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Conserved domains on  [gi|1387206846|ref|XP_024857234|]
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protein phosphatase 1 regulatory subunit 16A isoform X1 [Bos taurus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat domain-containing protein; ANK proteins mediate specific protein-protein interactions without necessarily recognizing specific primary sequences which allows for one ankyrin repeat domain to recognize and bind to a variety of intracellular substrates and may be involved in a wide array of functions

Gene Ontology:  GO:0005515
PubMed:  17176038
SCOP:  4000366

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-317 3.66e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 3.66e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVE 144
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 145 LLIARGADLLAVNTDGNMPydlcedeqtldcLETAmasrgITQDSIEQARAlpelhmledirnLLQAGANLDAPRDHGAT 224
Cdd:COG0666   138 LLLEAGADVNAQDNDGNTP------------LHLA-----AANGNLEIVKL------------LLEAGADVNARDNDGET 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 225 LLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPLD---VCGDEEVR 301
Cdd:COG0666   189 PLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLlaaAAGAALIV 268

                         250
                  ....*....|....*.
gi 1387206846 302 AKLLELKHKHDALLRA 317
Cdd:COG0666   269 KLLLLALLLLAAALLD 284
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-317 3.66e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 3.66e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVE 144
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 145 LLIARGADLLAVNTDGNMPydlcedeqtldcLETAmasrgITQDSIEQARAlpelhmledirnLLQAGANLDAPRDHGAT 224
Cdd:COG0666   138 LLLEAGADVNAQDNDGNTP------------LHLA-----AANGNLEIVKL------------LLEAGADVNARDNDGET 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 225 LLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPLD---VCGDEEVR 301
Cdd:COG0666   189 PLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLlaaAAGAALIV 268

                         250
                  ....*....|....*.
gi 1387206846 302 AKLLELKHKHDALLRA 317
Cdd:COG0666   269 KLLLLALLLLAAALLD 284
PHA03095 PHA03095
ankyrin-like protein; Provisional
 64-317 1.52e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 88.16  E-value: 1.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  64 TLLEAAARNDLEEVRQFLESGVSPDLANEDGLTALH-QSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAAT--CGHL 140
Cdd:PHA03095   53 LYLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINP 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 141 RLVELLIARGADLLAVNTDGNMPydlcedeqtLDCLetaMASRGITqdsIEQARALPE---------------LHMLED- 204
Cdd:PHA03095  133 KVIRLLLRKGADVNALDLYGMTP---------LAVL---LKSRNAN---VELLRLLIDagadvyavddrfrslLHHHLQs 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 205 -------IRNLLQAGANLDAPRDHGATLLHIAAANGFSEAAAL--LLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLV 275
Cdd:PHA03095  198 fkprariVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLI 277

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1387206846 276 AHGADLNGKSLMDETPLdvcgdeevrakLLELKHKHDALLRA 317
Cdd:PHA03095  278 ALGADINAVSSDGNTPL-----------SLMVRNNNGRAVRA 308
Ank_2 pfam12796
Ankyrin repeats (3 copies);
65-157 2.10e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.16  E-value: 2.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEaGARVNARDSEcWTPLHAAATCGHLRLVE 144
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNG-RTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1387206846 145 LLIARGADLLAVN 157
Cdd:pfam12796  79 LLLEKGADINVKD 91
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 54-275 2.00e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.48  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  54 QKRVLFPPsvtLLEAAARNDLEEVRQFLESGvSPDLANEDGL--TALHQSCIDDFREMVQQLLEAGAR-VN-ARDSECW- 128
Cdd:cd22192    13 QKRISESP---LLLAAKENDVQAIKKLLKCP-SCDLFQRGALgeTALHVAALYDNLEAAVVLMEAAPElVNePMTSDLYq 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 129 --TPLHAAATCGHLRLVELLIARGADLLAVNTDGNM----PYDLCE-DEQTLdcleTAMASRGitqdsieqaralpelhm 201
Cdd:cd22192    89 geTALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgPKNLIYyGEHPL----SFAACVG----------------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 202 LEDI-RNLLQAGANLDAPRDHGATLLHIAAANGFSEAAALLLEHQASLSAKDR----------DGWEPLHAAAYWGQVRL 270
Cdd:cd22192   148 NEEIvRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDKEDDlqpldlvpnnQGLTPFKLAAKEGNIVM 227


                  ....*
gi 1387206846 271 VELLV 275
Cdd:cd22192   228 FQHLV 232
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 65-308 1.55e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.77  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLES-GVSPDLanedGLTALHQSCIDDFR--EMVQQLLEAGAR-------VNARDSECW----TP 130
Cdd:TIGR00870  56 LFVAAIENENLELTELLLNlSCRGAV----GDTLLHAISLEYVDavEAILLHLLAAFRksgplelANDQYTSEFtpgiTA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 131 LHAAATCGHLRLVELLIARGADLlavntdgnmPYDLCEDEqtldCLETAMasrgitQDSIEqaralpelhmledirnllq 210
Cdd:TIGR00870 132 LHLAAHRQNYEIVKLLLERGASV---------PARACGDF----FVKSQG------VDSFY------------------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 211 aganldaprdHGATLLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAA----------------------YWGQV 268
Cdd:TIGR00870 174 ----------HGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLVmenefkaeyeelscqmynfalsLLDKL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1387206846 269 R-LVELLVAhgadLNGKslmDETPLDVCGDEEvRAKLLELK 308
Cdd:TIGR00870 244 RdSKELEVI----LNHQ---GLTPLKLAAKEG-RIVLFRLK 276
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 254-282 1.14e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.14e-04
                           10        20
                   ....*....|....*....|....*....
gi 1387206846  254 DGWEPLHAAAYWGQVRLVELLVAHGADLN 282
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-317 3.66e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.55  E-value: 3.66e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVE 144
Cdd:COG0666    58 LLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 145 LLIARGADLLAVNTDGNMPydlcedeqtldcLETAmasrgITQDSIEQARAlpelhmledirnLLQAGANLDAPRDHGAT 224
Cdd:COG0666   138 LLLEAGADVNAQDNDGNTP------------LHLA-----AANGNLEIVKL------------LLEAGADVNARDNDGET 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 225 LLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPLD---VCGDEEVR 301
Cdd:COG0666   189 PLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLlaaAAGAALIV 268

                         250
                  ....*....|....*.
gi 1387206846 302 AKLLELKHKHDALLRA 317
Cdd:COG0666   269 KLLLLALLLLAAALLD 284
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-292 3.75e-34

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 130.46  E-value: 3.75e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVE 144
Cdd:COG0666    91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVK 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 145 LLIARGADLLAVNTDGNMPYDLCedeqtldcletamasrgITQDSIEQARAlpelhmledirnLLQAGANLDAPRDHGAT 224
Cdd:COG0666   171 LLLEAGADVNARDNDGETPLHLA-----------------AENGHLEIVKL------------LLEAGADVNAKDNDGKT 221

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1387206846 225 LLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPL 292
Cdd:COG0666   222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
65-317 2.48e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 128.15  E-value: 2.48e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVE 144
Cdd:COG0666    25 LLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 145 LLIARGADLLAVNTDGNMPYDLCedeqtldcletamASRGItqdsieqaralpelhmLEDIRNLLQAGANLDAPRDHGAT 224
Cdd:COG0666   105 LLLEAGADVNARDKDGETPLHLA-------------AYNGN----------------LEIVKLLLEAGADVNAQDNDGNT 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 225 LLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPLDV---CGDEEVR 301
Cdd:COG0666   156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLaaeNGNLEIV 235

                         250
                  ....*....|....*.
gi 1387206846 302 AKLLELKHKHDALLRA 317
Cdd:COG0666   236 KLLLEAGADLNAKDKD 251
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
64-259 3.00e-26

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 108.50  E-value: 3.00e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  64 TLLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLV 143
Cdd:COG0666   123 PLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIV 202

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 144 ELLIARGADLLAVNTDGNMPYDLCEdeqtldcletamasrgitqdsieqaralpELHMLEDIRNLLQAGANLDAPRDHGA 223
Cdd:COG0666   203 KLLLEAGADVNAKDNDGKTALDLAA-----------------------------ENGNLEIVKLLLEAGADLNAKDKDGL 253

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1387206846 224 TLLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPL 259
Cdd:COG0666   254 TALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
140-306 7.86e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 86.93  E-value: 7.86e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 140 LRLVELLIARGADLLAVNTDGNMPYDLCEDEQTLDCLETAMASRGITQDSIEQARALPELHMLEDIRNLLQAGANLDAPR 219
Cdd:COG0666     5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 220 DHGATLLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPLDV---CG 296
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLaaaNG 164

                         170
                  ....*....|
gi 1387206846 297 DEEVRAKLLE 306
Cdd:COG0666   165 NLEIVKLLLE 174
PHA03095 PHA03095
ankyrin-like protein; Provisional
 64-317 1.52e-18

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 88.16  E-value: 1.52e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  64 TLLEAAARNDLEEVRQFLESGVSPDLANEDGLTALH-QSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAAT--CGHL 140
Cdd:PHA03095   53 LYLHYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIKAGADVNAKDKVGRTPLHVYLSgfNINP 132

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 141 RLVELLIARGADLLAVNTDGNMPydlcedeqtLDCLetaMASRGITqdsIEQARALPE---------------LHMLED- 204
Cdd:PHA03095  133 KVIRLLLRKGADVNALDLYGMTP---------LAVL---LKSRNAN---VELLRLLIDagadvyavddrfrslLHHHLQs 197

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 205 -------IRNLLQAGANLDAPRDHGATLLHIAAANGFSEAAAL--LLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLV 275
Cdd:PHA03095  198 fkprariVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLI 277

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1387206846 276 AHGADLNGKSLMDETPLdvcgdeevrakLLELKHKHDALLRA 317
Cdd:PHA03095  278 ALGADINAVSSDGNTPL-----------SLMVRNNNGRAVRA 308
Ank_2 pfam12796
Ankyrin repeats (3 copies);
65-157 2.10e-18

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 80.16  E-value: 2.10e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEaGARVNARDSEcWTPLHAAATCGHLRLVE 144
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNG-RTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 1387206846 145 LLIARGADLLAVN 157
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 104-292 3.28e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 78.57  E-value: 3.28e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 104 DDFReMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLIARGADLLAVNTDGNMPYDLCEDEQTLDCLETAMASR 183
Cdd:PHA02876  156 DELL-IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNR 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 184 GITQDSieqaralpELHMLEDIRN--------LLQAGANLDAPRDHGATLLHIAA-ANGFSEAAALLLEHQASLSAKDRD 254
Cdd:PHA02876  235 SNINKN--------DLSLLKAIRNedletsllLYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIK 306

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 1387206846 255 GWEPLHAAAYWG-QVRLVELLVAHGADLNGKSLMDETPL 292
Cdd:PHA02876  307 GETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPL 345
Ank_2 pfam12796
Ankyrin repeats (3 copies);
201-282 2.26e-14

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 68.60  E-value: 2.26e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 201 MLEDIRNLLQAGANLDAPRDHGATLLHIAAANGFSEAAALLLEHqASLSAKDrDGWEPLHAAAYWGQVRLVELLVAHGAD 280
Cdd:pfam12796   9 NLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAARSGHLEIVKLLLEKGAD 86


                  ..
gi 1387206846 281 LN 282
Cdd:pfam12796  87 IN 88
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 108-292 3.36e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 71.53  E-value: 3.36e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 108 EMVQQLLEA-GARVNARDSECWTPLHAAATCGHLRLVELLIARGADLLAVNTdgNMPYDLCE------------------ 168
Cdd:PHA02874   15 EAIEKIIKNkGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINT--KIPHPLLTaikigahdiikllidngv 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 169 DEQTLD--CLETAMASR----GITQDsIEQARALPELHM------LEDIRNLLQAGANLDAPRDHGATLLHIAAANGFSE 236
Cdd:PHA02874   93 DTSILPipCIEKDMIKTildcGIDVN-IKDAELKTFLHYaikkgdLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFD 171

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387206846 237 AAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPL 292
Cdd:PHA02874  172 IIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPL 227
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 81-292 7.16e-13

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 70.46  E-value: 7.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  81 LESGVSPDLANEDGLTALH-----QSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATC--GHLRLVELLIARGADL 153
Cdd:PHA03100   55 LDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANV 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 154 LAVNTDGNMPYdlcedeqtldcletAMASRGITQDsieqaralpelhmLEDIRNLLQAGANLDAprdhgatllhIAAANg 233
Cdd:PHA03100  135 NIKNSDGENLL--------------HLYLESNKID-------------LKILKLLIDKGVDINA----------KNRVN- 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1387206846 234 fseaaaLLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPL 292
Cdd:PHA03100  177 ------YLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPL 229
PHA03095 PHA03095
ankyrin-like protein; Provisional
 66-294 4.92e-12

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.13  E-value: 4.92e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  66 LEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQ---SCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGH-LR 141
Cdd:PHA03095   19 LLNASNVTVEEVRRLLAAGADVNFRGEYGKTPLHLylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHLYLYNATtLD 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 142 LVELLIARGADLLAVNTDGNMPydlcedeqtldcLETAMASRGITQDSIEQaralpelhmledirnLLQAGANLDAPRDH 221
Cdd:PHA03095   99 VIKLLIKAGADVNAKDKVGRTP------------LHVYLSGFNINPKVIRL---------------LLRKGADVNALDLY 151

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1387206846 222 GATLLHIaaangfseaaaLLLEHQASlsakdrdgweplhaaaywgqVRLVELLVAHGADLNGKSLMDETPLDV 294
Cdd:PHA03095  152 GMTPLAV-----------LLKSRNAN--------------------VELLRLLIDAGADVYAVDDRFRSLLHH 193
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 63-282 9.43e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 66.94  E-value: 9.43e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  63 VTLLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRL 142
Cdd:PHA02875    4 VALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 143 VELLIARGADLLAV-NTDGNMPYDLCEDEQTLDCLETamasrgitqdsieqaralpelhmledirnLLQAGANLDAPRDH 221
Cdd:PHA02875   84 VEELLDLGKFADDVfYKDGMTPLHLATILKKLDIMKL-----------------------------LIARGADPDIPNTD 134

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387206846 222 GATLLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLN 282
Cdd:PHA02875  135 KFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANID 195
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 107-294 3.91e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 64.98  E-value: 3.91e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 107 REMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLIARGADLLAVNTDGNMPYDLCEDEQTLDCLETAM---ASR 183
Cdd:PHA02874  104 KDMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLekgAYA 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 184 GITQDSIEQAralpeLHMLED------IRNLLQAGANLDAPRDHGATLLHIAAAngFSEAAALLLEHQASLSAKDRDGWE 257
Cdd:PHA02874  184 NVKDNNGESP-----LHNAAEygdyacIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGST 256

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 1387206846 258 PLH-AAAYWGQVRLVELLVAHGADLNGKSLMDETPLDV 294
Cdd:PHA02874  257 PLHhAINPPCDIDIIDILLYHKADISIKDNKGENPIDT 294
Ank_2 pfam12796
Ankyrin repeats (3 copies);
226-312 5.03e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.97  E-value: 5.03e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 226 LHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHgADLNGKSlMDETPLDVC---GDEEVrA 302
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKD-NGRTALHYAarsGHLEI-V 77

                          90
                  ....*....|
gi 1387206846 303 KLLeLKHKHD 312
Cdd:pfam12796  78 KLL-LEKGAD 86
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 63-292 8.76e-11

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 64.31  E-value: 8.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  63 VTLLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSC-IDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGH-L 140
Cdd:PHA02876  242 LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASqAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYdT 321

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 141 RLVELLIARGADLLAVNTDGNMPYdlcEDEQTLDCLE---TAMASRGITQDSIEQARALPeLHMLEdIRN-------LLQ 210
Cdd:PHA02876  322 ENIRTLIMLGADVNAADRLYITPL---HQASTLDRNKdivITLLELGANVNARDYCDKTP-IHYAA-VRNnvviintLLD 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 211 AGANLDAPRDHGATLLHIA--AANGFSeAAALLLEHQASLSAKDRDGWEPLHAAAYWG-QVRLVELLVAHGADLNGKSLM 287
Cdd:PHA02876  397 YGADIEALSQKIGTALHFAlcGTNPYM-SVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQ 475


                  ....*
gi 1387206846 288 DETPL 292
Cdd:PHA02876  476 NQYPL 480
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 108-294 1.95e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 62.98  E-value: 1.95e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 108 EMVQQLLEAGARVNARDSECW-TPLHAAATCGHLRLVELLIARGADLLAVNTDGNMPydlcedeqtldcLETAMASRGit 186
Cdd:PHA02878  148 EITKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDKTNNSP------------LHHAVKHYN-- 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 187 qdsieqaraLPELHMLedirnlLQAGANLDAPRDHGATLLHIAAANGFS-EAAALLLEHQASLSAKDR-DGWEPLHAAAY 264
Cdd:PHA02878  214 ---------KPIVHIL------LENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHGVDVNAKSYiLGLTALHSSIK 278

                         170       180       190
                  ....*....|....*....|....*....|
gi 1387206846 265 WGQVrlVELLVAHGADLNGKSLMDETPLDV 294
Cdd:PHA02878  279 SERK--LKLLLEYGADINSLNSYKLTPLSS 306
Ank_2 pfam12796
Ankyrin repeats (3 copies);
98-252 2.54e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 57.05  E-value: 2.54e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  98 LHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLIArgadllavNTDGNMpydlcedeqtldcle 177
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE--------HADVNL--------------- 57

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1387206846 178 tamasrgitqdsieqaralpelhmledirnllqaganldapRDHGATLLHIAAANGFSEAAALLLEHQASLSAKD 252
Cdd:pfam12796  58 -----------------------------------------KDNGRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 64-290 9.64e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 61.23  E-value: 9.64e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  64 TLLEAAARN--DLEEVRQFLESGVSPDLANEDGLTALHQ-SCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHL 140
Cdd:PHA02876  309 TPLYLMAKNgyDTENIRTLIMLGADVNAADRLYITPLHQaSTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNV 388

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 141 RLVELLIARGADLLAVNTDgnmpydlcedeqtldcLETAMASrgitqdsieqarALPELHMLEDIRNLLQAGANLDAPRD 220
Cdd:PHA02876  389 VIINTLLDYGADIEALSQK----------------IGTALHF------------ALCGTNPYMSVKTLIDRGANVNSKNK 440

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1387206846 221 HGATLLHIAAANGFS-EAAALLLEHQASLSAKD-RDGWEPLHAAAYWGqvrLVELLVAHGADLNGKSLMDET 290
Cdd:PHA02876  441 DLSTPLHYACKKNCKlDVIEMLLDNGADVNAINiQNQYPLLIALEYHG---IVNILLHYGAELRDSRVLHKS 509
PHA03095 PHA03095
ankyrin-like protein; Provisional
 202-307 1.76e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.04  E-value: 1.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 202 LEDIRNLLQAGANLDAPRDHGATLLHIAAANGFS---EAAALLLEHQASLSAKDRDGWEPLHAAAYWGQV-RLVELLVAH 277
Cdd:PHA03095   27 VEEVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVNAPERCGFTPLHLYLYNATTlDVIKLLIKA 106

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1387206846 278 GADLNGKSLMDETPLDVC-GDEEVRAKLLEL 307
Cdd:PHA03095  107 GADVNAKDKVGRTPLHVYlSGFNINPKVIRL 137
Ank_4 pfam13637
Ankyrin repeats (many copies);
224-275 6.28e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 51.89  E-value: 6.28e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1387206846 224 TLLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLV 275
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 110-198 6.95e-09

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.37  E-value: 6.95e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 110 VQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLIARGADLLAVNTDGNMPYDLCEDEQTLDCLEtaMASRGITQDS 189
Cdd:PTZ00322   98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQ--LLSRHSQCHF 175


                  ....*....
gi 1387206846 190 IEQARALPE 198
Cdd:PTZ00322  176 ELGANAKPD 184
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 186-277 1.35e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 57.60  E-value: 1.35e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 186 TQDSIEQARAlpelHMLE-------------DIRNLLQAGANLDAPRDHGATLLHIAAANGFSEAAALLLEHQASLSAKD 252
Cdd:PTZ00322   70 TEEVIDPVVA----HMLTvelcqlaasgdavGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLD 145

                          90       100
                  ....*....|....*....|....*
gi 1387206846 253 RDGWEPLHAAAYWGQVRLVELLVAH 277
Cdd:PTZ00322  146 KDGKTPLELAEENGFREVVQLLSRH 170
Ank_4 pfam13637
Ankyrin repeats (many copies);
94-147 1.92e-08

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 50.74  E-value: 1.92e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387206846  94 GLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLI 147
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 98-306 2.31e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 56.43  E-value: 2.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  98 LHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLIAR------GADLLAVNTDGN---------M 162
Cdd:PHA02878   41 LHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSinkcsvFYTLVAIKDAFNnrnveifkiI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 163 PYDLCEDEQTLDCLETAMASRgitQDSIEQaralpelhmlEDIRNLLQAGANLD-APRDHGATLLHIAAANGFSEAAALL 241
Cdd:PHA02878  121 LTNRYKNIQTIDLVYIDKKSK---DDIIEA----------EITKLLLSYGADINmKDRHKGNTALHYATENKDQRLTELL 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1387206846 242 LEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPLDV----CGDEEVRAKLLE 306
Cdd:PHA02878  188 LSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHIsvgyCKDYDILKLLLE 256
Ank_5 pfam13857
Ankyrin repeats (many copies);
113-167 2.50e-08

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.42  E-value: 2.50e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387206846 113 LLEAG-ARVNARDSECWTPLHAAATCGHLRLVELLIARGADLLAVNTDGNMPYDLC 167
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 68-262 3.00e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 56.13  E-value: 3.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  68 AAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLI 147
Cdd:PHA02874  131 AIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI 210

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 148 ARGADLLAVNTDGNMPydlcedeqtldcLETAMasrgitqdsIEQARALPelhmledirnLLQAGANLDAPRDHGATLLH 227
Cdd:PHA02874  211 DHGNHIMNKCKNGFTP------------LHNAI---------IHNRSAIE----------LLINNASINDQDIDGSTPLH 259

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1387206846 228 IAAANGFS-EAAALLLEHQASLSAKDRDGWEPLHAA 262
Cdd:PHA02874  260 HAINPPCDiDIIDILLYHKADISIKDNKGENPIDTA 295
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 65-254 3.08e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 56.41  E-value: 3.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVE 144
Cdd:PLN03192  529 LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFR 608

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 145 LL--IARGADllaVNTDGNMpydLCEdeqtldcletaMASRGitqdsieqaralpelhMLEDIRNLLQAGANLDAPRDHG 222
Cdd:PLN03192  609 ILyhFASISD---PHAAGDL---LCT-----------AAKRN----------------DLTAMKELLKQGLNVDSEDHQG 655

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1387206846 223 ATLLHIAAANGFSEAAALLLEHQASLSAKDRD 254
Cdd:PLN03192  656 ATALQVAMAEDHVDMVRLLIMNGADVDKANTD 687
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 109-354 6.69e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 55.26  E-value: 6.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 109 MVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLIARGADLLAVNTDGNmpydlcedeqtldcleTAMASrgitqd 188
Cdd:PLN03192  540 LLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGN----------------TALWN------ 597

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 189 sieqarALPELHmlEDIRNLLQAGANLDAPRDHGaTLLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYWGQV 268
Cdd:PLN03192  598 ------AISAKH--HKIFRILYHFASISDPHAAG-DLLCTAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHV 668

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 269 RLVELLVAHGADLNGKSLMDE-TPLDVcgdEEVRAKlLELKHK----------HDALLRAQGRQRSllrrRTSSAGSRGK 337
Cdd:PLN03192  669 DMVRLLIMNGADVDKANTDDDfSPTEL---RELLQK-RELGHSitivdsvpadEPDLGRDGGSRPG----RLQGTSSDNQ 740

                         250
                  ....*....|....*..
gi 1387206846 338 VVRRVSLIQRTSLYRRE 354
Cdd:PLN03192  741 CRPRVSIYKGHPLLRNE 757
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 54-275 2.00e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 53.48  E-value: 2.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  54 QKRVLFPPsvtLLEAAARNDLEEVRQFLESGvSPDLANEDGL--TALHQSCIDDFREMVQQLLEAGAR-VN-ARDSECW- 128
Cdd:cd22192    13 QKRISESP---LLLAAKENDVQAIKKLLKCP-SCDLFQRGALgeTALHVAALYDNLEAAVVLMEAAPElVNePMTSDLYq 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 129 --TPLHAAATCGHLRLVELLIARGADLLAVNTDGNM----PYDLCE-DEQTLdcleTAMASRGitqdsieqaralpelhm 201
Cdd:cd22192    89 geTALHIAVVNQNLNLVRELIARGADVVSPRATGTFfrpgPKNLIYyGEHPL----SFAACVG----------------- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 202 LEDI-RNLLQAGANLDAPRDHGATLLHIAAANGFSEAAALLLEHQASLSAKDR----------DGWEPLHAAAYWGQVRL 270
Cdd:cd22192   148 NEEIvRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQMYDLILSYDKEDDlqpldlvpnnQGLTPFKLAAKEGNIVM 227


                  ....*
gi 1387206846 271 VELLV 275
Cdd:cd22192   228 FQHLV 232
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 62-146 1.24e-06

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 51.05  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  62 SVTLLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLR 141
Cdd:PTZ00322   83 TVELCQLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFRE 162


                  ....*
gi 1387206846 142 LVELL 146
Cdd:PTZ00322  163 VVQLL 167
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 72-152 1.80e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 50.43  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  72 NDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLIARGA 151
Cdd:PHA03100  170 NAKNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249


                  .
gi 1387206846 152 D 152
Cdd:PHA03100  250 S 250
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 65-308 1.55e-05

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 47.77  E-value: 1.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  65 LLEAAARNDLEEVRQFLES-GVSPDLanedGLTALHQSCIDDFR--EMVQQLLEAGAR-------VNARDSECW----TP 130
Cdd:TIGR00870  56 LFVAAIENENLELTELLLNlSCRGAV----GDTLLHAISLEYVDavEAILLHLLAAFRksgplelANDQYTSEFtpgiTA 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 131 LHAAATCGHLRLVELLIARGADLlavntdgnmPYDLCEDEqtldCLETAMasrgitQDSIEqaralpelhmledirnllq 210
Cdd:TIGR00870 132 LHLAAHRQNYEIVKLLLERGASV---------PARACGDF----FVKSQG------VDSFY------------------- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 211 aganldaprdHGATLLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAAA----------------------YWGQV 268
Cdd:TIGR00870 174 ----------HGESPLNAAACLGSPSIVALLSEDPADILTADSLGNTLLHLLVmenefkaeyeelscqmynfalsLLDKL 243

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 1387206846 269 R-LVELLVAhgadLNGKslmDETPLDVCGDEEvRAKLLELK 308
Cdd:TIGR00870 244 RdSKELEVI----LNHQ---GLTPLKLAAKEG-RIVLFRLK 276
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 198-301 2.25e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 47.20  E-value: 2.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 198 ELHMLEDIRNLLQAGANLDAPRDHGAT--------LLHIA-------AANGFSEAAALLLEHQASLSAKDRDGWEPLHAA 262
Cdd:PTZ00322   43 EIARIDTHLEALEATENKDATPDHNLTteevidpvVAHMLtvelcqlAASGDAVGARILLTGGADPNCRDYDGRTPLHIA 122

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1387206846 263 AYWGQVRLVELLVAHGADLNGKSLMDETPLDVCGDEEVR 301
Cdd:PTZ00322  123 CANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFR 161
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 197-312 2.60e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 46.58  E-value: 2.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 197 PELHMLEDIRN------LLQAGANLDAPRDHGATLLHIAAANGFS-----EAAALLLEHQASLSAKDRDGWEPLHAAAYW 265
Cdd:PHA03100   37 LPLYLAKEARNidvvkiLLDNGADINSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISK 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387206846 266 --GQVRLVELLVAHGADLNGKSLMDETPLDV-----CGDEEVrAKLLeLKHKHD 312
Cdd:PHA03100  117 ksNSYSIVEYLLDNGANVNIKNSDGENLLHLylesnKIDLKI-LKLL-IDKGVD 168
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 73-282 2.67e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.52  E-value: 2.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  73 DLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNA---RDSEcwTPLHAAATCGHLRLVELLIAR 149
Cdd:PHA02875   47 DSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDvfyKDGM--TPLHLATILKKLDIMKLLIAR 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 150 GADLLAVNTDGNMPydlcedeqtldcLETAMASRGITQdsieqaralpelhmledIRNLLQAGANLDAPRDHGATLLHIA 229
Cdd:PHA02875  125 GADPDIPNTDKFSP------------LHLAVMMGDIKG-----------------IELLIDHKACLDIEDCCGCTPLIIA 175

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387206846 230 AANGFSEAAALLLEHQASLSAKDRDGWEPLHAAAYW-GQVRLVELLVAHGADLN 282
Cdd:PHA02875  176 MAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIEnNKIDIVRLFIKRGADCN 229
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 128-157 2.79e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 2.79e-05
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1387206846 128 WTPLHAAAT-CGHLRLVELLIARGADLLAVN 157
Cdd:pfam00023   3 NTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
Ank_5 pfam13857
Ankyrin repeats (many copies);
208-262 6.16e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 6.16e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387206846 208 LLQAG-ANLDAPRDHGATLLHIAAANGFSEAAALLLEHQASLSAKDRDGWEPLHAA 262
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 254-282 1.14e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 39.11  E-value: 1.14e-04
                           10        20
                   ....*....|....*....|....*....
gi 1387206846  254 DGWEPLHAAAYWGQVRLVELLVAHGADLN 282
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
241-295 1.17e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.02  E-value: 1.17e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387206846 241 LLEH-QASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPLDVC 295
Cdd:pfam13857   1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 201-318 1.44e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 44.62  E-value: 1.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 201 MLEDIRNLL-QAGANLDAPRDHGATLLHIAAANGFSEAAALLLEHQASL-----SAKDRDGWEPLHAAAYWGQVRLVELL 274
Cdd:cd22192    29 DVQAIKKLLkCPSCDLFQRGALGETALHVAALYDNLEAAVVLMEAAPELvnepmTSDLYQGETALHIAVVNQNLNLVREL 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1387206846 275 VAHGAD------------LNGKSLM--DETPLD--VC-GDEEVRAKLLElkhkHDALLRAQ 318
Cdd:cd22192   109 IARGADvvspratgtffrPGPKNLIyyGEHPLSfaACvGNEEIVRLLIE----HGADIRAQ 165
Ank_4 pfam13637
Ankyrin repeats (many copies);
64-114 1.80e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 39.18  E-value: 1.80e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1387206846  64 TLLEAAARNDLEEVRQFLESGVSPDLANEDGLTALHQSCIDDFREMVQQLL 114
Cdd:pfam13637   4 ALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 71-163 1.88e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 43.89  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  71 RNDLEEVRQFLESGVSPDLANEDGLTALHQ--SCIDDFREMVQQLLEAGARVNARDS---------------EC-WTPLH 132
Cdd:PHA03100  118 SNSYSIVEYLLDNGANVNIKNSDGENLLHLylESNKIDLKILKLLIDKGVDINAKNRvnyllsygvpinikdVYgFTPLH 197

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1387206846 133 AAATCGHLRLVELLIARGADLLAVNTDGNMP 163
Cdd:PHA03100  198 YAVYNNNPEFVKYLLDLGANPNLVNKYGDTP 228
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 238-293 1.95e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.28  E-value: 1.95e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1387206846 238 AALLLEHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPLD 293
Cdd:PHA02876  161 AEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLE 216
Ank_4 pfam13637
Ankyrin repeats (many copies);
255-305 2.78e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 2.78e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1387206846 255 GWEPLHAAAYWGQVRLVELLVAHGADLNGKSLMDETPLDVC---GDEEVrAKLL 305
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAasnGNVEV-LKLL 53
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 128-153 3.48e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 37.95  E-value: 3.48e-04
                           10        20
                   ....*....|....*....|....*.
gi 1387206846  128 WTPLHAAATCGHLRLVELLIARGADL 153
Cdd:smart00248   3 RTPLHLAAENGNLEVVKLLLDKGADI 28
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 128-155 3.84e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 37.62  E-value: 3.84e-04
                          10        20
                  ....*....|....*....|....*...
gi 1387206846 128 WTPLHAAATCGHLRLVELLIARGADLLA 155
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADINA 30
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 254-282 6.35e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 37.27  E-value: 6.35e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 1387206846 254 DGWEPLHAAAY-WGQVRLVELLVAHGADLN 282
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVN 30
Ank_4 pfam13637
Ankyrin repeats (many copies);
127-163 7.58e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 7.58e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1387206846 127 CWTPLHAAATCGHLRLVELLIARGADLLAVNTDGNMP 163
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETA 37
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 254-282 9.04e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 36.85  E-value: 9.04e-04
                          10        20
                  ....*....|....*....|....*....
gi 1387206846 254 DGWEPLHAAAYWGQVRLVELLVAHGADLN 282
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
85-134 2.13e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 36.56  E-value: 2.13e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1387206846  85 VSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLHAA 134
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02946 PHA02946
ankyin-like protein; Provisional
 98-292 2.40e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 40.42  E-value: 2.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  98 LHQSC-IDDFRE-MVQQLLEAGARVNARDSECWTPLHAAATCGHLRLVELLIARGADLLAVNTDGNMP--YDLCEDEQTL 173
Cdd:PHA02946   41 LHAYCgIKGLDErFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPlyYLSGTDDEVI 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 174 DCLETAMASRGITQDSIEQARALPELHMLED----IRNLLQAGANLDAPRDHGATLL--HIAAANGFSEAAALLLEHQAS 247
Cdd:PHA02946  121 ERINLLVQYGAKINNSVDEEGCGPLLACTDPservFKKIMSIGFEARIVDKFGKNHIhrHLMSDNPKASTISWMMKLGIS 200

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1387206846 248 LSAKDRDGWEPLH--AAAYWGQVRLVELLVAhGADLNGKSLMDETPL 292
Cdd:PHA02946  201 PSKPDHDGNTPLHivCSKTVKNVDIINLLLP-STDVNKQNKFGDSPL 246
Ank_4 pfam13637
Ankyrin repeats (many copies);
201-242 3.89e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 3.89e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1387206846 201 MLEDIRNLLQAGANLDAPRDHGATLLHIAAANGFSEAAALLL 242
Cdd:pfam13637  13 HLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02946 PHA02946
ankyin-like protein; Provisional
 202-292 4.85e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 39.27  E-value: 4.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846 202 LEDIRNLLQAganlDAPRDHGATLLHIAAANGFSEAAALLLEHQA-SLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGAD 280
Cdd:PHA02946   22 LDVFRNMLQA----IEPSGNYHILHAYCGIKGLDERFVEELLHRGySPNETDDDGNYPLHIASKINNNRIVAMLLTHGAD 97

                          90
                  ....*....|..
gi 1387206846 281 LNGKSLMDETPL 292
Cdd:PHA02946   98 PNACDKQHKTPL 109
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 93-124 5.42e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 34.57  E-value: 5.42e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1387206846  93 DGLTALHQSCID-DFREMVQQLLEAGARVNARD 124
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
PHA02743 PHA02743
Viral ankyrin protein; Provisional
 205-279 5.95e-03

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 37.87  E-value: 5.95e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1387206846 205 IRNLLQAGANLDA-PRDHGATLLHIAAANGFSEAAALLL-EHQASLSAKDRDGWEPLHAAAYWGQVRLVELLVAHGA 279
Cdd:PHA02743   76 IELLVNMGADINArELGTGNTLLHIAASTKNYELAEWLCrQLGVNLGAINYQHETAYHIAYKMRDRRMMEILRANGA 152
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 64-158 6.41e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 39.09  E-value: 6.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  64 TLLEAAARNDLEEVRQFLES-GVSPDLANEDGLTALHQSCIDDFREMVQQLLEAGARVNARDSECWTPLH-AAATCGHLR 141
Cdd:PHA02878  170 TALHYATENKDQRLTELLLSyGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHiSVGYCKDYD 249

                          90
                  ....*....|....*..
gi 1387206846 142 LVELLIARGADLLAVNT 158
Cdd:PHA02878  250 ILKLLLEHGVDVNAKSY 266
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 221-250 7.06e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 7.06e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 1387206846 221 HGATLLHIAAANGFSEAAALLLEHQASLSA 250
Cdd:pfam13606   1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 70-163 7.94e-03

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 39.12  E-value: 7.94e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1387206846  70 ARN-DLEEVRQFLESGVSPDLANEDGLTALHQSCIDDF--REMVQQLLEAGARVNARDSECWTPLHA------------A 134
Cdd:PHA02716  292 ARNiDISVVYSFLQPGVKLHYKDSAGRTCLHQYILRHNisTDIIKLLHEYGNDLNEPDNIGNTVLHTylsmlsvvnildP 371

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1387206846 135 ATCGHLRL--VELLIARGADLLAVNTDGNMP 163
Cdd:PHA02716  372 ETDNDIRLdvIQCLISLGADITAVNCLGYTP 402
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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