSStdyGDDLESVEALLKKH-EALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQER 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771 1039 VDSINEKWELLGKTL---GEKIQDTMAGHSGSspRDLLspesgslvrqlevrikELKGWLRDTELFIfnscLRQEKEGTM 1115
Cdd:cd00176     81 LEELNQRWEELRELAeerRQRLEEALDLQQFF--RDAD----------------DLEQWLEEKEAAL----ASEDLGKDL 138

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370465771 1116 NT-EKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQliivNLERRWEAIVMQAVQWQTRLQ 1190
Cdd:cd00176    139 ESvEELLKKHKELEEELEAHEPRLKSLNELAEELLEEGHPDADEEIEEKLE----ELNERWEELLELAEERQKKLE 210
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 784-888 1.71e-04

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 45.13  E-value: 1.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  784 FVNKLDEFIQWLNEAMETTENWTPPKaEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELiASHKAEGLKDMLR 863
Cdd:cd00176      5 FLRDADELEAWLSEKEELLSSTDYGD-DLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEE-GHPDAEEIQERLE 82

                           90       100
                   ....*....|....*....|....*
gi 1370465771  864 MIASQWKELQRQIKRQHSWILRALD 888
Cdd:cd00176     83 ELNQRWEELRELAEERRQRLEEALD 107
SPEC smart00150
Spectrin repeats;
965-1056 9.23e-04

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 40.78  E-value: 9.23e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771   965 FDSEYQELWDWLIDMESLVMD---SHDLMMSEEQQQHLyKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDS 1041
Cdd:smart00150    3 FLRDADELEAWLEEKEQLLASedlGKDLESVEALLKKH-EAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLEE 81

                            90
                    ....*....|....*
gi 1370465771  1042 INEKWELLGKTLGEK 1056
Cdd:smart00150   82 LNERWEELKELAEER 96
Spectrin pfam00435
Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in ...
 784-885 1.19e-03

Spectrin repeat; Spectrin repeat-domains are found in several proteins involved in cytoskeletal structure. These include spectrin, alpha-actinin and dystrophin. The sequence repeat used in this family is taken from the structural repeat in reference. The spectrin domain- repeat forms a three helix bundle. The second helix is interrupted by proline in some sequences. The repeats are defined by a characteriztic tryptophan (W) residue at position 17 in helix A and a leucine (L) at 2 residues from the carboxyl end of helix C. Although the domain occurs in multiple repeats along sequences, the domains are actually stable on their own - ie they act, biophysically, like domains rather than repeats that along function when aggregated.


Pssm-ID: 395348 [Multi-domain]  Cd Length: 105  Bit Score: 40.38  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  784 FVNKLDEFIQWLNEAMETTeNWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELiASHKAEGLKDMLR 863
Cdd:pfam00435    6 FFRDADDLESWIEEKEALL-SSEDYGKDLESVQALLKKHKALEAELAAHQDRVEALNELAEKLIDE-GHYASEEIQERLE 83

                           90       100
                   ....*....|....*....|..
gi 1370465771  864 MIASQWKELQRQIKRQHSWILR 885
Cdd:pfam00435   84 ELNERWEQLLELAAERKQKLEE 105
SPEC smart00150
Spectrin repeats;
1082-1190 1.42e-03

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 40.01  E-value: 1.42e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  1082 RQLEVRIKELKGWLRDTELFifnscLRQEKEGT--MNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDREtcnlnA 1159
Cdd:smart00150    1 QQFLRDADELEAWLEEKEQL-----LASEDLGKdlESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGH-----P 70

                            90       100       110
                    ....*....|....*....|....*....|.
gi 1370465771  1160 DHQPMQLIIVNLERRWEAIVMQAVQWQTRLQ 1190
Cdd:smart00150   71 DAEEIEERLEELNERWEELKELAEERRQKLE 101
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 758-887 2.02e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 42.05  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771  758 SALIQKLMQDIQHQ-DNYEAIWE----------KIEGFVNKLDEFIQWLNEAMETTENwTPPKAEMDDLKLYLETHLSFK 826
Cdd:cd00176     74 AEEIQERLEELNQRwEELRELAEerrqrleealDLQQFFRDADDLEQWLEEKEAALAS-EDLGKDLESVEELLKKHKELE 152

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370465771  827 LNVDSHCALKEAVEEEGHQLLELIASHKAEGLKDMLRMIASQWKELQRQIKRQHSWILRAL 887
Cdd:cd00176    153 EELEAHEPRLKSLNELAEELLEEGHPDADEEIEEKLEELNERWEELLELAEERQKKLEEAL 213
SPEC smart00150
Spectrin repeats;
784-883 2.97e-03

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 39.24  E-value: 2.97e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771   784 FVNKLDEFIQWLNEaMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAEgLKDMLR 863
Cdd:smart00150    3 FLRDADELEAWLEE-KEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEE-IEERLE 80

                            90       100
                    ....*....|....*....|
gi 1370465771   864 MIASQWKELQRQIKRQHSWI 883
Cdd:smart00150   81 ELNERWEELKELAEERRQKL 100
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
 1080-1204 3.40e-03

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 41.28  E-value: 3.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370465771 1080 LVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTmntEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDREtcnlnA 1159
Cdd:cd00176      1 KLQQFLRDADELEAWLSEKEELLSSTDYGDDLESV---EALLKKHEALEAELAAHEERVEALNELGEQLIEEGH-----P 72

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1370465771 1160 DHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVID 1204
Cdd:cd00176     73 DAEEIQERLEELNQRWEELRELAEERRQRLEEALDLQQFFRDADD 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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