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Conserved domains on  [gi|1370475114|ref|XP_024307275|]
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zinc finger protein 808 isoform X1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217|GO:0003700
PubMed:  8183940|22803940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 3.13e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 3.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370475114  24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-839 4.75e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 4.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 397 KTYKCNECGKAFNHQSSLARHHILHTGEKPYKC--EECDKVFSQKSTLERHKRIHTGEKPYKCkvCDTAFTCNSQLARHR 474
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 475 RIHTGEKTYKCNECRK---TFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASlvYHRRLHTLEKSYKCTVCNKVFMRN 551
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--SNSLHPPLPANSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 552 SvlavHTRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEACDKVFGQKSALESHKRIHTGEKPYRCQVCDTA 631
Cdd:COG5048   188 I----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 632 FTWNSQLARHTRIHTGEKT-------YKCNECGKTFSYKSSLVWHRR--LHGGE--KSYKCKV--CDKAFVCRSYVAKHT 698
Cdd:COG5048   264 SLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 699 RIHSGMKPYKC--NECSKTFS-----NRSSLVCHRRIHSGEKPYKC--SECSKTFSQKATLLCHRRLHSGEKPYKCndcg 769
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC---- 419

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 770 ntfrhwsslvyhrrlhtgeksyKCTVCDKAFVRNSYLARHIRIHTAEKPYkCNECGKAFNEQSHLSRHHR 839
Cdd:COG5048   420 ----------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-585 5.14e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 5.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 206 NNYGNNPLNSSLLPQKQEvhmreKSFPCNESGKAFNCSSL--LRKHQIPHLGDKQYKCDVCGKLFNHKQYLACHRRCHTG 283
Cdd:COG5048    42 SFSRLEHLTRHIRSHTGE-----KPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 284 E-KPYKCKECGKSFSYKSSLTCHHRLHTGVKPYKCNECGKVFRQ----------------------NSALVIHKAIHTGE 340
Cdd:COG5048   117 SnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSNVSTSI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 341 KPYKCNECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSGEKTYKCNECGKAFNHQSSLARHHIL 420
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 421 HTGE-------KPYKCEECDKVFSQKSTLERHKR--IHTGE--KPYKCKV--CDTAFTCNSQLARHRRIHTGEKTYKCNE 487
Cdd:COG5048   277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 488 CRKTFSRRSSL-------LCHRRLHSGEKPYKC--NQCGNTFRHRASLVYHRRLHTLEKS--YKCTVCNKVFMRNSVLAV 556
Cdd:COG5048   357 LNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                         410       420
                  ....*....|....*....|....*....
gi 1370475114 557 HTRIHTAKKPYkCNECGKAFNQQSHLSRH 585
Cdd:COG5048   437 HKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
861-885 9.50e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.50e-04
                          10        20
                  ....*....|....*....|....*
gi 1370475114 861 HLKRHRIIHTGEKPYKCNECGKAFS 885
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
833-858 1.85e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370475114 833 HLSRHHRIHTGEKPYKCEACDKVFSR 858
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 3.13e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 3.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370475114  24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-60 8.45e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 8.45e-17
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1370475114   24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 5.38e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 5.38e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370475114  24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-839 4.75e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 4.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 397 KTYKCNECGKAFNHQSSLARHHILHTGEKPYKC--EECDKVFSQKSTLERHKRIHTGEKPYKCkvCDTAFTCNSQLARHR 474
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 475 RIHTGEKTYKCNECRK---TFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASlvYHRRLHTLEKSYKCTVCNKVFMRN 551
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--SNSLHPPLPANSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 552 SvlavHTRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEACDKVFGQKSALESHKRIHTGEKPYRCQVCDTA 631
Cdd:COG5048   188 I----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 632 FTWNSQLARHTRIHTGEKT-------YKCNECGKTFSYKSSLVWHRR--LHGGE--KSYKCKV--CDKAFVCRSYVAKHT 698
Cdd:COG5048   264 SLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 699 RIHSGMKPYKC--NECSKTFS-----NRSSLVCHRRIHSGEKPYKC--SECSKTFSQKATLLCHRRLHSGEKPYKCndcg 769
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC---- 419

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 770 ntfrhwsslvyhrrlhtgeksyKCTVCDKAFVRNSYLARHIRIHTAEKPYkCNECGKAFNEQSHLSRHHR 839
Cdd:COG5048   420 ----------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-585 5.14e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 5.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 206 NNYGNNPLNSSLLPQKQEvhmreKSFPCNESGKAFNCSSL--LRKHQIPHLGDKQYKCDVCGKLFNHKQYLACHRRCHTG 283
Cdd:COG5048    42 SFSRLEHLTRHIRSHTGE-----KPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 284 E-KPYKCKECGKSFSYKSSLTCHHRLHTGVKPYKCNECGKVFRQ----------------------NSALVIHKAIHTGE 340
Cdd:COG5048   117 SnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSNVSTSI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 341 KPYKCNECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSGEKTYKCNECGKAFNHQSSLARHHIL 420
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 421 HTGE-------KPYKCEECDKVFSQKSTLERHKR--IHTGE--KPYKCKV--CDTAFTCNSQLARHRRIHTGEKTYKCNE 487
Cdd:COG5048   277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 488 CRKTFSRRSSL-------LCHRRLHSGEKPYKC--NQCGNTFRHRASLVYHRRLHTLEKS--YKCTVCNKVFMRNSVLAV 556
Cdd:COG5048   357 LNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                         410       420
                  ....*....|....*....|....*....
gi 1370475114 557 HTRIHTAKKPYkCNECGKAFNQQSHLSRH 585
Cdd:COG5048   437 HKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
861-885 9.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.50e-04
                          10        20
                  ....*....|....*....|....*
gi 1370475114 861 HLKRHRIIHTGEKPYKCNECGKAFS 885
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
833-858 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370475114 833 HLSRHHRIHTGEKPYKCEACDKVFSR 858
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
805-829 1.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475114 805 YLARHIRIHTAEKPYKCNECGKAFN 829
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370475114 357 HLSRHQRLHTGVKPYKCKICEKAFAC 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 816-893 3.34e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 816 EKPYKCN--ECGKAFNEQSHLsRHHRIHTGEKPYKCEACDKVfsrkshlkRHRIIHTGEKPYKCNECGKAFSDRSTLIHH 893
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 24-60 3.13e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 78.67  E-value: 3.13e-18
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370475114  24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNL 38
KRAB smart00349
krueppel associated box;
24-60 8.45e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.32  E-value: 8.45e-17
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1370475114   24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 24-60 5.38e-15

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 69.50  E-value: 5.38e-15
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1370475114  24 LTFRDVAIEFSLAEWKFLNPAQRALYREVMLENYRNL 60
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
397-839 4.75e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.42  E-value: 4.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 397 KTYKCNECGKAFNHQSSLARHHILHTGEKPYKC--EECDKVFSQKSTLERHKRIHTGEKPYKCkvCDTAFTCNSQLARHR 474
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 475 RIHTGEKTYKCNECRK---TFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASlvYHRRLHTLEKSYKCTVCNKVFMRN 551
Cdd:COG5048   110 LSSSSSNSNDNNLLSShslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQ--SNSLHPPLPANSLSKDPSSNLSLL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 552 SvlavHTRIHTAKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEACDKVFGQKSALESHKRIHTGEKPYRCQVCDTA 631
Cdd:COG5048   188 I----SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 632 FTWNSQLARHTRIHTGEKT-------YKCNECGKTFSYKSSLVWHRR--LHGGE--KSYKCKV--CDKAFVCRSYVAKHT 698
Cdd:COG5048   264 SLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHI 343

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 699 RIHSGMKPYKC--NECSKTFS-----NRSSLVCHRRIHSGEKPYKC--SECSKTFSQKATLLCHRRLHSGEKPYKCndcg 769
Cdd:COG5048   344 LLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNC---- 419

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 770 ntfrhwsslvyhrrlhtgeksyKCTVCDKAFVRNSYLARHIRIHTAEKPYkCNECGKAFNEQSHLSRHHR 839
Cdd:COG5048   420 ----------------------KNPPCSKSFNRHYNLIPHKKIHTNHAPL-LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
313-725 1.73e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.41  E-value: 1.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 313 KPYKCNECGKVFRQNSALVIHKAIHTGEKPYKCN--ECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKafACHSYLANHT 390
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP--LSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 391 RIHSGEKTYKCN-ECGKAFNHQSSLARHHILHTGEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKvcdtAFTCNSQ 469
Cdd:COG5048   110 LSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSK----DPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 470 LARHRRIHTGEKTYKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASLVYHRRL-HTLEKSYKCTVCNKVF 548
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 549 -MRNSVLAVHTRIHTAK-----KPYKCNECGKAFNQQSHLSRHRR--LHTGE--KPYKC--EACDKVFGQKSALESHKRI 616
Cdd:COG5048   266 pTASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 617 HTGEKPYRC--QVCDTAFT-----WNSQLARHTRIHTGEKTYKC--NECGKTFSYKSSLVWHRRLH--GGEKSYKCKVCD 685
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHlsFRPYNCKNPPCS 425

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1370475114 686 KAFVcRSYVAKHTRIHSGMKPYKCNECSKTFSNRSSLVCH 725
Cdd:COG5048   426 KSFN-RHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
341-746 6.58e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 6.58e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 341 KPYKCNECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKAFACHSYLANHT---RIHSGEKTYKCNECGKAFNHQSSLARH 417
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRhlrTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 418 HILHTGEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKVCDTAFTCNSQLARHRRIHTGektykcNECRKTFSRRSS 497
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA------NSLSKDPSSNLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 498 LLCHRRLHSGEKPYKCNQCGNTFRHRASLVYHRRLHTLEKSYKCTVCNKVFMRNSVLA------VHTRIHTAKKPYKCNE 571
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 572 CGKAFNQQSHLSRHRRLHTG-EKPYKCEACDKVFGQKSALESHKR--IHTGE--KPYRC--QVCDTAFTWNSQLARHTRI 644
Cdd:COG5048   266 PTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 645 HTGEKTYKCNECGKTFSYKSSL----VWHRRLHGGEKSYKCKVCD-----KAFVCRSYVAKHTRIHSGMKP--YKCNECS 713
Cdd:COG5048   346 HTSISPAKEKLLNSSSKFSPLLnnepPQSLQQYKDLKNDKKSETLsnsciRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1370475114 714 KTFSNRSSLVCHRRIHSGEKPYKCSECSKTFSQ 746
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
563-897 4.43e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.18  E-value: 4.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 563 AKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEA--CDKVFGQKSALESHKRIHTGEKPYRC-QVCDTAFTWNSQLA 639
Cdd:COG5048    30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 640 RHTRIHTGEKTYKCNECGKTFSYKSSLVWHRRLHGGEKSYKCKVCDKAFVCRSYVAKHTRIHSGMkpykcNECSKTFSNR 719
Cdd:COG5048   110 LSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 720 SSLVCHRRIHSGEKPYKCSECSKTFSQKATLLcHRRLHSGEKPYKCNDCGNTFRHwsSLVYHRRLHTGeKSYKCTVCDKA 799
Cdd:COG5048   185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSS-DQNLENSSSSLPLTTNSQLSPK--SLLSQSPSSLS-SSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 800 FVRNSYLARHIRIHTAE----------KPYKCNECGKAFNEQSHLSRH--HRIHTGE--KPYKC--EACDKVFSRKSHLK 863
Cdd:COG5048   261 PRSSLPTASSQSSSPNEsdsssekgfsLPIKSKQCNISFSRSSPLTRHlrSVNHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350
                  ....*....|....*....|....*....|....*.
gi 1370475114 864 RHRIIHTGEKPYKC--NECGKAFSDRSTLIHHQAIH 897
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ 376
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
256-626 1.40e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 1.40e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 256 DKQYKCDVCGKLFNHKQYLACHRRCHTGEKPYKC--KECGKSFSYKSSLTCHHRLHTGVKPYKCNecGKVFRQNSALVIH 333
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS--KSLPLSNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 334 KAIHTGEKPYKCNECgkAFNQQSHLSRHQRLHTGVKPYKcKICEKAFACHSYLAN------------------------- 388
Cdd:COG5048   109 SLSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISN-LRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssnls 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 389 ---HTRIHSGEKTYKCNECGKAFNHQSSLARHHILHTGEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKVCDTAFT 465
Cdd:COG5048   186 lliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 466 CNSQLARHRRIHTGEKT-------YKCNECRKTFSRRSSLLCHRR--LHSGE--KPYKC--NQCGNTFRHRASLVYHRRL 532
Cdd:COG5048   266 PTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 533 HTLEKSYKC--TVCNKVFMRNSV-----LAVHTRIHTAKKPYKC--NECGKAFNQQSHLSRHRRLHTGEKP--YKCEACD 601
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCS 425

                         410       420
                  ....*....|....*....|....*
gi 1370475114 602 KVFGQKSALESHKRIHTGEKPYRCQ 626
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCS 450
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
206-585 5.14e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 5.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 206 NNYGNNPLNSSLLPQKQEvhmreKSFPCNESGKAFNCSSL--LRKHQIPHLGDKQYKCDVCGKLFNHKQYLACHRRCHTG 283
Cdd:COG5048    42 SFSRLEHLTRHIRSHTGE-----KPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSN 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 284 E-KPYKCKECGKSFSYKSSLTCHHRLHTGVKPYKCNECGKVFRQ----------------------NSALVIHKAIHTGE 340
Cdd:COG5048   117 SnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtpqsnslhpplpanslskdpssNLSLLISSNVSTSI 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 341 KPYKCNECGKAFNQQSHLSRHQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSGEKTYKCNECGKAFNHQSSLARHHIL 420
Cdd:COG5048   197 PSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPN 276

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 421 HTGE-------KPYKCEECDKVFSQKSTLERHKR--IHTGE--KPYKCKV--CDTAFTCNSQLARHRRIHTGEKTYKCNE 487
Cdd:COG5048   277 ESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKL 356

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 488 CRKTFSRRSSL-------LCHRRLHSGEKPYKC--NQCGNTFRHRASLVYHRRLHTLEKS--YKCTVCNKVFMRNSVLAV 556
Cdd:COG5048   357 LNSSSKFSPLLnneppqsLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIP 436

                         410       420
                  ....*....|....*....|....*....
gi 1370475114 557 HTRIHTAKKPYkCNECGKAFNQQSHLSRH 585
Cdd:COG5048   437 HKKIHTNHAPL-LCSILKSFRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
481-897 6.39e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 6.39e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 481 KTYKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQ--CGNTFRHRASLVYHRRLHTLEKSYKCtvCNKVFMRNSVLAVHT 558
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSSS 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 559 RIHTAKKPYKCNECgkAFNQQSHLSRHRRLHTGEKPYKCEACDKvfgQKSALESHKRIHTGEKPYRCQVCDTAFTWNSQL 638
Cdd:COG5048   110 LSSSSSNSNDNNLL--SSHSLPPSSRDPQLPDLLSISNLRNNPL---PGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNL 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 639 AR--HTRIHTGEKTYKCNECGKTFSYKSSLVWHRRLHGGEKSYKCKVCDKAFVCRSYVAKHTrihSGMKPYKCNECSKTF 716
Cdd:COG5048   185 SLliSSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPS---SLSSSDSSSSASESP 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 717 -SNRSSLVCHRRIHSgekpYKCSECSKTFSqkatllchrrlhsgeKPYKCNDCGNTFRHWSSLVYHRR--LHTGE--KSY 791
Cdd:COG5048   262 rSSLPTASSQSSSPN----ESDSSSEKGFS---------------LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPF 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 792 KCTV--CDKAFVRNSYLARHIRIHTAEKPYKCNEC------GKAFNEQSHLSRHHRIHTGEKPYKCEA---CDKVFSRKS 860
Cdd:COG5048   323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfSPLLNNEPPQSLQQYKDLKNDKKSETLsnsCIRNFKRDS 402

                         410       420       430
                  ....*....|....*....|....*....|....*....
gi 1370475114 861 HLKRHRIIHTGEKPY--KCNECGKAFSDRSTLIHHQAIH 897
Cdd:COG5048   403 NLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIH 441
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
104-419 4.74e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 4.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 104 QEIEKEIHNIEFQCQEDERNGHEAPTTK-IKKLTGSTDQHDHRHAGNKPIKDQLGSSFYSHLP-----ELHIFQIKGEIA 177
Cdd:COG5048   135 PQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPsssenSPLSSSYSIPSS 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 178 NQLEKSTSDASSVSTSQRiSCRPQIHISNNYGNNPLNSSLLPQKQEVHMREKSFPcNESGKAFNCSSLLrKHQIPhlgDK 257
Cdd:COG5048   215 SSDQNLENSSSSLPLTTN-SQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA-SSQSSSPNESDSS-SEKGF---SL 288

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 258 QYKCDVCGKLFNHKQYLACHRRC--HTGE--KPYKCKE--CGKSFSYKSSLTCHHRLHTGVKPYKC--NECGKVFRQNS- 328
Cdd:COG5048   289 PIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLn 368

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 329 ----ALVIHKAIHTGEKPYKC--NECGKAFNQQSHLSRHQRLHTGVKP--YKCKICEKAFACHSYLANHTRIHSgEKTYK 400
Cdd:COG5048   369 neppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAPL 447

                         330
                  ....*....|....*....
gi 1370475114 401 CNECGKAFNHQSSLARHHI 419
Cdd:COG5048   448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 782-866 5.31e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 5.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 782 RRLHT-GEKSYKCTV--CDKAFVRNSYLARHiRIHtaekpykcNECGKAFNEQSHLSRHHRIHTGEKPYKCEACDKVFSR 858
Cdd:COG5189   340 RMLKVkDGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKN 410


                  ....*...
gi 1370475114 859 KSHLKRHR 866
Cdd:COG5189   411 LNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
861-885 9.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 9.50e-04
                          10        20
                  ....*....|....*....|....*
gi 1370475114 861 HLKRHRIIHTGEKPYKCNECGKAFS 885
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 565-641 1.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.72e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370475114 565 KPYKCN--ECGKAFNQQSHLSRHRrLHTGEKPYKCEACDKvfgqksalESHKRIHTGEKPYRCQVCDTAFTWNSQLARH 641
Cdd:COG5189   348 KPYKCPveGCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 395-474 1.75e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 395 GEKTYKCN--ECGKAFNHQSSLaRHHILHTGEKPYKCEECDKvfsqkstlERHKRIHTGEKPYKCKVCDTAFTCNSQLAR 472
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1370475114 473 HR 474
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
833-858 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370475114 833 HLSRHHRIHTGEKPYKCEACDKVFSR 858
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 451-535 1.87e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 451 GEKPYKCKV--CDTAFTCNSQLARHRrihtgektyKCNECRKTFSRRSSLLCHRRLHSGEKPYKCNQCGNTFRHRASLVY 528
Cdd:COG5189   346 DGKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*..
gi 1370475114 529 HRRLHTL 535
Cdd:COG5189   417 HRKHSHD 423
zf-H2C2_2 pfam13465
Zinc-finger double domain;
805-829 1.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.89e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475114 805 YLARHIRIHTAEKPYKCNECGKAFN 829
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
357-382 3.34e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 3.34e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370475114 357 HLSRHQRLHTGVKPYKCKICEKAFAC 382
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 816-893 3.34e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 816 EKPYKCN--ECGKAFNEQSHLsRHHRIHTGEKPYKCEACDKVfsrkshlkRHRIIHTGEKPYKCNECGKAFSDRSTLIHH 893
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGL-KYHMLHGHQNQKLHENPSPE--------KMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
442-466 3.95e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.95e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475114 442 LERHKRIHTGEKPYKCKVCDTAFTC 466
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
638-662 4.53e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.53e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475114 638 LARHTRIHTGEKTYKCNECGKTFSY 662
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 703-782 4.68e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 703 GMKPYKCN--ECSKTFSNRSSLVCHRrihsgekpyKCSECSKTFSQKATLLCHRRLHSGEKPYKCNDCGNTFRHWSSLVY 780
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ..
gi 1370475114 781 HR 782
Cdd:COG5189   417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
329-354 5.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 1370475114 329 ALVIHKAIHTGEKPYKCNECGKAFNQ 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 283-361 5.71e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 5.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370475114 283 GEKPYKCKECGKSFSYKSSLTC-HHRLHtgvkpykcNECGKVFRQNSALVIHKAIHTGEKPYKCNECGKAFNQQSHLSRH 361
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLkYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
581-604 7.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.55e-03
                          10        20
                  ....*....|....*....|....
gi 1370475114 581 HLSRHRRLHTGEKPYKCEACDKVF 604
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
277-298 9.28e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 9.28e-03
                          10        20
                  ....*....|....*....|..
gi 1370475114 277 HRRCHTGEKPYKCKECGKSFSY 298
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
470-494 9.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.65e-03
                          10        20
                  ....*....|....*....|....*
gi 1370475114 470 LARHRRIHTGEKTYKCNECRKTFSR 494
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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