BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 375 PDDHLTVAQSLKKEFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDEIIEMSEFPYPVYRAFLEYLYTDNI 454
Cdd:cd18354     1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1394746101 455 SLPPEDAIGLLDLATLYRENRLKKLCQQTIKQGICEE 491
Cdd:cd18354    81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1394746101 488 ICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTQGFAEMDHDLLKNFISKASRVGAFKN 552
Cdd:cd18529     1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 375 PDDHLTVAQSLKKEFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDEIIEMSEFPYPVYRAFLEYLYTDNI 454
Cdd:cd18354     1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1394746101 455 SLPPEDAIGLLDLATLYRENRLKKLCQQTIKQGICEE 491
Cdd:cd18354    81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1394746101 488 ICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTQGFAEMDHDLLKNFISKASRVGAFKN 552
Cdd:cd18529     1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 385 LKKEFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDE----IIEMSEFPYPVYRAFLEYLYTDNIsLPPED 460
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESEssvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 1394746101 461 AIGLLDLATLYRENRLKKLCQQTIKQ 486
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105

kelch-like protein; Provisional

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 399 FLVDGKYIHVHKVLLKIRCEHFRSILSNN--DDEIieMSEFPYPVYRAFLEYLYTDNISLPPEDAIGLLDLATLYRENRL 476
Cdd:PHA03098   16 IVNGGGIIKVHKIILSSSSEYFKKMFKNNfkENEI--NLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFL 93

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1394746101 477 KKLCQQTIKQGICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVtqtqgfaEMDHDLLK 538
Cdd:PHA03098   94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI-------YNDPDFIY 148

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 375 PDDHLTVAQSLKKEFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDEIIEMSEFPYPVYRAFLEYLYTDNI 454
Cdd:cd18354     1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1394746101 455 SLPPEDAIGLLDLATLYRENRLKKLCQQTIKQGICEE 491
Cdd:cd18354    81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101  54 SAGNE-VLYTTENNEVFGLGTNSSGCLGTGDIQSTIEPRRLDALCG-KRIAClsyGSGpHVVLATAEGEVYSWGHNAYSQ 131
Cdd:COG5184     4 AAGGShSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSNvVAVAA---GGD-HTCALKADGTVWCWGNNSYGQ 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 132 LGNGTTNHGLVPCQVStNLVNkkVIEVTCGSHHSMVLTSDGEVYTWGYNNSGQVGSGSTANQPIPRRVTSGIQNkiIVNI 211
Cdd:COG5184    80 LGDGTTTDRTTPVKVP-GLTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG--VVAI 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 212 ACGQMCSMAVVQNGEVYAWGYNGNGQLGLGNTGNQPTPCRIAALQGirVQQVACGYAHTLVLTDEGRIYAWGANSYGQLG 291
Cdd:COG5184   155 AAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLG 232

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 1394746101 292 IGNKNNQSYPAPViVDKDRVVEIAAchSAHTSAAKTQSGQVYMWGQ 337
Cdd:COG5184   233 DGTTTDRATPVQV-AGLTGVVAIAA--GGSHTCALKSDGTVWCWGD 275

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 383 QSLKKEFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNN----DDEIIEMSEFPYPVYRAFLEYLYTDNISLPP 458
Cdd:cd18298     1 DSLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHwnedDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPP 80

                          90       100
                  ....*....|....*....|....*...
gi 1394746101 459 EDAIGLLDLATLYRENRLKKLCQQTIKQ 486
Cdd:cd18298    81 EDAIGLLDLANSYCEERLKKLCEDIIKQ 108

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1394746101 488 ICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTQGFAEMDHDLLKNFISKASRVGAFKN 552
Cdd:cd18529     1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1, also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), or CLL deletion region gene 7 protein, or regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5, is a novel chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. Moreover, RCBTB1 acts as a putative substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1394746101 487 GICEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTQGFAEMDHDLLKNFISKASRVGAFKN 552
Cdd:cd18528     1 GITVENAFSLLSAAVRYDAEDLEEFCFKFCVNHLTEVTQTAAFWQMDGNLLKEFIAKASKCGAFKN 66

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101  396 DLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDE----IIEMSEFPYPVYRAFLEYLYTDNISLPPEDAIGLLDLATLY 471
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKEsdksEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 1394746101  472 RENRLKKLCQQTIKQGI 488
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 385 LKKEFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDE----IIEMSEFPYPVYRAFLEYLYTDNIsLPPED 460
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESEssvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 1394746101 461 AIGLLDLATLYRENRLKKLCQQTIKQ 486
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 395 ADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDE----IIEMSEFPYPVYRAFLEYLYTDNISLPPEDAIGLLDLATL 470
Cdd:cd18186     2 CDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMKEssssEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADK 81

                  .
gi 1394746101 471 Y 471
Cdd:cd18186    82 L 82

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 389 FDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDE----IIEMSEFPYPVYRAFLEYLYTDNISLPPE-DAIG 463
Cdd:cd18300     4 LNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNFREssakEVELPGVSKETFLALLEYLYTDQAPILEDgDCVG 83

                          90       100
                  ....*....|....*....|.
gi 1394746101 464 LLDLATLYRENRLKKLCQQTI 484
Cdd:cd18300    84 LIVLANRLCLPRLVALCEQYI 104

Regulator of chromosome condensation (RCC1) repeat;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1394746101 118 EGEVYSWGHNAYSQLGNGTTNHGLVPCQVSTnLVNKKVIEVTCGSHHSMVL 168
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEG-LSGNKVVQVACGGDHTVAL 50

Regulator of chromosome condensation (RCC1) repeat;

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1394746101 171 DGEVYTWGYNNSGQVGSGSTANQPIPRRVTSGIQNKIIVnIACGQMCSMAV 221
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQ-VACGGDHTVAL 50

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 390 DNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDE---------IIEMSEFPYPVYRAFLEYLYTDNISLPPED 460
Cdd:cd18296    13 QELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHFAEseenngsipVVTLHDVSPEVFAIVLYYIYTDDTDLPPEN 92

                          90       100
                  ....*....|....*....|....*....
gi 1394746101 461 AIGLLDLATLYRENRLKKLCQQTIKQGIC 489
Cdd:cd18296    93 AYDVLYVADMYLLPGLKRLCGTVLAQSLD 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 377 DHLT-VAQSLKKEFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSIL------SNNDDeiIEMSEFPYPVYRAFLEYL 449
Cdd:cd18287     4 DHVHfLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmreSQQSE--IELKDTNAEAFKALLKYI 81

                          90       100
                  ....*....|....*....|....*
gi 1394746101 450 YTDNISL--PPEDAI-GLLDLATLY 471
Cdd:cd18287    82 YTGRLTLtdLKEDVLlDVLGLAHQY 106

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1394746101 489 CEENAIALLSAAVKYEAQDLEEFCFRFCINHLTVVTQTQGFAEMDHDLLKNFIS 542
Cdd:cd14733     1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLS 54

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 379 LTVAQSLkkeFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDEiIEMSEFPYPVYRAFLEYLYTDNISLpP 458
Cdd:cd18303     6 LKTVASL---FDKELYSDITIKLADKSIPAHKFVLAARSEKWSNENLASTNE-LDLSDISYEVVLALLRWLYTDELDL-T 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1394746101 459 EDAIGLLDLATLYRENRLKKLcqqtikQGICEENAIALL 497
Cdd:cd18303    81 LDDEFLLELMKAAKRFQLTDL------VERCERALMSSV 113

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 392 PETADLKFLVDGKYIHVHKVLLKIRCEH----FRSILSNNDDEIIEMSEFpYPVYRAF---LEYLYTDNISLPPEDAIGL 464
Cdd:cd18309    18 GDFCDITLLLDGHPIPAHKAILAARCSYfeamFRSFMPEDNTVNISIGEM-VPSRQAFdslLRYIYYGDVTMPPEDSLYL 96

                          90       100       110
                  ....*....|....*....|....*....|
gi 1394746101 465 LDLATLY--RENRLKKLCQQTIKQGICEEN 492
Cdd:cd18309    97 FSAPYFYgfTNNRLQAYCKQNLEMNVSFEN 126

Regulator of chromosome condensation (RCC1) repeat;

                          10        20        30
                  ....*....|....*....|....*....|
gi 1394746101 155 VIEVTCGSHHSMVLTSDGEVYTWGYNNSGQ 184
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 385 LKKEFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNddeIIEMSEFPYPVY-------RAFLEYLYTDniSLP 457
Cdd:cd18360     1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEVMAAMFNGN---YAEAKSFLVPIYgvskdtfLSFLEYLYTD--SCC 75

                          90       100       110
                  ....*....|....*....|....*....|
gi 1394746101 458 PE---DAIGLLDLATLYRENRLKKLCQQTI 484
Cdd:cd18360    76 PAsilQAMALLICAEMYQVSRLQHICELYI 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 383 QSLKKEFDNPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDEI------IEMSEFPYPVYRAFLEYLYTDNISL 456
Cdd:cd18245     3 RALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDdgstykIELEGISVEVMEEILDYIYTGQIKL 82

                          90       100
                  ....*....|....*....|....
gi 1394746101 457 PPEDAIGLLDLATLYRENRLKKLC 480
Cdd:cd18245    83 SEDNIQDIVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1394746101 398 KFLVDGKYIHVHKVLLKIRCEHFRSILS-----NNDDEIIeMSEFPYPVYRAFLEYLYTDNISLPPEDAIGLLDLATLY 471
Cdd:cd01165     2 VLVVEGEKFHVNKELLAQSSEYFRALFRggfreSGQAEIN-LRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 375 PDDHLTVAQSLKKEfdnPETADLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDDEI----IEMSEFPYPVYRAFLEYLY 450
Cdd:cd18237     5 LADFMGVMNNMRKQ---KTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESksseVELKDAEPDIIELLVEFAY 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1394746101 451 TDNISLPPEDAIGLLDLATLYRENRLKKLCQQTIKQGICEEN 492
Cdd:cd18237    82 TARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLKEQLDASN 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1394746101 396 DLKFLVDGKYIHVHKVLLKIRCEHFRSILSNNDD-EIIEMSEFPYPVYRAFLEYLYT 451
Cdd:cd18226    24 DLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPNtDAVTLDHVSYSVFQHLLEFLYT 80

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 385 LKKEFDNPETADLKFLVDGKY-IHVHKVLLKIRCEHFRSILSNNddEIIEMSEFPYP-VYRAFLEYLYTDNISLPPEDAI 462
Cdd:cd18299     3 LRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFLMM--TVVTLDSDITPeAFRRVLEFLYTGVLDENEDDLK 80

                  ....*.
gi 1394746101 463 GLLDLA 468
Cdd:cd18299    81 ELKDAA 86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394746101 380 TVAQSLKKEFDNPETADLKFLVDGKYIHVHKVLLKiRCEHFRSILSNN----DDEIIEMsEFPYP------VYRAFLEyL 449
Cdd:cd18305     1 TSKYIYQTLFLNGENSDITICALGREWKLHKIYLC-QSGYFASMFSGSwkesKETVINL-EIPDDnitveaLNVVFGS-L 77