NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1390087305|ref|XP_025004062|]
View 

WD repeat-containing protein 86 isoform X2 [Gallus gallus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-298 1.23e-66

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.39  E-value: 1.23e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305   3 NGGSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYItfchleNEAAF--------TCS 74
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV------TSVAFspdgkllaSGS 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  75 ADHTIRKWDVVTGQCLAIYRGHTSIVNRILVAKD--YLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAhysskdvl 152
Cdd:COG2319   182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA-------- 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 153 eeeeeeeeeeerVSRD--LLVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWNIVTGE 230
Cdd:COG2319   254 ------------FSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1390087305 231 QLKVFKEHQGSIICLEL--VNRHLYSGSADRTVKCWLVDTGERIQTYKAHKHSVSTLKYHA--GILFTGSGD 298
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-298 1.23e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.39  E-value: 1.23e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305   3 NGGSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYItfchleNEAAF--------TCS 74
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV------TSVAFspdgkllaSGS 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  75 ADHTIRKWDVVTGQCLAIYRGHTSIVNRILVAKD--YLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAhysskdvl 152
Cdd:COG2319   182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA-------- 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 153 eeeeeeeeeeerVSRD--LLVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWNIVTGE 230
Cdd:COG2319   254 ------------FSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1390087305 231 QLKVFKEHQGSIICLEL--VNRHLYSGSADRTVKCWLVDTGERIQTYKAHKHSVSTLKYHA--GILFTGSGD 298
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-302 1.16e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.94  E-value: 1.16e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  14 HQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYITFCHL--ENEAAFTCSADHTIRKWDVVTGQCLA 91
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  92 IYRGHTSIVN--RILVAKDYLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAhYSSkdvleeeeeeeeeeervSRDL 169
Cdd:cd00200    88 TLTGHTSYVSsvAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA-FSP-----------------DGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 170 LVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWNIVTGEQLKVFKEHQGSIICL--EL 247
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVafSP 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1390087305 248 VNRHLYSGSADRTVKCWLVDTGERIQTYKAHKHSVSTLKYH--AGILFTGSGDACAR 302
Cdd:cd00200   230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpdGKRLASGSADGTIR 286
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 4.14e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1390087305    5 GSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 2.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1390087305   5 GSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 193-309 8.76e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.11  E-value: 8.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 193 LLGHTGAVLCLILDA-PNRELFSGSTDYTIRTWNI----VTGEQLKVFKEHQGSIICLELVNRH------LYSGSADRTV 261
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegLTQNISDPIVHLQGHTKKVGIVSFHpsamnvLASAGADMVV 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1390087305 262 KCWLVDTGERIQTYKAHKHSVSTLKYH-AGILF-TGSGDACARAFNSRSG 309
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNlDGSLLcTTSKDKKLNIIDPRDG 200
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
3-298 1.23e-66

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 214.39  E-value: 1.23e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305   3 NGGSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYItfchleNEAAF--------TCS 74
Cdd:COG2319   108 ATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAV------TSVAFspdgkllaSGS 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  75 ADHTIRKWDVVTGQCLAIYRGHTSIVNRILVAKD--YLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAhysskdvl 152
Cdd:COG2319   182 DDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVA-------- 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 153 eeeeeeeeeeerVSRD--LLVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWNIVTGE 230
Cdd:COG2319   254 ------------FSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGK 321

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1390087305 231 QLKVFKEHQGSIICLEL--VNRHLYSGSADRTVKCWLVDTGERIQTYKAHKHSVSTLKYHA--GILFTGSGD 298
Cdd:COG2319   322 LLRTLTGHTGAVRSVAFspDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPdgRTLASGSAD 393
WD40 COG2319
WD40 repeat [General function prediction only];
4-325 2.17e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 206.30  E-value: 2.17e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305   4 GGSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYItfchleNEAAF--------TCSA 75
Cdd:COG2319    67 AGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAV------RSVAFspdgktlaSGSA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  76 DHTIRKWDVVTGQCLAIYRGHTSIVNRILVAKD--YLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAhysskdvle 153
Cdd:COG2319   141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA--------- 211

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 154 eeeeeeeeeerVSRD--LLVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWNIVTGEQ 231
Cdd:COG2319   212 -----------FSPDgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 232 LKVFKEHQGSIICLELV--NRHLYSGSADRTVKCWLVDTGERIQTYKAHKHSVSTLKYHA--GILFTGSGDACARAFNSR 307
Cdd:COG2319   281 LRTLTGHSGGVNSVAFSpdGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdgKTLASGSDDGTVRLWDLA 360

                         330
                  ....*....|....*...
gi 1390087305 308 SGVLQKIFRGHKFIINCI 325
Cdd:COG2319   361 TGELLRTLTGHTGAVTSV 378
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-302 1.16e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 197.94  E-value: 1.16e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  14 HQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYITFCHL--ENEAAFTCSADHTIRKWDVVTGQCLA 91
Cdd:cd00200     8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  92 IYRGHTSIVN--RILVAKDYLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAhYSSkdvleeeeeeeeeeervSRDL 169
Cdd:cd00200    88 TLTGHTSYVSsvAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA-FSP-----------------DGTF 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 170 LVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWNIVTGEQLKVFKEHQGSIICL--EL 247
Cdd:cd00200   150 VASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVafSP 229

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1390087305 248 VNRHLYSGSADRTVKCWLVDTGERIQTYKAHKHSVSTLKYH--AGILFTGSGDACAR 302
Cdd:cd00200   230 DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSpdGKRLASGSADGTIR 286
WD40 COG2319
WD40 repeat [General function prediction only];
12-325 2.90e-55

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 185.11  E-value: 2.90e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  12 ADHQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYITFCHL--ENEAAFTCSADHTIRKWDVVTGQC 89
Cdd:COG2319    33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFspDGRLLASASADGTVRLWDLATGLL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  90 LAIYRGHTSIVNRILVAKD--YLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAhysskdvleeeeeeeeeeerVSR 167
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDgkTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVA--------------------FSP 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 168 D--LLVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWNIVTGEQLKVFKEHQGSIICL 245
Cdd:COG2319   173 DgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 246 ELV--NRHLYSGSADRTVKCWLVDTGERIQTYKAHKHSVSTLKYHAG--ILFTGSGDACARAFNSRSGVLQKIFRGHKFI 321
Cdd:COG2319   253 AFSpdGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332


                  ....
gi 1390087305 322 INCI 325
Cdd:COG2319   333 VRSV 336
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-264 7.03e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 172.90  E-value: 7.03e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  14 HQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYITFCHL--ENEAAFTCSADHTIRKWDVVTGQCLA 91
Cdd:cd00200    50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFspDGRILSSSSRDKTIKVWDVETGKCLT 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  92 IYRGHTSIVNRILVAKD--YLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAhySSKDvleeeeeeeeeeervsRDL 169
Cdd:cd00200   130 TLRGHTDWVNSVAFSPDgtFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVA--FSPD----------------GEK 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 170 LVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWNIVTGEQLKVFKEHQGSIICLELVN 249
Cdd:cd00200   192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271

                         250
                  ....*....|....*..
gi 1390087305 250 --RHLYSGSADRTVKCW 264
Cdd:cd00200   272 dgKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 49-327 1.50e-51

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 172.13  E-value: 1.50e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  49 CHGHFQGHESYITFCHL--ENEAAFTCSADHTIRKWDVVTGQCLAIYRGHTSIVNRILV--AKDYLFSGSYDRTARCWSV 124
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFspDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAsaDGTYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 125 DKEKQIQEFRGHRNCVLTLAhYSSkdvleeeeeeeeeeervSRDLLVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLI 204
Cdd:cd00200    81 ETGECVRTLTGHTSYVSSVA-FSP-----------------DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 205 LDAPNRELFSGSTDYTIRTWNIVTGEQLKVFKEHQGSI--ICLELVNRHLYSGSADRTVKCWLVDTGERIQTYKAHKHSV 282
Cdd:cd00200   143 FSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVnsVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGV 222

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1390087305 283 STLKYHAG--ILFTGSGDACARAFNSRSGVLQKIFRGHKFIINCIQV 327
Cdd:cd00200   223 NSVAFSPDgyLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
22-325 3.66e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 3.66e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  22 SLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYIT--FCHLENEAAFTCSADHTIRKWDVVTGQCLAIYRGHTSI 99
Cdd:COG2319     1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVAslAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 100 VNRILVAKD--YLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAhysskdvleeeeeeeeeeerVSRD--LLVTGST 175
Cdd:COG2319    81 VLSVAFSPDgrLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVA--------------------FSPDgkTLASGSA 140

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 176 DCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWNIVTGEQLKVFKEHQGSIICLELV--NRHLY 253
Cdd:COG2319   141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKLLA 220

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1390087305 254 SGSADRTVKCWLVDTGERIQTYKAHKHSVSTLKYHAG--ILFTGSGDACARAFNSRSGVLQKIFRGHKFIINCI 325
Cdd:COG2319   221 SGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSV 294
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 14-225 7.17e-41

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 144.01  E-value: 7.17e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  14 HQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYITFC--HLENEAAFTCSADHTIRKWDVVTGQCLA 91
Cdd:cd00200    92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVafSPDGTFVASSSQDGTIKLWDLRTGKCVA 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  92 IYRGHTSIVNRILVAKDY--LFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAHYSSkdvleeeeeeeeeeervsRDL 169
Cdd:cd00200   172 TLTGHTGEVNSVAFSPDGekLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD------------------GYL 233

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1390087305 170 LVTGSTDCTVKVWWVSSGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWN 225
Cdd:cd00200   234 LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 5-182 1.69e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 116.67  E-value: 1.69e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305   5 GSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYITFC--HLENEAAFTCSADHTIRKW 82
Cdd:cd00200   125 GKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVafSPDGEKLLSSSSDGTIKLW 204

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305  83 DVVTGQCLAIYRGHTSIVNRILVAKD--YLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLAHYSSKDVleeeeeeee 160
Cdd:cd00200   205 DLSTGKCLGTLRGHENGVNSVAFSPDgyLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKR--------- 275

                         170       180
                  ....*....|....*....|..
gi 1390087305 161 eeervsrdlLVTGSTDCTVKVW 182
Cdd:cd00200   276 ---------LASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 2-123 9.71e-25

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 101.26  E-value: 9.71e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305   2 GNGGSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWSTADSQCHGHFQGHESYITFC--HLENEAAFTCSADHTI 79
Cdd:cd00200   164 LRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVafSPDGYLLASGSEDGTI 243

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1390087305  80 RKWDVVTGQCLAIYRGHTSIVNRILVAKD--YLFSGSYDRTARCWS 123
Cdd:cd00200   244 RVWDLRTGECVQTLSGHTNSVTSLAWSPDgkRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
3-46 5.37e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.76  E-value: 5.37e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1390087305   3 NGGSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWSTAD 46
Cdd:COG2319   360 ATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 5-43 4.14e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.14e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1390087305    5 GSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
5-43 2.04e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.04e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1390087305   5 GSAVKVCADHQGGINWLSLSPDGQRLLTGSEDGTARLWS 43
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 193-309 8.76e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.11  E-value: 8.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 193 LLGHTGAVLCLILDA-PNRELFSGSTDYTIRTWNI----VTGEQLKVFKEHQGSIICLELVNRH------LYSGSADRTV 261
Cdd:PTZ00421   71 LLGQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIpeegLTQNISDPIVHLQGHTKKVGIVSFHpsamnvLASAGADMVV 150

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1390087305 262 KCWLVDTGERIQTYKAHKHSVSTLKYH-AGILF-TGSGDACARAFNSRSG 309
Cdd:PTZ00421  151 NVWDVERGKAVEVIKCHSDQITSLEWNlDGSLLcTTSKDKKLNIIDPRDG 200
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 107-264 2.18e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 2.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 107 KDYLFSGSYDRTARCWSVDKEKQIQEFRGHRNCVLTLaHYSSKDvleeeeeeeeeeervsRDLLVTGSTDCTVKVWWVSS 186
Cdd:PLN00181  545 KSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSI-DYSSAD----------------PTLLASGSDDGSVKLWSINQ 607

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1390087305 187 GRCYQTLlgHTGAVLCLIL--DAPNRELFSGSTDYTIRTWNIVTGE-QLKVFKEHQGSIICLELVNRH-LYSGSADRTVK 262
Cdd:PLN00181  608 GVSIGTI--KTKANICCVQfpSESGRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSStLVSSSTDNTLK 685


                  ..
gi 1390087305 263 CW 264
Cdd:PLN00181  686 LW 687
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 186-225 3.15e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.15e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1390087305  186 SGRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWN 225
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 86-123 4.32e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 4.32e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1390087305   86 TGQCLAIYRGHTSIVNRILVAKD--YLFSGSYDRTARCWS 123
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDgkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
187-225 7.99e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 7.99e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1390087305 187 GRCYQTLLGHTGAVLCLILDAPNRELFSGSTDYTIRTWN 225
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
87-123 1.35e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1390087305  87 GQCLAIYRGHTSIVNRILVAKD--YLFSGSYDRTARCWS 123
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDgkLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 228-264 1.93e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 1.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1390087305  228 TGEQLKVFKEHQGSIICLELV--NRHLYSGSADRTVKCW 264
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSpdGKYLASGSDDGTIKLW 39
Nup160 pfam11715
Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous ...
 70-92 6.48e-03

Nucleoporin Nup120/160; Nup120 is conserved from fungi to plants to humans, and is homologous with the Nup160 of vertebrates. The nuclear core complex, or NPC, mediates macromolecular transport across the nuclear envelope. Deletion of the NUP120 gene causes clustering of NPCs at one side of the nuclear envelope, moderate nucleolar fragmentation and slower cell growth. The vertebrate NPC is estimated to contain between 30 and 60 different proteins. most of which are not known. Two important ones in creating the nucleoporin basket are Nup98 and Nup153, and Nup120, in conjunction with Nup 133, interacts with these two and itself plays a role in mRNA export. Nup160, Nup133, Nup96, and Nup107 are all targets of phosphorylation. The phosphorylation sites are clustered mainly at the N-terminal regions of these proteins, which are predicted to be natively disordered. The entire Nup107-160 sub-complex is stable throughout the cell cycle, thus it seems unlikely that phosphorylation affects interactions within the Nup107-160 sub-complex, but rather that it regulates the association of the sub-complex with the NPC and other proteins.


Pssm-ID: 432020 [Multi-domain]  Cd Length: 540  Bit Score: 38.21  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|...
gi 1390087305  70 AFTCSADHTIRKWDVVTGQCLAI 92
Cdd:pfam11715 237 LFTLSLDHTLRVWDLLTGKCLAT 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH