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Conserved domains on  [gi|1387271989|ref|XP_024848846|]
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toll-like receptor 6 isoform X1 [Bos taurus]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-784 9.67e-38

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 137.45  E-value: 9.67e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  641 QFHAFISYSEHDsaWVKNELIPNLEK--EDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387271989  719 AHHNLFHEGSNNLILILLEPIPQnTIPDRYHKLRALMaQRTYLEWPKEKNKHglFWANIRAAFNIK 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-165 2.63e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  35 VVDMSKTSLIHVPKDLP--PKTKVLDLSQNNISELHlSDISFLSGLRVLRLSHNRIQGLDISIFKFNHdLEYLDLSHNQL 112
Cdd:COG4886   117 SLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQI 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1387271989 113 QKIScHPIT--TTLKHLDLSFNDFDALPicKEFGNLTQLNFLGLSATKLQQLDLL 165
Cdd:COG4886   195 TDLP-EPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
237-531 7.38e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 7.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 237 VLLKFLSGLTGGPTLLNFTLNHMETTWKCLVKVFQFLWPKPIEYLNIYNLTIVESIDEEVFTYYKTTLKALKIEHITNKV 316
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 317 FIFSQTALYTVFSEMNILMLTISDTRFIHMLcpqepSTFKFLNFTQNSFTDsVFQNCDTLARLETLILQKNELKDLfKTS 396
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL-PEP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 397 LmtKDMLSLETLDVSWNSLEY-DRSNGNCSwvgSIVVLNLSSNALTD--SVFRCLPpRIKVLDLHNNRIRSIPKDVTGLE 473
Cdd:COG4886   155 L--GNLTNLKSLDLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLT 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1387271989 474 TLQELNLASNSLAHLPGCGIFSSLSILIIDYNSISNPSadFFQSCQKIRSLKVGNNPF 531
Cdd:COG4886   229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 3.68e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 3.68e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1387271989  529 NPFQCSCELRDFIQSVGQvssDVVEGWPESYKCDYPESYKGtPLKDFQVSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-784 9.67e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 137.45  E-value: 9.67e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  641 QFHAFISYSEHDsaWVKNELIPNLEK--EDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387271989  719 AHHNLFHEGSNNLILILLEPIPQnTIPDRYHKLRALMaQRTYLEWPKEKNKHglFWANIRAAFNIK 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-774 1.82e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 88.96  E-value: 1.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 642 FHAFISYSEHDS-AWVKNELIPNLEKEDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 721 HNLFhEGSNNLILILLEPIPQ------NTIPDRYHKLRALMAQRTYLEWPKEKNKHGLFW 774
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSdvrkqtGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIW 139
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-165 2.63e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  35 VVDMSKTSLIHVPKDLP--PKTKVLDLSQNNISELHlSDISFLSGLRVLRLSHNRIQGLDISIFKFNHdLEYLDLSHNQL 112
Cdd:COG4886   117 SLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQI 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1387271989 113 QKIScHPIT--TTLKHLDLSFNDFDALPicKEFGNLTQLNFLGLSATKLQQLDLL 165
Cdd:COG4886   195 TDLP-EPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
237-531 7.38e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 7.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 237 VLLKFLSGLTGGPTLLNFTLNHMETTWKCLVKVFQFLWPKPIEYLNIYNLTIVESIDEEVFTYYKTTLKALKIEHITNKV 316
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 317 FIFSQTALYTVFSEMNILMLTISDTRFIHMLcpqepSTFKFLNFTQNSFTDsVFQNCDTLARLETLILQKNELKDLfKTS 396
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL-PEP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 397 LmtKDMLSLETLDVSWNSLEY-DRSNGNCSwvgSIVVLNLSSNALTD--SVFRCLPpRIKVLDLHNNRIRSIPKDVTGLE 473
Cdd:COG4886   155 L--GNLTNLKSLDLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLT 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1387271989 474 TLQELNLASNSLAHLPGCGIFSSLSILIIDYNSISNPSadFFQSCQKIRSLKVGNNPF 531
Cdd:COG4886   229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR_8 pfam13855
Leucine rich repeat;
76-134 1.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387271989  76 SGLRVLRLSHNRIQGLDISIFKFNHDLEYLDLSHNQLQKISCHPIT--TTLKHLDLSFNDF 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSglPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 3.68e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 3.68e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1387271989  529 NPFQCSCELRDFIQSVGQvssDVVEGWPESYKCDYPESYKGtPLKDFQVSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-141 9.88e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 9.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  55 KVLDLSQNNIS------------ELHLSD---------------ISFLSG-LRVLRLSHNRIQglDISIFKFNHDLEYLD 106
Cdd:cd21340    71 KKLYLGGNRISvveglenltnleELHIENqrlppgekltfdprsLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLD 148

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1387271989 107 LSHNQLQKIS--CHPITT--TLKHLDLSFNdfdalPICK 141
Cdd:cd21340   149 ASNNQISDLEelLDLLSSwpSLRELDLTGN-----PVCK 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-494 1.57e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  46 VPKDLPPKTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRIQG-LDISIFKFNhDLEYLDLSHNQL---------QKI 115
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLT-SLEFLTLASNQLvgqiprelgQMK 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 116 SCHPI-----------------TTTLKHLDLSFNDFDAlPICKEFGNLTQLNFLGLSATKLQqlDLLPIAHLHLS-CILL 177
Cdd:PLN00113  213 SLKWIylgynnlsgeipyeiggLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQkLISL 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 178 DLEDYMKENKKESL--QILNTKKLHLvFHPNsfFSVQVDISANSLGCLQLTNIKLNDYNCQVLLKFlsGLTGGPTLLNFT 255
Cdd:PLN00113  290 DLSDNSLSGEIPELviQLQNLEILHL-FSNN--FTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNL--GKHNNLTVLDLS 364

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 256 LNHmettwkclvkvfqfLWPKPIEYL----NIYNLTIVE-SIDEEVFTYYkTTLKALKIEHITNKVFifsQTALYTVFSE 330
Cdd:PLN00113  365 TNN--------------LTGEIPEGLcssgNLFKLILFSnSLEGEIPKSL-GACRSLRRVRLQDNSF---SGELPSEFTK 426

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 331 MNIL-MLTISDTRFIHMLCPQ--EPSTFKFLNFTQNSFTDSVFQNCDTlARLETLILQKNELKDLFKTSLMTkdMLSLET 407
Cdd:PLN00113  427 LPLVyFLDISNNNLQGRINSRkwDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGS--LSELMQ 503

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 408 LDVSWNSL--EYDRSNGNCSwvgSIVVLNLSSNALTDSVFRCLP--PRIKVLDLHNNRIR-SIPKDVTGLETLQELNLAS 482
Cdd:PLN00113  504 LKLSENKLsgEIPDELSSCK---KLVSLDLSHNQLSGQIPASFSemPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISH 580

                         490
                  ....*....|...
gi 1387271989 483 NSL-AHLPGCGIF 494
Cdd:PLN00113  581 NHLhGSLPSTGAF 593
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-138 2.00e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  42 SLIHVPKDLPPKTKVLDLSQNNISEL--HLSdisflSGLRVLRLSHNRIQGLDISIfkfNHDLEYLDLSHNQLQKISCHp 119
Cdd:PRK15370  231 QLTSIPATLPDTIQEMELSINRITELpeRLP-----SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAH- 301

                          90
                  ....*....|....*....
gi 1387271989 120 ITTTLKHLDLSFNDFDALP 138
Cdd:PRK15370  302 LPSGITHLNVQSNSLTALP 320
LRR_8 pfam13855
Leucine rich repeat;
450-507 1.56e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387271989 450 PRIKVLDLHNNRIRSIPKDV-TGLETLQELNLASNSLAHLPGCGIF--SSLSILIIDYNSI 507
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSglPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 363-498 5.47e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 5.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 363 NSFTDS---VFQNCDTLARLETLILQKNELKDL---FKTSLMTKDMLSLETLDVSWNSLEYDRSN---GNCSWVGSIVVL 433
Cdd:cd00116    91 NALGPDgcgVLESLLRSSSLQELKLNNNGLGDRglrLLAKGLKDLPPALEKLVLGRNRLEGASCEalaKALRANRDLKEL 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1387271989 434 NLSSNALTDSVFRCLPP------RIKVLDLHNNRIRS--------IPKDvtgLETLQELNLASNSLAHLPGCGIFSSLS 498
Cdd:cd00116   171 NLANNGIGDAGIRALAEglkancNLEVLDLNNNGLTDegasalaeTLAS---LKSLEVLNLGDNNLTDAGAAALASALL 246
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
641-784 9.67e-38

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 137.45  E-value: 9.67e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  641 QFHAFISYSEHDsaWVKNELIPNLEK--EDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYF 718
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1387271989  719 AHHNLFHEGSNNLILILLEPIPQnTIPDRYHKLRALMaQRTYLEWPKEKNKHglFWANIRAAFNIK 784
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPS-DVRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 642-774 1.82e-20

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 88.96  E-value: 1.82e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 642 FHAFISYSEHDS-AWVKNELIPNLEKEDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 720
Cdd:pfam01582   1 YDVFLSFRGSDTrEWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 721 HNLFhEGSNNLILILLEPIPQ------NTIPDRYHKLRALMAQRTYLEWPKEKNKHGLFW 774
Cdd:pfam01582  81 ECAL-DLGQKVIPIFYEVDPSdvrkqtGSFGKAFKKHKKVLTEEKVLKWRGALNEVANIW 139
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 645-738 2.70e-17

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 78.51  E-value: 2.70e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 645 FISYSEHDSAWVKnELIPNLEKEDIRICLHERNFVAGKSIVENIINCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 724
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 1387271989 725 HEGSNNLILILLEP 738
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-165 2.63e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 2.63e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  35 VVDMSKTSLIHVPKDLP--PKTKVLDLSQNNISELHlSDISFLSGLRVLRLSHNRIQGLDISIFKFNHdLEYLDLSHNQL 112
Cdd:COG4886   117 SLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTN-LKELDLSNNQI 194

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1387271989 113 QKIScHPIT--TTLKHLDLSFNDFDALPicKEFGNLTQLNFLGLSATKLQQLDLL 165
Cdd:COG4886   195 TDLP-EPLGnlTNLEELDLSGNQLTDLP--EPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
237-531 7.38e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 71.12  E-value: 7.38e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 237 VLLKFLSGLTGGPTLLNFTLNHMETTWKCLVKVFQFLWPKPIEYLNIYNLTIVESIDEEVFTYYKTTLKALKIEHITNKV 316
Cdd:COG4886     2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 317 FIFSQTALYTVFSEMNILMLTISDTRFIHMLcpqepSTFKFLNFTQNSFTDsVFQNCDTLARLETLILQKNELKDLfKTS 396
Cdd:COG4886    82 LSLLLLGLTDLGDLTNLTELDLSGNEELSNL-----TNLESLDLSGNQLTD-LPEELANLTNLKELDLSNNQLTDL-PEP 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 397 LmtKDMLSLETLDVSWNSLEY-DRSNGNCSwvgSIVVLNLSSNALTD--SVFRCLPpRIKVLDLHNNRIRSIPKDVTGLE 473
Cdd:COG4886   155 L--GNLTNLKSLDLSNNQLTDlPEELGNLT---NLKELDLSNNQITDlpEPLGNLT-NLEELDLSGNQLTDLPEPLANLT 228

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1387271989 474 TLQELNLASNSLAHLPGCGIFSSLSILIIDYNSISNPSadFFQSCQKIRSLKVGNNPF 531
Cdd:COG4886   229 NLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
356-546 1.70e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 63.80  E-value: 1.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 356 KFLNFTQNSFTD--SVFQNcdtLARLETLILQKNELKDLfKTSLmtKDMLSLETLDVSWNSLEY-DRSNGNCSwvgSIVV 432
Cdd:COG4886   139 KELDLSNNQLTDlpEPLGN---LTNLKSLDLSNNQLTDL-PEEL--GNLTNLKELDLSNNQITDlPEPLGNLT---NLEE 209

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 433 LNLSSNALTD---SVFRClpPRIKVLDLHNNRIRSIPkDVTGLETLQELNLASNSLAHLPGCGIFSSLSILIIDYNSISN 509
Cdd:COG4886   210 LDLSGNQLTDlpePLANL--TNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTD 286

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1387271989 510 PSADFFQSCQKIRSLKVGNNPFQCSCELRDFIQSVGQ 546
Cdd:COG4886   287 LKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTL 323
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
55-238 1.14e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  55 KVLDLSQNNISELHLSdISFLSGLRVLRLSHNRIQglDISIFKFNHDLEYLDLSHNQLQKISCHPITTTLKHLDLSFNDF 134
Cdd:COG4886   208 EELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLT--DLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQL 284

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 135 DALpickEFGNLTQLNFLGLSATKLQQLDLLPIAHLHLSCILLDLEDYMKENKKESLQILNTKKLHLVFHPNSFFSVQVD 214
Cdd:COG4886   285 TDL----KLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLS 360

                         170       180
                  ....*....|....*....|....
gi 1387271989 215 ISANSLGCLQLTNIKLNDYNCQVL 238
Cdd:COG4886   361 LLLTLLLTLGLLGLLEATLLTLAL 384
LRR_8 pfam13855
Leucine rich repeat;
76-134 1.83e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.37  E-value: 1.83e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387271989  76 SGLRVLRLSHNRIQGLDISIFKFNHDLEYLDLSHNQLQKISCHPIT--TTLKHLDLSFNDF 134
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSglPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
52-112 3.16e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 3.16e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387271989  52 PKTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRIQGLDISIFKFNHDLEYLDLSHNQL 112
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
529-582 3.68e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 3.68e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1387271989  529 NPFQCSCELRDFIQSVGQvssDVVEGWPESYKCDYPESYKGtPLKDFQVSELSC 582
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-163 7.18e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 7.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  39 SKTSLIHVPKDLPPKTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRiqgldiSIFKFNhDLEYLDLSHNQLQKIsch 118
Cdd:COG4886    59 DLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLT-NLESLDLSGNQLTDL--- 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1387271989 119 PIT----TTLKHLDLSFNDFDALPicKEFGNLTQLNFLGLSATKLQQLD 163
Cdd:COG4886   129 PEElanlTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLTDLP 175
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-141 9.88e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 50.55  E-value: 9.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  55 KVLDLSQNNIS------------ELHLSD---------------ISFLSG-LRVLRLSHNRIQglDISIFKFNHDLEYLD 106
Cdd:cd21340    71 KKLYLGGNRISvveglenltnleELHIENqrlppgekltfdprsLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLD 148

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1387271989 107 LSHNQLQKIS--CHPITT--TLKHLDLSFNdfdalPICK 141
Cdd:cd21340   149 ASNNQISDLEelLDLLSSwpSLRELDLTGN-----PVCK 182
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 46-494 1.57e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.77  E-value: 1.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  46 VPKDLPPKTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRIQG-LDISIFKFNhDLEYLDLSHNQL---------QKI 115
Cdd:PLN00113  134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGkIPNSLTNLT-SLEFLTLASNQLvgqiprelgQMK 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 116 SCHPI-----------------TTTLKHLDLSFNDFDAlPICKEFGNLTQLNFLGLSATKLQqlDLLPIAHLHLS-CILL 177
Cdd:PLN00113  213 SLKWIylgynnlsgeipyeiggLTSLNHLDLVYNNLTG-PIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQkLISL 289

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 178 DLEDYMKENKKESL--QILNTKKLHLvFHPNsfFSVQVDISANSLGCLQLTNIKLNDYNCQVLLKFlsGLTGGPTLLNFT 255
Cdd:PLN00113  290 DLSDNSLSGEIPELviQLQNLEILHL-FSNN--FTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNL--GKHNNLTVLDLS 364

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 256 LNHmettwkclvkvfqfLWPKPIEYL----NIYNLTIVE-SIDEEVFTYYkTTLKALKIEHITNKVFifsQTALYTVFSE 330
Cdd:PLN00113  365 TNN--------------LTGEIPEGLcssgNLFKLILFSnSLEGEIPKSL-GACRSLRRVRLQDNSF---SGELPSEFTK 426

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 331 MNIL-MLTISDTRFIHMLCPQ--EPSTFKFLNFTQNSFTDSVFQNCDTlARLETLILQKNELKDLFKTSLMTkdMLSLET 407
Cdd:PLN00113  427 LPLVyFLDISNNNLQGRINSRkwDMPSLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGS--LSELMQ 503

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 408 LDVSWNSL--EYDRSNGNCSwvgSIVVLNLSSNALTDSVFRCLP--PRIKVLDLHNNRIR-SIPKDVTGLETLQELNLAS 482
Cdd:PLN00113  504 LKLSENKLsgEIPDELSSCK---KLVSLDLSHNQLSGQIPASFSemPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISH 580

                         490
                  ....*....|...
gi 1387271989 483 NSL-AHLPGCGIF 494
Cdd:PLN00113  581 NHLhGSLPSTGAF 593
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
42-138 2.00e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 51.62  E-value: 2.00e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  42 SLIHVPKDLPPKTKVLDLSQNNISEL--HLSdisflSGLRVLRLSHNRIQGLDISIfkfNHDLEYLDLSHNQLQKISCHp 119
Cdd:PRK15370  231 QLTSIPATLPDTIQEMELSINRITELpeRLP-----SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAH- 301

                          90
                  ....*....|....*....
gi 1387271989 120 ITTTLKHLDLSFNDFDALP 138
Cdd:PRK15370  302 LPSGITHLNVQSNSLTALP 320
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
379-507 2.99e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 2.99e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 379 LETLILQKNELKDLfktslmtKDML--SLETLDVSWNSLEYDRSNgncsWVGSIVVLNLSSNALT--------------- 441
Cdd:PRK15370  264 LQSLDLFHNKISCL-------PENLpeELRYLSVYDNSIRTLPAH----LPSGITHLNVQSNSLTalpetlppglktlea 332

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387271989 442 -DSVFRCLP----PRIKVLDLHNNRIRSIPKDVTglETLQELNLASNSLAHLPGcGIFSSLSILIIDYNSI 507
Cdd:PRK15370  333 gENALTSLPaslpPELQVLDVSKNQITVLPETLP--PTITTLDVSRNALTNLPE-NLPAALQIMQASRNNL 400
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 353-565 1.96e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.31  E-value: 1.96e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 353 STFKFLNFTQNSFTDSVFQNCDTLARLETLILQKNELKDLFKTSLMtkDMLSLETLDVSWNSLEYDRSNgNCSWVGSIVV 432
Cdd:PLN00113  236 TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIF--SLQKLISLDLSDNSLSGEIPE-LVIQLQNLEI 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 433 LNLSSNALTDSVFRCLP--PRIKVLDLHNNRIR-SIPKDVTGLETLQELNLASNSLAHLPGCGIFSS--LSILIIDYNSI 507
Cdd:PLN00113  313 LHLFSNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSgnLFKLILFSNSL 392

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1387271989 508 SNPSADFFQSCQKIRSLKVGNNPFqcSCEL-RDF--IQSVG--QVSSDVVEGWPESYKCDYPE 565
Cdd:PLN00113  393 EGEIPKSLGACRSLRRVRLQDNSF--SGELpSEFtkLPLVYflDISNNNLQGRINSRKWDMPS 453
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
378-529 3.11e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 3.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 378 RLETLILQKNELKDL-------FKT-SLMTKDMLSL-ETLDVSWNSLEYDRSNGNC---SWVGSIVVLNLSSNALTdSVF 445
Cdd:PRK15370  200 QITTLILDNNELKSLpenlqgnIKTlYANSNQLTSIpATLPDTIQEMELSINRITElpeRLPSALQSLDLFHNKIS-CLP 278

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 446 RCLPPRIKVLDLHNNRIRSIPKDVTglETLQELNLASNSLAHLPGCgIFSSLSILIIDYNSISNPSADFfqsCQKIRSLK 525
Cdd:PRK15370  279 ENLPEELRYLSVYDNSIRTLPAHLP--SGITHLNVQSNSLTALPET-LPPGLKTLEAGENALTSLPASL---PPELQVLD 352


                  ....
gi 1387271989 526 VGNN 529
Cdd:PRK15370  353 VSKN 356
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 53-531 1.30e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  53 KTKVLDLSQNNISELHLSDISFLSGLRVLRLSHNRIQG-LDISIFKFNHDLEYLDLSHNQLQKISCHPITTTLKHLDLSF 131
Cdd:PLN00113   70 RVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSGpIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIPNLETLDLSN 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 132 NDFDAlPICKEFGNLTQLNFLGLSATKLqqLDLLPIAHLHLScilldledymkenkkeSLQILNTKKLHLVFhpnsffsv 211
Cdd:PLN00113  150 NMLSG-EIPNDIGSFSSLKVLDLGGNVL--VGKIPNSLTNLT----------------SLEFLTLASNQLVG-------- 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 212 QVDISANSLGCLQLTNIKLNDYNCQVLLKfLSGLTggptllnfTLNHMETTWKCLVKvfqflwPKPIEYLNIYNLtives 291
Cdd:PLN00113  203 QIPRELGQMKSLKWIYLGYNNLSGEIPYE-IGGLT--------SLNHLDLVYNNLTG------PIPSSLGNLKNL----- 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 292 idEEVFTYykttlkalkiehiTNKvfiFSQTALYTVFSEMNILMLTISDTrFIHMLCPQ---EPSTFKFLNFTQNSFTDS 368
Cdd:PLN00113  263 --QYLFLY-------------QNK---LSGPIPPSIFSLQKLISLDLSDN-SLSGEIPElviQLQNLEILHLFSNNFTGK 323

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 369 VFQNCDTLARLETLILQKNEL-----KDLFKTSlmtkdmlSLETLDVSWNSLEYDRSNGNCSwVGSIVVLNLSSNALTDS 443
Cdd:PLN00113  324 IPVALTSLPRLQVLQLWSNKFsgeipKNLGKHN-------NLTVLDLSTNNLTGEIPEGLCS-SGNLFKLILFSNSLEGE 395

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 444 VFRCLPP--RIKVLDLHNNRIR-SIPKDVTGLETLQELNLASNSLA--------HLPgcgifsSLSILIIDYNSISNPSA 512
Cdd:PLN00113  396 IPKSLGAcrSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwDMP------SLQMLSLARNKFFGGLP 469

                         490
                  ....*....|....*....
gi 1387271989 513 DFFQScQKIRSLKVGNNPF 531
Cdd:PLN00113  470 DSFGS-KRLENLDLSRNQF 487
LRR_8 pfam13855
Leucine rich repeat;
450-507 1.56e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.56e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387271989 450 PRIKVLDLHNNRIRSIPKDV-TGLETLQELNLASNSLAHLPGCGIF--SSLSILIIDYNSI 507
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSglPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 55-125 1.82e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 43.62  E-value: 1.82e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1387271989  55 KVLDLSQNNISELhlSDISFLSGLRVLRLSHNRIQGLD---ISIFKFNHdLEYLDLSHNqlqkischPITTTLK 125
Cdd:cd21340   123 RVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEellDLLSSWPS-LRELDLTGN--------PVCKKPK 185
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 43-164 7.66e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.34  E-value: 7.66e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  43 LIHVPKDLPPKTKVLDLSQNNI----SELHLSDISFLSGLRVLRLSHNRIQGLDIS----IFKFNHDLEYLDLSHNQLQK 114
Cdd:cd00116   128 LAKGLKDLPPALEKLVLGRNRLegasCEALAKALRANRDLKELNLANNGIGDAGIRalaeGLKANCNLEVLDLNNNGLTD 207

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387271989 115 ISCHPITTTLKH------LDLSFNDFDALPICkefgnlTQLNFLGLSATKLQQLDL 164
Cdd:cd00116   208 EGASALAETLASlkslevLNLGDNNLTDAGAA------ALASALLSPNISLLTLSL 257
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 57-159 2.12e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 41.31  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989  57 LDLSQNNISELHLSDIS-FLSG---LRVLRLSHNRI---------QGLdisifKFNHDLEYLDLSHNQLQKISCHPIT-- 121
Cdd:COG5238   269 LYLSGNQIGAEGAIALAkALQGnttLTSLDLSVNRIgdegaialaEGL-----QGNKTLHTLNLAYNGIGAQGAIALAka 343

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1387271989 122 ----TTLKHLDLSFN---DFDALPICKEFGNLTQLNFLGLSATKL 159
Cdd:COG5238   344 lqenTTLHSLDLSDNqigDEGAIALAKYLEGNTTLRELNLGKNNI 388
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 363-498 5.47e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 5.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387271989 363 NSFTDS---VFQNCDTLARLETLILQKNELKDL---FKTSLMTKDMLSLETLDVSWNSLEYDRSN---GNCSWVGSIVVL 433
Cdd:cd00116    91 NALGPDgcgVLESLLRSSSLQELKLNNNGLGDRglrLLAKGLKDLPPALEKLVLGRNRLEGASCEalaKALRANRDLKEL 170

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1387271989 434 NLSSNALTDSVFRCLPP------RIKVLDLHNNRIRS--------IPKDvtgLETLQELNLASNSLAHLPGCGIFSSLS 498
Cdd:cd00116   171 NLANNGIGDAGIRALAEglkancNLEVLDLNNNGLTDegasalaeTLAS---LKSLEVLNLGDNNLTDAGAAALASALL 246
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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