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Conserved domains on  [gi|1370473424|ref|XP_024306933|]
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cadherin-20 isoform X1 [Homo sapiens]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 733-792 9.32e-33

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 120.33  E-value: 9.32e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 733 ADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYG 792
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 394-490 1.09e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 1.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 394 YFVEVPEDVAIGTTIQIISAKDPDVTNNS-IRYSIDrSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1370473424 473 SQVGSVPVTIKVLDVNDN 490
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-270 2.94e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 2.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 169 PYVATVPEMSPVGTSVIQVTATDADDptyGNSARVVYSILQGQP--YFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKD 246
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1370473424 247 MGGQlgGLAGTTTVNITLSDVNDN 270
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-385 1.80e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 278 HYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDIstDPNFqvGIITVKKPLSFESKKSYTLKVE--- 354
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTatd 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1370473424 355 GANPhlemrflnlgPFQDTTTVHISVEDVDE 385
Cdd:cd11304    77 GGGP----------PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-163 2.73e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424   85 SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEFIIKIQDINDNEP 163
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-595 1.27e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 498 YEAFVCENAKAGQLIQTVSAVDQDDPRNGQhFYYSLAPEAANNPnFTIrdnQDNTARILTRRSGFRQQeQSVFHLPILIA 577
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTAKPLDREE-QSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 1370473424 578 DSGQPVLSSTGTLTIQVC 595
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 733-792 9.32e-33

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 120.33  E-value: 9.32e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 733 ADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYG 792
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 394-490 1.09e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 1.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 394 YFVEVPEDVAIGTTIQIISAKDPDVTNNS-IRYSIDrSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1370473424 473 SQVGSVPVTIKVLDVNDN 490
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-270 2.94e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 2.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 169 PYVATVPEMSPVGTSVIQVTATDADDptyGNSARVVYSILQGQP--YFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKD 246
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1370473424 247 MGGQlgGLAGTTTVNITLSDVNDN 270
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-385 1.80e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 278 HYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDIstDPNFqvGIITVKKPLSFESKKSYTLKVE--- 354
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTatd 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1370473424 355 GANPhlemrflnlgPFQDTTTVHISVEDVDE 385
Cdd:cd11304    77 GGGP----------PLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
170-264 4.24e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.21  E-value: 4.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 170 YVATVPEMSPVGTSVIQVTATDADDPTygnSARVVYSILQGQPY--FSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKDM 247
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*..
gi 1370473424 248 GGQlgGLAGTTTVNITL 264
Cdd:pfam00028  77 GGP--PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
394-485 7.16e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.44  E-value: 7.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 394 YFVEVPEDVAIGTTIQIISAKDPDVTNNS-IRYSIdRSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGrIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1370473424 473 SQVGSVPVTIKVL 485
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 188-272 8.05e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 8.05e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  188 TATDADDptyGNSARVVYSILQG--QPYFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKDMGGQlgGLAGTTTVNITLS 265
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1370473424  266 DVNDNPP 272
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 412-492 4.05e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 4.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  412 SAKDPDVTNNS-IRYSIDrSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDN 490
Cdd:smart00112   1 SATDADSGENGkVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1370473424  491 AP 492
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-163 2.73e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424   85 SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEFIIKIQDINDNEP 163
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-595 1.27e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 498 YEAFVCENAKAGQLIQTVSAVDQDDPRNGQhFYYSLAPEAANNPnFTIrdnQDNTARILTRRSGFRQQeQSVFHLPILIA 577
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTAKPLDREE-QSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 1370473424 578 DSGQPVLSSTGTLTIQVC 595
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 80-161 3.74e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 3.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  80 VGKLH-SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRtGRPMEPESEFIIKIQD 157
Cdd:cd11304    16 VLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPLSSTATVTITVLD 94


                  ....
gi 1370473424 158 INDN 161
Cdd:cd11304    95 VNDN 98
Cadherin pfam00028
Cadherin domain;
498-595 4.44e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 4.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 498 YEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANnpNFTI-RDNQD-NTARILTRrsgfrqQEQSVFHLPIL 575
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG--NFRIdPDTGDiSTTKPLDR------ESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 1370473424 576 IADSGQPVLSSTGTLTIQVC 595
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 298-387 8.21e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 8.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  298 AKDLDEGINAEMKYTIVDGDGADAFDISTDPnfqvGIITVKKPLSFESKKSYTLKVE---GANPhlemrflnlgPFQDTT 374
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEatdGGGP----------PLSSTA 67

                           90
                   ....*....|....
gi 1370473424  375 TVHISVEDV-DEPP 387
Cdd:smart00112  68 TVTITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
279-381 2.11e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 279 YQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPnfqvGIITVKKPLSFESKKSYTLKVEGANp 358
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|...
gi 1370473424 359 hlemrfLNLGPFQDTTTVHISVE 381
Cdd:pfam00028  76 ------SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
73-156 2.30e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  73 TGTDPLYVGKlhSDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEF 151
Cdd:pfam00028  11 VGTEVLTVTA--TDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATV 87


                  ....*
gi 1370473424 152 IIKIQ 156
Cdd:pfam00028  88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 516-599 4.44e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 4.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  516 SAVDQDDPRNGQhFYYSLAPEAANNPnFTIRDNQDntarILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVC 595
Cdd:smart00112   1 SATDADSGENGK-VTYSILSGNDDGL-FSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....
gi 1370473424  596 SCDD 599
Cdd:smart00112  75 DVND 78
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 733-792 9.32e-33

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 120.33  E-value: 9.32e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 733 ADMDLWAPPFDSLQTYMFEGDGSVAGSLSSLQSATSDSEQSFDFLTDWGPRFRKLAELYG 792
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 394-490 1.09e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 118.96  E-value: 1.09e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 394 YFVEVPEDVAIGTTIQIISAKDPDVTNNS-IRYSIDrSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*...
gi 1370473424 473 SQVGSVPVTIKVLDVNDN 490
Cdd:cd11304    81 PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 169-270 2.94e-31

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 117.41  E-value: 2.94e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 169 PYVATVPEMSPVGTSVIQVTATDADDptyGNSARVVYSILQGQP--YFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKD 246
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTA-KPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1370473424 247 MGGQlgGLAGTTTVNITLSDVNDN 270
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 278-385 1.80e-24

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 98.15  E-value: 1.80e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 278 HYQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDIstDPNFqvGIITVKKPLSFESKKSYTLKVE--- 354
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTatd 76

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1370473424 355 GANPhlemrflnlgPFQDTTTVHISVEDVDE 385
Cdd:cd11304    77 GGGP----------PLSSTATVTITVLDVND 97
Cadherin pfam00028
Cadherin domain;
170-264 4.24e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 91.21  E-value: 4.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 170 YVATVPEMSPVGTSVIQVTATDADDPTygnSARVVYSILQGQPY--FSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKDM 247
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTT-KPLDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*..
gi 1370473424 248 GGQlgGLAGTTTVNITL 264
Cdd:pfam00028  77 GGP--PLSSTATVTITV 91
Cadherin pfam00028
Cadherin domain;
394-485 7.16e-22

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 90.44  E-value: 7.16e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 394 YFVEVPEDVAIGTTIQIISAKDPDVTNNS-IRYSIdRSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNP 472
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGrIFYSI-LGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1370473424 473 SQVGSVPVTIKVL 485
Cdd:pfam00028  80 PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 188-272 8.05e-22

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 90.10  E-value: 8.05e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  188 TATDADDptyGNSARVVYSILQG--QPYFSVDSKTGVIRTAlMNMDREAKEYYEVIIQAKDMGGQlgGLAGTTTVNITLS 265
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTT-KPLDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1370473424  266 DVNDNPP 272
Cdd:smart00112  75 DVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 412-492 4.05e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.18  E-value: 4.05e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  412 SAKDPDVTNNS-IRYSIDrSSDPGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDN 490
Cdd:smart00112   1 SATDADSGENGkVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1370473424  491 AP 492
Cdd:smart00112  80 AP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 85-163 2.73e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.73e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424   85 SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEFIIKIQDINDNEP 163
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATD-GGGPPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 498-595 1.27e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 78.51  E-value: 1.27e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 498 YEAFVCENAKAGQLIQTVSAVDQDDPRNGQhFYYSLAPEAANNPnFTIrdnQDNTARILTRRSGFRQQeQSVFHLPILIA 577
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGE-VTYSIVSGNEDGL-FSI---DPSTGEITTAKPLDREE-QSSYTLTVTAT 75

                          90
                  ....*....|....*...
gi 1370473424 578 DSGQPVLSSTGTLTIQVC 595
Cdd:cd11304    76 DGGGPPLSSTATVTITVL 93
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 80-161 3.74e-17

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 77.35  E-value: 3.74e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  80 VGKLH-SDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDRRtGRPMEPESEFIIKIQD 157
Cdd:cd11304    16 VLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGG-GPPLSSTATVTITVLD 94


                  ....
gi 1370473424 158 INDN 161
Cdd:cd11304    95 VNDN 98
Cadherin pfam00028
Cadherin domain;
498-595 4.44e-15

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 71.18  E-value: 4.44e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 498 YEAFVCENAKAGQLIQTVSAVDQDDPRNGQHFYYSLAPEAANnpNFTI-RDNQD-NTARILTRrsgfrqQEQSVFHLPIL 575
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGG--NFRIdPDTGDiSTTKPLDR------ESIGEYELTVE 72

                          90       100
                  ....*....|....*....|
gi 1370473424 576 IADSGQPVLSSTGTLTIQVC 595
Cdd:pfam00028  73 ATDSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 298-387 8.21e-15

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 70.07  E-value: 8.21e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  298 AKDLDEGINAEMKYTIVDGDGADAFDISTDPnfqvGIITVKKPLSFESKKSYTLKVE---GANPhlemrflnlgPFQDTT 374
Cdd:smart00112   2 ATDADSGENGKVTYSILSGNDDGLFSIDPET----GEITTTKPLDREEQPEYTLTVEatdGGGP----------PLSSTA 67

                           90
                   ....*....|....
gi 1370473424  375 TVHISVEDV-DEPP 387
Cdd:smart00112  68 TVTITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
279-381 2.11e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.11e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424 279 YQMSVLESAPISSTVGRVFAKDLDEGINAEMKYTIVDGDGADAFDISTDPnfqvGIITVKKPLSFESKKSYTLKVEGANp 358
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRIDPDT----GDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|...
gi 1370473424 359 hlemrfLNLGPFQDTTTVHISVE 381
Cdd:pfam00028  76 ------SGGPPLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
73-156 2.30e-10

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 57.70  E-value: 2.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  73 TGTDPLYVGKlhSDMDRGD-GSIKYILSGEGAGIVFTIDDTTGDIHAIQRLDREERAQYTLRAQALDrRTGRPMEPESEF 151
Cdd:pfam00028  11 VGTEVLTVTA--TDPDLGPnGRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATV 87


                  ....*
gi 1370473424 152 IIKIQ 156
Cdd:pfam00028  88 TITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 516-599 4.44e-10

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 56.59  E-value: 4.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  516 SAVDQDDPRNGQhFYYSLAPEAANNPnFTIRDNQDntarILTRRSGFRQQEQSVFHLPILIADSGQPVLSSTGTLTIQVC 595
Cdd:smart00112   1 SATDADSGENGK-VTYSILSGNDDGL-FSIDPETG----EITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74


                   ....
gi 1370473424  596 SCDD 599
Cdd:smart00112  75 DVND 78
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 68-161 4.61e-05

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 43.10  E-value: 4.61e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370473424  68 VLEEYTGtdPLYVGKLHSDMDRGDGSIkYILSGEGAGI---VFTIDDTTGDIHAIQRLDREERAQYTLRAQALdRRTGRP 144
Cdd:cd00031     6 AVEGRSR--GSFRVSIPTDLIASSGEI-IKISAAGKEAlpsWLHWEPHSGILEGLEKLDREDKGVHYISVSAA-SLGANV 81

                          90
                  ....*....|....*..
gi 1370473424 145 MEPESEFIIKIQDINDN 161
Cdd:cd00031    82 PQTSSVFSIEVYDENDN 98
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 433-490 1.38e-03

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 38.86  E-value: 1.38e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370473424 433 PGRFFYVDITTGALMTARPLDREEFSWHNITVLAMEMNNPSQVGSVPVTIKVLDVNDN 490
Cdd:cd00031    41 LPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTSSVFSIEVYDENDN 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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