Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
627-867
2.93e-31
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.
The actual alignment was detected with superfamily member smart00222:
Pssm-ID: 469626 [Multi-domain] Cd Length: 189 Bit Score: 122.40 E-value: 2.93e-31
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
1343-1400
4.84e-09
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.
The actual alignment was detected with superfamily member pfam09324:
Pssm-ID: 462756 Cd Length: 84 Bit Score: 55.19 E-value: 4.84e-09
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
5-143
3.44e-08
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.
The actual alignment was detected with superfamily member pfam16213:
Pssm-ID: 465072 [Multi-domain] Cd Length: 172 Bit Score: 55.34 E-value: 3.44e-08
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
2217-2269
3.07e-03
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.
The actual alignment was detected with superfamily member pfam20252:
Pssm-ID: 466403 Cd Length: 178 Bit Score: 40.69 E-value: 3.07e-03
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
1859-1947
7.29e-03
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.
The actual alignment was detected with superfamily member pfam20252:
Pssm-ID: 466403 Cd Length: 178 Bit Score: 39.92 E-value: 7.29e-03
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
627-867
2.93e-31
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).
Pssm-ID: 214569 [Multi-domain] Cd Length: 189 Bit Score: 122.40 E-value: 2.93e-31
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
633-867
1.33e-23
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.
Pssm-ID: 238100 Cd Length: 185 Bit Score: 99.99 E-value: 1.33e-23
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
1343-1400
4.84e-09
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.
Pssm-ID: 462756 Cd Length: 84 Bit Score: 55.19 E-value: 4.84e-09
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
5-143
3.44e-08
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.
Pssm-ID: 465072 [Multi-domain] Cd Length: 172 Bit Score: 55.34 E-value: 3.44e-08
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
2217-2269
3.07e-03
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.
Pssm-ID: 466403 Cd Length: 178 Bit Score: 40.69 E-value: 3.07e-03
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
1859-1947
7.29e-03
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.
Pssm-ID: 466403 Cd Length: 178 Bit Score: 39.92 E-value: 7.29e-03
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for ...
627-867
2.93e-31
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product, which is required for proper protein transport through the Golgi. The domain facilitates guanine nucleotide exchange on the small GTPases, ARFs (ADP ribosylation factors).
Pssm-ID: 214569 [Multi-domain] Cd Length: 189 Bit Score: 122.40 E-value: 2.93e-31
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the ...
633-867
1.33e-23
Sec7 domain; Domain named after the S. cerevisiae SEC7 gene product. The Sec7 domain is the central domain of the guanine-nucleotide-exchange factors (GEFs) of the ADP-ribosylation factor family of small GTPases (ARFs) . It carries the exchange factor activity.
Pssm-ID: 238100 Cd Length: 185 Bit Score: 99.99 E-value: 1.33e-23
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized ...
1343-1400
4.84e-09
Domain of unknown function (DUF1981); Members of this family of functionally uncharacterized domains are found in various plant and yeast protein transport proteins.
Pssm-ID: 462756 Cd Length: 84 Bit Score: 55.19 E-value: 4.84e-09
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and ...
5-143
3.44e-08
dimerization and cyclophilin-binding domain of Mon2; DCB is the N-terminal domain of Mon2- and GIG1-like proteins from metazoa. Mon2 and BIG1 like proteins play an important role in the cytoplasm-to-vacuole transport pathway and are required for Golgi homeostasis.
Pssm-ID: 465072 [Multi-domain] Cd Length: 172 Bit Score: 55.34 E-value: 3.44e-08
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
2217-2269
3.07e-03
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.
Pssm-ID: 466403 Cd Length: 178 Bit Score: 40.69 E-value: 3.07e-03
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin ...
1859-1947
7.29e-03
BIG2 C-terminal domain; This presumed domain is found at the C-terminus of BIG2 the brefeldin A-inhibited guanine nucleotide-exchange protein. The function of this region is unknown.
Pssm-ID: 466403 Cd Length: 178 Bit Score: 39.92 E-value: 7.29e-03
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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of your query sequence and the protein sequences used to curate the domain model,
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The thumbnail image, if present, provides an approximate view of the feature's location in 3 dimensions.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
The Show Concise/Full Display button at the top of the page can be used to select the desired level of detail: only top scoring hits
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Domains are color coded according to superfamilies
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if a domain or superfamily has been annotated with functional sites (conserved features),
they are mapped to the query sequence and indicated through sets of triangles
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click on the bars or triangles to view your query sequence embedded in a multiple sequence alignment of the proteins used to develop the corresponding domain model.
The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
Click on the domain model's accession number to view the multiple sequence alignment of the proteins used to develop the corresponding domain model.
To view your query sequence embedded in that multiple sequence alignment, click on the colored bars in the Graphical Summary portion of the search results page,
or click on the triangles, if present, that represent functional sites (conserved features)
mapped to the query sequence.
Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
(labeled illustration) Full Display shows all domain models, in each hit category below, that meet or exceed the RPS-BLAST threshold for statistical significance.
(labeled illustration) Four types of hits can be shown, as available,
for each region on the query sequence:
specific hits meet or exceed a domain-specific e-value threshold
(illustrated example)
and represent a very high confidence that the query sequence belongs to the same protein family as the sequences use to create the domain model
non-specific hits
meet or exceed the RPS-BLAST threshold for statistical significance (default E-value cutoff of 0.01, or an E-value selected by user via the
advanced search options)
the domain superfamily to which the specific and non-specific hits belong
multi-domain models that were computationally detected and are likely to contain multiple single domains
Retrieve proteins that contain one or more of the domains present in the query sequence, using the Conserved Domain Architecture Retrieval Tool
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