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Conserved domains on  [gi|1370474413|ref|XP_024307132|]
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uncharacterized protein C19orf47 isoform X6 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF5577 super family cl39267
Family of unknown function (DUF5577); This is a family of unknown function found in Metazoa.
 93-344 1.54e-89

Family of unknown function (DUF5577); This is a family of unknown function found in Metazoa.


The actual alignment was detected with superfamily member pfam17740:

Pssm-ID: 407613  Cd Length: 334  Bit Score: 271.84  E-value: 1.54e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413  93 GEIRRG-TSAASRMITNSLNHDSPPSTPPRRPDTSTSKISVTVSNKMAAKSAKATAALaRREEESLAVPA-KRRRVTAEM 170
Cdd:pfam17740   1 AELRRGaNSAASRMIANALNHDSPPHTPARRPDNSTSKISVTVSNKMAAKSAKAAALA-HPAEEGLSLPAaKHRRVTAEM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413 171 EGKYVINMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTT-TGSKPTGVFSRLGATPETDEDLAWDSDNDSSS 249
Cdd:pfam17740  80 EGKYIIHMPKGSTPRTRKILAQQQAAKGLHRTSVFARLGAESKADTTtSGNKPTGVFSRLGAGDEEDDDLAPDKMSTCID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413 250 S------------VLQYAGVLKKLGRGP-AKASPQPALTVKAKATSSATTAAA-PTLRRLALSSR---------SGLERK 306
Cdd:pfam17740 160 VddeeddddgegsVLQYAGVLKGAGRFPkKEAAAKPALTVKAKATSSATTTATpPKLRRLAGKFKlppsdtttsSGLEKK 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1370474413 307 PESLS--KVSIIKRLGAAALVP---------EAQDSQVTSTKSTNKTAV 344
Cdd:pfam17740 240 PDGLPlaKVSILKRLGKAAATHpsavspapaDAQDNQVTSTKPKAQAEL 288
SAM_4 pfam18017
SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the ...
 1-84 6.69e-58

SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the N-terminus of the human C19orf47 protein.


:

Pssm-ID: 407856 [Multi-domain]  Cd Length: 84  Bit Score: 181.81  E-value: 6.69e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413   1 MVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAA 80
Cdd:pfam18017   1 MASVTMATSEWIQFFKDAGIPAGLAVNYAVMFVDNRIQKNMLLDLNKDIMMDLGITVIGDIIAILKHAKQVHRQDMCKAA 80


                  ....
gi 1370474413  81 TESV 84
Cdd:pfam18017  81 TEAI 84
 
Name Accession Description Interval E-value
DUF5577 pfam17740
Family of unknown function (DUF5577); This is a family of unknown function found in Metazoa.
 93-344 1.54e-89

Family of unknown function (DUF5577); This is a family of unknown function found in Metazoa.


Pssm-ID: 407613  Cd Length: 334  Bit Score: 271.84  E-value: 1.54e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413  93 GEIRRG-TSAASRMITNSLNHDSPPSTPPRRPDTSTSKISVTVSNKMAAKSAKATAALaRREEESLAVPA-KRRRVTAEM 170
Cdd:pfam17740   1 AELRRGaNSAASRMIANALNHDSPPHTPARRPDNSTSKISVTVSNKMAAKSAKAAALA-HPAEEGLSLPAaKHRRVTAEM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413 171 EGKYVINMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTT-TGSKPTGVFSRLGATPETDEDLAWDSDNDSSS 249
Cdd:pfam17740  80 EGKYIIHMPKGSTPRTRKILAQQQAAKGLHRTSVFARLGAESKADTTtSGNKPTGVFSRLGAGDEEDDDLAPDKMSTCID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413 250 S------------VLQYAGVLKKLGRGP-AKASPQPALTVKAKATSSATTAAA-PTLRRLALSSR---------SGLERK 306
Cdd:pfam17740 160 VddeeddddgegsVLQYAGVLKGAGRFPkKEAAAKPALTVKAKATSSATTTATpPKLRRLAGKFKlppsdtttsSGLEKK 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1370474413 307 PESLS--KVSIIKRLGAAALVP---------EAQDSQVTSTKSTNKTAV 344
Cdd:pfam17740 240 PDGLPlaKVSILKRLGKAAATHpsavspapaDAQDNQVTSTKPKAQAEL 288
SAM_4 pfam18017
SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the ...
 1-84 6.69e-58

SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the N-terminus of the human C19orf47 protein.


Pssm-ID: 407856 [Multi-domain]  Cd Length: 84  Bit Score: 181.81  E-value: 6.69e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413   1 MVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAA 80
Cdd:pfam18017   1 MASVTMATSEWIQFFKDAGIPAGLAVNYAVMFVDNRIQKNMLLDLNKDIMMDLGITVIGDIIAILKHAKQVHRQDMCKAA 80


                  ....
gi 1370474413  81 TESV 84
Cdd:pfam18017  81 TEAI 84
SAM_CS047 cd09531
SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a ...
 8-72 5.06e-42

SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a putative protein-protein interaction domain. Proteins of this subfamily have a SAM domain at the N-terminus. SAM is a widespread domain in signaling and regulatory proteins. In many cases SAM mediates homodimerization/oligomerization. The exact function of proteins belonging to this group is unknown.


Pssm-ID: 188930 [Multi-domain]  Cd Length: 65  Bit Score: 140.51  E-value: 5.06e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370474413   8 TSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVH 72
Cdd:cd09531     1 TSEWIKFFKDAGIPSGLAAKYAVIFVENRIQKEMLLDLNKEILKEMGITVMGDIIAILKHAKKVH 65
 
Name Accession Description Interval E-value
DUF5577 pfam17740
Family of unknown function (DUF5577); This is a family of unknown function found in Metazoa.
 93-344 1.54e-89

Family of unknown function (DUF5577); This is a family of unknown function found in Metazoa.


Pssm-ID: 407613  Cd Length: 334  Bit Score: 271.84  E-value: 1.54e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413  93 GEIRRG-TSAASRMITNSLNHDSPPSTPPRRPDTSTSKISVTVSNKMAAKSAKATAALaRREEESLAVPA-KRRRVTAEM 170
Cdd:pfam17740   1 AELRRGaNSAASRMIANALNHDSPPHTPARRPDNSTSKISVTVSNKMAAKSAKAAALA-HPAEEGLSLPAaKHRRVTAEM 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413 171 EGKYVINMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTT-TGSKPTGVFSRLGATPETDEDLAWDSDNDSSS 249
Cdd:pfam17740  80 EGKYIIHMPKGSTPRTRKILAQQQAAKGLHRTSVFARLGAESKADTTtSGNKPTGVFSRLGAGDEEDDDLAPDKMSTCID 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413 250 S------------VLQYAGVLKKLGRGP-AKASPQPALTVKAKATSSATTAAA-PTLRRLALSSR---------SGLERK 306
Cdd:pfam17740 160 VddeeddddgegsVLQYAGVLKGAGRFPkKEAAAKPALTVKAKATSSATTTATpPKLRRLAGKFKlppsdtttsSGLEKK 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 1370474413 307 PESLS--KVSIIKRLGAAALVP---------EAQDSQVTSTKSTNKTAV 344
Cdd:pfam17740 240 PDGLPlaKVSILKRLGKAAATHpsavspapaDAQDNQVTSTKPKAQAEL 288
SAM_4 pfam18017
SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the ...
 1-84 6.69e-58

SAM domain (Sterile alpha motif); This entry corresponds to a SAM domain that is found at the N-terminus of the human C19orf47 protein.


Pssm-ID: 407856 [Multi-domain]  Cd Length: 84  Bit Score: 181.81  E-value: 6.69e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413   1 MVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAA 80
Cdd:pfam18017   1 MASVTMATSEWIQFFKDAGIPAGLAVNYAVMFVDNRIQKNMLLDLNKDIMMDLGITVIGDIIAILKHAKQVHRQDMCKAA 80


                  ....
gi 1370474413  81 TESV 84
Cdd:pfam18017  81 TEAI 84
SAM_CS047 cd09531
SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a ...
 8-72 5.06e-42

SAM domain of CS047 subfamily; SAM (sterile alpha motif) domain of CS047 subfamily is a putative protein-protein interaction domain. Proteins of this subfamily have a SAM domain at the N-terminus. SAM is a widespread domain in signaling and regulatory proteins. In many cases SAM mediates homodimerization/oligomerization. The exact function of proteins belonging to this group is unknown.


Pssm-ID: 188930 [Multi-domain]  Cd Length: 65  Bit Score: 140.51  E-value: 5.06e-42
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370474413   8 TSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAKVVH 72
Cdd:cd09531     1 TSEWIKFFKDAGIPSGLAAKYAVIFVENRIQKEMLLDLNKEILKEMGITVMGDIIAILKHAKKVH 65
SAM_superfamily cd09487
SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of ...
 10-69 3.12e-08

SAM (Sterile alpha motif ); SAM (Sterile Alpha Motif) domain is a module consisting of approximately 70 amino acids. This domain is found in the Fungi/Metazoa group and in a restricted number of bacteria. Proteins with SAM domains are represented by a wide variety of domain architectures and have different intracellular localization, including nucleus, cytoplasm and membranes. SAM domains have diverse functions. They can interact with proteins, RNAs and membrane lipids, contain site of phosphorylation and/or kinase docking site, and play a role in protein homo and hetero dimerization/oligomerization in processes ranging from signal transduction to regulation of transcription. Mutations in SAM domains have been linked to several diseases.


Pssm-ID: 188886 [Multi-domain]  Cd Length: 56  Bit Score: 49.55  E-value: 3.12e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370474413  10 EWIQFFKEAGIPPgpavnYAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAK 69
Cdd:cd09487     1 DVAEWLESLGLEQ-----YADLFRKNEIDGDALLLLTDEDLKELGITSPGHRKKILRAIQ 55
SAM_Ste11_fungal cd09534
SAM domain of Ste11_fungal subfamily; SAM (sterile alpha motif) domain of Ste11 subfamily is a ...
 28-69 5.83e-06

SAM domain of Ste11_fungal subfamily; SAM (sterile alpha motif) domain of Ste11 subfamily is a protein-protein interaction domain. Proteins of this subfamily have SAM domain at the N-terminus and protein kinase domain at the C-terminus. They participate in regulation of mating pheromone response, invasive growth and high osmolarity growth response. MAP triple kinase Ste11 from S.cerevisia is known to interact with Ste20 kinase and Ste50 regulator. These kinases are able to form homodimers interacting through their SAM domains as well as heterodimers or heterogenous complexes when either SAM domain of monomeric or homodimeric form of Ste11 interacts with Ste50 regulator.


Pssm-ID: 188933  Cd Length: 62  Bit Score: 43.35  E-value: 5.83e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1370474413  28 YAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILKHAK 69
Cdd:cd09534    18 YLDIFEKNLITGDLLLELDKEALKELGITKVGDRIRLLRAIK 59
SAM_SLA1_fungal cd09532
SAM domain of SLA1 subfamily; SAM (sterile alpha motif) domain of fungal SLA1 proteins is a ...
 10-67 3.87e-05

SAM domain of SLA1 subfamily; SAM (sterile alpha motif) domain of fungal SLA1 proteins is a protein-protein interaction domain. Proteins of this group consist of a few N-terminal SH3 domains followed by SHD1 domain, SAM domain (also known as SHD2) and multiple C-terminal repeats. The yeast SLA1 protein is an endocytic clathrin adaptor. It is associated with a variety of endocytic accessory factors and required for endocytic vesicle formation and for clathrin and actin-dependent cargo recognition. SLA1 binds clathrin through a variant clathrin-binding motif (vCB). The SAM domain negatively regulates this binding by blocking the vCB site. The SAM domains of SLA1 proteins can form oligomers via their mid-loop (ML) and end-helix (EH) regions. Such self-associations apparently are important for SLA1 function. A proposed regulatory model suggests that SAM can be considered a mediator of two aspects of clathrin adaptor function. It plays a role in negative regulation of clathrin binding via an intramolecular interaction with the vCB, and a role in positive regulation of vesicle coat assembly via self-oligomerization.


Pssm-ID: 188931 [Multi-domain]  Cd Length: 62  Bit Score: 40.85  E-value: 3.87e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370474413  10 EWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLDLNKEIMNELGVTvVGDIIAILKH 67
Cdd:cd09532     2 DWFEFFLNCGVDVSLCQRYASNFERDQMDESVLPDINPSTLRTLGLR-EGDIIRVMKF 58
SAM_Shank1,2,3 cd09506
SAM domain of Shank1,2,3 family proteins; SAM (sterile alpha motif) domain of Shank1,2,3 ...
 28-79 1.12e-03

SAM domain of Shank1,2,3 family proteins; SAM (sterile alpha motif) domain of Shank1,2,3 family proteins is a protein-protein interaction domain. Shank1,2,3 proteins are scaffold proteins that are known to interact with a variety of cytoplasmic and membrane proteins. SAM domains of the Shank1,2,3 family are prone to homooligomerization. They are highly enriched in the postsynaptic density, acting as scaffolds to organize assembly of postsynaptic proteins. SAM domains of Shank3 proteins can form large sheets of helical fibers. Shank genes show distinct patterns of expression, in rat Shank1 mRNA is found almost exclusively in brain, Shank2 in brain, kidney and liver, and Shank3 in heart, brain and spleen.


Pssm-ID: 188905  Cd Length: 66  Bit Score: 36.91  E-value: 1.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370474413  28 YAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGdiiailkhakvvHRQDMCKA 79
Cdd:cd09506    22 HRERFMDNEIDGSHLPNLDKEDLTELGVTRVG------------HRMNIERA 61
SAM_Ste50-like_fungal cd09533
SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or ...
 28-66 7.07e-03

SAM domain of Ste50_like (ubc2) subfamily; SAM (sterile alpha motif) domain of Ste50-like (or Ubc2 for Ustilago bypass of cyclase) subfamily is a putative protein-protein interaction domain. This group includes only fungal proteins. Basidiomycetes have an N-terminal SAM domain, central UBQ domain, and C-terminal SH3 domain, while Ascomycetes lack the SH3 domain. Ubc2 of Ustilago maydis is a major virulence and maize pathogenicity factor. It is required for filamentous growth (the budding haploid form of Ustilago maydis is a saprophyte, while filamentous dikaryotic form is a pathogen). Also the Ubc2 protein is involved in the pheromone-responsive morphogenesis via the MAP kinase cascade. The SAM domain is necessary for ubc2 function; deletion of SAM eliminates this function. A Lys-to-Glu mutation in the SAM domain of ubc2 gene induces temperature sensitivity.


Pssm-ID: 188932  Cd Length: 58  Bit Score: 34.60  E-value: 7.07e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1370474413  28 YAVMFVDNRIQKSMLLDLNKEIMNELGVTVVGDIIAILK 66
Cdd:cd09533    14 YEDQFIENGITGDVLVALDHEDLKEMGITSVGHRLTILK 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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