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Conserved domains on  [gi|1373958744|ref|XP_024356822|]
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uncharacterized protein LOC112272879 isoform X1 [Physcomitrium patens]

Protein Classification

heavy-metal-associated domain-containing protein( domain architecture ID 10449815)

heavy-metal-associated domain-containing protein may function as a heavy metal transporter and/or detoxification protein; such as heavy metal-associated isoprenylated plant proteins

Gene Ontology:  GO:0046872
PubMed:  12443926|8905098

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HMA pfam00403
Heavy-metal-associated domain;
44-94 6.29e-05

Heavy-metal-associated domain;


:

Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 39.52  E-value: 6.29e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1373958744  44 MCCMKCEEKVLEEIREVHGVFDVKVDRMNSKVVVVALPPPNILDE-HEVLRK 94
Cdd:pfam00403   7 MHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLEKlVEAIEK 58
 
Name Accession Description Interval E-value
HMA pfam00403
Heavy-metal-associated domain;
44-94 6.29e-05

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 39.52  E-value: 6.29e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1373958744  44 MCCMKCEEKVLEEIREVHGVFDVKVDRMNSKVVVVALPPPNILDE-HEVLRK 94
Cdd:pfam00403   7 MHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLEKlVEAIEK 58
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
37-77 7.88e-05

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 39.50  E-value: 7.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1373958744  37 KYQLKVK-MCCMKCEEKVLEEIREVHGVFDVKVDRMNSKVVV 77
Cdd:COG2608     3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATV 44
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 39-97 7.67e-04

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 36.43  E-value: 7.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373958744  39 QLKVK-MCCMKCEEKVLEEIREVHGVFDVKVDRMNSKVVVVALPPPNILDEHEVLRKAKK 97
Cdd:cd00371     1 ELSVEgMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDPEVSPEELLEAIEDAGY 60
 
Name Accession Description Interval E-value
HMA pfam00403
Heavy-metal-associated domain;
44-94 6.29e-05

Heavy-metal-associated domain;


Pssm-ID: 459804 [Multi-domain]  Cd Length: 58  Bit Score: 39.52  E-value: 6.29e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1373958744  44 MCCMKCEEKVLEEIREVHGVFDVKVDRMNSKVVVVALPPPNILDE-HEVLRK 94
Cdd:pfam00403   7 MHCGGCAAKVEKALSELPGVLSVSVDLATKTVTVTGDAESTKLEKlVEAIEK 58
CopZ COG2608
Copper chaperone CopZ [Inorganic ion transport and metabolism];
37-77 7.88e-05

Copper chaperone CopZ [Inorganic ion transport and metabolism];


Pssm-ID: 442020 [Multi-domain]  Cd Length: 71  Bit Score: 39.50  E-value: 7.88e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1373958744  37 KYQLKVK-MCCMKCEEKVLEEIREVHGVFDVKVDRMNSKVVV 77
Cdd:COG2608     3 TVTLKVEgMTCGHCVARVEKALKALDGVASVEVDLATGTATV 44
HMA cd00371
Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid ...
 39-97 7.67e-04

Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain contains two cysteine residues that are important in binding and transfer of metal ions, such as copper, cadmium, cobalt and zinc. In the case of copper, stoichiometry of binding is one Cu+ ion per binding domain. Repeats of the HMA domain in copper chaperone has been associated with Menkes/Wilson disease due to binding of multiple copper ions.


Pssm-ID: 238219 [Multi-domain]  Cd Length: 63  Bit Score: 36.43  E-value: 7.67e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1373958744  39 QLKVK-MCCMKCEEKVLEEIREVHGVFDVKVDRMNSKVVVVALPPPNILDEHEVLRKAKK 97
Cdd:cd00371     1 ELSVEgMTCAGCVSKIEKALEKLPGVESVEVDLETGKATVEYDPEVSPEELLEAIEDAGY 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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