NCBI Conserved Domain Search

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

163-203

3.79e-13

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif after the most conserved region of the repeat. The YWTD repeat is found in multiple tandem repeats and has been predicted to form a beta-propeller structure.

Pssm-ID: 459654 Cd Length: 42 Bit Score: 64.87 E-value: 3.79e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  163 GYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTID 203
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

408-450

2.31e-12

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. Also present in a variety of molecules similar to gp300/megalin.

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 62.62 E-value: 2.31e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   408 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 450
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

299-336

1.55e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 60.33 E-value: 1.55e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387253649  299 CEEDNGGCSHLCLLSPRepFYACACPTGVQLQDNGQTC 336
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1335-1369

1.71e-11

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.91 E-value: 1.71e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1335 CLPNQFRCASGQCVLIKQQCDSFPDCVDGSDELMC 1369
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

906-941

1.83e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 59.95 E-value: 1.83e-11

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1387253649  906 CMHNNGQCGQLCLAVPSGHRCSCASHYTLDPSSRNC 941
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1257-1294

1.86e-11

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 59.95 E-value: 1.86e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387253649 1257 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1294
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1297-1331

2.24e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.91 E-value: 2.24e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1297 CSASQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1331
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

495-537

2.91e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.54 E-value: 2.91e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   495 HILVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVIDVDGTKR 537
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

710-752

7.00e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 7.00e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   710 EHVIEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 752
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

471-511

9.09e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 58.33 E-value: 9.09e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  471 GLMYWTDWGENPKIECANLDGQERHILVNTSLGWPNGLALD 511
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

102-142

2.75e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 56.84 E-value: 2.75e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   102 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

187-229

2.83e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 56.84 E-value: 2.83e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   187 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 229
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

648-782

8.20e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 58.17 E-value: 8.20e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  648 VFTSRAAIHRIS-LDTNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGlDYPEGMAVD 726
Cdd:COG3391     82 LYVANSGSGRVSvIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVD 160

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387253649  727 WMGKNLYWADTGTNRIE--VARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWTEWGG 782
Cdd:COG3391    161 PDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRGS 219

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

605-640

1.84e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 51.47 E-value: 1.84e-08

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1387253649  605 CADRNGGCSHLCFFTPRATKCGCPIGLELLSDMKTC 640
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

28-214

1.57e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.31 E-value: 1.57e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649   28 PAAASPLLLFANRRDVRLVDAGGVKVESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQNVV 103
Cdd:COG3391     29 GLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVVATI 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  104 ISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER--AG 180
Cdd:COG3391    107 PVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSV 182

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1387253649  181 MDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 214
Cdd:COG3391    183 IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

366-406

2.76e-07

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 48.37 E-value: 2.76e-07

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   366 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 406
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

1216-1252

1.28e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.47 E-value: 1.28e-06

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387253649 1216 CARDNGGCSHICVAkGDGTPRCSCPVHLVLLQNLLTC 1252
Cdd:pfam14670    1 CSVNNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1104-1146

1.31e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 46.44 E-value: 1.31e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649  1104 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1146
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

799-838

3.24e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.29 E-value: 3.24e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1387253649   799 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 838
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

838-879

1.22e-05

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 43.74 E-value: 1.22e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649   838 RVVIADDLPHPFGLT--QYSDYIYWTDWNLHSIERADKTsGRNR 879
Cdd:smart00135    1 RTLLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

538-571

3.34e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.51 E-value: 3.34e-04

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1387253649   538 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 571
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

970-1009

6.15e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 38.74 E-value: 6.15e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   970 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1009
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1060-1103

7.15e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 36.04 E-value: 7.15e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649  1060 MVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1103
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

230-264

9.90e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 35.66 E-value: 9.90e-03

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1387253649   230 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 264
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Name

Accession

Description

Interval

E-value

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

163-203

3.79e-13

Pssm-ID: 459654 Cd Length: 42 Bit Score: 64.87 E-value: 3.79e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  163 GYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTID 203
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

408-450

2.31e-12

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 62.62 E-value: 2.31e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   408 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 450
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

299-336

1.55e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 60.33 E-value: 1.55e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387253649  299 CEEDNGGCSHLCLLSPRepFYACACPTGVQLQDNGQTC 336
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1335-1369

1.71e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.91 E-value: 1.71e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1335 CLPNQFRCASGQCVLIKQQCDSFPDCVDGSDELMC 1369
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

906-941

1.83e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 59.95 E-value: 1.83e-11

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1387253649  906 CMHNNGQCGQLCLAVPSGHRCSCASHYTLDPSSRNC 941
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1257-1294

1.86e-11

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 59.95 E-value: 1.86e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387253649 1257 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1294
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1297-1331

2.24e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.91 E-value: 2.24e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1297 CSASQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1331
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

495-537

2.91e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.54 E-value: 2.91e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   495 HILVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVIDVDGTKR 537
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1258-1294

4.67e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 58.76 E-value: 4.67e-11

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387253649 1258 CSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1294
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

710-752

7.00e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 7.00e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   710 EHVIEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 752
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

471-511

9.09e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 58.33 E-value: 9.09e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  471 GLMYWTDWGENPKIECANLDGQERHILVNTSLGWPNGLALD 511
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

143-186

1.23e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.00 E-value: 1.23e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649   143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGeTPRIERAGMDGSTR 186
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

102-142

2.75e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 56.84 E-value: 2.75e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   102 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

451-494

2.78e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 56.84 E-value: 2.78e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649   451 KILVSEDLDEPRAIVLHPVMGLMYWTDWGeNPKIECANLDGQER 494
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

187-229

2.83e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 56.84 E-value: 2.83e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   187 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 229
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1257-1291

4.61e-10

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.

Pssm-ID: 197566 Cd Length: 33 Bit Score: 56.10 E-value: 4.61e-10

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1387253649  1257 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 1291
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1297-1331

1.47e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 54.56 E-value: 1.47e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1297 CSASQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1331
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1335-1366

1.61e-09

Pssm-ID: 197566 Cd Length: 33 Bit Score: 54.56 E-value: 1.61e-09

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1387253649  1335 CLPNQFRCASGQCVLIKQQCDSFPDCVDGSDE 1366
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

121-160

2.71e-09

Pssm-ID: 459654 Cd Length: 42 Bit Score: 54.09 E-value: 2.71e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  121 KLYWTDSET-NRIEVANLNGTSRKVLFWQDLDQPRAIALDP 160
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1335-1369

6.70e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 52.64 E-value: 6.70e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1335 CLPNQFRCASGQCVLIKQQCDSFPDCVDGSDELMC 1369
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

648-782

8.20e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 58.17 E-value: 8.20e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  648 VFTSRAAIHRIS-LDTNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGlDYPEGMAVD 726
Cdd:COG3391     82 LYVANSGSGRVSvIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVD 160

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387253649  727 WMGKNLYWADTGTNRIE--VARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWTEWGG 782
Cdd:COG3391    161 PDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRGS 219

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1297-1328

9.18e-09

Pssm-ID: 197566 Cd Length: 33 Bit Score: 52.25 E-value: 9.18e-09

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1387253649  1297 CSASQFPCARGQCVDLRLRCDGEADCQDRSDE 1328
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

605-640

1.84e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 51.47 E-value: 1.84e-08

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1387253649  605 CADRNGGCSHLCFFTPRATKCGCPIGLELLSDMKTC 640
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

428-468

3.92e-08

Pssm-ID: 459654 Cd Length: 42 Bit Score: 50.62 E-value: 3.92e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387253649  428 RNLYWTDTGTD-RIEVTRLNGTSRKILVSEDLDEPRAIVLHP 468
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

753-796

9.49e-08

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 49.52 E-value: 9.49e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649   753 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 796
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

28-214

1.57e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.31 E-value: 1.57e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649   28 PAAASPLLLFANRRDVRLVDAGGVKVESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQNVV 103
Cdd:COG3391     29 GLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVVATI 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  104 ISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER--AG 180
Cdd:COG3391    107 PVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSV 182

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1387253649  181 MDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 214
Cdd:COG3391    183 IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

685-878

2.68e-07

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 53.86 E-value: 2.68e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  685 SNNHIYWTDVSLKTISRaFmnGSSVEHVIEFG--------LDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV 756
Cdd:cd05819     17 SSGNIYVADTGNNRIQV-F--DPDGNFITSFGsfgsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFG 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  757 -----WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLD 824
Cdd:cd05819     93 gsgdgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTG 168

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387253649  825 TNMIE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 878
Cdd:cd05819    169 NHRIQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

366-406

2.76e-07

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 48.37 E-value: 2.76e-07

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   366 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 406
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

349-562

5.34e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 52.77 E-value: 5.34e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  349 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVAR 428
Cdd:COG3391      1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  429 NLYWTDTGTDRIEVtrLNGTSRKILVSEDL-DEPRAIVLHPVMGLMYWTDWGENpKIecANLDGQERHILVNTSLG-WPN 506
Cdd:COG3391     81 RLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVGaGPH 155

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387253649  507 GLALDLQEGKLYWGDAKTDKI----EVIDV-DGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 562
Cdd:COG3391    156 GIAVDPDGKRLYVANSGSNTVsvivSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

1216-1252

1.28e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.47 E-value: 1.28e-06

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387253649 1216 CARDNGGCSHICVAkGDGTPRCSCPVHLVLLQNLLTC 1252
Cdd:pfam14670    1 CSVNNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1104-1146

1.31e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 46.44 E-value: 1.31e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649  1104 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1146
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

37-169

1.62e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 51.05 E-value: 1.62e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649   37 FANRRDVRLvdAGGVKVESTIVVSGLEDAA--AVDFQfskGAVYWTD-VSEEAIKQtylnQTGAAVQNVV-ISGLVSPDG 112
Cdd:cd14952     70 FGNNRVLKL--AAGSTTQTVLPFTGLNDPTgvAVDAA---GNVYVADtGNNRVLKL----AAGSNTQTVLpFTGLSNPDG 140

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387253649  113 LACDWVGKkLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTD 169
Cdd:cd14952    141 VAVDGAGN-VYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA-GNVYVTD 195

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

799-838

3.24e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.29 E-value: 3.24e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1387253649   799 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 838
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

374-535

3.27e-06

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 50.39 E-value: 3.27e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  374 HAIAIDYDpleGYVYWTDDEVRAIRR-----AYLDGSGAQTLVNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 448
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  449 SRKIL-----VSEDLDEPRAIVLHPVmGLMYWTDWGENpKIECANLDGQE-----RHILVNTSLGWPNGLALDlQEGKLY 518
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH-RIQVFDPDGNFlttfgSTGTGPGQFNYPTGIAVD-SDGNIY 210

                          170
                   ....*....|....*..
gi 1387253649  519 WGDAKTDKIEVIDVDGT 535
Cdd:cd05819    211 VADSGNNRVQVFDPDGA 227

C_rich_MXAN6577

NF041328

MXAN_6577-like cysteine-rich domain;

1252-1347

3.73e-06

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 48.22 E-value: 3.73e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649 1252 CGEppTCSPDQfACATGEIDCIPGAWRCDGfpEC-DDQSDEEGCPVCSASQFP---CARGQCVDL----RLRCDGEadCQ 1323
Cdd:NF041328    45 CGV--ACGAGQ-TCVAGACGCGPGTVACGG--ACvDTASDPAHCGACGAACAPgqvCEGGACREAcsegLTRCGGA--CV 117

                           90       100
                   ....*....|....*....|....*...
gi 1387253649 1324 D-RSDEAD---CDAVCLPNQFrCASGQC 1347
Cdd:NF041328   118 DlATDPLHcgaCGVACDPGES-CRGGAC 144

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

838-879

1.22e-05

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 43.74 E-value: 1.22e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649   838 RVVIADDLPHPFGLT--QYSDYIYWTDWNLHSIERADKTsGRNR 879
Cdd:smart00135    1 RTLLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

687-727

2.04e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 42.92 E-value: 2.04e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387253649  687 NHIYWTDVSLK-TISRAFMNGSSVEHVIEFGLDYPEGMAVDW 727
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

385-425

2.41e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 42.92 E-value: 2.41e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387253649  385 GYVYWTDDEVRA-IRRAYLDGSGAQTLVNTEINDPDGIAVDW 425
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

716-776

3.83e-05

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.20 E-value: 3.83e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1387253649  716 GLDYPEGMAVDWMGkNLYWADTGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDPTkGYIY 776
Cdd:cd14952      8 GLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVY 66

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

731-770

1.27e-04

Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.99 E-value: 1.27e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  731 NLYWADTGT-NRIEVARLDGQFRQVLVWRDLDNPRSLALDP 770
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

538-571

3.34e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.51 E-value: 3.34e-04

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1387253649   538 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 571
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

970-1009

6.15e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 38.74 E-value: 6.15e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   970 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1009
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

515-553

3.11e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 36.75 E-value: 3.11e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1387253649  515 GKLYWGDAKTD-KIEVIDVDGTKRRTLLEDKLPHIFGFTL 553
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAV 40

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1060-1103

7.15e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 36.04 E-value: 7.15e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649  1060 MVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1103
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

856-896

7.48e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.98 E-value: 7.48e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387253649  856 DYIYWTDWNLH-SIERADKTSGRNRTLIQGHLDFVMDILVFH 896
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

230-264

9.90e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 35.66 E-value: 9.90e-03

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1387253649   230 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 264
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

207-245

9.95e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.60 E-value: 9.95e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1387253649  207 QKLYWADAKLSF-IHRANLDGSFRQKVVEGSLTHPFALTL 245
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAV 40

Name

Accession

Description

Interval

E-value

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

163-203

3.79e-13

Pssm-ID: 459654 Cd Length: 42 Bit Score: 64.87 E-value: 3.79e-13

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  163 GYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTID 203
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

408-450

2.31e-12

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 62.62 E-value: 2.31e-12

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   408 QTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSR 450
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

299-336

1.55e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 60.33 E-value: 1.55e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387253649  299 CEEDNGGCSHLCLLSPRepFYACACPTGVQLQDNGQTC 336
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPG--GYTCSCPEGYELQDDGRTC 36

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1335-1369

1.71e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.91 E-value: 1.71e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1335 CLPNQFRCASGQCVLIKQQCDSFPDCVDGSDELMC 1369
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

906-941

1.83e-11

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 59.95 E-value: 1.83e-11

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1387253649  906 CMHNNGQCGQLCLAVPSGHRCSCASHYTLDPSSRNC 941
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1257-1294

1.86e-11

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 59.95 E-value: 1.86e-11

                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1387253649 1257 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1294
Cdd:pfam00057    2 TCSPNEFQCGSGE--CIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1297-1331

2.24e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 59.91 E-value: 2.24e-11

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1297 CSASQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1331
Cdd:cd00112      1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

495-537

2.91e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 59.54 E-value: 2.91e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   495 HILVNTSLGWPNGLALDLQEGKLYWGDAKTDKIEVIDVDGTKR 537
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

LDLa

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...

1258-1294

4.67e-11

Pssm-ID: 238060 Cd Length: 35 Bit Score: 58.76 E-value: 4.67e-11

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387253649 1258 CSPDQFACATGEidCIPGAWRCDGFPECDDQSDEEGC 1294
Cdd:cd00112      1 CPPNEFRCANGR--CIPSSWVCDGEDDCGDGSDEENC 35

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

710-752

7.00e-11

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.38 E-value: 7.00e-11

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   710 EHVIEFGLDYPEGMAVDWMGKNLYWADTGTNRIEVARLDGQFR 752
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

471-511

9.09e-11

Pssm-ID: 459654 Cd Length: 42 Bit Score: 58.33 E-value: 9.09e-11

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  471 GLMYWTDWGENPKIECANLDGQERHILVNTSLGWPNGLALD 511
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFTDDLQHPNAIAVD 41

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

143-186

1.23e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 58.00 E-value: 1.23e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649   143 KVLFWQDLDQPRAIALDPAHGYMYWTDWGeTPRIERAGMDGSTR 186
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

102-142

2.75e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 56.84 E-value: 2.75e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   102 VVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSR 142
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

451-494

2.78e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 56.84 E-value: 2.78e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649   451 KILVSEDLDEPRAIVLHPVMGLMYWTDWGeNPKIECANLDGQER 494
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWG-LDVIEVANLDGTNR 43

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

187-229

2.83e-10

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 56.84 E-value: 2.83e-10

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649   187 KIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSFR 229
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1257-1291

4.61e-10

Pssm-ID: 197566 Cd Length: 33 Bit Score: 56.10 E-value: 4.61e-10

                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1387253649  1257 TCSPDQFACATGEidCIPGAWRCDGFPECDDQSDE 1291
Cdd:smart00192    1 TCPPGEFQCDNGR--CIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1297-1331

1.47e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 54.56 E-value: 1.47e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1297 CSASQFPCARGQCVDLRLRCDGEADCQDRSDEADC 1331
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1335-1366

1.61e-09

Pssm-ID: 197566 Cd Length: 33 Bit Score: 54.56 E-value: 1.61e-09

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1387253649  1335 CLPNQFRCASGQCVLIKQQCDSFPDCVDGSDE 1366
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

121-160

2.71e-09

Pssm-ID: 459654 Cd Length: 42 Bit Score: 54.09 E-value: 2.71e-09

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  121 KLYWTDSET-NRIEVANLNGTSRKVLFWQDLDQPRAIALDP 160
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Ldl_recept_a

Low-density lipoprotein receptor domain class A;

1335-1369

6.70e-09

Low-density lipoprotein receptor domain class A;

Pssm-ID: 395011 Cd Length: 37 Bit Score: 52.64 E-value: 6.70e-09

                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1387253649 1335 CLPNQFRCASGQCVLIKQQCDSFPDCVDGSDELMC 1369
Cdd:pfam00057    3 CSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

648-782

8.20e-09

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 58.17 E-value: 8.20e-09

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  648 VFTSRAAIHRIS-LDTNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVIEFGlDYPEGMAVD 726
Cdd:COG3391     82 LYVANSGSGRVSvIDLATGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVG-AGPHGIAVD 160

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387253649  727 WMGKNLYWADTGTNRIE--VARLDGQFRQVL-VWRDLDNPRSLALDPTKGYIYWTEWGG 782
Cdd:COG3391    161 PDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRGS 219

LDLa

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...

1297-1328

9.18e-09

Pssm-ID: 197566 Cd Length: 33 Bit Score: 52.25 E-value: 9.18e-09

                            10        20        30
                    ....*....|....*....|....*....|..
gi 1387253649  1297 CSASQFPCARGQCVDLRLRCDGEADCQDRSDE 1328
Cdd:smart00192    2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

605-640

1.84e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 51.47 E-value: 1.84e-08

                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1387253649  605 CADRNGGCSHLCFFTPRATKCGCPIGLELLSDMKTC 640
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

428-468

3.92e-08

Pssm-ID: 459654 Cd Length: 42 Bit Score: 50.62 E-value: 3.92e-08

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387253649  428 RNLYWTDTGTD-RIEVTRLNGTSRKILVSEDLDEPRAIVLHP 468
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

753-796

9.49e-08

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 49.52 E-value: 9.49e-08

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649   753 QVLVWRDLDNPRSLALDPTKGYIYWTEWgGKPRIVRAFMDGTNC 796
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDW-GLDVIEVANLDGTNR 43

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

28-214

1.57e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 54.31 E-value: 1.57e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649   28 PAAASPLLLFANRRDVRLVDAGGVKVESTIVVSGLEDAAAVDFQFSKGA----VYWTDVSEEAIkqTYLNQTGAAVQNVV 103
Cdd:COG3391     29 GLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGAdgrrLYVANSGSGRV--SVIDLATGKVVATI 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  104 ISGlVSPDGLACDWVGKKLYWTDSETNRIEVanLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWGeTPRIER--AG 180
Cdd:COG3391    107 PVG-GGPRGLAVDPDGGRLYVADSGNGRVSV--IDTATGKVVaTIPVGAGPHGIAVDPDGKRLYVANSG-SNTVSVivSV 182

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1387253649  181 MDGSTRKII--VDSDIYwPNGLTIDLEEQKLYWADA 214
Cdd:COG3391    183 IDTATGKVVatIPVGGG-PVGVAVSPDGRRLYVANR 217

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

685-878

2.68e-07

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 53.86 E-value: 2.68e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  685 SNNHIYWTDVSLKTISRaFmnGSSVEHVIEFG--------LDYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQFRQVLV 756
Cdd:cd05819     17 SSGNIYVADTGNNRIQV-F--DPDGNFITSFGsfgsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNFLASFG 92

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  757 -----WRDLDNPRSLALDPtKGYIYWTEWGGKpRIVRaFMDGTNCMTLVDKVGRAN-------DLTIDyADQRLYWTDLD 824
Cdd:cd05819     93 gsgdgDGEFNGPRGIAVDS-SGNIYVADTGNH-RIQK-FDPDGEFLTTFGSGGSGPgqfngptGVAVD-SDGNIYVADTG 168

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387253649  825 TNMIE----SSNML---GQERVVIAdDLPHPFGLT-QYSDYIYWTDWNLHSIERADKTSGRN 878
Cdd:cd05819    169 NHRIQvfdpDGNFLttfGSTGTGPG-QFNYPTGIAvDSDGNIYVADSGNNRVQVFDPDGAGF 229

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

366-406

2.76e-07

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 48.37 E-value: 2.76e-07

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   366 VLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSG 406
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTN 42

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

349-562

5.34e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 52.77 E-value: 5.34e-07

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  349 RTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEINDPDGIAVDWVAR 428
Cdd:COG3391      1 ALVASSLLVAVLLAVLALAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGR 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  429 NLYWTDTGTDRIEVtrLNGTSRKILVSEDL-DEPRAIVLHPVMGLMYWTDWGENpKIecANLDGQERHILVNTSLG-WPN 506
Cdd:COG3391     81 RLYVANSGSGRVSV--IDLATGKVVATIPVgGGPRGLAVDPDGGRLYVADSGNG-RV--SVIDTATGKVVATIPVGaGPH 155

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387253649  507 GLALDLQEGKLYWGDAKTDKI----EVIDV-DGTKRRTLLEDKLPHIFGFTLLGDFIYWTD 562
Cdd:COG3391    156 GIAVDPDGKRLYVANSGSNTVsvivSVIDTaTGKVVATIPVGGGPVGVAVSPDGRRLYVAN 216

FXa_inhibition

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...

1216-1252

1.28e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 46.47 E-value: 1.28e-06

                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1387253649 1216 CARDNGGCSHICVAkGDGTPRCSCPVHLVLLQNLLTC 1252
Cdd:pfam14670    1 CSVNNGGCSHLCLN-TPGGYTCSCPEGYELQDDGRTC 36

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1104-1146

1.31e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 46.44 E-value: 1.31e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1387253649  1104 EVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESCDLSGANR 1146
Cdd:smart00135    1 RTLLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

37-169

1.62e-06

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 51.05 E-value: 1.62e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649   37 FANRRDVRLvdAGGVKVESTIVVSGLEDAA--AVDFQfskGAVYWTD-VSEEAIKQtylnQTGAAVQNVV-ISGLVSPDG 112
Cdd:cd14952     70 FGNNRVLKL--AAGSTTQTVLPFTGLNDPTgvAVDAA---GNVYVADtGNNRVLKL----AAGSNTQTVLpFTGLSNPDG 140

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1387253649  113 LACDWVGKkLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTD 169
Cdd:cd14952    141 VAVDGAGN-VYVTDTGNNRVLKLAAGSTTQTVLPFTGLNSPSGVAVDTA-GNVYVTD 195

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

799-838

3.24e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 45.29 E-value: 3.24e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1387253649   799 LVDKVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQER 838
Cdd:smart00135    4 LSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

374-535

3.27e-06

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 50.39 E-value: 3.27e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  374 HAIAIDYDpleGYVYWTDDEVRAIRR-----AYLDGSGAQTLVNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT 448
Cdd:cd05819     58 AGVAVDSD---GNLYVADTGNHRIQKfdpdgNFLASFGGSGDGDGEFNGPRGIAVD-SSGNIYVADTGNHRIQKFDPDGE 133

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  449 SRKIL-----VSEDLDEPRAIVLHPVmGLMYWTDWGENpKIECANLDGQE-----RHILVNTSLGWPNGLALDlQEGKLY 518
Cdd:cd05819    134 FLTTFgsggsGPGQFNGPTGVAVDSD-GNIYVADTGNH-RIQVFDPDGNFlttfgSTGTGPGQFNYPTGIAVD-SDGNIY 210

                          170
                   ....*....|....*..
gi 1387253649  519 WGDAKTDKIEVIDVDGT 535
Cdd:cd05819    211 VADSGNNRVQVFDPDGA 227

C_rich_MXAN6577

NF041328

MXAN_6577-like cysteine-rich domain;

1252-1347

3.73e-06

MXAN_6577-like cysteine-rich domain;

Pssm-ID: 469225 [Multi-domain] Cd Length: 145 Bit Score: 48.22 E-value: 3.73e-06

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649 1252 CGEppTCSPDQfACATGEIDCIPGAWRCDGfpEC-DDQSDEEGCPVCSASQFP---CARGQCVDL----RLRCDGEadCQ 1323
Cdd:NF041328    45 CGV--ACGAGQ-TCVAGACGCGPGTVACGG--ACvDTASDPAHCGACGAACAPgqvCEGGACREAcsegLTRCGGA--CV 117

                           90       100
                   ....*....|....*....|....*...
gi 1387253649 1324 D-RSDEAD---CDAVCLPNQFrCASGQC 1347
Cdd:NF041328   118 DlATDPLHcgaCGVACDPGES-CRGGAC 144

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

669-709

6.56e-06

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 44.51 E-value: 6.56e-06

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   669 IPLTGVKEASALDFDVSNNHIYWTDVSLKTISRAFMNGSSV 709
Cdd:smart00135    3 LLSSGLGHPNGLAVDWIEGRLYWTDWGLDVIEVANLDGTNR 43

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

416-539

1.02e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 49.21 E-value: 1.02e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  416 NDPDGIAVDWvaRNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDE-----PRAIVLHPvMGLMYWTDWGeNPKIECANLD 490
Cdd:cd14963     10 NKPMGVAVSD--GRIYVADTNNHRVQVFDYEGKFKKSFGGPGTGPgefkyPYGIAVDS-DGNIYVADLY-NGRIQVFDPD 85

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1387253649  491 GQERHILVNTS----LGWPNGLALDlqEGKLYWGDAKTDKIEVIDVDGTKRRT 539
Cdd:cd14963     86 GKFLKYFPEKKdrvkLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLE 136

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

838-879

1.22e-05

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 43.74 E-value: 1.22e-05

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649   838 RVVIADDLPHPFGLT--QYSDYIYWTDWNLHSIERADKTsGRNR 879
Cdd:smart00135    1 RTLLSSGLGHPNGLAvdWIEGRLYWTDWGLDVIEVANLD-GTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

687-727

2.04e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 42.92 E-value: 2.04e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387253649  687 NHIYWTDVSLK-TISRAFMNGSSVEHVIEFGLDYPEGMAVDW 727
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

337-534

2.12e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 47.77 E-value: 2.12e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  337 KAGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGSGAQTL--VNTE 414
Cdd:COG3391     19 AALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVsvIDLA 98

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  415 IN----------DPDGIAVDWVARNLYWTDTGTDRieVTRLNGTSRKILVSEDL-DEPRAIVLHPVMGLMYWTDWGENpK 483
Cdd:COG3391     99 TGkvvatipvggGPRGLAVDPDGGRLYVADSGNGR--VSVIDTATGKVVATIPVgAGPHGIAVDPDGKRLYVANSGSN-T 175

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387253649  484 IEC--ANLDGQERHILVNTSLG-WPNGLALDLQEGKLY-------WGDAKTDKIEVIDVDG 534
Cdd:COG3391    176 VSVivSVIDTATGKVVATIPVGgGPVGVAVSPDGRRLYvanrgsnTSNGGSNTVSVIDLAT 236

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

385-425

2.41e-05

Pssm-ID: 459654 Cd Length: 42 Bit Score: 42.92 E-value: 2.41e-05

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387253649  385 GYVYWTDDEVRA-IRRAYLDGSGAQTLVNTEINDPDGIAVDW 425
Cdd:pfam00058    1 GRLYWTDSSLRAsISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

683-828

2.73e-05

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 47.67 E-value: 2.73e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  683 DVSNNHIYWTDVSLKTISRAFMNGssvEHVIEFG--------LDYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFRQV 754
Cdd:cd14963    108 AIDDGKLYVSDVKKHKVIVFDLEG---KLLLEFGkpgsepgeLSYPNGIAVDEDG-NIYVADSGNGRIQVFDKNGKFIKE 183

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  755 LVWRDLD-----NPRSLALDPtKGYIY-----------WTEWGGKPRIVRAFMDGTNCMTLvdkvgrANDLTIDyADQRL 818
Cdd:cd14963    184 LNGSPDGksgfvNPRGIAVDP-DGNLYvvdnlshrvyvFDEQGKELFTFGGRGKDDGQFNL------PNGLFID-DDGRL 255

                          170
                   ....*....|
gi 1387253649  819 YWTDLDTNMI 828
Cdd:cd14963    256 YVTDRENNRV 265

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

716-776

3.83e-05

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 47.20 E-value: 3.83e-05

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1387253649  716 GLDYPEGMAVDWMGkNLYWADTGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDPTkGYIY 776
Cdd:cd14952      8 GLDGPGGVAVDAAG-NVYVADSGNNR--VLKLAaGSTTQtVLPFTGLYQPQGVAVDAA-GTVY 66

Vgb

COG4257

Streptogramin lyase [Defense mechanisms];

654-828

5.06e-05

Streptogramin lyase [Defense mechanisms];

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 46.94 E-value: 5.06e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  654 AIHRISLDTNNND-VAIPlTGVKEASALDFDvSNNHIYWTDVSLKTISR---AfmNGSSVEHVIEFGLDYPEGMAVDWMG 729
Cdd:COG4257     81 RIGRIDPKTGEITtFALP-GGGSNPHGIAFD-PDGNLWFTDQGGNRIGRldpA--TGEVTEFPLPTGGAGPYGIAVDPDG 156

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  730 kNLYWADTGTNRIevARLD---GQFRQVLVWRDLDNPRSLALDPtKGYIYWTEWGGkpRIVRAFMDGTNCMT---LVDKV 803
Cdd:COG4257    157 -NLWVTDFGANAI--GRIDpdtGTLTEYALPTPGAGPRGLAVDP-DGNLWVADTGS--GRIGRFDPKTGTVTeypLPGGG 230

                          170       180
                   ....*....|....*....|....*
gi 1387253649  804 GRANDLTIDYADqRLYWTDLDTNMI 828
Cdd:COG4257    231 ARPYGVAVDGDG-RVWFAESGANRI 254

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

729-828

5.19e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 46.61 E-value: 5.19e-05

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  729 GKNLYWADTGTNRIEVARLDgQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKpRIVRafMDGTNcMTLVDKV---GR 805
Cdd:COG3391     79 GRRLYVANSGSGRVSVIDLA-TGKVVATIPVGGGPRGLAVDPDGGRLYVADSGNG-RVSV--IDTAT-GKVVATIpvgAG 153

                           90       100
                   ....*....|....*....|...
gi 1387253649  806 ANDLTIDYADQRLYWTDLDTNMI 828
Cdd:COG3391    154 PHGIAVDPDGKRLYVANSGSNTV 176

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

35-171

1.05e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 45.46 E-value: 1.05e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649   35 LLFANRRD--VRLVDAGGVKVESTIVVSGleDAAAVDFQFSKGAVYWTDVSEEAIkQTYLNQTGAAVQnvVISGLVSPDG 112
Cdd:COG3391     82 LYVANSGSgrVSVIDLATGKVVATIPVGG--GPRGLAVDPDGGRLYVADSGNGRV-SVIDTATGKVVA--TIPVGAGPHG 156

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387253649  113 LACDWVGKKLYWTDSETNRIE--VANLNGTSRKVL-FWQDLDQPRAIALDPAHGYMYWTDWG 171
Cdd:COG3391    157 IAVDPDGKRLYVANSGSNTVSviVSVIDTATGKVVaTIPVGGGPVGVAVSPDGRRLYVANRG 218

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

731-770

1.27e-04

Pssm-ID: 459654 Cd Length: 42 Bit Score: 40.99 E-value: 1.27e-04

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1387253649  731 NLYWADTGT-NRIEVARLDGQFRQVLVWRDLDNPRSLALDP 770
Cdd:pfam00058    2 RLYWTDSSLrASISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

664-788

1.59e-04

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 45.28 E-value: 1.59e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  664 NNDVAIPLTGVKEASALDFDVSNNhIYWTD------VSLKTisrafmnGSSVEHVIEF-GLDYPEGMAVDWMGkNLYWAD 736
Cdd:cd14952     83 TTQTVLPFTGLNDPTGVAVDAAGN-VYVADtgnnrvLKLAA-------GSNTQTVLPFtGLSNPDGVAVDGAG-NVYVTD 153

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1387253649  737 TGTNRieVARLD-GQFRQ-VLVWRDLDNPRSLALDpTKGYIYWTEwGGKPRIVR 788
Cdd:cd14952    154 TGNNR--VLKLAaGSTTQtVLPFTGLNSPSGVAVD-TAGNVYVTD-HGNNRVLK 203

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

718-870

1.61e-04

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 45.35 E-value: 1.61e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  718 DYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFrqVLVWRD-------LDNPRSLALDPtKGYIYWTEwGGKPRIVRAF 790
Cdd:cd14956    107 NAPRGVAVDADG-NLYVADFGNQRIQKFDPDGSF--LRQWGGtgiepgsFNYPRGVAVDP-DGTLYVAD-TYNDRIQVFD 181

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  791 MDGtncmTLVDKVGR----------ANDLTIDyADQRLYWTDLDTNMIESSNMLGQERVVI--ADDLPHPF----GLTQY 854
Cdd:cd14956    182 NDG----AFLRKWGGrgtgpgqfnyPYGIAID-PDGNVFVADFGNNRIQKFTADGTFLTSWgsPGTGPGQFknpwGVVVD 256

                          170
                   ....*....|....*..
gi 1387253649  855 SD-YIYWTDWNLHSIER 870
Cdd:cd14956    257 ADgTVYVADSNNNRVQR 273

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

407-568

2.54e-04

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 44.59 E-value: 2.54e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  407 AQTLVNTEINDPDGIAVDwvARNLYWTDTGTDRIEVTRLNGTSRKILVSE-----DLDEPRAIVLHPvMGLMYWTDWGeN 481
Cdd:cd14963     93 PEKKDRVKLISPAGLAID--DGKLYVSDVKKHKVIVFDLEGKLLLEFGKPgsepgELSYPNGIAVDE-DGNIYVADSG-N 168

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  482 PKIECANLDGQERHILVNTSLGW-----PNGLALDlQEGKLYWGDAKTDKIEVIDVDGTKRRTL----LED---KLPHif 549
Cdd:cd14963    169 GRIQVFDKNGKFIKELNGSPDGKsgfvnPRGIAVD-PDGNLYVVDNLSHRVYVFDEQGKELFTFggrgKDDgqfNLPN-- 245

                          170       180
                   ....*....|....*....|
gi 1387253649  550 GFTLLGD-FIYWTDWQRRSI 568
Cdd:cd14963    246 GLFIDDDgRLYVTDRENNRV 265

NHL_like_6

cd14962

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

376-534

2.96e-04

Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 44.50 E-value: 2.96e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  376 IAIDYDPlEGYVYWTDDEVRAIRRAYLDGSGAQTLVNT-EINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILV 454
Cdd:cd14962     60 IGVAIDA-NGNLYVSDAELGKVFVFDRDGKFLRAIGAGaLFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLLFDIG 138

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  455 S-----EDLDEPRAIVLHPvMGLMYWTDWGeNPKIECANLDGQERHIL--VNTSLGW---PNGLALDlQEGKLYWGDAKT 524
Cdd:cd14962    139 KrgsgpGEFNLPTDLAVDR-DGNLYVTDTM-NFRVQIFDADGKFLRSFgeRGDGPGSfarPKGIAVD-SEGNIYVVDAAF 215

                          170
                   ....*....|
gi 1387253649  525 DKIEVIDVDG 534
Cdd:cd14962    216 DNVQIFNPEG 225

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

75-264

3.14e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 44.50 E-value: 3.14e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649   75 GAVYWTDVSEEAIkQTYLNQTGAAVQNVVISGLVS-----PDG--LACDwVGKKLYWTDSETNRIEV-ANLNGTsrkvlf 146
Cdd:COG3386     19 GRLYWVDIPGGRI-HRYDPDGGAVEVFAEPSGRPNglafdPDGrlLVAD-HGRGLVRFDPADGEVTVlADEYGK------ 90

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  147 wqDLDQPRAIALDPaHGYMYWTD---WGETPRIERAGMDGSTRkiIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRAN 223
Cdd:COG3386     91 --PLNRPNDGVVDP-DGRLYFTDmgeYLPTGALYRVDPDGSLR--VLADGLTFPNGIAFSPDGRTLYVADTGAGRIYRFD 165

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1387253649  224 LDGSfrqkvveGSLTHP--FALTLSGD------------TLYWTDWQTRSIHACN 264
Cdd:COG3386    166 LDAD-------GTLGNRrvFADLPDGPggpdglavdadgNLWVALWGGGGVVRFD 213

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

538-571

3.34e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 39.51 E-value: 3.34e-04

                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1387253649   538 RTLLEDKLPHIFGFTL--LGDFIYWTDWQRRSIERV 571
Cdd:smart00135    1 RTLLSSGLGHPNGLAVdwIEGRLYWTDWGLDVIEVA 36

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

718-794

3.65e-04

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 44.20 E-value: 3.65e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  718 DYPEGMAVDwMGKNLYWADTGTNRIEVARLDGQF-RQvlVWR--DLDN----PRSLALDPtKGYIYWTE-WGGkpRIVRA 789
Cdd:cd14956     13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFlRR--FGTtgDGPGqfgrPRGLAVDK-DGWLYVADyWGD--RIQVF 86


                   ....*
gi 1387253649  790 FMDGT 794
Cdd:cd14956     87 TLTGE 91

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

661-770

4.60e-04

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 43.74 E-value: 4.60e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  661 DTNNNDV-----------AIPLTGVKEASALDFDVSNNhIYWTDVS----LKTISrafmnGSSVEHVIEF-GLDYPEGMA 724
Cdd:cd14952     27 DSGNNRVlklaagsttqtVLPFTGLYQPQGVAVDAAGT-VYVTDFGnnrvLKLAA-----GSTTQTVLPFtGLNDPTGVA 100

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1387253649  725 VDWMGkNLYWADTGTNRieVARLDGQ--FRQVLVWRDLDNPRSLALDP 770
Cdd:cd14952    101 VDAAG-NVYVADTGNNR--VLKLAAGsnTQTVLPFTGLSNPDGVAVDG 145

NHL_like_6

cd14962

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

103-254

4.70e-04

Pssm-ID: 271332 [Multi-domain] Cd Length: 271 Bit Score: 43.73 E-value: 4.70e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  103 VISGLVSPDGLACDWVGKkLYWTDSETNRIEVANLNgtSRKVLFW-----QDLDQPRAIALDPAhGYMYWTDwGETPRIE 177
Cdd:cd14962      7 PKEALTRPYGVAADGRGR-IYVADTGRGAVFVFDLP--NGKVFVIgnagpNRFVSPIGVAIDAN-GNLYVSD-AELGKVF 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  178 RAGMDGS-TRKIIVDSDIYWPNGLTIDLEEQKLYWADAKLSFIHRANLDGSF-----RQKVVEGSLTHPFALTLSGD-TL 250
Cdd:cd14962     82 VFDRDGKfLRAIGAGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVFDLDGRLlfdigKRGSGPGEFNLPTDLAVDRDgNL 161


                   ....
gi 1387253649  251 YWTD 254
Cdd:cd14962    162 YVTD 165

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

414-530

5.06e-04

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 43.82 E-value: 5.06e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  414 EINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDE-----PRAIVLHPvMGLMYWTDWGENpKIECAN 488
Cdd:cd14963    146 ELSYPNGIAVD-EDGNIYVADSGNGRIQVFDKNGKFIKELNGSPDGKsgfvnPRGIAVDP-DGNLYVVDNLSH-RVYVFD 222

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1387253649  489 LDGQERHIL-----VNTSLGWPNGLALDlQEGKLYWGDAKTDKIEVI 530
Cdd:cd14963    223 EQGKELFTFggrgkDDGQFNLPNGLFID-DDGRLYVTDRENNRVAVY 268

NHL_like_5

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

73-213

5.53e-04

Pssm-ID: 271333 [Multi-domain] Cd Length: 268 Bit Score: 43.82 E-value: 5.53e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649   73 SKGAVYWTDVSEEAIKqtYLNQTGAAVQNVVISG-----LVSPDGLACDWVGKkLYWTDSETNRIEVANLNGT-----SR 142
Cdd:cd14963    110 DDGKLYVSDVKKHKVI--VFDLEGKLLLEFGKPGsepgeLSYPNGIAVDEDGN-IYVADSGNGRIQVFDKNGKfikelNG 186

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387253649  143 KVLFWQDLDQPRAIALDPaHGYMYWTDwGETPRIERAGMDGSTRKII-----VDSDIYWPNGLTIDlEEQKLYWAD 213
Cdd:cd14963    187 SPDGKSGFVNPRGIAVDP-DGNLYVVD-NLSHRVYVFDEQGKELFTFggrgkDDGQFNLPNGLFID-DDGRLYVTD 259

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

376-535

6.12e-04

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 43.43 E-value: 6.12e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  376 IAIDYDpleGYVYWTDDEVRAIRRAYLDGSGAQTL-----VNTEINDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGT-- 448
Cdd:cd14956     65 LAVDKD---GWLYVADYWGDRIQVFTLTGELQTIGgssgsGPGQFNAPRGVAVD-ADGNLYVADFGNQRIQKFDPDGSfl 140

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  449 ----SRKILVSEdLDEPRAIVLHPVmGLMYWTDwGENPKIECANLDGQERHIL--VNTSLGW---PNGLALDlQEGKLYW 519
Cdd:cd14956    141 rqwgGTGIEPGS-FNYPRGVAVDPD-GTLYVAD-TYNDRIQVFDNDGAFLRKWggRGTGPGQfnyPYGIAID-PDGNVFV 216

                          170
                   ....*....|....*.
gi 1387253649  520 GDAKTDKIEVIDVDGT 535
Cdd:cd14956    217 ADFGNNRIQKFTADGT 232

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

970-1009

6.15e-04

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 38.74 E-value: 6.15e-04

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1387253649   970 ILPLHGLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQ 1009
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDwGLDVIEVANLDGTN 42

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

380-571

6.97e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 43.34 E-value: 6.97e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  380 YDPlEGYVYWTDDEVRAIRRAYLDGSGAQTLVNTEiNDPDGIAVD-----WVARN---LYWTDTGTDRIEVtrlngtsrk 451
Cdd:COG3386     15 WDP-DGRLYWVDIPGGRIHRYDPDGGAVEVFAEPS-GRPNGLAFDpdgrlLVADHgrgLVRFDPADGEVTV--------- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  452 ilVSEDLDEPRA----IVLHPvMGLMYWTD---WGENPKIECANLDGQERHILvnTSLGWPNGLALDLQEGKLYWGDAKT 524
Cdd:COG3386     84 --LADEYGKPLNrpndGVVDP-DGRLYFTDmgeYLPTGALYRVDPDGSLRVLA--DGLTFPNGIAFSPDGRTLYVADTGA 158

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1387253649  525 DKIEVIDVDGT----KRRTLLEDKLPHIF--GFTLLGD-FIYWTDWQRRSIERV 571
Cdd:COG3386    159 GRIYRFDLDADgtlgNRRVFADLPDGPGGpdGLAVDADgNLWVALWGGGGVVRF 212

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

712-824

8.48e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 42.96 E-value: 8.48e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  712 VIEFGLDYPEGMAVDWMGkNLYWADTGTNRIevARLDGQFRQVLVWRDLDN-PRSLALDPtKGYIYWTEwgGKPRIVRAF 790
Cdd:COG3386      2 LADAGFRLGEGPVWDPDG-RLYWVDIPGGRI--HRYDPDGGAVEVFAEPSGrPNGLAFDP-DGRLLVAD--HGRGLVRFD 75

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1387253649  791 MDGTNCMTLVDKVG----RANDLTIDyADQRLYWTDLD 824
Cdd:COG3386     76 PADGEVTVLADEYGkplnRPNDGVVD-PDGRLYFTDMG 112

NHL

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...

67-260

9.32e-04

Pssm-ID: 271320 [Multi-domain] Cd Length: 269 Bit Score: 43.08 E-value: 9.32e-04

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649   67 AVDfqfSKGAVYWTDVSEEAIKQtyLNQTGAAVQNVVISG-----LVSPDGLACDwVGKKLYWTDSETNRIEVANLNGTS 141
Cdd:cd05819     14 AVD---SSGNIYVADTGNNRIQV--FDPDGNFITSFGSFGsgdgqFNEPAGVAVD-SDGNLYVADTGNHRIQKFDPDGNF 87

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  142 RKV-----LFWQDLDQPRAIALDPAhGYMYWTDWGETpRIERAGMDGSTRKII-----VDSDIYWPNGLTIDlEEQKLYW 211
Cdd:cd05819     88 LASfggsgDGDGEFNGPRGIAVDSS-GNIYVADTGNH-RIQKFDPDGEFLTTFgsggsGPGQFNGPTGVAVD-SDGNIYV 164

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1387253649  212 ADAKLSFIHRANLDGSF-----RQKVVEGSLTHPFALTLSGD-TLYWTDWQTRSI 260
Cdd:cd05819    165 ADTGNHRIQVFDPDGNFlttfgSTGTGPGQFNYPTGIAVDSDgNIYVADSGNNRV 219

NHL_like_4

cd14955

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...

718-776

1.01e-03

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 42.95 E-value: 1.01e-03

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387253649  718 DYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQFrqVLVW-------RDLDNPRSLALDPTkGYIY 776
Cdd:cd14955     16 NSPSGIAVDSAG-NVYVADTGNNRIQKFDSTGTF--LTKWgssgsgdGQFYSPTGIAVDSD-GNVY 77

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

661-742

1.24e-03

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 42.58 E-value: 1.24e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  661 DTNNNDV-----------AIPLTGVKEASALDFDVSNNhIYWTDVSLKTISRaFMNGSSVEHVIEF-GLDYPEGMAVDWM 728
Cdd:cd14952    153 DTGNNRVlklaagsttqtVLPFTGLNSPSGVAVDTAGN-VYVTDHGNNRVLK-LAAGSTTPTVLPFtGLNGPLGVAVDAA 230

                           90
                   ....*....|....
gi 1387253649  729 GkNLYWADTGTNRI 742
Cdd:cd14952    231 G-NVYVADRGNDRV 243

NHL_PKND_like

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...

374-440

1.91e-03

Pssm-ID: 271322 [Multi-domain] Cd Length: 247 Bit Score: 41.81 E-value: 1.91e-03

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1387253649  374 HAIAIDydpLEGYVYWTDDEVRAIRRayLD-GSGAQT-LVNTEINDPDGIAVDwVARNLYWTDTGTDRI 440
Cdd:cd14952    181 SGVAVD---TAGNVYVTDHGNNRVLK--LAaGSTTPTvLPFTGLNGPLGVAVD-AAGNVYVADRGNDRV 243

NHL_TRIM71_like

cd14954

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...

717-776

2.54e-03

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.

Pssm-ID: 271324 [Multi-domain] Cd Length: 285 Bit Score: 41.76 E-value: 2.54e-03

                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387253649  717 LDYPEGMAVDWMGkNLYWADTGTNRIEVARLDGQF-----RQVLVWRDLDNPRSLALDPTkGYIY 776
Cdd:cd14954    117 FNYPWGVAVDSEG-RIYVSDTRNHRVQVFDSDGQFirkfgFEGAGPGQLDSPRGVAVNPD-GNIV 179

NHL_like_3

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...

416-535

2.80e-03

Pssm-ID: 271326 [Multi-domain] Cd Length: 274 Bit Score: 41.50 E-value: 2.80e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  416 NDPDGIAVDwVARNLYWTDTGTDRIEVTRLNGTSRKILVS-----EDLDEPRAIVLHPvMGLMYWTDwGENPKIECANLD 490
Cdd:cd14956     13 KDPRGIAVD-ADDNVYVADARNGRIQVFDKDGTFLRRFGTtgdgpGQFGRPRGLAVDK-DGWLYVAD-YWGDRIQVFTLT 89

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1387253649  491 GQERHIL-----VNTSLGWPNGLALDLQeGKLYWGDAKTDKIEVIDVDGT 535
Cdd:cd14956     90 GELQTIGgssgsGPGQFNAPRGVAVDAD-GNLYVADFGNQRIQKFDPDGS 138

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

515-553

3.11e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 36.75 E-value: 3.11e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1387253649  515 GKLYWGDAKTD-KIEVIDVDGTKRRTLLEDKLPHIFGFTL 553
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAV 40

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

773-813

3.64e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 36.75 E-value: 3.64e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387253649  773 GYIYWTEWGGKPRIVRAFMDGTNCMTLV-DKVGRANDLTIDY 813
Cdd:pfam00058    1 GRLYWTDSSLRASISSADLNGSDRKTLFtDDLQHPNAIAVDP 42

YvrE

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...

646-788

3.69e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway

Pssm-ID: 442613 [Multi-domain] Cd Length: 266 Bit Score: 41.03 E-value: 3.69e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  646 FLVFTSRAAIHRISLDTNNNDVAIPLTGVKEASA--LDFDvSNNHIYWTDVSLKTISRA---FMNGSSVEHVIEfGLDYP 720
Cdd:COG3386     62 LLVADHGRGLVRFDPADGEVTVLADEYGKPLNRPndGVVD-PDGRLYFTDMGEYLPTGAlyrVDPDGSLRVLAD-GLTFP 139

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387253649  721 EGMAVDWMGKNLYWADTGTNRIEVARL--DGQFRQVLVWRDLD----NPRSLALDpTKGYIYWTEWGGKpRIVR 788
Cdd:COG3386    140 NGIAFSPDGRTLYVADTGAGRIYRFDLdaDGTLGNRRVFADLPdgpgGPDGLAVD-ADGNLWVALWGGG-GVVR 211

NHL_like_4

cd14955

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...

717-794

5.18e-03

Pssm-ID: 271325 [Multi-domain] Cd Length: 279 Bit Score: 40.64 E-value: 5.18e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  717 LDYPEGMAVDWMGkNLYWADTGTNRIE--------VARL------DGQFrqvlvwrdlDNPRSLALDPTkGYIYWTEWGG 782
Cdd:cd14955     62 FYSPTGIAVDSDG-NVYVADTGNHRIQkfdstgtfLTKWgssgsgDGQF---------NSPSGIAVDSA-GNVYVTDSGN 130

                           90
                   ....*....|..
gi 1387253649  783 kPRIVRAFMDGT 794
Cdd:cd14955    131 -NRIQKFDSSGT 141

Vgb

COG4257

Streptogramin lyase [Defense mechanisms];

108-268

6.81e-03

Streptogramin lyase [Defense mechanisms];

Pssm-ID: 443399 [Multi-domain] Cd Length: 270 Bit Score: 40.39 E-value: 6.81e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  108 VSPDGlacdwvgkKLYWTDSETNRIEVANLNGTSRKVLFWQDLDQPRAIALDPAhGYMYWTDWGETpRIERAGM-DGSTR 186
Cdd:COG4257     24 VDPDG--------AVWFTDQGGGRIGRLDPATGEFTEYPLGGGSGPHGIAVDPD-GNLWFTDNGNN-RIGRIDPkTGEIT 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  187 KIIVDSDIYWPNGLTIDlEEQKLYWADAKLSFIHRANLD-GSFRQKVVEGSLTHPFALTLSGD-TLYWTDWQTRSIHACN 264
Cdd:COG4257     94 TFALPGGGSNPHGIAFD-PDGNLWFTDQGGNRIGRLDPAtGEVTEFPLPTGGAGPYGIAVDPDgNLWVTDFGANAIGRID 172


                   ....
gi 1387253649  265 KRTG 268
Cdd:COG4257    173 PDTG 176

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

1060-1103

7.15e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 36.04 E-value: 7.15e-03

                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1387253649  1060 MVLRGDRDKPRAIVVNAERGYLYFTNMqdRAAKIERAALDGTER 1103
Cdd:smart00135    2 TLLSSGLGHPNGLAVDWIEGRLYWTDW--GLDVIEVANLDGTNR 43

Ldl_recept_b

Low-density lipoprotein receptor repeat class B; This domain is also known as the YWTD motif ...

856-896

7.48e-03

Pssm-ID: 459654 Cd Length: 42 Bit Score: 35.98 E-value: 7.48e-03

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1387253649  856 DYIYWTDWNLH-SIERADKTSGRNRTLIQGHLDFVMDILVFH 896
Cdd:pfam00058    1 GRLYWTDSSLRaSISSADLNGSDRKTLFTDDLQHPNAIAVDP 42

YncE

DNA-binding beta-propeller fold protein YncE [General function prediction only];

656-741

9.05e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];

Pssm-ID: 442618 [Multi-domain] Cd Length: 237 Bit Score: 39.68 E-value: 9.05e-03

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387253649  656 HRIS-LDTNNNDVAIPLTGVKEASALDFDVSNNHIYWTDVSLKTISR--AFMNGSS--VEHVIEFGlDYPEGMAVDWMGK 730
Cdd:COG3391    132 GRVSvIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNTVSVivSVIDTATgkVVATIPVG-GGPVGVAVSPDGR 210

                           90
                   ....*....|.
gi 1387253649  731 NLYWADTGTNR 741
Cdd:COG3391    211 RLYVANRGSNT 221

Low-density lipoprotein-receptor YWTD domain; Type "B" repeats in low-density lipoprotein (LDL) ...

230-264

9.90e-03

Pssm-ID: 214531 [Multi-domain] Cd Length: 43 Bit Score: 35.66 E-value: 9.90e-03

                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1387253649   230 QKVVEGSLTHP--FALTLSGDTLYWTDWQTRSIHACN 264
Cdd:smart00135    1 RTLLSSGLGHPngLAVDWIEGRLYWTDWGLDVIEVAN 37

Ldl_recept_b