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Conserved domains on  [gi|1387231811|ref|XP_024837159|]
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slit homolog 3 protein isoform X1 [Bos taurus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1188-1314 5.49e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 121.37  E-value: 5.49e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811 1188 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKL 1265
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1387231811 1266 QKQPAVSINSPLYLGGIPTSTGLSALRQGMdrplgGFHGCIHEVRINNE 1314
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRA-----GFVGCIRDVRVNGE 126
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-217 1.14e-26

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 1.14e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   62 NAERLDLDRNNITRITKtDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLfqSNLK-LTRLDL 140
Cdd:COG4886    114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL--GNLTnLKELDL 189

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1387231811  141 SENQILGIPrKAFRGIADVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 217
Cdd:COG4886    190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-900 3.05e-23

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 3.05e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  535 TDLRLNDNEISVLEATGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQletahgrAFRGLSGLKTLMLRS 614
Cdd:COG4886     50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  615 NLISCVSNDtFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 694
Cdd:COG4886    123 NQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ------------------------------ 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  695 fLKEIPiqdvaiqdftcdgndesscqlgprcpeqctcvetvvrcsnRGLRALPKgipkdVTELYLEGNHLTAVPKELSSF 774
Cdd:COG4886    171 -LTDLP----------------------------------------EELGNLTN-----LKELDLSNNQITDLPEPLGNL 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  775 RHLTLIDLSNNSIGMLTNyTFSNMSHLSTLILSYNRLRCIPvhSFNGLRSLRVLTLHGNDISSVPEGSfnDLTSLSHLAL 854
Cdd:COG4886    205 TNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDL 279

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1387231811  855 GTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 900
Cdd:COG4886    280 SNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-459 2.90e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 2.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  290 IVDCRGKGLTEIPANLPE--GIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKI 367
Cdd:COG4886    117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  368 TEIPKGLFDglvslqllLLNANKINClrvntfqdlqslsllslYDNKLQTISKGLfAPLQAIQTLHLAQN-----PFVCD 442
Cdd:COG4886    195 TDLPEPLGN--------LTNLEELDL-----------------SGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGN 248

                          170
                   ....*....|....*...
gi 1387231811  443 C-HLRWLadYLQDNPIET 459
Cdd:COG4886    249 LtNLEEL--DLSNNQLTD 264
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1074-1110 1.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387231811 1074 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFSGLHCE 1110
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 998-1031 4.44e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.44e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387231811  998 DDCED-NDCENNATCVDGVNNYVCVCPPNYTGELC 1031
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1035-1072 4.71e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.71e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387231811 1035 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYSGKLCE 1072
Cdd:cd00054      2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-250 1.89e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 1.89e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387231811  188 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVGP-FTLCMAPVHLRG 250
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQPeAALCAGPGALAG 67
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 962-994 3.52e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.52e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1387231811  962 NPCLHGGTCHLSEthkGGFSCSCPLGFEGQRCE 994
Cdd:cd00054      9 NPCQNGGTCVNTV---GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1123-1153 3.61e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.61e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1387231811 1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1153
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 7.95e-05

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.95e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1387231811    33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 725-751 7.99e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


:

Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.07  E-value: 7.99e-05
                           10        20
                   ....*....|....*....|....*..
gi 1387231811  725 CPEQCTCVETVVRCSNRGLRALPKGIP 751
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
505-535 1.02e-03

Leucine rich repeat N-terminal domain;


:

Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 1.02e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1387231811   505 CPDRCRCEGTIVDCSNQKLARIPSHLPEYVT 535
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 1466-1519 4.43e-03

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 37.77  E-value: 4.43e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1387231811  1466 SCATASKIPVMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEELERHLECGC 1519
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGC 77
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 918-953 5.58e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387231811  918 DPCLS-SPCKNNGTCsQDPVEGHRCACSHGYKGRDCT 953
Cdd:cd00054      3 DECASgNPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1188-1314 5.49e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 121.37  E-value: 5.49e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811 1188 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKL 1265
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1387231811 1266 QKQPAVSINSPLYLGGIPTSTGLSALRQGMdrplgGFHGCIHEVRINNE 1314
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRA-----GFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1159-1312 4.15e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 119.83  E-value: 4.15e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811 1159 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1234
Cdd:cd00110      1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1387231811 1235 DGQFHSVELVMLNQTLNLVVDKGAPKSLGKLQKQPAVSINSPLYLGGIPTStglsaLRQGMDRPLGGFHGCIHEVRIN 1312
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPED-----LKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1181-1314 5.00e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.98  E-value: 5.00e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  1181 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKG 1257
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387231811  1258 APKSLGKLQKQPAVSINSPLYLGGIPTSTGLSALRQGmdrplGGFHGCIHEVRINNE 1314
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNGK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-217 1.14e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 1.14e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   62 NAERLDLDRNNITRITKtDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLfqSNLK-LTRLDL 140
Cdd:COG4886    114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL--GNLTnLKELDL 189

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1387231811  141 SENQILGIPrKAFRGIADVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 217
Cdd:COG4886    190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-900 3.05e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 3.05e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  535 TDLRLNDNEISVLEATGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQletahgrAFRGLSGLKTLMLRS 614
Cdd:COG4886     50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  615 NLISCVSNDtFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 694
Cdd:COG4886    123 NQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ------------------------------ 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  695 fLKEIPiqdvaiqdftcdgndesscqlgprcpeqctcvetvvrcsnRGLRALPKgipkdVTELYLEGNHLTAVPKELSSF 774
Cdd:COG4886    171 -LTDLP----------------------------------------EELGNLTN-----LKELDLSNNQITDLPEPLGNL 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  775 RHLTLIDLSNNSIGMLTNyTFSNMSHLSTLILSYNRLRCIPvhSFNGLRSLRVLTLHGNDISSVPEGSfnDLTSLSHLAL 854
Cdd:COG4886    205 TNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDL 279

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1387231811  855 GTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 900
Cdd:COG4886    280 SNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-459 2.90e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 2.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  290 IVDCRGKGLTEIPANLPE--GIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKI 367
Cdd:COG4886    117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  368 TEIPKGLFDglvslqllLLNANKINClrvntfqdlqslsllslYDNKLQTISKGLfAPLQAIQTLHLAQN-----PFVCD 442
Cdd:COG4886    195 TDLPEPLGN--------LTNLEELDL-----------------SGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGN 248

                          170
                   ....*....|....*...
gi 1387231811  443 C-HLRWLadYLQDNPIET 459
Cdd:COG4886    249 LtNLEEL--DLSNNQLTD 264
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-217 9.70e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 9.70e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   61 RNAERLDLDRNNITRITktDFAGLKNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKLQVLPELLFQSNL------K 134
Cdd:cd21340     46 TNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnS 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  135 LTRLDLSenqilgiprkafrgiadvknlqldNNHISCIEDgaFRALRDLEILTLNNNNISRI--LVTSFNHMPKIRTLRL 212
Cdd:cd21340    122 LRVLNIS------------------------GNNIDSLEP--LAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDL 175


                   ....*
gi 1387231811  213 HSNHL 217
Cdd:cd21340    176 TGNPV 180
LRR_8 pfam13855
Leucine rich repeat;
775-835 2.28e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.09  E-value: 2.28e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387231811  775 RHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRLRCIPVHSFNGLRSLRVLTLHGNDI 835
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
61-121 3.18e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 3.18e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387231811   61 RNAERLDLDRNNITRITKTDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL 121
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
311-367 2.98e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.93  E-value: 2.98e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387231811  311 EIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI 367
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 636-714 2.49e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.96  E-value: 2.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  636 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 712
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 1387231811  713 GN 714
Cdd:TIGR00864   82 EE 83
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-217 6.62e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 6.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   61 RNAERLDLDRNNITRITKTDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK-LQVLPELLFQSNLKltRLD 139
Cdd:PLN00113   404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKfFGGLPDSFGSKRLE--NLD 481

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1387231811  140 LSENQILG-IPRKaFRGIADVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217
Cdd:PLN00113   482 LSRNQFSGaVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
522-790 6.95e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 6.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  522 KLARIPSHLPEYVTDLRLNDNEIsvleatgifKKLP-----NLRKINLSNNRIKEVKEGAFDgaaSVQELVLTGNQLETA 596
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  597 HGRAfrgLSGLKTLMLRSNLISCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 676
Cdd:PRK15370   257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  677 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgndesscqlgprCPEQCTCVETVVRCSNRGLRALPKGIPKDVTE 756
Cdd:PRK15370   322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1387231811  757 LYLEGNHLTAVPKELSSfrHLTLIDLSNNSIGML 790
Cdd:PRK15370   372 LDVSRNALTNLPENLPA--ALQIMQASRNNLVRL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 734-860 2.01e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 2.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  734 TVVRCSNRGLRALPK-GIPKDVTELYLEGNHLTAVPKeLSSFRHLTLIDLSNNSIGMLTNytFSNMSHLSTLILSYNRLR 812
Cdd:cd21340      5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387231811  813 CI-------------------P--------VHSFNGL-RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPLH 860
Cdd:cd21340     82 VVeglenltnleelhienqrlPpgekltfdPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1074-1110 1.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387231811 1074 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFSGLHCE 1110
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
857-906 3.89e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 3.89e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1387231811   857 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 906
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
50-363 6.13e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 6.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   50 LGLRAVPRGIPRNAERLDLDRNNITRITKTDFAGLKNLRVlhlednqvsviergafqdlkqlerlrlNKNKLQVLPELLF 129
Cdd:PRK15370   188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYA---------------------------NSNQLTSIPATLP 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  130 QSnlkLTRLDLSENQILGIPRkafRGIADVKNLQLDNNHISCIEDGAFRALRDLEILtlnNNNISrilvTSFNHMPK-IR 208
Cdd:PRK15370   241 DT---IQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPEELRYLSVY---DNSIR----TLPAHLPSgIT 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  209 TLRLHSNHLycdchlawlsdwlrqrrTVGPFTLcmaPVHLRGFNVADvqkkEYVCSGPHSEPPACNANSIS------CPS 282
Cdd:PRK15370   308 HLNVQSNSL-----------------TALPETL---PPGLKTLEAGE----NALTSLPASLPPELQVLDVSknqitvLPE 363

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  283 ACTCSNNIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGA---FTQYKKLKRIDISKNQISDiapDAFQGLKSLTS 359
Cdd:PRK15370   364 TLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESLphfRGEGPQPTRIIVEYNPFSE---RTIQNMQRLMS 440


                   ....
gi 1387231811  360 LVLY 363
Cdd:PRK15370   441 SVGY 444
EGF_CA smart00179
Calcium-binding EGF-like domain;
1074-1110 2.36e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.36e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1387231811  1074 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFS-GLHCE 1110
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 998-1031 4.44e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.44e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387231811  998 DDCED-NDCENNATCVDGVNNYVCVCPPNYTGELC 1031
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1035-1072 4.71e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.71e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387231811 1035 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYSGKLCE 1072
Cdd:cd00054      2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
255-377 6.91e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 6.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  255 DVQKKEYVCSGPHSEPPAcNANSISCPSACTCSNNIVDCRGK-GLTEIPANLPEGIVEIRLEQNSIKSIPAGAftqYKKL 333
Cdd:PRK15370   147 ELIWSEWVKEAPAKEAAN-REEAVQRMRDCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENL---QGNI 222

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387231811  334 KRIDISKNQISDIA---PDAFQGLK---------------SLTSLVLYGNKITEIPKGLFDG 377
Cdd:PRK15370   223 KTLYANSNQLTSIPatlPDTIQEMElsinritelperlpsALQSLDLFHNKISCLPENLPEE 284
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-250 1.89e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 1.89e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387231811  188 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVGP-FTLCMAPVHLRG 250
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQPeAALCAGPGALAG 67
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1078-1108 3.37e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.37e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1387231811 1078 CAAHRCRHGAQCVDAVNGYTCICPQGFSGLH 1108
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 962-994 3.52e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.52e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1387231811  962 NPCLHGGTCHLSEthkGGFSCSCPLGFEGQRCE 994
Cdd:cd00054      9 NPCQNGGTCVNTV---GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1123-1153 3.61e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.61e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1387231811 1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1153
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 412-473 7.25e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.77  E-value: 7.25e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387231811  412 DNKLQTISKGLFAPLQAIQTLHLAQNPFVCDCHLRWLADYLQDNPIET---SGARCSSPRRLANK 473
Cdd:TIGR00864    4 NNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1000-1029 7.54e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 7.54e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1387231811 1000 CEDNDCENNATCVDGVNNYVCVCPPNYTGE 1029
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 7.95e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.95e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1387231811    33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 725-751 7.99e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.07  E-value: 7.99e-05
                           10        20
                   ....*....|....*....|....*..
gi 1387231811  725 CPEQCTCVETVVRCSNRGLRALPKGIP 751
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 8.73e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 8.73e-05
                           10        20
                   ....*....|....*....|....*...
gi 1387231811   33 ACPTKCTCSAASVDCHGLGLRAVPRGIP 60
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
1035-1072 9.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 9.18e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1387231811  1035 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYS-GKLCE 1072
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
998-1027 1.31e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.31e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1387231811   998 DDCE-DNDCENNATCVDGVNNYVCVCPPNYT 1027
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
LRRCT smart00082
Leucine rich repeat C-terminal domain;
437-467 4.36e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 4.36e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1387231811   437 NPFVCDCHLRWLADYLQDNPI--ETSGARCSSP 467
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
LRRNT smart00013
Leucine rich repeat N-terminal domain;
505-535 1.02e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 1.02e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1387231811   505 CPDRCRCEGTIVDCSNQKLARIPSHLPEYVT 535
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 959-992 2.75e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1387231811  959 CIQNPCLHGGTCHlseTHKGGFSCSCPLGFEGQR 992
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1045-1069 2.78e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.78e-03
                           10        20
                   ....*....|....*....|....*
gi 1387231811 1045 CQHEAKCISLDRGFRCECPPGYSGK 1069
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGK 30
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1466-1519 4.43e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 37.77  E-value: 4.43e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1387231811  1466 SCATASKIPVMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEELERHLECGC 1519
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGC 77
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 918-953 5.58e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387231811  918 DPCLS-SPCKNNGTCsQDPVEGHRCACSHGYKGRDCT 953
Cdd:cd00054      3 DECASgNPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 920-951 5.58e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1387231811  920 CLSSPCKNNGTCSQDPvEGHRCACSHGYKGRD 951
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
962-994 7.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 7.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1387231811   962 NPCLHGGTCHLSEthkGGFSCSCPLGFE-GQRCE 994
Cdd:smart00179    9 NPCQNGGTCVNTV---GSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1188-1314 5.49e-32

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 121.37  E-value: 5.49e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811 1188 TDKDNGILLYKGD--NDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKL 1265
Cdd:pfam02210    3 TRQPNGLLLYAGGggSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSSLPP 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1387231811 1266 QKQPAVSINSPLYLGGIPTSTGLSALRQGMdrplgGFHGCIHEVRINNE 1314
Cdd:pfam02210   83 GESLLLNLNGPLYLGGLPPLLLLPALPVRA-----GFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1159-1312 4.15e-31

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 119.83  E-value: 4.15e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811 1159 TVNFVGkDSYVELA-SAKVRPQANISLQVATDKDNGILLYKGD---NDPLALELYQGHVRLVYDsLSSPPTTVYSVETVN 1234
Cdd:cd00110      1 GVSFSG-SSYVRLPtLPAPRTRLSISFSFRTTSPNGLLLYAGSqngGDFLALELEDGRLVLRYD-LGSGSLVLSSKTPLN 78

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1387231811 1235 DGQFHSVELVMLNQTLNLVVDKGAPKSLGKLQKQPAVSINSPLYLGGIPTStglsaLRQGMDRPLGGFHGCIHEVRIN 1312
Cdd:cd00110     79 DGQWHSVSVERNGRSVTLSVDGERVVESGSPGGSALLNLDGPLYLGGLPED-----LKSPGLPVSPGFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1181-1314 5.00e-31

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 118.98  E-value: 5.00e-31
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  1181 NISLQVATDKDNGILLY---KGDNDPLALELYQGHVRLVYDSLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKG 1257
Cdd:smart00282    1 SISFSFRTTSPNGLLLYagsKGGGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                            90       100       110       120       130
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387231811  1258 APKSLGKLQKQPAVSINSPLYLGGIPTSTGLSALRQGmdrplGGFHGCIHEVRINNE 1314
Cdd:smart00282   81 NRVSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVT-----PGFRGCIRNLKVNGK 132
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-217 1.14e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 114.65  E-value: 1.14e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   62 NAERLDLDRNNITRITKtDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLfqSNLK-LTRLDL 140
Cdd:COG4886    114 NLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEEL--GNLTnLKELDL 189

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1387231811  141 SENQILGIPrKAFRGIADVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRIlvTSFNHMPKIRTLRLHSNHL 217
Cdd:COG4886    190 SNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDL--PELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
66-370 2.61e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.71  E-value: 2.61e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   66 LDLDRNNITRITKTDFAGLKNLRVLHLEDNQvsviergAFQDLKQLERLRLNKNKLQVLPELLfqSNLK-LTRLDLSENQ 144
Cdd:COG4886     77 LSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEEL--ANLTnLKELDLSNNQ 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  145 ILGIPrkafRGIADVKNLQ---LDNNHISCIeDGAFRALRDLEILTLNNNNISRILvTSFNHMPKIRTLRLHSNHlycdc 221
Cdd:COG4886    148 LTDLP----EPLGNLTNLKsldLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLP-EPLGNLTNLEELDLSGNQ----- 216

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  222 hlawlsdwlrqrrtvgpftlcmapvhlrgfnvadvqkkeyvcsgphseppacnansiscpsactcsnnivdcrgkgLTEI 301
Cdd:COG4886    217 ----------------------------------------------------------------------------LTDL 220

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387231811  302 PANLPE--GIVEIRLEQNSIKSIPagAFTQYKKLKRIDISKNQISDIAPDAfqGLKSLTSLVLYGNKITEI 370
Cdd:COG4886    221 PEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL 287
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
535-900 3.05e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 104.25  E-value: 3.05e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  535 TDLRLNDNEISVLEATGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQletahgrAFRGLSGLKTLMLRS 614
Cdd:COG4886     50 TLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSG 122

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  615 NLISCVSNDtFAGLSSVRLLSLYDNRITTItPGAFTTLVSLSTINLLSNPfncnchlawlgkwlrkrrivsgnprcqkpf 694
Cdd:COG4886    123 NQLTDLPEE-LANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQ------------------------------ 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  695 fLKEIPiqdvaiqdftcdgndesscqlgprcpeqctcvetvvrcsnRGLRALPKgipkdVTELYLEGNHLTAVPKELSSF 774
Cdd:COG4886    171 -LTDLP----------------------------------------EELGNLTN-----LKELDLSNNQITDLPEPLGNL 204

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  775 RHLTLIDLSNNSIGMLTNyTFSNMSHLSTLILSYNRLRCIPvhSFNGLRSLRVLTLHGNDISSVPEGSfnDLTSLSHLAL 854
Cdd:COG4886    205 TNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDL 279

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*.
gi 1387231811  855 GTNPLHcDCSLRWLSEWVKAGYKEPGIARCSSPEPMADRLLLTTPT 900
Cdd:COG4886    280 SNNQLT-DLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLL 324
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-450 1.39e-22

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.32  E-value: 1.39e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   62 NAERLDLDRNNitritktDFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKLQVLPELLfqSNLK-LTRLDL 140
Cdd:COG4886     97 NLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPL--GNLTnLKSLDL 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  141 SENQILGIPrKAFRGIADVKNLQLDNNHISCIEDgAFRALRDLEILTLNNNNISRiLVTSFNHMPKIRTLRLHSNHLycd 220
Cdd:COG4886    167 SNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD-LPEPLANLTNLETLDLSNNQL--- 240

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  221 chlawlsdwlrqrrtvgpftlcmapvhlrgfnvadvqkkeyvcsgphseppacnansiscpsactcsnnivdcrgkglTE 300
Cdd:COG4886    241 ------------------------------------------------------------------------------TD 242

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  301 IP--ANLPEgIVEIRLEQNSIKSIPAGAftQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIPkgLFDGL 378
Cdd:COG4886    243 LPelGNLTN-LEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLE--LLILL 317

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387231811  379 VSLQLLLLNANKINCLRVNTFQDLQSLSLLSLYDNKLQTISKGLFAPLQAIQTLHLAQNPFVCDCHLRWLAD 450
Cdd:COG4886    318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTL 389
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
633-859 2.01e-21

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 98.85  E-value: 2.01e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  633 LLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPRCQkpfFLKEIPIQDVAIQDFTCD 712
Cdd:COG4886      2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDL---LLSSLLLLLSLLLLLLLS 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  713 GNDESSCQLGPRCPEQCTCVETVVRCSNRGLRALpkgipKDVTELYLEGNHLTAVPKELSSFRHLTLIDLSNNSIGMLTN 792
Cdd:COG4886     79 LLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE 153

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1387231811  793 yTFSNMSHLSTLILSYNRLRCIPvHSFNGLRSLRVLTLHGNDISSVPEgSFNDLTSLSHLALGTNPL 859
Cdd:COG4886    154 -PLGNLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQL 217
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
514-665 3.13e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 95.39  E-value: 3.13e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  514 TIVDCSNQKLARIPSHLPE--YVTDLRLNDNEISVLEATgiFKKLPNLRKINLSNNRIKEVKEgAFDGAASVQELVLTGN 591
Cdd:COG4886    116 ESLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEP--LGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387231811  592 QLETAHGrAFRGLSGLKTLMLRSNLISCVSnDTFAGLSSVRLLSLYDNRITTITpgAFTTLVSLSTINLLSNPF 665
Cdd:COG4886    193 QITDLPE-PLGNLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-217 6.83e-20

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 94.23  E-value: 6.83e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   44 SVDCHGLGLRAVPRGIPR--NAERLDLDRNNITRITKTdFAGLKNLRVLHLEDNQVSVIERgAFQDLKQLERLRLNKNKL 121
Cdd:COG4886    163 SLDLSNNQLTDLPEELGNltNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQL 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  122 QVLPELlfqSNL-KLTRLDLSENQILGIPrkAFRGIADVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTS 200
Cdd:COG4886    241 TDLPEL---GNLtNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLI 315

                          170
                   ....*....|....*..
gi 1387231811  201 FNHMPKIRTLRLHSNHL 217
Cdd:COG4886    316 LLLLLTTLLLLLLLLKG 332
Laminin_G_1 pfam00054
Laminin G domain;
1186-1317 9.14e-20

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 86.60  E-value: 9.14e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811 1186 VATDKDNGILLYKGDNDP---LALELYQGHVRLVYDsLSSPPTTVYSVETVNDGQFHSVELVMLNQTLNLVVDKGAP--- 1259
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTErdfLALELRDGRLEVSYD-LGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARptg 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387231811 1260 -KSLGKLQKqpaVSINSPLYLGGIPtSTGLSALRQGMDRplgGFHGCIHEVRINNELQD 1317
Cdd:pfam00054   80 eSPLGATTD---LDVDGPLYVGGLP-SLGVKKRRLAISP---SFDGCIRDVIVNGKPLD 131
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
107-372 1.17e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.38  E-value: 1.17e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  107 DLKQLERLRLNKNKLQVLPELLFQSNLKLTRLDLSENQILGiprkafrGIADVKNLQLDNNHISCIEDgAFRALRDLEIL 186
Cdd:COG4886     70 SLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-------NLTNLESLDLSGNQLTDLPE-ELANLTNLKEL 141

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  187 TLNNNNISRIlVTSFNHMPKIRTLRLHSNHLYCdchlawLSDWLrqrrtvGPFTlcmapvHLRGFNVadvqkkeyvcsgp 266
Cdd:COG4886    142 DLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTD------LPEEL------GNLT------NLKELDL------------- 189

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  267 hseppacnansiscpsactcSNNivdcrgkGLTEIPANL--PEGIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQIS 344
Cdd:COG4886    190 --------------------SNN-------QITDLPEPLgnLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT 241

                          250       260
                   ....*....|....*....|....*...
gi 1387231811  345 DIApdAFQGLKSLTSLVLYGNKITEIPK 372
Cdd:COG4886    242 DLP--ELGNLTNLEELDLSNNQLTDLPP 267
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-459 2.90e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 2.90e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  290 IVDCRGKGLTEIPANLPE--GIVEIRLEQNSIKSIPAgAFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKI 367
Cdd:COG4886    117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQI 194

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  368 TEIPKGLFDglvslqllLLNANKINClrvntfqdlqslsllslYDNKLQTISKGLfAPLQAIQTLHLAQN-----PFVCD 442
Cdd:COG4886    195 TDLPEPLGN--------LTNLEELDL-----------------SGNQLTDLPEPL-ANLTNLETLDLSNNqltdlPELGN 248

                          170
                   ....*....|....*...
gi 1387231811  443 C-HLRWLadYLQDNPIET 459
Cdd:COG4886    249 LtNLEEL--DLSNNQLTD 264
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
326-666 2.98e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.14  E-value: 2.98e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  326 AFTQYKKLKRIDISKNQISDIaPDAFQGLKSLTSLVLYGNKITEIPKGLFdglvslqllllNANKINCLRVntfqdlqsl 405
Cdd:COG4886    108 ELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLG-----------NLTNLKSLDL--------- 166

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  406 sllslYDNKLQTISKGLfAPLQaiqtlhlaqnpfvcdcHLRWLadYLQDNPIETSGARCSSPRRLankrisqikskkfrc 485
Cdd:COG4886    167 -----SNNQLTDLPEEL-GNLT----------------NLKEL--DLSNNQITDLPEPLGNLTNL--------------- 207

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  486 sgsedyrsrfssecfmdlvcpdrcrcegTIVDCSNQKLARIPSHLPEY--VTDLRLNDNEISVLEAtgiFKKLPNLRKIN 563
Cdd:COG4886    208 ----------------------------EELDLSGNQLTDLPEPLANLtnLETLDLSNNQLTDLPE---LGNLTNLEELD 256

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  564 LSNNRIKEVKEGAfdGAASVQELVLTGNQLETAHGRAFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITT 643
Cdd:COG4886    257 LSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                          330       340
                   ....*....|....*....|...
gi 1387231811  644 ITPGAFTTLVSLSTINLLSNPFN 666
Cdd:COG4886    335 VTLTTLALSLSLLALLTLLLLLN 357
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 61-217 9.70e-16

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 77.90  E-value: 9.70e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   61 RNAERLDLDRNNITRITktDFAGLKNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKLQVLPELLFQSNL------K 134
Cdd:cd21340     46 TNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPPGEKLTFDPRSlaalsnS 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  135 LTRLDLSenqilgiprkafrgiadvknlqldNNHISCIEDgaFRALRDLEILTLNNNNISRI--LVTSFNHMPKIRTLRL 212
Cdd:cd21340    122 LRVLNIS------------------------GNNIDSLEP--LAPLRNLEQLDASNNQISDLeeLLDLLSSWPSLRELDL 175


                   ....*
gi 1387231811  213 HSNHL 217
Cdd:cd21340    176 TGNPV 180
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
301-665 9.75e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.44  E-value: 9.75e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  301 IPANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNqisdiapDAFQGLKSLTSLVLYGNKITEIPKGLfdglvs 380
Cdd:COG4886     66 LLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEEL------ 132

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  381 lqllllnankinclrvntfqdlqslsllslydnklqtiskglfAPLQAIQTLHLAQNpfvcdchlrwladylqdnpiets 460
Cdd:COG4886    133 -------------------------------------------ANLTNLKELDLSNN----------------------- 146

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  461 garcssprrlankRISQIKSkkfrcsgsedyrsrfssecfmdlvcpdrcrcegTIVDCSNqklaripshlpeyVTDLRLN 540
Cdd:COG4886    147 -------------QLTDLPE---------------------------------PLGNLTN-------------LKSLDLS 167

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  541 DNEISVLEATgiFKKLPNLRKINLSNNRIKEVKEgAFDGAASVQELVLTGNQLETAhGRAFRGLSGLKTLMLRSNLISCV 620
Cdd:COG4886    168 NNQLTDLPEE--LGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDL 243

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 1387231811  621 SNdtFAGLSSVRLLSLYDNRITTITPGAftTLVSLSTINLLSNPF 665
Cdd:COG4886    244 PE--LGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
775-835 2.28e-14

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 69.09  E-value: 2.28e-14
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387231811  775 RHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRLRCIPVHSFNGLRSLRVLTLHGNDI 835
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
61-121 3.18e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.62  E-value: 3.18e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387231811   61 RNAERLDLDRNNITRITKTDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKL 121
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
582-641 4.18e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 4.18e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  582 SVQELVLTGNQLETAHGRAFRGLSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRI 641
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
311-367 2.98e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.93  E-value: 2.98e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387231811  311 EIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKI 367
Cdd:pfam13855    5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
159-217 3.01e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 62.93  E-value: 3.01e-12
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387231811  159 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
605-665 6.97e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 6.97e-12
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387231811  605 SGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPF 665
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
799-859 1.83e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 60.62  E-value: 1.83e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387231811  799 SHLSTLILSYNRLRCIPVHSFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Cdd:pfam13855    1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 636-714 2.49e-11

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 68.96  E-value: 2.49e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  636 LYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRKRRIVSGNPR---CQKPFFLKEIPIQDVAIQDFTCD 712
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEaalCAGPGALAGQPLLGIPLLDSGCD 81


                   ..
gi 1387231811  713 GN 714
Cdd:TIGR00864   82 EE 83
LRR_8 pfam13855
Leucine rich repeat;
534-593 3.43e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 3.43e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  534 VTDLRLNDNEISVLEAtGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQL 593
Cdd:pfam13855    3 LRSLDLSNNRLTSLDD-GAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
134-193 3.85e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 59.85  E-value: 3.85e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  134 KLTRLDLSENQILGIPRKAFRGIADVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNI 193
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
86-145 1.23e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.30  E-value: 1.23e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   86 NLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSNLKLTRLDLSENQI 145
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
110-169 1.65e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 57.92  E-value: 1.65e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  110 QLERLRLNKNKLQVLPELLFQSNLKLTRLDLSENQILGIPRKAFRGIADVKNLQLDNNHI 169
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-203 4.69e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 4.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   52 LRAVPRGIPR--NAERLDLDRNNITRITktDFAGLKNLRVLHLEDNQVSVIerGAFQDLKQLERLRLNKNK-----LQVL 124
Cdd:COG4886    217 LTDLPEPLANltNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQltdlkLKEL 292

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1387231811  125 PELLFQSNLKLTRLDLSENQILGIPRKAFRGIADVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNH 203
Cdd:COG4886    293 ELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGL 371
LRR_8 pfam13855
Leucine rich repeat;
754-811 5.12e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 5.12e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387231811  754 VTELYLEGNHLTAVPKE-LSSFRHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRL 811
Cdd:pfam13855    3 LRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 61-217 6.62e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 60.63  E-value: 6.62e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   61 RNAERLDLDRNNITRITKTDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNK-LQVLPELLFQSNLKltRLD 139
Cdd:PLN00113   404 RSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKfFGGLPDSFGSKRLE--NLD 481

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1387231811  140 LSENQILG-IPRKaFRGIADVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHL 217
Cdd:PLN00113   482 LSRNQFSGaVPRK-LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
522-790 6.95e-09

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 60.48  E-value: 6.95e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  522 KLARIPSHLPEYVTDLRLNDNEIsvleatgifKKLP-----NLRKINLSNNRIKEVKEGAFDgaaSVQELVLTGNQLETA 596
Cdd:PRK15370   189 GLTTIPACIPEQITTLILDNNEL---------KSLPenlqgNIKTLYANSNQLTSIPATLPD---TIQEMELSINRITEL 256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  597 HGRAfrgLSGLKTLMLRSNLISCVSNDTFAGLssvRLLSLYDNRITTItPGAFTTlvSLSTINLLSNPfncnchLAWLGK 676
Cdd:PRK15370   257 PERL---PSALQSLDLFHNKISCLPENLPEEL---RYLSVYDNSIRTL-PAHLPS--GITHLNVQSNS------LTALPE 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  677 WLrkrrivsgnprcqkPFFLKEIPIQDVAIqdfTCdgndesscqlgprCPEQCTCVETVVRCSNRGLRALPKGIPKDVTE 756
Cdd:PRK15370   322 TL--------------PPGLKTLEAGENAL---TS-------------LPASLPPELQVLDVSKNQITVLPETLPPTITT 371

                          250       260       270
                   ....*....|....*....|....*....|....
gi 1387231811  757 LYLEGNHLTAVPKELSSfrHLTLIDLSNNSIGML 790
Cdd:PRK15370   372 LDVSRNALTNLPENLPA--ALQIMQASRNNLVRL 403
LRR_8 pfam13855
Leucine rich repeat;
332-377 9.58e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 9.58e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1387231811  332 KLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIPKGLFDG 377
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG 47
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 830-905 1.15e-08

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 60.48  E-value: 1.15e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1387231811  830 LHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK---AGYKEPGIARCSSPEPMADRLLLTTPTHRFQC 905
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEekgVKVRQPEAALCAGPGALAGQPLLGIPLLDSGC 80
PLN03150 PLN03150
hypothetical protein; Provisional
 767-860 1.17e-08

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 59.83  E-value: 1.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  767 VPKELSSFRHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRLR-CIPvHSFNGLRSLRVLTLHGNDISS-VPEgsfn 844
Cdd:PLN03150   434 IPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNgSIP-ESLGQLTSLRILNLNGNSLSGrVPA---- 508

                           90
                   ....*....|....*.
gi 1387231811  845 dltslshlALGTNPLH 860
Cdd:PLN03150   509 --------ALGGRLLH 516
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 734-860 2.01e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 2.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  734 TVVRCSNRGLRALPK-GIPKDVTELYLEGNHLTAVPKeLSSFRHLTLIDLSNNSIGMLTNytFSNMSHLSTLILSYNRLR 812
Cdd:cd21340      5 THLYLNDKNITKIDNlSLCKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRIS 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387231811  813 CI-------------------P--------VHSFNGL-RSLRVLTLHGNDISSVpeGSFNDLTSLSHLALGTNPLH 860
Cdd:cd21340     82 VVeglenltnleelhienqrlPpgekltfdPRSLAALsNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQIS 155
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 534-859 5.01e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 57.94  E-value: 5.01e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  534 VTDLRLNDNEISVLEATGIFKkLPNLRKINLSNNRIK-EVKEGAFDGAASVQELVLTGNQLETAHGRAFrgLSGLKTLML 612
Cdd:PLN00113    71 VVSIDLSGKNISGKISSAIFR-LPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDL 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  613 RSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNC----------NCHLAWLG------- 675
Cdd:PLN00113   148 SNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGqiprelgqmkSLKWIYLGynnlsge 227

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  676 --------KWLRKRRIVSGNPRCQKP-----------FFLKE------IPIQDVAIQDF-TCDGNDESscqLGPRCPE-- 727
Cdd:PLN00113   228 ipyeigglTSLNHLDLVYNNLTGPIPsslgnlknlqyLFLYQnklsgpIPPSIFSLQKLiSLDLSDNS---LSGEIPElv 304

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  728 -QCTCVETVVRCSN-------RGLRALPKgipkdVTELYLEGNHLTA-VPKELSSFRHLTLIDLSNNSIGMLTNYTFSNM 798
Cdd:PLN00113   305 iQLQNLEILHLFSNnftgkipVALTSLPR-----LQVLQLWSNKFSGeIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSS 379

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387231811  799 SHLSTLILSYNRLRCIPVHSFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPL 859
Cdd:PLN00113   380 GNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNL 440
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1074-1110 1.18e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.18e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387231811 1074 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFSGLHCE 1110
Cdd:cd00054      1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LRRCT smart00082
Leucine rich repeat C-terminal domain;
857-906 3.89e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 48.20  E-value: 3.89e-07
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1387231811   857 NPLHCDCSLRWLSEWVKAG--YKEPGIARCSSPEPMADRlLLTTPTHRFQCK 906
Cdd:smart00082    1 NPFICDCELRWLLRWLQANehLQDPVDLRCASPSSLRGP-LLELLHSEFKCP 51
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 49-220 5.48e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 53.51  E-value: 5.48e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   49 GLGLRAVPRGIPRNA--ERLDLDRNNITRITKTDFAGL---KNLRVLHLEDNQVSV----IERGAFQDLK-QLERLRLNK 118
Cdd:cd00116     67 PRGLQSLLQGLTKGCglQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrglrLLAKGLKDLPpALEKLVLGR 146

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  119 NKLQVLP----ELLFQSNLKLTRLDLSENQIL--GIPRKAfRGIADVKNLQ---LDNNHISCIED----GAFRALRDLEI 185
Cdd:cd00116    147 NRLEGAScealAKALRANRDLKELNLANNGIGdaGIRALA-EGLKANCNLEvldLNNNGLTDEGAsalaETLASLKSLEV 225

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 1387231811  186 LTLNNNNIS----RILVTSFNHM-PKIRTLRLHSNHLYCD 220
Cdd:cd00116    226 LNLGDNNLTdagaAALASALLSPnISLLTLSLSCNDITDD 265
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
50-363 6.13e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 6.13e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   50 LGLRAVPRGIPRNAERLDLDRNNITRITKTDFAGLKNLRVlhlednqvsviergafqdlkqlerlrlNKNKLQVLPELLF 129
Cdd:PRK15370   188 LGLTTIPACIPEQITTLILDNNELKSLPENLQGNIKTLYA---------------------------NSNQLTSIPATLP 240

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  130 QSnlkLTRLDLSENQILGIPRkafRGIADVKNLQLDNNHISCIEDGAFRALRDLEILtlnNNNISrilvTSFNHMPK-IR 208
Cdd:PRK15370   241 DT---IQEMELSINRITELPE---RLPSALQSLDLFHNKISCLPENLPEELRYLSVY---DNSIR----TLPAHLPSgIT 307

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  209 TLRLHSNHLycdchlawlsdwlrqrrTVGPFTLcmaPVHLRGFNVADvqkkEYVCSGPHSEPPACNANSIS------CPS 282
Cdd:PRK15370   308 HLNVQSNSL-----------------TALPETL---PPGLKTLEAGE----NALTSLPASLPPELQVLDVSknqitvLPE 363

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  283 ACTCSNNIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGA---FTQYKKLKRIDISKNQISDiapDAFQGLKSLTS 359
Cdd:PRK15370   364 TLPPTITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPESLphfRGEGPQPTRIIVEYNPFSE---RTIQNMQRLMS 440


                   ....
gi 1387231811  360 LVLY 363
Cdd:PRK15370   441 SVGY 444
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
695-859 7.46e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 7.46e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  695 FLKEIPIQDVAiqdftcdgNDESSCQLGPRCPEQCtcvETVVRCSNRGLRALPKGIPKDVTELYLEGNHLTAVP------ 768
Cdd:PRK15370   153 WVKEAPAKEAA--------NREEAVQRMRDCLKNN---KTELRLKILGLTTIPACIPEQITTLILDNNELKSLPenlqgn 221

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  769 -KELSSFRH------------LTLIDLSNNSIGMLTNYTfsnMSHLSTLILSYNRLRCIPVHSFNGLRSLRVltlHGNDI 835
Cdd:PRK15370   222 iKTLYANSNqltsipatlpdtIQEMELSINRITELPERL---PSALQSLDLFHNKISCLPENLPEELRYLSV---YDNSI 295

                          170       180
                   ....*....|....*....|....
gi 1387231811  836 SSVPEgsfNDLTSLSHLALGTNPL 859
Cdd:PRK15370   296 RTLPA---HLPSGITHLNVQSNSL 316
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 535-665 1.45e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.94  E-value: 1.45e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  535 TDLRLNDNEISVLEAtgiFKKLPNLRKINLSNNRIKEVkEGaFDGAASVQELVLTGNQLETAHG-----RAFRGLSG-LK 608
Cdd:cd21340     49 THLYLQNNQIEKIEN---LENLVNLKKLYLGGNRISVV-EG-LENLTNLEELHIENQRLPPGEKltfdpRSLAALSNsLR 123

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387231811  609 TLMLRSNLISCVSNdtFAGLSSVRLLSLYDNRITTITP--GAFTTLVSLSTINLLSNPF 665
Cdd:cd21340    124 VLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPV 180
LRRNT smart00013
Leucine rich repeat N-terminal domain;
725-756 1.77e-06

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 45.77  E-value: 1.77e-06
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1387231811   725 CPEQCTCVETVVRCSNRGLRALPKGIPKDVTE 756
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1074-1110 2.36e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 2.36e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1387231811  1074 DDDDCA-AHRCRHGAQCVDAVNGYTCICPQGFS-GLHCE 1110
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 998-1031 4.44e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 4.44e-06
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387231811  998 DDCED-NDCENNATCVDGVNNYVCVCPPNYTGELC 1031
Cdd:cd00054      3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1035-1072 4.71e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 4.71e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387231811 1035 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYSGKLCE 1072
Cdd:cd00054      2 IDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
255-377 6.91e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 6.91e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  255 DVQKKEYVCSGPHSEPPAcNANSISCPSACTCSNNIVDCRGK-GLTEIPANLPEGIVEIRLEQNSIKSIPAGAftqYKKL 333
Cdd:PRK15370   147 ELIWSEWVKEAPAKEAAN-REEAVQRMRDCLKNNKTELRLKIlGLTTIPACIPEQITTLILDNNELKSLPENL---QGNI 222

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387231811  334 KRIDISKNQISDIA---PDAFQGLK---------------SLTSLVLYGNKITEIPKGLFDG 377
Cdd:PRK15370   223 KTLYANSNQLTSIPatlPDTIQEMElsinritelperlpsALQSLDLFHNKISCLPENLPEE 284
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 188-250 1.89e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 49.70  E-value: 1.89e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387231811  188 LNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR--RTVGP-FTLCMAPVHLRG 250
Cdd:TIGR00864    2 ISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKgvKVRQPeAALCAGPGALAG 67
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 66-374 3.15e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 3.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   66 LDLDRNNITRITKTDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ-VLPELLFQSNlKLTRLDLSENQ 144
Cdd:PLN00113   289 LDLSDNSLSGEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHN-NLTVLDLSTNN 367

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  145 ILG-IPR-----------------------KAFRGIADVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTS 200
Cdd:PLN00113   368 LTGeIPEglcssgnlfklilfsnslegeipKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSR 447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  201 FNHMPKIRTLRLHSNHLYCDchlawLSDWLRQRRtvgpftlcmapvhLRGFNVADvqkkeyvcsgphseppacNANSISC 280
Cdd:PLN00113   448 KWDMPSLQMLSLARNKFFGG-----LPDSFGSKR-------------LENLDLSR------------------NQFSGAV 491

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  281 PSACtcsnnivdcrgkglteipANLPEgIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSL 360
Cdd:PLN00113   492 PRKL------------------GSLSE-LMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQL 552

                          330
                   ....*....|....*
gi 1387231811  361 VLYGNKIT-EIPKGL 374
Cdd:PLN00113   553 DLSQNQLSgEIPKNL 567
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1078-1108 3.37e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.37e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1387231811 1078 CAAHRCRHGAQCVDAVNGYTCICPQGFSGLH 1108
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 962-994 3.52e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.52e-05
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1387231811  962 NPCLHGGTCHLSEthkGGFSCSCPLGFEGQRCE 994
Cdd:cd00054      9 NPCQNGGTCVNTV---GSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1123-1153 3.61e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 3.61e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1387231811 1123 CDQYECQNGAQCIVVQQEPTCRCPPGFAGPR 1153
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 66-370 4.34e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 4.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   66 LDLDRNNITRITktDFAGLKNLRVLHLEDNQVSVIErgafqdlkQLERLRlnknklqvlpellfqsnlKLTRLdlsenqi 145
Cdd:cd21340      7 LYLNDKNITKID--NLSLCKNLKVLYLYDNKITKIE--------NLEFLT------------------NLTHL------- 51

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  146 lgiprkafrgiadvknlQLDNNHISCIEDgaFRALRDLEILTLNNNNISRilVTSFNHMPKIRTLRLhsnhlycdchlaw 225
Cdd:cd21340     52 -----------------YLQNNQIEKIEN--LENLVNLKKLYLGGNRISV--VEGLENLTNLEELHI------------- 97

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  226 lsdwLRQRrtvgpftlcmapvhlrgfnvadvqkkeyvcsgphseppacnansiscpsactcsnnivdcrgkglteipanL 305
Cdd:cd21340     98 ----ENQR-----------------------------------------------------------------------L 102

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387231811  306 PEGiVEIRLEQNSIKSIPagaftqyKKLKRIDISKNQISDIAPdaFQGLKSLTSLVLYGNKITEI 370
Cdd:cd21340    103 PPG-EKLTFDPRSLAALS-------NSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDL 157
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 64-170 4.34e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 4.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   64 ERLDLDRNNITRiTKTDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ-VLPELLfQSNLKLTRLDLSE 142
Cdd:PLN00113   455 QMLSLARNKFFG-GLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDEL-SSCKKLVSLDLSH 532

                           90       100
                   ....*....|....*....|....*....
gi 1387231811  143 NQILG-IPrKAFRGIADVKNLQLDNNHIS 170
Cdd:PLN00113   533 NQLSGqIP-ASFSEMPVLSQLDLSQNQLS 560
LRRCT smart00082
Leucine rich repeat C-terminal domain;
663-712 6.66e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 41.65  E-value: 6.66e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1387231811   663 NPFNCNCHLAWLGKWLRKRRIVSG--NPRCQKPFFLKEiPIQDVAIQDFTCD 712
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHLQDpvDLRCASPSSLRG-PLLELLHSEFKCP 51
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 412-473 7.25e-05

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 47.77  E-value: 7.25e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387231811  412 DNKLQTISKGLFAPLQAIQTLHLAQNPFVCDCHLRWLADYLQDNPIET---SGARCSSPRRLANK 473
Cdd:TIGR00864    4 NNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVrqpEAALCAGPGALAGQ 68
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-374 7.40e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 7.40e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   55 VPR--GIPRNAERLDLDRNNITRITKTDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQ-VLPELLFqS 131
Cdd:PLN00113   204 IPRelGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIF-S 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  132 NLKLTRLDLSENQILG-IPRKafrgIADVKNLQ---LDNNHISCIEDGAFRALRDLEILTLNNNNISrilvtsfNHMPKi 207
Cdd:PLN00113   283 LQKLISLDLSDNSLSGeIPEL----VIQLQNLEilhLFSNNFTGKIPVALTSLPRLQVLQLWSNKFS-------GEIPK- 350

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  208 rTLRLHSNHLYCDCHLAWLSDWLrqrrtvgPFTLCmapvhlrgfNVADVQKKEYVCSGPHSEPPacnansiscPSACTC- 286
Cdd:PLN00113   351 -NLGKHNNLTVLDLSTNNLTGEI-------PEGLC---------SSGNLFKLILFSNSLEGEIP---------KSLGACr 404

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  287 --------SNNIVDCRGKGLTEIPA---------NLPEGIVEIRLEQNSIK--SIPAGAFT-------QYKKLKRIDISK 340
Cdd:PLN00113   405 slrrvrlqDNSFSGELPSEFTKLPLvyfldisnnNLQGRINSRKWDMPSLQmlSLARNKFFgglpdsfGSKRLENLDLSR 484

                          330       340       350
                   ....*....|....*....|....*....|....*
gi 1387231811  341 NQISDIAPDAFQGLKSLTSLVLYGNKIT-EIPKGL 374
Cdd:PLN00113   485 NQFSGAVPRKLGSLSELMQLKLSENKLSgEIPDEL 519
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1000-1029 7.54e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 7.54e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 1387231811 1000 CEDNDCENNATCVDGVNNYVCVCPPNYTGE 1029
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-64 7.95e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 41.15  E-value: 7.95e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1387231811    33 ACPTKCTCSAASVDCHGLGLRAVPRGIPRNAE 64
Cdd:smart00013    1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 725-751 7.99e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 41.07  E-value: 7.99e-05
                           10        20
                   ....*....|....*....|....*..
gi 1387231811  725 CPEQCTCVETVVRCSNRGLRALPKGIP 751
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-60 8.73e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 40.69  E-value: 8.73e-05
                           10        20
                   ....*....|....*....|....*...
gi 1387231811   33 ACPTKCTCSAASVDCHGLGLRAVPRGIP 60
Cdd:pfam01462    1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
EGF_CA smart00179
Calcium-binding EGF-like domain;
1035-1072 9.18e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 9.18e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 1387231811  1035 IDHCVPGmNLCQHEAKCISLDRGFRCECPPGYS-GKLCE 1072
Cdd:smart00179    2 IDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
998-1027 1.31e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.31e-04
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1387231811   998 DDCE-DNDCENNATCVDGVNNYVCVCPPNYT 1027
Cdd:smart00179    3 DECAsGNPCQNGGTCVNTVGSYRCECPPGYT 33
LRR_9 pfam14580
Leucine-rich repeat;
539-643 2.25e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 43.60  E-value: 2.25e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  539 LNDNEISVLEAtgiFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNqletahgrafrglsglktlmlrsNLIS 618
Cdd:pfam14580   49 FSDNEIRKLDG---FPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNN-----------------------NLQE 102

                           90       100
                   ....*....|....*....|....*
gi 1387231811  619 CVSNDTFAGLSSVRLLSLYDNRITT 643
Cdd:pfam14580  103 LGDLDPLASLKKLTFLSLLRNPVTN 127
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 65-215 2.27e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 2.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   65 RLDLDRNNITRI-TKTDFAGLKNLRVLHLEDNQVSVIE----RGAFQDLKQLERLRLNKNKLQVLPELL------FQSNL 133
Cdd:cd00116      2 QLSLKGELLKTErATELLPKLLCLQVLRLEGNTLGEEAakalASALRPQPSLKELCLSLNETGRIPRGLqsllqgLTKGC 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  134 KLTRLDLSEN--QILGIPR-KAFRGIADVKNLQLDNN--------------------------------HISCIE-DGAF 177
Cdd:cd00116     82 GLQELDLSDNalGPDGCGVlESLLRSSSLQELKLNNNglgdrglrllakglkdlppaleklvlgrnrleGASCEAlAKAL 161

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 1387231811  178 RALRDLEILTLNNNNIS----RILVTSFNHMPKIRTLRLHSN 215
Cdd:cd00116    162 RANRDLKELNLANNGIGdagiRALAEGLKANCNLEVLDLNNN 203
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1083-1104 2.32e-04

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 39.62  E-value: 2.32e-04
                           10        20
                   ....*....|....*....|..
gi 1387231811 1083 CRHGAQCVDAVNGYTCICPQGF 1104
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 331-371 2.81e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.92  E-value: 2.81e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387231811  331 KKLKRIDISKNQISDIapDAFQGLKSLTSLVLYGN-KITEIP 371
Cdd:pfam12799    1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGNnKITDLS 40
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 60-145 3.01e-04

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.17  E-value: 3.01e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   60 PRNAERLDLDRNNIT-----RITKTdFAGLKNLRVLHLEDNQVSviERGA------FQDLKQLERLRLNKNKLQV----- 123
Cdd:COG5238    263 NTTVETLYLSGNQIGaegaiALAKA-LQGNTTLTSLDLSVNRIG--DEGAialaegLQGNKTLHTLNLAYNGIGAqgaia 339

                           90       100
                   ....*....|....*....|..
gi 1387231811  124 LPELLfQSNLKLTRLDLSENQI 145
Cdd:COG5238    340 LAKAL-QENTTLHSLDLSDNQI 360
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 273-377 3.38e-04

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 42.15  E-value: 3.38e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  273 CNANSISCPSACT---------CSNnivdcrgkgLTEIpaNLPEGIVEIR--------LE----QNSIKSIPAGAFTQYK 331
Cdd:pfam13306   11 CSLTSITIPSSLTsigeyafsnCTS---------LKSI--TLPSSLTSIGsyafyncsLTsitiPSSLTSIGEYAFSNCS 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 1387231811  332 KLKRIDISKNqISDIAPDAFQGLkSLTSLVLyGNKITEIPKGLFDG 377
Cdd:pfam13306   80 NLKSITLPSN-LTSIGSYAFSNC-SLKSITI-PSSVTTIGSYAFSN 122
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 741-811 3.95e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.22  E-value: 3.95e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387231811  741 RGLRALPkgipkDVTELYLEGNHLTAV-PKELSSFRHLTLIDLSNNSIGMLTNYTFSNMSHLSTLILSYNRL 811
Cdd:PLN00113   493 RKLGSLS-----ELMQLKLSENKLSGEiPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQL 559
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1077-1110 4.30e-04

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 39.00  E-value: 4.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1387231811 1077 DCAA-HRCRHGAQCVDAVNGYTCICPQGFSG-LHCE 1110
Cdd:cd00053      1 ECAAsNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
LRRCT smart00082
Leucine rich repeat C-terminal domain;
437-467 4.36e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.72  E-value: 4.36e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1387231811   437 NPFVCDCHLRWLADYLQDNPI--ETSGARCSSP 467
Cdd:smart00082    1 NPFICDCELRWLLRWLQANEHlqDPVDLRCASP 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 134-666 4.76e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.84  E-value: 4.76e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  134 KLTRLDLSENQILGIPRKAFRGIADVKNLQLDNNHISC-IEDGAFRALRDLEILTLNNNNISRILVTSFnhMPKIRTLRL 212
Cdd:PLN00113    70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGS--IPNLETLDL 147

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  213 HSNHLYCDCHLawlsdwlrqrrTVGPFTlcmapvhlrGFNVADVQKKEYVcsgphSEPPACNANSISCPSACTCSNNIVD 292
Cdd:PLN00113   148 SNNMLSGEIPN-----------DIGSFS---------SLKVLDLGGNVLV-----GKIPNSLTNLTSLEFLTLASNQLVG 202

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  293 crgkgltEIPANLPE--GIVEIRLEQNSIK-SIPAgAFTQYKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKIT- 368
Cdd:PLN00113   203 -------QIPRELGQmkSLKWIYLGYNNLSgEIPY-EIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSg 274

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  369 EIPKGLFdglvslqllllNANKINCLRVNtfqdlqslsllslyDNKLQTISKGLFAPLQAIQTLHLAQNPFVCdchlrwl 448
Cdd:PLN00113   275 PIPPSIF-----------SLQKLISLDLS--------------DNSLSGEIPELVIQLQNLEILHLFSNNFTG------- 322

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  449 adylqdnpiETSGARCSSPRRlankRISQIKSKKFRCSGSEDYRSRfSSECFMDLVC-------PDRCRCEGTIVDC--- 518
Cdd:PLN00113   323 ---------KIPVALTSLPRL----QVLQLWSNKFSGEIPKNLGKH-NNLTVLDLSTnnltgeiPEGLCSSGNLFKLilf 388

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  519 SNQKLARIPSHLP--EYVTDLRLNDNEISVlEATGIFKKLPNLRKINLSNNRIKEVKEGAFDGAASVQELVLTGNQLETA 596
Cdd:PLN00113   389 SNSLEGEIPKSLGacRSLRRVRLQDNSFSG-ELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGG 467

                          490       500       510       520       530       540       550
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  597 HGRAFRGlSGLKTLMLRSNLISCVSNDTFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFN 666
Cdd:PLN00113   468 LPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLS 536
LRRNT smart00013
Leucine rich repeat N-terminal domain;
280-311 6.07e-04

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.45  E-value: 6.07e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1387231811   280 CPSACTCSNNIVDCRGKGLTEIPANLPEGIVE 311
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTTL 33
Laminin_G_3 pfam13385
Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin ...
 1164-1311 6.09e-04

Concanavalin A-like lectin/glucanases superfamily; This domain belongs to the Concanavalin A-like lectin/glucanases superfamily.


Pssm-ID: 463865 [Multi-domain]  Cd Length: 151  Bit Score: 41.99  E-value: 6.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811 1164 GKDSYVELASAKVRPQAN-ISLQVATDKDNG---ILLYKGDNDPLALELYQ-GHVRLVYDSLSSPPTTVYSVETVNDGQF 1238
Cdd:pfam13385    2 GGSDYVTLPDALLPTSDFtVSAWVKPDSLPGwarAIISSSGGGGYSLGLDGdGRLRFAVNGGNGGWDTVTSGASVPLGQW 81

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1387231811 1239 HSVELVMLNQTLNLVVDkGAPKSLGKLQKQPAVSINSPLYLGGiptstglsalRQGMDRPlggFHGCIHEVRI 1311
Cdd:pfam13385   82 THVAVTYDGGTLRLYVN-GVLVGSSTLTGGPPPGTGGPLYIGR----------SPGGDDY---FNGLIDEVRI 140
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 280-306 6.40e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 38.38  E-value: 6.40e-04
                           10        20
                   ....*....|....*....|....*..
gi 1387231811  280 CPSACTCSNNIVDCRGKGLTEIPANLP 306
Cdd:pfam01462    2 CPVPCHCSATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
505-535 1.02e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 38.07  E-value: 1.02e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1387231811   505 CPDRCRCEGTIVDCSNQKLARIPSHLPEYVT 535
Cdd:smart00013    2 CPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 755-839 1.08e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.08  E-value: 1.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  755 TELYLEGNHLTavPKELSSF---------RHLTLIDLSNNSIGMLTNytFSNMSHLSTLILSYNRLRCIP--VHSFNGLR 823
Cdd:cd21340     93 EELHIENQRLP--PGEKLTFdprslaalsNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWP 168

                           90
                   ....*....|....*.
gi 1387231811  824 SLRVLTLHGNDISSVP 839
Cdd:cd21340    169 SLRELDLTGNPVCKKP 184
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 62-180 1.45e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.30  E-value: 1.45e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   62 NAERLDLDRNNITRITKTDFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSNLKLTRLDLS 141
Cdd:PLN00113   476 RLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLS 555

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1387231811  142 ENQILGIPRKAFRGIADVKNLQLDNNHI--SCIEDGAFRAL 180
Cdd:PLN00113   556 QNQLSGEIPKNLGNVESLVQVNISHNHLhgSLPSTGAFLAI 596
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1001-1029 2.00e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.00e-03
                           10        20
                   ....*....|....*....|....*....
gi 1387231811 1001 EDNDCENNATCVDGVNNYVCVCPPNYTGE 1029
Cdd:cd00053      4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 64-217 2.35e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 42.08  E-value: 2.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811   64 ERLDLDRNNI-----TRITKTDFAGlKNLRVLHLEDNQVSviERGA------FQDLKQLERLRLNKNK-----LQVLPEL 127
Cdd:COG5238    183 ETVYLGCNQIgdegiEELAEALTQN-TTVTTLWLKRNPIG--DEGAeilaeaLKGNKSLTTLDLSNNQigdegVIALAEA 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  128 LfQSNLKLTRLDLSENQI-------LGiprKAFRGIADVKNLQLDNNHISciEDGAfRALRD-------LEILTLNNNNI 193
Cdd:COG5238    260 L-KNNTTVETLYLSGNQIgaegaiaLA---KALQGNTTLTSLDLSVNRIG--DEGA-IALAEglqgnktLHTLNLAYNGI 332

                          170       180
                   ....*....|....*....|....*...
gi 1387231811  194 S----RILVTSFNHMPKIRTLRLHSNHL 217
Cdd:COG5238    333 GaqgaIALAKALQENTTLHSLDLSDNQI 360
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 959-992 2.75e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1387231811  959 CIQNPCLHGGTCHlseTHKGGFSCSCPLGFEGQR 992
Cdd:pfam00008    1 CAPNPCSNGGTCV---DTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1045-1069 2.78e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 2.78e-03
                           10        20
                   ....*....|....*....|....*
gi 1387231811 1045 CQHEAKCISLDRGFRCECPPGYSGK 1069
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGK 30
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
 1005-1024 2.93e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 36.54  E-value: 2.93e-03
                           10        20
                   ....*....|....*....|
gi 1387231811 1005 CENNATCVDGVNNYVCVCPP 1024
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPP 20
LRR smart00370
Leucine-rich repeats, outliers;
556-579 3.71e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 3.71e-03
                            10        20
                    ....*....|....*....|....
gi 1387231811   556 LPNLRKINLSNNRIKEVKEGAFDG 579
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
556-579 3.71e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 36.18  E-value: 3.71e-03
                            10        20
                    ....*....|....*....|....
gi 1387231811   556 LPNLRKINLSNNRIKEVKEGAFDG 579
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 1466-1519 4.43e-03

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 37.77  E-value: 4.43e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1387231811  1466 SCATASKIPVMECRGGCgpQCCQPTRSKRRKYVFQCTDGSSFVEELERHLECGC 1519
Cdd:smart00041   26 KCGSASSYSIQDVQHSC--SCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGC 77
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 85-121 4.89e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 4.89e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387231811   85 KNLRVLHLEDNQVSVIErgAFQDLKQLERLRLNKNKL 121
Cdd:pfam12799    1 PNLEVLDLSNNQITDIP--PLAKLPNLETLDLSGNNK 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 918-953 5.58e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 5.58e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387231811  918 DPCLS-SPCKNNGTCsQDPVEGHRCACSHGYKGRDCT 953
Cdd:cd00054      3 DECASgNPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 920-951 5.58e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 5.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1387231811  920 CLSSPCKNNGTCSQDPvEGHRCACSHGYKGRD 951
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
LRR smart00370
Leucine-rich repeats, outliers;
822-845 5.94e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 5.94e-03
                            10        20
                    ....*....|....*....|....
gi 1387231811   822 LRSLRVLTLHGNDISSVPEGSFND 845
Cdd:smart00370    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
822-845 5.94e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.41  E-value: 5.94e-03
                            10        20
                    ....*....|....*....|....
gi 1387231811   822 LRSLRVLTLHGNDISSVPEGSFND 845
Cdd:smart00369    1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 537-574 6.91e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 6.91e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1387231811  537 LRLNDNEISVLEAtgiFKKLPNLRKINLS-NNRIKEVKE 574
Cdd:pfam12799    6 LDLSNNQITDIPP---LAKLPNLETLDLSgNNKITDLSD 41
EGF_CA smart00179
Calcium-binding EGF-like domain;
962-994 7.18e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.69  E-value: 7.18e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1387231811   962 NPCLHGGTCHLSEthkGGFSCSCPLGFE-GQRCE 994
Cdd:smart00179    9 NPCQNGGTCVNTV---GSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1043-1072 8.25e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.53  E-value: 8.25e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1387231811 1043 NLCQHEAKCISLDRGFRCECPPGYSG-KLCE 1072
Cdd:cd00053      6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 777-857 8.63e-03

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 37.91  E-value: 8.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  777 LTLIDLSNN--SIGmltNYTFSNMSHLSTLILSYNrLRCIPVHSFNGLrSLRVLTLHGNdISSVPEGSFNDLTSLSHLAL 854
Cdd:pfam13306   13 LTSITIPSSltSIG---EYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIPSS-LTSIGEYAFSNCSNLKSITL 86


                   ...
gi 1387231811  855 GTN 857
Cdd:pfam13306   87 PSN 89
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 741-869 9.54e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.03  E-value: 9.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  741 RGLRALPKGI---PKDVTELYLEGNHLTAVP-----KELSSFRHLTLIDLSNNSIGM-LTNYTFSNM---SHLSTLILSY 808
Cdd:cd00116    123 RGLRLLAKGLkdlPPALEKLVLGRNRLEGAScealaKALRANRDLKELNLANNGIGDaGIRALAEGLkanCNLEVLDLNN 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387231811  809 NRLRCIPV----HSFNGLRSLRVLTLHGNDISSVP-----EGSFNDLTSLSHLALGTNPLHCD------------CSLRW 867
Cdd:cd00116    203 NGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAGaaalaSALLSPNISLLTLSLSCNDITDDgakdlaevlaekESLLE 282


                   ..
gi 1387231811  868 LS 869
Cdd:cd00116    283 LD 284
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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